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https://www.readbyqxmd.com/read/29458107/wnt-receptor-signalling-in-lung-physiology-and-pathology
#1
REVIEW
Wioletta Skronska-Wasek, Reinoud Gosens, Melanie Königshoff, Hoeke Abele Baarsma
The WNT signalling cascades have emerged as critical regulators of a wide variety of biological aspects involved in lung development as well as in physiological and pathophysiological processes in the adult lung. WNTs (secreted glycoproteins) interact with various transmembrane receptors and co-receptors to activate signalling pathways that regulate transcriptional as well as non-transcriptional responses within cells. In physiological conditions, the majority of WNT receptors and co-receptors can be detected in the adult lung...
February 16, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29455115/therapeutic-use-of-heparin-and-derivatives-beyond-anticoagulation-in-patients-with-bronchial-asthma-or-copd
#2
REVIEW
Janis K Shute, Ermanno Puxeddu, Luigino Calzetta
In this review, we identify potential targets for the therapeutic effects of heparin in asthma and chronic obstructive pulmonary disease (COPD), consider the safety and delivery modalities of this therapeutic approach. Specifically, we point to the anti-inflammatory, antioxidant and mucolytic effects of unfractionated heparin with potential to modify disease progression in COPD and asthma when administered via the inhaled route. Inhaled heparin may represent an effective add-on therapy in COPD and asthma patient groups, especially when taking into consideration the relative deficiency in endogenous heparin reported in asthma patients...
February 15, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29446981/diet-pattern-and-respiratory-morbidity-in-the-atherosclerosis-risk-in-communities-study
#3
Emily P Brigham, Lyn M Steffen, Stephanie J London, Danielle Boyce, Gregory B Diette, Nadia N Hansel, Jessica Rice, Meredith C McCormack
RATIONALE: Dietary intake is a potential risk factor for respiratory morbidity in adult populations. Few studies capture the effect of diet patterns, representative of combination of nutrients consumed, on respiratory morbidity in combination with objective measures of lung function. OBJECTIVES: To evaluate patterns of dietary intake in relation to respiratory morbidity and objective measures of lung function in a U.S. POPULATION: <AbstractText Label="METHODS" NlmCategory="METHODS">The Atherosclerosis Risk in Communities (ARIC) Study enrolled 15,792 participants from four U...
February 15, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29437221/the-complexity-of-determining-whether-a-nursing-home-transfer-is-avoidable-at-time-of-transfer
#4
Kathleen T Unroe, Jennifer L Carnahan, Susan E Hickman, Greg A Sachs, Zachary Hass, Greg Arling
OBJECTIVES: To describe the relationship between nursing facility resident risk conditions and signs and symptoms at time of acute transfer and diagnosis of conditions associated with potentially avoidable acute transfers (pneumonia, urinary tract infection, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) or asthma, dehydration, pressure sores). DESIGN: As part of a demonstration project to reduce potentially avoidable hospital transfers, Optimizing Patient Transfers, Impacting Medical Quality, Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project clinical staff collected data on residents who transferred to the emergency department (ED) or hospital...
February 13, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29437007/blood-eosinophils-as-biomarkers-to-drive-treatment-choices-in-asthma-and-copd
#5
Francesco Patalano, Konstantinos Kostikas, Caterina Brindicci
Both asthma and COPD are complex, heterogeneous conditions comprising a wide range of phenotypes, some of which are refractory to currently available treatments. Elucidation of these phenotypes and identification of biomarkers with which to recognize them and guide appropriate treatment remains a priority. This review describes the utility of blood eosinophils as a surrogate biomarker of eosinophilic airway inflammation, a common feature of specific asthma and COPD phenotypes. The role of blood eosinophils in airway disease is described, as is their relevance in reflecting airway eosinophilia...
February 12, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29433946/definition-and-diagnosis-of-asthma-copd-overlap-aco
#6
REVIEW
Satoru Yanagisawa, Masakazu Ichinose
It is now widely recognized that asthma and COPD can coexist as asthma-COPD overlap (ACO), but the preliminary attempts at providing universal guidelines for the diagnosis of ACO still need to be improved. We believe that a case can be made for devising guidelines for the diagnosis of this increasingly common disease that are specific to Japan. In this paper, we present our consensus-based description of ACO which we believe is realistic for use in our country. In addition, we cite the scientific evidence for our own "objective" features used to develop the criteria for COPD and asthma diagnosis...
February 9, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29432960/use-of-ics-laba-combinations-or-lama-is-associated-with-a-lower-risk-of-acute-exacerbation-in-patients-with-coexistent-copd-and-asthma
#7
Vincent Yi-Fong Su, Kuang-Yao Yang, Yao-Hsu Yang, Ying-Huang Tsai, Diahn-Warng Perng, Wei-Juin Su, Kun-Ta Chou, Kang-Cheng Su, Yung-Feng Yen, Pau-Chung Chen
BACKGROUND: Based on current guidelines, more research is urgently needed to guide appropriate treatment for patients with asthma-chronic obstructive pulmonary disease overlap. OBJECTIVE: The objective of this study was to investigate medication effects on acute exacerbation in patients with coexistent COPD and asthma. METHODS: Using Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study to evaluate medication effects in patients with COPD and asthma...
February 9, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29431543/high-flow-nasal-oxygen-therapy-utilization-7-year-experience-at-a-community-teaching-hospital
#8
Mihaela S Stefan, Patrick Eckert, Bogdan Tiru, Jennifer Friderici, Peter K Lindenauer, Jay S Steingrub
OBJECTIVE: To examine the use of high flow nasal cannula oxygen therapy (HFNC) between 2008 and 2014 in patients 18 years or older at a community teaching hospital. METHODS: Yearly utilization rates of HFNC, noninvasive ventilation (NIV) and invasive mechanical ventilation (IMV) were calculated among admissions with a set of cardiopulmonary diagnoses (heart failure, COPD, asthma or pneumonia). RESULTS: Among the 41,711 admissions with at least one of the above cardiopulmonary condition, HFNC was utilized in 1,128 or 27...
February 15, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29427967/pleiotropic-effects-of-hypoglycemic-agents-implications-in-asthma-and-copd
#9
REVIEW
Paola Rogliani, Josuel Ora, Nicola Di Daniele, Davide Lauro
Diabetes mellitus (DM) is a complex multifactorial disease due to the interaction between environmental noxae and genetic predisposition. Furthermore, an increased association between DM, especially Type 2 diabetes mellitus (T2DM), and the onset of pulmonary function impairment with a bronchial hyperresponsiveness has been documented. DM is a risk factor for accelerated decline in FEV1 and the development of asthma and COPD. The increased blood glucose concentrations along with higher levels of oxidative stress and inflammation can influence the pulmonary function and, since hypoglycemic drugs can act on these different defects we can hypothesize their direct effect on obstructive pulmonary diseases...
February 7, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29420087/prevalence-and-features-of-asthma-chronic-obstructive-pulmonary-disease-overlap-in-northern-italy-general-population
#10
Massimo Guerriero, Marco Caminati, Giovanni Viegi, Gianenrico Senna, Carlo Pomari
OBJECTIVE: There is controversy about the diagnostic criteria, prevalence, symptoms, and spirometry characteristics of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO). Recent data indicate that the fixed method for diagnosing airway obstruction (AO) may overestimate ACO prevalence in the elderly, and a variable method may be more accurate. We aimed at estimating ACO prevalence in a general population sample and comparing patient and clinical features in subjects with ACO, COPD, and asthma...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29413512/the-revised-gold-2017-copd-categorization-in-relation-to-comorbidities
#11
Kathrin Kahnert, Peter Alter, David Young, Tanja Lucke, Joachim Heinrich, Rudolf M Huber, Jürgen Behr, Margarethe Wacker, Frank Biertz, Henrik Watz, Robert Bals, Tobias Welte, Hubert Wirtz, Felix Herth, Jørgen Vestbo, Emiel F Wouters, Claus F Vogelmeier, Rudolf A Jörres
INTRODUCTION: The COPD classification proposed by the Global Initiative for Obstructive Lung Disease was recently revised, and the A to D grouping is now based on symptoms and exacerbations only. Potential associations with comorbidities have not been assessed so far. Thus the aim of the present study was to determine the relationship between the revised (2017) GOLD groups A-D and major comorbidities. METHODS: We used baseline data from the COPD cohort COSYCONET...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29413497/a-retrospective-cohort-study-in-severe-asthma-describing-commonly-measured-biomarkers-eosinophil-count-and-ige-levels
#12
John Haughney, Alyn Morice, Kevin G Blyth, Amanda J Lee, Alasdair Coutts, Eddie McKnight, Ian Pavord
BACKGROUND: Identifying asthma patients suitable for biologic therapy includes the assessment of blood biomarkers (IgE and eosinophils (EOS)). How they relate to each other is unclear. METHODS: This retrospective, database study used routinely collected clinical data to identify and evaluate an asthma cohort (classification code for asthma; ≥ 18 years; ≥1 prescription for asthma; ≥1 estimation of serum IgE, in 2 years prior to index date). Distribution into high and low IgE and EOS groups (IgE cut-point: > or ≤75 kU/L; EOS cut point: >or ≤400 μ/L), and characteristics by group are described...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29412485/advancing-the-management-of-obstructive-airways-diseases-through-translational-research
#13
Celeste Porsbjerg, Asger Sverrild, Katherine J Baines, Andrew Searles, Steven Maltby, Paul S Foster, Chris Brightling, Peter G Gibson
Obstructive airways diseases (OAD) represent a huge burden of illness worldwide, and in spite of the development of effective therapies, significant morbidity and mortality related to asthma and COPD still remains. Over the past decade, our understanding of OAD has improved vastly, and novel treatments have evolved. This evolution is the result of successful translational research, which has connected clinical presentations of OAD and underlying disease mechanisms, thereby enabling the development of targeted treatments...
February 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29411860/self-management-for-bronchiectasis
#14
REVIEW
Carol Kelly, Seamus Grundy, Dave Lynes, David Jw Evans, Sharada Gudur, Stephen J Milan, Sally Spencer
BACKGROUND: Bronchiectasis is a long term respiratory condition with an increasing rate of diagnosis. It is associated with persistent symptoms, repeated infective exacerbations, and reduced quality of life, imposing a burden on individuals and healthcare systems. The main aims of therapeutic management are to reduce exacerbations and improve quality of life. Self-management interventions are potentially important for empowering people with bronchiectasis to manage their condition more effectively and to seek care in a timely manner...
February 7, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29405628/death-specific-rate-due-to-asthma-and-chronic-obstructive-pulmonary-disease-in-iran
#15
Mehdi Varmaghani, Abbas Kebriaeezadeh, Farshad Sharifi, Ali Sheidaei, Arash Rashidian, Maziar Moradi-Lakeh, Roozbeh Naghshin, Mostafa Moin, Parinaz Mehdipour, Elham Heidari, Kimiya Gohari, Nazila Rezaei, Rosa Haghshenas, Farzad Kompani, Farshad Farzadfar
BACKGROUND: Asthma and COPD could be considered as a major health problem in industrialized and developing countries. The present study was designed to analyze the trends of mortality from asthma and COPD at national and sub-national levels in Iran based on national death registry, from 2001 to 2015. METHODS: We used Death Registration System (DRS) as the basic source of data. DRS data were available from 1995 to 2010 in Iran's Ministry of Health. Although, Tehran and Isfahan, two most populated cities in Iran, had independent death registry systems in their cemeteries, by combining their data we achieved more comprehensive and representative data on death among Iranian people...
February 5, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29404184/cross-cultural-adaptation-and-validation-of-beliefs-about-medicines-questionnaire-on-asthma-and-chronic-obstructive-pulmonary-disease-patients
#16
Hüseyin Arıkan, Dildar Duman, Feyza Kargın, Gülbin Ergin, Rob Horne, Sait Karakurt, Emel Eryüksel
OBJECTIVES: Inadequate adaptation to long-term treatment of chronic illnesses is the most common reason for the inability to obtain the benefits medications can provide. Treatment compliance is influenced by several factors. Beliefs about Medicines Questionnaire (BMQ) developed by Horne et al. in 1999 to evaluate the cognitive representation of medicines have many validation studies, which resulted in good psychometric properties. The aim of the present study was to evaluate the reliability and validity of the BMQ Turkish translation in patients with asthma and chronic obstructive pulmonary disease (COPD)...
January 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29404157/to-investigate-the-effects-of-air-pollution-pm10-and-so2-on-the-respiratory-diseases-asthma-and-chronic-obstructive-pulmonary-disease
#17
Mustafa Saygın, Taner Gonca, Önder Öztürk, Mehmet Has, Sadettin Çalışkan, Zehra Güliz Has, Ahmet Akkaya
OBJECTIVES: Effects of air pollution parameters of sulfur dioxide (SO2) and particulate matter (PM10) values on the respiratory system were investigated. MATERIAL AND METHODS: Data of SO2 and PM10 were obtained daily for air pollution and classified into two groups: Group I (2006-2007), coal burning years and Group II (2008-2009), natural gas+ coal burning. Groups I and II were divided into two subgroups according to the months of combustion as combustible (November-April) and noncombustible (May-October)...
April 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29382628/using-the-inflammacheck-device-to-measure-the-level-of-exhaled-breath-condensate-hydrogen-peroxide-in-patients-with-asthma-and-chronic-obstructive-pulmonary-disease-the-exhale-pilot-study-protocol-for-a-cross-sectional-feasibility-study
#18
Daniel M Neville, Carole Fogg, Thomas P Brown, Thomas L Jones, Eleanor Lanning, Paul Bassett, Anoop J Chauhan
BACKGROUND: Asthma and Chronic Obstructive Pulmonary Disease (COPD) are common conditions that affect over 5 million people in the United Kingdom. These groups of patients suffer significantly from breathlessness and recurrent exacerbations that can be difficult to diagnose and go untreated. A common feature of COPD and asthma is airway inflammation that increases before and during exacerbations. Current methods of assessing airway inflammation can be invasive, difficult to perform, and are often inaccurate...
January 30, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29381185/nya-kriterier-f%C3%A3-r-astma-kol-mottagningar-i-prim%C3%A3-rv%C3%A3-rden-patientutbildning-r%C3%A3-kslutarst%C3%A3-d-och-fysisk-aktivitet-%C3%A3-r-prioriterat-%C3%A2-%C3%A3-ven-fysioterapeut-b%C3%A3-r-inkluderas-i-teamet
#19
Inger Kull, Björn Ställberg
Updated criterias for an asthma/COPD clinic in primary care based on Swedish guidelines We here present updated criterias for an asthma/COPD clinic in primary care based on Swedish guidelines and an estimate of the time required for its tasks. Certified staff should assist in diagnosis and follow-up of asthma/COPD patients, provide patient education, provide and follow up written management plans, facilitate smoking cessation in patients and parents of children with asthma, evaluate symptoms with validated tools (ACT, CAT), and assess and support physical activity...
January 29, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29380068/impedance-oscillometry-emerging-role-in-the-management-of-chronic-respiratory-disease
#20
REVIEW
Mohammed F Zaidan, Ashwini P Reddy, Alexander Duarte
PURPOSE OF REVIEW: Chronic respiratory diseases affecting adults and children are widely prevalent, so lung function testing is imperative for diagnosis and management. Spirometry is the traditional standard measure of lung function; however, certain groups of patients are unable to provide accurate and reproducible exhalation maneuvers. Consequently, the impedance oscillometry system (IOS) has been developed as an effort, independent technique to assess airway function in children and the elderly...
January 29, 2018: Current Allergy and Asthma Reports
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