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https://www.readbyqxmd.com/read/28526671/telehealth-interventions-to-support-self-management-of-long-term-conditions-a-systematic-metareview-of-diabetes-heart-failure-asthma-chronic-obstructive-pulmonary-disease-and-cancer
#1
REVIEW
Peter Hanlon, Luke Daines, Christine Campbell, Brian McKinstry, David Weller, Hilary Pinnock
BACKGROUND: Self-management support is one mechanism by which telehealth interventions have been proposed to facilitate management of long-term conditions. OBJECTIVE: The objectives of this metareview were to (1) assess the impact of telehealth interventions to support self-management on disease control and health care utilization, and (2) identify components of telehealth support and their impact on disease control and the process of self-management. Our goal was to synthesise evidence for telehealth-supported self-management of diabetes (types 1 and 2), heart failure, asthma, chronic obstructive pulmonary disease (COPD) and cancer to identify components of effective self-management support...
May 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28526665/the-sensor-study-protocol-for-a-mixed-methods-study-of-self-management-checks-to-predict-exacerbations-of-pseudomonas-aeruginosa-in-patients-with-long-term-respiratory-conditions
#2
Claire Roberts, Thomas L Jones, Samal Gunatilake, Will Storrar, Scott Elliott, Sharon Glaysher, Ben Green, Steven Rule, Carole Fogg, Ann Dewey, Kevin A Auton, Anoop J Chauhan
BACKGROUND: There are an estimated three million people in the United Kingdom with chronic obstructive pulmonary disease (COPD), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in COPD and severe asthma. Both COPD and bronchiectasis are characterized by exacerbations in which bacteria play a central role. Pseudomonas aeruginosa is isolated from sputum samples from 4% to 15% of adults with COPD and is more likely to be isolated from patients with severe disease...
May 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28523172/roles-of-roflumilast-a-selective-phosphodiesterase-4-inhibitor-in-airway-diseases
#3
REVIEW
Theerasuk Kawamatawong
Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases. Both diseases have incompletely distinct pathophysiology, clinical manifestation, and treatment responsiveness. Pulmonary and systemic inflammations are the hallmarks of COPD. Most asthma responds to inhaled corticosteroid (ICS) treatment. In contrast, COPD is a corticosteroid-resistant disease. Bronchodilators are a preferred treatment method of COPD, with the aim of improving symptoms and preventing exacerbation...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28516352/air-pollution-and-respiratory-health-among-diabetic-and-non-diabetic-subjects-in-pune-india-results-from-the-wellcome-trust-genetic-study
#4
Morteza Abdullatif Khafaie, Sundeep Santosh Salvi, Chittaranjan Sakerlal Yajnik, Ajay Ojha, Behzad Khafaie, Sharad Damodar Gore
Diabetics may be more vulnerable to the harmful effects of ambient air pollutants than healthy individuals. But, the risk factors that lead to susceptibility to air pollution in diabetics have not yet been identified. We examined the effect of exposure to ambient PM10 on chronic symptoms and the pulmonary function tests (PFT) in diabetic and non-diabetic subjects. Also, to investigate possible determinants of susceptibility, we recruited 400 type 2 diabetic and 465 healthy subjects who were investigated for chronic respiratory symptoms (CRSs) and then underwent measurement of forced vital capacity (FVC) and forced expiratory volume 1 (FEV1) according to standard protocol...
May 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28511944/serum-periostin-in-patients-hospitalized-for-copd-exacerbations
#5
Elissavet Konstantelou, Andriana I Papaioannou, Stelios Loukides, Konstantinos Bartziokas, Anastasia Papaporfyriou, Georgios Papatheodorou, Petros Bakakos, Spyros Papiris, Nikolaos Koulouris, Konstantinos Kostikas
Serum periostin has been proposed as a surrogate biomarker of Th2 inflammatory response in patients with asthma, but its predictive role in hospitalized patients with COPD has not been evaluated. The aim of the present observational prospective cohort study was to evaluate the possible role of serum periostin as predictor of outcome in COPD patients hospitalized for AECOPD. Serum periostin was measured on admission and at discharge in patients admitted to the hospital for a COPD exacerbation. Patients were followed-up for 1year for future exacerbations, hospitalizations and mortality...
May 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28511478/recognition-of-small-airways-obstruction-in-asthma-and-copd-the-road-less-travelled
#6
REVIEW
Desh Deepak, Akhila Prasad, Swapndeep Singh Atwal, Kshitij Agarwal
The small airways, once regarded as the silent zone in the air conducting system of the lungs are now known to be one of the initial sites of involvement in diseases like asthma and Chronic Obstructive Pulmonary Disease (COPD). Identification of the involvement of distal airways in these diseases is often difficult to assess, clinically as well as by conventional pulmonary function tests and therefore, usually remains undiscovered in early stages. Early recognition of their involvement in asthma and COPD and timely management may reduce long term morbidity in these conditions...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28507495/the-pharmacotherapy-preferred-by-doctors-in-treatment-of-patients-diagnosed-with-asthma-or-chronic-obstructive-pulmonary-disease-or-allergic-rhinitis-and-concomitant-diseases-an-epidemiological-analysis
#7
Marcin Nowak, Grzegorz Brożek, Zbigniew Doniec, Magdalena Olszanecka-Glinianowicz
INTRODUCTION: The clinical course of asthma and chronic obstructive pulmonary disease (COPD) is influenced by the co-occurrence of other chronic diseases and their pharmacotherapy. There are no data associated with the doctors' pharmacotherapy preferences in treatment of patients with asthma, COPD or allergic rhinitis and concomitant diseases. AIM: The assessment of doctors' preferences in pharmacotherapy of asthma, COPD or allergic rhinitis in relation to concomitant diseases...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28506728/-the-effects-of-inhaled-steroids-withdrawal-in-copd
#8
G Jebrak, I Honore, P Serrier, J Dumoulin, P Terrioux, F Soyez, C Maurer, G Mangiapan, M Febvre, L-J Couderc, J-M Braun, T Chinet
The key pathophysiological feature of chronic obstructive pulmonary disease (COPD) is an abnormal inflammatory bronchial reaction after inhalation of toxic substances. The priority is the avoidance of such toxic inhalations, but the use of anti-inflammatory drugs also seems appropriate, especially corticosteroids that are the sole anti-inflammatory drug available for this purpose in France. The risks associated with the prolonged use of these parenteral drugs are well known. Inhalation is therefore the optimal route, but inhaled drugs may also lead to adverse consequences...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28502841/use-of-airway-epithelial-cell-culture-to-unravel-the-pathogenesis-and-study-treatment-in-obstructive-airway-diseases
#9
REVIEW
Tinne C J Mertens, Harry Karmouty-Quintana, Christian Taube, Pieter S Hiemstra
Asthma and chronic obstructive pulmonary disease (COPD) are considered as two distinct obstructive diseases. Both chronic diseases share a component of airway epithelial dysfunction. The airway epithelium is localized to deal with inhaled substances, and functions as a barrier preventing penetration of such substances into the body. In addition, the epithelium is involved in the regulation of both innate and adaptive immune responses following inhalation of particles, allergens and pathogens. Through triggering and inducing immune responses, airway epithelial cells contribute to the pathogenesis of both asthma and COPD...
May 11, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28502165/grape-seed-proanthocyanidin-inhibits-mucin-synthesis-and-viral-replication-by-suppression-of-ap-1-and-nf-%C3%AE%C2%BAb-via-p38-mapks-jnk-signaling-pathways-in-respiratory-syncytial-virus-infected-a549-cells
#10
Jin-Woo Lee, Young Il Kim, Chang-Nim Im, Sung Wan Kim, Su Jin Kim, Seoyeon Min, Yong Hoon Joo, Sung-Vin Yim, Namhyun Chung
Airway epithelial cells are often infected by respiratory syncytial virus (RSV), one of the most common causes of asthma, bronchiolitis, chronic obstructive pulmonary disease (COPD), and pneumonia. During the infection process, excessive mucins aggravate airway inflammation. However, the mechanism underlying RSV-induced airway hyperresponsiveness and inflammation is poorly understood. Furthermore, no reliable vaccines or drugs for antiviral therapy are available. In this study, the effect of the natural compound grape seed proanthocyanidin (GSP) on RSV-infected human airway epithelial cells A549 was evaluated...
May 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28499580/transient-receptor-potential-trp-channels-as-molecular-targets-in-lung-toxicology-and-associated-diseases
#11
REVIEW
Alexander Dietrich, Dirk Steinritz, Thomas Gudermann
The lungs as the gateways of our body to the external environment are essential for gas exchange. They are also exposed to toxicants from two sides, the airways and the vasculature. Apart from naturally produced toxic agents, millions of human made chemicals were produced since the beginning of the industrial revolution whose toxicity still needs to be determined. While the knowledge about toxic substances is increasing only slowly, a paradigm shift regarding the proposed mechanisms of toxicity at the plasma membrane emerged...
April 26, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28495687/phenotypes-of-copd-patients-with-a-smoking-history-in-central-and-eastern-europe-the-pope-study
#12
Vladimir Koblizek, Branislava Milenkovic, Adam Barczyk, Ruzena Tkacova, Attila Somfay, Kirill Zykov, Neven Tudoric, Kosta Kostov, Zuzana Zbozinkova, Jan Svancara, Jurij Sorli, Alvils Krams, Marc Miravitlles, Arschang Valipour
Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region.Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28495077/consensus-on-the-asthma-copd-overlap-syndrome-acos-between-the-spanish-copd-guidelines-gesepoc-and-the-spanish-guidelines-on-the-management-of-asthma-gema
#13
Vicente Plaza, Francisco Álvarez, Myriam Calle, Ciro Casanova, Borja G Cosío, Antolín López-Viña, Luís Pérez de Llano, Santiago Quirce, Miguel Román-Rodríguez, Juan José Soler-Cataluña, Marc Miravitlles
Following a proposal by the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR), sponsor of the Spanish COPD Guidelines (GesEPOC) and the Spanish Guidelines on the Management of Asthma (GEMA), authors of both papers have unified the criteria for the diagnosis of asthma-COPD overlap syndrome (ACOS). This consensus defines ACOS as the presence in a given patient of three elements: significant smoking exposure, chronic airflow limitation and asthma. Diagnosis is confirmed when a patient (35years of age or older), smoker or ex-smoker of more than 10 pack-years, presents airflow limitation (post-bronchodilator FEV1/FVC<0...
May 8, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28494181/characterization-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-a-qualitative-analysis
#14
Claudie Rodrigue, Marie-France Beauchesne, Valérie Mallette, Catherine Lemière, Pierre Larivée, Lucie Blais
Approximately 15-20% of patients with chronic obstructive pulmonary disease (COPD) also display characteristics of asthma. In May 2014, the asthma-COPD overlap syndrome (ACOS) was briefly addressed in the Global Initiative for Asthma (GINA) and Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy documents. We evaluated how pulmonologists diagnose and treat ACOS and how they assess its control. Pulmonologists from two university healthcare centers, having ≥ 1 year experience, treating patients with asthma, COPD, or ACOS, were invited to participate in focus groups...
May 11, 2017: COPD
https://www.readbyqxmd.com/read/28490870/pre-and-post-bronchodilator-airway-obstruction-are-associated-with-similar-clinical-characteristics-but-different-prognosis-report-from-a-population-based-study
#15
Sami Sawalha, Linnea Hedman, Eva Rönmark, Bo Lundbäck, Anne Lindberg
INTRODUCTION: According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortality, between subjects with airway obstruction divided into pre- but not post-BD obstruction, post-BD airway obstruction (COPD), and subjects without airway obstruction...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28489443/book-reviews-pharmacology-and-therapeutics-of-asthma-and-copd-edited-by-clive-p-page-peter-j-barnes-springer-2017-price-%C3%A2-278-50-pp-285-isbn-978-3-319-52173-2-oxford-handbook-of-infectious-diseases-and-microbiology-2nd-edn-estee-torok-ed-moran-fiona-cooke-oxford
#16
https://www.readbyqxmd.com/read/28487516/peak-flow-meter-with-a-questionnaire-and-mini-spirometer-to-help-detect-asthma-and-copd-in-real-life-clinical-practice-a-cross-sectional-study
#17
Yogesh T Thorat, Sundeep S Salvi, Rahul R Kodgule
Peak flow meter with questionnaire and mini-spirometer are considered as alternative tools to spirometry for screening of asthma and chronic obstructive pulmonary disease. However, the accuracy of these tools together, in clinical settings for disease diagnosis, has not been studied. Two hundred consecutive patients with respiratory complaints answered a short symptom questionnaire and performed peak expiratory flow measurements, standard spirometry with Koko spirometer and mini-spirometry (COPD-6). Spirometry was repeated after bronchodilation...
May 9, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28484832/accuracy-of-routinely-collected-comorbidity-data-in-patients-undergoing-colectomy-a-retrospective-study
#18
Shahin Hajibandeh, Shahab Hajibandeh, Roger Deering, Dearbhla McEleney, John Guirguis, Sarah Dix, Abdelhakem Sreh, Afsana Kausar
OBJECTIVES: This paper aimed to determine the baseline accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of routinely collected comorbidity data in patients undergoing any types of colectomy. METHODS: All patients aged >18 who underwent right hemicolectomy, left hemicolectomy, sigmoid colectomy, subtotal colectomy, or total colectomy between 1 January 2015 and 1 November 2016 were identified. The following comorbidities were considered: hypertension, ischemic heart disease (IHD), diabetes, asthma, chronic obstructive pulmonary disease (COPD), cerebrovascular disease (CVD), chronic kidney disease (CKD), and hypercholesterolemia...
May 8, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28482883/rescue-medication-use-as-a-patient-reported-outcome-in-copd-a-systematic-review-and-regression-analysis
#19
Yogesh Suresh Punekar, Sheetal Sharma, Ankit Pahwa, Jitender Takyar, Ian Naya, Paul W Jones
BACKGROUND: Reducing rescue medication use is a guideline-defined goal of asthma treatment, however, little is known about the validity of rescue medicine use as a marker of symptoms in chronic obstructive pulmonary disease (COPD). To improve patient outcomes, greater insight is needed into the relationship between rescue medication use and alternative COPD outcomes. METHODS: A systematic search of electronic databases (Embase®, MEDLINE® and Cochrane CENTRAL) was conducted from database start to 26 May, 2015...
May 8, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28481637/hydrogen-sulfide-a-novel-player-in-airway-development-pathophysiology-of-respiratory-diseases-and-antiviral-defenses
#20
Nikolay Bazhanov, Maria Ansar, Teodora Ivanciuc, Roberto P Garofalo, Antonella Casola
Hydrogen sulfide (H2S) is a biologically relevant signaling molecule in mammals. Together with the volatile substances nitric oxide (NO) and carbon monoxide (CO), H2S is defined as a gasotransmitter, playing a physiological role in a variety of functions such as synaptic transmission, vascular tone, angiogenesis, inflammation and cellular signaling. The generation of H2S is catalyzed by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3 mercaptopyruvate sulfurtransferase (3-MST). The expression of CBS and CSE is tissue-specific with CBS being expressed predominantly in the brain and CSE in peripheral tissues, including lungs...
May 8, 2017: American Journal of Respiratory Cell and Molecular Biology
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