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https://www.readbyqxmd.com/read/29666970/histopathological-and-molecular-predictors-of-growth-patterns-and-recurrence-in-craniopharyngiomas-a-systematic-review
#1
REVIEW
Josephine R Coury, Brittany N Davis, Christoforos P Koumas, Giovanna S Manzano, Amir R Dehdashti
Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecular characteristics are prognostic for disease progression. In this systematic review, we analyzed and consolidated key features of CPs that contribute to increased recurrence rates. This systematic review was performed in accordance with PRISMA guidelines...
April 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29666520/identification-and-characterization-of-bioactive-phenolic-constituents-anti-proliferative-and-anti-angiogenic-activity-of-stem-extracts-of-basella-alba-and-rubra
#2
B Ramesh Kumar, Apoorva Anupam, Padmavati Manchikanti, Arun Prabhu Rameshbabu, Swagata Dasgupta, Santanu Dhara
Basella is an important green leafy vegetable species of Chenopodiaceae family and is known for its medicinal properties. Hydroxy-benzoic acids, hydroxy-cinnamic acids and flavones groups were identified and characterized from the aqueous stem extracts of B. alba and B. rubra species. Higher values of phenolics as well as antioxidant activity were noted from B. alba species extracts. The evaluation of the cytoxicity of these extracts on A431 (epidermoid carcinoma), Hep G2 (hepatocellular carcinoma) and MG 63 (osteosarcoma) cells indicated anti-proliferative activity against all the cell lines...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666450/novel-hla-class-i-associations-with-hiv-1-control-in-a-unique-genetically-admixed-population
#3
Humberto Valenzuela-Ponce, Selma Alva-Hernández, Daniela Garrido-Rodríguez, Maribel Soto-Nava, Thalía García-Téllez, Tania Escamilla-Gómez, Claudia García-Morales, Verónica Sonia Quiroz-Morales, Daniela Tapia-Trejo, Silvia Del Arenal-Sánchez, Francisco-Javier Prado-Galbarro, Ramón Hernández-Juan, Edna Rodríguez-Aguirre, Akio Murakami-Ogasawara, Carlos Mejía-Villatoro, Ingrid Y Escobar-Urias, Rodolfo Pinzón-Meza, Juan Miguel Pascale, Yamitzel Zaldivar, Guillermo Porras-Cortés, Carlos Quant-Durán, Ivette Lorenzana, Rita I Meza, Elsa Y Palou, Marvin Manzanero, Rolando A Cedillos, Carmen Aláez, Mark A Brockman, P Richard Harrigan, Chanson J Brumme, Zabrina L Brumme, Santiago Ávila-Ríos, Gustavo Reyes-Terán
Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian and Caucasian genetic admixture remain understudied. Using univariable and multivariable analyses we evaluated HLA associations with five HIV clinical parameters in 3,213 HIV clade B-infected, ART-naïve individuals from Mexico and Central America (MEX/CAM cohort). A Canadian cohort (HOMER, n = 1622) was used for comparison. As expected, HLA allele frequencies in MEX/CAM and HOMER differed markedly. In MEX/CAM, 13 HLA-A, 24 HLA-B, and 14 HLA-C alleles were significantly associated with at least one clinical parameter...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666364/improved-calcium-sensor-gcamp-x-overcomes-the-calcium-channel-perturbations-induced-by-the-calmodulin-in-gcamp
#4
Yaxiong Yang, Nan Liu, Yuanyuan He, Yuxia Liu, Lin Ge, Linzhi Zou, Sen Song, Wei Xiong, Xiaodong Liu
GCaMP, one popular type of genetically-encoded Ca2+ indicator, has been associated with various side-effects. Here we unveil the intrinsic problem prevailing over different versions and applications, showing that GCaMP containing CaM (calmodulin) interferes with both gating and signaling of L-type calcium channels (CaV 1). GCaMP acts as an impaired apoCaM and Ca2+ /CaM, both critical to CaV 1, which disrupts Ca2+ dynamics and gene expression. We then design and implement GCaMP-X, by incorporating an extra apoCaM-binding motif, effectively protecting CaV 1-dependent excitation-transcription coupling from perturbations...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29663486/calmodulin-antagonist-enhances-dr5-mediated-apoptotic-signaling-in-tra-8-resistant-triple-negative-breast-cancer-cells
#5
Romone M Fancy, Harrison Kim, Tiara Napier, Donald J Buchsbaum, Kurt R Zinn, Yuhua Song
Patients with triple negative breast cancer (TNBC) have no successful "targeted" treatment modality, which represents a priority for novel therapy strategies. Upregulated death receptor 5 (DR5) expression levels in breast cancer cells compared to normal cells enable TRA-8, a DR5 specific agonistic antibody, to specifically target malignant cells for apoptosis without inducing normal hepatocyte apoptosis. Drug resistance is a common obstacle in TRAIL-based therapy for TNBC. Calmodulin (CaM) is overexpressed in breast cancer...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29662864/expression-of-adhesion-molecules-on-cd34-cells-from-steady-state-bone-marrow-before-and-after-mobilization-and-their-association-with-the-yield-of-cd34-cells
#6
Karin Zattar Cecyn, Eliza Y S Kimura, Dulce Marta S M Lima, Miyoko Yamamoto, José Orlando Bordin, José Salvador R de Oliveira
Background: Cell adhesion molecules (CAMs) expressed on hematopoietic progenitor cells (HPCs), endothelial cells, and stromal cells play a pivotal role in the mobilization of CD34+ cells. Herein, we conducted a non-randomized peripheral blood stem cell (PBSC) mobilization study aimed to compare the potential differences in the expressions of several CAMs and chemokines on CD34+ cells obtained from bone marrow aspirate before and after HPC mobilization from patients with hematologic malignancies and healthy donors...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662633/tracking-cellular-and-molecular-changes-in-a-species-specific-manner-during-experimental-tumor-progression-in-vivo
#7
Emilie Indersie, Katarzyna B Hooks, Caroline Capdevielle, Monique Fabre, Nathalie Dugot-Senant, Angélique Desplat, Sébastien Lepreux, Aksam Merched, Christophe F Grosset, Martin Hagedorn
Hepatoblastoma (HBL) is a pediatric liver cancer with defined molecular alterations driving its progression. Here, we describe an animal model for HBL on the chick chorioallantoic membrane (CAM), which recapitulates relevant features of HBL in patients. Expression of classic tumor-associated proteins such as β-catenin, EpCAM and CK19 was maintained in acini-like organized tumors on CAM, as was synthesis of AFP, a tumor marker used for monitoring patient response. RNA sequencing revealed an unexpected molecular evolution of HBL cells on the CAM, with significant deregulation of more than 6,000 genes including more than half of all HOX genes...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662310/in-vitro-vivo-drug-release-and-anti-diabetic-cardiomyopathy-properties-of-curcumin-pblg-peg-pblg-nanoparticles
#8
Fei Tong, Rongkui Chai, Haiying Jiang, Bo Dong
Background: The objective of this study was to survey the therapeutic function of curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect of calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2 S). Methods: Diabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29662082/hadd-a-novel-fatty-acid-synthase-type-ii-protein-is-essential-for-alpha-and-epoxy-mycolic-acid-biosynthesis-and-mycobacterial-fitness
#9
Cyril Lefebvre, Richard Boulon, Manuelle Ducoux, Sabine Gavalda, Françoise Laval, Stevie Jamet, Nathalie Eynard, Anne Lemassu, Kaymeuang Cam, Marie-Pierre Bousquet, Fabienne Bardou, Odile Burlet-Schiltz, Mamadou Daffé, Annaïk Quémard
Mycolic acids (MAs) have a strategic location within the mycobacterial envelope, deeply influencing its architecture and permeability, and play a determinant role in the pathogenicity of mycobacteria. The fatty acid synthase type II (FAS-II) multienzyme system is involved in their biosynthesis. A combination of pull-downs and proteomics analyses led to the discovery of a mycobacterial protein, HadD, displaying highly specific interactions with the dehydratase HadAB of FAS-II. In vitro activity assays and homology modeling showed that HadD is, like HadAB, a hot dog folded (R)-specific hydratase/dehydratase...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661579/effect-of-acid-etching-on-tridimensional-microstructure-of-etchable-cad-cam-materials
#10
Fabián Murillo-Gómez, Regina Guenka Palma-Dibb, Mario Fernando De Goes
OBJECTIVE: Evaluate if etching protocols affect superficial/internal microstructural integrity of CAD/CAM ceramic materials. METHODS: Sixty blocks (3×3×3mm) of IPS/Empress-LEU, IPS/e.max-LDC (Ivoclar-Vivadent) and Enamic-PIC (VITA) were used. Lateral surfaces from each block were isolated with Teflon strip and petroleum jelly to keep them untouched. Specimens were distributed into 6 groups (n=10): 1. no treatment (C); 2. hydrofluoric acid (HF) 5%, 20s (HF5%20s); 3...
April 13, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29660274/plane-wave-implementation-and-performance-of-%C3%A3-la-carte-coulomb-attenuated-exchange-correlation-functionals-for-predicting-optical-excitation-energies-in-some-notorious-cases
#11
Martin Peter Bircher, Ursula Rothlisberger
Linear-response time-dependent density functional theory (LR-TDDFT) has become a valuable tool in the calculation of excited states of molecules of various sizes. However, standard generalised gradient approximation (GGA) and hybrid exchange-correlation (xc) functionals often fail to correctly predict charge-transfer (CT) excitations with low orbital overlap, thus limiting the scope of the method. The Coulomb-attenuation method (CAM) in the form of the CAM-B3LYP functional has been shown to reliably remedy this problem in many CT systems, making accurate predictions possible...
April 16, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29660114/molecular-evolution-of-key-metabolic-genes-during-transitions-to-c-4-and-cam-photosynthesis
#12
Eric W Goolsby, Abigail J Moore, Lillian P Hancock, Jurriaan M De Vos, Erika J Edwards
PREMISE OF THE STUDY: Next-generation sequencing facilitates rapid production of well-sampled phylogenies built from very large genetic data sets, which can then be subsequently exploited to examine the molecular evolution of the genes themselves. We present an evolutionary analysis of 83 gene families (19 containing carbon-concentrating mechanism (CCM) genes, 64 containing non-CCM genes) in the portullugo clade (Caryophyllales), a diverse lineage of mostly arid-adapted plants that contains multiple evolutionary origins of all known photosynthesis types in land plants (C3 , C4 , CAM, C4 -CAM, and various intermediates)...
April 16, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29659538/cell-adhesion-molecules-are-mediated-by-photobiomodulation-at-660-nm-in-diabetic-wounded-fibroblast-cells
#13
Nicolette N Houreld, Sandra M Ayuk, Heidi Abrahamse
Diabetes affects extracellular matrix (ECM) metabolism, contributing to delayed wound healing and lower limb amputation. Application of light (photobiomodulation, PBM) has been shown to improve wound healing. This study aimed to evaluate the influence of PBM on cell adhesion molecules (CAMs) in diabetic wound healing. Isolated human skin fibroblasts were grouped into a diabetic wounded model. A diode laser at 660 nm with a fluence of 5 J/cm² was used for irradiation and cells were analysed 48 h post-irradiation...
April 16, 2018: Cells
https://www.readbyqxmd.com/read/29658069/nine-prophylactic-polishing-pastes-impact-on-discoloration-gloss-and-surface-properties-of-a-cad-cam-resin-composite
#14
Anja Liebermann, Sebastian Spintzyk, Marcel Reymus, Ernst Schweizer, Bogna Stawarczyk
OBJECTIVES: To investigate discoloration reduction and changes of surface properties of a CAD/CAM resin composite after 14 days´ storage in red wine and polishing with nine different prophylactic polishing pastes (PPPs). MATERIALS AND METHODS: Rectangular discs (N = 172) were fabricated and polished (P4000) using GC Cerasmart (GC Europe) to investigate different polishing protocols with 1-4 related descending PPPs (22 in total): Cleanic/CLE-Kerr, CleanJoy/CLJ-Voco, Clean Polish/Super Polish/SPO-Kerr, Clinpro Prophy Paste/CPP-3M, Détartrine/DET-Septodont, Nupro/NUP-Dentsply Sirona, Prophy Paste CCS/CCS-Directa, Proxyt/PXT-Ivoclar Vivadent, and Zircate/ZIR Prophy Paste-Dentsply Sirona...
April 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29657843/impingement-around-the-hip-beyond-cam-and-pincer
#15
Niels Hendrik Bech, Daniel Haverkamp
In this review, we bring to the attention of the reader three relatively unknown types of hip impingement. We explain the concept of low anterior inferior iliac spine (AIIS) impingement, also known as sub-spine impingement, ischio-femoral impingement (IFI) and pelvi-trochanteric impingement. For each type of impingement, we performed a search of relevant literature.We searched the PubMed, Medline (Ovid) and Embase databases from 1960 to March 2016. For each different type of impingement, a different search strategy was conducted...
February 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29657537/analysis-of-vertical-marginal-discrepancy-in-feldspathic-porcelain-crowns-manufactured-with-different-cad-cam-systems-closed-and-open
#16
Fabio Kricheldorf, Cleuber Rodrigo de Souza Bueno, Wilson da Silva Amaral, Joel Ferreira Santiago Junior, Hugo Nary Filho
Objective: The objective of this study is to compare the marginal adaptation of feldspathic porcelain crowns using two computer-aided design/computer-aided manufacturing systems, one of them is open and the other is closed. Materials and Methods: Twenty identical titanium abutments were divided into two groups: open system (OS), where ceramic crowns were created using varied equipment and software, and closed system (CS), where ceramic crowns were created using the CEREC system...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29657528/digital-versus-conventional-techniques-for-pattern-fabrication-of-implant-supported-frameworks
#17
Marzieh Alikhasi, Ahmad Rohanian, Safoura Ghodsi, Amin Mohammadpour Kolde
Objective: The aim of this experimental study was to compare retention of frameworks cast from wax patterns fabricated by three different methods. Materials and Methods: Thirty-six implant analogs connected to one-piece abutments were divided randomly into three groups according to the wax pattern fabrication method ( n = 12). Computer-aided design/computer-aided manufacturing (CAD/CAM) milling machine, three-dimensional printer, and conventional technique were used for fabrication of waxing patterns...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29657370/delirium-in-the-intensive-care-unit-incidence-risk-factors-and-impact-on-outcome
#18
Nejla Tilouche, Mohamed Fekih Hassen, Habiba Ben Sik Ali, Oussamma Jaoued, Rim Gharbi, S Souheil El Atrous
Background: The incidence and risk factors for delirium vary among studies. Objective: We aimed to determine the incidence, risk factors, and impact on outcome of delirium in a medical Intensive Care Unit (ICU) in Tunisia using a prospective observational study. Patients: All consecutive patients admitted to the ICU between May 2012 and April 2013 were included if they were aged more than 18 years and had an ICU stay of more than 24 h. Patients who had a cardiac arrest or have a history of dementia or psychosis were excluded...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29656985/in-silico-analysis-of-the-potential-mechanism-of-telocinobufagin-on-breast-cancer-mcf-7-cells
#19
Yi-Wu Dang, Peng Lin, Li-Min Liu, Rong-Quan He, Li-Jie Zhang, Zhi-Gang Peng, Xiao-Jiao Li, Gang Chen
BACKGROUNDS AND AIMS: The extractives from a ChanSu, traditional Chinese medicine, have been discovered to possess anti-inflammatory and tumor-suppressing abilities. However, the molecular mechanism of telocinobufagin, a compound extracted from ChanSu, on breast cancer cells has not been clarified. The aim of this study is to investigate the underlying mechanism of telocinobufagin on breast cancer cells. METHODS AND MATERIALS: The differentially expressed genes after telocinobufagin treatment on breast cancer cells were searched and downloaded from Gene Expression Omnibus (GEO), ArrayExpress and literatures...
April 5, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29656594/immune-imbalance-of-global-gene-expression-and-cytokine-chemokine-and-selectin-levels-in-the-brains-of-offspring-with-social-deficits-via-maternal-immune-activation
#20
Pei-Tan Hsueh, Hsi-Hsun Lin, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Jong-Kang Liu, Hsin-Hou Chang, Der-Shan Sun, Yao-Shen Chen, Ya-Lei Chen
The murine maternal immune activation (MIA) offspring model enables longitudinal studies to explore aberrant social behaviors similar to those observed in humans. High levels of cytokines, chemokines and cell adhesion molecules (CAM) have been found in the plasma and/or brains of psychiatric patients. We hypothesized that up-regulation of the systemic or brain immune response has an augmenting effect by potentially increasing the interplay between the neuronal and immune systems during the growth of the MIA offspring...
April 15, 2018: Genes, Brain, and Behavior
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