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https://www.readbyqxmd.com/read/27905860/a-scoping-review-on-models-of-integrative-medicine-what-is-known-from-the-existing-literature
#1
Eun Jin Lim, Janette L Vardy, Byeong Sang Oh, Haryana M Dhillon
OBJECTIVES: Integrative medicine (IM) has been recognized and introduced into Western healthcare systems over the past two decades. Limited information on IM models is available to guide development of an optimal healthcare service. A scoping review was carried out to evaluate IM models in the extant literature, including the distinctive features of each model, to gain an understanding of the core requirements needed to develop models of IM that best meet the needs of patients. DESIGN: Directed content analysis was used to classify the IM models into systems based on coding schema developed from theoretical models and to identify the key concepts of each system...
December 1, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27904489/speech-and-language-therapy-for-aphasia-following-subacute-stroke
#2
Engin Koyuncu, Pınar Çam, Nermin Altınok, Duygu Ekinci Çallı, Tuba Yarbay Duman, Neşe Özgirgin
The aim of this study was to investigate the time window, duration and intensity of optimal speech and language therapy applied to aphasic patients with subacute stroke in our hospital. The study consisted of 33 patients being hospitalized for stroke rehabilitation in our hospital with first stroke but without previous history of speech and language therapy. Sixteen sessions of impairment-based speech and language therapy were applied to the patients, 30-60 minutes per day, 2 days a week, for 8 successive weeks...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27903990/baicalein-reduces-angiogenesis-in-the-inflammatory-microenvironment-via-inhibiting-the-expression-of-ap-1
#3
Yujie Huang, Zhaorui Miao, Yang Hu, Yang Yuan, Yuxin Zhou, Libin Wei, Kai Zhao, Qinglong Guo, Na Lu
Increasing clinical and experimental studies have demonstrated that refractory chronic inflammation will result in malignant tumor and anti-angiogenic therapy may be an effective way to thwart the progression. Baicalein, one of the major active flavanoids found in Scutellaria baicalensis Georgi, has been exhibited potent anti-inflammation and anti-tumor effects by reducing angiogenesis. However, the exact mechanism of baicalein on endothelial cells in inflammatory microenvironment was not clear yet. Here, we investigated the anti-angiogenic effect of baicalein by incubating human umbilical vein endothelial cells (HUVECs) with THP-1 conditioned medium in vitro...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27903592/alpha-angle-measurements-in-healthy-adult-volunteers-vary-depending-on-the-mri-plane-acquisition-used
#4
Mohammad Golfam, Luigia A Di Primio, Paul E Beaulé, Kalesha Hack, Mark E Schweitzer
BACKGROUND: It has been shown that cam deformities are located at a more anterosuperior location than was previously described. PURPOSE: To establish, in a large group of asymptomatic participants, the normative range of the alpha angle in the anterosuperior location in both the oblique axial and radial views of magnetic resonance imaging (MRI). STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: In 197 asymptomatic participants (394 asymptomatic hips) with a mean age of 29...
November 9, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27903506/is-the-hip-capsule-thicker-in-diseased-hips
#5
K S Rakhra, A A Bonura, R Nairn, M E Schweitzer, N M Kolanko, P E Beaule
OBJECTIVES: The purpose of this study was to compare the thickness of the hip capsule in patients with surgical hip disease, either with cam-femoroacetabular impingement (FAI) or non-FAI hip pathology, with that of asymptomatic control hips. METHODS: A total of 56 hips in 55 patients underwent a 3Tesla MRI of the hip. These included 40 patients with 41 hips with arthroscopically proven hip disease (16 with cam-FAI; nine men, seven women; mean age 39 years, 22 to 58) and 25 with non-FAI chondrolabral pathology (four men, 21 women; mean age 40 years, 18 to 63) as well as 15 asymptomatic volunteers, whose hips served as controls (ten men, five women; mean age 62 years, 33 to 77)...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27902752/dose-dependent-dual-effect-of-baicalin-and-herb-huang-qin-extract-on-angiogenesis
#6
Dongqing Zhu, Shanshan Wang, John Lawless, Jianchen He, Zhengui Zheng
Huang Qin (root of Scutellaria baicalensis) is a widely used herb in different countries for adjuvant therapy of inflammation, diabetes, hypertension, different kinds of cancer and virus related diseases. Baicalin is the main flavonoid in this herb and has been extensively studied for 30 years. The angiogenic effect of herb Huang Qin extract and baicalin was found 13 years ago, however, the results were controversial with pro-angiogenic effect in some studies and anti-angiogenic effect in others. In this paper, the angiogenic effect of baicalin, its aglycone form baicalein and aqueous extract of Huang Qin was studied in chick embryo chorioallantoic membrane (CAM) model...
2016: PloS One
https://www.readbyqxmd.com/read/27902171/treatment-of-mixed-type-femoroacetabular-impingement-using-safe-surgical-hip-dislocation-in-adults
#7
Ulukan İnan, Selim Harmanşa, Hakan Ömeroğlu
OBJECTIVES: This study aims to assess the experience gained in a single institution in the treatment of mixed type femoroacetabular impingement (FAI) using safe surgical hip dislocation (SSHD) technique. PATIENTS AND METHODS: In this study, 22 hips of 21 patients (7 males, 14 females; mean age 33.8±10.6 years; range 19-52 years) treated by SSHD technique in our clinic between October 2009 and October 2014 were retrospectively evaluated. Preoperative and final Harris hip scores (HHS) and alpha angles were compared...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27897328/solid-phase-extraction-with-metal-organic-frameworks-for-the-analysis-of-chiral-compounds
#8
Bo Tang, Jun-Hui Zhang, Min Zi, Xue-Xian Chen, Li-Ming Yuan
Metal-organic frameworks (MOFs) are excellent porous materials with nanoscale cavities and high surface areas, which make them promising as novel adsorbents in solid-phase extraction (SPE). In this article we report a new application of the chiral MOF [Zn2 (D-Cam)2 (4,4'-bpy)]n in SPE used for the measurement of the enantiomeric excess (ee) of (±)-1,1'-bi-2-naphthol. Several important experimental parameters that may influence the extraction efficiency were investigated and optimized. Under the optimum conditions, a good linearity (R(2)  > 0...
December 2016: Chirality
https://www.readbyqxmd.com/read/27895744/identification-of-targets-of-mirna-221-and-mirna-222-in-fulvestrant-resistant-breast-cancer
#9
Pengfei Liu, Manna Sun, Wenhua Jiang, Jinkun Zhao, Chunyong Liang, Huilai Zhang
The present study aimed to identify the differentially expressed genes (DEGs) regulated by microRNA (miRNA)-221 and miRNA-222 that are associated with the resistance of breast cancer to fulvestrant. The GSE19777 transcription profile was downloaded from the Gene Expression Omnibus database, and includes data from three samples of antisense miRNA-221-transfected fulvestrant-resistant MCF7-FR breast cancer cells, three samples of antisense miRNA-222-transfected fulvestrant-resistant MCF7-FR cells and three samples of control inhibitor (green fluorescent protein)-treated fulvestrant-resistant MCF7-FR cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894589/discovery-and-preclinical-evaluation-of-7-benzyl-n-substituted-pyrrolo-3-2-d-pyrimidin-4-amines-as-single-agents-with-microtubule-targeting-effects-along-with-triple-acting-angiokinase-inhibition-as-antitumor-agents
#10
Roheeth Kumar Pavana, Shruti Choudhary, Anja Bastian, Michael A Ihnat, Ruoli Bai, Ernest Hamel, Aleem Gangjee
The utility of cytostatic antiangiogenic agents (AA) in cancer chemotherapy lies in their combination with cytotoxic chemotherapeutic agents. Clinical combinations of AA with microtubule targeting agents (MTAs) have been particularly successful. The discovery, synthesis and biological evaluations of a series of 7-benzyl-N-substituted-pyrrolo[3,2-d]pyrimidin-4-amines are reported. Novel compounds which inhibit proangiogenic receptor tyrosine kinases (RTKs) including vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β) and epidermal growth factor receptor (EGFR), along with microtubule targeting in single molecules are described...
November 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27894082/the-disintegrin-echistatin-in-combination-with-doxorubicin-targets-high-metastatic-human-osteosarcoma-overexpressing-%C3%AE-%C3%AE-%C3%AE-3-integrin-in-chick-embryo-and-nude-mouse-models
#11
Yasunori Tome, Hiroaki Kimura, Naotoshi Sugimoto, Hiroyuki Tsuchiya, Fuminori Kanaya, Michael Bouvet, Robert M Hoffman
Echistatin, a cyclic RGD peptide, which is an antagonist of αvβ3 integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model. A high-metastatic variant of human osteosarcoma, 143B-LM4, overexpressing αvβ3 integrin was used. Tumor angiogenesis by high-metastatic variant 143B-LM4 cells in the CAM was significantly inhibited by echistatin (P<0.05) as was overall growth. A doxorubicin (DOX)-echistatin combination inhibited orthotopic tumor growth compared to untreated control (P<0...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27892837/conservative-anterior-partial-coverage-cad-cam-restoration
#12
J T May
Computer-aided design and manufacturing technology enables practitioners to create, in a single appointment, indirect restorations that are esthetic and functionally unique to the patient's situation. The popular effort to perform minimally invasive dentistry using digital techniques with chairside milling can lead dentists to novel individualized restorative treatment. This article demonstrates a conservative anterior partial coverage restoration, utilizing both digital technology and chairside ceramic characterization to achieve an optimal esthetic outcome while preserving healthy tooth structure...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27892682/can-serum-icam-1-distinguish-pancreatic-cancer-from-chronic-pancreatitis
#13
amal mohamed, Yasmine Saad, Doaa Saleh, Rehab Elawady, Rasha Eletreby, Ahmad Khairalla, Eman Badr
Background and aim: Pancreatic cancer is the fourth leading cause of cancer-related death worldwide, with an overall 5-year survival of <5% mainly due to presence of advanced disease at time of diagnosis. Therefore development of valid biomarkers to diagnose pancreatic cancer in early stages is an urgent need. This study concerned the sensitivity and specificity of serum ICAM 1 versus CA 19-9 in differentiation between pancreatic cancer and healthy subjects and acohort of patients with chronic pancreatitis with a focus on assessing validity in diagnosis of early stages of pancreatic cancer...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27892564/zirconia-based-dental-ceramics-structure-mechanical-properties-biocompatibility-and-applications
#14
Chandkiram Gautam, Jarin Joyner, Amarendra Gautam, Jitendra Rao, Robert Vajtai
Zirconia (ZrO2) based dental ceramics have been considered to be advantageous materials with adequate mechanical properties for the manufacturing of medical devices. Due to its very high compression strength of 2000 MPa, ZrO2 can resist differing mechanical environments. During the crack propagation on the application of stress on the surface of ZrO2, a crystalline modification diminishes the propagation of cracks. In addition, zirconia's biocompatibility has been studied in vivo, leading to the observation of no adverse response upon the insertion of ZrO2 samples into the bone or muscle...
November 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27891569/chair-side-generated-posterior-monolithic-lithium-disilicate-crowns-clinical-survival-after-6%C3%A2-years
#15
Angelika Rauch, Sven Reich, Oliver Schierz
OBJECTIVES: The objective of this prospective clinical study was to evaluate the clinical performance of chair-side generated monolithic lithium disilicate crowns after 72 months. MATERIALS AND METHODS: Forty-one posterior full contour crowns made of lithium disilicate ceramic were inserted in 34 patients with a chair-side CAD/CAM technique. One crown per patient was randomly selected for evaluation at baseline, 6, 12, 24, 36, 48, 60 and 72 months according to the modified US Public Health Service criteria...
November 28, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27890357/effect-of-cement-space-on-stress-distribution-in-y-tzp-based-crowns
#16
Carlos Eduardo Edwards Rezende, Ana Flávia Sanches Borges, Carla Castiglia Gonzaga, Yuanyuan Duan, José Henrique Rubo, Jason Alan Griggs
OBJECTIVE: To evaluate the stress distribution in bi-layered Y-TZP based crowns, according to the occlusal internal spacing between coping and abutment. METHODS: Twelve premolar shaped Y-TZP copings were made by a CAD/CAM system and seated on an abutment to evaluate the internal fit at the occlusal third using micro-CT images. Considering the fitting range obtained experimentally, two 3D finite element models, consisting on bone tissue, a titanium implant, a zirconia abutment, cement layer and a bi-layered Y-TZP ceramic crown were constructed based on the micro-CT images, one corresponding to the thinnest cement space and other representing the specimen with the thickest cement space obtained experimentally...
November 24, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27890354/chairside-cad-cam-materials-part-1-measurement-of-elastic-constants-and-microstructural-characterization
#17
Renan Belli, Michael Wendler, Dominique de Ligny, Maria Rita Cicconi, Anselm Petschelt, Herwig Peterlik, Ulrich Lohbauer
OBJECTIVE: A deeper understanding of the mechanical behavior of dental restorative materials requires an insight into the materials elastic constants and microstructure. Here we aim to use complementary methodologies to thoroughly characterize chairside CAD/CAM materials and discuss the benefits and limitations of different analytical strategies. METHODS: Eight commercial CAM/CAM materials, ranging from polycrystalline zirconia (e.max ZirCAD, Ivoclar-Vivadent), reinforced glasses (Vitablocs Mark II, VITA; Empress CAD, Ivoclar-Vivadent) and glass-ceramics (e...
November 24, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27889825/a-critical-review-of-complementary-and-alternative-medicine-use-among-people-with-arthritis-a-focus-upon-prevalence-cost-user-profiles-motivation-decision-making-perceived-benefits-and-communication
#18
REVIEW
Lu Yang, David Sibbritt, Jon Adams
A critical review of complementary and alternative medicine (CAM) use among people with arthritis was conducted focusing upon prevalence and profile of CAM users as well as their motivation, decision-making, perceived benefits and communication with healthcare providers. A comprehensive search of peer-reviewed literature published from 2008 to 2015 was undertaken via CINAHL, Medline and AMED databases. The initial search identified 4331 articles, of which 49 articles met selection criteria. The review shows a high prevalence of CAM use (often multiple types and concurrent to conventional medical care) among those with arthritis which is not restricted to any particular geographic or social-economic status...
November 26, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27888323/the-calmodulin-gene-in-neurospora-crassa-is-required-for-normal-vegetative-growth-ultraviolet-survival-and-sexual-development
#19
Vijya Laxmi, Ranjan Tamuli
We isolated a Neurospora crassa mutant of the calmodulin (cmd) gene using repeat-induced point mutation and studied its phenotypes. The cmd (RIP) mutant showed a defect in growth, reduced aerial hyphae, decreased carotenoid accumulation, a severe reduction in viability upon ultraviolet (UV) irradiation, and a fertility defect. Moreover, meiotic silencing of the cmd gene resulted in a barren phenotype. In addition, we also performed site-directed mutational analysis of the calcium/calmodulin-dependent kinase-2 (Ca(2+)/CaMK-2), a target of the CaM protein encoded by the cmd gene...
November 25, 2016: Archives of Microbiology
https://www.readbyqxmd.com/read/27887929/anti-vascular-inflammatory-effects-of-pentacyclic-triterpenoids-from-astilbe-rivularis-in-vitro-and-in-vivo
#20
Hyejin Kang, Sae-Kwang Ku, Jongdoo Kim, Jiwoo Chung, Sang Chan Kim, Wei Zhou, MinKyun Na, Jong-Sup Bae
Sepsis is a systemic inflammatory condition resulting from bacterial infections. It is associated with high mortality rates, and its therapeutic options are limited. Transforming growth factor β induced protein (TGFBIp) is an extracellular matrix protein that functions as a mediator of experimental sepsis. C-27-carboxylated pentacyclic triterpenoids are specifically found in species of the genus Astilbe, and show several biological effects. Given the anti-inflammatory effects of pentacyclic triterpenoids, we investigated the effects of 3β-trans-p-coumaroyloxy-olean-12-en-27-oic acid (1) and 6β-hydroxy-3-oxoolean-12-en-27-oic acid (2) on TGFBIp-mediated vascular inflammatory responses...
November 22, 2016: Chemico-biological Interactions
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