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https://www.readbyqxmd.com/read/29471303/awareness-of-the-new-kidney-allocation-system-among-united-states-dialysis-providers-with-low-waitlisting
#1
Rachel E Patzer, Mohua Basu, Kayla D Smith, Laura Plantinga, Sumit Mohan, Cam Escoffery, Joyce J Kim, Taylor Melanson, Stephen O Pastan
It is unknown whether dialysis facility staff are aware of the new kidney allocation system implemented in December 2014, which changed how deceased donor kidneys are allocated and waiting time is calculated. U.S. dialysis facilities with low annual waitlisting (<15.2%) were surveyed as part of a large randomized study. Among 653 facilities, 57.9% of staff were aware of the policy change, with medical directors (84.4%) being more aware than social workers (73.3%), facility administrators (53.1%), nurse managers (46...
February 22, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29471140/activation-of-endothelial-trkb-receptors-induces-relaxation-of-resistance-arteries
#2
P Totoson, M Pedard, C Marie, C Demougeot
While brain-derived neurotrophic factor (BDNF) was previously reported to induce relaxation of conduit artery, whether the BDNF/TrkB (tropomyosin-related kinase) pathway is involved in the tone control of resistance arteries is not known. This study investigated TrkB receptors levels/localization and the vasomotor effect of the TrkB receptor agonist LM22A-4 in isolated third-order mesenteric arteries from rats. Immunostaining revealed the presence of both full-length and truncated TrkB receptors, especially at the endothelial level...
February 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29468890/a-systematic-review-of-the-traits-and-cognitions-associated-with-use-of-and-belief-in-complementary-and-alternative-medicine-cam
#3
Niall Galbraith, Tim Moss, Victoria Galbraith, Satvinder Purewal
Complementary and alternative medicine (CAM) use is widespread despite the controversy over its effectiveness. Although previous reviews have examined the demographics and attitudes of CAM users, there is no existing review on the traits or cognitions which characterise either CAM users or those who believe in CAM effectiveness. The current systematic review set out to address these gaps in the literature by applying a narrative synthesis. A bibliographic search and manual searches were undertaken and key authors were contacted...
February 22, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29468600/cad-cam-produces-dentures-with-improved-fit
#4
Otto Steinmassl, Herbert Dumfahrt, Ingrid Grunert, Patricia-Anca Steinmassl
OBJECTIVES: Resin polymerisation shrinkage reduces the congruence of the denture base with denture-bearing tissues and thereby decreases the retention of conventionally fabricated dentures. CAD/CAM denture manufacturing is a subtractive process, and polymerisation shrinkage is not an issue anymore. Therefore, CAD/CAM dentures are assumed to show a higher denture base congruence than conventionally fabricated dentures. It has been the aim of this study to test this hypothesis. MATERIALS AND METHODS: CAD/CAM dentures provided by four different manufacturers (AvaDent, Merz Dental, Whole You, Wieland/Ivoclar) were generated from ten different master casts...
February 22, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29467422/luminescent-and-paramagnetic-properties-of-nanoparticles-shed-light-on-their-interactions-with-proteins
#5
Giuditta Dal Cortivo, Gabriel E Wagner, Paolo Cortelletti, Krishna Mohan Padmanabha Das, Klaus Zangger, Adolfo Speghini, Daniele Dell'Orco, N Helge Meyer
Nanoparticles have been recognized as promising tools for targeted drug-delivery and protein therapeutics. However, the mechanisms of protein-nanoparticle interaction and the dynamics underlying the binding process are poorly understood. Here, we present a general methodology for the characterization of protein-nanoparticle interaction on a molecular level. To this end we combined biophysical techniques including nuclear magnetic resonance (NMR), circular dichroism (CD), resonance energy transfer (RET) and surface plasmon resonance (SPR)...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467379/fluvirucin-b6-a-new-macrolactam-isolated-from-a-marine-derived-actinomycete-of-the-genus-nocardiopsis
#6
Alain S Leutou, Inho Yang, Tu Cam Le, Dongyup Hahn, Kyung-Min Lim, Sang-Jip Nam, William Fenical
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
February 21, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29464146/virtual-surgical-planning-the-pearls-and-pitfalls
#7
Johnny I Efanov, Andrée-Anne Roy, Ke N Huang, Daniel E Borsuk
Objective: Over the past few years, virtual surgical planning (VSP) has evolved into a useful tool for the craniofacial surgeon. Virtual planning and computer-aided design and manufacturing (CAD/CAM) may assist in orthognathic, cranio-orbital, traumatic, and microsurgery of the craniofacial skeleton. Despite its increasing popularity, little emphasis has been placed on the learning curve. Methods: A retrospective analysis of consecutive virtual surgeries was done from July 2012 to October 2016 at the University of Montreal Teaching Hospitals...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29463791/the-interactome-and-spatial-redistribution-feature-of-ca-2-receptor-protein-calmodulin-reveals-a-novel-role-in-invadopodia-mediated-invasion
#8
Tao Li, Li Yi, Long Hai, Haiwen Ma, Zhennan Tao, Chen Zhang, Iruni Roshanie Abeysekera, Kai Zhao, Yihan Yang, Wei Wang, Bo Liu, Shengping Yu, Luqing Tong, Peidong Liu, Meng Zhu, Bingcheng Ren, Yu Lin, Kai Zhang, Cheng Cheng, Yubao Huang, Xuejun Yang
Numerous studies have shown that calmodulin (CaM) is a major regulator of calcium-dependent signaling, which regulates cell proliferation, programmed cell death, and autophagy in cancer. However, limited information is available on mechanisms underlying the effect of CaM on the invasive property of glioblastoma multiforme (GBM) cells, especially with respect to invadopodia formation. In this study, we find that CaM serves as a prognostic factor for GBM, and it is strongly associated with the invasive nature of this tumor...
February 20, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29463707/robo-and-ror-function-in-a-common-receptor-complex-to-regulate-wnt-mediated-neurite-outgrowth-in-caenorhabditis-elegans
#9
Jiaming Wang, Mei Ding
Growing axons are exposed to various guidance cues en route to their targets, but the mechanisms that govern the response of growth cones to combinations of signals remain largely elusive. Here, we found that the sole Robo receptor, SAX-3, in Caenorhabditis elegans functions as a coreceptor for Wnt/CWN-2 molecules. SAX-3 binds to Wnt/CWN-2 and facilitates the membrane recruitment of CWN-2. SAX-3 forms a complex with the Ror/CAM-1 receptor and its downstream effector Dsh/DSH-1, promoting signal transduction from Wnt to Dsh...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29463698/structural-basis-and-energy-landscape-for-the-ca-2-gating-and-calmodulation-of-the-kv7-2-k-channel
#10
Ganeko Bernardo-Seisdedos, Eider Nuñez, Carolina Gomis, Covadonga Malo, Álvaro Villarroel, Oscar Millet
The Kv7.2 (KCNQ2) channel is the principal molecular component of the slow voltage-gated, noninactivating K+ M-current, a key controller of neuronal excitability. To investigate the calmodulin (CaM)-mediated Ca2+ gating of the channel, we used NMR spectroscopy to structurally and dynamically describe the association of helices h A and h B of Kv7.2 with CaM, as a function of Ca2+ concentration. The structures of the CaM/Kv7.2-hAB complex at two different calcification states are reported here. In the presence of a basal cytosolic Ca2+ concentration (10-100 nM), only the N-lobe of CaM is Ca2+ -loaded and the complex (representative of the open channel) exhibits collective dynamics on the millisecond time scale toward a low-populated excited state (1...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29463360/severe-arthritic-changes-following-acetabular-labral-repair-and-femoroplasty-in-an-air-force-pilot
#11
Christopher J Sardon, Mathew L Resnick
BACKGROUND: Acetabular labral tears in the hip have become an increasingly common finding in active duty members due to improved diagnostic capabilities. This has led to a dramatic increase in operative management despite a lack of evidence to support clear long-term benefits. Literature review demonstrated overwhelmingly positive short-term outcomes for labral repairs; however, scattered case reports exist demonstrating debilitating outcomes in young patients, ultimately resulting in total hip arthroplasty...
February 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29462338/nh4-intensifies-cam-photosynthesis-and-counteracts-drought-effects-in-guzmania-monostachia-by-increasing-malate-transport-and-antioxidant-capacity
#12
Paula Natália Pereira, Marília Gaspar, J Andrew C Smith, Helenice Mercier
Guzmania monostachia (Bromeliaceae) is a tropical epiphyte capable of upregulating crassulacean acid metabolism (CAM) in its photosynthetic tissues in response to changing nutrient and water availability. Previous studies have shown that under drought there is a gradient of increasing CAM expression from the basal (youngest) to apical (oldest) portion of the leaves, and additionally that nitrogen deficiency can further increase CAM intensity in the leaf apex of this bromeliad. The present study investigated the interrelationships between nitrogen source (nitrate and/or ammonium) and water deficit in regulating CAM expression in G...
February 15, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29462238/secretsanta-flexible-pipelines-for-functional-secretome-prediction
#13
Anna Gogleva, Hajk-Georg Drost, Sebastian Schornack
Motivation: The secretome denotes the collection of secreted proteins exported outside of the cell. The functional roles of secreted proteins include the maintenance and remodelling of the extracellular matrix as well as signalling between host and non-host cells. These features make secretomes rich reservoirs of biomarkers for disease classification and host-pathogen interaction studies. Common biomarkers are extracellular proteins secreted via classical pathways that can be predicted from sequence by annotating the presence or absence of N-terminal signal peptides...
February 16, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29461223/non-removable-denture-prototypes-effective-in-dental-implantation
#14
R Orjonikidze, Z Orjonikidze, I Shirokov, S Arutyunov
Temporary prosthesis transformed into a prosthetic prototypes and manufactured by CAD/CAM technologies (computer copy milling) are used to specify the final form of future permanent restoration and to correct occlusal relationships, vertical size of non-removable dentures, and their occlusal surfaces. A progressive loading on bone tissue in the implantation area and soft tissues formation, have been assessed. In this regard, the choice and placement of temporary mini-implants, as the supports for non-removable denture prototypes for the period of osseointegration of two-stage intraosseous dental implants, are the issues of great importance...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29461138/enablers-and-barriers-to-the-development-of-interprofessional-collaboration-between-physicians-and-osteopaths-a-mixed-methods-study
#15
Chantal Morin, Johanne Desrosiers, Isabelle Gaboury
Osteopathy is a complementary and alternative medicine (CAM) that is growing in popularity. Increasing numbers of parents are seeking pediatric osteopathic care in addition to conventional medical care. Information about the development of interprofessional collaboration (IPC) between these practitioners is scarce. This explanatory sequential mixed methods study aimed to explore enablers of and barriers to the development of IPC between physicians and osteopaths involved with pediatric patients in primary care in Quebec, Canada...
February 20, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29458916/use-of-complementary-and-alternative-medicine-in-patients-with-multiple-sclerosis-in-germany
#16
Mario Gotta, Christoph A Mayer, Jutta Huebner
BACKGROUND: The use of complementary and alternative medicine (CAM) for chronic diseases such as multiple sclerosis (MS) is becoming an increasingly important issue for those affected. Especially in Germany there are only a few studies dealing with CAM, as yet. The aim of this study was to assess the prevalence, the methods used, the subjective benefits as well as physician/patient communication. METHODS: A structured questionnaire including demographic and disease-specific data, CAM use, perceived benefits as well as physician/patient communication was sent to real and web-based self-help groups for MS in Germany...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29457585/training-nurses-in-a-competency-framework-to-support-adults-with-epilepsy-and-intellectual-disability-the-epaid-cluster-rct
#17
Howard Ring, James Howlett, Mark Pennington, Christopher Smith, Marcus Redley, Caroline Murphy, Roxanne Hook, Adam Platt, Nakita Gilbert, Elizabeth Jones, Joanna Kelly, Angela Pullen, Adrian Mander, Cam Donaldson, Simon Rowe, James Wason, Fiona Irvine
BACKGROUND: People with an intellectual (learning) disability (ID) and epilepsy have an increased seizure frequency, higher frequencies of multiple antiepileptic drug (AED) use and side effects, higher treatment costs, higher mortality rates and more behavioural problems than the rest of the population with epilepsy. The introduction of nurse-led care may lead to improvements in outcome for those with an ID and epilepsy; however, this has not been tested in a definitive clinical trial...
February 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29457311/bicuspid-axial-wall-height-effect-on-cad-cam-crown-fracture-mode-on-preparations-containing-advanced-total-occlusal-convergence
#18
Matthew Miller, Nicholas DuVall, John Brewster, Michael N Wajdowicz, Ashley Harris, Howard W Roberts
PURPOSE: To evaluate bicuspid axial wall height effect on the fracture mode of adhesively luted, all-ceramic CAD/CAM crowns with a 20° total occlusal convergence (TOC). MATERIALS AND METHODS: Recently extracted premolars were randomly divided into 4 groups (n = 12) with all-ceramic crown preparations accomplished using a high-speed handpiece inserted into a milling device. Specimens were prepared containing occlusogingival axial wall heights of 3, 2, and 1 mm as well as a group containing a flat preparation surface with no axial wall height...
February 18, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29456682/l1cam-promotes-epithelial-to-mesenchymal-transition-and-formation-of-cancer-initiating-cells-in-human-endometrial-cancer
#19
Jinlong Chen, Fufeng Gao, Naifu Liu
Identification of novel factors critical for epithelial to mesenchymal transition (EMT) and cancer initiating cell (CIC) formation may aid in the identification of novel therapeutics for the treatment of endometrial cancer. The present study demonstrated that L1 cell adhesion molecule (CAM) is critical for EMT and formation of CICs in endometrial cancer. Overexpression of L1CAM may promote EMT with increased formation of CICs in HEC-1A endometrial cancer cells. CICs and mesenchymal status resist chemotherapeutic drugs and may regenerate the various cell types in tumors, thereby resulting in relapse of the disease...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456258/modifying-the-standard-disk-model-for-the-ultraviolet-spectral-analysis-of-disk-dominated-cataclysmic-variables-i-the-novalikes-mv-lyrae-bz-camelopardalis-and-v592-cassiopeiae
#20
Patrick Godon, Edward M Sion, Şölen Balman, William P Blair
The standard disk is often inadequate to model disk-dominated cataclysmic variables (CVs) and generates a spectrum that is bluer than the observed UV spectra. X-ray observations of these systems reveal an optically thin boundary layer (BL) expected to appear as an inner hole in the disk. Consequently, we truncate the inner disk. However, instead of removing the inner disk, we impose the no-shear boundary condition at the truncation radius, thereby lowering the disk temperature and generating a spectrum that better fits the UV data...
September 1, 2017: Astrophysical Journal
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