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https://www.readbyqxmd.com/read/28532114/hypocrellin-b-and-nano-silver-loaded-polymeric-nanoparticles-enhanced-generation-of-singlet-oxygen-for-improved-photodynamic-therapy
#1
Subramanian Natesan, Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Madi Madiyalakan, Thomas Woo, Rajaguru Palanisamy
A nanoparticulate photodynamic approach was employed with an objective to achieve enhanced production of singlet oxygen ((1)O2), for the management of posterior segment eye diseases like age related macular degeneration. The hypocrellin B (HB) loaded poly lactide-co-glycolide nanoparticle formulations were incorporated with nano silver (HBS-NPs). The optimized HBS-NPs contained 2.60±0.06mg/mL of HB and showed (i) 135.6 to 828.2nm size range, and (ii) negative zeta potential with a narrow polydispersity index...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530281/metallocorroles-as-inherently-chiral-chromophores-resolution-and-electronic-circular-dichroism-spectroscopy-of-a-tungsten-biscorrole
#2
Christine Schies, Abraham B Alemayehu, Hugo Vazquez-Lima, Kolle E Thomas, Torsten Bruhn, Gerhard Bringmann, Abhik Ghosh
An inherently chiral metallocorrole has been resolved for the first time by means of HPLC on a chiral stationary phase. For the compound in question, a homoleptic tungsten biscorrole, the absolute configurations of the enantiomers were assigned using online HPLC-ECD measurements in conjunction with time-dependent CAM-B3LYP calculations, which provided accurate simulations of the ECD spectra.
May 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28529661/slipped-capital-femoral-epiphysis-management-and-the-arthroscope
#3
F Accadbled, O May, C Thévenin-Lemoine, J Sales de Gauzy
BACKGROUND: In situ pinning of slipped capital femoral epiphysis (SCFE) results in various degrees of deformity of the femoral head-neck junction. Repetitive trauma from cam-type femoroacetabular impingement (FAI) can lead to labral tears and injury to the articular cartilage causing loss of function. Arthroscopic osteoplasty is an alternative to open procedure and to Southwick/Imhäuser-type osteotomies in symptomatic selected cases. SURGICAL TECHNIQUE: The amount of bone to be resected has to be carefully planned pre-operatively...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28527193/comparison-of-digital-intraoral-scanners-by-single-image-capture-system-and-full-color-movie-system
#4
Meguru Yamamoto, Yu Kataoka, Atsufumi Manabe
BACKGROUND: The use of dental computer-aided design/computer-aided manufacturing (CAD/CAM) restoration is rapidly increasing. OBJECTIVE: This study was performed to evaluate the marginal and internal cement thickness and the adhesive gap of internal cavities comprising CAD/CAM materials using two digital impression acquisition methods and micro-computed tomography. METHODS: Images obtained by a single-image acquisition system (Bluecam Ver...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28527036/osteogenesis-ability-of-cad-cam-porous-zirconia-scaffolds-enriched-with-nano-hydroxyapatite-particles
#5
Moustafa N Aboushelib, Rehab Shawky
BACKGROUND: The aim of this study was to evaluate osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with hydroxy apatite used to augment large boney defects in a dog model. METHODS: Surgical defects were made bilaterally on the lower jaw of 12 Beagle dogs. Cone beam CT images were used to create three dimensional images of the healed defects. Porous zirconia scaffolds were fabricated by milling custom made CAD/CAM blocks into the desired shape. After sintering, the pores of half of the scaffolds were filled with a nano-hydroxy apatite (HA) powder while the other half served as control...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28526939/awareness-of-cancer-signs-and-barriers-to-help-seeking-a-national-survey
#6
Mohammad Al Qadire
About 27% of cancer patients in Jordan are discovered in advanced stages; this resulted in poor prognosis and survival rates. One possible cause of late presentation is lack of awareness of warning signs and risk factors of cancer. The purpose of this study is to identify the level of awareness of cancer warning signs, risk factors, and barriers to seeking medical advice among the Jordanian public. A cross-sectional survey design was used. A convenience sample of 2292 participants from the Jordanian public was included in the study...
May 19, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28526443/mechanical-properties-of-polymer-infiltrated-ceramic-sodium-aluminum-silicate-composites-for-dental-restoration
#7
Bencang Cui, Jing Li, Huining Wang, Yuanhua Lin, Yang Shen, Ming Li, Xuliang Deng, Cewen Nan
OBJECTIVE: To fabricate indirect restorative composites for CAD/CAM applications and evaluate the mechanical properties. METHODS: Polymer-infiltrated-ceramic composites were prepared through infiltrating polymer into partially sintered sodium aluminum silicate ceramic blocks and curing. The corresponding samples were fabricated according to standard ISO-4049 using for mechanical properties measurement. The flexural strength and fracture toughness were measured using a mechanical property testing machine...
May 16, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28526429/use-of-a-cad-cam-poly-methyl-methacrylate-interim-prosthesis-for-direct-intraoral-splinting
#8
Periklis Proussaefs
This article describes a technique where an interim computer-aided design and computer-aided manufacturing (CAD-CAM) prosthesis is milled from a poly(methyl methacrylate) blank to confirm esthetics, occlusion, function, phonetics, and accessibility for oral hygiene. The interim prosthesis is then sectioned and reconnected intraorally with autopolymerizing acrylic resin. This interim prosthesis is used to fabricate the definitive stone cast. The interim prosthesis is then scanned with a laboratory scanner. By applying this technique, the implant positioning can be related to the occlusal plane, the contours of the teeth, and the flange...
May 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28526079/patient-needs-and-preferences-for-herb-drug-disease-interaction-alerts-a-structured-interview-study
#9
Carrie M Christensen, Rebecca S Morris, Seraphine Chepkemoi Kapsandoy, Melissa Archer, Jinqiu Kuang, Laura Shane-McWhorter, Bruce E Bray, Qing Zeng-Treitler
BACKGROUND: While complementary and alternative medicine (CAM) is commonly used in the United States and elsewhere, and hazardous interactions with prescription drugs can occur, patients do not regularly communicate with physicians about their CAM use. The objective of this study was to discover patient information needs and preferences for herb-drug-disease interaction alerts. METHODS: We recruited 50 people from several locations within the University of Utah Hospital to participate in this structured interview study...
May 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28525590/sdm-a-server-for-predicting-effects-of-mutations-on-protein-stability
#10
Arun Prasad Pandurangan, Bernardo Ochoa-Montaño, David B Ascher, Tom L Blundell
Here, we report a webserver for the improved SDM, used for predicting the effects of mutations on protein stability. As a pioneering knowledge-based approach, SDM has been highlighted as the most appropriate method to use in combination with many other approaches. We have updated the environment-specific amino-acid substitution tables based on the current expanded PDB (a 5-fold increase in information), and introduced new residue-conformation and interaction parameters, including packing density and residue depth...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28524619/use-of-complementary-and-alternative-medicines-is-associated-with-delay-to-initiation-of-disease-modifying-anti-rheumatic-drug-therapy-in-early-inflammatory-arthritis
#11
Manjari Lahiri, Amelia Santosa, Lay Kheng Teoh, Jane A Clayton, Sheen Yee Lim, Gim Gee Teng, Peter P M Cheung
OBJECTIVES: To study the predictors of complementary and alternative medicine (CAM) use in patients with early inflammatory arthritis (EIA), and its impact on delay to initiation of disease-modifying anti-rheumatic drugs (DMARD). METHODS: Data were collected prospectively from EIA patients aged ≥ 21 years. Current or prior CAM use was ascertained by face-to-face interview. Predictors of CAM use and its effect on time to DMARD initiation were determined by multivariate logistic regression and Cox proportional hazards, respectively...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28516798/complementary-and-alternative-medicine-use-in-uninsured-children-in-texas
#12
Sanghamitra M Misra, Danielle Guffey, Isabel Roth, Angelo P Giardino
Use of complementary and alternative medicine (CAM) among US children is 12% according to the 2012 National Health Interview Study. Certain pediatric populations have higher CAM use. We studied an uninsured population because limited access to care likely results in higher CAM use. We surveyed 250 uninsured patients in a free pediatric mobile clinic program. In the largely Hispanic population, rate of CAM use in the preceding 12 months was 45% among children and 59% among parents. Ninety-one percent of children who used CAM had parents who used CAM while only 32% of parents used CAM for themselves but did not use CAM for their children ( P < ...
May 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28516350/evaluation-of-vascular-effect-of-arsenic-using-in-vivo-assays
#13
Bharat Patel, Rajat Das, Anil Gautam, Mugdha Tiwari, Sukhdev Acharya, Sunil Kumar
Arsenic (As) is an abundant toxicant present in groundwater and soil in various parts of the world including eastern part of India. The epidemiological studies have shown that arsenic exposure is linked to developmental defects and miscarriage. Placenta is known to utilize vasculogenesis to develop its vasculature circulation. The effects of four different doses of sodium meta-arsenite (0, 10, 20, 75, and 150 ppm) were assessed on the vascular structure using two different in vivo models, i.e., Matrigel and chorioallantoic membrane (CAM) assay...
May 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28516199/cloning-and-stress-induced-expression-analysis-of-calmodulin-in-the-antarctic-alga-chlamydomonas-sp-ice-l
#14
Ying-Ying He, Yi-Bin Wang, Zhou Zheng, Fang-Ming Liu, Mei-Ling An, Xiao-Dong He, Chang-Feng Qu, Lu-Lu Li, Jin-Lai Miao
Calmodulin (CaM) is a Ca(2+)-binding protein that plays a role in several Ca(2+) signaling pathways, which dynamically regulates the activities of hundreds of proteins. The ice alga Chlamydomonas sp. ICE-L, which has the ability to adapt to extreme polar conditions, is a crucial primary producer in Antarctic ecosystem. This study hypothesized that Cam helps the ICE-L to adapt to the fluctuating conditions in the polar environment. It first verified the overall length of Cam, through RT-PCR and RACE-PCR, based on partial Cam transcriptome library of ICE-L...
May 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28515871/wolf-in-sheep-s-clothing-model-misspecification-undermines-tests-of-the-neutral-theory-for-life-histories
#15
Matthieu Authier, Lise M Aubry, Emmanuelle Cam
Understanding the processes behind change in reproductive state along life-history trajectories is a salient research program in evolutionary ecology. Two processes, state dependence and heterogeneity, can drive the dynamics of change among states. Both processes can operate simultaneously, begging the difficult question of how to tease them apart in practice. The Neutral Theory for Life Histories (NTLH) holds that the bulk of variations in life-history trajectories is due to state dependence and is hence neutral: Once previous (breeding) state is taken into account, variations are mostly random...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28515212/regulation-of-wnt-signaling-at-the-neuromuscular-junction-by-the-immunoglobulin-super-family-protein-rig-3-in-caenorhabditis-elegans
#16
Pratima Pandey, Ashwani Bhardwaj, Kavita Babu
Perturbations in synaptic function could affect the normal behavior of an animal, making it important to understand the regulatory mechanisms of synaptic signaling. Previous work has shown that in Caenorhabditis elegans an immunoglobulin super-family protein, RIG-3, functions in pre-synaptic neurons to maintain normal acetylcholine receptor levels at the neuromuscular junction (NMJ). In this study we elucidate the molecular and functional mechanism of RIG-3. We demonstrate by genetic and BiFC (Bi-molecular Fluorescence Complementation) assays that pre-synaptic RIG-3 functions by directly interacting with the immunoglobulin domain of the non-conventional Wnt receptor, ROR receptor tyrosine kinase (RTK), CAM-1, that functions in post-synaptic body-wall muscles...
May 17, 2017: Genetics
https://www.readbyqxmd.com/read/28514349/-elastic-properties-and-porosity-of-dental-blocks-made-from-non-metal-materials-used-for-chairside-cad-cam-crowns
#17
K E Goryainova, E S Morokov, M V Retinskaya, I J Lebedenko
Elastic properties and internal structure of glass-ceramic, feldspatic ceramic, PMMA and hybrid blocks for chairside CAD/CAM dental crowns were assessed by pulsed acoustic microscopy. Elastic modulus of hybrid ceramic was 1.5 times inferior to feldspatic ceramic and glass-ceramic but almost 10 times higher than those of polymer samples. We found the presence of pores from a few to hundreds of microns in the bulk of inorganic materials samples, isolated point defects were revealed in polymer materials while in hybrid material defects were not found...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28514042/effect-of-crystallization-firing-on-marginal-gap-of-cad-cam-fabricated-lithium-disilicate-crowns
#18
Steven A Gold, Jack L Ferracane, Juliana da Costa
PURPOSE: To evaluate the marginal gaps of CAD/CAM (CEREC 3) produced crowns made from leucite-reinforced glass-ceramic (IPS Empress CAD) blocks (LG), and lithium-disilicate (IPS e.max CAD) blocks before (LD-B), and after (LD-A) crystallization firing. MATERIALS AND METHODS: A human molar tooth (#19) was mounted with adjacent teeth on a typodont and prepared for a full-coverage ceramic crown. The typodont was assembled in the mannequin head to simulate clinical conditions...
May 17, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28513371/letter
#19
R Holtby
There are many implications for patient dignity and confidentiality if staff wear body cams, but if interactions are recorded it could help prevent difficult situations from escalating.
May 17, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28513366/nurses-wearing-body-cams
#20
J Kissoon
This is inconceivable in mental health settings. Can you imagine an acutely unwell individual with paranoid and psychotic symptoms being seen by a nurse wearing a body cam? Not to mention issues around confidentiality.
May 17, 2017: Nursing Standard
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