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https://www.readbyqxmd.com/read/28214625/curcumin-functionalized-silk-biomaterials-for-anti-aging-utility
#1
Lei Yang, Zhaozhu Zheng, Cheng Qian, Jianbing Wu, Yawen Liu, Shaozhe Guo, Gang Li, Meng Liu, Xiaoqin Wang, David L Kaplan
Curcumin is a natural antioxidant that is isolated from turmeric (Curcuma longa) and exhibits strong free radical scavenging activity, thus functional for anti-aging. However, poor stability and low solubility of curcumin in aqueous conditions limit its biomedical applications. Previous studies have shown that the anti-oxidation activity of curcumin embedded in silk fibroin films could be well preserved, resulting in the promoted adipogenesis from human mesenchymal stem cells (hMSCs) cultured on the surface of the films...
February 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28213545/antifungal-bacteria-on-woodland-salamander-skin-exhibit-high-taxonomic-diversity-and-geographic-variability
#2
Carly R Muletz-Wolz, Graziella V DiRenzo, Stephanie A Yarwood, Evan H Campbell Grant, Robert C Fleischer, Karen R Lips
Diverse bacteria inhabit amphibian skin, some of which inhibit growth of the fungal pathogen, Batrachochytrium dendrobatidis (Bd). Yet, there has been no systematic survey of anti-Bd bacteria across localities, species and elevations. This is important given geographic and taxonomic variation in amphibian susceptibility to Bd. Our sites were within the Appalachian Mountains where previous sampling indicated low Bd prevalence. We determined the number and identity of anti-Bd bacteria on 61 Plethodon salamanders (37 P...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28212817/in-vivo-toxicity-of-copper-oxide-lead-oxide-and-zinc-oxide-nanoparticles-acting-in-different-combinations-and-its-attenuation-with-a-complex-of-innocuous-bio-protectors
#3
Ilzira A Minigalieva, Boris A Katsnelson, Vladimir G Panov, Larisa I Privalova, Anatoly N Varaksin, Vladimir B Gurvich, Marina P Sutunkova, Vladimir Ya Shur, Ekaterina V Shishkina, Irene E Valamina, Ilya V Zubarev, Oleg H Makeyev, Ekaterina Y Meshtcheryakova, Svetlana V Klinova
Stable suspensions of metal oxide nanoparticles (Me-NPs) obtained by laser ablation of 99.99% pure copper, zinc or lead under a layer of deionized water were used separately, in three binary combinations and a triple combination in two independent experiments on rats. In one of the experiments the rats were instilled with Me-NPs intratracheally (i.t.) (for performing a broncho-alveolar lavage in 24hrs to estimate the cytological and biochemical indices of the response of the lower airways), while in the other, Me-NPs were repeatedly injected intraperitoneally (i...
February 14, 2017: Toxicology
https://www.readbyqxmd.com/read/28212500/cyto-genotoxic-and-dna-methylation-changes-induced-by-different-crystal-phases-of-tio2-np-in-bronchial-epithelial-16-hbe-cells
#4
Manosij Ghosh, Deniz Öner, Radu-Corneliu Duca, Stevan M Cokic, Sven Seys, Stef Kerkhofs, Kirsten Van Landuyt, Peter Hoet, Lode Godderis
With the increase in use of TiO2-np, a better understanding of their safety is important. In the present study the effect of different crystal phases of TiO2-np (anatase, rutile and anatase: rutile mixture; 20-26nm) were studied for cyto-genotoxicity and global DNA methylation and hydroxymethylation. Cytotoxic response was observed at a concentration of 25μg/ml for the particles tested. Results of comet and micronucleus (with and without CytB) assays revealed significant genotoxic effect of these particles...
February 10, 2017: Mutation Research
https://www.readbyqxmd.com/read/28212344/green-microwave-assisted-combustion-synthesis-of-zinc-oxide-nanoparticles-with-citrullus-colocynthis-l-schrad-characterization-and-biomedical-applications
#5
Susan Azizi, Rosfarizan Mohamad, Mahnaz Mahdavi Shahri
In this paper, a green microwave-assisted combustion approach to synthesize ZnO-NPs using zinc nitrate and Citrullus colocynthis (L.) Schrad (fruit, seed and pulp) extracts as bio-fuels is reported. The structure, optical, and colloidal properties of the synthesized ZnO-NP samples were studied. Results illustrate that the morphology and particle size of the ZnO samples are different and depend on the bio-fuel. The XRD results revealed that hexagonal wurtzite ZnO-NPs with mean particle size of 27-85 nm were produced by different bio-fuels...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211930/stable-amphiphilic-supramolecular-self-assembly-based-on-cyclodextrin-and-carborane-for-the-efficient-photodynamic-therapy
#6
Hejian Xiong, Dongfang Zhou, Xiaohua Zheng, Yanxin Qi, Yongheng Wang, Xiabin Jing, Yubin Huang
Novel and stable supramolecular nanoparticles (NP) were prepared based on the high affinity of carboranes to β-cyclodextrin for the efficient photodynamic therapy of porphyrin in vitro.
February 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28211497/the-inflammatory-cytokine-tnf-%C3%AE-promotes-the-premature-senescence-of-rat-nucleus-pulposus-cells-via-the-pi3k-akt-signaling-pathway
#7
Pei Li, Yibo Gan, Yuan Xu, Lei Song, Liyuan Wang, Bin Ouyang, Chengmin Zhang, Qiang Zhou
Premature senescence of nucleus pulposus (NP) cells and inflammation are two common features of degenerated discs. This study investigated the effects of the inflammatory cytokine TNF-α on the premature senescence of NP cells and the molecular mechanism behind this process. Rat NP cells were cultured with or without different concentrations of TNF-α for 1 and 3 days. The inhibitor LY294002 was used to determine the role of the PI3K/Akt pathway. NP cells that were incubated with TNF-α for 3 days followed by 3 days of recovery in the control medium were used to analyze cellular senescence...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211340/a-contribution-to-improve-the-calculation-of-the-acid-generating-potential-of-mining-wastes
#8
Aurélie Chopard, Mostafa Benzaazoua, Hassan Bouzahzah, Benoît Plante, Philippe Marion
Mine wastes from sulfide-bearing ore extraction and processing are often stored at the surface of mine sites and could generate mine drainage. Prediction tests are completed to predict the water quality associated with the deposition of mining wastes. Static tests can quickly assess the acid-generating potential (AP) and the neutralization potential (NP). Whereas some studies recommend to take into account a mineral reactivity factor for the NP determination, the reactivity rates of acidifying minerals are not considered in the AP calculation...
February 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28211275/suppression-of-hydrogen-evolution-by-oxygen-reduction-in-nanoporous-electrocatalysts
#9
Ellen Benn, Bernard Gaskey, Jonah D Erlebacher
Electroreduction of small molecules in aqueous solution often competes with the hydrogen evolution reaction (HER), especially if the reaction is driven even moderately hard using a large overpotential. Here, the oxygen reduction reaction (ORR) was studied under proton diffusion-limited conditions in slightly acidic electrolytes - a model system to study the relative transport kinetics of protons and reactants to an electrocatalyst and the relationship between transport and catalytic performance. Using dealloyed nanoporous nickel-platinum (np-NiPt) electrodes, we find the hydrogen evolution reaction can be completely suppressed even at high overpotentials (-400 mV vs...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28210893/analyzing-deadwood-volume-of-calabrian-pine-pinus-brutia-ten-in-relation-to-stand-and-site-parameters-a-case-study-in-k%C3%A3-pr%C3%A3-l%C3%A3-canyon-national-park
#10
Uzay Karahalil, Emin Z Başkent, Fatih Sivrikaya, Burak Kılıç
The importance of deadwood (DW) in forest ecosystems is widely recognized today. Deadwood is used as a proxy indicator for biodiversity conservation and sustainable management of forests. This research aims to determine the amount and spatial distribution of DW (standing dead trees, stumps, and coarse woody debris) and characterize the changes with few selected parameters in an unmanaged forest reserve of Köprülü Canyon National Park (NP). The data were collected from 387 temporary sample plots with different stand characteristics such as stand age, crown closure, site index, and density, and site parameters like elevation, aspect, slope, and distance to settlement areas of Calabrian pine (Pinus brutia Ten...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28210631/immunogenicity-and-cross-protection-in-mice-afforded-by-pandemic-h1n1-live-attenuated-influenza-vaccine-containing-wild-type-nucleoprotein
#11
Andrey Rekstin, Irina Isakova-Sivak, Galina Petukhova, Daniil Korenkov, Igor Losev, Tatiana Smolonogina, Tatiana Tretiak, Svetlana Donina, Svetlana Shcherbik, Tatiana Bousse, Larisa Rudenko
Since conserved viral proteins of influenza virus, such as nucleoprotein (NP) and matrix 1 protein, are the main targets for virus-specific CD8+ cytotoxic T-lymphocytes (CTLs), we hypothesized that introduction of the NP gene of wild-type virus into the genome of vaccine reassortants could lead to better immunogenicity and afford better protection. This paper describes in vitro and in vivo preclinical studies of two new reassortants of pandemic H1N1 live attenuated influenza vaccine (LAIV) candidates. One had the hemagglutinin (HA) and neuraminidase (NA) genes from A/South Africa/3626/2013 H1N1 wild-type virus on the A/Leningrad/134/17/57 master donor virus backbone (6 : 2 formulation) while the second had the HA, NA, and NP genes of the wild-type virus on the same backbone (5 : 3 formulation)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28210096/interactive-data-exploration-with-smart-drill-down
#12
Manas Joglekar, Hector Garcia-Molina, Aditya Parameswaran
We present smart drill-down, an operator for interactively exploring a relational table to discover and summarize "interesting" groups of tuples. Each group of tuples is described by a rule. For instance, the rule (a, b, ⋆, 1000) tells us that there are a thousand tuples with value a in the first column and b in the second column (and any value in the third column). Smart drill-down presents an analyst with a list of rules that together describe interesting aspects of the table. The analyst can tailor the definition of interesting, and can interactively apply smart drill-down on an existing rule to explore that part of the table...
May 2016: Proceedings
https://www.readbyqxmd.com/read/28209253/determination-of-low-level-np-237-by-various-techniques
#13
L Benedik, M Trdin
Determination of a low level (237)Np in environmental samples was performed by various techniques: i) a direct gamma-ray spectrometry, ii) an alpha-particle spectrometry that followed pre-separation of neptunium radioisotope(s) by ion-exchange or extraction chromatography and iii) pre-separation radiochemical neutron activation analysis. The methods used were applied to various reference materials with inorganic and organic matrix as well as to a wide range of neptunium content. The results were compared with reference and literature values...
February 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28209192/learning-from-2523-trauma-deaths-in-india-opportunities-to-prevent-in-hospital-deaths
#14
Nobhojit Roy, Deepa Kizhakke Veetil, Monty Uttam Khajanchi, Vineet Kumar, Harris Solomon, Jyoti Kamble, Debojit Basak, Göran Tomson, Johan von Schreeb
BACKGROUND: A systematic analysis of trauma deaths is a step towards trauma quality improvement in Indian hospitals. This study estimates the magnitude of preventable trauma deaths in five Indian hospitals, and uses a peer-review process to identify opportunities for improvement (OFI) in trauma care delivery. METHODS: All trauma deaths that occurred within 30 days of hospitalization in five urban university hospitals in India were retrospectively abstracted for demography, mechanism of injury, transfer status, injury description by clinical, investigation and operative findings...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28209027/silicon-nanostructures-produced-by-modified-macetch-method-for-antireflective-si-surface
#15
Stepan Nichkalo, Anatoly Druzhinin, Anatoliy Evtukh, Oleg Bratus', Olga Steblova
This work pertains to the method for modification of silicon (Si) wafer morphology by metal-assisted chemical etching (MacEtch) technique suitable for fabrication of antireflective Si surfaces. For this purpose, we made different Au catalyst patterns on the surface of Si substrate. This modification allowed to obtain the close-packed Au nanodrop (ND) pattern that generates the nanowires (NWs) and the well-separated Au NDs, which induce the nanopore (NP) formation. The antireflective properties of these structures in comparison with NWs produced by the conventional Ag-MacEtch method were analysed...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28208845/role-of-altered-venous-blood-lactate-and-hba1c-in-women-with-gestational-diabetes-mellitus
#16
C S Nagalakshmi, N U Santhosh, N Krishnamurthy, Chethana Chethan, M K Shilpashree
INTRODUCTION: Being a mirror image of metabolic syndrome, Gestational Diabetes Mellitus (GDM) is associated with significant maternal and fetal morbidity. Increased blood lactate concentration and alterations of substrate utilization are partly involved in development of insulin resistance in GDM. Fetuses born to such mothers have shown low umbilical vein oxygen saturation and low oxygen content and increased lactate concentrations. These changes may certainly reflect enhanced fetal metabolism as a result of hyperglycaemia and hyperinsulinemia and therefore, these fetuses deserve intense surveillance at term and during delivery...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208108/dietary-administration-of-edc-mixtures-a-focus-on-fish-lipid-metabolism
#17
O Carnevali, V Notarstefano, I Olivotto, M Graziano, P Gallo, I Di Marco Pisciottano, L Vaccari, A Mandich, E Giorgini, F Maradonna
Many man-made chemical compounds are recognized as endocrine disruptors and once released into the environment are likely to spread and bioaccumulate in wild species. Due to their lipophilic nature, these substances pass through the cell membrane or bind to specific receptors activating physiological responses that in the long run can cause reproductive impairment, physiological disorders, including the occurrence of metabolic syndromes. One significant source of contamination is represented by the consumption of polluted food...
February 6, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28208084/hypomethylation-of-tissue-factor-pathway-inhibitor-2-in-human-placenta-of-preeclampsia
#18
Xirong Xiao, Xiang Tao, Yongxiang Wang, Lisha Zhu, Yunzhen Ye, Haiyan Liu, Qiongjie Zhou, Xiaotian Li, Yu Xiong
OBJECTIVES: To investigate the expression, DNA methylation status and its regulatory mechanism of tissue factor pathway inhibitor 2 (TFPI-2) in human placenta tissues of preeclampsia (PE). MATERIAL AND METHODS: We studied the mRNA and protein expression and the promoter methylation levels of TFPI-2 in the PE placentas compared with those in the normal pregnant (NP) women. Quantitative real-time polymerase chain reaction, immunohistochemistry, western blot, and Sequenom MassARRAY were used for placenta tissue detection...
February 8, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28207788/self-complementary-adeno-associated-virus-serotype-6-mediated-knockdown-of-adamts4-induces-long-term-and-effective-enhancement-of-aggrecan-in-degenerative-human-nucleus-pulposus-cells-a-new-therapeutic-approach-for-intervertebral-disc-disorders
#19
Demissew Shenegelegn Mern, Anja Tschugg, Sebastian Hartmann, Claudius Thomé
Inhibition of intervertebral disc (IVD) degeneration, which is often accompanied by painful inflammatory and immunopathological processes, is challenging. Current IVD gene therapeutic approaches are based on adenoviral gene delivery systems, which are limited by immune reactions to their viral proteins. Their applications in IVDs near to sensitive neural structure could provoke toxicity and immunological side-effects with neurological deficits. Self-complementary adeno-associated virus (scAAV) vectors, which do not express any viral gene and are not linked with any known disease in humans, are attractive therapeutic gene delivery vectors in degenerative IVDs...
2017: PloS One
https://www.readbyqxmd.com/read/28207656/biomechanical-evaluation-of-transpedicular-nucleotomy-with-intact-annulus-fibrosus
#20
Fabrizio Russo, Robert A Hartman, Kevin M Bell, Nam Vo, Gwendolyn A Sowa, James D Kang, Gianluca Vadalà, Vincenzo Denaro
STUDY DESIGN: Biomechanical testing of partially nucleotomized ovine cadaveric spines. OBJECTIVE: To explore how the nucleus pulposus (NP) affects the biomechanical behavior of the intervertebral disc (IVD) by performing a partial nucleotomy via the transpedicular approach. SUMMARY OF BACKGROUND DATA: Mechanical loading represents a crucial part of IVD homeostasis. However, traditional regenerative strategies require violation of the annulus fibrosus (AF) resulting in significant alteration of joint mechanics...
February 15, 2017: Spine
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