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https://www.readbyqxmd.com/read/29786724/influence-of-a-nanoparticle-on-the-structure-and-dynamics-of-model-ionomer-melts
#1
Janani Sampath, Lisa M Hall
We simulate a single spherical nanoparticle (NP) surrounded by partially neutralized ionomers. The coarse-grained ionomers consist of a linear backbone of neutral monomer beads with charged pendant beads and counterions, along with pendant 'sticker' beads that represent unneutralized acid groups. Two different NP interactions are considered; one in which the NP interacts uniformly with all beads in the system (neutral NP) and another in which the NP has higher cohesive interactions with ions and stickers (sticky NP)...
May 22, 2018: Soft Matter
https://www.readbyqxmd.com/read/29786672/the-impacts-of-spatiotemporal-landscape-changes-on-water-quality-in-shenzhen-china
#2
Zhenhuan Liu, Haiyan Yang
The urban landscape in China has changed rapidly over the past four decades, which has led to various environmental consequences, such as water quality degradation at the regional scale. To improve water restoration strategies and policies, this study assessed the relationship between water quality and landscape change in Shenzhen, China, using panel regression analysis. The results show that decreases in natural and semi-natural landscape compositions have had significant negative effects on water quality...
May 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29784673/formation-of-the-sacrum-requires-down-regulation-of-sonic-hedgehog-signaling-in-the-sacral-intervertebral-discs
#3
Raffaella Bonavita, Kathleen Vincent, Robert Pinelli, Chitra Lekha Dahia
In humans, the sacrum forms an important component of the pelvic arch, and it transfers the weight of the body to the lower limbs. The sacrum is formed by collapse of the intervertebral discs (IVDs) between the five sacral vertebrae during childhood, and their fusion to form a single bone. We show that collapse of the sacral discs in the mouse is associated with the down-regulation of sonic hedgehog (SHH) signaling in the nucleus pulposus (NP) of the disc, and many aspects of this phenotype can be reversed by experimental postnatal activation of HH signaling...
May 21, 2018: Biology Open
https://www.readbyqxmd.com/read/29783874/influence-of-bovine-serum-albumin-pre-incubation-on-toxicity-and-er-stress-apoptosis-gene-expression-in-thp-1-macrophages-exposed-to-zno-nanoparticles
#4
Hongying Liang, Tong He, Jimin Long, Liangliang Liu, Guochao Liao, Yanhuai Ding, Yi Cao
When entering a biological environment, proteins could be adsorbed onto nanoparticles (NPs), which will consequently influence the toxicity of NPs. This study used bovine serum albumin (BSA) as the model for serum protein and investigated its interactions with three different types of ZnO NPs, coded as XFI06 (pristine NPs of 20 nm), NM110 (pristine NPs of 100 nm) and NM111 (hydrophobic NPs of 130 nm). Atomic force microscope indicated the adsorption of BSA to ZnO NPs, leading to the increase of NP diameters...
May 21, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29783089/self-stabilized-silk-sericin-based-nanoparticles-in-vivo-biocompatibility-and-reduced-doxorubicin-induced-toxicity
#5
Doudou Hu, Ting Li, Zongpu Xu, Di Liu, Mingying Yang, Liangjun Zhu
A variety of colloid stabilizers and cryoprotectants confer improved nanoparticle (NP) colloidal stability and redisperability. However, the discounted tumor targetability, delivery efficacy and possible side effects limit the application in the vascular delivery of NPs. Here we present the water-soluble silk sericin (SS) not only as a material for the preparation of NPs, but also both a dispersion stabilizer and a cryoprotectant. In the absence of any stabilizers, SS-based NPs (SSC@NPs) could resist to the serum protein adsorption, preventing the formation of particle agglomerates...
May 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29782682/a-centimeter-scale-inorganic-nanoparticle-superlattice-monolayer-with-non-close-packing-and-its-high-performance-in-memory-devices
#6
Ke Wang, Haifeng Ling, Yan Bao, Mengting Yang, Yi Yang, Mubashir Hussain, Huayang Wang, Lianbin Zhang, Linghai Xie, Mingdong Yi, Wei Huang, Xiaolin Xie, Jintao Zhu
Due to the near-field coupling effect, non-close-packed nanoparticle (NP) assemblies with tunable interparticle distance (d) attract great attention and show huge potential applications in various functional devices, e.g., organic nano-floating-gate memory (NFGM) devices. Unfortunately, the fabrication of device-scale non-close-packed 2D NPs material still remains a challenge, limiting its practical applications. Here, a facile yet robust "rapid liquid-liquid interface assembly" strategy is reported to generate a non-close-packed AuNP superlattice monolayer (SM) on a centimeter scale for high-performance pentacene-based NFGM...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782678/nanoparticle-enhanced-silver-nanowire-plasmonic-electrodes-for-high-performance-organic-optoelectronic-devices
#7
Taehyo Kim, Saewon Kang, Jungwoo Heo, Seungse Cho, Jae Won Kim, Ayoung Choe, Bright Walker, Ravi Shanker, Hyunhyub Ko, Jin Young Kim
Improved performance in plasmonic organic solar cells (OSCs) and organic light-emitting diodes (OLEDs) via strong plasmon-coupling effects generated by aligned silver nanowire (AgNW) transparent electrodes decorated with core-shell silver-silica nanoparticles (Ag@SiO2 NPs) is demonstrated. NP-enhanced plasmonic AgNW (Ag@SiO2 NP-AgNW) electrodes enable substantially enhanced radiative emission and light absorption efficiency due to strong hybridized plasmon coupling between localized surface plasmons (LSPs) and propagating surface plasmon polaritons (SPPs) modes, which leads to improved device performance in organic optoelectronic devices (OODs)...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782216/carbapenemase-producing-carbapenem-resistant-enterobacteriaceae-from-bangkok-thailand-and-their-detection-by-the-carba-np-and-modified-carbapenem-inactivation-method-tests
#8
Warawut Laolerd, Yukihiro Akeda, Likit Preeyanon, Panan Ratthawongjirakul, Pitak Santanirand
AIM: The purpose of the study was to determine the epidemiology of carbapenemase genes among carbapenem-resistant Enterobacteriaceae and evaluate the Carba NP and modified carbapenem inactivation method (mCIM) tests in their detection. MATERIALS AND METHODS: A total of 287 nonduplicated Enterobacteriaceae isolates, which were at least resistant to one of the carbapenems, were identified and detected for carbapenemase genes by multiplex PCR covering blaKPC , blaNDM , blaVIM , blaIMP , and blaOXA-48-like ...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29781885/improved-cognitive-performance-and-reduced-monocyte-activation-in-virally-suppressed-chronic-hiv-following-dual-ccr2-and-ccr5-antagonism
#9
Michelle L D'Antoni, Robert H Paul, Brooks I Mitchell, Lindsay Kohorn, Laurent Fischer, Eric Lefebvre, Star Seyedkazemi, Beau K Nakamoto, Maegen Walker, Kalpana J Kallianpur, Debra Ogata-Arakaki, Lishomwa C Ndhlovu, Cecilia Shikuma
OBJECTIVE: To evaluate changes in neuropsychological (NP) performance and in plasma and cell surface markers of peripheral monocyte activation/migration following treatment with cenicriviroc (CVC), a dual C-C chemokine receptor type 2 (CCR2) and type 5 (CCR5) antagonist, in treatment-experienced, HIV-infected individuals. SETTING: Single-arm, 24-week, open-label clinical trial. METHODS: HIV-infected individuals on antiretroviral therapy (ART) >1 year with plasma HIV RNA <50 copies/ml and below-normal cognitive performance [defined as age, gender and education-adjusted NP performance (NPZ) <-0...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781561/the-clinical-characteristics-and-histopathological-features-of-chronic-rhinosinusitis-with-unilateral-nasal-polyps-in-136-patients-in-southern-china
#10
Zhuo Chen, Yang Peng, Chew Lip Ng, Peng Jin, Jing Liu, Ying Ying Li, Yan Yan, Yan Hui Liu, Xin Lan Luo, Qian Hui Qiu, De Yun Wang
Based on the presence of nasal polyps (NP) on endoscopy, chronic rhinosinusitis (CRS) has been clinically divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). While the majority of cases are bilateral, NPs can present unilaterally. CRS with unilateral NP (UNP) is the most common presentation in unilateral polyposis, but there have been few studies on UNP. Lee et al have shown that UNP had more favorable objective surgical outcomes than bilateral disease. This article is protected by copyright...
May 21, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29780985/the-correlation-between-gelatin-macroscale-differences-and-nanoparticle-properties-providing-insight-into-biopolymer-variability
#11
André T Stevenson, Danny J Jankus, Max A Tarshis, Abby R Whittington
From therapeutic delivery to sustainable packaging, manipulation of biopolymers into nanostructures imparts biocompatibility to numerous materials with minimal environmental pollution during processing. While biopolymers are appealing natural based materials, the lack of nanoparticle (NP) physicochemical consistency has decreased their nanoscale translation into actual products. Insights regarding the macroscale and nanoscale property variation of gelatin, one of the most common biopolymers already utilized in its bulk form, are presented...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29780511/through-tissue-imaging-of-a-live-breast-cancer-tumour-model-using-handheld-surface-enhanced-spatially-offset-resonance-raman-spectroscopy-sesorrs
#12
Fay Nicolson, Lauren E Jamieson, Samuel Mabbott, Konstantinos Plakas, Neil C Shand, Michael R Detty, Duncan Graham, Karen Faulds
In order to improve patient survival and reduce the amount of unnecessary and traumatic biopsies, non-invasive detection of cancerous tumours is of imperative and urgent need. Multicellular tumour spheroids (MTS) can be used as an ex vivo cancer tumour model, to model in vivo nanoparticle (NP) uptake by the enhanced permeability and retention (EPR) effect. Surface enhanced spatially offset Raman spectroscopy (SESORS) combines both surface enhanced Raman spectroscopy (SERS) and spatially offset Raman spectroscopy (SORS) to yield enhanced Raman signals at much greater sub-surface levels...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780276/design-and-assembly-of-ternary-pt-re-sno-2-nps-by-controlling-the-zeta-potential-of-individual-pt-re-and-sno-2-nps
#13
Elżbieta Drzymała, Grzegorz Gruzeł, Anna Pajor-Świerzy, Joanna Depciuch, Robert Socha, Andrzej Kowal, Piotr Warszyński, Magdalena Parlinska-Wojtan
In this study Pt, Re, and SnO2 nanoparticles (NPs) were combined in a controlled manner into binary and ternary combinations for a possible application for ethanol oxidation. For this purpose, zeta potentials as a function of the pH of the individual NPs solutions were measured. In order to successfully combine the NPs into Pt/SnO2 and Re/SnO2 NPs, the solutions were mixed together at a pH guaranteeing opposite zeta potentials of the metal and oxide NPs. The individually synthesized NPs and their binary/ternary combinations were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning transmission electron microscopy (STEM) combined with energy dispersive X-ray spectroscopy (EDS) analysis...
2018: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/29780227/neurophysiologic-tests-screening-cognitive-impairment-in-idiopathic-intracranial-hypertension-patients
#14
Iman A Elbanhawy, Gihan M Ramzy, Mye A Basheer, Diana M Khedr
Background: Idiopathic intracranial hypertension (IIH) is a disorder with increased intracranial pressure of obscure cause. Patients with IIH may suffer from difficulty in thinking or concentrating. This work aimed at highlighting the neurophysiologic suggestions of cognitive impairment in IIH patients. Methods: Twenty patients with IIH-and a similar number of matched control subjects-were examined in this case-control study. The P300 and contingent negative variation (CNV) were performed...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29780126/a-case-of-intractable-hemophagocytic-syndrome-associated-with-systemic-lupus-erythematosus-resistant-to-corticosteroids-and-intravenous-cyclophosphamide-that-was-successfully-treated-with-cyclosporine-a
#15
Hirofumi Toko, Hiroto Tsuboi, Naoto Umeda, Fumika Honda, Ayako Ohyama, Hidenori Takahashi, Saori Abe, Masahiro Yokosawa, Hiromitsu Asashima, Shinya Hagiwara, Tomoya Hirota, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Hemophagocytic syndrome (HPS) associated with systemic lupus erythematosus (SLE), dubbed acute lupus hemophagocytic syndrome (ALHS), is an intractable complication of SLE. A 24-year-old man who had been diagnosed with SLE three months previously, presented with fever, rash, hallucination, and pancytopenia accompanied with hyperferritinemia and bone marrow hemophagocytosis. He was diagnosed with ALHS and neuropsychiatric (NP)-SLE. Although 4 courses of methylprednisolone pulse therapy and 1 course of intravenous cyclophosphamide (IVCY) improved his NP-SLE, his ALHS did not respond...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29779982/statistical-control-of-the-production-of-blood-components-by-control-charts-of-attribute-to-improve-quality-characteristics-and-to-comply-with-current-specifications
#16
REVIEW
Paulo Pereira, Jerard Seghatchian, Beatriz Caldeira, Sandra Xavier, Gracinda de Sousa
Statistical process control (SPC) is closely related to good quality control practices in the manufacturing process. One of the primary goals is to detect unnatural patterns, allowing the production service to control the conformity of the blood components produced. Despite being recommended by national and international standards, its exercise is not uniform, and sometimes the methodology used is misinterpreted as SPC. When the input data has a Gaussian distribution, control charts for variables are proposed...
May 8, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29779922/safety-tolerability-acceptability-and-immunogenicity-of-an-influenza-vaccine-delivered-to-human-skin-by-a-novel-high-density-microprojection-array-patch-nanopatch%C3%A2
#17
Germain J P Fernando, Julian Hickling, Cesar M Jayashi Flores, Paul Griffin, Christopher D Anderson, S Rachel Skinner, Cristyn Davies, Katey Witham, Melinda Pryor, Jesse Bodle, Steve Rockman, Ian H Frazer, Angus H Forster
BACKGROUND: Injection using needle and syringe (N&S) is the most widely used method for vaccination, but requires trained healthcare workers. Fear of needles, risk of needle-stick injury, and the need to reconstitute lyophilised vaccines, are also drawbacks. The Nanopatch (NP) is a microarray skin patch comprised of a high-density array of microprojections dry-coated with vaccine that is being developed to address these shortcomings. Here we report a randomised, partly-blinded, placebo-controlled trial that represents the first use in humans of the NP to deliver a vaccine...
May 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29779504/association-of-dietary-patterns-of-american-adults-with-bone-mineral-density-and-fracture
#18
Mohsen Mazidi, Andre Pascal Kengne, Hassan Vatanparast
OBJECTIVE: In a representative sample of US adults, we investigated the associations of nutrient patterns (NP) with bone mineral density (BMD) and fractures. DESIGN: Cross-sectional. SETTING: US community-based National Health and Nutrition Examination Survey (NHANES). SUBJECTS: Participants with measured data on dietary intake and BMD from 2005 to 2010 were included. Principal components analysis was used to identify NP...
May 21, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29778963/ph-dependent-silica-nanoparticle-dissolution-and-cargo-release
#19
Giorgia Giovaninni, Colin J Moore, Andrew J Hall, Hugh J Byrne, Vladimir Gubala
The dissolution of microporous silica nanoparticles (NP) in aqueous environments of different biologically relevant pH was studied in order to assess their potential as drug delivery vehicles. Silica NPs, loaded with fluorescein, were prepared using different organosilane precursors (tetraethoxysilane, ethyl triethoxysilane or a 1:1 molar ratio of both) and NP dissolution was evaluated in aqueous conditions at pH 4, pH 6 and pH 7.4. These conditions correspond to the acidity of the intracellular environment (late endosome, early endosome, cytosol respectively) and gastrointestinal tract ('fed' stomach, duodenum and jejunum respectively)...
May 16, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29778933/neurotoxic-impact-of-acute-tio-2-nanoparticle-exposure-on-a-benthic-marine-bivalve-mollusk-tegillarca-granosa
#20
Xiaofan Guan, Wei Shi, Shanjie Zha, Jiahuan Rong, Wenhao Su, Guangxu Liu
The release of nanoparticles (NPs) into the ocean inevitably poses a threat to marine organisms. However, to date, the neurotoxic effects of NPs remains poorly understood in marine bivalve species. Therefore, in order to gain a better understanding of the physiological effects of NPs, the impact of acute (96 h) TiO2 NP exposure on the in vivo concentrations of three major neurotransmitters, the activity of AChE, and the expression of neurotransmitter-related genes was investigated in the blood clam, Tegillarca granosa...
May 17, 2018: Aquatic Toxicology
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