Jingwen Chen, Rui Yang, Hongwei Yu, Hao Wu, Nan Wu, Suhe Wang, Xiaorui Yin, Xiangyang Shi, Han Wang
Ultrasmall iron oxide nanoparticles (USIO NPs) are expected to become the next generation T 1 contrast agents; however, their diagnostic and therapeutic potential for primary brain tumors (such as glioblastoma multiforme, GBM) is yet to be explored. At present, the main challenge is the effective hindering of biological barriers, including the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB). Herein, we aimed to investigate whether the USIO NPs, in combination with MR-guided focused ultrasound (MRgFUS), could intensify MR imaging of GBM...
April 22, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine