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https://www.readbyqxmd.com/read/28436418/oxoaporphine-metal-complexes-co-ii-ni-ii-zn-ii-with-high-antitumor-activity-by-inducing-mitochondria-mediated-apoptosis-and-s-phase-arrest-in-hepg2
#1
Jiao-Lan Qin, Wen-Ying Shen, Zhen-Feng Chen, Li-Fang Zhao, Qi-Pin Qin, Yan-Cheng Yu, Hong Liang
Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes 1-3 have been synthesized and fully characterized. 1-3 have similar mononuclear structures with the metal and ligand ratio of 1:2. 1-3 exhibited higher cytotoxicity than the OD ligand and cisplatin against HepG2, T-24, BEL-7404, MGC80-3 and SK-OV-3/DDP cells, with IC50 value of 0.23-4.31 μM. Interestingly, 0.5 μM 1-3 significantly caused HepG2 arrest at S-phase, which was associated with the up-regulation of p53, p21, p27, Chk1 and Chk2 proteins, and decrease in cyclin A, CDK2, Cdc25A, PCNA proteins...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435396/lentivirus-mediated-knockdown-of-p27rf-rho-inhibits-hepatocellular-carcinoma-cell-growth
#2
Shuli Xie, Guangyi Wang, Guofu Chen, Mingguang Zhu, Guoyue Lv
AIM OF THE STUDY: To investigate the effects of P27RF-Rho on hepatocellular carcinoma (HCC) cell growth and explore the possibility of using it as a novel therapeutic target for liver cancer treatment. MATERIAL AND METHODS: P27RF-Rho in HCC cells was silenced by lentivirus-mediated RNA interference, and the silencing effect was verified by RT-PCR. Cell proliferation was determined by MTT and clone formation assay. Cell cycle phase and apoptosis were detected through FACS...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28432871/mir-24-3p-is-overexpressed-in-hodgkin-lymphoma-and-protects-hodgkin-and-reed-sternberg-cells-from-apoptosis
#3
Ye Yuan, Joost Kluiver, Jasper Koerts, Debora de Jong, Bea Rutgers, Fazlyn Reeny Abdul Razak, Martijn Terpstra, Boudewijn Plaat, Ilja M Nolte, Arjan Diepstra, Lydia Visser, Klaas Kok, Anke van den Berg
miRNAs play important roles in biological processes, such as proliferation, metabolism, differentiation, and apoptosis, whereas altered expression levels contribute to diseases, such as cancers. We identified miRNAs with aberrant expression in Hodgkin lymphoma (HL) and investigated their role in pathogenesis. Small RNA sequencing revealed 84 significantly differentially expressed miRNAs in HL cell lines as compared to germinal center B cells. Three up-regulated miRNAs-miR-23a-3p, miR-24-3p, and miR-27a-3p-were derived from one primary miRNA transcript...
April 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28425505/novel-interactions-of-the-von-hippel-lindau-pvhl-tumor-suppressor-with-the-cdkn1-family-of-cell-cycle-inhibitors
#4
Giovanni Minervini, Raffaele Lopreiato, Raissa Bortolotto, Antonella Falconieri, Geppo Sartori, Silvio C E Tosatto
Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor predisposes patients to develop different highly vascularized cancers. pVHL targets the hypoxia-inducible transcription factor (HIF-1α) for degradation, modulating the activation of various genes involved in hypoxia response. Hypoxia plays a relevant role in regulating cell cycle progression, inducing growth arrest in cells exposed to prolonged oxygen deprivation. However, the exact molecular details driving this transition are far from understood...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425432/angiogenic-and-lymphangiogenic-profiles-in-histological-variants-of-papillary-thyroid-carcinoma
#5
Vesna Skuletic, Gordana D Radosavljevic, Jelena Pantic, Bojana Simovic Markovic, Ivan Jovanovic, Nikola Jankovic, Dusica Petrovic, Andra Jevtovic, Radan Dzodic, Nebojsa Arsenijevic
INTRODUCTION    Papillary thyroid carcinoma (PTC) is a well-differentiated tumor that occurs in several histological variants whose biological behaviors remain unclear. Angiogenesis and lymphangiogenesis are critical processes that enable tumor progression.  OBJECTIVES    The purpose of this study was to evaluate the angiogenic and lymphangiogenic phenotypes of PTC considering the differences between histological variants. PATIENTS AND METHODS    Angiogenic and lymphangiogenic profiles were analyzed by microvascular density (MVD) and lymphovascular density (LVD) determination in 73 cases of PTC using immunohistochemistry...
April 20, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28423657/identification-and-characterization-of-rassf1c-pirna-target-genes-in-lung-cancer-cells
#6
Mark E Reeves, Mathew Firek, Abdullaati Jliedi, Yousef G Amaar
RASSF1C up-regulates important genes involved in lung cancer cell growth, including a stem cell self-renewal gene, piwil1. In this article, we report the identification of small noncoding PIWI-interacting RNAs (piRNAs) in lung cancer cells over-expressing RASSF1C. A piRNA microarray screen was performed using RNA isolated from the lung cancer cell line H1299 stably over-expressing RASSF1C and corresponding control. The piRNA microarray screen identified several piRNAs that are regulated by RASSF1C and we have validated the expression of two up-regulated piRNAs (piR-34871 and piR-52200) and two down-regulated piRNAs (piR-35127 and piR-46545) in lung cancer cells with silenced and over-expressed RASSF1C using RT-PCR...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414749/sequence-variability-of-the-respiratory-syncytial-virus-rsv-fusion-gene-among-contemporary-and-historical-genotypes-of-rsv-a-and-rsv-b
#7
Anne M Hause, David M Henke, Vasanthi Avadhanula, Chad A Shaw, Lorena I Tapia, Pedro A Piedra
BACKGROUND: The fusion (F) protein of RSV is the major vaccine target. This protein undergoes a conformational change from pre-fusion to post-fusion. Both conformations share antigenic sites II and IV. Pre-fusion F has unique antigenic sites p27, ø, α2α3β3β4, and MPE8; whereas, post-fusion F has unique antigenic site I. Our objective was to determine the antigenic variability for RSV/A and RSV/B isolates from contemporary and historical genotypes compared to a historical RSV/A strain...
2017: PloS One
https://www.readbyqxmd.com/read/28413121/characterisation-of-cell-cycle-arrest-and-terminal-differentiation-in-a-maximally-proliferative-human-epithelial-tissue-lessons-from-the-human-hair-follicle-matrix
#8
Talveen S Purba, Lars Brunken, Michael Peake, Asim Shahmalak, Asuncion Chaves, Enrique Poblet, Ralf Paus
Human hair follicle (HF) growth and hair shaft formation require terminal differentiation-associated cell cycle arrest of highly proliferative matrix keratinocytes. However, the regulation of this complex event remains unknown. CIP/KIP family member proteins (p21(CIP1), p27(KIP1) and p57(KIP2)) regulate cell cycle progression/arrest, endoreplication, differentiation and apoptosis. Since they have not yet been adequately characterized in the human HF, we asked whether and where CIP/KIP proteins localise in the human hair matrix and pre-cortex in relation to cell cycle activity and HF-specific epithelial cell differentiation that is marked by keratin 85 (K85) protein expression...
April 2, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28412340/levan-promotes-antiproliferative-and-pro-apoptotic-effects-in-mcf-7-breast-cancer-cells-mediated-by-oxidative-stress
#9
Eveline A I F Queiroz, Zuleica B Fortes, Mário A A da Cunha, Hande Kazak Sarilmiser, Aneli M Barbosa, Ebru Toksoy Öner, Robert F H Dekker, Neelam Khaper
Exopolysaccharides are high-valued bio-products produced by various microbial species and have been described to possess biological response modifying activities. These bio-products have been effective as therapeutic agents in various human disease conditions. The objective of this study was to examine the effects of levan (a (2→6)-β-D-fructan) produced on sucrose by the halophilic bacterium, Halomonas smyrnensis AAD6(T), in human breast cancer MCF-7 cells. MCF-7 cells were exposed to levan for 24 and 48h...
April 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28408934/sdf-1-cxcr4-signaling-maintains-stemness-signature-in-mouse-neural-stem-progenitor-cells
#10
Shih-Yin Ho, Thai-Yen Ling, Hsing-Yu Lin, Jeffrey Tsai-Jui Liou, Fei-Chih Liu, I-Chun Chen, Sue-Wei Lee, Yu Hsu, Dar-Ming Lai, Horng-Huei Liou
SDF-1 and its primary receptor, CXCR4, are highly expressed in the embryonic central nervous system (CNS) and play a crucial role in brain architecture. Loss of SDF-1/CXCR4 signaling causes abnormal development of neural stem/progenitor cells (NSCs/NPCs) in the cerebellum, hippocampus, and cortex. However, the mechanism of SDF-1/CXCR4 axis in NSCs/NPCs regulation remains unknown. In this study, we found that elimination of SDF-1/CXCR4 transduction caused NSCs/NPCs to lose their stemness characteristics and to encounter neurogenic differentiation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28407767/e167k-polymorphism-of-tm6sf2-gene-affects-cell-cycle-of-hepatocellular-carcinoma-cell-hepa-1-6
#11
Shuixian Du, Linlin Lu, Yingxia Miao, Wenwen Jin, Changfei Li, Yongning Xin, Shiying Xuan
BACKGROUND: Some studties reported that the polymorphism of TM6SF2 gene E167K affects the occurrence and the progression of hepatocytes carcinoma (hepatocellular, HCC). In oeder to investigate the effects of the polymorphism of TM6SF2 gene E167K in the pathogenesis of HCC, we explored its influence on the cell cycle in hepatocellular carcinoma cell HEPA1-6. METHODS: HEPA 1-6 cells which could respectively overexpress TM6SF2 wild type and E167K variant were cultured and HEPA 1-6 cells with zero load plasmids were used as matched control...
April 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28407749/down-regulated-expression-of-opcml-predicts-an-unfavorable-prognosis-and-promotes-disease-progression-in-human-gastric-cancer
#12
Xiangbin Xing, Weibin Cai, Sanmei Ma, Yongfei Wang, Huijuan Shi, Ming Li, Jinxia Jiao, Yang Yang, Longshan Liu, Xiangliang Zhang, Minhu Chen
BACKGROUND: OPCML belongs to the IgLON family of Ig domain-containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear. METHODS: We assessed expression and biological behavior of OPCML in gastric cancer. RESULTS: OPCML expression was markedly reduced in tumor tissues and cancer cell lines. Decreased OPCML expression had a significant association with unfavorable tumor stage (p = 0...
April 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28407690/the-suppressing-effects-of-btg3-expression-on-aggressive-behaviors-and-phenotypes-of-colorectal-cancer-an-in-vitro-and-vivo-study
#13
Hua-Chuan Zheng, Hao-Yu He, Ji-Cheng Wu, Jing Li, Shuang Zhao, Gui-Feng Zhao, Hua-Mao Jiang, Xue-Wen Yu, Zhi-Jie Li
Here, we found that down-regulated expression of BTG3 might be positively correlated with colorectal carcinogenesis and its overexpression suppressed proliferation, glycolysis, mitochondrial respiration, cell cycle progression, migration, and invasion, and induced apoptosis, senescence and differentiation in SW480 and SW620 cells. After treated with cisplatin, MG132, paclitaxel and SAHA, BTG3 transfectants exhibited lower viability and higher apoptosis than the control in both time- and dose-dependent manners...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404905/osr1-is-a-novel-epigenetic-silenced-tumor-suppressor-regulating-invasion-and-proliferation-in-renal-cell-carcinoma
#14
Yixiang Zhang, Yeqing Yuan, Pei Liang, Xiaojing Guo, Ying Ying, Xing-Sheng Shu, Michael Gao, Yingduan Cheng
Renal cell carcinoma (RCC) is one of the most malignant tumors in human. Here, we found that odd-skipped related transcription factor 1 (OSR1) was downregulated in 769-P and 786-O cells due to promoter CpG methylation. OSR1 expression could be restored by pharmacological demethylation treatment in silenced cell lines. Knockdown of OSR1 in two normal expressed cell lines- A498 and ACHN promoted cell invasion and cellular proliferation. RNA-Sequencing analysis showed that expression profile of genes involved in multiple cancer-related pathways was changed when OSR1 was downregulated...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402854/in%C3%A2-vivo-interplay-between-p27-kip1-gata3-atoh1-and-pou4f3-converts-non-sensory-cells-to-hair-cells-in-adult-mice
#15
Bradley J Walters, Emily Coak, Jennifer Dearman, Grace Bailey, Tetsuji Yamashita, Bryan Kuo, Jian Zuo
Hearing loss is widespread and persistent because mature mammalian auditory hair cells (HCs) are nonregenerative. In mice, the ability to regenerate HCs from surrounding supporting cells (SCs) declines abruptly after postnatal maturation. We find that combining p27(Kip1) deletion with ectopic ATOH1 expression surmounts this age-related decline, leading to conversion of SCs to HCs in mature mouse cochleae and after noise damage. p27(Kip1) deletion, independent of canonical effects on Rb-family proteins, upregulated GATA3, a co-factor for ATOH1 that is lost from SCs with age...
April 11, 2017: Cell Reports
https://www.readbyqxmd.com/read/28402264/fhl2-interacts-with-iaspp-and-impacts-the-biological-functions-of-leukemia-cells
#16
Wenting Lu, Tengteng Yu, Shuang Liu, Saisai Li, Shouyun Li, Jia Liu, Yingxi Xu, Haiyan Xing, Zheng Tian, Kejing Tang, Qing Rao, Jianxiang Wang, Min Wang
iASPP is an inhibitory member of apoptosis-stimulating proteins of p53 (ASPP) family, which inhibits p53-dependent apoptosis. iASPP was highly expressed in acute leukemia, inhibited leukemia cells apoptosis and promoted leukemogenesis. In order to clarify its mechanism, a yeast two-hybrid screen was performed and FHL2 was identified for the first time as one of the binding proteins of iASPP. FHL2 was highly expressed in K562 and Kasumi-1 cells. FHL2 and iASPP interacted with each other and co-localized in both nucleus and cytoplasm...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401225/new-insights-into-the-molecular-mechanism-of-boletus-edulis-ribonucleic-acid-fraction-be3-concerning-antiproliferative-activity-on-human-colon-cancer-cells
#17
Marta Kinga Lemieszek, Miguel Ribeiro, Guilhermina Marques, Fernando Milheiro Nunes, Piotr Pożarowski, Wojciech Rzeski
One of the relatively new and promising strategies of cancer treatment is chemoprevention, which involves the use of natural or synthetic compounds to block, inhibit or reverse carcinogenesis. A valuable and still untapped source of chemopreventive compounds seems to be edible mushrooms belonging to higher Basidiomycetes. Boletus edulis biopolymers extracted with hot water and purified by anion-exchange chromatography showed antiproliferative activity in colon cancer cells, but only fraction BE3, mostly composed of ribonucleic acids, was able to inhibit DNA synthesis in HT-29 cells...
April 12, 2017: Food & Function
https://www.readbyqxmd.com/read/28388564/antiproliferative-effect-of-zstk474-alone-or-in-combination-with-chemotherapeutic-drugs-on-hl60-and-hl60-adr-cells
#18
Qianxiang Zhou, Yali Chen, Lei Zhang, Yuxu Zhong, Zhe Zhang, Ran Wang, Meihua Jin, Min Gong, Yuling Qiu, Dexin Kong
While chemotherapy remains to be one of the main approaches in the clinical treatment of acute myeloid leukemia (AML), multidrug resistance (MDR) has become a serious problem which limits the therapeutic efficacy. The important roles of the PI3K/Akt pathway in modulating cell proliferation and MDR suggest that PI3K inhibitor might be effective for treatment of AML. In the present study, the antiproliferative effects of PI3K inhibitor ZSTK474 on AML cell HL60 and the adriamycin (ADR)-resistant HL60/ADR cells were investigated...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28388558/expression-of-estrogen-receptors-and-androgen-receptor-and-their-clinical-significance-in-gastric-cancer
#19
Wenbo Tang, Rujiao Liu, Yan Yan, Xiaoli Pan, Minjun Wang, Xiaotian Han, Hui Ren, Zhe Zhang
Despite the mounting studies exploring the role of estrogen receptor alpha (ERα), estrogen receptor beta (ERβ) and androgen receptor (AR) in gastric cancer (GC), there remain controversies in those findings. The present study investigated the expression of ERα, ERβ and AR in Chinese gastric cancer by immunohistochemistry, analyzed their clinical relevance in gastric cancer, and examined the potential mechanisms by which ERα and AR modulated GC progression. The positive rate of ERα, ERβ and AR in GC tissues was 6% (9/150), 93...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386317/alisertib-induces-g2-m-arrest-apoptosis-and-autophagy-via-pi3k-akt-mtor-and-p38-mapk-mediated-pathways-in-human-glioblastoma-cells
#20
Zheng Liu, Feng Wang, Zhi-Wei Zhou, He-Chun Xia, Xin-Yu Wang, Yin-Xue Yang, Zhi-Xu He, Tao Sun, Shu-Feng Zhou
Glioblastoma (GBM) is the most common brain tumor with poor response to current therapeutics. Alisertib (ALS), a second-generation selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects on solid tumors in animal studies. This study aimed to investigate the killing effect of ALS on GBM cell line DAOY and the possible underlying mechanisms using both bioinformatic and cell-based approaches. Our molecular docking showed that ALS preferentially bound AURKA over AURKB via hydrogen bond formation, charge interaction, and π-π stacking...
2017: American Journal of Translational Research
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