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https://www.readbyqxmd.com/read/27760255/association-of-preoperative-risk-factors-with-malignancy-in-pancreatic-mucinous-cystic-neoplasms-a-multicenter-study
#1
Lauren M Postlewait, Cecilia G Ethun, Mia R McInnis, Nipun Merchant, Alexander Parikh, Kamran Idrees, Chelsea A Isom, William Hawkins, Ryan C Fields, Matthew Strand, Sharon M Weber, Clifford S Cho, Ahmed Salem, Robert C G Martin, Charles Scoggins, David Bentrem, Hong J Kim, Jacquelyn Carr, Syed Ahmad, Daniel E Abbott, Gregory C Wilson, David A Kooby, Shishir K Maithel
Importance: Pancreatic mucinous cystic neoplasms (MCNs) harbor malignant potential, and current guidelines recommend resection. However, data are limited on preoperative risk factors for malignancy (adenocarcinoma or high-grade dysplasia) occurring in the setting of an MCN. Objectives: To examine the preoperative risk factors for malignancy in resected MCNs and to assess outcomes of MCN-associated adenocarcinoma. Design, Setting, and Participants: Patients who underwent pancreatic resection of MCNs at the 8 academic centers of the Central Pancreas Consortium from January 1, 2000, through December 31, 2014, were retrospectively identified...
October 19, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27154811/perception-is-reality-quality-metrics-in-pancreas-surgery-a-central-pancreas-consortium-cpc-analysis-of-1399-patients
#2
Daniel E Abbott, Grace Martin, David A Kooby, Nipun B Merchant, Malcolm H Squires, Shishir K Maithel, Sharon M Weber, Emily R Winslow, Clifford S Cho, David J Bentrem, Hong Jin Kim, Charles R Scoggins, Robert C Martin, Alexander A Parikh, William G Hawkins, Syed A Ahmad
INTRODUCTION: Several groups have defined pancreatic surgery quality metrics that identify centers delivering quality care. Although these metrics are perceived to be associated with good outcomes, their relationship with actual outcomes has not been established. METHODS: A national cadre of pancreatic surgeons was surveyed regarding perceived quality metrics, which were evaluated against the Central Pancreas Consortium (CPC) database to determine actual performance and relationships with long-term outcomes...
May 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/25115425/value-of-intraoperative-neck-margin-analysis-during-whipple-for-pancreatic-adenocarcinoma-a-multicenter-analysis-of-1399-patients
#3
MULTICENTER STUDY
David A Kooby, Neha L Lad, Malcolm H Squires, Shishir K Maithel, Juan M Sarmiento, Charles A Staley, N Volkan Adsay, Bassel F El-Rayes, Sharon M Weber, Emily R Winslow, Clifford S Cho, Kathryn A Zavala, David J Bentrem, Mark Knab, Syed A Ahmad, Daniel E Abbott, Jeffrey M Sutton, Hong Jin Kim, Jen Jen Yeh, Rachel Aufforth, Charles R Scoggins, Robert C Martin, Alexander A Parikh, Jamie Robinson, Yassar M Hashim, Ryan C Fields, William G Hawkins, Nipun B Merchant
INTRODUCTION: During pancreaticoduodenectomy (PD) for ductal adenocarcinoma, a frozen section (FS) neck margin is typically assessed, and if positive, additional pancreas is removed to achieve an R0 margin. We analyzed the association of this practice with improved overall survival (OS). METHODS: Patients who underwent PD for pancreatic ductal adenocarcinoma from January 2000 to August 2012 at 8 academic centers were classified by neck margin status as negative (R0) or microscopically positive (R1) on the basis of FS and permanent section (PS)...
September 2014: Annals of Surgery
https://www.readbyqxmd.com/read/24944151/perioperative-blood-transfusion-is-associated-with-decreased-survival-in-patients-undergoing-pancreaticoduodenectomy-for-pancreatic-adenocarcinoma-a-multi-institutional-study
#4
MULTICENTER STUDY
Jeffrey M Sutton, David A Kooby, Gregory C Wilson, M Hart Squires, Dennis J Hanseman, Shishir K Maithel, David J Bentrem, Sharon M Weber, Clifford S Cho, Emily R Winslow, Charles R Scoggins, Robert C G Martin, Hong Jin Kim, Justin J Baker, Nipun B Merchant, Alexander A Parikh, Daniel E Abbott, Michael J Edwards, Syed A Ahmad
INTRODUCTION: In this multi-institutional study of patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma, we sought to identify factors associated with perioperative transfusion requirement as well as the association between blood transfusion and perioperative and oncologic outcomes. METHODS: The surgical databases across six high-volume institutions were analyzed to identify patients who underwent pancreaticoduodenectomy for pancreatic adenocarcinoma from 2005 to 2010...
September 2014: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/23620151/vein-involvement-during-pancreaticoduodenectomy-is-there-a-need-for-redefinition-of-borderline-resectable-disease
#5
COMPARATIVE STUDY
Kaitlyn J Kelly, Emily Winslow, David Kooby, Neha L Lad, Alexander A Parikh, Charles R Scoggins, Syed Ahmad, Robert C Martin, Shishir K Maithel, H J Kim, Nipun B Merchant, Clifford S Cho, Sharon M Weber
INTRODUCTION: Current National Comprehensive Cancer Network guidelines recommend neoadjuvant therapy for borderline resectable pancreatic adenocarcinoma to increase the likelihood of achieving R0 resection. A consensus has not been reached on the degree of venous involvement that constitutes borderline resectability. This study compares the outcome of patients who underwent pancreaticoduodenectomy with or without vein resection without neoadjuvant therapy. METHODS: A multi-institutional database of patients who underwent pancreaticoduodenectomy was reviewed...
July 2013: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/22868373/factors-influencing-readmission-after-pancreaticoduodenectomy-a-multi-institutional-study-of-1302-patients
#6
MULTICENTER STUDY
Syed A Ahmad, Michael J Edwards, Jeffrey M Sutton, Sanjeet S Grewal, Dennis J Hanseman, Shishir K Maithel, Sameer H Patel, David J Bentram, Sharon M Weber, Clifford S Cho, Emily R Winslow, Charles R Scoggins, Robert C Martin, Hong Jin Kim, Justin J Baker, Nipun B Merchant, Alexander A Parikh, David A Kooby
OBJECTIVE AND BACKGROUND: Morbidity, mortality, and length of hospital stay after pancreaticoduodenectomy (PD) have significantly decreased over recent decades. Despite this progress, early readmission rates after PD have been reported as high as 50%. Few reports have delineated factors associated with readmission after PD. METHODS: The medical records of 6 high-volume institutions were reviewed for patients who underwent PD between 2005 and 2010. Data collection included patient characteristics, medical comorbidities, and perioperative factors...
September 2012: Annals of Surgery
https://www.readbyqxmd.com/read/22404260/multi-institutional-analysis-of-pancreatic-adenocarcinoma-demonstrating-the-effect-of-diabetes-status-on-survival-after-resection
#7
MULTICENTER STUDY
Robert M Cannon, Ryan LeGrand, Ryaz B Chagpar, Syed A Ahmad, Rebecca McClaine, Hong Jin Kim, Christopher Rupp, Cliff S Cho, Adam Brinkman, Sharon Weber, Emily R Winslow, David A Kooby, Carrie K Chu, Charles A Staley, Ian Glenn, William G Hawkins, Alexander A Parikh, Nipun B Merchant, Kelly M McMasters, Robert C G Martin, Glenda G Callender, Charles R Scoggins
BACKGROUND: The effect of diabetes on survival after resection pancreatic ductal carcinoma (PDAC) is unclear. The present study was undertaken to determine whether pre-operative diabetes has any predictive value for survival. METHODS: A retrospective review from seven centres was performed. Metabolic factors, tumour characteristics and outcomes of patients undergoing resection for PDAC were collected. Univariate and multivariable analyses were performed to determine factors associated with disease-free (DFS) and overall survival (OS)...
April 2012: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/21394014/laparoscopic-versus-open-left-pancreatectomy-can-preoperative-factors-indicate-the-safer-technique
#8
MULTICENTER STUDY
Clifford S Cho, David A Kooby, C Max Schmidt, Attila Nakeeb, David J Bentrem, Nipun B Merchant, Alexander A Parikh, Ronald C G Martin, Charles R Scoggins, Syed A Ahmad, Hong J Kim, Nicholas Hamilton, William G Hawkins, Sharon M Weber
BACKGROUND: Laparoscopic left pancreatectomy (LLP) is associated with favorable outcomes compared with open left pancreatectomy (OLP). However, it is unclear if the risk factors associated with operative morbidity differ between these two techniques. Guidelines for determining which patients should undergo OLP versus LLP do not exist. METHODS: A multi-institutional analysis of OLP and LLP performed in 9 academic medical centers was undertaken. LLP cases were defined in an intent-to-treat manner...
May 2011: Annals of Surgery
https://www.readbyqxmd.com/read/21103949/analysis-of-6-747-pancreatic-neuroendocrine-tumors-for-a-proposed-staging-system
#9
COMPARATIVE STUDY
Robert C G Martin, David A Kooby, Sharon M Weber, Nipun B Merchant, Alex A Parikh, Clifford S Cho, Syed A Ahmad, Hong Jin Kim, William Hawkins, Charles R Scoggins
OBJECTIVES: Currently, no reasonable staging system exists for pancreatic neuroendocrine tumors (PNET) to guide treating physicians. The aim of this study was to devise a staging system of relevant prognostic factors to better predict overall survival in PNET. METHODS: A prospective 300 patient cohort and a review of the Surveillance Epidemiology and End Results database identified 6,447 patients with PNET from 1973 to 2008. Significant prognostic factors were created for an initial...
January 2011: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/20421049/a-multicenter-analysis-of-distal-pancreatectomy-for-adenocarcinoma-is-laparoscopic-resection-appropriate
#10
MULTICENTER STUDY
David A Kooby, William G Hawkins, C Max Schmidt, Sharon M Weber, David J Bentrem, Theresa W Gillespie, Johnita Byrd Sellers, Nipun B Merchant, Charles R Scoggins, Robert C G Martin, Hong Jin Kim, Syed Ahmad, Clifford S Cho, Alexander A Parikh, Carrie K Chu, Nicholas A Hamilton, Courtney J Doyle, Scott Pinchot, Amanda Hayman, Rebecca McClaine, Attila Nakeeb, Charles A Staley, Kelly M McMasters, Keith D Lillemoe
BACKGROUND: As compared with open distal pancreatectomy (ODP), laparoscopic distal pancreatectomy (LDP) affords improved perioperative outcomes. The role of LDP for patients with pancreatic ductal adenocarcinoma (PDAC) is not defined. STUDY DESIGN: Records from patients undergoing distal pancreatectomy (DP) for PDAC from 2000 to 2008 from 9 academic medical centers were reviewed. Short-term (node harvest and margin status) and long-term (survival) cancer outcomes were assessed...
May 2010: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/19609621/laparoscopic-left-pancreatectomy-complication-risk-score-correlates-with-morbidity-and-risk-for-pancreatic-fistula
#11
MULTICENTER STUDY
Sharon M Weber, Clifford S Cho, Nipun Merchant, Scott Pinchot, Robert Rettammel, Atilla Nakeeb, David Bentrem, Alex Parikh, Ashley E Mazo, Robert C G Martin, Charles R Scoggins, Syed A Ahmad, Hong Jin Kim, Nicholas Hamilton, William Hawkins, C Max Schmidt, David A Kooby
BACKGROUND: Surgeons are performing laparoscopic left pancreatectomy (LLP) with increasing frequency; however, determinants of perioperative outcome after LLP are not well defined. We evaluated factors contributing to morbidity after LLP. METHODS: Records from patients undergoing LLP from 2000 to 2008 from nine academic medical centers were evaluated to assess risk factors for perioperative complications. Extent of pancreatic resection was determined by the length of the gross pancreatic specimen...
October 2009: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/19476845/adjuvant-chemoradiation-therapy-for-pancreatic-adenocarcinoma-who-really-benefits
#12
MULTICENTER STUDY
Nipun B Merchant, Jennifer Rymer, Elizabeth A S Koehler, G Daniel Ayers, Jason Castellanos, David A Kooby, Sharon H Weber, Clifford S Cho, C Max Schmidt, Atilla Nakeeb, Jesus M Matos, Charles R Scoggins, Robert C G Martin, Hong Jin Kim, Syed A Ahmad, Carrie K Chu, Rebecca McClaine, Brian K Bednarski, Charles A Staley, Kenneth Sharp, Alexander A Parikh
BACKGROUND: The role of adjuvant chemoradiation therapy (CRT) in pancreatic cancer remains controversial. The primary aim of this study was to determine if CRT improved survival in patients with resected pancreatic cancer in a large, multiinstitutional cohort of patients. STUDY DESIGN: Patients undergoing resection for pancreatic adenocarcinoma from seven academic medical institutions were included. Exclusion criteria included patients with T4 or M1 disease, R2 resection margin, preoperative therapy, chemotherapy alone, or if adjuvant therapy status was unknown...
May 2009: Journal of the American College of Surgeons
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