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Osteoporosis

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https://www.readbyqxmd.com/read/29244134/consensus-guidelines-for-the-treatment-of-osteoporosis
#1
Michael Paci, Shelby Burks, Michael Y Wang
No abstract text is available yet for this article.
January 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29243437/-intervention-effects-of-zuoguiwan-containing-serum-on-osteoblast-through-erk1-2-and-wnt-%C3%AE-catenin-signaling-pathway-in-models-with-kidney-yang-deficiency-kidney-yin-deficiency-osteoporosis-syndromes
#2
Jian-Hua Zhang, Jing Xin, Lian-Xia Fan, Hua Yin
To clarify the effects of Zuoguiwan containing serum on osteoblast proliferation and alkaline phosphatase(ALP) expression and its effects on the expression of β-catenin, ERK1, ERK2 mRNA and protein of osteoblast through ERK1/2, Wnt/β-catenin signaling pathway in models with osteoporosis(OP) kidney-Yang-deficiency, osteoporosis(OP) kidney-Yin-deficiency syndrome. Rat osteoporosis models were established by ovariectomy surgery, and 10 weeks after surgery, hydrocortisone was injected and thyroxine was administered by intragastric administration to establish OP kidney-Yang-deficiency rat model, and OP kidney-Yin-deficiency rat model...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29242963/effect-of-strontium-ranelate-on-the-muscle-and-vertebrae-of-ovariectomized-rats
#3
D Saul, B Harlas, A Ahrabi, R L Kosinsky, D B Hoffmann, M Wassmann, R Wigger, K O Böker, S Sehmisch, M Komrakova
Osteoporosis is often accompanied by sarcopenia. The effect of strontium ranelate (SR) on muscle tissue has not been investigated sufficiently. In this study, the effect of different SR treatments on muscle was studied. Additionally, the lumbar vertebrae were analyzed. Three-month-old female rats were divided into five groups (n = 12): Group 1: untreated (NON-OVX); Group 2: ovariectomized and left untreated (OVX); Group 3: SR after OVX until the study ended (13 weeks, SR prophylaxis and therapy = pr+th); Group 4: OVX and SR for 8 weeks (SR prophylaxis = pr); Group 5: SR for 5 weeks from the 8 week after OVX (SR therapy = SR th)...
December 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29242796/bilateral-femoral-neck-fractures-in-cerebrotendinous-xanthomatosis-treated-by-hip-arthroplasties-the-first-case-report-and-literature-review
#4
Witchuree Wejjakul, Swist Chatmaitri, Thongek Wattanarojanaporn, Anuwat Pongkunakorn, Chupong Ittiwut, Vorasuk Shotelersuk
Introduction: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disease caused by mutations of the CYP27A1 gene and deficiency of the sterol-27-hydroxylase enzyme in bile acid biosynthesis. It is characterized by the accumulation of cholestanol and bile alcohols in plasma, the formation of xanthomatous lesions in various tissues, and organ degeneration. This disorder is also associated with osteoporosis and increased risk of fracture. To date, only two CTX patients with femoral neck fractures have been reported...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242792/minimal-invasive-dynamic-hip-screw-fixation-technique-in-patient-with-cardiac-complications-a-case-scenario
#5
Ponnusami Pillai Gokulakrishnan, Anil Gowtham Manivannan, Sakthivel Annamalai, Balaji Umamaheshwaran
Introduction: Intertrochanteric fracture comprises nearly half of hip fractures occurring in elderly individuals with osteoporosis. Considering the age group of its population, they are often associated with multiple comorbidities which warrant optimum management with less surgical. Case Report: This article reports the case of 56-year-old women with in tertrochanteric fracture associated with the cardiac complication restricting operating duration. Minimal invasive dynamic hip screw (MIDHS) fixation technique with modified instruments was performed which facilitated minimizing the operating time and intraoperative blood loss...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242787/foot-deformities-in-hajdu-cheney-syndrome-a-rare-case-report-and-review-of-the-literature
#6
Ashish B Shah, Breann K Tisano, Osama Elattar, Jackson Rucker Staggers, Sameer Naranje
Introduction: Hajdu-Cheney syndrome (HCS) is a rare autosomal dominant disease characterized by acroosteolysis, wormian skull bones with persistent skull sutures, premature loss of teeth, micrognathia, short stature, hypermobility of the joints, neurologic manifestations such as basilar invagination with subsequent paresthesia, hearing loss, and speech alterations, and osteoporosis with tendency to pathologic fractures of long bones and vertebrae as well as painful hands and feet. Very few cases have been earlier reported in the literature...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242565/anti-il-20-monoclonal-antibody-inhibited-tumor-growth-in-hepatocellular-carcinoma
#7
Yi-Shu Chiu, Chung-Hsi Hsing, Chien-Feng Li, Chon-Yee Lee, Yu-Hsiang Hsu, Ming-Shi Chang
Interleukin (IL)-20 is a proinflammatory cytokine involved in rheumatoid arthritis, atherosclerosis, and osteoporosis. However, the role of IL-20 in hepatocellular carcinoma (HCC) is unclear. We explored the function of IL-20 in HCC. Tumor tissue samples were analyzed the expression of IL-20 and cyclin D1 by using immunohistochemistry staining and quantitative real-time polymerase chain reaction (qRT-PCR) analysis. To examine the role of anti-IL-20 monoclonal antibody (7E) in tumor growth, BALB/c mice was injected with ML-1 cells and treated with 7E...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242516/mronj-risk-of-adjuvant-bisphosphonates-in-early-stage-breast-cancer
#8
V Patel, J Mansi, S Ghosh, J Kwok, M Burke, D Reilly, N Nizarali, C Sproat, K Chia
Medication-related osteonecrosis of the jaw (MRONJ) has most commonly been associated with bisphosphonates. The routine uses of these drugs are now well established predominantly in metastatic cancer with bone involvement, multiple myeloma, hypercalcaemia, osteoporosis and Paget's disease. Recently, however, the use of bisphosphonates in early breast cancer has shown a reduction in breast cancer recurrence and breast cancer deaths. This new indication for their use approximates to a further 20,000 women per year in the UK being prescribed bisphosphonates...
December 15, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29241936/teriparatide-and-denosumab-treatment-for-pregnancy-and-lactation-associated-osteoporosis-with-multiple-vertebral-fractures-a-case-study
#9
Akifumi Ijuin, Hiromi Yoshikata, Ryoko Asano, Taku Tsuburai, Ritsuko Kikuchi, Hideya Sakakibara
OBJECTIVE: Pregnancy and lactation-associated osteoporosis (PLO) is a rare disease, which can lead to vertebral fractures in women of reproductive age. No treatment strategy for PLO has been established. Here we report a case of PLO treated with teriparatide followed by denosumab, in which remarkable improvement in bone mineral density (BMD) was achieved. CASE REPORT: A 27-year-old woman experienced severe back pain two weeks after her first delivery. PLO was diagnosed from her low BMD and multiple vertebral compression fractures...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241825/sex-hormones-are-negatively-associated-with-vertebral-bone-marrow-fat
#10
Swaroop D Mistry, Gina N Woods, Sigurdur Sigurdsson, Susan K Ewing, Trisha F Hue, Gudny Eiriksdottir, Kaipin Xu, Joan F Hilton, Deborah M Kado, Vilmundur Gudnason, Tamara B Harris, Clifford J Rosen, Thomas F Lang, Xiaojuan Li, Ann V Schwartz
CONTEXT: Higher bone marrow fat (BMF)1 is associated with osteoporosis and reduced hematopoiesis. Exogenous estradiol reduces BMF in older women, but effects of endogenous sex hormones are unknown. OBJECTIVE: To determine if endogenous sex hormones are associated with BMF in older men and women. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study in the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort. Participants using medications that may affect BMF were excluded...
December 11, 2017: Bone
https://www.readbyqxmd.com/read/29241503/psychometric-properties-of-belief-measures-about-osteoporosis-and-its-control
#11
Lacey Alexander, Piyaorn Wajanatinapart, Diane Lauver
BACKGROUND AND PURPOSE: Osteoporosis (OP) is a chronic health condition with potentially serious consequences. Although preventive behaviors are important to control OP, many people do not engage in such behaviors. Although beliefs about preventive behaviors for OP influence such behaviors, we could not find psychometrically strong measures of such beliefs for use in planned research. Our initial study was done to assess the content validity, clarity, and internal consistency of belief measures regarding behaviors to control OP: perceived competence, perceived susceptibility, and perceived severity, based on relevant theories...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29241341/abaloparatide-review-of-a-next-generation-parathyroid-hormone-agonist
#12
Eric G Boyce, Yvonne Mai, Christopher Pham
OBJECTIVE: To review the efficacy, safety, and economics of abaloparatide in the treatment of postmenopausal osteoporosis. DATA SOURCES: PubMed (1966 to October 2017), Clinicaltrials.gov (October 2017), and Scopus (1970 to October 2017) were searched using abaloparatide, Tymlos, BA058, PTHrP 1-34 analog, and parathyroid hormone-related peptide 1-34 analog. STUDY SELECTION AND DATA EXTRACTION: Human studies published in peer-reviewed publications in English were the primary sources for efficacy, safety, and economic data...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29241149/a-novel-use-of-3d-printing-model-demonstrates-the-effects-of-deteriorated-trabecular-bone-structure-on-bone-stiffness-and-strength
#13
Meir Max Barak, Margaret Arielle Black
Trabecular bone structure is crucial to normal mechanical behavior of bones. Studies have shown that osteoporosis negatively affects trabecular bone structure, mainly by reducing bone volume fraction (BV/TV) and thus increasing fracture risk. One major limitation in assessing and quantifying the effect of this structural deterioration is that no two trabecular structures are identical. Thus, when we compare a group of healthy bones against a different group of bones that experienced resorption (i.e. decreased BV/TV) we only discover an "average" mechanical effect...
December 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29241074/sall4-promotes-osteoblast-differentiation-by-deactivating-notch2-signaling
#14
Wei Yu, Dianming Jiang, Yu Shaobin, Fu Jiabin, Zhijun Li, Yuchi Wu, Yulong Wang
BACKGROUND: The Spalt-Like Transcription Factor 4 (SALL4) is reported to regulate cell proliferation, migration and invasion. However, the roles of SALL4 in osteoblast differentiation are unclear. This study was aimed to explore the underlying mechanism of SALL4 in osteoporosis. METHODS: Firstly, the expression of SALL4 was assessed in vivo and in vitro at various stages of development of rats (E14, E20, postnatal 2, 4, and 9 day) or different incubation time (0, 6, 9, 12 and 15 day) of C2C12 and MC3T3-E1 cells...
December 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29240982/multi-dimensional-bone-density-phenotyping-reveals-new-insights-in-to-genetic-regulation-of-the-pediatric-skeleton
#15
Jonathan A Mitchell, Alessandra Chesi, Diana L Cousminer, Shana E McCormack, Heidi J Kalkwarf, Joan M Lappe, Vicente Gilsanz, Sharon E Oberfield, John A Shepherd, Andrea Kelly, Babette S Zemel, Struan F A Grant
Osteoporosis is a complex disease with developmental origins. It is therefore important to understand the genetic contribution to pediatric areal bone mineral density (aBMD). Individual skeletal site phenotyping has been primarily used to identify pediatric aBMD loci. However, this approach is limited because there is a degree of aBMD discordance across skeletal sites. We, therefore, applied a novel multi-dimensional phenotyping approach to further understand the genetic regulation of pediatric aBMD. Our sample comprised a prospective, longitudinal cohort of 1,293 children of European ancestry (52% female; up to 7 annual measurements)...
December 14, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29240803/bone-edema-on-magnetic-resonance-imaging-is-highly-associated-with-low-bone-mineral-density-in-patients-with-ankylosing-spondylitis
#16
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29239997/predisposing-risk-factors-and-stress-fractures-in-division-i-cross-country-runners
#17
Kaci L Giffin, Kathy B Knight, Martha A Bass, Melinda W Valliant
The purpose of this study was to explore factors associated with increased stress fractures in collegiate cross country runners. Participants in this study were 42 male and female cross country runners at a Division I university. Each athlete completed a questionnaire regarding smoking status, vitamin/mineral intake, previous stress fracture history, birth control usage, menstrual status, and demographic information. Nutritional assessment via a 3-day food record and measurements of whole body, lumbar spine, and hip bone mineral densities (BMD) were also conducted on each athlete...
November 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239893/switch-from-tenofovir-disoproxil-fumarate-combination-to-dolutegravir-plus-rilpivirine-improves-parameters-of-bone-health
#18
Grace A Mccomsey, Sergio Lupo, David Parks, Mónica Coronado Poggio, Joseph De Wet, Lesley P Kahl, Kostas Angelis, Brian Wynne, Kati Vandermeulen, Martin Gartland, Michael Cupo, Michael Aboud
OBJECTIVE: Bone mineral density (BMD) loss, a risk factor for osteoporosis, has been attributed to HIV infection and antiretroviral therapy (ART), including regimens containing tenofovir disoproxil fumarate. DESIGN: Study 202094 is an open-label, parallel-group, sub-study of the phase III SWORD-1 and SWORD-2 studies (ClincialTrials.gov identifier, NCT02478632). METHODS: HIV-1-infected adults with HIV-1 RNA < 50 copies per mL who received ART containing tenofovir disoproxil fumarate for ≥6 months were randomized to receive dolutegravir+rilpivirine or continue current ART regimen...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239351/association-of-serum-uric-acid-levels-with-osteoporosis-and-bone-turnover-markers-in-a-chinese-population
#19
Dan-Dan Yan, Jie Wang, Xu-Hong Hou, Yu-Qian Bao, Zhen-Lin Zhang, Cheng Hu, Wei-Ping Jia
Recent evidence shows that uric acid is protective against some neurological diseases, but can be detrimental in many metabolic and cardiovascular disorders. In this study, we examined the association between serum uric acid levels and bone metabolism in Chinese males and postmenopausal females. A total of 943 males and 4256 postmenopausal females were recruited in Shanghai. The levels of serum uric acid and bone turnover markers (BTMs) were detected along with other biochemical traits. In addition, the fat distribution was calculated through MRI and image analysis software, and bone mineral density (BMD) was determined using dual-energy X-ray absorptiometry...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29239241/tuberculous-spondylitis-after-vertebral-augmentation-a-case-report-with-a-literature-review
#20
Sun Jia-Jia, Sun Zhi-Yong, Qian Zhong-Lai, Yang Hui-Lin, Zhu Xiao-Yu
Tuberculous spondylitis of vertebral augmentation following percutaneous vertebroplasty or kyphoplasty is rare. We report an unusual case of tuberculous spondylitis diagnosed after percutaneous kyphoplasty (PKP). A 54-year-old woman presented to hospital complaining of back pain following a fall 20 days prior. Radiology showed an acute osteoporotic compression (L3 fracture). The patient denied a history of pulmonary tuberculosis and there were no signs of infection. The patient was discharged from hospital 2 days after undergoing L3 PKP with a dramatic improvement in her back pain...
January 1, 2017: Journal of International Medical Research
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