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Osteoporosis

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https://www.readbyqxmd.com/read/29458123/osteocyte-regulation-of-bone-and-blood
#1
REVIEW
Paola Divieti Pajevic, Daniela S Krause
This past decade has witnessed a renewed interest in the function and biology of matrix-embedded osteocytes and these cells have emerged as master regulators of bone homeostasis. They secrete two very powerful proteins, sclerostin, a Wnt-inhibitor, that suppresses bone formation, and receptor-activator of NF-kB ligand (RANKL), a cytokine required for osteoclastogenesis. Neutralizing antibodies against these proteins are currently used for the treatment of osteoporosis. Recent studies however, ascribed yet another function to osteocytes: the control of hematopoiesis and the HSPC niche, directly and through secreted factors...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29457433/-effect-of-50-hz-1-8-mt-sinusoidal-electromagnetic-fields-on-bone-mineral-density-in-growing-rats
#2
Yu-Hai Gao, Yan-Feng Zhou, Shao-Feng Li, Wen-Yuan Li, Hui-Rong Xi, Fang-Fang Yang, Ke-Ming Chen
OBJECTIVE: To study effects of 50 Hz 1.8 mT sinusoidal electromagnetic fields (SEMFs) on bone mineral density (BMD) in SD rats. METHODS: Thirty SD rats weighted(110±10) and aged 1 month were randomly divided into control group and electromagnetic field group, 15 in each group. Normal control group of 50 Hz 0 mT density and sinusoidal electromagnetic field group of 50 Hz 1.8 mT were performed respectively with 1.5 h/d and weighted weight once a week, and observed food-intake...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457413/-clinical-observation-of-proximal-femoral-anti-rotation-nail-for-the-treatment-of-femoral-intertrochanteric-fracture
#3
Fang-Gui Sun, De-Xin Wang, Yu-Tong Hu, Rong-Ming Xu
OBJECTIVE: To explore the curative effect and the recessive loss of blooding of PFNA for the treatment of intertrochanteric fractures of femur. METHODS: From January 2012 to January 2015, a total of 49 patients with intertrochanteric fractures of femur were treated with proximal femoral anti-rotation nail including 41 males and 8 females with an average age of 79 years old ranging from 65 to 91 years old. According to the modified Evans type, 1 case was type I, 12 cases were type II, 36 cases were type III...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457300/glucagon-like-peptide-2-decreases-osteoclasts-by-stimulating-apoptosis-dependent-on-nitric-oxide-synthase
#4
Yi Lu, Dongdong Lu, Yu Hu
OBJECTIVES: Glucagon-like peptide 2 (GLP2) is involved in the regulation of energy absorption and metabolism. Despite the importance of the GLP2 signalling mechanisms on osteoclast, little has been studied on how GLP2 works during osteoclastogenesis. MATERIALS AND METHODS: RAW264.7 cells were infected with rLV-Green-GLP2. The induction of osteoclasts was performed by RANKL. TRAP were detected by RT-PCR, Western blotting and staining. Total nitric oxide and total NOS activity were measured...
February 19, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29456639/analysis-of-effect-of-1%C3%AE-hydroxyvitamin-d3-on-benign-paroxysmal-positional-vertigo-and-risk-factors
#5
Xiang Gu, Feilin Dong, Jianhua Gu
The purpose of this study was to investigate the curative effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). Fifty BPPV patients diagnosed in the ENT Department of Anzhen Hospital from October 2015 to December 2016 were randomly selected as the treatment group, and treated with 0.25 µg 1α-hydroxyvitamin D3 once per day, in addition to the routine diagnosis and treatment. Moreover, 50 BPPV patients in the same period were selected as the control group, and received the routine diagnosis and treatment...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456437/a-tabletop-persistent-mode-liquid-helium-free-1-5-t-90-mm-mgb-2-finger-mri-magnet-for-osteoporosis-screening-two-design-options
#6
Dongkeun Park, Juan Bascuñán, Philip C Michael, Yukikazu Iwasa
In this paper we present two design options for a tabletop liquid-helium-free, persistent-mode 1.5-T/90-mm MgB2 "finger" MRI magnet for osteoporosis screening. Both designs, one with and the other without an iron yoke, satisfy the following criteria: 1) 1.5-T center field with a 90-mm room-temperature bore for a finger to be placed at the magnet center; 2) spatial field homogeneity of <5 ppm over a 20-mm diameter of spherical volume (DSV); 3) persistent-mode operation with temporal stability of <0...
April 2018: IEEE Transactions on Applied Superconductivity: a Publication of the IEEE Superconductivity Committee
https://www.readbyqxmd.com/read/29455515/-research-on-promotory-effect-of-traditional-chinese-medicine-on-fracture-healing-in-cell-and-molecular-level
#7
REVIEW
Kun Zhang, Liang-Chen Niu, Fu-Jie Yuan, Shen-Peng Liu
Traditional Chinese medicine is widely used in the treatment of fractures, osteoporosis, other bone related diseases for thousands of years. There are many animal experiments and clinical trials demonstrating that the traditional Chinese medicine such as epimedium, Drynaria and other traditional Chinese medicine can stimulate bone regeneration and inhibit bone resorption, accelerating the fracture healing. In recent years many cell experiments have shown that these herbal ingredients up-regulated the expression of intracellular osteogenic transcription factors and osteogenic related genes, and then induced osteoblastic differentiation and stimulated the proliferation of osteoblasts, bone nodule formation and matrix mineralization...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455485/-risk-factors-of-non-surgical-vertebral-fracture-after-percutaneous-kyphoplasty-of-single-segment-thoracolumbar-fracture
#8
Jian Wu, Yue-Hong Guan, Sheng-Li Fan
OBJECTIVE: To investigate the risk factors of non-surgical vertebral fracture after percutaneous kyphoplasty (PKP) in patients with single segment thoracolumbar osteoporotic vertebral compression fracture(OVCF). METHODS: The clinical data of 219 patients with single segment thoracolumbar osteoporotic vertebral compression fracture underwent percutaneous kyphoplasty from January 2010 to December 2015 were retrospectively analyzed. There were 29 cases in non-surgical vertebral body fracture group with 7 males and 22 females aged (67...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455249/multiple-vertebral-fractures-following-osteoporosis-treatment-discontinuation-a-case-report-after-long-term-odanacatib
#9
N Binkley, D Krueger, A E de Papp
INTRODUCTION: Case reports of women sustaining multiple vertebral fractures (VF) soon afterdenosumab discontinuation are accumulating. METHODS: We report a woman with five new vertebral fractures in ~8 months following discontinuation of long-term odanacatib (ODN), an experimental cathepsin K inhibitor. RESULTS: DXA examination demonstrated an ~12% decline in bone mineral density (BMD) and ~9% decline in trabecular bone score (TBS) since ODN discontinuation...
February 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29453726/advances-in-probiotic-regulation-of-bone-and-mineral-metabolism
#10
REVIEW
Laura R McCabe, Narayanan Parameswaran
Probiotics have been consumed by humans for thousands of years because they are beneficial for long-term storage of foods and promote the health of their host. Ingested probiotics reside in the gastrointestinal tract where they have many effects including modifying the microbiota composition, intestinal barrier function, and the immune system which result in systemic benefits to the host, including bone health. Probiotics benefit bone growth, density, and structure under conditions of dysbiosis, intestinal permeability, and inflammation (recognized mediators of bone loss and osteoporosis)...
February 16, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29453659/fracture-risk-in-women-with-type-ii-diabetes-results-from-a-historical-cohort-with-fracture-follow-up
#11
Jakob Præst Holm, Thomas Jensen, Lars Hyldstrup, Jens-Erik Beck Jensen
PURPOSE: To examine the independent association between type II diabetes and fracture risk in a population of predominantly postmenopausal women referred to a specialist clinic for osteoporosis evaluation. METHODS: Type II diabetes associated fracture risk were evaluated among to 229 patients with type II diabetes in a cohort of 6285 women followed on average (until major osteoporotic fracture (MOF), death or end of study) for 5.8 years. Information of fracture risk factors was obtained from a clinical database and from national registries...
February 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29452406/negative-association-between-sclerostin-and-insl3-in-isolated-human-osteocytes-and-in-klinefelter-syndrome-new-hints-for-testis-bone-crosstalk
#12
Andrea Di Nisio, Luca De Toni, Maria Santa Rocca, Marco Ghezzi, Riccardo Selice, Giuseppe Taglialavoro, Alberto Ferlin, Carlo Foresta
Context/Objective: The regulation of bone mass by the testis is a well-recognized mechanism, but the role of Leydig-specific marker insuline-like 3 peptide (INSL3) on the most abundant bone cell population, osteocytes, is unknown. In this study we aimed to investigate the relationship between INSL3 and Sclerostin, an osteocyte-specific protein that negatively regulates bone formation. Design/Setting: Serum sclerostin and INSL3 levels were evaluated in Klinefelter Syndrome (KS) and healthy controls...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29452318/bone-metabolic-markers-in-the-clinical-assessment-of-patients-with-superior-semicircular-canal-dehiscence-treated-with-middle-fossa-craniotomy
#13
Thien Nguyen, Carlito Lagman, John P Sheppard, Courtney Duong, Vera Ong, Jessica Poon, Yasmine Alkhalid, Daniel Azzam, Prasanth Romiyo, Giyarpuram N Prashant, Quinton Gopen, Isaac Yang
BACKGROUND: Superior semicircular canal dehiscence (SSCD) is a bony defect in the osseous shell of the petrous temporal bone. The pathophysiological association between osteoporosis and SSCD remains poorly understood. We aim to investigate the relationships between serum calcium, 25-hydroxyvitamin D, and thyroid stimulating hormone levels, and symptoms in adult patients with SSCD treated through a middle fossa craniotomy. METHODS: Patient demographics and clinical parameters were collected...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452286/risk-factor-analysis-of-adjacent-segment-disease-requiring-surgery-after-short-lumbar-fusion-the-influence-of-rheumatoid-arthritis
#14
Jin-Sung Park, Kyu-Dong Shim, Young-Sik Song, Ye-Soo Park
BACKGROUND CONTEXT: The influence of rheumatoid arthritis (RA) on the lumbar spine has received relatively little attention compared with cervical spine, and few studies have been conducted for adjacent segment disease (ASD) after lumbar fusion in the patients with RA. PURPOSE: To determine the incidence of ASD requiring surgery (ASDrS) after short lumbar fusion and to evaluate risk factors of ASDrS, including RA. STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: This study included 479 patients who underwent lumbar spinal fusion of 3 or fewer levels, with the mean follow-up period of 51...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29452267/git2-a-keystone-in-ageing-and-age-related-disease
#15
REVIEW
Jaana van Gastel, Jan Boddaert, Areta Jushaj, Richard T Premont, Louis M Luttrell, Jonathan Janssens, Bronwen Martin, Stuart Maudsley
Since its discovery, G protein-coupled receptor kinase-interacting protein 2, GIT2, and its family member, GIT1, have received considerable interest concerning their potential key roles in regulating multiple inter-connected physiological and pathophysiological processes. GIT2 was first identified as a multifunctional protein that is recruited to G protein-coupled receptors (GPCRs) during the process of receptor internalization. Recent findings have demonstrated that perhaps one of the most important effects of GIT2 in physiology concerns its role in controlling multiple aspects of the complex ageing process...
February 13, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29451816/effects-of-teriparatide-on-morphology-of-aortic-calcification-in-aged-hyperlipidemic-mice
#16
Jeffrey J Hsu, Jinxiu Lu, Soban Umar, Jason T Lee, Rajan Kulkarni, Yichen Ding, Chih-Chiang Chang, Tzung K Hsiai, Akishige Hokugo, Ioannis Gkouveris, Sotirios Tetradis, Ichiro Nishimura, Linda L Demer, Yin Tintut
Calcific aortic vasculopathy correlates with bone loss in osteoporosis in an age-independent manner. Prior work suggests that teriparatide, the bone anabolic treatment for postmenopausal osteoporosis, may inhibit onset of aortic calcification. Whether teriparatide affects progression of pre-existing aortic calcification, widespread among this patient population, is unknown. Female apolipoprotein E-deficient mice were aged for over one year to induce aortic calcification, treated for 4.5 weeks with daily injections of control vehicle (PBS), teriparatide 40 µg/kg (PTH40) or 400 µg/kg (PTH400), and assayed for aortic calcification by micro-computed tomography (microCT) before and after treatment...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451707/simultaneous-preparation-and-comparison-of-the-osteogenic-effects-of-epimedin-a-b-and-c-and-icariin-from-e-brevicornu
#17
Yani Guo, Xiufeng Wang, Jing Gao
In this study, epimedin A-, B- and C- and icariin-rich extracts were simultaneously prepared from Epimedium brevicornu Maxim (E. brevicornu) through a convenient four-stage process consisting of solvent extraction, macroporous resin column pre-concentration, extraction fractionation and reversed-phase (RP)-silica gel column chromatography. Single factor experiments and response surface methodology (RSM) were used to optimize the preparation conditions. In the final products, the purity of epimedin A, B and C and icariin were 23...
February 16, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29451049/the-increase-in-bone-mineral-density-by-bisphosphonate-with-active-vitamin-d-analogue-is-associated-with-the-serum-calcium-level-within-the-reference-interval-in-postmenopausal-osteoporosis
#18
Mayuko Kinoshita, Muneaki Ishijima, Haruka Kaneko, Lizu Liu, Masashi Nagao, Ryo Sadatsuki, Shinnosuke Hada, Hitoshi Arita, Takako Aoki, Makoto Yamanaka, Hidetoshi Nojiri, Yuko Sakamoto, Akifumi Tokita, Kazuo Kaneko
OBJECTIVES: To examine the factors associated with increase in lumbar spine bone mineral density (LS-BMD) by bisphosphonates (BPs) with active vitamin D analogue (aVD). METHODS: Two independent postmenopausal osteoporotic patients treated by BPs with aVD for 24 months (Study1:n = 93,Study2:n = 99) were retrospectively analyzed. RESULTS: In Study1, LS-BMD of the patients significantly increased for 24m (5.4%,p<0.001). A multiple regression analysis among baseline characteristics revealed that serum calcium (sCa:8...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29449812/calycosin-orchestrates-osteogenesis-of-danggui-buxue-tang-in-cultured-osteoblasts-evaluating-the-mechanism-of-action-by-omics-and-chemical-knock-out-methodologies
#19
Amy G W Gong, Ran Duan, Huai Y Wang, Tina T X Dong, Karl W K Tsim
Danggui Buxue Tang (DBT), an ancient Chinese herbal decoction commonly used to mitigate menopausal osteoporosis, contains two herbs: Astragali Radix (AR) and Angelicae Sinensis Radix (ASR). The exact efficacy of individual chemical(s) within DBT, or in any herbal mixture, is hard to be revealed. Calycosin and ferulic acid have been reported to be the predominant chemicals found within DBT, and its roles in regulating osteoblastic differentiation have been proposed here. To probe the roles of calycosin and ferulic acid, these chemicals were specifically depleted from the DBT extracts...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29447676/referral-patterns-to-an-osteoporosis-clinic-for-dermatology-patients-undergoing-prolonged-corticosteroid-therapy
#20
Christen Mowad, Stacy F Cohen, Nicole Flandry Fussell, R Erin Martin, Cassondra Andreychik Ellison
No abstract text is available yet for this article.
March 2018: Journal of the American Academy of Dermatology
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