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Osteoporosis

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https://www.readbyqxmd.com/read/29929041/bone-and-plasma-citrate-is-reduced-in-osteoporosis
#1
Hongdong Chen, Yeyang Wang, Huaiqian Dai, Xinggui Tian, Zhong-Kai Cui, Zhenguo Chen, Le Hu, Qiancheng Song, Anling Liu, Zhiyong Zhang, Guozhi Xiao, Jian Yang, Yu Jiang, Xiaochun Bai
High concentration of citrate exists in bone of humans and all osteo-vertebrates, and citrate incorporation imparts important biomechanical and other functional properties to bone. However, which cells are responsible for citrate production in bone remains unclear and whether the citrate component changes with bone loss during osteoporosis is also not known. Here, we show that the citrate content is markedly reduced in the bone of mice or rats with age-related, ovariectomy-induced or retinoic acid-induced bone loss...
June 18, 2018: Bone
https://www.readbyqxmd.com/read/29928929/site-specific-differences-in-osteoblast-phenotype-mechanical-loading-response-and-estrogen-receptor-related-gene-expression
#2
Borzo Gharibi, Mandeep S Ghuman, Giuseppe Cama, Simon C F Rawlinson, Agamemnon E Grigoriadis, Francis J Hughes
The osteoporosis-resistant nature of skull bones implies inherent differences exist between their cellular responses and those of other osteoporosis-susceptible skeletal sites. Phenotypic differences in calvarial and femoral osteoblastic responses to induction of osteogenesis, mechanical loading, estrogen, growth factor and cytokine stimulation were investigated. Primary rat calvarial and femoral adult male osteoblasts were cultured and osteoblastic mineralisation and maturation determined using Alizarin Red staining and expression of osteogenic marker genes assessed...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29928095/rare-case-of-atypical-femoral-fracture-with-blocked-medullary-canal-associated-with-bisphosphonate-therapy
#3
A Shetty, P Shenoy, A Bari, R Swaminathan
Bisphosphonates are widely used for treatment of osteoporosis and its use is increasing in geriatric population. Atypical femoral fractures are associated with bisphosphonate therapy. We report an unusual case of femoral shaft fracture following bisphosphonate therapy where the femoral canal of the proximal and distal fracture fragments was blocked and its management.
June 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29927952/variations-in-osteoporosis-medication-utilization-a-population-based-ecological-cross-sectional-study-in-the-region-of-valencia-spain
#4
Gabriel Sanfélix-Gimeno, María-Lirios Juliá-Sanchis, Julián Librero, Salvador Peiró, Aníbal García-Sempere
Little is known about the contextual variability in osteoporosis medication utilization. Our aims were 1) to describe variations in utilization and spending on osteoporotic medication between the Primary Care Health Zones (PHZ) of the Valencia region, Spain, 2) to analyze observed variations using Small Area Variation Analysis methods, and 3) to quantify the influence of the specialized care level on variations in utilization. We conducted a population-based cross-sectional ecological study of expenditure and utilization of five therapeutic groups marketed as osteoporosis treatments in Spain in 2009...
2018: PloS One
https://www.readbyqxmd.com/read/29926979/lactobacillus-reuteri-reduces-bone-loss-in-older-women-with-low-bone-mineral-density-a-randomized-placebo-controlled-double-blind-clinical-trial
#5
Anna G Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon
The importance of the gut microbiome for bone metabolism in mice has recently been demonstrated, but no studies are available in humans. Lactobacillus reuteri ATCCPTA 6475 (L. reuteri 6475) has been reported to increase bone mineral density (BMD) in mice but its effect on the human skeleton is unknown. The objective of this trial was to investigate if L. reuteri 6475 affects bone loss in older women with low BMD. In this double-blind, placebo-controlled study, women from the population who were 75 to 80 years old and had low BMD were randomized to orally receive 1010 colony-forming units of L...
June 21, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29926975/is-there-a-place-for-bone-turnover-markers-in-the-management-of-osteoporosis
#6
B L Langdahl
No abstract text is available yet for this article.
June 21, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29926970/parathyroid-hormone-for-bone-regeneration
#7
REVIEW
Samantha J Wojda, Seth W Donahue
Delayed healing and/or non-union occur in approximately 5-10% of the fractures that occur annually in the United States. Segmental bone loss increases the probability of non-union. Though grafting can be an effective treatment for segmental bone loss, autografting is limited for large defects since a limited amount of bone is available for harvest. Parathyroid hormone (PTH) is a key regulator of calcium homeostasis in the body and plays an important role in bone metabolism. Presently PTH is FDA approved for use as an anabolic treatment for osteoporosis...
June 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29926935/bacteria-bones-and-stones-managing-complications-of-short-bowel-syndrome
#8
REVIEW
Erika Johnson, Long Vu, Laura E Matarese
Short bowel syndrome (SBS) occurs in patients who have had extensive resection. The primary physiologic consequence is malabsorption, resulting in fluid and electrolyte abnormalities and malnutrition. Nutrient digestion, absorption, and assimilation may also be diminished by disturbances in the production of bile acids and digestive enzymes. Small bowel dilation, dysmotility, loss of ileocecal valve, and anatomical changes combined with acid suppression and antimotility drugs increase the risk of small intestinal bacterial overgrowth, further contributing to malabsorption...
June 21, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29925146/-minimally-invasive-small-incision-direct-anterior-total-hip-arthroplasty-in-the-lateral-decubitus-position-complications-and-early-outcome
#9
C Zhu, X F Shang, R Kong, K R Wu, Y M Wang, R X Ma, M Chen, Z L Luo
Objective: To analyze the feasibility, perioperative complications and early outcomes of minimally invasive small incision in direct anterior approach total hip arthroplasty in lateral decubitus position. Methods: From January 2015 to January 2017, 212 patients (228 hips) received minimally invasive small incision (approximately 8 cm in length) direct anterior approach total hip arthroplasty in modified lateral decubitus position and approach. Sixteen cases underwent bilateral hip arthroplasty separately. All procedures were performed by the same surgeon in the Department of Orthopedics, the First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital...
June 5, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29924424/identification-of-an-epigenetic-signature-of-osteoporosis-in-blood-dna-of-post-menopausal-women
#10
David Cheishvili, Surabhi Parashar, Niaz Mahmood, Ani Arakelian, Richard Kremer, David Goltzman, Moshe Szyf, Shafaat A Rabbani
Osteoporosis is one of the most common age-related progressive bone diseases in elderly people. Approximately one in three women and one in five men are predisposed to developing OP. In postmenopausal women a reduction in bone mineral density (BMD) leads to an increased risk of fractures. In the current study we delineated the DNA methylation signatures in whole blood samples of postmenopausal osteoporotic women. We obtained whole blood DNA from 22 normal women and 22 postmenopausal osteoporotic women (51-89 years) from the Canadian Multicenter Osteoporosis Study (CaMos) cohort...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29924137/strontium-ranelate-as-a-possible-disease-modifying-osteoarthritis-drug-a-systematic-review
#11
T A Rodrigues, A O Freire, B F Bonfim, M S S Cartágenes, J B S Garcia
Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA drugs have been frequently investigated but conclusive findings are rare. Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects in decreasing the risk of fractures and possible effect in reducing the progression of OA...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29923225/bone-turnover-markers-are-not-associated-with-hip-fracture-risk-a-case-control-study-in-the-women-s-health-initiative
#12
Carolyn J Crandall, Sowmya Vasan, Andrea LaCroix, Meryl S LeBoff, Jane A Cauley, John A Robbins, Rebecca D Jackson, Douglas C Bauer
Current guidelines recommend that serum C-terminal telopeptide of type I collagen (CTX) and serum procollagen type 1 aminoterminal propeptide (PINP), measured by standardized assays, be used as reference markers in observational and interventional studies. However, there are limited data to determine whether serum CTX and PINP are associated with hip fracture risk among postmenopausal women. We determined the associations of serum CTX and serum PINP with hip fracture risk among postmenopausal women aged 50 to 79 years at baseline...
June 19, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29922744/anti-nerve-growth-factor-therapy-attenuates-cutaneous-hypersensitivity-and-musculoskeletal-discomfort-in-mice-with-osteoporosis
#13
Miyako Suzuki, Magali Millecamps, Seiji Ohtori, Chisato Mori, Laura S Stone
Introduction: The prevalence of osteoporosis is increasing with the aging population and is associated with increased risk of fracture and chronic pain. Osteoporosis is currently treated with bisphosphonate therapy to attenuate bone loss. We previously reported that improvement in bone mineral density is not sufficient to reduce osteoporosis-related pain in an ovariectomy (OVX)-induced mouse model of osteoporosis, highlighting the need for new treatments. Targeting of nerve growth factor (NGF) with sequestering antibodies is a promising new direction for the treatment of musculoskeletal pain including back pain and arthritis...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922706/soy-protein-improves-tibial-whole-bone-and-tissue-level-biomechanical-properties-in-ovariectomized-and-ovary-intact-low-fit-female-rats
#14
Pamela S Hinton, Laura C Ortinau, Rebecca K Dirkes, Emily L Shaw, Matthew W Richard, Terese Z Zidon, Steven L Britton, Lauren G Koch, Victoria J Vieira-Potter
Background: Osteoporosis and related fractures, decreased physical activity, and metabolic dysfunction are serious health concerns for postmenopausal women. Soy protein might counter the negative effects of menopause on bone and metabolic health due to the additive or synergistic effects of its bioactive components. Objective: To evaluate the effects of ovariectomy (OVX) and a soy-protein diet (SOY) on bone outcomes in female, low-capacity running (LCR) rats selectively bred for low aerobic fitness as a model of menopause...
June 2018: Bone Reports
https://www.readbyqxmd.com/read/29922447/the-influence-of-age-and-osteoporosis-on-bone-marrow-stem-cells-from-rats
#15
A Sanghani-Kerai, L Osagie-Clouard, G Blunn, M Coathup
Objectives: This study aimed to assess the effect of age and osteoporosis on the proliferative and differentiating capacity of bone-marrow-derived mesenchymal stem cells (MSCs) in female rats. We also discuss the role of these factors on expression and migration of cells along the C-X-C chemokine receptor type 4 (CXCR-4) / stromal derived factor 1 (SDF-1) axis. Methods: Mesenchymal stem cells were harvested from the femora of young, adult, and osteopenic Wistar rats...
April 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29922354/-18-f-fluorocholine-positron-emission-tomography-computerised-tomography-is-useful-in-localising-99m-tc-sesta-methoxyisobutylisonitrile-negative-parathyroid-cyst-causing-normocalcemic-primary-hyperparathyroidism
#16
Deep Dutta, Pradeep Kumar Gupta, Meha Sharma, Nishikant Avinash Damble, Renu Madan, Shruti Dogra
Parathyroid cysts are extremely rare and are rarely associated with primary hyperparathyroidism (PHPT), which are difficult to localise, as they are 99m Tc-sesta-methoxyisobutylisonitrile (sestaMIBI) negative. We report for the first time the utility of 18 F-fluorocholinepositron emission tomography/computerised tomography (PC-PET/CT) in localising parathyroid cyst causing normocalcemic PHPT. A 76-year-old lady with progressively worsening osteoporosis from 2014-2017 (in spite of annual zolendronic acid infusions, daily calcium and vitamin-D supplementation) with persistently normal serum calcium and vitamin D, but elevated parathyroid hormone, had normal sestaMIBI scans of the neck on multiple occasions...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922235/association-of-vitamin-d-receptor-gene-variation-with-osteoporosis-risk-in-belarusian-and-lithuanian-postmenopausal-women
#17
Pavel M Marozik, Marija Tamulaitiene, Ema Rudenka, Vidmantas Alekna, Irma Mosse, Alena Rudenka, Volha Samokhovec, Katsiaryna Kobets
Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. VDR dysfunction might substantially contribute to development of postmenopausal osteoporosis (PMO). Numerous studies have revealed the effects of several VDR gene variants on osteoporosis risk, although significant variation in different ethnicities have been suggested. The main purpose of this work was to assess the frequency of distribution of VDR genetic variants with established effect and evaluate their haplotype association with the risk of PMO in a cohort of Belarusian and Lithuanian women...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29921799/nutritional-requirements-of-lung-transplant-recipients-challenges-and-considerations
#18
REVIEW
Valerie Jomphe, Larry C Lands, Genevieve Mailhot
An optimal nutritional status is associated with better post-transplant outcomes and survival. Post-lung transplant nutrition management is however particularly challenging as lung recipients represent a very heterogeneous group of patients in terms of age, underlying diseases, weight status and presence of comorbidities. Furthermore, the post-transplant period encompasses several stages characterized by physiological and pathophysiological changes that affect nutritional status of patients and necessitate tailored nutrition management...
June 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29921374/regulation-of-vitamin-d-receptor-and-genistein-on-bone-metabolism-in-mouse-osteoblasts-and-the-molecular-mechanism-of-osteoporosis
#19
C F Ye, Y M Pan, H Zhou
The aim of this work was to study the mechanisms of vitamin D receptor (VDR) and Genistein (Gen) on the regulation of bone metabolism of phytoestrogens from cellular and epidemiological perspectives. MC3T3-E1 cells were treated with different concentrations of Gen, and the cell-proliferation rate was detected by an MTT colorimetric assay. The effect of the VDR receptor blocker ZK159222 on the Gen effect was then observed; after adding Gen to MC3T3-E1 cells, we detected the expression of VDR protein via Western blotting...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29921194/scorpion-venom-peptides-as-a-potential-source-for-human-drug-candidates
#20
Bushra Uzair, Sarah Bint-E-Irshad, Barkat Ali Khan, Beenish Azad, Tariq Mahmood, Mujaddad Ur Rehman, Valdir A Braga
BACKGROUND: Scorpion venom is the most expensive and deadly venom with exciting medical prospects and having a potential as a source of drug candidates. A number of scorpion venom peptides have shown promising site specificity and are involved in the regulation of biological mechanisms. Due to the structural and functional specificity, the scorpion peptides are widely used for the development of specific drugs especially for the cardiovascular and other immune diseases. In this review, we summarize scorpion venom's biological activities such as antimicrobial, antiviral, anti-cancerous and in immune diseases...
June 13, 2018: Protein and Peptide Letters
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