keyword
https://read.qxmd.com/read/38532940/risk-of-bleeding-and-venous-thromboembolism-after-colorectal-cancer-surgery-in-patients-with-and-without-type-2-diabetes-a-danish-cohort-study
#21
JOURNAL ARTICLE
Frederik Pagh Bredahl Kristensen, Erzsébet Horváth-Puhó, Szimonetta Komjáthiné Szépligeti, Frederikke Schoenfeldt Troelsen, Henrik Toft Sørensen
Background  Bleeding and venous thromboembolism (VTE) are adverse outcomes after colorectal cancer (CRC) surgery. Type 2 diabetes (T2D) clusters with bleeding and VTE risk factors. We examined the bleeding and VTE risk in patients with T2D undergoing CRC surgery and the prognosis after these adverse outcomes. Methods  We conducted a prognostic population-based cohort study of 48,295 patients with and without T2D undergoing surgery for incident CRC during 2005 to 2019. Patients with T2D were diagnosed in a hospital setting or had redeemed a glucose-lowering drug prescription; the remaining cohort was patients without diabetes...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38532593/-progress-of-circulating-tumor-dna-in-the-clinical-management-of-colorectal-cancer
#22
JOURNAL ARTICLE
Z Y Jiang, W Fu
Despite the great progress in the treatment of colorectal cancer (CRC), the current standard treatment protocols still have many limitations, and there is an urgent need for more effective biomarkers for personalized patient treatment. Circulating tumor DNA (ctDNA), as a dynamic, non-invasive liquid biopsy approach, overcomes the limitations of tissue biopsy in detecting tumor heterogeneity and molecular evolution. Current evidence from several studies suggests that ctDNA shows great promise in stratifying recurrence risk, guiding treatment decisions, and monitoring early recurrence...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532587/-incidence-of-postoperative-complications-in-chinese-patients-with-gastric-or-colorectal-cancer-based-on-a-national-multicenter-prospective-cohort-study
#23
JOURNAL ARTICLE
S Q Zhang, Z Q Wu, B W Huo, H N Xu, K Zhao, C Q Jing, F L Liu, J Yu, Z R Li, J Zhang, L Zang, H K Hao, C H Zheng, Y Li, L Fan, H Huang, P Liang, B Wu, J M Zhu, Z J Niu, L H Zhu, W Song, J You, S Yan, Z Y Li
Objective: To investigate the incidence of postoperative complications in Chinese patients with gastric or colorectal cancer, and to evaluate the risk factors for postoperative complications. Methods: This was a national, multicenter, prospective, registry-based, cohort study of data obtained from the database of the Prevalence of Abdominal Complications After Gastro- enterological Surgery (PACAGE) study sponsored by the China Gastrointestinal Cancer Surgical Union. The PACAGE database prospectively collected general demographic characteristics, protocols for perioperative treatment, and variables associated with postoperative complications in patients treated for gastric or colorectal cancer in 20 medical centers from December 2018 to December 2020...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532520/habitat-based-radiomics-analysis-for-evaluating-immediate-response-in-colorectal-cancer-lung-metastases-treated-by-radiofrequency-ablation
#24
JOURNAL ARTICLE
Haozhe Huang, Hong Chen, Dezhong Zheng, Chao Chen, Ying Wang, Lichao Xu, Yaohui Wang, Xinhong He, Yuanyuan Yang, Wentao Li
PURPOSE: To create radiomics signatures based on habitat to assess the instant response in lung metastases of colorectal cancer (CRC) after radiofrequency ablation (RFA). METHODS: Between August 2016 and June 2019, we retrospectively included 515 lung metastases in 233 CRC patients who received RFA (412 in the training group and 103 in the test group). Multivariable analysis was performed to identify independent risk factors for developing the clinical model. Tumor and ablation regions of interest (ROI) were split into three spatial habitats through K-means clustering and dilated with 5 mm and 10 mm thicknesses...
March 26, 2024: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://read.qxmd.com/read/38532470/tumoricidal-properties-of-thymoquinone-on-human-colorectal-adenocarcinoma-cells-via-the-modulation-of-autophagy
#25
JOURNAL ARTICLE
Mohammad Saleh Moulana, Sanya Haiaty, Ahad Bazmani, Roya Shabkhizan, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Mostafa Mostafazadeh, Mohammad Reza Asadi, Mehdi Talebi, Zahra Jafari, Mohammad Reza Morovati, Mohammad Hosein Farzaei, Reza Rahbarghazi
Colorectal cancer (CRC) is deadly anaplastic changes in the gastrointestinal tract with high-rate mortality. In recent years, the application of phytocompounds has been extended along with different therapeutic protocols. Here, we monitored the effects of Thymoquinone (TQ) on autophagy via mitochondrial function after modulation of the Wnt/β-catenin signaling pathway.Human colorectal adenocarcinoma HT-29 cells were treated with TQ (60 µM) and 15 µM Wnt3a inhibitor (LGK974) for 48 h. The survival rate was evaluated using an MTT assay...
March 26, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38532280/procalcitonin-and-c-reactive-protein-as-early-markers-of-anastomotic-leakage-in-intestinal-resections-for-advanced-ovarian-cancer-edmocs
#26
JOURNAL ARTICLE
José Luis Sánchez-Iglesias, Clara Morales-Coma, Lucas Minig, Víctor Lago, Santiago Domingo, Gemma Mancebo, Jaime Siegrist, María Soledad Fidalgo García, Antoni Llueca, Anna Serra, Paloma Cobas Lozano, Arantza Lekuona Artola, Natalia R Gómez-Hidalgo, Úrsula Acosta, Roser Ferrer-Costa, Melissa Bradbury, Assumpció Pérez-Benavente, Antonio Gil-Moreno
INTRODUCTION: Serum levels of procalcitonin and C-reactive protein (CRP) have been used to predict anastomotic leakage after colorectal surgery, but information is scarce in advanced ovarian cancer (AOC) surgery with bowel resection. This study aimed to assess the predictive value of procalcitonin and CRP in detecting anastomotic leakage after AOC surgery with bowel resection. The study also aimed to determine the optimal postoperative reference values and the best day for evaluating these markers...
March 26, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38532153/dynamic-treatment-strategy-of-chinese-medicine-for-metastatic-colorectal-cancer-based-on-machine-learning-algorithm
#27
JOURNAL ARTICLE
Yu-Ying Xu, Qiu-Yan Li, Dan-Hui Yi, Yue Chen, Jia-Wei Zhai, Tong Zhang, Ling-Yun Sun, Yu-Fei Yang
OBJECTIVE: To establish the dynamic treatment strategy of Chinese medicine (CM) for metastatic colorectal cancer (mCRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment strategies for mCRC. METHODS: From the outpatient cases of mCRC in the Department of Oncology at Xiyuan Hospital, China Academy of Chinese Medical Sciences, 197 cases that met the inclusion criteria were screened. According to different CM intervention strategies, the patients were divided into 3 groups: CM treatment alone, equal emphasis on Chinese and Western medicine treatment (CM combined with local treatment of tumors, oral chemotherapy, or targeted drugs), and CM assisted Western medicine treatment (CM combined with intravenous regimen of Western medicine)...
March 27, 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38532110/the-c-type-lectin-dcir-contributes-to-the-immune-response-and-pathogenesis-of-colorectal-cancer
#28
JOURNAL ARTICLE
Giulia Trimaglio, Tamara Sneperger, Benjamin B A Raymond, Nelly Gilles, Emmanuelle Näser, Marie Locard-Paulet, Marieke E Ijsselsteijn, Thomas P Brouwer, Romain Ecalard, Jessica Roelands, Naoki Matsumoto, André Colom, Myriam Habch, Noel F C C de Miranda, Nathalie Vergnolle, Christel Devaud, Olivier Neyrolles, Yoann Rombouts
Development and progression of malignancies are accompanied and influenced by alterations in the surrounding immune microenvironment. Understanding the cellular and molecular interactions between immune cells and cancer cells has not only provided important fundamental insights into the disease, but has also led to the development of new immunotherapies. The C-type lectin Dendritic Cell ImmunoReceptor (DCIR) is primarily expressed by myeloid cells and is an important regulator of immune homeostasis, as demonstrated in various autoimmune, infectious and inflammatory contexts...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38532103/identification-of-unique-rectal-cancer-specific-subtypes
#29
JOURNAL ARTICLE
Batuhan Kisakol, Anna Matveeva, Manuela Salvucci, Alexander Kel, Elizabeth McDonough, Fiona Ginty, Daniel B Longley, Jochen H M Prehn
BACKGROUND: Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in expression profiles between colon and rectal tissues. Moreover, locally advanced rectal cancers at resection often have received neoadjuvant chemoradiotherapy which likely has a significant impact on gene expression. METHODS: We collected mRNA expression profiles for rectal and colon cancer samples (n = 2121). We observed that (i) Consensus Molecular Subtyping (CMS) had a different prognosis in treatment-naïve rectal vs...
March 26, 2024: British Journal of Cancer
https://read.qxmd.com/read/38531974/exploring-the-potential-of-ziziphus-nummularia-and-luteolin-7-o-glucoside-as-tubulin-inhibitors-in-cancer-therapy-and-survival
#30
JOURNAL ARTICLE
Sahar Saleh Alghamdi, Sara Abdulaziz Alghashem, Rizwan Ali, Arwa Alsubait, Rasha Saad Suliman, Afrah E Mohammed, Zeyad Alehaideb, Raghad Abdullah Alshafi, Allulu Yousef Alturki, Ishrat Rahman
Cancer is responsible for approximately 10 million deaths worldwide, with 70% of the deaths occurring in low- and middle-income countries; as such safer and more effective anti-cancer drugs are required. Therefore, the potential benefits of Ziziphus nummularia and Ziziphus spina-christi as sources of anti-cancer agents were investigated. Z. nummularia and Z. spina-christi extracts were prepared using chloroform, ethanol, ethyl acetate, and water. The extracts' anti-cancer properties were determined using the MTT Cell Viability Assay in four cancer cell lines: breast (KAIMRC2 and MDA-MB-231), colorectal (HCT8), and liver (HepG2)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531903/cancer-incidence-trends-in-new-york-state-and-associations-with-common-population-level-exposures-2010-2018-an-ecological-study
#31
JOURNAL ARTICLE
Haokun Yuan, Rebecca D Kehm, Josephine M Daaboul, Susan E Lloyd, Jasmine A McDonald, Lina Mu, Parisa Tehranifar, Kai Zhang, Mary Beth Terry, Wan Yang
The impact of common environmental exposures in combinations with socioeconomic and lifestyle factors on cancer development, particularly for young adults, remains understudied. Here, we leveraged environmental and cancer incidence data collected in New York State at the county level to examine the association between 31 exposures and 10 common cancers (i.e., lung and bronchus, thyroid, colorectal, kidney and renal pelvis, melanoma, non-Hodgkin lymphoma, and leukemia for both sexes; corpus uteri and female breast cancer; prostate cancer), for three age groups (25-49, 50-69, and 70-84 year-olds)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531808/implementable-assay-for-monitoring-minimum-residual-disease-after-radical-treatment-for-colorectal-cancer
#32
JOURNAL ARTICLE
Takafumi Nakano, Seiichiro Takao, Katsushi Dairaku, Naoki Uno, Siew-Kee Amanda Low, Masahiro Hashimoto, Yasuo Tsuda, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Ken Eto, Toru Ikegami, Yosuke Fukunaga, Atsushi Niida, Satoshi Nagayama, Koshi Mimori
Considering the cost and invasiveness of monitoring postoperative minimal residual disease (MRD) of colorectal cancer (CRC) after adjuvant chemoradiotherapy (ACT), we developed a favorable approach based on methylated circulating tumor DNA to detect MRD after radical resection. Analyzing the public database, we identified the methylated promoter regions of the genes FGD5, GPC6, and MSC. Using digital polymerase chain reaction (dPCR), we termed the "amplicon of methylated sites using a specific enzyme" assay as "AMUSE...
March 26, 2024: Cancer Science
https://read.qxmd.com/read/38531626/extent-of-investigation-and-management-of-cases-of-unexplained-mismatch-repair-deficiency-u-dmmr-a-uk-cancer-genetics-group-consensus
#33
JOURNAL ARTICLE
Terri Patricia McVeigh, Kevin J Monahan, Joseph Christopher, Nick West, Malcolm Scott, Jennie Murray, Helen Hanson
BACKGROUND: Mismatch repair deficiency (dMMR) is a characteristic feature of cancers linked to Lynch syndrome. However, in most cases, it results from sporadic somatic events rather than hereditary factors. The term 'Lynch-like syndrome' (LLS) has been used to guide colorectal cancer surveillance for relatives of individuals with a dMMR tumour when somatic and germline genomic testing is uninformative. As the assessment of mismatch repair through immunohistochemistry and/or microsatellite instability is increasingly applied across various tumour types for treatment planning, dMMR is increasingly detected in tumours where suspicion of hereditary aetiology is low...
March 26, 2024: Journal of Medical Genetics
https://read.qxmd.com/read/38531576/efficacy-and-safety-of-natural-killer-cells-injection-combined-with-xelox-chemotherapy-in-postoperative-patients-with-stage-iii-colorectal-cancer-in-china-a-prospective-randomised-controlled-clinical-trial-study-protocol
#34
JOURNAL ARTICLE
Shan Geng, Xingrui Yu, Shaohong Yu
BACKGROUND: Colorectal cancer (CRC) is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in China. However, resistance to multiple chemotherapeutics after surgery leads to failure of the main therapy to CRC. Natural killer (NK) cells are innate cytotoxic lymphocytes that exhibit strong cytotoxic activity against tumour cells. NK cell-based therapy, either alone or in combination with chemotherapy, has achieved favourable results and holds promise for addressing recurrence and metastasis in CRC patients after surgery...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#35
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38531339/molecular-pathways-of-colorectal-cancer-development-mechanisms-of-action-and-evolution-of-main-systemic-therapy-compounds
#36
REVIEW
Chiara Pierantoni, Lorenzo Cosentino, Luigi Ricciardiello
Colorectal cancer is known as one of the "big killers" in oncology given its burden in terms on morbidity and mortality. Since the second half of the last century, similarly to what happened for other solid tumors, a large series of cytotoxic molecules have been developed and tested to treat this disease. Following new discoveries in terms of colorectal cancer pathogenesis and specific pathways involved such as angiogenesis, a new series of drugs have been developed: targeted therapies. In this review we will briefly describe colorectal cancer molecular biology and its main pathways in order to retrace the main stages of oncological treatment development for colorectal cancer from the first available treatments to novel approaches to the disease...
March 26, 2024: Digestive Diseases
https://read.qxmd.com/read/38531223/extracellular-volume-fraction-can-predict-the-treatment-response-and-survival-outcome-of-colorectal-cancer-liver-metastases
#37
JOURNAL ARTICLE
Shenglin Li, Xinmei Yang, Ting Lu, Long Yuan, Yuting Zhang, Jun Zhao, Juan Deng, Caiqiang Xue, Qiu Sun, Xianwang Liu, Wenjuan Zhang, Junlin Zhou
OBJECTIVE: To assess the prognostic value of pre- and post-therapeutic changes in extracellular volume (ECV) fraction of liver metastases (LMs) for treatment response (TR) and survival outcomes in colorectal cancer liver metastases (CRLM). METHODS: 186 LMs were confirmed by pathology or follow-up (Training: 130; Test: 56). We analyzed the changes in ECV fraction of LMs before and after 2 cycles of chemotherapy combined with bevacizumab. After 12 cycles, we evaluated the TR on LMs based on the RECIST v1...
March 25, 2024: European Journal of Radiology
https://read.qxmd.com/read/38531046/experience-with-laparoscopic-and-robotic-colon-surgery-together-with-other-major-minimally-invasive-procedures-for-unrelated-pathologies
#38
JOURNAL ARTICLE
Hugo J R Bonatti
Background: Indications for combined colon surgery together with other procedures include oncologic multivisceral resections and abdominal trauma. It is unclear if combining minimally invasive (MI) colon surgery with unrelated other procedures increases the risk for complications. Patients and Methods: The surgical database from two institutions during a 10-year period was queried for combined colon surgeries together with other interventions. All open cases, combined cases performed for one pathology and MI colectomies together with a minor procedure, were excluded...
March 27, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38530611/evaluation-of-the-prognostic-performance-of-different-cutoff-values-of-lymph-node-ratio-staging-system-for-stage-iii-colorectal-cancer
#39
JOURNAL ARTICLE
Yimin E, Chen Lu, Zijun Wang, Yicheng Huang, Pengcheng Ji, Xiagang Luo, Chaoshun Chu, Chunzhao Yu
This study attempted to compare the prognostic performance of lymph node ratio (LNR) staging system with different cutoff values relative to American Joint Committee on Cancer (AJCC) pN staging system in stage III colorectal cancer (CRC). Overall, 45,069 patients from the SEER dataset and 69 patients from the Second Affiliated Hospital of Nanjing Medical University (the External set) who underwent surgical resection of the primary tumor and were diagnosed with stage III CRC by postoperative pathology were included...
March 26, 2024: Updates in Surgery
https://read.qxmd.com/read/38530597/pd-l1-expression-in-colorectal-carcinoma-correlates-with-the-immune-microenvironment
#40
JOURNAL ARTICLE
Mohammed Shahin, Susama Patra, Suvendu Purkait, Madhabananda Kar, Saroj Kumar Das Majumdar, Tushar Subhadarshan Mishra, Subash Chandra Samal, Hemanta Kumar Nayak
INTRODUCTION/BACKGROUND: Colorectal carcinoma (CRC) is a common malignancy, with its diverse clinical, pathological, and molecular features. The immune microenvironment of a tumor comprises of interplay between various cells and molecules, and has a significant role in deciding the tumor behavior and overall prognosis. PD-L1 (programmed cell death ligand-1) has been implicated in the regulation of the tumor immune microenvironment (TIME). There is limited data regarding the correlation of PD-L1 expression with immune cell profile in CRCs, especially in the Indian setting...
March 26, 2024: Journal of Gastrointestinal Cancer
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