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https://www.readbyqxmd.com/read/27930276/unicentric-castlemans-disease-masquerading-as-a-carcinoid-tumor-of-the-small-intestine
#1
Warqaa Akram, John Degliuomini, Marc K Wallack, Shan Huang, Enyioma Okechukwu, Tam Eric
No abstract text is available yet for this article.
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27922538/the-role-of-68ga-dota-noc-pet-ct-in-evaluating-neuroendocrine-tumors-real-world-experience-from-two-large-neuroendocrine-tumor-centers
#2
Mohamad Haidar, Ali Shamseddine, Emmanouil Panagiotidis, Mario Jreige, Deborah Mukherji, Rita Assi, Rayan Abousaid, Toni Ibrahim, Marwan M Haddad, Sobhan Vinjamuri
OBJECTIVE: Our aim was to assess the role of Ga-DOTA-NOC PET/CT as a tool for the management of neuroendocrine tumors (NETs), evaluating the clinical impact on patients from two large NET centers in different geopolitical settings. PATIENTS AND METHODS: This is a retrospective study of patients with NETs who underwent Ga-DOTA-NOC PET/CT at Royal Liverpool University Hospital (UK) and at Mount Lebanon Hospital (Lebanon). Indications for imaging and findings of the PET/CT along with demographic and clinical outcome data were recorded and evaluated...
December 2, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27922277/goblet-cell-carcinoid-of-the-ovary-a-case-report-with-ultrastructural-analysis
#3
Maria G Fiore, Roberta Rossi, Claudia Covelli, Vera Loizzi, Domenico Piscitelli, Gennaro Cormio
No abstract text is available yet for this article.
December 6, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27920648/synchronous-adenocarcinoma-of-the-colon-and-rectal-carcinoid
#4
Vamshidhar Vootla, Rafeeq Ahmed, Masooma Niazi, Bhavna Balar, Suresh Nayudu
Primary colonic adenocarcinoma and synchronous rectal carcinoids are rare tumors. Whenever a synchronous tumor with a nonmetastatic carcinoid component is encountered, its prognosis is determined by the associate malignancy. The discovery of an asymptomatic gastrointestinal carcinoid during the operative treatment of another malignancy will usually only require resection without additional treatment and will have little effect on the prognosis of the individual. This article reports a synchronous rectal carcinoid in a patient with hepatic flexure adenocarcinoma...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27918724/telotristat-ethyl-a-tryptophan-hydroxylase-inhibitor-for-the-treatment-of-carcinoid-syndrome
#5
Matthew H Kulke, Dieter Hörsch, Martyn E Caplin, Lowell B Anthony, Emily Bergsland, Kjell Öberg, Staffan Welin, Richard R P Warner, Catherine Lombard-Bohas, Pamela L Kunz, Enrique Grande, Juan W Valle, Douglas Fleming, Pablo Lapuerta, Phillip Banks, Shanna Jackson, Brian Zambrowicz, Arthur T Sands, Marianne Pavel
Purpose Preliminary studies suggested that telotristat ethyl, a tryptophan hydroxylase inhibitor, reduces bowel movement (BM) frequency in patients with carcinoid syndrome. This placebo-controlled phase III study evaluated telotristat ethyl in this setting. Patients and Methods Patients (N = 135) experiencing four or more BMs per day despite stable-dose somatostatin analog therapy received (1:1:1) placebo, telotristat ethyl 250 mg, or telotristat ethyl 500 mg three times per day orally during a 12-week double-blind treatment period...
October 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27917852/results-of-bronchoscopic-excision-in-typical-carcinoid-tumors-of-the-lung-in-turkey
#6
Hilal Boyacı, Mustafa Çörtük, Şule Gül, Elif Tanrıverdi, Mehmet Akif Özgül, Hüseyin Erhan Dinçer, Erdoğan Çetinkaya
Aim Carcinoid tumors of the lung are the tumors originating from the neuroendocrine cells. Surgical excision remains the gold standard for the treatment. Treatment with interventional bronchoscopic excision has also been reported as an alternative option in typical carcinoid tumors of the lung. The aim of this study was to present results and outcomes in patients who were bronchoscopically treated and followed-up. Methods Data of 14 patients, who had undergone bronchoscopic excision due to typical carcinoid tumor of the lung between April 2008 and July 2015 were retrospectively evaluated...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/27907837/metastatic-carcinoid-tumor-to-the-breast-report-of-two-cases-and-review-of-the-literature
#7
Shimwoo Lee, Pascale Levine, Samantha L Heller, Osvaldo Hernandez, Cecilia L Mercado, Chloe M Chhor
The breast is an unusual site for carcinoid metastasis. Due to increasing survival rates for carcinoid tumors, however, awareness of their rare complications is important. Carcinoid metastasis to the breast typically presents as a palpable breast mass or a mass on screening mammogram. Because imaging findings are nonspecific, the diagnosis is established through histological findings of neuroendocrine features corresponding with the known primary carcinoid pathology. Correctly distinguishing metastatic carcinoid from primary breast carcinoma is crucial to avoid more invasive procedures required for the latter...
October 17, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27895950/endobronchial-carcinoid-and-concurrent-carcinoid-syndrome-in-an-adolescent-female
#8
Jonathan D Cogen, Jonathan Swanson, Thida Ong
Endobronchial carcinoid tumors are the most common intrabronchial tumors in children and adolescents. Common signs and symptoms include persistent cough and wheezing not responsive to bronchodilators, hemoptysis, and recurrent fever. Diagnosis is frequently made by imaging and direct visualization with flexible bronchoscopy; surgery remains the gold standard treatment, and lung-sparing resections should be performed whenever possible. Though carcinoid syndrome-characterized by flushing, palpitations, wheezing, shortness of breath, and diarrhea-has been found in association with adult bronchial carcinoid tumors, to our knowledge only one previous study has reported the presence of carcinoid syndrome in a pediatric patient with an endobronchial carcinoid...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27890494/neuroendocrine-tumors-of-the-lung-current-challenges-and-advances-in-the-diagnosis-and-management-of-well-differentiated-disease
#9
REVIEW
Andrew E Hendifar, Alberto M Marchevsky, Richard Tuli
Neuroendocrine tumors (NET) comprise a heterogeneous group of malignancies that arise from neuroendocrine cells throughout the body, most commonly originating from the lungs and gastrointestinal tract. Lung NET can be classified as well-differentiated (low-grade typical carcinoids [TC] and intermediate-grade atypical carcinoids [AC]) and poorly differentiated (high-grade large cell neuroendocrine carcinoma or small cell lung carcinoma). The incidence of these tumors is increasing, but disease awareness remains low among thoracic specialists who are often involved in the diagnosis and early treatment for these patients...
November 23, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27879513/high-grade-neuroendocrine-carcinoma-of-the-lung-with-carcinoid-morphology-a-study-of-12-cases
#10
Anne Marie Quinn, Anshuman Chaturvedi, Daisuke Nonaka
Twelve lung neuroendocrine tumors with morphologic features of carcinoid tumors but with mitotic count >10/2 mm are reported. There were 7 males and 5 females, with age ranging from 56 to 78 years. Four cases were from never-smokers. All tumors showed architectural and cytomorphologic features of carcinoid tumor, including organoid nesting, insular, trabecular, or acinar growth, and tumor cells with low nucleocytoplasmic ratio, abundant cytoplasm, ovoid to round nuclei, and salt and pepper chromatin. Angulated or confluent nesting, insular or lobular growth pattern was also seen...
December 1, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27876462/expression-and-clinicopathological-significance-of-s100-calcium-binding-protein-a2-in-lung-cancer-patients-of-chinese-han-ethnicity
#11
Ting Wang, Yiqian Liang, Asmitananda Thakur, Shuo Zhang, Feng Liu, Hamadhaider Khan, Puyu Shi, Ning Wang, Mingwei Chen, Hui Ren
BACKGROUND: S100 family of calcium-binding proteins plays a significant role in the process of many kinds of tumors, including lung cancer. As an important member of this family, S100 calcium binding protein A2 (S100A2) has been confirmed to be associated with many biological processes, and has an abnormal expression in non-small cell lung cancer (NSCLC). However, the S100A2 status in lung cancer is still controversial and undefined. METHODS: We evaluated the pattern and distribution of S100A2 in 109 cases of lung cancer, including five histological types (47 adenocarcinoma, 46 squamous cell carcinoma, 7 small cell carcinoma, 3 large cell carcinoma, and 6 atypical carcinoid), and 30 cases of paired adjacent normal lung tissues by means of immunohistochemistry...
November 19, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27873319/lung-neuroendocrine-tumours-deep-sequencing-of-the-four-who-histotypes-reveals-chromatin-remodelling-genes-as-major-players-and-a-prognostic-role-for-tert-rb1-men1-and-kmt2d
#12
Michele Simbolo, Andrea Mafficini, Katarzyna O Sikora, Matteo Fassan, Stefano Barbi, Vincenzo Corbo, Luca Mastracci, Borislav Rusev, Federica Grillo, Caterina Vicentini, Roberto Ferrara, Sara Pilotto, Federico Davini, Giuseppe Pelosi, Rita T Lawlor, Marco Chilosi, Giampaolo Tortora, Emilio Bria, Gabriella Fontanini, Marco Volante, Aldo Scarpa
Next-generation sequencing (NGS) was applied to 148 lung neuroendocrine tumours (LNET) comprising the 4 WHO classification categories: 53 typical carcinoid (TC), 35 atypical carcinoid (AC), 27 large cell neuroendocrine carcinoma (LCNEC), and 33 small cell lung carcinoma (SCLC). A discovery screen was conducted on 46 samples using whole-exome sequencing and high-coverage targeted sequencing of 418 genes. Eighty-eight recurrently mutated genes from both the discovery screen and current literature were verified in the 46 cases of the discovery screen and validated on additional 102 LNET by targeted NGS, and their prevalence was evaluated on the whole series...
November 22, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27873160/prognostic-significance-of-cd44-and-orthopedia-homeobox-protein-otp-expression-in-pulmonary-carcinoid-tumours
#13
George Papaxoinis, Daisuke Nonaka, Ciara O'Brien, Benjamin Sanderson, Piotr Krysiak, Wasat Mansoor
CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. The scope of the present study was to validate their role in PC patients and investigate potential application in clinical practice. Data was collected from patients presenting to a tertiary cancer centre diagnosed with PC between 2003 and 2015. Diagnosis was confirmed by central pathology review. Formalin-fixed paraffin-embedded (FFPE) tissue samples collected at diagnosis were scored using immunohistochemistry (H score) for standard CD44 and nuclear and cytoplasmic OTP protein expression...
November 21, 2016: Endocrine Pathology
https://www.readbyqxmd.com/read/27873108/flushing-in-neuro-endocrinology
#14
REVIEW
Fady Hannah-Shmouni, Constantine A Stratakis, Christian A Koch
Cutaneous flushing is a common presenting complaint in endocrine disorders. The pathophysiology of flushing involves changes in cutaneous blood flow triggered by multiple intrinsic factors that are either related to physiology or disease. Flushing can be divided into episodic or persistent causes. Episodic flushing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing results in a fixed facial erythema with telangiectasia and cyanosis due to slow-flowing deoxygenated blood in large cutaneous blood vessels...
November 21, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27866458/a-virilising-primary-mucinous-carcinoid-tumour-of-the-ovary-in-a-postmenopausal-woman-a-diagnostic-challenge
#15
Jothi Doraiswamy, Kalpana Reddy, Priti A Joshi, Robert Gornall
No abstract text is available yet for this article.
November 21, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27861745/clinical-signs-of-fibrosis-in-small-intestinal-neuroendocrine-tumours
#16
K Daskalakis, A Karakatsanis, P Stålberg, O Norlén, P Hellman
BACKGROUND: In patients with small intestinal neuroendocrine tumours (SI-NETs), serotonin and other cytokines released from tumour cells may induce fibrosis, leading to carcinoid heart disease and abdominal fibrotic reactions. The aim of this study was to assess the prevalence, clinical complications and management of this reaction in the abdomen. METHODS: This was a retrospective cohort study of patients with SI-NETs diagnosed between 1985 and 2015. Clinical data, outcomes, radiological findings, and surgical and radiological interventions were reviewed...
November 10, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27857269/neuroendocrine-tumors-and-lanreotide-depot-clinical-considerations-and-nurse-and-patient-preferences
#17
Pamela Ryan, Alexandria T Phan, Daphne T Adelman, Michiko Iwasaki
BACKGROUND: Somatostatin analogs (SSAs) are a mainstay therapy for the treatment of carcinoid syndrome associated with neuroendocrine tumors (NETs). They are effective for a range of gastroenteropancreatic NETs (GEP-NETs). Lanreotide depot (Somatuline®) is an SSA that is approved for the treatment of GEP-NETs to improve progression-free survival (PFS). OBJECTIVES: The article reviews the efficacy, safety, and administration of lanreotide depot and relates those attributes to considerations and preferences of oncology nurses and their patients...
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27853738/pedunculated-gastric-neuroendocrine-tumor-a-case-report
#18
Kenichi Takeda, Shin-Ei Kudo, Fumio Ishida
Background and study aims: Gastric neuroendocrine tumors (NETs) are rare lesions that develop from neuroendocrine cells. NETs are classified into 3 types based on the rate of mitosis and Ki-67 labeling index; the NET G1 type is synonymously referred to as carcinoid. Gastric NETs are usually discovered as submucosal tumors during upper gastrointestinal endoscopic examination. This study reports a rare case of pedunculated gastric NET. The lesion was found as a result of gastroendoscopy. The gastric lesion was a pedunculated polyp with a reddish head...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27852542/factors-associated-with-elevated-serum-chromogranin-a-levels-in-patients-with-autoimmune-gastritis
#19
Çağdaş Kalkan, Fatih Karakaya, İrfan Soykan
BACKGROUND/AIMS: Chromogranin A is an important tool in the diagnosis of neuroendocrine tumors. Autoimmune gastritis is an autoimmune disorder marked by hypergastrinemia, which stimulates enterochromaffin-like cell proliferation. Chromogranin A is also elevated in autoimmune gastritis patients with a different level of increase in each patient. The goal of this study is to explore constituents that influence serum chromogranin A levels in autoimmune gastritis patients. MATERIALS AND METHODS: One hundred and eighty-eight autoimmune gastritis patients and 20 patients with type I gastric carcinoid tumors were analyzed retrospectively and compared to 110 functional dyspepsia patients in terms of factors that might affect serum chromogranin A levels...
November 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27848218/evaluation-of-diagnostic-and-prognostic-significance-of-ki-67-index-in-pulmonary-carcinoid-tumours
#20
V Clay, G Papaxoinis, B Sanderson, J W Valle, M Howell, A Lamarca, P Krysiak, P Bishop, D Nonaka, W Mansoor
BACKGROUND: Pulmonary carcinoid (PC) tumours are classified as either typical (TC) or atypical (AC) according to mitotic index (MI) and presence of necrosis. The aim of this study was to analyse the diagnostic and prognostic values of the Ki-67 index in PC. METHODS/PATIENTS: Between January 2001 and March 2015, we evaluated 94 consecutive patients with a confirmed diagnosis of TC (n = 75) or AC (n = 19) at our institution. Diagnostic histology was centrally reviewed by a local expert neuroendocrine pathologist, with assessment of Ki-67, MI, and necrosis...
November 15, 2016: Clinical & Translational Oncology
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