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https://www.readbyqxmd.com/read/28428105/microcarcinoid-arising-in-patients-with-long-standing-ulcerative-colitis-histological-analysis
#1
Sachie Kanada, Akira Sugita, Tetuo Mikami, Kenichi Ohashi, Hiroyuki Hayashi
Some case reports of neuroendocrine tumors (NETs) and neuroendocrine carcinoma (NEC) associated with ulcerative colitis (UC) have been published. Most NET cases are small lesions corresponding to microcarcinoids (MCs). However, published case reports have presented findings of MCs as single-case reports. Thus, the frequency of MCs is still unclear. In this study, we described the clinical and morphological features of 14 cases of UC-associated MC and estimated the frequency of MC. Consecutive patients with UC who underwent complete removal of the large intestine were assessed, and 135 patients were selected...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28422824/pancreatic-carcinoids-serotonin-producing-pancreatic-neuroendocrine-neoplasms-report-of-5-cases-and-review-of-the-literature
#2
Nikolaos Tsoukalas, Eleftherios Chatzellis, Dimitra Rontogianni, Krystallenia I Alexandraki, Georgios Boutzios, Anna Angelousi, Gregory Kaltsas
INTRODUCTION: Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare tumors representing 1% to 2% of all pancreatic neoplasms. These tumors can secrete a variety of biologically active substances giving rise to distinct clinical symptoms or can be clinically nonfunctioning. Apart from insulinomas and gastrinomas, which constitute the majority of functioning pNENs, some tumors may secrete serotonin presenting with the features of the carcinoid syndrome. These so-called pancreatic carcinoids are considered relatively rare tumors and are associated with increased urinary levels of 5-hydroxyindoleacetic acid (5-HIAA)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421155/an-appendiceal-carcinoid-tumor-within-an-amyand-s-hernia-mimicking-an-incarcerated-inguinal-hernia
#3
Gregorios Christodoulidis, Konstantinos Perivoliotis, Alexandros Diamantis, Dionysios Dimas, Michael Spyridakis, Konstantinos Tepetes
Introduction. We report the case of an appendiceal carcinoid tumor within an Amyand's hernia, presenting as an incarcerated right inguinal hernia. Presentation of Case. A 52-year-old male presented in the emergency department due to a persistent right inguinal pain. Clinical examination revealed a tender right groin mass. Laboratory tests revealed leukocytosis and an increased serum CRP. Under the diagnosis of an incarcerated right inguinal hernia, an emergency operation was taken. Intraoperatively, an inflamed appendix and a part of the cecum were found in the hernia sac...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28419205/comparison-of-clinical-features-and-survival-between-thymic-carcinoma-and-thymic-carcinoid-patients
#4
Yang Zhao, Haiyong Gu, Limin Fan, Ke Han, Jun Yang, Heng Zhao
OBJECTIVES: Thymic carcinoma (TC) and thymic carcinoid (TCD) are aggressive thymic epithelial neoplasms with a poor prognosis. Due to rarity, little is known about their comparative clinical characteristics, treatment outcomes and patterns of relapse. METHODS: A retrospective cohort study was performed on 287 patients with TC and 56 patients with TCD who were treated at the Shanghai Chest Hospital between February 2003 and April 2014. Patient demographics, tumour stage, treatment, pathologic findings and postoperative outcomes were compared between the two tumour types using both multivariable Cox regression analysis and propensity-matched analysis...
April 17, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28417484/well-differentiated-neuroendocrine-tumors-in-skin-terminology-and-diagnostic-utility-of-cytokeratin-5-6-and-p63
#5
Gauri Panse, Shawn E Cowper, David J Leffell, Melissa Pulitzer, Christine J Ko
BACKGROUND: Well-differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5/6 (CK 5/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK 5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28417065/progressive-dyspnea-due-to-pulmonary-carcinoid-tumorlets
#6
Anastasios Kallianos, Lemonia Velentza, Paul Zarogoulidis, Sofia Baka, Christoforos Kosmidis, Sofia Labaki, George Lazaridis, Haidong Huang, Wolfgang Hohenforst-Schmidt, Georgia Trakada
This is a case description of a female patient, 77 years-old, who presented with progressive dyspnea and cough. She had a mild hypoxemia in the arterial blood gases (PaO2 72 mmHg) and normal spirometry. The chest computer tomography revealed diffuse "ground glass" opacities, segmental alveolitis, bronchiectasis, fibrotic lesions and numerous micronodules. A thoracoscopy was performed and the obtained biopsy showed carcinoid tumorlets, with positive CK8/18, CD56, TTF-1 and synaptophysin immunohistochemical markers...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28415161/lymphoid-follicular-proctitis-resembling-rectal-carcinoid-tumor-confirmed-by-endoscopic-resection
#7
Seungjun Gim, Kang Nyeong Lee, Donghoon Lee, Hye Young Lee, Ki Sul Chang, Oh Young Lee, Ho Soon Choi
No abstract text is available yet for this article.
April 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28413786/surgical-management-of-bronchopulmonary-carcinoids-a-single-center-experience
#8
Ashish Jakhetiya, Pankaj Kumar Garg, Rambha Pandey, Palaniappan Ramanathan, Sunil Kumar, Debojit Nath, Durgatosh Pandey
INTRODUCTION: Bronchopulmonary carcinoids are uncommon tumors with relatively indolent biological behavior but a distinct malignant potential. Surgery is the mainstay of treatment. Our aim was to study preoperative characteristics, surgical approaches, and outcome in patients with bronchopulmonary carcinoid tumors. PATIENTS AND METHODS: This retrospective study was done in the Department of Surgical Oncology of a Tertiary Teaching Hospital of North India. The case records of all the patients who underwent surgical treatment for lung neoplasms and were diagnosed to have bronchopulmonary carcinoids were reviewed...
January 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28405692/-pulmonary-carcinoid-tumors
#9
H Prosch
Pulmonary carcinoids are rare low-grade malignant tumors, which arise from the neuroendocrine system. Approximately 80% of all pulmonary carcinoid tumors are the relatively low-grade typical carcinoids and 20% are the more aggressive atypical carcinoids. Most carcinoids arise from the central airways and only a minority of carcinoids are found in the lung periphery. While most of the peripheral carcinoids are asymptomatic, central carcinoids are symptomatic and present with hemoptysis, wheezing or bronchial obstruction...
April 12, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28405320/distinct-metaplastic-and-inflammatory-phenotypes-in-autoimmune-and-adenocarcinoma-associated-chronic-atrophic-gastritis
#10
Sangho Jeong, Eunyoung Choi, Christine P Petersen, Joseph T Roland, Alessandro Federico, Rossana Ippolito, Francesco P D'Armiento, Gerardo Nardone, Osamu Nagano, Hideyuki Saya, Marco Romano, James R Goldenring
BACKGROUND: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. METHODS: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28399530/68gallium-dotanoc-pet-imaging-in-lung-carcinoids-impact-on-patients-management
#11
Angela Lamarca, D Mark Pritchard, Thomas Westwood, Georgios Papaxoinis, Daisuke Nonaka, Sobhan Vinjamuri, Juan W Valle, Prakash Manoharan, Wasat Mansoor
No abstract text is available yet for this article.
April 12, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28398699/pneumocytoma-sclerosing-hemangioma-a-potential-pitfall
#12
Erika Hissong, Rema Rao
Pneumocytoma is an uncommon benign tumor of the lung, derived from primitive respiratory epithelium, with a predilection for middle-aged females. A single, well-circumscribed mass is commonly identified on imaging, necessitating pathologic evaluation for further assessment. Fine-needle aspiration cytology is a minimally invasive and cost-effective method that can be utilized in the diagnosis of these lesions. Yet, distinction of pneumocytoma from other entities such as well-differentiated adenocarcinoma or carcinoid tumor can be quite challenging...
April 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28394114/ovarian-teratoma-in-routine-biopsy-material-during-a-five-year-period
#13
Marina Kos, Jasmina Nikić, Tanja Leniček
Teratomas are tumors derived from germ cells, most frequently arising in the gonads. The aim of this study was to determine the number of ovarian teratomas diagnosed in the routine biopsy material at Ljudevit Jurak Clinical Department of Pathology, Sestre milosrdnice University Hospital Center during a 5-year period, as well as their clinical, gross and microscopic characteristics. Teratomas accounted for 48.6% (n=166) of primary ovarian tumors. The patient mean age was 34.74±12.37 years. Difference in the incidence of teratoma between the left and right ovary was not significant; bilateral teratoma was found in 13 patients...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28389994/neuroendocrine-tumors-of-the-breast
#14
REVIEW
Daniel W Visscher, Saba Yasir
A small but increasingly recognized and studied subset of breast carcinomas are characterized by neuroendocrine (NE) differentiation. As with nearly all forms of breast neoplasia, NE tumors are characterized by considerable heterogeneity in microscopic appearance and clinical aggressiveness. About half of NE breast carcinomas recapitulate the histological spectrum typical of their counterparts in other organ systems, varying from "carcinoid-like" to small cell carcinoma, with most representing intermediate grade tumors...
April 8, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28384065/phase-iii-prospective-randomized-comparison-trial-of-depot-octreotide-plus-interferon-alfa-2b-versus-depot-octreotide-plus-bevacizumab-in-patients-with-advanced-carcinoid-tumors-swog-s0518
#15
James C Yao, Katherine A Guthrie, Cesar Moran, Jonathan R Strosberg, Matthew H Kulke, Jennifer A Chan, Noelle LoConte, Robert R McWilliams, Edward M Wolin, Bassam Mattar, Shannon McDonough, Helen Chen, Charles D Blanke, Howard S Hochster
Purpose Treatment options for neuroendocrine tumors (NETs) remain limited. This trial assessed the progression-free survival (PFS) of bevacizumab or interferon alfa-2b (IFN-α-2b) added to octreotide among patients with advanced NETs. Patients and Methods Southwest Oncology Group (SWOG) S0518, a phase III study conducted in a US cooperative group system, enrolled patients with advanced grades 1 and 2 NETs with progressive disease or other poor prognostic features. Patients were randomly assigned to treatment with octreotide LAR 20 mg every 21 days with either bevacizumab 15 mg/kg every 21 days or 5 million units of IFN-α-2b three times per week...
April 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28382568/telotristat-ethyl-first-global-approval
#16
Anthony Markham
Telotristat ethyl (Xermelo™) is a peripheral tryptophan hydroxylase (TPH) inhibitor that was developed by Lexicon Pharmaceuticals, Inc. for the treatment of carcinoid syndrome. Many neuroendocrine tumours secrete serotonin (5-HT) into the blood stream, resulting in a number of symptoms, notably diarrhoea. Telotristat ethyl inhibits TPH, thereby reducing the production of 5-HT. In February 2017, telotristat ethyl was approved in the USA for the treatment of carcinoid syndrome diarrhoea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy...
April 5, 2017: Drugs
https://www.readbyqxmd.com/read/28379023/-cardiovascular-complications-of-cancers-and-anti-cancer-therapy
#17
Jiří Vyskočil, Katarína Petráková, Petr Jelínek, Michal Furdek
In our aging population the incidence of cancer is increasing in the elderly. We are thus facing a new challenge especially considering incidence of cardiovascular diseases (CVD) in this patients population. Overall survival of cancer patients has significantly improved therefore cancer has become in many cases a chronic disease. We are about to be treating patients who either may develop a new CVD or their current CVD may deteriorate. Cancer can cause various cardiovascular conditions locally (pressure in mediastinum, effusions) or systemically (increased risk of pulmonary embolism, arrhythmias, carcinoid heart disease)...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28369403/serum-gastrin-and-cholecystokinin-are-associated-with-subsequent-development-of-gastric-cancer-in-a-prospective-cohort-of-finnish-smokers
#18
Gwen Murphy, Christian C Abnet, Hyoyoung Choo-Wosoba, Emily Vogtmann, Stephanie J Weinstein, Philip R Taylor, Satu Männistö, Demetrius Albanes, Sanford M Dawsey, Jens F Rehfeld, Neal D Freedman
Background: Gastrin, which induces gastric acid secretion, and a structurally similar hormone, cholecystokinin (CCK)-a potent acid inhibitor, may each play a role in gastric cancer. However, few studies have investigated this hypothesis in humans. We therefore investigated whether serum gastrin or CCK concentrations at baseline were associated with the incidence of gastric non-cardia adenocarcinomas (GNCA), oesophagogastric junctional adenocarcinomas (EGJA) or gastric carcinoid tumours over 24 years of follow-up in a study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of Finnish smokers...
March 27, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28363472/surgical-management-and-surveillance-of-pediatric-appendiceal-carcinoid-tumor
#19
Inna N Lobeck, Neelum Jeste, James Geller, Joseph Pressey, Daniel von Allmen
PURPOSE: Appendiceal carcinoid tumors are rare neuroendocrine neoplasms. The aim of this study was to determine if postoperative oncologic follow-up was necessary for this tumor. METHODS: A retrospective review was performed of patients with appendiceal carcinoid 2000-2015. RESULTS: 8382 patients underwent appendectomy 2000-2015. 30 (0.3%) had appendiceal carcinoid. 70% were female (n=21) with an average age of 13.5±2.8 years (range 8-18)...
March 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28360817/carcinoid-tumor-associated-paraneoplastic-polyneuropathy-that-mimics-guillain-barre-syndrome
#20
Çetin Kürşad Akpinar, Hacer Erdem Tilki, Hüseyin Şahin, Taner Özbenli
No abstract text is available yet for this article.
December 2016: Noro Psikiyatri Arsivi
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