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https://www.readbyqxmd.com/read/28944958/paclitaxel-related-scleredema-like-skin-changes-in-a-patient-with-breast-cancer
#1
Naomi Tani, Kazunari Sugita, Osamu Yamamoto
No abstract text is available yet for this article.
September 25, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28944922/microrna%C3%A2-372-inhibits-proliferation-and-induces-apoptosis-in-human-breast-cancer-cells-by-directly-targeting-e2f1
#2
Ya-Xin Zhao, Hua-Cheng Liu, Wei-Yang Ying, Cheng-Yu Wang, Yao-Jun Yu, Wei-Jian Sun, Jie-Fan Liu
Breast cancer is the most prevalent cancer and the leading cause of cancer‑associated mortalities among women worldwide today. Accumulating evidence suggested that miR‑372 may serve important roles in the initiation and development of various human cancers. However, the role of miR‑372 in breast cancer remains unknown. The present study demonstrated that the expression level of miR‑372 in human breast cancer tissues and cell lines is significantly reduced compared with normal breast tissues cell lines...
September 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944917/application-of-a-co%C3%A2-expression-network-for-the-analysis-of-aggressive-and-non%C3%A2-aggressive-breast-cancer-cell-lines-to-predict-the-clinical-outcome-of-patients
#3
Ling Guo, Kun Zhang, Zhitong Bing
Breast cancer metastasis is a demanding problem in clinical treatment of patients with breast cancer. It is necessary to examine the mechanisms of metastasis for developing therapies. Classification of the aggressiveness of breast cancer is an important issue in biological study and for clinical decisions. Although aggressive and non‑aggressive breast cancer cells can be easily distinguished among different cell lines, it is very difficult to distinguish in clinical practice. The aim of the current study was to use the gene expression analysis from breast cancer cell lines to predict clinical outcomes of patients with breast cancer...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944911/microrna%C3%A2-3666-inhibits-breast-cancer-cell-proliferation-by-targeting-sirtuin-7
#4
Di Li, Lifei Li
The abnormal expression of microRNAs (miRNAs) is associated with cancer initiation and progression. miRNAs functioning as oncogenes or tumor suppressors represent novel biomarkers for cancer diagnosis, prognosis, and serve as therapeutic tools. MiR‑3666 has been reported as a tumor suppressor in various types of cancer; however, its role in breast cancer remains unknown. In the current study, the aim was to investigate the potential role of miR‑3666 in breast cancer. It was identified that miR‑3666 was decreased in breast cancer cell lines and that the overexpression of miR‑3666 inhibited breast cancer cell proliferation...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944897/high-expression-of-endoglin-in-primary-breast-cancer-may-predict-response-to-neoadjuvant-chemotherapy
#5
Kun-Ming Rau, Yu-Li Su, Shan-Hsuan Li, Meng-Che Hsieh, Shis-Chung Wu, Fong-Fu Chou, Tai-Jan Chiu, Yen-Hao Chen, Chien-Ting Liu
Neoadjuvant chemotherapy (NAC) is a widely‑used treatment for breast cancer, as it may render unresecta-ble breast tumors to become resectable. In addition, NAC provides the unique opportunity to assess response to treatments within months rather than years of follow‑up. However, predictive markers of tumor response to NAC are lacking. Therefore, the present study aimed to investigate the expression of endoglin, a marker of angiogenesis, and its association with pathologic responses to NAC. Samples from 34 breast cancer patients were obtained prior to and following NAC treatment...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944853/kisspeptin-inhibits-cancer-growth-and-metastasis-via-activation-of-eif2ak2
#6
Tae-Hun Kim, Sung-Gook Cho
Kisspeptin is a protein encoded by the KISS1 gene, which has been reported to suppress the metastatic capabilities of various types of cancer cells, through the activation of its G‑protein coupled receptor GPR54. However, the molecular mechanisms underlying the involvement of kisspeptin‑mediated signaling in the inhibition of cancer cell migration and invasion have yet to be elucidated. The present in vitro cell proliferation, migration and invasion assays and in vivo experimental metastasis studies demonstrated that kisspeptin‑induced eukaryotic translation initiation factor 2α kinase 2 (EIF2AK2) activation suppressed the metastatic capabilities of several types of cancer cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944768/a-large-metastatic-intramammary-lesion-of-an-occult-melanoma
#7
Eleonora Nacchiero, Stefania Stucci, Paolo Annoscia, Michelangelo Vestita, Rossella Elia, Paolo Claudio Marannino
OBJECTIVE: Malignant melanomas presenting with unknown primaries are uncommon. In the majority of cases metastases of occult melanoma were detected in skin or in lymph nodes. Melanoma can rarely occur as a primary or metastatic intramammary tumor. CASE REPORT: We report the case of a 58-year-old Caucasian woman who came to our department with a voluminous mass in her right breast. Histopathological examination found metastasis of epithelioid melanoma with unknown primary lesion...
September 4, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28944729/using-performance-based-risk-sharing-arrangements-to-address-uncertainty-in-indication-based-pricing
#8
Kai Yeung, Meng Li, Josh J Carlson
BACKGROUND: The rise in pharmaceutical expenditures in recent years has increased health care payer interest in ensuring good value for the money. Indication-based pricing (IBP) sets separate, indication-specific prices paid to the manufacturer according to the expected efficacy of a drug in each of its indications. IBP allows payers to consistently pay for value across indications. While promising, a limitation of IBP as originally conceived is that efficacy estimates are typically based on clinical trial data, which may differ from real-world effectiveness...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944716/breast-cancer-screening-among-women-in-namibia-explaining-the-effect-of-health-insurance-coverage-and-access-to-information-on-screening-behaviours
#9
Joseph Kangmennaang, Paul Mkandawire, Isaac Luginaah
OBJECTIVES: Breast cancer contributes substantially to morbidity and mortality in Namibia as is the case in most countries in Sub-Saharan Africa (SSA). However, there is a dearth of nationally representative studies that examine the odds of screening for breast cancer in Namibia and SSA at large. This paper aims to fill this gap by examining the determinants of breast cancer screening guided by the Health Belief Model. METHODS: We applied hierarchical binary logit regression models to explore the determinants of breast cancer screening using the 2013 Namibia Demography and Health Survey (NDHS)...
September 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28944624/immediate-autologous-breast-reconstruction-after-neoadjuvant-chemoradiotherapy-for-breast-cancer-initial-results-of-the-first-29-patients
#10
Damien Grinsell, Meron Pitcher, Shirley Wong, Mario Guerrieri, Hans H M Nielsen
BACKGROUND: Breast reconstruction after mastectomy in the treatment of locally advanced breast cancer is often done in stages and before radiotherapy. We have previously published an algorithm for immediate free autologous reconstruction after neoadjuvant chemotherapy and preoperative radiotherapy. This protocol was designed to provide a shorter and simpler reconstructive path whilst improving cosmesis and maintaining oncological efficiency. METHODS: A total of 29 patients were included and underwent surgery for 30 cancers by the first author between 2010 and September 2015...
September 24, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28944521/interventions-for-raising-breast-cancer-awareness-in-women
#11
Catriona Kennedy
No abstract text is available yet for this article.
September 24, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28944452/nano-pulse-stimulation-induces-potent-immune-responses-eradicating-local-breast-cancer-while-reducing-distant-metastases
#12
Siqi Guo, Yu Jing, Niculina I Burcus, Brittany P Lassiter, Royena Tanaz, Richard Heller, Stephen J Beebe
Nano-Pulse Stimulation (NPS) as a developing technology has been studied for minimally invasive, non-thermal local cancer elimination for more than a decade. Here we show that a single NPS treatment results in complete regression of the poorly immunogenic, metastatic 4T1-Luc mouse mammary carcinoma. Impressively, spontaneous distant organ metastases were largely prevented, even in those animals with incomplete tumor regression. All tumor-free mice were protected from secondary tumor cell challenge, demonstrating a vaccine-like effect...
September 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28944451/expression-of-mirna-26b-5p-and-its-target-trps1-is-associated-with-radiation-exposure-in-post-chernobyl-breast-cancer
#13
Christina M Wilke, Julia Hess, Sergiy V Klymenko, Vadim V Chumak, Liubov M Zakhartseva, Elena V Bakhanova, Annette Feuchtinger, Axel K Walch, Martin Selmansberger, Herbert Braselmann, Ludmila Schneider, Adriana Pitea, Julia Steinhilber, Falko Fend, Hans C Bösmüller, Horst Zitzelsberger, Kristian Unger
Ionising radiation is a well-recognised risk factor for the development of breast cancer, however, it is unknown whether radiation-specific molecular oncogenic mechanisms exist. We investigated post-Chernobyl breast cancers from radiation-exposed female clean-up workers and non-exposed controls for molecular changes. Radiation-associated alterations identified in the discovery cohort (n=38) were subsequently validated in a second cohort (n=39). Increased expression of hsa-miR-26b-5p was associated with radiation exposure in both of the cohorts...
September 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28944429/search-of-micrornas-regulating-the-receptor-status-of-breast-cancer-in-silico-and-experimental-confirmation-of-their-expression-in-tumors
#14
V S Chernyi, P V Tarasova, V V Kozlov, O V Saik, N E Kushlinskii, L F Gulyaeva
MicroRNA whose expression depends on the receptor status of breast cancer were selected using bioinformatic analysis. The expression of 9 microRNAs (16, 17, 21, 27, 125, 146, 155, 200a, and 221) was analyzed in 76 samples of breast cancer with various receptor phenotypes. The expression of microRNAs 155, 27, and 200a did not differ in various types of breast cancer. The data on positive correlation between the expression of microRNA-21 and microRNA-221 and negative receptor status of the tumor were confirmed...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28944289/video-intervention-increases-participation-of-black-breast-cancer-patients-in-therapeutic-trials
#15
Brandi N Robinson, Antoinette F Newman, Eshetu Tefera, Pia Herbolsheimer, Raquel Nunes, Christopher Gallagher, Pamela Randolph-Jackson, Adedamola Omogbehin, Asma Dilawari, Paula R Pohlmann, Mahsa Mohebtash, Young Lee, Yvonne Ottaviano, Avani Mohapatra, Filipa Lynce, Richard Brown, Mihriye Mete, Sandra M Swain
There is a striking racial and ethnic disparity in incidence and mortality of cancer yet minorities remain markedly underrepresented in clinical trials. This pilot study set out to determine the impact of a 15-min culturally tailored educational video on three outcomes relating to clinical trials: likely participation, attitudes (assessed based on six barriers), and actual enrollment. Breast cancer patients with Stage I-III, if diagnosed within previous 6 months, or metastatic disease who self-identified as black or African American were invited to participate...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28944288/the-wisdom-study-breaking-the-deadlock-in-the-breast-cancer-screening-debate
#16
REVIEW
Laura J Esserman
There are few medical issues that have generated as much controversy as screening for breast cancer. In science, controversy often stimulates innovation; however, the intensely divisive debate over mammographic screening has had the opposite effect and has stifled progress. The same two questions-whether it is better to screen annually or bi-annually, and whether women are best served by beginning screening at 40 or some later age-have been debated for 20 years, based on data generated three to four decades ago...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28944260/post-treatment-survivorship-care-needs-of-spanish-speaking-latinas-with-breast-cancer
#17
Anna María Nápoles, Carmen Ortiz, Jasmine Santoyo-Olsson, Anita L Stewart, Howard E Lee, Ysabel Duron, Niharika Dixit, Judith Luce, Diana J Flores
BACKGROUND: A comprehensive assessment of Spanish-speaking breast cancer survivors' (SSBCS) survivorship needs is lacking. OBJECTIVE: Assess SSBCS' post-treatment symptom management, psychosocial, and informational needs. METHODS: 118 telephone surveys and 25 in-person semi-structured interviews with SSBCS, and semi-structured interviews with 5 support providers and 4 physicians who serve SSBCS from 5 Northern California counties. RESULTS: Surveys identified the most bothersome (bothered by it in the past month "somewhat/quite a bit/a lot") physical symptoms as: joint pain, fatigue, hot flashes, numbness in hands/feet, and vaginal dryness...
2017: Journal of Community and Supportive Oncology
https://www.readbyqxmd.com/read/28944232/mutational-analysis-of-brca1-and-brca2-genes-in-peruvian-families-with-hereditary-breast-and-ovarian-cancer
#18
Jose Buleje, Maria Guevara-Fujita, Oscar Acosta, Francia D P Huaman, Pierina Danos, Alexis Murillo, Joseph A Pinto, Jhajaira M Araujo, Alfredo Aguilar, Jaime Ponce, Carlos Vigil, Carlos Castaneda, Gabriela Calderon, Henry L Gomez, Ricardo Fujita
BACKGROUND: Breast cancer is one of the most prevalent malignancies in the world. In Peru, breast cancer is the second cause of death among women. Five to ten percent of patients present a high genetic predisposition due to BRCA1 and BRCA2 germline mutations. METHODS: We performed a comprehensive analysis of BRCA1 and BRCA2 genes by Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA) to detect large rearrangements in patients from 18 families, which met the criteria for hereditary breast cancer...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944120/treatment-of-male-breast-cancer-by-dual-human-epidermal-growth-factor-receptor-2-her2-blockade-and-response-prediction-using-novel-optical-tomography-imaging-a-case-report
#19
Debasmita Saha, Susan Tannenbaum, Quing Zhu
Male breast cancer, although rare, is on the rise. Prospective clinical trials are unlikely and current management mirrors that of post-menopausal women. Neoadjuvant chemotherapy is widely used and pathologic complete response (pCR) predicts long-term survival. The addition of dual HER2 (human epidermal growth factor receptor 2) blockade has shown the highest pCR rates; however, there is no published data of this approach in men. Also, newer monitoring tools are necessary during a neoadjuvant therapy to help personalize treatment...
July 17, 2017: Curēus
https://www.readbyqxmd.com/read/28944118/dramatic-response-of-an-aggressive-chest-wall-recurrence-to-hyperthermia-radiation-and-chemotherapy
#20
Justin Cohen, Stephanie Rice, Tejan Diwanji, Steven J Feigenberg, Zeljko Vujaskovic
Hyperthermia has been demonstrated to be an effective adjuvant oncological treatment modality in combination with chemotherapy and/or radiation. Published data have demonstrated that the addition of hyperthermia can improve local control for breast cancer chest wall recurrences. We present a patient with a very aggressive estrogen receptor-negative, progesterone receptor-negative, HER2/neu receptor-negative chest wall recurrence status-post a right modified radical mastectomy. Despite having metastatic disease, in an attempt to achieve local control and provide palliation, she was treated with hyperthermia, radiation, and chemotherapy...
July 16, 2017: Curēus
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