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https://www.readbyqxmd.com/read/29161781/in-silico-docking-studies-of-lupeol-with-mapk-pathway-proteins-raf-1-mek-erk
#1
Mital H Bhatt, Chirag K Prajapati, M N Reddy
Lupeol, A triterpenoid found in variety of plants is reported to have beneficial medicinal effects on several ailments. Lupeol is also found to show inhibitory effect on proliferation of breast cancer cells. Metastasis is considered to be a major cause for worldwide deaths related to cancer. Ras related MAPK Signaling Pathway is one of the crucial pathways leading to metastasis. Lupeols binding possibility with Ras is already reported. In present study, Interaction between with downstream proteins of Ras- MAPK pathway, Raf ,MEK ,ERK1/2 and their corresponding domains are studied using STRING Database and their structures are retrieved in PDB Format...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161698/a-comparison-of-three-methods-for-the-detection-of-circulating-tumor-cells-in-patients-with-early-and-metastatic-breast-cancer
#2
Eleni Politaki, Sofia Agelaki, Stella Apostolaki, Dora Hatzidaki, Areti Strati, Filippos Koinis, Maria Perraki, Georgia Saloustrou, Giannis Stoupis, Galatea Kallergi, Maria Spiliotaki, Tereza Skaltsi, Evi Lianidou, Vassilis Georgoulias, Dimitrios Mavroudis
BACKGROUND: We directly compared CTC detection rates and prognostic significance, using three different methods in patients with breast cancer (BC). METHODS: Early (n=200) and metastatic (n=164) patients were evaluated before initiating adjuvant or first-line chemotherapy, using the CellSearchTM System, an RT-qPCR for CK-19 mRNA detection and by double immunofluorescence (IF) microscopy using A45-B/B3 and CD45 antibodies. RESULTS: Using the CellSearchTM System, 37% and 16...
November 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161653/psychosocial-issues-of-a-population-approach-to-high-genetic-risk-identification-behavioural-emotional-and-informed-choice-issues
#3
David P French, Anthony Howell, D Gareth Evans
To allow women at high genetic risk of breast cancer to benefit from prevention or early prevention strategies, a screening programme is required to identify them. The present review considers the likelihood of key outcomes that would arise from such a programme, in relation to behavioural, emotional and informed choice outcomes. The likelihood of outcomes in each category is considered in relation to the limited direct evidence and relevant indirect evidence, given the dearth of studies that have directly studied the effects of communication of personal genetic risk of breast cancer...
November 18, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29161652/impact-of-body-mass-index-on-the-clinical-outcomes-of-patients-with-her2-positive-metastatic-breast-cancer
#4
Samuel Martel, Elena Poletto, Arlindo R Ferreira, Matteo Lambertini, Federico Sottotetti, Ilaria Bertolini, Filippo Montemurro, Antonio Bernardo, Emanuela Risi, Elisa Zanardi, Serena Ziliani, Silvia Mura, Chiara Dellepiane, Lucia Del Mastro, Alessandro Marco Minisini, Fabio Puglisi
BACKGROUND: Overweight and obesity are associated with an increased risk of developing many types of cancer, including breast cancer. Moreover, increased body mass index (BMI) seems to be associated with a worse prognosis in patients with HER2-positive early breast cancer. However, little is known about the impact of BMI on the clinical outcomes of HER2-positive metastatic breast cancer (MBC). METHODS: This was a multicenter retrospective cohort study including 329 consecutive patients with HER2-positive MBC treated with first-line trastuzumab-based regimens...
November 18, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29161627/nanoscaled-red-blood-cells-facilitate-breast-cancer-treatment-by-combining-photothermal-photodynamic-therapy-and-chemotherapy
#5
Guoyun Wan, Bowei Chen, Ling Li, Dan Wang, Shurui Shi, Tao Zhang, Yue Wang, Lianyun Zhang, Yinsong Wang
Red blood cells (RBCs)-based vesicles have been widely used for drug delivery due to their unique advantages. Intact RBCs contain a large amount of oxyhemoglobin (oxyHb), which can assist with photodynamic therapy (PDT). Indocyanine green (ICG), a photosensitizer both for photothermal therapy (PTT) and PDT, shows potent anticancer efficacy when combined with chemotherapeutic drug doxorubicin (DOX). In this study, we prepared nanoscaled RBCs (RAs) containing oxyHb and gas-generating agent ammonium bicarbonate (ABC) for co-loading and controlled release of ICG and DOX, thus hoping to achieve synergistic effects of PTT/PDT and chemotherapy against breast cancer...
November 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/29161609/cancers-in-france-in-2015-attributable-to-high-body-mass-index
#6
Melina Arnold, Marina Touillaud, Laure Dossus, Heinz Freisling, Freddie Bray, Irène Margaritis, Valérie Deschamps, Isabelle Soerjomataram
BACKGROUND: Overweight, as defined by high body mass index (BMI), is an established risk factor for various morbidities including cancer. Globally, its prevalence has increased markedly over the past decades. The aim of this study was to estimate the proportion and number of cancers that were attributable to high BMI in France in 2015. METHODS: Population attributable fractions (PAFs) and numbers of cancer cases attributable to high BMI (a population mean BMI above the optimum of 22kg/m(2)) were estimated by age and sex, for cancer sites with convincing or probable evidence of an established causal link...
November 18, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29161592/tumor-suppressor-inactivation-of-gdf11-occurs-by-precursor-sequestration-in-triple-negative-breast-cancer
#7
Sameer S Bajikar, Chun-Chao Wang, Michael A Borten, Elizabeth J Pereira, Kristen A Atkins, Kevin A Janes
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous carcinoma in which various tumor-suppressor genes are lost by mutation, deletion, or silencing. Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and an unusual mechanism of its inactivation in TNBC. GDF11 promotes an epithelial, anti-invasive phenotype in 3D triple-negative cultures and intraductal xenografts by sustaining expression of E-cadherin and inhibitor of differentiation 2 (ID2). Surprisingly, clinical TNBCs retain the GDF11 locus and expression of the protein itself...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161300/brca1-and-brca2-mutational-profile-and-prevalence-in-hereditary-breast-and-ovarian-cancer-hboc-probands-from-southern-brazil-are-international-testing-criteria-appropriate-for-this-specific-population
#8
Bárbara Alemar, Cleandra Gregório, Josef Herzog, Camila Matzenbacher Bittar, Cristina Brinckmann Oliveira Netto, Osvaldo Artigalas, Ida Vanessa D Schwartz, Jordy Coffa, Suzi Alves Camey, Jeffrey Weitzel, Patricia Ashton-Prolla
BACKGROUND: Germline pathogenic variants in BRCA1 and BRCA2 (BRCA) are the main cause of Hereditary Breast and Ovarian Cancer syndrome (HBOC). METHODS: In this study we evaluated the mutational profile and prevalence of BRCA pathogenic/likely pathogenic variants among probands fulfilling the NCCN HBOC testing criteria. We characterized the clinical profile of these individuals and explored the performance of international testing criteria. RESULTS: A pathogenic/likely pathogenic variant was detected in 19...
2017: PloS One
https://www.readbyqxmd.com/read/29161296/epithelial-periostin-expression-is-correlated-with-poor-survival-in-patients-with-invasive-breast-carcinoma
#9
Ga-Eon Kim, Ji Shin Lee, Min Ho Park, Jung Han Yoon
Invasion and metastasis are direct causes of mortality in patients with breast cancer and require reciprocal interactions between cancer cells and the extracellular matrix (ECM). Periostin, a fasciclin-containing adhesive ECM glycoprotein, is frequently overexpressed in various types of human cancer, and its overexpression in cancer-associated stroma and/or cancer cells is usually associated with poor clinical outcomes. However, the expression of periostin in the successive steps of breast tumorigenesis and its association with outcome variables have not been well established in breast carcinoma...
2017: PloS One
https://www.readbyqxmd.com/read/29161005/esi-ms-for-microsized-bioparticles
#10
Abdil Ozdemir, Jung-Lee Lin, Mustafa Gulfen, Szu-Hsueh Lai, Chun-Jen Hsiao, Nelson Gee-Con Chen, Chung-Hsuan Chen
An ESI ion trap mass spectrometer was designed for high throughput and rapid mass analysis of large bio-particles. Mass calibration of the instrument was performed using commercially available polystyrene micro-particles, and the selected sizes of the polystyrene (PS) particles were approximately 3 to 15 µm, which is consistent with the size of the cancer cells selected for this work. It provides the analysis of micro-sized inorganic and bioparticles. Different sizes of MCF-7 breast cancer cells (8 to 15 µm) were used in this study...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160836/an-in-vitro-study-of-the-photodynamic-effectiveness-of-go-ag-nanocomposites-against-human-breast-cancer-cells
#11
Fozia Shaheen, Muhammad Hammad Aziz, Muhammad Fakhar-E-Alam, Muhammad Atif, Mahvish Fatima, Riaz Ahmad, Atif Hanif, Saqib Anwar, Fatima Zafar, Ghazanfar Abbas, Syed Mansoor Ali, Mukhtar Ahmed
Graphene-based materials have garnered significant attention because of their versatile bioapplications and extraordinary properties. Graphene oxide (GO) is an extremely oxidized form of graphene accompanied by the functional groups of oxygen on its surface. GO is an outstanding platform on which to pacify silver nanoparticles (Ag NPs), which gives rise to the graphene oxide-silver nanoparticle (GO-Ag) nanocomposite. In this experimental study, the toxicity of graphene oxide-silver (GO-Ag) nanocomposites was assessed in an in vitro human breast cancer model to optimize the parameters of photodynamic therapy...
November 21, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29160721/isolated-atypical-lobular-hyperplasia-diagnosed-on-breast-biopsy-low-upgrade-rate-on-subsequent-excision-with-long-term-follow-up
#12
Kristen E Muller, Emily Roberts, Lili Zhao, Julie M Jorns
CONTEXT: - The upgrade rate to carcinoma on excision for atypical lobular hyperplasia diagnosed on breast biopsy is controversial. OBJECTIVE: - To review cases with isolated atypical lobular hyperplasia on biopsy to establish the rate of upgrade on excision and correlate with long-term follow-up. DESIGN: - A database search was performed for 191 months to identify breast core biopsies with isolated atypical lobular hyperplasia. Cases with other atypical lesions in the biopsy or discordant radiologic-pathologic findings were excluded...
November 21, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29160558/simpson-s-paradox-in-the-integrated-discrimination-improvement
#13
J Chipman, D Braun
The integrated discrimination improvement (IDI) is commonly used to compare two risk prediction models; it summarizes the extent a new model increases risk in events and decreases risk in non-events. The IDI averages risks across events and non-events and is therefore susceptible to Simpson's paradox. In some settings, adding a predictive covariate to a well calibrated model results in an overall negative (positive) IDI. However, if stratified by that same covariate, the strata-specific IDIs are positive (negative)...
December 10, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29160470/actions-of-nurses-in-early-detection-of-breast-cancer
#14
Fabiana Barbosa Barreto Melo, Carla Andréia Vilanova Marques, Anderson da Silva Rosa, Elisabeth Niglio de Figueiredo, Maria Gaby Rivero de Gutiérrez
OBJECTIVE: Identify the actions for early detection of breast cancer performed by nurses from basic health units; compare the compliance of these actions with the recommendations from the Ministry of Health; analyze the availability of documents to check these recommendations and analyze the association of variables "training," "lato sensu training," and "years of activity" of these professionals with the actions performed. METHOD: A cross-sectional study conducted with 133 nurses from 38 basic health units in the Southeast region of the municipality of São Paulo, interviewed with a validated questionnaire...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29160419/synthesis-crystal-structure-and-anti-breast-cancer-activity-of-a-novel-metal-porphyrinic-complex-yk-tcpp-oh-2%C3%A2-solvents-x
#15
J-C Liu, J-J Gu, Y-S Zhang
A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined.
November 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29160213/cutaneous-metastases-of-internal-malignancies-an-experience-from-a-single-institution
#16
Elena Guanziroli, Antonella Coggi, Luigia Venegoni, Daniele Fanoni, Giulia Ercoli, Francesca Boggio, Stefano Veraldi, Emilio Berti, Raffaele Gianotti, Stefano Ferrero, Alessandro Del Gobbo
BACKGROUND: Cutaneous metastases represent 2% of all skin tumours. Their recognition can be challenging, as they may present with different clinical features, with consequent frequent delay and failure in diagnosis. OBJECTIVES: To review our series of cutaneous metastatic lesions, analyse their frequency according to patient gender, histotype, localization of the primary tumour, and site of cutaneous metastasis, and correlate this data with clinicopathological parameters...
November 21, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29159936/influence-of-socioeconomic-factors-and-distance-to-radiotherapy-on-breast-conserving-surgery-rates-for-early-breast-cancer-in-regional-australia-implications-of-change
#17
Ian M Collins, Caroline Lum, Vincent L Versace
AIMS: Breast conserving surgery rates are affected by many factors including distance to radiotherapy and tumor-related features. Numerous studies have found women who must travel further for radiotherapy are more likely to choose mastectomy and avoid radiotherapy. We examined relationships between socioeconomic group, distance to radiotherapy services and mastectomy rates across a range of rural and metropolitan settings. METHODS: We used a dataset extracted from the Evaluation of Cancer Outcomes Barwon South Western Registry, which captured data on new breast cancer diagnoses in the southwest region of Victoria, Australia...
November 21, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29159881/characterization-of-photon-counting-multi-slit-breast-tomosynthesis
#18
Karl Berggren, Björn Cederström, Mats Lundqvist, Erik Fredenberg
PURPOSE: It has been shown that breast tomosynthesis may improve sensitivity and specificity compared to 2D mammography, resulting in increased detection-rate of cancers or lowered call-back rates. The purpose of this study is to characterize a spectral photon-counting multi-slit breast tomosynthesis system that is able to do single-scan spectral imaging with multiple collimated x-ray beams. The system differs in many aspects compared to conventional tomosynthesis using energy-integrating flat-panel detectors...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159815/effectiveness-of-interventions-for-breast-cancer-screening-in-african-american-women-a-meta-analysis
#19
Valire Carr Copeland, Yoo Jung Kim, Shaun M Eack
OBJECTIVE: The purpose of this study was to report the results of a meta-analysis conducted on the effects of clinical trials in breast cancer screening for African American women between 1997 and 2017. DATA SOURCES: Articles published in English and in the United States, between January 1997 and March 2017, were eligible for inclusion if they (1) conducted psychosocial, behavioral, or educational interventions designed to increase screening mammography rates in predominantly African American women of all ages; (2) utilized a randomized, controlled trial (RCT) design; and (3) reported quantitative screening rates following the intervention...
November 21, 2017: Health Services Research
https://www.readbyqxmd.com/read/29159811/a-deep-learning-method-for-classifying-mammographic-breast-density-categories
#20
Aly A Mohamed, Wendie A Berg, Hong Peng, Yahong Luo, Rachel C Jankowitz, Shandong Wu
PURPOSE: Mammographic breast density is an established risk marker for breast cancer and is visually assessed by radiologists in routine mammogram image reading, using four qualitative Breast Imaging and Reporting Data System (BI-RADS) breast density categories. It is particularly difficult for radiologists to consistently distinguish the two most common and most variably assigned BI-RADS categories, i.e., "scattered density" and "heterogeneously dense". The aim of this work was to investigate a deep learning-based breast density classifier to consistently distinguish these two categories, aiming at providing a potential computerized tool to assist radiologists in assigning a BI-RADS category in current clinical workflow...
November 21, 2017: Medical Physics
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