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https://www.readbyqxmd.com/read/29153065/-genotypes-of-rhinoviruses-in-children-and-adults-patients-with-acute-respiratory-tract-infections
#1
Eda Demirkan, Sevin Kırdar, Emel Ceylan, Ayşe Yenigün, İmran Kurt Ömürlü
Rhinovirus (RV) is one of the most frequent causative agent of acute respiratory tract infections in the world. The virus may cause a mild cold, as well as more serious clinical symptoms in patients with immune system deficiency or comorbidities. Rhinoviruses have been identified by molecular methods under three types: RV-A, RV-B and RV-C. In most of the cases, it was reported that RV-A and RV-C were related with lower respiratory tract infections and asthma exacerbations, while RV-B was rarely reported in lower respiratory tract infections...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29149199/epidemiology-and-clinical-profile-of-pathogens-responsible-for-the-hospitalization-of-children-in-sousse-area-tunisia
#2
Ines Brini, Aida Guerrero, Naila Hannachi, Jihene Bouguila, Dorothea Orth-Höller, Amira Bouhlel, Lamia Boughamoura, Benjamin Hetzer, Wegene Borena, Britta Schiela, Dorothee Von Laer, Jalel Boukadida, Heribert Stoiber
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29143374/asthma-and-lung-function-in-adulthood-after-a-viral-wheezing-episode-in-early-childhood
#3
Katri Backman, Hertta Ollikainen, Eija Piippo-Savolainen, Kirsi Nuolivirta, Matti Korppi
BACKGROUND: Viral etiology of infection has a significant role in the long-term outcome of early-childhood wheezing. OBJECTIVE: This study examines asthma and lung function in adulthood after early-childhood wheezing induced by respiratory syncytial virus (RSV) and rhinovirus (RV). METHODS: A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland)...
November 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29131066/human-polyomavirus-wu-in-patients-with-respiratory-tract-infection-in-kuwait
#4
Sahar Essa, Wassim Chehadeh, Widad Al-Nakib
OBJECTIVE: To determine the circulating polyomavirus Washington University (WUV) strains among hospitalized patients with respiratory tract infections (RTI) in Kuwait. MATERIALS AND METHODS: Samples from 459 hospitalized children and adult patients with respiratory tract infections were screened for respiratory viruses by Polymerase chain reaction (PCR) techniques from April 2013 to April 2016. The VP2 gene from WUV-positive samples was sequenced and subjected to phylogenetic analysis...
November 7, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29124902/t-cell-responses-against-rhinovirus-species-a-and-c-in-asthmatic-and-healthy-children
#5
Cibele M Gaido, Caitlyn Granland, Ingrid A Laing, Peter N Le Souëf, Wayne R Thomas, Andrew J Currie, Belinda J Hales
BACKGROUND: Infections by rhinovirus (RV) species A and C are the most common causes of exacerbations of asthma and a major cause of exacerbations of other acute and chronic respiratory diseases. Infections by both species are prevalent in pre-school and school-aged children and, particularly for RV-C, can cause severe symptoms and a need for hospitalization. While associations between RV infection and asthma are well established, the adaptive immune-mechanisms by which RV infections influence asthma exacerbations are yet to be defined...
November 10, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29123648/novel-therapeutic-approaches-to-simultaneously-target-rhinovirus-infection-and-asthma-copd-pathogenesis
#6
REVIEW
Carmen Mirabelli, Els Scheers, Johan Neyts
Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD...
2017: F1000Research
https://www.readbyqxmd.com/read/29121479/cdhr3-genetics-and-rhinovirus-c-respiratory-illnesses
#7
Klaus Bønnelykke, Amaziah T Coleman, Michael D Evans, Jonathan Thorsen, Johannes Waage, Nadja H Vissing, Christian J Carlsson, Jakob Stokholm, Bo L Chawes, Leon E Jessen, Thea K Fischer, Yury A Bochkov, Carole Ober, Robert F Lemanske, Daniel J Jackson, James E Gern, Hans Bisgaard
Background Experimental evidence suggests that CDHR3 is a receptor for rhinovirus-C (RV-C), and a missense variant in this gene (rs6967330) is associated with childhood asthma with severe exacerbations. Objective To determine whether rs6967330 influences RV-C infections and illnesses in early childhood. Methods We studied associations between rs6967330 and respiratory infections and illnesses in the COPSAC2010 and COAST birth cohorts, where respiratory infections were monitored prospectively for the first 3 years of life...
November 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29118754/critical-role-of-plasmacytoid-dendritic-cells-in-regulating-gene-expression-and-innate-immune-responses-to-human-rhinovirus-16
#8
Yang Xi, Niamh M Troy, Denise Anderson, Olga M Pena, Jason P Lynch, Simon Phipps, Anthony Bosco, John W Upham
Though human rhinoviruses (HRVs) are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of impaired interferon (IFN) synthesis. Plasmacytoid dendritic cells (pDCs) are key IFN producing cells, though we know little about the role of pDC in HRV-induced immune responses. Herein, we used gene expression microarrays to examine HRV-activated peripheral blood mononuclear cells (PBMCs) from healthy people, in combination with pDC depletion, to assess whether observed gene expression patterns were pDC dependent...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29117172/corrigendum-host-dna-released-by-netosis-promotes-rhinovirus-induced-type-2-allergic-asthma-exacerbation
#9
Marie Toussaint, David J Jackson, Dawid Swieboda, Anabel Guedán, Theodora-Dorita Tsourouktsoglou, Yee Man Ching, Coraline Radermecker, Heidi Makrinioti, Julia Aniscenko, Michael R Edwards, Roberto Solari, Frédéric Farnir, Venizelos Papayannopoulos, Fabrice Bureau, Thomas Marichal, Sebastian L Johnston
This corrects the article DOI: 10.1038/nm.4332.
November 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29111214/association-of-rhinovirus-species-with-common-cold-and-asthma-symptoms-and-bacterial-pathogens
#10
Hiba Bashir, Kris Grindle, Rose Vrtis, Fue Vang, Teresa Kang, Lisa Salazar, Elizabeth Anderson, Tressa Pappas, Ronald Gangnon, Michael D Evans, Daniel J Jackson, Robert F Lemanske, Yury A Bochkov, James E Gern
No abstract text is available yet for this article.
October 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29106925/nosocomial-transmission-and-genetic-diversity-of-rhinovirus-in-a-neonatal-intensive-care-unit
#11
Débora Natalia Marcone, Guadalupe Carballal, Mariela Irañeta, Yamile Rubies, Santiago M Vidaurreta, Marcela Echavarría
Rhinoviruses were detected as sole pathogens in 6 preterm infants who developed severe respiratory infections while hospitalized in a neonatal intensive care unit. We confirmed 2 nosocomial rhinovirus transmission episodes and describe the genetic diversity of rhinovirus strains that circulated simultaneously during a winter season.
October 26, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29106589/a-multicenter-consortium-to-define-the-epidemiology-and-outcomes-of-inpatient-respiratory-viral-infections-in-pediatric-hematopoietic-stem-cell-transplant-recipients
#12
Brian T Fisher, Lara Danziger-Isakov, Leigh R Sweet, Flor M Munoz, Gabriela Maron, Elaine Tuomanen, Alistair Murray, Janet A Englund, Daniel Dulek, Natasha Halasa, Michael Green, Marian G Michaels, Rebecca Pellett Madan, Betsy C Herold, William J Steinbach
Background: Respiratory virus infections (RVIs) pose a threat to children undergoing hematopoietic stem cell transplantation (HSCT). In this era of sensitive molecular diagnostics, the incidence and outcome of HSCT recipients who are hospitalized with RVI (H-RVI) are not well described. Methods: A retrospective observational cohort of pediatric HSCT recipients (between January 2010 and June 2013) was assembled from 9 US pediatric transplant centers. Their medical charts were reviewed for H-RVI events within 1 year after their transplant...
July 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29105099/risk-factors-for-asthma-after-infant-bronchiolitis
#13
S Törmänen, E Lauhkonen, R Riikonen, Petri Koponen, H Huhtala, M Helminen, M Korppi, K Nuolivirta
BACKGROUND: Five studies carried out after bronchiolitis at less than 24 months of age, with a follow up of more than 10 years, reported that atopic dermatitis, family asthma, early-life exposure to tobacco smoke and rhinovirus aetiology were early-life risk factors for later asthma. This study evaluated the long-term outcome at 11-13 years of age of children who were hospitalised for bronchiolitis in early infancy. METHODS: We previously prospectively followed 166 children hospitalised for bronchiolitis at less than six months of age until 5-7 years of age...
November 4, 2017: Allergy
https://www.readbyqxmd.com/read/29079159/respiratory-syncytial-virus-and-other-noninfluenza-respiratory-viruses-in-older-adults
#14
REVIEW
Fumihiro Kodama, David A Nace, Robin L P Jump
Respiratory viral infections may cause serious complications for older adults, including residents of long-term care facilities (LTCFs). Although influenza is the most common cause of viral respiratory infections among older adults, several other respiratory viruses also cause significant morbidity and mortality, most notably respiratory syncytial virus. Other noninfluenza respiratory viral pathogens include human metapneumovirus, parainfluenza virus, rhinovirus, coronavirus, and adenovirus. All of these may cause outbreaks among LTCF residents...
December 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29069373/detection-of-influenza-c-viruses-among-outpatients-and-patients-hospitalized-for-severe-acute-respiratory-infection-minnesota-2013-2016
#15
Beth K Thielen, Hannah Friedlander, Sarah Bistodeau, Bo Shu, Brian Lynch, Karen Martin, Erica Bye, Kathyrn Como-Sabetti, David Boxrud, Anna K Strain, Sandra S Chaves, Andrea Steffens, Ashley L Fowlkes, Stephen Lindstrom, Ruth Lynfield
Background: Existing literature suggests that influenza C typically causes mild respiratory tract disease. However, clinical and epidemiological data are limited. Methods: Four outpatient clinics and three hospitals submitted clinical data and respiratory specimens through a surveillance network for acute respiratory infection (ARI) during May 2013 through December 2016. Specimens were tested using multi-target nucleic acid amplification tests (NAAT) for 19-22 respiratory pathogens, including influenza C...
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29049949/rhinovirus-viremia-in-adult-patients-with-high-viral-load-in-bronchoalveolar-lavages
#16
Anneloes L Van Rijn, Eric C Claas, Peter A von dem Borne, Aloys C M Kroes, Jutte J C de Vries
BACKGROUND: In children, rhinovirus viremia has been associated with higher nasopharyngeal loads and increase in severity of clinical signs and symptoms. OBJECTIVES: This study aims to detect rhinovirus viremia in adult patients and to establish potential correlations with the clinical course. STUDY DESIGN: Adult patients with rhinovirus strongly positive bronchoalveolar lavages (BAL, quantitation cycle, Cq values <25) detected between 2008 and 2014 were studied retrospectively...
October 12, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29049206/the-molecular-epidemiology-of-respiratory-viruses-associated-with-asthma-attacks-a-single-center-observational-study-in-japan
#17
Takeshi Saraya, Hirokazu Kimura, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
Few reports have described the significance of viral respiratory infections (VRIs) in exacerbation of asthma in adult patients. The aim of this study was to elucidate the profiles of VRIs in adult patients with asthma along with their molecular epidemiology.A cross-sectional observational study was conducted at Kyorin University Hospital from August 2012 to May 2015. To identify respiratory pathogens in inpatients and outpatients suffering from asthma attacks, RT-PCR/sequencing/phylogenetic analysis methods were applied alongside conventional microbiological methods...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048927/early-origins-of-asthma-role-of-microbial-dysbiosis-and-metabolic-dysfunction
#18
Fernando D Martinez, Stefano Guerra
Asthma is a developmental disease that affects airway growth and is characterized by inappropriate responses to a variety of environmental stimuli. Recent advances point to two altered early life pathways as major determinants of asthma risk. In the "microbial" pathway, pre- and post-natal exposures to microbiota-loaded farm environments block gene-virus interactions (e.g., interactions between risk alleles in chromosome 17q21 and lower respiratory illnesses [LRI] by rhinovirus) that are associated with asthma development...
October 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29045416/neonatal-immune-response-to-rhinovirus-a16-has-diminished-dendritic-cell-function-and-increased-b-cell-activation
#19
Amanda Barlow-Anacker, Yury Bochkov, James Gern, Christine M Seroogy
BACKGROUND: Rhinovirus infections during infancy account for the majority of respiratory illness health care utilization and are an associated risk factor for subsequent development of allergic asthma. Neonatal type I interferon production is diminished compared to adults after stimulation with TLR agonists. However, broad profiling of immune cell responses to infectious rhinovirus has not been undertaken and we hypothesized that additional immune differences can be identified in neonates...
2017: PloS One
https://www.readbyqxmd.com/read/29042873/comparison-of-cytokine-expression-profiles-in-infants-with-a-rhinovirus-induced-lower-respiratory-tract-infection-with-or-without-wheezing-a-comparison-with-respiratory-syncytial-virus
#20
Da Eun Roh, Sook-Hyun Park, Hee Joung Choi, Yeo Hyang Kim
PURPOSE: The aim of this study was to evaluate whether infants with rhinovirus (RV) infection-induced wheezing and those with respiratory syncytial virus (RSV) infection-induced wheezing have different cytokine profiles in the acute stage. METHODS: Of the infants with lower respiratory tract infection (LRTI) between September 2011 and May 2012, 88 were confirmed using reverse transcription polymerase chain reaction and hospitalized. Systemic interferon-gamma (IFN-γ), interleukin (IL)-2, IL-12, IL-4, IL-5, IL-13, and Treg-type cytokine (IL-10) responses were examined with multiplex assay using acute phase serum samples...
September 2017: Korean Journal of Pediatrics
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