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Innate lymphoid cells

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https://www.readbyqxmd.com/read/28219179/-function-and-modulation-of-type-%C3%A2-innate-lymphoid-cells-and-their-role-in-chronic-upper-airway-inflammatory-diseases
#1
Y Liu, Z Liu
Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, such as asthma and atopic dermatitis, and also play a very important role in the metabolic balance. In addition, recent reports suggest that ILC2 not only play a role in the initial stages of the disease, but also can lead to chronic pathological changes in the disease, such as fibrosis, and may have an effect on acquired immunity...
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28217945/innate-lymphoid-cells-sparking-inflammatory-rheumatic-disease
#2
REVIEW
Mark H Wenink, Emmerik F A Leijten, Tom Cupedo, Timothy R D J Radstake
No abstract text is available yet for this article.
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28216436/group-2-innate-lymphoid-cell-activation-in-the-neonatal-lung-drives-type-2-immunity-and-allergen-sensitization
#3
Catherine A Steer, Itziar Martinez-Gonzalez, Maryam Ghaedi, Patricia Allinger, Laura Mathä, Fumio Takei
Neonatal lung immunity is unique due to allergen-independent endogenous IL-33 mediated activation of group 2 innate lymphoid cells (ILC2s) that promote Th2 cell responses, making neonates prone to allergen sensitization and allergic lung diseases.
February 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28213354/a-population-of-innate-lymphoid-cells-impairs-til-expansion-in-hgsc
#4
(no author information available yet)
Regulatory CD56(+)CD3(-) innate lymphoid cells (ILC) suppress tumor-infiltrating lymphocyte (TIL) expansion.
February 17, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28212158/an-integrated-understanding-of-the-immunology-of-allograft-inflammation
#5
Brenna Houlihan, Priscilla Cha, Michael Zasloff, Thomas M Fishbein, Alexander Kroemer
PURPOSE OF REVIEW: The purpose of this review is to summarize recent advances in our understanding of the complex immunology of intestinal transplantation and allograft rejection. RECENT FINDINGS: Recent findings highlight the importance of the intestinal microbiome for intestinal homeostasis and the role of newly discovered innate lymphoid cells in intestinal transplantation. In addition, the role of host antimicrobial Th17 responses in the pathogenesis of inflammatory bowel diseases and intestinal allograft rejection has been further elucidated...
February 15, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28209996/transient-cannabinoid-receptor-2-blockade-during-immunization-heightens-intensity-and-breadth-of-antigen-specific-antibody-responses-in-young-and-aged-mice
#6
Emmanuel Dotsey, Irina Ushach, Egest Pone, Rie Nakajima, Algis Jasinskas, Donovan A Argueta, Andrea Dillon, Nicholas DiPatrizio, Huw Davies, Albert Zlotnik, Peter D Crompton, Philip L Felgner
The hallmark of vaccines is their ability to prevent the spread of infectious pathogens and thereby serve as invaluable public health tool. Despite their medical relevance, there is a gap in our understanding of the physiological factors that mediate innate and adaptive immune response to vaccines. The endocannabinoid (eCB) system is a critical modulator of homeostasis in vertebrates. Our results indicate that macrophages and dendritic cells produce the endocannabinoid, 2-arachidonoyl-sn-glycerol (2-AG) upon antigen activation...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28199847/neuropilin-1-is-expressed-on-lymphoid-tissue-residing-lti-like-group-3-innate-lymphoid-cells-and-associated-with-ectopic-lymphoid-aggregates
#7
Medya Mara Shikhagaie, Åsa K Björklund, Jenny Mjösberg, Jonas S Erjefält, Anne S Cornelissen, Xavier Romero Ros, Suzanne M Bal, Jasper J Koning, Reina E Mebius, Michiko Mori, Melanie Bruchard, Bianca Blom, Hergen Spits
Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1(+) group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1(+) ILC3s are mainly located in proximity to high endothelial venules (HEVs) and express cell surface molecules involved in lymphocyte migration in secondary lymphoid tissues via HEVs. NRP1 was also expressed on mouse fetal LTi cells, indicating that NRP1 is a conserved marker for LTi cells...
February 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28199345/impact-of-chronic-rhinosinusitis-on-severe-asthma-patients
#8
Ta-Jen Lee, Chia-Hsiang Fu, Chun-Hua Wang, Chi-Che Huang, Chien-Chia Huang, Po-Hung Chang, Yi-Wei Chen, Chia-Chen Wu, Ching-Lung Wu, Han-Pin Kuo
Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract ILC2s corresponding to enhanced IL-25, IL-33 and TSLP release in severe asthmatics, and be involved in asthma control. Twenty-eight asthmatics (12 non-severe and 16 severe) with CRS receiving nasal surgery were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28191880/single-cell-gene-expression-using-multiplex-rt-qpcr-to-characterize-heterogeneity-of-rare-lymphoid-populations
#9
Thibaut Perchet, Sylvestre Chea, Milena Hasan, Ana Cumano, Rachel Golub
Gene expression heterogeneity is an interesting feature to investigate in lymphoid populations. Gene expression in these cells varies during cell activation, stress, or stimulation. Single-cell multiplex gene expression enables the simultaneous assessment of tens of genes(1)(,)(2)(,)(3). At the single-cell level, multiplex gene expression determines population heterogeneity(4)(,)(5). It allows for the distinction of population heterogeneity by determining both the probable mix of diverse precursor stages among mature cells and also the diversity of cell responses to stimuli...
January 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28185161/the-skin-as-a-route-of-allergen-exposure-part-i-immune-components-and-mechanisms
#10
REVIEW
Anna R Smith, George Knaysi, Jeffrey M Wilson, Julia A Wisniewski
PURPOSE OF REVIEW: To highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen. RECENT FINDINGS: Defects in skin barrier function in infancy set the stage for the development of atopic dermatitis (AD) and allergy. Both genetic and environmental factors can contribute to damage of the stratum corneum (SC), with activation of specific protease enzymes under high pH conditions playing a key role. Immune cells and mediators in the dermis and epidermis impair SC repair mechanisms and support allergy development...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28179507/intestinal-commensal-bacteria-mediate-lung-mucosal-immunity-and-promote-resistance-of-newborn-mice-to-infection
#11
Jerilyn Gray, Katherine Oehrle, George Worthen, Theresa Alenghat, Jeffrey Whitsett, Hitesh Deshmukh
Immature mucosal defenses contribute to increased susceptibility of newborn infants to pathogens. Sparse knowledge of age-dependent changes in mucosal immunity has hampered improvements in neonatal morbidity because of infections. We report that exposure of neonatal mice to commensal bacteria immediately after birth is required for a robust host defense against bacterial pneumonia, the leading cause of death in newborn infants. This crucial window was characterized by an abrupt influx of interleukin-22 (IL-22)-producing group 3 innate lymphoid cells (IL-22(+)ILC3) into the lungs of newborn mice...
February 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28179442/t-helper-cell-type-2-th2-and-non-th2-molecular-phenotypes-of-asthma-using-sputum-transcriptomics-in-u-biopred
#12
Chih-Hsi Scott Kuo, Stelios Pavlidis, Matthew Loza, Fred Baribaud, Anthony Rowe, Iaonnis Pandis, Ana Sousa, Julie Corfield, Ratko Djukanovic, Rene Lutter, Peter J Sterk, Charles Auffray, Yike Guo, Ian M Adcock, Kian Fan Chung
Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from 104 moderate-to-severe asthmatic subjects and 16 nonasthmatic subjects.After filtering on the differentially expressed genes between eosinophil- and noneosinophil-associated sputum inflammation, we used unbiased hierarchical clustering on 508 differentially expressed genes and gene set variation analysis of specific gene sets.We defined three transcriptome-associated clusters (TACs): TAC1 (characterised by immune receptors IL33R, CCR3 and TSLPR), TAC2 (characterised by interferon-, tumour necrosis factor-α- and inflammasome-associated genes) and TAC3 (characterised by genes of metabolic pathways, ubiquitination and mitochondrial function)...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28177259/radiation-induced-dermatitis-is-mediated-by-il17-expressing-%C3%AE-%C3%AE-t-cells
#13
Wupeng Liao, Tom K Hei, Simon K Cheng
Radiation dermatitis is a serious cutaneous injury caused by radiation therapy or upon accidental nuclear exposure. However, the pathogenic immune mechanisms underlying this injury are still poorly understood. We seek to discover how the dysregulated immune response after irradiation orchestrates skin inflammation. The skin on the left flank of C57BL/6J wild-type and C57BL/6J Tcrd(-/-) mice, which are deficit in γδ T cells, was exposed to a single X-ray dose of 25 Gy, and the right-flank skin was used as a sham-irradiated control...
February 8, 2017: Radiation Research
https://www.readbyqxmd.com/read/28172423/p060-role-of-innate-lymphoid-cells-in-the-chronic-colitis-under-anti-il-17a-therapy
#14
C S Eun, D S Han, C H Park, A R Lee, Y R Lee
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28165478/a-distinct-innate-lymphoid-cell-population-regulates-tumor-associated-t-cells
#15
Sarah Q Crome, Linh T Nguyen, Sandra Lopez-Verges, S Y Cindy Yang, Bernard Martin, Jennifer Y Yam, Dylan J Johnson, Jessica Nie, Michael Pniak, Pei Hua Yen, Anca Milea, Ramlogan Sowamber, Sarah Rachel Katz, Marcus Q Bernardini, Blaise A Clarke, Patricia A Shaw, Philipp A Lang, Hal K Berman, Trevor J Pugh, Lewis L Lanier, Pamela S Ohashi
Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56(+)CD3(-) population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production...
February 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28164850/biology-of-the-microbiome-1-interactions-with-the-host-immune-response
#16
REVIEW
Sylwia Smolinska, David Groeger, Liam O'Mahony
The intestinal immune system is intimately connected with the vast diversity of microbes present within the gut and the diversity of food components that are consumed daily. The discovery of novel molecular mechanisms, which mediate host-microbe-nutrient communication, have highlighted the important roles played by microbes and dietary factors in influencing mucosal immune responses. Dendritic cells, epithelial cells, innate lymphoid cells, T regulatory cells, effector lymphocytes, natural killer T cells, and B cells can all be influenced by the microbiome...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28160290/regulatory-t-cells-and-type-2-innate-lymphoid-cell-dependent-asthma
#17
REVIEW
Jennifer L Aron, Omid Akbari
Group two innate lymphoid cells (ILC2s) are a recently identified group of cells with the potent capability to produce Th2-type cytokines such as interleukin (IL)-5 and IL-13. Several studies suggest that ILC2s play an important role in the development of allergic diseases and asthma. Activation of pulmonary ILC2s in murine models lacking T and B cells induces eosinophilia and airway hyperreactivity (AHR), which are cardinal features of asthma. More importantly, numerous recent studies have highlighted the role of ILC2s in asthma persistence and exacerbation among human subjects and thus, regulation of pulmonary ILC2s is a major area of investigation aimed at curbing allergic lung inflammation and exacerbation...
February 4, 2017: Allergy
https://www.readbyqxmd.com/read/28154198/il-33-mediated-expansion-of-type-2-innate-lymphoid-cells-protects-from-progressive-glomerulosclerosis
#18
Jan-Hendrik Riedel, Martina Becker, Kerstin Kopp, Mathis Düster, Silke R Brix, Catherine Meyer-Schwesinger, Luis A Kluth, Ann-Christin Gnirck, Madena Attar, Sonja Krohn, Boris Fehse, Rolf A K Stahl, Ulf Panzer, Jan-Eric Turner
Innate lymphoid cells (ILCs) have an important role in the immune system's response to different forms of infectious and noninfectious pathologies. In particular, IL-5- and IL-13-producing type 2 ILCs (ILC2s) have been implicated in repair mechanisms that restore tissue integrity after injury. However, the presence of renal ILCs in humans has not been reported. In this study, we show that ILC populations are present in the healthy human kidney. A detailed characterization of kidney-residing ILC populations revealed that IL-33 receptor-positive ILC2s are a major ILC subtype in the kidney of humans and mice...
February 2, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28148916/innate-lymphoid-cells-in-autoimmunity-emerging-regulators-in-rheumatic-diseases
#19
REVIEW
Medya M Shikhagaie, Kristine Germar, Suzanne M Bal, Xavier Romero Ros, Hergen Spits
Innate lymphoid cells (ILCs) are important in the regulation of barrier homeostasis. These cells do not express T cell receptors but share many functional similarities with T helper cells and cytotoxic CD8(+) T lymphocytes. ILCs are divided into three groups, namely group 1 ILCs, group 2 ILCs and group 3 ILCs, based on the transcription factors they depend on for their development and function, and the cytokines they produce. Emerging data indicate that ILCs not only have protective functions but can also have detrimental effects when dysregulated, leading to chronic inflammation and autoimmune diseases, including asthma, inflammatory bowel disease, graft-versus-host disease, psoriasis, rheumatoid arthritis and atopic dermatitis...
February 2, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28146477/feedback-control-of-ahr-signalling-regulates-intestinal-immunity
#20
Chris Schiering, Emma Wincent, Amina Metidji, Andrea Iseppon, Ying Li, Alexandre J Potocnik, Sara Omenetti, Colin J Henderson, C Roland Wolf, Daniel W Nebert, Brigitta Stockinger
The aryl hydrocarbon receptor (AHR) recognizes xenobiotics as well as natural compounds such as tryptophan metabolites, dietary components and microbiota-derived factors, and it is important for maintenance of homeostasis at mucosal surfaces. AHR activation induces cytochrome P4501 (CYP1) enzymes, which oxygenate AHR ligands, leading to their metabolic clearance and detoxification. Thus, CYP1 enzymes have an important feedback role that curtails the duration of AHR signalling, but it remains unclear whether they also regulate AHR ligand availability in vivo...
February 9, 2017: Nature
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