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Innate lymphoid cells

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https://www.readbyqxmd.com/read/29223298/innate-lymphoid-cells-and-allergic-disease
#1
REVIEW
Matthew T Stier, R Stokes Peebles
No abstract text is available yet for this article.
December 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29222107/il-33-promotes-the-egress-of-group-2-innate-lymphoid-cells-from-the-bone-marrow
#2
Matthew T Stier, Jian Zhang, Kasia Goleniewska, Jacqueline Y Cephus, Mark Rusznak, Lan Wu, Luc Van Kaer, Baohua Zhou, Dawn C Newcomb, R Stokes Peebles
Group 2 innate lymphoid cells (ILC2s) are effector cells within the mucosa and key participants in type 2 immune responses in the context of allergic inflammation and infection. ILC2s develop in the bone marrow from common lymphoid progenitor cells, but little is known about how ILC2s egress from the bone marrow for hematogenous trafficking. In this study, we identified a critical role for IL-33, a hallmark peripheral ILC2-activating cytokine, in promoting the egress of ILC2 lineage cells from the bone marrow...
December 8, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29221580/mechanisms-of-allergen-immunotherapy-for-inhaled-allergens-and-predictive-biomarkers
#3
REVIEW
Mohamed H Shamji, Stephen R Durham
Allergen immunotherapy is effective in patients with IgE-dependent allergic rhinitis and asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical benefit for several years after its discontinuation. This disease-modifying effect is both antigen-specific and antigen-driven. Clinical improvement is accompanied by decreases in numbers of effector cells in target organs, including mast cells, basophils, eosinophils, and type 2 innate lymphoid cells. Immunotherapy results in the production of blocking IgG/IgG4 antibodies that can inhibit IgE-dependent activation mediated through both high-affinity IgE receptors (FcεRI) on mast cells and basophils and low-affinity IgE receptors (FcεRII) on B cells...
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29217133/pge2-suppresses-human-group-2-innate-lymphoid-cell-function
#4
Jovana Maric, Avinash Ravindran, Luca Mazzurana, Åsa K Björklund, Aline Van Acker, Anna Rao, Danielle Friberg, Sven-Erik Dahlén, Akos Heinemann, Viktoria Konya, Jenny Mjösberg
BACKGROUND: Group 2 innate lymphoid cells (ILC2) are involved in the initial phase of type 2 inflammation and can amplify allergic immune responses by orchestrating other type 2 immune cells. PGE2 is a bioactive lipid that plays protective roles in the lung, particularly during allergic inflammation. OBJECTIVE: We set out to investigate how PGE2 regulates human ILC2 function. METHODS: The effects of PGE2 on human ILC2 proliferation, intracellular cytokine and transcription factor expression were assessed by flow cytometry...
December 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29209568/phenotype-and-tissue-distribution-of-cd28h-immune-cell-subsets
#5
Joel Crespo, Linda Vatan, Tomasz Maj, Rebecca Liu, Ilona Kryczek, Weiping Zou
CD28H is a newly discovered co-receptor of the human B7 family. CD28H interacts with its ligand B7-H5 and regulates T cell response. Here we showed that CD28H was not expressed on granulocytes, monocytes, myeloid dendritic cells (MDCs), and B cells, but constitutively expressed with moderate levels on memory T cells and with high levels on naïve T cells, innate lymphoid cells (ILCs), natural killer (NK) cells, and plasmacytoid dendritic cells (PDCs) in human peripheral blood. Similar CD28H+ cell profile existed in secondary lymphoid organs and pathological tissues including multiple types of cancers...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29206103/a-population-of-innate-myelolymphoblastoid-effector-cell-expanded-by-inactivation-of-mtor-complex-1-in-mice
#6
Fei Tang, Peng Zhang, Peiying Ye, Christopher A Lazarski, Qi Wu, Ingrid L Bergin, Timothy P Bender, Michael N Hall, Ya Cui, Liguo Zhang, Taijiao Jiang, Yang Liu, Pan Zheng
Adaptive autoimmunity is restrained by controlling population sizes and pathogenicity of harmful clones, while innate destruction is controlled at effector phase. We report here that deletion of Rptor in mouse hematopoietic stem/progenitor cells causes self-destructive innate immunity by massively increasing the population of previously uncharacterized innate myelolymphoblastoid effector cells (IMLECs). Mouse IMLECs are CD3-B220-NK1.1-Ter119- CD11clow/-CD115-F4/80low/-Gr-1- CD11b+, but surprisingly express high levels of PD-L1...
December 5, 2017: ELife
https://www.readbyqxmd.com/read/29205464/interleukin-17-family-cytokines-in-protective-immunity-against-infections-role-of-hematopoietic-cell-derived-and-non-hematopoietic-cell-derived-interleukin-17s
#7
REVIEW
Goro Matsuzaki, Masayuki Umemura
Interleukin (IL)-17 family cytokines consisting of six members participate in immune response in infections, autoimmune diseases and inflammatory diseases. The prototype cytokine of the family, IL-17A, was originally identified from CD4+ T cells which are now termed Th17. Later IL-17A-producing cells are expanded to various hematopoietic cells including CD8+ T cells (Tc17), invariant NKT cells, γ δ T cells, non-T non-B lymphocytes termed type 3 innate lymphoid cells (ILC3), and neutrophils. Some members of the IL-17 family cytokines other than IL-17A were also expressed by CD4+ T cells: IL-17E by Th2 cells, and IL-17F by Th17 cells...
December 2, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29204051/intestinal-epithelium-intraepithelial-lymphocytes-and-the-gut-microbiota-key-players-in-the-pathogenesis-of-celiac-disease
#8
REVIEW
Bożena Cukrowska, Agnieszka Sowińska, Joanna Beata Bierła, Elżbieta Czarnowska, Anna Rybak, Urszula Grzybowska-Chlebowczyk
Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens (HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29203226/innately-versatile-%C3%AE-%C3%AE-17%C3%A2-t-cells-in-inflammatory-and-autoimmune-diseases
#9
REVIEW
Pedro H Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
IL-17-producing γδ (γδ17) T cells form a versatile subset of cells that respond rapidly to innate stimuli and support the pro-inflammatory functions of different myeloid and lymphoid lineages, being particularly critical in the early stages of inflammatory and autoimmune responses. In mice, under homeostatic conditions, these innate-like lymphocytes are pre-programmed in the fetal thymus, through an intricate process involving both T cell receptor-dependent and -independent signals, which allows them to readily produce IL-17 upon stimulation...
December 1, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29202803/emerging-mechanisms-and-novel-targets-in-allergic-inflammation-and-asthma
#10
Scott T Weiss
Airway inflammation is key to the severity and persistence of asthma. Recent studies have revealed novel immune mechanisms that target dendritic cells, T helper 2 cytokines, regulatory T cells, and type 2 innate lymphoid cells in allergic inflammation, as well as novel approaches that target airway smooth muscle in asthma. These advances inform the development of new targeted treatments for allergic inflammation and asthma with the potential to provide therapeutic benefit.
December 4, 2017: Genome Medicine
https://www.readbyqxmd.com/read/29202042/relative-impact-of-complement-receptors-cd21-35-cr2-1-on-scrapie-pathogenesis-in-mice
#11
Sarah J Kane, Eric Swanson, Elizabeth O Gordon, Savannah Rocha, Heather R Bender, Luke R Donius, Adriano Aguzzi, Jonathan P Hannan, Mark D Zabel
Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs). CD21 helps activate B cells as part of the B cell coreceptor with CD19 and CD81. Differential splicing of transcripts from the mouse Cr2 gene generates isoforms with both shared and unique complement binding capacities and cell-type expression. In mouse models, genetic depletion of Cr2 causes either a delay or complete prevention of prion disease, but the relative importance of CD35 versus CD21 in promoting prion disease remains unknown...
November 2017: MSphere
https://www.readbyqxmd.com/read/29201028/shaping-innate-lymphoid-cell-diversity
#12
REVIEW
Qiutong Huang, Cyril Seillet, Gabrielle T Belz
Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation. We present here the most recent understanding of how genomics has provided significant insight into how ILCs are generated and the enormous heterogeneity present within the canonical subsets. This has allowed the generation of a detailed blueprint for ILCs to become highly sensitive and adaptive sensors of environmental changes and therefore exquisitely equipped to protect immune surfaces...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29198601/a-short-field-guide-to-fibroblast-function-in-immunity
#13
REVIEW
Matthew B Buechler, Shannon J Turley
Fibroblasts in secondary lymphoid organs, or fibroblastic reticular cells (FRC), are gate-keepers of immune responses. Here, we frame how these cells regulate immune responses via a three-part scheme in which FRC can setup, support or suppress immune responses. We also review how fibroblasts from non-lymphoid tissues influence immunity and highlight how they resemble and differ from FRC. Overall, we aim to focus attention on the emerging roles of lymphoid tissue and non-lymphoid tissue fibroblasts in control of innate and adaptive immunity...
November 30, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29196657/alternative-activation-generates-il-10-producing-type-2-innate-lymphoid-cells
#14
Corey R Seehus, Asha Kadavallore, Brian de la Torre, Alyson R Yeckes, Yizhou Wang, Jie Tang, Jonathan Kaye
Type 2 innate lymphoid cells (ILC2) share cytokine and transcription factor expression with CD4+ Th2 cells, but functional diversity of the ILC2 lineage has yet to be fully explored. Here, we show induction of a molecularly distinct subset of activated lung ILC2, termed ILC210. These cells produce IL-10 and downregulate some pro-inflammatory genes. Signals that generate ILC210 are distinct from those that induce IL-13 production, and gene expression data indicate that an alternative activation pathway leads to the generation of ILC210...
December 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29196207/inflammation-and-fibrosis
#15
REVIEW
Matthias Mack
Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue damage not only induces inflammation in general, it also determines the type and polarization of inflammation by recruiting and activating a variety of different cells types of the innate and adaptive immune system. This review focuses on the pathways leading from tissue damage to inflammation, from inflammation to fibrosis and from fibrosis to function. It covers the pro- and antifibrotic properties of immunological mediators released from T cells, monocytes/macrophages, innate lymphoid cells, basophils and eosinophils and takes into account that extracellular matrix proteins are not only produced by mesenchymal fibroblasts but also by infiltrating hematopoietic cells...
November 28, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29194733/activity-of-group-2-innate-lymphoid-cells-is-associated-with-chronic-inflammation-and-dysregulated-metabolic-homeostasis-in-type-2-diabetic-nephropathy
#16
Ping Lu, Xiaoyun Ji, Jie Wan, Huaxi Xu
The metabolic syndrome (MS) is an independent risk factor for type 2 diabetic nephropathy, and accompanied by subclinical inflammation which involves immune-deriving factors. Emerging studies indicate that ILC2s can regulate adipose metabolism, but much less is known about the activity of ILC2s in metabolic imbalance in obesity and diabetes. The present study explored the effect of ILC2s-related molecules on the occurrence of metabolic syndrome in type 2 diabetic nephropathy. Thirty patients with type 2 diabetic nephropathy were included in the study, the mRNA expression of ILC2s associated molecules from peripheral blood mononuclear cell and the correlation of the ILC2s activity and the metabolic syndrome related indicators were analyzed...
December 1, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29194124/humanized-mouse-models-to-study-pathophysiology-and-treatment-of-hiv-infection
#17
Guillemette Masse-Ranson, Hugo Mouquet, James P Di Santo
PURPOSE OF REVIEW: Immunodeficient mice that lack all lymphocyte subsets and have phagocytic cells that are tolerant of human cells can be stably xenografted with human hematopoietic stem cell as well as other human tissues (fetal liver and thymus) creating 'human immune system' (HIS) mice. HIS mice develop all major human lymphocyte classes (B, T, natural killer, and innate lymphoid cell) and their specialized subsets as well as a variety of myeloid cells (dendritic cell, monocytes, and macrophages) thereby providing a small animal model in which to interrogate human immune responses to infection...
November 30, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29192833/cytometric-gating-stringency-impacts-studies-of-type-2-innate-lymphoid-cells-in-asthma
#18
Timothy S C Hinks, Paul Batty, Paul Klenerman, Ian D Pavord, Luzheng Xue
No abstract text is available yet for this article.
December 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29186686/testosterone-attenuates-group-2-innate-lymphoid-cell-mediated-airway-inflammation
#19
Jacqueline-Yvonne Cephus, Matthew T Stier, Hubaida Fuseini, Jeffrey A Yung, Shinji Toki, Melissa H Bloodworth, Weisong Zhou, Kasia Goleniewska, Jian Zhang, Sarah L Garon, Robert G Hamilton, Vasiliy V Poloshukin, Kelli L Boyd, R Stokes Peebles, Dawn C Newcomb
Sex hormones regulate many autoimmune and inflammatory diseases, including asthma. As adults, asthma prevalence is 2-fold greater in women compared to men. The number of group 2 innate lymphoid cells (ILC2) is increased in patients with asthma, and we investigate how testosterone attenuates ILC2 function. In patients with moderate to severe asthma, we determine that women have an increased number of circulating ILC2 compared to men. ILC2 from adult female mice have increased IL-2-mediated ILC2 proliferation versus ILC2 from adult male mice, as well as pre-pubescent females and males...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29184556/gata3-regulates-the-development-and-functions-of-innate-lymphoid-cell-subsets-at-multiple-stages
#20
REVIEW
Jinfang Zhu
Innate lymphoid cells (ILCs) are regarded as the innate counterpart of effector CD4 T helper (Th) cells. Just as Th cells, ILCs are classified into distinct subsets based on their functions that are delivered mainly through effector cytokine production. Both ILCs and Th cells play critical roles in various protective immune responses and inflammatory diseases. Similar to Th cell differentiation, the development of ILC subsets depends on several master transcription factors, among which GATA3 is critical for the development and maintenance of type 2 ILCs (ILC2s)...
2017: Frontiers in Immunology
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