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Innate lymphoid cells

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https://www.readbyqxmd.com/read/29046031/-innate-lymphoid-cells-and-their-role-in-immune-response-regulation
#1
Bibiana Patricia Ruiz-Sánchez, David Cruz-Zárate, Iris Estrada-García, Isabel Wong-Baeza
Innate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and in chronic inflammatory conditions. ILCs are divided in ILC-1, ILC-2 and ILC-3, and these cells have analogue functions to those of immune adaptive response lymphocytes Th1, Th2 and Th17. ILC-1 express T-bet, produce IFNγ, protect against infections with intracellular microorganisms and are related to inflammatory bowel disease immunopathology...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045903/hpari-protein-secreted-by-a-helminth-parasite-suppresses-interleukin-33
#2
Megan Osbourn, Dinesh C Soares, Francesco Vacca, E Suzanne Cohen, Ian C Scott, William F Gregory, Danielle J Smyth, Matilda Toivakka, Andrea M Kemter, Thierry le Bihan, Martin Wear, Dennis Hoving, Kara J Filbey, James P Hewitson, Holly Henderson, Andrea Gonzàlez-Cìscar, Claire Errington, Sonja Vermeren, Anne L Astier, William A Wallace, Jürgen Schwarze, Alasdair C Ivens, Rick M Maizels, Henry J McSorley
Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045900/molecular-and-functional-characterization-of-lymphoid-progenitor-subsets-reveals-a-bipartite-architecture-of-human-lymphopoiesis
#3
Kutaiba Alhaj Hussen, Thien-Phong Vu Manh, Fabien Guimiot, Elisabeth Nelson, Emna Chabaane, Marc Delord, Maxime Barbier, Claire Berthault, Nicolas Dulphy, Antonio José Alberdi, Odile Burlen-Defranoux, Gerard Socié, Jean Christophe Bories, Jerôme Larghero, Valérie Vanneaux, Els Verhoeyen, Thierry Wirth, Marc Dalod, Jean Claude Gluckman, Ana Cumano, Bruno Canque
The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127(-) and CD127(+) early lymphoid progenitors (ELPs). Combining molecular analyses with in vitro and in vivo functional assays, we demonstrated that CD127(-) and CD127(+) ELPs emerged independently from lympho-mono-dendritic progenitors, responded differently to Notch1 signals, underwent divergent modes of lineage restriction, and displayed both common and specific differentiation potentials...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045847/cross-tissue-transcriptomic-analysis-of-human-secondary-lymphoid-organ-residing-ilc3s-reveals-a-quiescent-state-in-the-absence-of-inflammation
#4
Yotam E Bar-Ephraim, Ferry Cornelissen, Natalie Papazian, Tanja Konijn, Remco M Hoogenboezem, Mathijs A Sanders, Bart A Westerman, Mehmet Gönültas, Jaap Kwekkeboom, Joke M M Den Haan, Rogier M Reijmers, Reina E Mebius, Tom Cupedo
A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue transcriptomic approach to compare human ILC3s from non-inflamed lymph nodes and spleen to their phenotypic counterparts in inflamed tonsils and from circulation. These analyses revealed that, in the absence of inflammation, lymphoid organ-residing ILC3s lack transcription of cytokines associated with classical ILC3 functions...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29042669/rna-editing-by-adar1-regulates-innate-and-antiviral-immune-functions-in-primary-macrophages
#5
Maria Pujantell, Eva Riveira-Muñoz, Roger Badia, Marc Castellví, Edurne Garcia-Vidal, Guillem Sirera, Teresa Puig, Cristina Ramirez, Bonaventura Clotet, José A Esté, Ester Ballana
ADAR1-dependent A-to-I editing has recently been recognized as a key process for marking dsRNA as self, therefore, preventing innate immune activation and affecting the development and resolution of immune-mediated diseases and infections. Here, we have determined the role of ADAR1 as a regulator of innate immune activation and modifier of viral susceptibility in primary myeloid and lymphoid cells. We show that ADAR1 knockdown significantly enhanced interferon, cytokine and chemokine production in primary macrophages that function as antiviral paracrine factors, rendering them resistant to HIV-1 infection...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038474/a-shared-runx1-bound-zbtb16-enhancer-directs-innate-and-innate-like-lymphoid-lineage-development
#6
Ai-Ping Mao, Isabel E Ishizuka, Darshan N Kasal, Malay Mandal, Albert Bendelac
Zbtb16-encoded PLZF is a signature transcription factor (TF) that directs the acquisition of T-helper effector programs during the development of multiple innate lymphocyte lineages, including natural killer T cell, innate lymphoid cell, mucosal-associated invariant T cell and γδ lineages. PLZF is also essential in osteoblast and spermatogonial development. How Zbtb16 itself is regulated in different lineages is incompletely understood. Here, by systematic CRISPR/Cas9-assisted deletions of chromatin accessible regions within the Zbtb16 locus in mouse, we identify a critical enhancer controlling PLZF expression exclusively in innate lymphoid lineages...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29038009/advances-in-mechanisms-of-allergic-disease-in-2016
#7
Marc E Rothenberg, Hirohisa Saito, R Stokes Peebles
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; TH2 lymphocytes; eicosanoid regulation of inflammation; extracellular vesicles in allergic responses; IL-33; microbiome properties, especially as they relate to mucosal barrier function; and a series of findings concerning the allergic inflammatory cells eosinophils, basophils, and mast cells. During the last year, mechanistic advances occurred in understanding type 2 innate lymphoid cells, particularly related to their response to ozone, involvement with experimental food allergy responses, and regulation by IL-33...
October 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29038008/fibrinogen-cleavage-products-and-tlr4-promote-the-generation-of-programmed-cell-death-1-ligand-2-pd-l2-dendritic-cells-in-allergic-asthma
#8
Minkyoung Cho, Jeong-Eun Lee, Hoyong Lim, Hyun-Woo Shin, Roza Khalmuratova, Garam Choi, Hyuk Soon Kim, Wahn Soo Choi, Young-Jun Park, Inbo Shim, Byung-Seok Kim, Chang-Yuil Kang, Jae-Ouk Kim, Shinya Tanaka, Masato Kubo, Yeonseok Chung
BACKGROUND: Inhaled protease allergens preferentially trigger Th2-mediated inflammation in allergic asthma. The role of dendritic cells (DCs) on the induction of Th2 cell responses in allergic asthma has been well documented; however, the mechanism by which protease allergens induce Th2-favorable DCs in the airway remains unclear. OBJECTIVE: We sought to determine a subset of DCs responsible for Th2 cell responses in allergic asthma and the mechanism by which protease allergens induce the DC subset in the airway...
October 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29036021/the-role-of-innate-lymphoid-cells-in-airway-inflammation-evolving-paradigms
#9
Inge Kortekaas Krohn, Suzanne M Bal, Korneliusz Golebski
PURPOSE OF REVIEW: Innate lymphoid cells (ILCs) act as early orchestrators of the immune response, tissue repair, and maintenance of barrier homeostasis. This review summarizes recent findings of the role of ILCs in airway disease and highlights ongoing developments in clinical applications and treatment options. RECENT FINDINGS: On the basis of the transcription factors required for their development and cytokine profiles, ILCs have been classified into three subsets that resemble those of T-helper subtypes...
October 13, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29032487/pathological-and-therapeutic-roles-of-innate-lymphoid-cells-in-diverse-diseases
#10
REVIEW
Jisu Kim, Geon Kim, Hyeyoung Min
Innate lymphoid cells (ILCs) are a recently defined type of innate-immunity cells that belong to the lymphoid lineage and have lymphoid morphology but do not express an antigen-specific B cell or T-cell receptor. ILCs regulate immune functions prior to the formation of adaptive immunity and exert effector functions through a cytokine release. ILCs have been classified into three groups according to the transcription factors that regulate their development and function and the effector cytokines they produce...
October 14, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29030488/long-lived-innate-il-17-producing-%C3%AE-%C3%AE-t-cells-modulate-antimicrobial-epithelial-host-defense-in-the-colon
#11
Abdul Rashid Bin Mohammad Muzaki, Irene Soncin, Yolanda Aphrilia Setiagani, Jianpeng Sheng, Piotr Tetlak, Klaus Karjalainen, Christiane Ruedl
Intestinal IL-17-producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17-producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minimal turnover. Most colon γ/δ T17 cells express, together with Vγ4 and CCR6, the scavenger receptor 2 and are mainly restricted to innate lymphoid follicles in the colon. Colon γ/δ T cells in mice that lack conventional dendritic cells 2 produced increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as the C-type lectins Reg3γ and Reg3β...
October 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29029958/innate-lymphoid-cell-regulation-meeting-the-long-lost-cousin
#12
Matthew R Hepworth
Innate lymphoid cells (ILCs) play critical roles in immune homeostasis and immunity to pathogens. Increasing evidence implicates dysregulated ILC responses as drivers of disease pathogenesis in multiple inflammatory disorders. A recent study reveals how inflammatory ILC responses can be suppressed by a newly defined subset of ILCs with regulatory function.
October 10, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/29018444/mucosa-associated-lymphoid-tissue-lymphoma-translocation-protein-1-positively-modulates-matrix-metalloproteinase-9-production-in-alveolar-macrophages-upon-toll-like-receptor-7-signaling-and-influenza-virus-infection
#13
Yu-Hsiang Lee, Juin-Hua Huang, Tzu-Hsuan Chang, Hung-Chih Yang, Betty A Wu-Hsieh
Influenza A virus (IAV) infection causes significant morbidity and mortality worldwide. Matrix metalloproteinase-9 (MMP-9) degrades extracellular matrix and is involved in the pathology of influenza. It has been reported that MMP-9 mediates neutrophil migration in IAV infection. Whether alveolar macrophages, the first immune cells that encounter IAV, produce MMP-9, and the mechanism of its regulation have never been investigated. As Toll-like receptor 7 (TLR7) is one of the receptors in innate immune cells that recognize IAV, we used TLR7 agonists and IAV to stimulate alveolar macrophage MH-S cells, primary macrophages, and bone marrow neutrophils...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29018148/suppression-of-cyp1-members-of-the-ahr-response-by-pathogen-associated-molecular-patterns
#14
Adam G Peres, Robert Zamboni, Irah L King, Joaquín Madrenas
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that triggers a broad response, which includes the regulation of proinflammatory cytokine production by monocytes and macrophages. AHR is negatively regulated by a set of genes that it transcriptionally activates, including the AHR repressor (Ahrr) and the cytochrome P450 1 (Cyp1) family, which are critical for preventing exacerbated AHR activity. An imbalance in these regulatory mechanisms has been shown to cause severe defects in lymphoid cells...
October 10, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28993779/natural-killer-cell-response-to-chemotherapy-stressed-cancer-cells-role-in-tumor-immunosurveillance
#15
REVIEW
Alessandra Zingoni, Cinzia Fionda, Cristiana Borrelli, Marco Cippitelli, Angela Santoni, Alessandra Soriani
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance. An equilibrium between immune control and tumor growth is maintained as long as cancer cells evade immunosurveillance. Therapies designed to kill cancer cells and to simultaneously sustain host antitumor immunity are an appealing strategy to control tumor growth. Several chemotherapeutic agents, depending on which drugs and doses are used, give rise to DNA damage and cancer cell death by means of apoptosis, immunogenic cell death, or other forms of non-apoptotic death (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28986418/cd169-macrophages-orchestrate-innate-immune-responses-by-regulating-bacterial-localization-in-the-spleen
#16
Oriana A Perez, Stephen T Yeung, Paola Vera-Licona, Pablo A Romagnoli, Tasleem Samji, Basak B Ural, Leigh Maher, Masato Tanaka, Kamal M Khanna
The spleen is an important site for generating protective immune responses against pathogens. After infection, immune cells undergo rapid reorganization to initiate and maintain localized inflammatory responses; however, the mechanisms governing this spatial and temporal cellular reorganization remain unclear. We show that the strategic position of splenic marginal zone CD169(+) macrophages is vital for rapid initiation of antibacterial responses. In addition to controlling initial bacterial growth, CD169(+) macrophages orchestrate a second phase of innate protection by mediating the transport of bacteria to splenic T cell zones...
October 6, 2017: Science Immunology
https://www.readbyqxmd.com/read/28983810/dysregulation-of-innate-lymphoid-cells-in-common-variable-immunodeficiency
#17
REVIEW
Paul J Maglione, Montserrat Cols, Charlotte Cunningham-Rundles
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immune deficiency. With widespread use of immunoglobulin replacement therapy, non-infectious complications, such as autoimmunity, chronic intestinal inflammation, and lung disease, have replaced infections as the major cause of morbidity and mortality in this immune deficiency. The pathogenic mechanisms that underlie the development of these complications in CVID are not known; however, there have been numerous associated laboratory findings...
October 5, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28982732/adenosine-receptors-differentially-regulate-type-2-cytokine-production-by-il-33-activated-bone-marrow-cells-ilc2s-and-macrophages
#18
Balázs Csóka, Zoltán H Németh, Claudia U Duerr, Jörg H Fritz, Pál Pacher, György Haskó
Group 2 innate lymphoid cells (ILC2s) represent a rapid source of type 2 cytokines, such as IL-5 and IL-13, and play an important role in orchestrating type 2 immune response. Adenosine is an endogenous purine nucleoside, a catabolite of ATP that binds and activates ≥1 of 4 transmembrane G protein-coupled cell-surface adenosine receptors (ARs)-A1, A2A, A2B, and A3 Here, we studied the role of ARs in the regulation of cytokine production by ILC2s. We found that A2BARs suppress the production of both IL-5 and IL-13 by ILC2s, whereas A2AARs augment IL-5 production and fail to affect IL-13 release...
October 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28972206/regulation-of-immunity-and-inflammation-by-hypoxia-in-immunological-niches
#19
REVIEW
Cormac T Taylor, Sean P Colgan
Immunological niches are focal sites of immune activity that can have varying microenvironmental features. Hypoxia is a feature of physiological and pathological immunological niches. The impact of hypoxia on immunity and inflammation can vary depending on the microenvironment and immune processes occurring in a given niche. In physiological immunological niches, such as the bone marrow, lymphoid tissue, placenta and intestinal mucosa, physiological hypoxia controls innate and adaptive immunity by modulating immune cell proliferation, development and effector function, largely via transcriptional changes driven by hypoxia-inducible factor (HIF)...
October 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28969116/natural-killer-cells-their-role-in-tumour-immunosurveillance
#20
REVIEW
Preeti Sharma, Pradeep Kumar, Rachna Sharma
An important component of the innate immune system, the natural killer cells that originate from the lymphoid cell lineage, hold tremendous potential as an effective therapeutic tool to combat a variety of cancers. Their vast capability to kill altered cells such as opsonized cells (antibody coated), tumour cells, genotoxically changed cells without affecting the healthy cells of the body, make them an effective therapeutic agent for various types of cancers. Besides, through interplay and molecular crosstalk via several cytokines, they also augment the adaptive immune response by, promoting the differentiation, activation and recruitment of component cells of the system...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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