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https://www.readbyqxmd.com/read/29676620/interleukin-13-stimulation-reveals-the-cellular-and-functional-plasticity-of-the-airway-epithelium
#1
Max A Seibold
About 50% of patients with asthma exhibit chronic airway inflammation driven by the type 2 cytokines interleukin (IL)-4, IL-5, and IL-13. These patients with type 2-high asthma experience more allergic symptoms, greater airway hyperresponsiveness, and more severe mucus obstruction than patients with type 2-low asthma. Mouse models of asthma have shown that much of the airway dysfunction in these models can be generated by IL-13 stimulation of the airway epithelium alone. Both in vivo mouse model studies and in vitro studies of human mucociliary airway epithelial cultures have shown that IL-13 induces cellular remodeling of the airway epithelium through proliferation-independent transdifferentiation processes...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676073/overexpression-of-mir-155-5p-inhibits-the-proliferation-and-migration-of-il-13-induced-human-bronchial-smooth-muscle-cells-by-suppressing-tgf-%C3%AE-activated-kinase-1-map3k7-binding-protein-2
#2
Yujia Shi, Xingli Fu, Qi Cao, Zhengdao Mao, Yi Chen, Yun Sun, Zhiguang Liu, Qian Zhang
PURPOSE: Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease remains unknown. The present study was designed to uncover the probable involvement of miR-155-5p in the proliferation and migration of IL-13-induced human bronchial smooth muscle cells (BSMCs) and the intrinsic regulatory mechanism. METHODS: The effects of different concentrations of IL-13 on the proliferation and migration of BSMCs as well as the expression of miR-155-5p and its predicted target transforming growth factor (TGF)-β-activated kinase 1/MAP3K7-binding protein 2 (TAB2) were investigated...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29676068/trpv1-blocking-alleviates-airway-inflammation-and-remodeling-in-a-chronic-asthma-murine-model
#3
Joon Young Choi, Hwa Young Lee, Jung Hur, Kyung Hoon Kim, Ji Young Kang, Chin Kook Rhee, Sook Young Lee
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1 (TRPV1) channel in the pathophysiology of asthma. This study examined whether TRPV1 antagonism alleviates asthma features in a murine model of chronic asthma. METHODS: BALB/c mice were sensitized to and challenged by ovalbumin to develop chronic asthma...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675435/serum-levels-of-interleukin-13-increase-in-subjects-with-insulin-resistance-but-do-not-correlate-with-markers-of-low-grade-systemic-inflammation
#4
Camilo P Martínez-Reyes, Angélica Y Gómez-Arauz, Israel Torres-Castro, Aarón N Manjarrez-Reyna, León F Palomera, Alfonso Olivos-García, Edith Mendoza-Tenorio, Gabriela A Sánchez-Medina, Sergio Islas-Andrade, Guillermo Melendez-Mier, Galileo Escobedo
Experimental evidence in mice suggests a role for interleukin- (IL-) 13 in insulin resistance and low-grade systemic inflammation. However, IL-13 serum levels have not been assessed in subjects with insulin resistance, and associations of IL-13 with parameters of low-grade systemic inflammation are still unknown. Our main goal was to examine the systemic levels of IL-13 in patients with insulin resistance, while also studying the relationship of IL-13 with anthropometric, metabolic, and low-grade systemic inflammatory markers...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29673285/tlr-agonist-combinations-that-stimulate-th-type-i-polarizing-responses-from-human-neonates
#5
Naveen Surendran, Andrea Simmons, Michael E Pichichero
Each year millions of neonates die due to vaccine preventable infectious diseases. Our study seeks to develop novel neonatal vaccines and improve immunogenicity of early childhood vaccines by incorporating TLR agonist-adjuvant combinations that overcome the inherent neonatal Th2 bias and stimulate Th1 polarizing response from neonatal APCs. We systematically stimulated cord blood mononuclear cells with single and multiple combinations of TLR agonists and measured levels of IL-12p70, IFN-γ, IFN-α, IL-10, IL-13, TNF-α, IL-6 and IL-1β from cell culture supernatants...
January 1, 2018: Innate Immunity
https://www.readbyqxmd.com/read/29672593/il-13-induces-periostin-and-eotaxin-expression-in-human-primary-alveolar-epithelial-cells-comparison-with-paired-airway-epithelial-cells
#6
Yoko Ito, Reem Al Mubarak, Nicole Roberts, Kelly Correll, William Janssen, James Finigan, Rangnath Mishra, Hong Wei Chu
Alveolar epithelial cells are critical to the pathogenesis of pulmonary inflammation and fibrosis, which are associated with overexpression of type 2 cytokine IL-13. IL-13 is known to induce the production of profibrotic (e.g., periostin) and pro-inflammatory (e.g., eotaxin-3) mediators in human airway epithelial cells, but it remains unclear if human primary alveolar epithelial cells increase periostin and eotaxin expression following IL-13 stimulation. The goals of this study are to determine if alveolar epithelial cells increase periostin and eotaxin expression upon IL-13 stimulation, and if alveolar and airway epithelial cells from the same subjects have similar responses to IL-13...
2018: PloS One
https://www.readbyqxmd.com/read/29671891/the-association-of-circulating-inflammation-proteins-and-gallstone-disease
#7
Zhiwei Liu, Troy J Kemp, Yu-Tang Gao, Amanda Corbel, Emma E McGee, Bingsheng Wang, Ming-Chang Shen, Asif Rashid, Ann W Hsing, Allan Hildesheim, Ruth M Pfeiffer, Ligia A Pinto, Jill Koshiol
BACKGROUND: Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones. METHODS: We measured 13 cytokines (including 10 interleukins), that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. We estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders...
April 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29671873/t-cell-derived-ifn-%C3%AE-downregulates-protective-group-2-innate-lymphoid-cells-in-murine-lupus-erythematosus
#8
Mathis Düster, Martina Becker, Ann-Christin Gnirck, Malte Wunderlich, Ulf Panzer, Jan-Eric Turner
Innate lymphoid cells (ILCs) are important regulators of the immune response and play a crucial role in the restoration of tissue homeostasis after injury. GATA-3+ IL-13- and IL-5-producing group 2 innate lymphoid cells (ILC2s) have been shown to promote tissue repair in barrier organs, but despite extensive research on ILCs in the recent years, their potential role in autoimmune diseases is still incompletely understood. In the present study, we investigate the role of ILC2s in the MRL/MpJ-Faslpr (MRL-lpr) mouse model for severe organ manifestation of systemic lupus erythematosus (SLE)...
April 19, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29671652/effects-of-educated-monocytes-with-xenogeneic-mesenchymal-stem-cell-derived-conditioned-medium-in-a-mouse-model-of-chronic-asthma
#9
Hadi Esmaili Gourvarchin Galeh, Seyyed Meysam Abtahi Froushani, Nahideh Afzale Ahangaran, Siamak Naji Hadai
BACKGROUND: This study was conducted to determine the potential of the monocytes educated with rat bone marrow mesenchymal stem cell-derived conditioned medium (MCM) in ameliorating animal model of asthma. METHODS: Chronic asthma was induced in the BALB/c mice using ovalbumin (OVA) sensitization. The monocytes were isolated from blood of mice and supplemented with 50% MCM or negative control media. After 24 h, the cells were designated as "non-educated or educated"...
April 19, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29670614/human-v%C3%AE-9v%C3%AE-2-t-cells-synergize-cd4-t-follicular-helper-cells-to-produce-influenza-virus-specific-antibody
#10
Qingyun Chen, Kun Wen, Aizhen Lv, Ming Liu, Ke Ni, Zheng Xiang, Yinping Liu, Wenwei Tu
Human Vγ9Vδ2-T cells recognize nonpeptidic antigens and exert effector functions against microorganisms and tumors, but little is known about their roles in humoral immune response against influenza virus infection. Herein, in the coculture of autologous human B cells, dendritic cells and/or naïve CD4 T cells, and Vγ9Vδ2-T cells, we demonstrated that Vγ9Vδ2-T cells could facilitate H9N2 influenza virus-specific IgG and IgM productions in a CD4 T cell-dependent manner. Vγ9Vδ2-T cells promoted the differentiation of CXCR5+ PD1+ CD4+ T follicular helper (Tfh) cells, CD19+ IgD- CD38++ plasma cells (PCs), and drove B cell proliferation as well as immunoglobulin class switching...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670467/trail-dependent-resolution-of-pulmonary-fibrosis
#11
David M Habiel, Ana Paula Moreira, Ugur B Ismailoglu, Michael P Dunleavy, Karen A Cavassani, Nico van Rooijen, Ana Lucia Coelho, Cory M Hogaboam
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling. In the present study, the expression of tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) was key to the resolution of bleomycin-induced pulmonary fibrosis. Both in vivo and in vitro studies demonstrated that Gr-1+ TRAIL+ bone marrow-derived myeloid cells blocked the activation of lung myofibroblasts...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29670225/il-13-may-be-involved-in-the-development-of-cad-via-different-mechanisms-under-different-conditions-in-a-chinese-han-population
#12
Ling-Feng Zha, Shao-Fang Nie, Qian-Wen Chen, Yu-Hua Liao, Hong-Song Zhang, Jiang-Tao Dong, Tian Xie, Fan Wang, Ting-Ting Tang, Ni Xia, Cheng-Qi Xu, Ying-Chao Zhou, Zhi-Peng Zeng, Jiao Jiao, Peng-Yun Wang, Qing K Wang, Xin Tu, Xiang Cheng
Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457C -rs2069744T -rs20541A ) significantly contributed to the risk of CAD with adjusted p values less than 0...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670037/expression-and-regulation-of-thymic-stromal-lymphopoietin-and-thymic-stromal-lymphopoietin-receptor-heterocomplex-in-the-innate-adaptive-immunity-of-pediatric-asthma
#13
REVIEW
Sheng-Chieh Lin, Fang-Yi Cheng, Jun-Jen Liu, Yi-Ling Ye
Asthma is a chronic inflammatory disease affecting the airway, and it is characterized by a wheezing breathing sound, variable airflow obstruction and the presence of inflammatory cells in the submucosa of the bronchi. Viral infection, pollutants and sensitivity to aeroallergens damage the epithelium from childhood, which causes asthma. The pathogenesis of asthma includes pathways of innate stimulation by environmental microbes and irritant pathogens. Damaged epithelial cells produce thymic stromal lymphopoietin (TSLP) and stimulate myeloid dendritic cell maturation through the thymic stromal lymphopoietin receptor (TSLPR) heterocomplex...
April 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29669943/whole-exome-sequencing-uncovers-oxidoreductases-dhtkd1-and-ogdhl-as-linkers-between-mitochondrial-dysfunction-and-eosinophilic-esophagitis
#14
Joseph D Sherrill, Kiran Kc, Xinjian Wang, Ting Wen, Adam Chamberlin, Emily M Stucke, Margaret H Collins, J Pablo Abonia, Yanyan Peng, Qiang Wu, Philip E Putnam, Phillip J Dexheimer, Bruce J Aronow, Leah C Kottyan, Kenneth M Kaufman, John B Harley, Taosheng Huang, Marc E Rothenberg
Eosinophilic esophagitis (EoE) is an allergic inflammatory esophageal disorder with a complex underlying genetic etiology often associated with other comorbidities. Using whole-exome sequencing (WES) of 63 patients with EoE and 60 unaffected family members and family-based trio analysis, we sought to uncover rare coding variants. WES analysis identified 5 rare, damaging variants in dehydrogenase E1 and transketolase domain-containing 1 (DHTKD1). Rare variant burden analysis revealed an overabundance of putative, potentially damaging DHTKD1 mutations in EoE (P = 0...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29667773/benzyl-isothiocyanate-attenuates-the-hydrogen-peroxide-induced-interleukin-13-expression-through-glutathione-s-transferase-p-induction-in-t-lymphocytic-leukemia-cells
#15
Yue Tang, Sho Naito, Naomi Abe-Kanoh, Seiji Ogawa, Shu Yamaguchi, Beiwei Zhu, Yoshiyuki Murata, Yoshimasa Nakamura
We investigated the effect of benzyl isothiocyanate (BITC) on the hydrogen peroxide-induced gene expression of a T-helper-2 cytokine, interleukin (IL)-13, in T lymphocytic leukemia Jurkat cells. The 24-h pretreatment of BITC significantly inhibited the IL-13 expression enhanced by hydrogen peroxide. Although the BITC pretreatment did not change the enhanced level of the phosphorylated c-Jun N-terminal kinase (JNK), it significantly inhibited the nuclear translocation of c-Jun induced by hydrogen peroxide. BITC also increased the protein expression of glutathione S-transferase (GST) isozymes, GSTP1/2, as well as the total GST activity...
April 18, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29665659/suppressive-effect-of-4-hydroxy-2-4-hydroxyphenethyl-isoindoline-1-3-dione-on-ovalbumin-induced-allergic-asthma
#16
Jin Huang, Mingzhi Su, Bo-Kyung Lee, Mee-Jeong Kim, Jee H Jung, Dong-Soon Im
4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione (PD1) is a synthetic phthalimide derivative of a marine compound. PD1 has peroxisome proliferator-activated receptor (PPAR) γ agonistic and anti-inflammatory effects. This study aimed to investigate the effect of PD1 on allergic asthma using rat basophilic leukemia (RBL)-2H3 mast cells and an ovalbumin (OVA)-induced asthma mouse model. In vitro , PD1 suppressed β-hexosaminidase activity in RBL-2H3 cells. In the OVA-induced allergic asthma mouse model, increased inflammatory cells and elevated Th2 and Th1 cytokine levels were observed in bronchoalveolar lavage fluid (BALF) and lung tissue...
April 18, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29665497/the-effects-of-resiquimod-in-an-ovalbumin-induced-allergic-rhinitis-model
#17
Shenhong Qu, Taijie Qin, Min Li, Shaojie Zhang, Linsong Ye, Jiazhang Wei, Hua Fan, Baiwen Chen
Growing evidence indicates that the Toll-like receptor7/8(TLR7/8) agonist resiquimod (R848) is a potential inhibitor of type-2 immunity. However, the mechanisms mediating its therapeutic effects are not fully understood. This study investigated the effects of R848 on OVA-induced allergic rhinitis(AR) mice and the expression of IL-25, IL-33, TSLP, T-cell immunoglobulin mucin1 (TIM1) and T-cell immunoglobulin mucin3 (TIM3). BALB/c mice were intranasally sensitized and challenged with ovalbumin (OVA), and R848 was intraperitoneally injected into AR mice...
April 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29665312/interleukin-13-associates-with-life-threatening-rhinovirus-infections-in-infants-and-young-children
#18
Mauricio T Caballero, Diego R Hijano, Patricio L Acosta, Cecilia G Mateu, Débora N Marcone, Jodell E Linder, Laura B Talarico, John M Elder, Marcela Echavarria, Eva Kathryn Miller, Fernando P Polack
OBJECTIVE: Delineate risk factors associated with severe hypoxemia (O2 sat ≤87%) in infants and children younger than 2 years hospitalized with single pathogen HRV infection. STUDY DESIGN: Prospective study in a yearly catchment population of 56 560 children <2 years old between 2011 and 2013 in Argentina. All children with respiratory signs and O2 sat <93% on admission were included. HRV infections were identified by reverse transcriptase-polymerase chain reaction...
April 17, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29662488/subretinal-injection-of-hy-peptides-induces-systemic-antigen-specific-inhibition-of-effector-cd4-and-cd8-t-cell-responses
#19
Julie Vendomèle, Safa Dehmani, Quentin Khebizi, Anne Galy, Sylvain Fisson
Purpose: Injection of an antigen into the anterior chamber of the eye induces a peripheral antigen-specific immune modulation mechanism, known as anterior chamber-associated immune deviation (ACAID). Delayed-type hypersensitivity experiments argue that the subretinal space (SR) of the eye displays properties similar to ACAID. However, no investigation was performed regarding the differential impact of a subretinal antigen injection on peripheral CD4+ versus CD8+ T cells, on the potential immune deviation regarding Th profiles, and on the antigen-specificity of the inhibition...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29660515/aspergillus-fumigatus-viability-drives-allergic-responses-to-inhaled-conidia
#20
Ajay P Nayak, Tara L Croston, Angela R Lemons, W T Goldsmith, Nikki B Marshall, Michael L Kashon, Dori R Germolec, Donald H Beezhold, Brett J Green
BACKGROUND: Aspergillus fumigatus induced allergic airway disease has been shown to involve conidial germination in vivo but the immunological mechanisms remain uncharacterized. OBJECTIVE: A subchronic murine exposure model was used to examine the immunological mediators that are regulated in response to either culturable or non-culturable A. fumigatus conidia. METHODS: Female B6C3F1/N mice were repeatedly dosed via inhalation with 1 x 105 viable or heat inactivated conidia (HIC), twice a week for 13 weeks (26 exposures)...
April 13, 2018: Annals of Allergy, Asthma & Immunology
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