Junpeng Zhao, Yi Chen, Liming Li, Huiqi Yin, Shasha Song, Yongfang Wang, Xiwei Feng, Xinyu Fan, Changxing Gao, Lingyu Gao, Yijing Zhan, Ming Zhao, Xinyu Li, Qianjin Lu
Cysteinyl leukotriene receptor 1 (CYSLTR1) is observed to increase in psoriatic skin lesions. Montelukast, a CYSLTR1 antagonist, effectively treats inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, and atopic dermatitis. Thus, blocking CYSLTR1 may be a promising strategy for psoriasis immunotherapy. We prepared a montelukast sodium cream and solution and investigated their effects on psoriasis-like skin lesions induced by imiquimod (IMQ). After the treatment, serum, skin, and spleen samples were collected for evaluation...
2024: International Journal of Biological Sciences