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https://www.readbyqxmd.com/read/29665364/casticin-inhibits-pdgf-induced-proliferation-and-migration-of-airway-smooth-muscle-cells
#1
Ying Dai, Ruiduo Cheng, Jie Gao, Ying Li, Chunyan Lou, Yanyang Li
Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone), one of the main components from Vitex rotundifolia L., was reported to possess several pharmacological properties, including anti-inflammatory, hepatoprotective, anticancer, anti-asthma activities. However, the effects of casticin on airway smooth muscle cells (ASMCs) proliferation and migration have not been explored. This study aimed to evaluate the effects of casticin on the proliferation and migration of ASMCs, and study the possible molecular mechanism...
April 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29663427/surfactant-protein-d-alleviates-eosinophil-mediated-airway-inflammation-and-remodeling-in-patients-with-aspirin-exacerbated-respiratory-disease
#2
Youngwoo Choi, Dong-Hyun Lee, Trinh Hoang Kim Tu, Ga-Young Ban, Hanki Park, Yoo Seob Shin, Seung-Hyun Kim, Hae-Sim Park
BACKGROUND: Surfactant protein D (SPD) is a member of the collectin family that lines the airway epithelial cells with host defense. However, the role of SPD in the pathogenesis of aspirin-exacerbated respiratory disease (AERD) is still unclear. METHODS: The serum SPD level was measured in patients with AERD (n=336), those with aspirin-tolerant asthma (ATA, n=442), and healthy controls (HC, n=104). Polymorphisms of SFTPD in the study subjects were analyzed. The effect of LTE4 on SPD production through eosinophil infiltration was investigated in BALB/c mice...
April 16, 2018: Allergy
https://www.readbyqxmd.com/read/29651473/microfluidic-lung-airway-on-a-chip-with-arrayable-suspended-gels-for-studying-epithelial-and-smooth-muscle-cell-interactions
#3
Mouhita Humayun, Chung-Wai Chow, Edmond W K Young
Chronic lung diseases (CLDs) are regulated by complex interactions between many different cell types residing in lung airway tissues. Specifically, interactions between airway epithelial cells (ECs) and airway smooth muscle cells (SMCs) have been shown in part to play major roles in the pathogenesis of CLDs, but the underlying molecular mechanisms are not well understood. To advance our understanding of lung pathophysiology and accelerate drug development processes, new innovative in vitro tissue models are needed that can reconstitute the complex in vivo microenvironment of human lung tissues...
April 13, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29649811/transcription-elongation-factor-p-tefb-is-involved-in-il-17f-signaling-in-airway-smooth-muscle-cells
#4
Masayuki Nakajima, Mio Kawaguchi, Masashi Matsuyama, Kyoko Ota, Junichi Fujita, Satoshi Matsukura, Shau-Ku Huang, Yuko Morishima, Yukio Ishii, Hiroaki Satoh, Tohru Sakamoto, Nobuyuki Hizawa
BACKGROUND: IL-17F is involved in the pathogenesis of several inflammatory diseases, including asthma and COPD. However, the effects of steroids on the function of IL-17F signaling mechanisms are largely unknown. One of the transcription elongation factors, positive transcription elongation factor b (P-TEFb) composed of cyclin T1 and cyclin-dependent kinase 9 (CDK9), is known as a novel checkpoint regulator of gene expression via bromodomain-containing protein 4 (Brd4). METHODS: Human airway smooth muscle cells were stimulated with IL-17F and the expression of IL-8 was evaluated by real-time PCR and ELISA...
April 12, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29628047/increased-expression-of-cyslt-2-receptors-in-the-lung-of-asthmatic-mice-and-role-in-allergic-responses
#5
Masaya Matsuda, Yuki Tabuchi, Kazuma Nishimura, Yuri Nakamura, Tomohiko Sekioka, Michiaki Kadode, Kazuhito Kawabata, Takeshi Nabe
Compared with CysLT1 receptors, the functional role of CysLT2 receptors in asthma has not been clarified. The purpose of this study was to determine 1) whether CysLT2 receptors are expressed in the lung of mice and if expression increases in asthmatic mice, and 2) whether CysLT2 receptors are involved in allergic leukocyte infiltration into the lung and in the development of airway remodeling in asthmatic mice. BALB/c mice were sensitized with ovalbumin (OVA) + Al(OH)3 , and intratracheally challenged with OVA 4 times...
April 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29626716/pharmacological-mechanisms-leading-to-synergy-in-fixed-dose-dual-bronchodilator-therapy
#6
REVIEW
Luigino Calzetta, Maria Gabriella Matera, Mario Cazzola
Long-acting β2 adrenoceptor agonists (LABAs) in combination with long-acting muscarinic antagonists (LAMAs) can elicit functional and clinical benefits in chronic obstructive pulmonary disease (COPD). LABA/LAMA combinations synergistically relax human isolated airways at the level of the medium and small bronchi. LABAs and LAMAs both modulate the bronchial tone via different pathways localized at the level of presynaptic parasympathetic fibers and airway smooth muscle cells. The exact nature of the interactions between these pathways is not completely understood, but there is cross-talk at many levels in airway smooth muscle cells that is also regulated by the activity of calcium-activated potassium channels and protein tyrosine kinases...
April 4, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29624776/trpc3-overexpression-and-intervention-in-airway-smooth-muscle-of-ovalbumin-induced-hyperresponsiveness-and-remodeling
#7
Bo-Ming Xu, Jia-Hua Zhang, Jia-Ling Wang, Jun-Hua Xiao
Transient receptor potential canonical channel 3 (TRPC3) proteins function as non-voltage-gated Ca2+ -permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression and airway hyperresponsiveness and remodeling in ovalbumin-induced asthmatic Kunming mice. Mice were sensitized and challenged by ovalbumin to establish asthmatic model. Hematoxylin-eosin staining, hydroxyproline assay and isometric tracheal ring force measurement were used to evaluate airway remodeling and hyperresponsiveness in asthmatic mice...
April 6, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29621420/regulation-of-eosinophil-recruitment-and-allergic-airway-inflammation-by-heparan-sulfate-proteoglycan-hspg-modifying-enzymes
#8
Xiao Na Ge, Idil Bastan, Sung Gil Ha, Yana G Greenberg, Jeffrey D Esko, Savita P Rao, P Sriramarao
BACKGROUND: HSPGs are glycoproteins containing covalently attached heparan sulfate (HS) chains which bind to growth factors, chemokines, etc., and regulate various aspects of inflammation including cell recruitment. We previously showed that deletion of endothelial N-acetylglucosamine N-deacetylase-N-sulfotransferase-1 (Ndst1), an enzyme responsible for N-sulfation during HS biosynthesis, reduces allergic airway inflammation (AAI). Here, we investigated the importance of O-sulfation mediated by uronyl 2-O-sulfotransferase (Hs2st) in development of AAI relative to N-sulfation...
April 5, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29616842/the-discovery-and-development-of-aclidinium-bromide-for-the-treatment-of-chronic-obstructive-pulmonary-disease
#9
Mario Malerba, Alessandro Radaeli, Giuseppe Santini, Jaymin Morjaria, Nadia Mores, Chiara Mondino, Giuseppe Macis, Paolo Montuschi
Bronchodilators, including long-acting muscarinic receptor antagonists (LAMAs), are a mainstay of the pharmacological treatment of chronic obstructive pulmonary disease (COPD). LAMAs act as bronchodilators principally by antagonizing airway smooth muscle cells M3 muscarinic receptors. Aclidinium bromide is a twice-daily LAMA which was developed to improve on the efficacy and/or safety of previous LAMAs. Area covered: Herein, the authors present the pharmacotherapeutic role of aclidinium in COPD and point out unmet need in this research area...
April 4, 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29604964/selective-inhibition-of-histamine-evoked-ca-2-signals-by-compartmentalized-camp-in-human-bronchial-airway-smooth-muscle-cells
#10
Philippa Dale, Victoria Head, Mark R Dowling, Colin W Taylor
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease. However, the interactions between different G protein-coupled receptors (GPCRs) that evoke cAMP and Ca2+ signals in human bronchial airway smooth muscle cells (hBASMCs) are poorly understood. We measured Ca2+ signals in cultures of fluo-4-loaded hBASMCs alongside measurements of intracellular cAMP using mass spectrometry or [3 H]-adenine labeling...
May 2018: Cell Calcium
https://www.readbyqxmd.com/read/29603800/remodeling-and-inflammation-in-preschoolers-with-severe-recurrent-wheeze-and-asthma-outcome-at-school-age
#11
Guillaume Lezmi, Antoine Deschildre, Rola Abou Taam, Michael Fayon, Sylvain Blanchon, Françoise Troussier, Philippe Mallinger, Bruno Mahut, Philippe Gosset, Jacques de Blic
BACKGROUND: The influence of airway remodeling and inflammation in preschoolers with severe recurrent wheeze on asthma outcomes is poorly understood. OBJECTIVE: To assess their association with asthma symptoms and lung function at school age. METHODS: Preschoolers (38.4 months) initially investigated with bronchial biopsies were re-assessed for asthma symptoms and lung function at school age. RESULTS: Thirty six of 49 preschoolers (73...
March 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29600901/pde8-a-novel-target-in-airway-smooth-muscle
#12
Haoxiao Zuo, Martina Schmidt, Reinoud Gosens
No abstract text is available yet for this article.
April 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29600050/-pten-gene-silencing-contributes-to-airway-remodeling-and-induces-airway-smooth-muscle-cell-proliferation-in-mice-with-allergic-asthma
#13
Xin Wen, Jing Yan, Xin-Rui Han, Gui-Hong Zheng, Ran Tang, Li-Fang Liu, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
Background: Allergic asthma is a complex genetic disorder that involves interactions between genetic and environmental factors. Usage of PTEN may be a good therapeutic strategy for the management of allergic inflammation. Thus, the present study aims to explore the effects of phosphatase and tensin homolog ( PTEN ) gene silencing on airway remodeling and proliferation of airway smooth muscle cells (ASMCs) in a mouse model of allergic asthma. Methods: A total of 56 healthy female BABL/c mice (weighing between 16 to 22 grams) were selected and were assigned on random into ovalbumin (OVA; mice were stimulated with OVA to induce allergic asthma), OVA + si-PTEN, normal saline (NS; mice were treated with normal saline) and NS + si-PTEN groups...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29587542/effects-of-maternal-folic-acid-supplementation-on-airway-remodeling-and-allergic-airway-disease-development
#14
Burcin İscan, Funda Tuzun, Berna Eroglu Filibeli, Serap Cilekar Micili, Bekir Ugur Ergur, Nuray Duman, Hasan Ozkan, Abdullah Kumral
OBJECTIVE: Maternal folic acid supplementation has been recommended prior to and during the first trimester of pregnancy to reduce the risk of infant neural tube defects. However, an uncertain relationship between folic acid supplementation during pregnancy and development of childhood asthma exists. Recent data show a methyl donor-rich diet could increase the risk of developing allergic airway disease through DNA methylation and aberrant gene transcription. This study evaluated the effect of folic acid supplementation during pregnancy on airway remodeling and allergic airway disease vulnerability in a mouse asthma model...
March 27, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29582435/combining-long-acting-bronchodilators-with-different-mechanisms-of-action-a-pharmacological-approach-to-optimize-bronchodilation-of-equine-airways
#15
L Calzetta, P Rogliani, E Pistocchini, M Mattei, G Cito, P Alfonsi, C Page, M G Matera
The ultra long-acting β2 -adrenoceptor agonist olodaterol plus the ultra long-acting muscarinic antagonist tiotropium bromide are known to relax equine airways. In human bronchi combining these drugs elicits a positive interaction, thus we aimed to characterize this information further in equine isolated airways stimulated by electrical field stimulation (EFS) and using the Concentration-Reduction Index (CRI) and Combination Index (CI) equations. The drugs were administered alone and together by reproducing ex vivo the concentration-ratio delivered by the currently available fixed-dose combination (1:1)...
March 26, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29578347/a-novel-orally-available-asthma-drug-candidate-that-reduces-smooth-muscle-constriction-and-inflammation-by-targeting-gaba-a-receptors-in-the-lung
#16
Gloria S Forkuo, Amanda N Nieman, Revathi Kodali, Nicolas M Zahn, Guanguan Li, Shadiqur Rashid Roni, Michael Rajesh Stephen, Ted William Harris, Rajwana Jahan, Margaret L Guthrie, Olivia B Yu, Janet L Fisher, Gene T Yocum, Charles W Emala, Douglas A Steeber, Douglas C Stafford, James M Cook, Leggy A Arnold
We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α5β3γ2 selective GABA(A) receptor (GABA(A)R) modulators. MIDD0301 relaxed airway smooth muscle at single micromolar concentrations as demonstrated with ex vivo guinea pig tracheal rings. MIDD0301 also attenuated airway hyperresponsiveness (AHR) in an ovalbumin murine model of asthma by oral administration. Reduced numbers of eosinophils and macrophages were observed in mouse broncho-alveolar lavage fluid without changing mucous metaplasia...
March 26, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29577051/-aspergillus-fumigatus-infection-induced-neutrophil-recruitment-and-location-in-the-conducting-airway-of-immunocompetent-neutropenic-and-immunosuppressed-mice
#17
Marina A Shevchenko, Andrey O Bogorodskiy, Natalia I Troyanova, Ekaterina A Servuli, Elena L Bolkhovitina, Georg Büldt, Christoph Fahlke, Valentin I Gordeliy, Thomas Gensch, Valentin I Borshchevskiy, Alexander M Sapozhnikov
Susceptibility to fungal infection is commonly associated with impaired neutrophil responses. To study the mechanisms underlying this association, we investigated neutrophil recruitment to the conducting airway wall after Aspergillus fumigatus conidium inhalation in mouse models of drug-induced immunosuppression and antibody-mediated neutrophil depletion (neutropenia) by performing three-dimensional confocal laser-scanning microscopy of whole-mount primary bronchus specimens. Actin staining enabled visualization of the epithelial and smooth muscle layers that mark the airway wall...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29576747/cd38-cadpr-signaling-pathway-in-airway-disease-regulatory-mechanisms
#18
REVIEW
Deepak A Deshpande, Alonso G P Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F Walseth, Mathur S Kannan
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness. Inflammatory cytokines alter calcium (Ca2+ ) signaling and contractility of airway smooth muscle, which results in nonspecific airway hyperresponsiveness to agonists. In this context, Ca2+ regulatory mechanisms in airway smooth muscle and changes in these regulatory mechanisms encompass a major component of airway hyperresponsiveness...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29574924/the-effects-of-transient-receptor-potential-channel-trpc-on-airway-smooth-muscle-cell-isolated-from-asthma-model-mice
#19
Xiaoyu Zhang, Zhixin Zhao, Lijun Ma, Yali Guo, Xiaosu Li, Limin Zhao, Cuijie Tian, Xueyi Tang, Dongjun Cheng, Zhuochang Chen, Luoxian Zhang
This study aimed to validate whether transient receptor potential channel1 (TRPC1) and TRPC3 participate in the regulation the proliferation of airway smooth muscle cells (ASMCs) through modulating calcium ion (Ca2+ ) influx in vitro. Chronic model of murine asthma was induced and ASMCs isolated from asthmatic mice were used in this whole study. TRPC1 and TRPC3 were upregulated in asthmatic mouse ASMCs and selected for further investigation. Ca2+ concentration and the cell viability of asthmatic mouse ASMCs were significantly higher than that from non- asthma mice, however, TRPC channels blocker SKF96365 alleviated these effects...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29572536/dual-role-of-ym1-m2-macrophages-in-allergic-lung-inflammation
#20
Christina Draijer, Patricia Robbe, Carian E Boorsma, Machteld N Hylkema, Barbro N Melgert
Alternatively activated (M2 or YM1+) macrophages have been associated with the development of asthma but their contribution to disease initiation and progression remains unclear. To assess the therapeutic potential of modulating these M2 macrophages, we have studied inhibition of M2 polarisation during and after development of allergic lung inflammation by treating with cynaropicrin, a galectin-3 pathway inhibitor. Mice that were treated with this inhibitor of M2 polarisation during induction of allergic inflammation developed less severe eosinophilic lung inflammation and less collagen deposition around airways, while the airway α-smooth muscle actin layer was unaffected...
March 23, 2018: Scientific Reports
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