keyword
https://read.qxmd.com/read/38534776/the-influence-of-neurotrophins-on-the-brain-lung-axis-conception-pregnancy-and-neonatal-period
#1
REVIEW
Federica D'Amico, Cecilia Lugarà, Giovanni Luppino, Carlo Giuffrida, Ylenia Giorgianni, Eleonora Maria Patanè, Sara Manti, Antonella Gambadauro, Mariarosaria La Rocca, Tiziana Abbate
Neurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and smooth muscle) as well as some structural cells can secrete and respond to NTs...
March 15, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38529552/downregulation-of-protein-phosphatase-2a%C3%AE-in-asthmatic-airway-smooth-muscle
#2
JOURNAL ARTICLE
Mohammad Irshad Reza, Ashish Kumar, Christina M Pabelick, Rodney D Britt, Y S Prakash, Venkatachalem Sathish
Airway smooth muscle cell (ASM) is renowned for its involvement in airway hyperresponsiveness through impaired ASM relaxation and bronchoconstriction in asthma which poses a significant challenge in the field. Recent studies have explored different targets in ASM to alleviate airway hyperresponsiveness, however, a sizeable portion of asthmatics still experience poor control. In our study, we explored protein phosphatase 2A (PP2A) in ASM as it has been reported to regulate cellular contractility by controlling intracellular calcium ([Ca2+ ]i ), ion channels, and respective regulatory proteins...
March 26, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/38512807/kisspeptin-kiss1r-signaling-modulates-human-airway-smooth-muscle-cell-migration
#3
JOURNAL ARTICLE
Premanand Balraj, Nilesh Sudhakar Ambhore, Yogaraj S Ramakrishnan, Niyati A Borkar, Priyanka Banerjee, Mohammad Irshad Reza, Subashini Varadharajan, Ashish Kumar, Christina M Pabelick, Y S Prakash, Sathish Venkatachalem
Airway remodeling is a cardinal feature of asthma, associated with increased airway smooth muscle cell (ASM) mass and up-regulation of extracellular matrix deposition. Exaggerated ASM cell migration contributes to excessive ASM mass. Previously, we demonstrated the alleviating role of kisspeptin (Kp) receptor (KISS1R) activation by Kp-10 in mitogen (PDGF)-induced human ASM cell proliferation in vitro and airway remodeling in vivo in a mouse model of asthma. Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration...
March 21, 2024: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38512139/regional-variations-in-allergen-induced-airway-inflammation-correspond-to-changes-in-soluble-guanylyl-cyclase-heme-and-expression-of-heme-oxygenase-1
#4
JOURNAL ARTICLE
Mamta P Sumi, Rosemary Westcott, Eric Stuehr, Chaitali Ghosh, Dennis J Stuehr, Arnab Ghosh
Asthma is characterized by airway remodeling and hyperreactivity. Our earlier studies determined that the nitric oxide (NO)-soluble guanylyl cyclase (sGC)-cGMP pathway plays a significant role in human lung bronchodilation. However, this bronchodilation is dysfunctional in asthma due to high NO levels, which cause sGC to become heme-free and desensitized to its natural activator, NO. In order to determine how asthma impacts the various lung segments/lobes, we mapped the inflammatory regions of lungs to determine whether such regions coincided with molecular signatures of sGC dysfunction...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38501132/investigating-the-role-of-cftr-in-human-and-mouse-myometrium
#5
JOURNAL ARTICLE
Clodagh Prendergast, Susan Wray, Daniella Dungate, Christine Martin, Andra Vaida, Elizabeth Brook, Cecilia Ani Chioma, Helen Wallace
BACKGROUND: Abnormal cystic fibrosis transmembrane conductance regulator (CFTR) function in cystic fibrosis (CF) has been linked to airway smooth muscle abnormalities including bronchial hyperresponsiveness. However, a role for CFTR in other types of smooth muscle, including myometrium, remains largely unexplored. As CF life expectancy and the number of pregnancies increases, there is a need for an understanding of the potential role of CFTR in myometrial function. METHODS: We investigated the role of CFTR in human and mouse myometrium...
2024: Current research in physiology
https://read.qxmd.com/read/38500104/analysis-of-global-gene-expression-using-rna-sequencing-reveals-novel-mechanism-of-yanghe-pingchuan-decoction-in-the-treatment-of-asthma
#6
JOURNAL ARTICLE
Lingyu Pan, Bangfu He, Chunxia Gong, Yehong Sun, Xianchun Duan, Yanquan Han, Jijun Chu, Yongzhong Wang
BACKGROUND: Yanghe Pingchuan decoction (YPD) has been used for asthma treatment for many years in China. We sought to understand the mechanism of YPD, and find more potential targets for YPD-based treatment of asthma. METHODS: An ovalbumin-induced asthma model in rats was created. Staining (hematoxylin and eosin, Masson) was used to evaluate the treatment effect of YPD. RNA-sequencing was carried out to analyze global gene expression, and differentially expressed genes (DEGs) were identified...
March 18, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38495619/the-role-of-mitochondria-in-eosinophil-function-implications-for-severe-asthma-pathogenesis
#7
REVIEW
Janice Koranteng, Kian Fan Chung, Charalambos Michaeloudes, Pankaj Bhavsar
Mitochondria are key metabolic hubs involved in cellular energy production and biosynthesis. ATP is generated primarily by glucose and fatty acid oxidation through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in the mitochondria. During OXPHOS there is also production of reactive oxygen species (ROS), which are involved in the regulation of cellular function. Mitochondria are also central in the regulating cell survival and death, particularly in the intrinsic apoptosis pathway...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38492830/extracellular-acidification-attenuates-bronchial-contraction-via-an-autocrine-activation-of-ep-2-receptor-its-diminishment-in-murine-experimental-asthma
#8
JOURNAL ARTICLE
Yoshihiko Chiba, Yamato Yamane, Tsubasa Sato, Wataru Suto, Motohiko Hanazaki, Hiroyasu Sakai
PURPOSE: Extracellular acidification is a major component of tissue inflammation, including airway inflammation in asthmatics. However, its physiological/pathophysiological significance in bronchial function is not fully understood. Currently, the functional role of extracellular acidification on bronchial contraction was explored. METHODS: Left main bronchi were isolated from male BALB/c mice. Epithelium-removed tissues were exposed to acidic pH under submaximal contraction induced by 10-5 M acetylcholine in the presence or absence of a COX inhibitor indomethacin (10-6 M)...
March 14, 2024: Respiratory Physiology & Neurobiology
https://read.qxmd.com/read/38467504/effect-and-mechanism-of-acupuncture-on-airway-smooth-muscle-relaxation-during-acute-asthma-attack-in-rats
#9
JOURNAL ARTICLE
Yun Qiao, Yandi Liang, Shaoyuan Zhuo, Xuejie Yang, Tao Liang, Xi Ling, Qian Zhang, Yirong Shi, Wei Yi
OBJECTIVES: To explore the effect and mechanism of acupuncture at "Feishu" (BL 13) and "Dingchuan" (EX-B 1), and "Kongzui" (LU 6) and "Yuji" (LU 10) for relaxing the airway smooth muscle in the rats during acute asthma attack and compare the effect among the two pairs of acupoints and the acupoints combination. METHODS: Forty SD male rats with SPF grade were randomly divided into a blank group, a model group, a pair-point A group (acupuncture at "Feishu" [BL 13] and "Dingchuan" [EX-B 1]), a pair-point B group (acupuncture at "Kongzui" [LU 6] and "Yuji" [LU 10]) and a point combination group (acupuncture at "Feishu" [BL 13] , "Dingchuan" [EX-B 1], "Kongzui" [LU 6] and "Yuji" [LU 10]), with 8 rats in each group...
March 12, 2024: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/38458517/pm2-5-exposure-induced-senescence-associated-secretory-phenotype-in-airway-smooth-muscle-cells-contributes-to-airway-remodeling
#10
JOURNAL ARTICLE
Pei-Pei Cheng, Fan Yu, Shuai-Jun Chen, Xiao Feng, Zi-Heng Jia, Shi-He Hu, Xiao-Lin Cui, Ya-Ya Zhou, Qian Niu, Li-Mei Liang, Meng Wang, Lin-Jie Song, Xin-Liang He, Liang Xiong, Fei Xiang, Xiaorong Wang, Wan-Li Ma, Hong Ye
Fine particulate matter (PM2.5) has been linked to increased severity and incidence of airway diseases, especially chronic obstructive pulmonary disease (COPD) and asthma. Airway remodeling is an important event in both COPD and asthma, and airway smooth muscle cells (ASMCs) are key cells which directly involved in airway remodeling. However, it was unclear how PM2.5 affected ASMCs. This study investigates the effects of PM2.5 on airway smooth muscle and its mechanism. We first showed that inhaled particulate matter was distributed in the airway smooth muscle bundle, combined with increased airway smooth muscle bundle and collagen deposition in vivo...
March 6, 2024: Environmental Pollution
https://read.qxmd.com/read/38432633/rgs4-controls-airway-hyperresponsiveness-through-gap-independent-mechanisms
#11
JOURNAL ARTICLE
Ilin V Joshi, Eunice C Chan, Justin B Lack, Chengyu Liu, Kirk M Druey
Regulators of G protein signaling (RGS proteins) constrain G protein-coupled receptor (GPCR)-mediated and other responses throughout the body primarily, but not exclusively, through their GTPase activating (GAP) activity. Asthma is a highly prevalent condition characterized by airway hyper-responsiveness (AHR) to environmental stimuli resulting in part from amplified GPCR-mediated airway smooth muscle (ASM) contraction. Rgs2 or Rgs5 gene deletion in mice enhances AHR and ASM contraction whereas RGS4 knockout (KO) mice unexpectedly have decreased AHR due to increased production of the bronchodilator prostaglandin E2 (PGE2) by lung epithelial cells...
March 1, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38432211/monotropein-alleviates-ovalbumin-induced-asthma-in-mouse-model-by-inhibiting-akt-nf-%C3%AE%C2%BAb-pathway
#12
JOURNAL ARTICLE
Xin Guo, Wenjie Sun, Bingbing Zhang
INTRODUCTION: Clinical management of asthma remains as a prevalent challenge. Monotropein (MON) is a naturally occurring cyclic enol ether terpene glycoside with medical application potential. This study aims to evaluate the potential therapeutic effects of MON in the mouse model of chronic asthma. METHODS: An ovalbumin (OVA)-induced asthmatic mouse model was established to evaluate the therapeutic effect of MON at different doses (20, 40, and 80 mg/kg). The potential involvement of protein kinase B (AKT)/nuclear factor kappa B (NF-κB) pathway in the effect of MON was investigated by the administration of an AKT activator SC79...
March 1, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38422885/human-beta-defensin-3-knockdown-inhibits-the-proliferation-and-migration-of-airway-smooth-muscle-cells-through-regulating-the-pi3k-akt-signaling-pathway
#13
JOURNAL ARTICLE
Guiying Chen, Yuling Zheng, Nan Wu, Xia Yang, Shuqiang Qu
Asthma, a common pediatric pulmonary disease, significantly affects children's healthy development. This study aimed to investigate the functions of human β defensin-3 (HBD-3) in asthma progression. For this purpose, blood samples from asthmatic and healthy children were collected. Moreover, the airway smooth muscle cells (ASMCs) were treated with platelet-derived growth factor BB (PDGF-BB) to develop an in vitro asthma model, then evaluated cell viability and migration via CCK-8 and transwell assays...
February 28, 2024: Molecular Immunology
https://read.qxmd.com/read/38411938/notoginsenoside-r1-restrains-the-proliferation-and-migration-of-airway-smooth-muscle-cells-isolated-from-rats-with-chronic-obstructive-pulmonary-disease
#14
JOURNAL ARTICLE
Xiaoyong Li, Kai Chen, Xuefei Shi, Shunli Dong, Yi Chen, Bin Wang
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a common disorder that is characterized by systemic and lung inflammation. Notoginsenoside R1 (NGR1) displays anti-inflammatory properties in numerous diseases. We aimed to explore the function and mechanism of NGR1 in COPD. MATERIALS AND METHODS: COPD rats were established through cigarette smoke exposure, lipopolysaccharide injection, and cold stimulation. Rat airway smooth muscle cells (ASMCs) were separated and identified...
February 27, 2024: Inhalation Toxicology
https://read.qxmd.com/read/38409848/mast-cell-chymase-suppresses-functional-parameters-in-primary-human-airway-smooth-muscle-cells
#15
JOURNAL ARTICLE
Xinran O Zhao, Fabio Rabelo Melo, Christian P Sommerhoff, Aida Paivandy, Gunnar Pejler
No abstract text is available yet for this article.
February 26, 2024: Allergy
https://read.qxmd.com/read/38409842/down-regulation-of-insr-restores-th17-treg-immune-balance-and-alleviates-airway-hyperviscosity-in-asthmatic-mice-via-inactivation-of-stat3-pathway
#16
JOURNAL ARTICLE
Xuanlin Jin, Jin Wang
BACKGROUND: Allergic asthma (AA) is a prevalent chronic airway inflammation disease. In this study, this study aims to investigate the biological functions and potential regulatory mechanisms of the insulin receptor ( INSR ) in the progression of AA. METHODS: BALB/c mice (n = 48) were randomly divided into the following groups: control group, AA group, AA+Lentivirus (Lv)-vector short hairpin RNA (shRNA) group, AA+Lv-vector group, AA+Lv- INSR shRNA group, and AA+Lv- INSR group...
February 2024: Discovery Medicine
https://read.qxmd.com/read/38409837/sfrp5-partially-inhibits-the-proliferation-and-migration-of-airway-smooth-muscle-cells-in-children-with-asthma-by-regulating-the-wnt-%C3%AE-catenin-signaling-pathway
#17
JOURNAL ARTICLE
Yuyun Yuan, Honghua Zhu, Sihong Huang, Yantao Zhang, Yiyun Shen
BACKGROUND: Childhood asthma is a chronic inflammatory disease of the respiratory tract characterized by bronchial inflammation, airway hyperresponsiveness, airflow disorder, and obstruction. Secreted frizzled-related protein 5 (SFRP5) may be associated with respiratory inflammatory diseases. This study investigated the effect of SFRP5 on human airway smooth muscle cells (HASMCs) to provide new ideas for treating asthma. METHODS: A total of 30 children with asthma and 30 children who had a physical examination at the same time were selected and divided into asthma and healthy groups...
February 2024: Discovery Medicine
https://read.qxmd.com/read/38401465/morita-baylis-hillman-adduct-2-3-hydroxy-1-methyl-2-oxoindolin-3-il-acrylonitrile-cisacn-ameliorates-the-pulmonary-allergic-inflammation-in-caras-model-by-increasing-ifn-%C3%AE-il-4-ratio-towards-the-th1-immune-response
#18
JOURNAL ARTICLE
Larissa Adilis Maria Paiva Ferreira, Laércia Karla Diega Paiva Ferreira, Raquel Fragoso Pereira Cavalcanti, Francisco Allysson de Assis Ferreira Gadelha, Louise Mangueira de Lima, Adriano Francisco Alves, Cláudio Gabriel Lima Júnior, Marcia Regina Piuvezam
Combined allergic rhinitis and asthma syndrome (CARAS) is an airway-type 2 immune response with a profuse inflammatory process widely affecting the world population. Due to the compromise of quality of life and the lack of specific pharmacotherapy, the search for new molecules becomes relevant. This study aimed to evaluate the effectiveness of the Morita-Bailys-Hillman adduct (CISACN) treatment in the CARAS experimental model. Female BALB/c mice were ovalbumin (OVA) -sensitized and -challenged and treated with CISACN...
February 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38398039/unraveling-the-link-between-%C3%AE-nsulin-resistance-and-bronchial-asthma
#19
REVIEW
Konstantinos Bartziokas, Andriana I Papaioannou, Fotios Drakopanagiotakis, Evanthia Gouveri, Nikolaos Papanas, Paschalis Steiropoulos
Evidence from large epidemiological studies has shown that obesity may predispose to increased Th2 inflammation and increase the odds of developing asthma. On the other hand, there is growing evidence suggesting that metabolic dysregulation that occurs with obesity, and more specifically hyperglycemia and insulin resistance, may modify immune cell function and in some degree systemic inflammation. Insulin resistance seldom occurs on its own, and in most cases constitutes a clinical component of metabolic syndrome, along with central obesity and dyslipidemia...
February 16, 2024: Biomedicines
https://read.qxmd.com/read/38396994/adam33-s-role-in-asthma-pathogenesis-an-overview
#20
REVIEW
Jakub Sleziak, Antoni Gawor, Marta Błażejewska, Katarzyna Antosz, Krzysztof Gomułka
Asthma is a complex chronic respiratory disease characterized by airway hyperresponsiveness, inflammation, and obstruction. Many genes have been identified as associated with asthma but none with such substantial significance as the ADAM33 gene due to its role in airway remodeling and bronchial hyperresponsiveness. This review summarizes the current knowledge on the genetic and functional aspects of ADAM33 in asthma pathogenesis. We highlight its genetic variants associated with asthma susceptibility and severity, as well as the functional effects of ADAM33 on airway remodeling, smooth muscle cell proliferation, and its interplay with environmental factors...
February 15, 2024: International Journal of Molecular Sciences
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