Pei-Pei Cheng, Fan Yu, Shuai-Jun Chen, Xiao Feng, Zi-Heng Jia, Shi-He Hu, Xiao-Lin Cui, Ya-Ya Zhou, Qian Niu, Li-Mei Liang, Meng Wang, Lin-Jie Song, Xin-Liang He, Liang Xiong, Fei Xiang, Xiaorong Wang, Wan-Li Ma, Hong Ye
Fine particulate matter (PM2.5) has been linked to increased severity and incidence of airway diseases, especially chronic obstructive pulmonary disease (COPD) and asthma. Airway remodeling is an important event in both COPD and asthma, and airway smooth muscle cells (ASMCs) are key cells which directly involved in airway remodeling. However, it was unclear how PM2.5 affected ASMCs. This study investigates the effects of PM2.5 on airway smooth muscle and its mechanism. We first showed that inhaled particulate matter was distributed in the airway smooth muscle bundle, combined with increased airway smooth muscle bundle and collagen deposition in vivo...
March 6, 2024: Environmental Pollution