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https://www.readbyqxmd.com/read/28445530/computation-of-adherence-to-medication-and-visualization-of-medication-histories-in-r-with-adherer-towards-transparent-and-reproducible-use-of-electronic-healthcare-data
#1
Alexandra Lelia Dima, Dan Dediu
Adherence to medications is an important indicator of the quality of medication management and impacts on health outcomes and cost-effectiveness of healthcare delivery. Electronic healthcare data (EHD) are increasingly used to estimate adherence in research and clinical practice, yet standardization and transparency of data processing are still a concern. Comprehensive and flexible open-source algorithms can facilitate the development of high-quality, consistent, and reproducible evidence in this field. Some EHD-based clinical decision support systems (CDSS) include visualization of medication histories, but this is rarely integrated in adherence analyses and not easily accessible for data exploration or implementation in new clinical settings...
2017: PloS One
https://www.readbyqxmd.com/read/28428301/whole-genome-sequence-of-corynebacterium-pseudotuberculosis-pa04-isolated-from-the-lymph-node-of-a-sheep-in-the-amazon-brazil
#2
Wana L O Costa, Jorianne T C Alves, Larissa M Dias, Carlos Leonardo de Aragão Araújo, Eziquiel Morais, André G M Silva, Soraya S Andrade, Rommel T J Ramos, Artur Silva, Adriana R C Folador
This study reports the complete genome sequence of Corynebacterium pseudotuberculosis strain PA04, isolated from a sheep in the Amazon, Brazil. This bacterium is the etiological agent of caseous lymphadenitis. This genome contains 2,338,093 bp, 52.2% G+C content, and a total of 2,104 coding sequences (CDSs), 41 pseudogenes, 12 rRNAs, and 49 tRNAs.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28416295/depressive-symptoms-in-schizophrenia-and-dopamine-and-serotonin-gene-polymorphisms
#3
Vjekoslav Peitl, Mario Štefanović, Dalibor Karlović
Although depressive symptoms seem to be frequent in schizophrenia they have received significantly less attention than other symptom domains. As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. Other objectives of this study were to closely examine schizophrenia symptom domains by performing factor analysis of the two most used instruments in this setting (Positive and negative syndrome scale - PANSS and Calgary depression rating scale - CDSS) and to examine the influence of investigated gene polymorphisms on the schizophrenia symptom domains, focusing on depressive scores...
April 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28414583/improved-depressive-symptoms-in-adults-with-schizophrenia-during-a-smoking-cessation-attempt-with-varenicline-and-behavioral-therapy
#4
Corinne Cather, Susanne Hoeppner, Gladys Pachas, Sarah Pratt, Eric Achtyes, Kristina M Cieslak, A Eden Evins
OBJECTIVE: Smoking prevalence rates are elevated in individuals with schizophrenia spectrum disorders (SSD) compared with the general population, with attendant disproportionate smoking-related morbidity and mortality. Pharmacotherapies that improve abstinence rates in this population are underutilized, partly due to concerns about neuropsychiatric safety, particularly for those with comorbid depression or prior suicide attempt. Prospective assessment of the psychiatric safety profile of varenicline in those with SSD is needed...
April 17, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28401259/mechanism-of-salinomycin-overproduction-in-streptomyces-albus-as-revealed-by-comparative-functional-genomics
#5
Xiaojie Zhang, Chenyang Lu, Linquan Bai
The anticoccidial salinomycin is a polyketide produced by Streptomyces albus, and the high-yield strain BK 3-25 produces 18.0 g/L salinomycin under lab condition. In order to elucidate the overproduction mechanism, the genome of BK 3-25 was fully sequenced and compared with the wild-type DSM 41398. Strain BK 3-25 has a 75-kb large deletion, containing type-I polyketide gene cluster PKS-9, and 60 additional InDels and SNVs affecting 55 CDSs, including a 1-bp deletion in type-I PKS gene cluster PKS-6. Subsequently, individual or combined deletions of the 75-kb region and PKS-6 in the wild-type resulted in improved salinomycin yields from 2...
April 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28385856/updated-reference-genome-sequence-and-annotation-of-mycobacterium-bovis-af2122-97
#6
Kerri M Malone, Damien Farrell, Tod P Stuber, Olga T Schubert, Ruedi Aebersold, Suelee Robbe-Austerman, Stephen V Gordon
We report here an update to the reference genome sequence of the bovine tuberculosis bacillus Mycobacterium bovis AF2122/97, generated using an integrative multiomics approach. The update includes 42 new coding sequences (CDSs), 14 modified annotations, 26 single-nucleotide polymorphism (SNP) corrections, and disclosure that the RD900 locus, previously described as absent from the genome, is in fact present.
April 6, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28373881/clinical-decision-support-systems-for-comorbidity-architecture-algorithms-and-applications
#7
Aihua Fan, Di Lin, Yu Tang
In this paper, we present the design of a clinical decision support system (CDSS) for monitoring comorbid conditions. Specifically, we address the architecture of a CDSS by characterizing it from three layers and discuss the algorithms in each layer. Also we address the applications of CDSSs in a few real scenarios and analyze the accuracy of a CDSS in consideration of the potential conflicts when using multiple clinical practice guidelines concurrently. Finally, we compare the system performance in our design with that in the other design schemes...
2017: International Journal of Telemedicine and Applications
https://www.readbyqxmd.com/read/28361157/integration-of-hospital-information-and-clinical-decision-support-systems-to-enable-the-reuse-of-electronic-health-record-data
#8
Georgy Kopanitsa
BACKGROUND: The efficiency and acceptance of clinical decision support systems (CDSS) can increase if they reuse medical data captured during health care delivery. High heterogeneity of the existing legacy data formats has become the main barrier for the reuse of data. Thus, we need to apply data modeling mechanisms that provide standardization, transformation, accumulation and querying medical data to allow its reuse. OBJECTIVES: In this paper, we focus on the interoperability issues of the hospital information systems (HIS) and CDSS data integration...
March 31, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28355601/a-revised-fibrinogen-cutoff-value-in-the-chinese-disseminated-intravascular-coagulation-scoring-system-may-provide-a-better-prognostic-value-for-hematological-malignancies
#9
Qing Wei, Ting Niu, Mengyao Wang, Jinrong Yang, Pengpeng Liu, Yuyao Yi
To retrospectively validate the prognostic value of the latest Chinese disseminated intravascular coagulation (DIC) scoring system (CDSS) in hematological malignancies, 260 patients with confirmed hematological malignancies and suspected DIC in West China Hospital between 2011 and 2015 were included in this study. We evaluated via univariate and multivariate analyses the diagnostic biomarkers, and the cutoff levels used in the CDSS, except those for fibrinogen, were found to be valid. In subgroup analyses, the value of fibrinogen was found to be mainly unfit for the acute promyelocytic leukemia group...
March 30, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28336591/draft-genome-sequence-of-corynebacterium-pseudotuberculosis-strain-pa07-biovar-ovis-isolated-from-a-sheep-udder-in-amazonia
#10
Fabrício Almeida Araújo, Joana Montezano Marques, Vitória Almeida Gonçalves de Moura, Maria Paula Cruz Schneider, Soraya Silva Andrade, Alyne Cristina Sodré Lima, Luis Carlos Guimarães, Adriana Ribeiro Carneiro Folador, Artur Silva, Rommel T J Ramos
In this work, we present the draft genome sequence of Corynebacterium pseudotuberculosis strain PA07 biovar ovis, isolated from a caseous secretion from a sheep udder in Pará, Brazil. The genome contains 2,320,235 bp, 52.2% G+C content, 2,191 coding sequences (CDSs), five pseudogenes, 48 tRNAs, and three rRNAs.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28335474/coccolithoviruses-a-review-of-cross-kingdom-genomic-thievery-and-metabolic-thuggery
#11
Jozef I Nissimov, António Pagarete, Fangrui Ma, Sean Cody, David D Dunigan, Susan A Kimmance, Michael J Allen
Coccolithoviruses (Phycodnaviridae) infect and lyse the most ubiquitous and successful coccolithophorid in modern oceans, Emiliania huxleyi. So far, the genomes of 13 of these giant lytic viruses (i.e., Emiliania huxleyi viruses-EhVs) have been sequenced, assembled, and annotated. Here, we performed an in-depth comparison of their genomes to try and contextualize the ecological and evolutionary traits of these viruses. The genomes of these EhVs have from 444 to 548 coding sequences (CDSs). Presence/absence analysis of CDSs identified putative genes with particular ecological significance, namely sialidase, phosphate permease, and sphingolipid biosynthesis...
March 18, 2017: Viruses
https://www.readbyqxmd.com/read/28333302/outcomes-of-multisite-antimicrobial-stewardship-programme-implementation-with-a-shared-clinical-decision-support-system
#12
Stuart E Bond, Adriana J Chubaty, Suman Adhikari, Spiros Miyakis, Craig S Boutlis, Wilfred W Yeo, Marijka J Batterham, Cara Dickson, Brendan J McMullan, Mona Mostaghim, Samantha Li-Yan Hui, Kate R Clezy, Pamela Konecny
Background: Studies evaluating antimicrobial stewardship programmes (ASPs) supported by computerized clinical decision support systems (CDSSs) have predominantly been conducted in single site metropolitan hospitals. Objectives: To examine outcomes of multisite ASP implementation supported by a centrally deployed CDSS. Methods: An interrupted time series study was conducted across five hospitals in New South Wales, Australia, from 2010 to 2014...
March 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28319117/comparative-genomics-of-clavibacter-michiganensis-subspecies-pathogens-of-important-agricultural-crops
#13
James T Tambong
Subspecies of Clavibacter michiganensis are important phytobacterial pathogens causing devastating diseases in several agricultural crops. The genome organizations of these pathogens are poorly understood. Here, the complete genomes of 5 subspecies (C. michiganensis subsp. michiganensis, Cmi; C. michiganensis subsp. sepedonicus, Cms; C. michiganensis subsp. nebraskensis, Cmn; C. michiganensis subsp. insidiosus, Cmi and C. michiganensis subsp. capsici, Cmc) were analyzed. This study assessed the taxonomic position of the subspecies based on 16S rRNA and genome-based DNA homology and concludes that there is ample evidence to elevate some of the subspecies to species-level...
2017: PloS One
https://www.readbyqxmd.com/read/28315621/scales-for-assessment-of-depression-in-schizophrenia-factor-analysis-of-calgary-depression-rating-scale-and-hamilton-depression-rating-scale
#14
Sandeep Grover, Swapnajeet Sahoo, Devakshi Dua, Subho Chakrabarti, Ajit Avasthi
This study aimed to evaluate the factor structure of Calgary depression rating scale (CDSS) and Hamilton Depression Rating Scale (HDRS) among patients with schizophrenia in acute and remission phase of illness by using exploratory factor analysis. For this, 267 patients with schizophrenia were assessed on CDSS and HDRS. Exploratory factor analysis of CDSS yielded 2 factor models for the whole sample, patients in clinical remission and patients not in clinical remission phase of schizophrenia. Factor analysis of HDRS yielded 3 factor models; however, there was significant difference in the factor structure between those in clinical remission and those not in clinical remission phase of schizophrenia...
March 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28273629/insight-and-suicidality-in-psychosis-a-cross-sectional-study
#15
Carmen Massons, Javier-David Lopez-Morinigo, Esther Pousa, Ada Ruiz, Susana Ochoa, Judith Usall, Lourdes Nieto, Jesus Cobo, Anthony S David, Rina Dutta
AIMS: We aimed to test whether specific insight dimensions are associated with suicidality in patients with psychotic disorders. METHODS: 143 patients with schizophrenia spectrum disorders were recruited. Suicidality was assessed by item 8 of the Calgary Depression Scale for Schizophrenia (CDSS). Insight was measured by the Scale of Unawareness of Mental Disorder (SUMD) and the Markova and Berrios Insight Scale. Bivariate analyses and multivariable logistic regression models were conducted...
February 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28268836/advanced-analytics-for-outcome-prediction-in-intensive-care-units
#16
Ali Jalali, Dieter Bender, Mohamed Rehman, Vinay Nadkanri, C Nataraj
In this paper we present a new expert knowledge based clinical decision support system for prediction of intensive care units outcome based on the physiological measurements collected during the first 48 hours of the patient's admission to the ICU. The developed CDSS algorithm is composed of several stages. First, we categorize the collected data based on the physiological organ that they represent. We then extract clinically relevant features from each data category and then rank these features based on their mutual information with the outcome...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268133/a-systematic-review-of-clinical-decision-support-systems-for-antimicrobial-management-are-we-failing-to-investigate-these-interventions-appropriately
#17
REVIEW
Timothy M Rawson, Luke Sp Moore, Bernard Hernandez, Esmita Charani, Enrique Castro-Sanchez, Pau Herrero, Benedict Hayhoe, William Hope, Pantelis Georgiou, Alison H Holmes
OBJECTIVES: Clinical decision support systems (CDSS) for antimicrobial management can support clinicians to optimise antimicrobial therapy. We reviewed all original literature (qualitative and quantitative) to understand the current scope of CDSS for antimicrobial management and analyse existing methods used to evaluate and report such systems. METHOD: PRISMA guidelines were followed. Medline, EMBASE, HMIC Health and Management, and Global Health databases were searched from 1(st) January 1980 to 31(st) October 2015...
March 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28262587/diversity-of-the-photosynthetic-paulinella-species-with-the-description-of-paulinella-micropora-sp-nov-and-the-chromatophore-genome-sequence-for-strain-kr01
#18
Duckhyun Lhee, Eun Chan Yang, Jong Im Kim, Takuro Nakayama, Giuseppe Zuccarello, Robert A Andersen, Hwan Su Yoon
The thecate filose amoeba Paulinella chromatophora is a good model organism for understanding plastid organellogenesis because its chromatophore was newly derived from an alpha-cyanobacterium. Paulinella chromatophora was the only known photosynthetic Paulinella species until recent studies that suggested a species level of diversity. Here, we described a new photosynthetic species P. micropora sp. nov. based on morphological and molecular evidence from a newly established strain KR01. The chromatophore genome of P...
February 14, 2017: Protist
https://www.readbyqxmd.com/read/28254989/complete-genome-sequence-of-bradyrhizobium-diazoefficiens-usda-122-a-nitrogen-fixing-soybean-symbiont
#19
Masayuki Sugawara, Takahiro Tsukui, Takakazu Kaneko, Yoshiyuki Ohtsubo, Shusei Sato, Yuji Nagata, Masataka Tsuda, Hisayuki Mitsui, Kiwamu Minamisawa
We report the complete genome sequence of Bradyrhizobium diazoefficiens USDA 122, a nitrogen-fixing soybean symbiont. The genome consists of a 9.1 Mb circular chromosome, and 8,551 coding sequences (CDSs) were predicted on the genome. The sequence will provide insight into the evolution of rhizobial genome, and the symbiotic compatibility with host plants.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28241943/the-impact-of-health-information-technology-on-organ-transplant-care-a-systematic-review
#20
REVIEW
Zahra Niazkhani, Habibollah Pirnejad, Parviz Rashidi Khazaee
BACKGROUND: Health Information Technology (HIT) has a potential to promote transplant care. However, a systematic appraisal on how HIT application has so far affected transplant care is greatly missing from the literature. We systematically reviewed trials that evaluated HIT impact on process and patient outcomes as well as costs in organ transplant care. METHODS: A systematic search was conducted in OVID versions of MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane, and IEEE databases from January 1990 to December 2015...
April 2017: International Journal of Medical Informatics
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