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https://www.readbyqxmd.com/read/28523007/transcriptomic-identification-of-drought-related-genes-and-ssr-markers-in-sudan-grass-based-on-rna-seq
#1
Yongqun Zhu, Xia Wang, Linkai Huang, Chaowen Lin, Xinquan Zhang, Wenzhi Xu, Jianhua Peng, Zhou Li, Haidong Yan, Fuxiang Luo, Xie Wang, Li Yao, Dandan Peng
Sudan grass (Sorghum sudanense) is an annual warm-season gramineous forage grass that is widely used as pasture, hay, and silage. However, drought stress severely impacts its yield, and there is limited information about the mechanisms of drought tolerance in Sudan grass. In this study, we used next-generation sequencing to identify differentially expressed genes (DEGs) in the Sudan grass variety Wulate No.1, and we developed simple sequence repeat (SSR) markers associated with drought stress. From 852,543,826 raw reads, nearly 816,854,366 clean reads were identified and used for analysis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28521782/combining-alcohol-interventions-with-tobacco-addictions-treatment-in-primary-care-the-combat-study-a-pragmatic-cluster-randomized-trial
#2
Nadia Minian, Dolly Baliunas, Laurie Zawertailo, Aliya Noormohamed, Norman Giesbrecht, Christian S Hendershot, Bernard Le Foll, Jürgen Rehm, Andriy Samokhvalov, Peter L Selby
BACKGROUND: Tobacco and alcohol use present multiplicative risk for aerodigestive cancers. Reducing alcohol consumption improves smoking cessation outcomes and reduces cancer risk. Risky alcohol consumption and smoking are often treated separately despite concurrent treatment potentially leading to better outcomes for each. However, no rapidly scalable program exists for combined interventions in primary care clinics spread across wide geographic areas. This cluster randomized trial aims to report on the effects of a novel clinical decision support system (CDSS) on intervention rates by primary care practitioners addressing risky alcohol use in a smoking cessation program...
May 18, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28508778/supporting-molecular-tumor-boards-in-molecular-guided-decision-making-the-current-status-of-five-german-university-hospitals
#3
Marc Hinderer, Melanie Boerries, Florian Haller, Sebastian Wagner, Stefanie Sollfrank, Till Acker, Hans-Ulrich Prokosch, Jan Christoph
BACKGROUND: German university hospitals have started to establish molecular tumor boards in order to enable physicians to make molecular-guided decisions. OBJECTIVE: Our aim was to describe the organizational structure and procedures which are currently supporting the molecular tumor boards of five German university hospitals. METHODS: We conducted semi-structured interviews with experts of five university hospitals between December 2016 and February 2017...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28503978/comparison-of-depression-symptoms-between-primary-depression-and-secondary-to-schizophrenia-depression
#4
Twana Rahim, Roshe Rashid
OBJECTIVES: This study exclusively aimed to clinically assess which symptom pattern discriminates primary depression from depression-secondary to-schizophrenia. METHODS: A total of 98 patients with primary depression and 71 patients with secondary-to-schizophrenia depression were assessed for identifying the clinical phenomena of depression. Diagnosis of schizophrenia was confirmed by Mini International Neuropsychiatric Interview. Each participant was, however, assessed by Patient Health Questionnaire-9 as well as Calgary Depression Scale for Schizophrenia (CDSS) for possible concurrent depressive symptoms...
May 15, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28503490/the-distinct-transcriptional-response-of-the-midgut-of-amblyomma-sculptum-and-amblyomma-aureolatum-ticks-to-rickettsia-rickettsii-correlates-to-their-differences-in-susceptibility-to-infection
#5
Larissa A Martins, Maria F B de Melo Galletti, José M Ribeiro, André Fujita, Francisco B Costa, Marcelo B Labruna, Sirlei Daffre, Andréa C Fogaça
Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes Rocky Mountain Spotted Fever (RMSF). In Brazil, two species of ticks in the genus Amblyomma, A. sculptum and A. aureolatum, are incriminated as vectors of this bacterium. Importantly, these two species present remarkable differences in susceptibility to R. rickettsii infection, where A. aureolatum is more susceptible than A. sculptum. In the current study, A. aureolatum and A. sculptum ticks were fed on suitable hosts previously inoculated with R...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28499446/genome-sequence-of-shigella-flexneri-strain-sp1-a-diarrheal-isolate-that-encodes-an-extended-spectrum-%C3%AE-lactamase-esbl
#6
Ping Shen, Jianzhong Fan, Lihua Guo, Jiahua Li, Ang Li, Jing Zhang, Chaoqun Ying, Jinru Ji, Hao Xu, Beiwen Zheng, Yonghong Xiao
BACKGROUND: Shigellosis is the most common cause of gastrointestinal infections in developing countries. In China, the species most frequently responsible for shigellosis is Shigella flexneri. S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on biochemical and serological properties. Moreover, increasing numbers of ESBL-producing Shigella strains have been isolated from clinical samples. Despite this, only a few cases of ESBL-producing Shigella have been described in China...
May 12, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28493049/identification-and-differential-expression-of-biomineralization-genes-in-the-mantle-of-pearl-oyster-pinctada-fucata
#7
Haimei Li, Bo Zhang, Sigang Fan, Baosuo Liu, Jiaqi Su, Dahui Yu
A series of proteins are involved in shell formation of the pearl oyster Pinctada fucata, but the involved mechanisms and the relative expression levels of these proteins have not been elucidated. In this study, we sequenced and characterized the transcriptome of P. fucata mantle tissue. A total of 100,679 unique transcripts were assembled, 43687 Unigenes were annotated, and 48654 CDSs were determined. Of these, GO annotated 16353 Unigenes, COG defined 11585 unigenes into 25 categories, and KEGG sorted 25053 unigenes into 258 pathways...
May 10, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28488947/translation-control-learning-from-viruses-again
#8
Juana Díez, Jennifer Jungfleisch
Viruses are powerful tools to uncover cellular processes. Through viral studies we have recently identified a novel translational control mechanism that involves the DEAD-box helicase Dhh1/DDX6 and RNA folding within coding sequences (CDSs). All Dhh1-dependent mRNAs, viral and cellular ones, (i) contain long and highly structured CDSs, (ii) are directly bound by Dhh1 with a specific pattern, (iii) are activated at the translation initiation step and (iv) express proteins associated with the endoplasmic reticulum...
May 10, 2017: RNA Biology
https://www.readbyqxmd.com/read/28484048/novel-translation-initiation-regulation-mechanism-in-escherichia-coli-ptrb-mediated-by-a-5-terminal-aug
#9
Heather J Beck, Gary R Janssen
Alternative translation initiation mechanisms, distinct from the Shine-Dalgarno (SD) sequence-dependent mechanism, are more prevalent in bacteria than once anticipated. Translation of Escherichia coliptrB instead requires an AUG triplet at the 5'-terminus of its messenger RNA (mRNA). The 5'-terminal AUG (5'-uAUG) acts as a ribosomal recognition signal to attract ribosomes to the ptrB mRNA rather than functioning as an initiation codon to support translation of an upstream open reading frame. ptrB expression exhibits a stronger dependence on the 5'-uAUG than the predicted SD sequence; however, strengthening the predicted ptrB SD sequence relieves the necessity for the 5'-uAUG...
May 8, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28455596/clinical-decision-support-systems-in-child-and-adolescent-psychiatry-a-systematic-review
#10
REVIEW
Roman Koposov, Sturla Fossum, Thomas Frodl, Øystein Nytrø, Bennett Leventhal, Andre Sourander, Silvana Quaglini, Massimo Molteni, María de la Iglesia Vayá, Hans-Ulrich Prokosch, Nicola Barbarini, Michael Peter Milham, Francisco Xavier Castellanos, Norbert Skokauskas
Psychiatric disorders are amongst the most prevalent and impairing conditions in childhood and adolescence. Unfortunately, it is well known that general practitioners (GPs) and other frontline health providers (i.e., child protection workers, public health nurses, and pediatricians) are not adequately trained to address these ubiquitous problems (Braddick et al. Child and Adolescent mental health in Europe: infrastructures, policy and programmes, European Communities, 2009; Levav et al. Eur Child Adolesc Psychiatry 13:395-401, 2004)...
April 28, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28451686/data-requirements-for-the-correct-identification-of-medication-errors-and-adverse-drug-events-in-patients-presenting-at-an-emergency-department
#11
Bettina Plank-Kiegele, Thomas Bürkle, Fabian Müller, Andrius Patapovas, Anja Sonst, Barbara Pfistermeister, Harald Dormann, Renke Maas
BACKGROUND: Adverse drug events (ADE) involving or not involving medication errors (ME) are common, but frequently remain undetected as such. Presently, the majority of available clinical decision support systems (CDSS) relies mostly on coded medication data for the generation of drug alerts. It was the aim of our study to identify the key types of data required for the adequate detection and classification of adverse drug events (ADE) and medication errors (ME) in patients presenting at an emergency department (ED)...
April 28, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28450506/draft-genome-sequence-of-the-nylon-oligomer-degrading-bacterium-arthrobacter-sp-strain-ki72
#12
Ikki Takehara, Dai-Ichiro Kato, Masahiro Takeo, Seiji Negoro
We report here the 4.6-Mb genome sequence of a nylon oligomer-degrading bacterium, Arthrobacter sp. strain KI72. The draft genome sequence of strain KI72 consists of 4,568,574 bp, with a G+C content of 63.47%, 4,372 coding sequences (CDSs), 54 tRNAs, and six rRNAs.
April 27, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28449639/clovr-comparative-automated-cloud-enabled-comparative-microbial-genome-sequence-analysis-pipeline
#13
Sonia Agrawal, Cesar Arze, Ricky S Adkins, Jonathan Crabtree, David Riley, Mahesh Vangala, Kevin Galens, Claire M Fraser, Hervé Tettelin, Owen White, Samuel V Angiuoli, Anup Mahurkar, W Florian Fricke
BACKGROUND: The benefit of increasing genomic sequence data to the scientific community depends on easy-to-use, scalable bioinformatics support. CloVR-Comparative combines commonly used bioinformatics tools into an intuitive, automated, and cloud-enabled analysis pipeline for comparative microbial genomics. RESULTS: CloVR-Comparative runs on annotated complete or draft genome sequences that are uploaded by the user or selected via a taxonomic tree-based user interface and downloaded from NCBI...
April 27, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28445530/computation-of-adherence-to-medication-and-visualization-of-medication-histories-in-r-with-adherer-towards-transparent-and-reproducible-use-of-electronic-healthcare-data
#14
Alexandra Lelia Dima, Dan Dediu
Adherence to medications is an important indicator of the quality of medication management and impacts on health outcomes and cost-effectiveness of healthcare delivery. Electronic healthcare data (EHD) are increasingly used to estimate adherence in research and clinical practice, yet standardization and transparency of data processing are still a concern. Comprehensive and flexible open-source algorithms can facilitate the development of high-quality, consistent, and reproducible evidence in this field. Some EHD-based clinical decision support systems (CDSS) include visualization of medication histories, but this is rarely integrated in adherence analyses and not easily accessible for data exploration or implementation in new clinical settings...
2017: PloS One
https://www.readbyqxmd.com/read/28428301/whole-genome-sequence-of-corynebacterium-pseudotuberculosis-pa04-isolated-from-the-lymph-node-of-a-sheep-in-the-amazon-brazil
#15
Wana L O Costa, Jorianne T C Alves, Larissa M Dias, Carlos Leonardo de Aragão Araújo, Eziquiel Morais, André G M Silva, Soraya S Andrade, Rommel T J Ramos, Artur Silva, Adriana R C Folador
This study reports the complete genome sequence of Corynebacterium pseudotuberculosis strain PA04, isolated from a sheep in the Amazon, Brazil. This bacterium is the etiological agent of caseous lymphadenitis. This genome contains 2,338,093 bp, 52.2% G+C content, and a total of 2,104 coding sequences (CDSs), 41 pseudogenes, 12 rRNAs, and 49 tRNAs.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28416295/depressive-symptoms-in-schizophrenia-and-dopamine-and-serotonin-gene-polymorphisms
#16
Vjekoslav Peitl, Mario Štefanović, Dalibor Karlović
Although depressive symptoms seem to be frequent in schizophrenia they have received significantly less attention than other symptom domains. As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. Other objectives of this study were to closely examine schizophrenia symptom domains by performing factor analysis of the two most used instruments in this setting (Positive and negative syndrome scale - PANSS and Calgary depression rating scale - CDSS) and to examine the influence of investigated gene polymorphisms on the schizophrenia symptom domains, focusing on depressive scores...
April 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28414583/improved-depressive-symptoms-in-adults-with-schizophrenia-during-a-smoking-cessation-attempt-with-varenicline-and-behavioral-therapy
#17
Corinne Cather, Susanne Hoeppner, Gladys Pachas, Sarah Pratt, Eric Achtyes, Kristina M Cieslak, A Eden Evins
OBJECTIVE: Smoking prevalence rates are elevated in individuals with schizophrenia spectrum disorders (SSD) compared with the general population, with attendant disproportionate smoking-related morbidity and mortality. Pharmacotherapies that improve abstinence rates in this population are underutilized, partly due to concerns about neuropsychiatric safety, particularly for those with comorbid depression or prior suicide attempt. Prospective assessment of the psychiatric safety profile of varenicline in those with SSD is needed...
April 17, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28401259/mechanism-of-salinomycin-overproduction-in-streptomyces-albus-as-revealed-by-comparative-functional-genomics
#18
Xiaojie Zhang, Chenyang Lu, Linquan Bai
The anticoccidial salinomycin is a polyketide produced by Streptomyces albus, and the high-yield strain BK 3-25 produces 18.0 g/L salinomycin under lab condition. In order to elucidate the overproduction mechanism, the genome of BK 3-25 was fully sequenced and compared with the wild-type DSM 41398. Strain BK 3-25 has a 75-kb large deletion, containing type-I polyketide gene cluster PKS-9, and 60 additional InDels and SNVs affecting 55 CDSs, including a 1-bp deletion in type-I PKS gene cluster PKS-6. Subsequently, individual or combined deletions of the 75-kb region and PKS-6 in the wild-type resulted in improved salinomycin yields from 2...
April 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28385856/updated-reference-genome-sequence-and-annotation-of-mycobacterium-bovis-af2122-97
#19
Kerri M Malone, Damien Farrell, Tod P Stuber, Olga T Schubert, Ruedi Aebersold, Suelee Robbe-Austerman, Stephen V Gordon
We report here an update to the reference genome sequence of the bovine tuberculosis bacillus Mycobacterium bovis AF2122/97, generated using an integrative multiomics approach. The update includes 42 new coding sequences (CDSs), 14 modified annotations, 26 single-nucleotide polymorphism (SNP) corrections, and disclosure that the RD900 locus, previously described as absent from the genome, is in fact present.
April 6, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28373881/clinical-decision-support-systems-for-comorbidity-architecture-algorithms-and-applications
#20
Aihua Fan, Di Lin, Yu Tang
In this paper, we present the design of a clinical decision support system (CDSS) for monitoring comorbid conditions. Specifically, we address the architecture of a CDSS by characterizing it from three layers and discuss the algorithms in each layer. Also we address the applications of CDSSs in a few real scenarios and analyze the accuracy of a CDSS in consideration of the potential conflicts when using multiple clinical practice guidelines concurrently. Finally, we compare the system performance in our design with that in the other design schemes...
2017: International Journal of Telemedicine and Applications
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