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https://www.readbyqxmd.com/read/28933675/using-the-concept-of-hubots-to-understand-the-work-entailed-in-using-digital-technologies-in-healthcare
#1
Catherine Pope, Joanne Turnbull
Purpose The purpose of this paper is to explore the human work entailed in the deployment of digital health care technology. It draws on imagined configurations of computers and machines in fiction and social science to think about the relationship between technology and people, and why this makes implementation of digital technology so difficult. The term hubots is employed as a metaphorical device to examine how machines and humans come together to do the work of healthcare. Design/methodology/approach This paper uses the fictional depiction of hubots to reconceptualise the deployment of a particular technology - a computer decision support system (CDSS) used in emergency and urgent care services...
August 21, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28917193/high-c-reactive-protein-levels-are-associated-with-depressive-symptoms-in-schizophrenia
#2
M Faugere, J-A Micoulaud-Franchi, C Faget-Agius, C Lançon, M Cermolacce, R Richieri
BACKGROUND: Depressive symptoms are frequently associated with schizophrenia symptoms. C - Reactive protein (CRP), a marker of chronic inflammation, had been found elevated in patients with schizophrenia and in patients with depressive symptoms. However, the association between CRP level and depressive symptoms has been poorly investigated in patients with schizophrenia. The only study conducted found an association between high CRP levels and antidepressant consumption, but not with depressive symptoms investigated with the Calgary Depression Rating Scale for Schizophrenia (CDSS)...
September 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28916298/childhood-trauma-depression-and-sleep-quality-and-their-association-with-psychotic-symptoms-and-suicidality-in-schizophrenia
#3
Esin Evren Kilicaslan, Asli Tugba Esen, Meltem Izci Kasal, Erdal Ozelci, Murat Boysan, Mustafa Gulec
This study involved the examination of the relationship between childhood trauma and both psychotic symptoms and suicidality in patients with schizophrenia after controlling for the possible confounding factors, such as clinical features, depression, and sleep quality. The Childhood Trauma Questionnaire-Short Form, Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Pittsburgh Sleep Quality Index (PSQI), and the suicidality subscale of Mini-International Neuropsychiatric Interview (MINI) were administered to 199 patients with schizophrenia...
September 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28915822/what-hinders-the-uptake-of-computerized-decision-support-systems-in-hospitals-a-qualitative-study-and-framework-for-implementation
#4
Elisa G Liberati, Francesca Ruggiero, Laura Galuppo, Mara Gorli, Marien González-Lorenzo, Marco Maraldi, Pietro Ruggieri, Hernan Polo Friz, Giuseppe Scaratti, Koren H Kwag, Roberto Vespignani, Lorenzo Moja
BACKGROUND: Advanced Computerized Decision Support Systems (CDSSs) assist clinicians in their decision-making process, generating recommendations based on up-to-date scientific evidence. Although this technology has the potential to improve the quality of patient care, its mere provision does not guarantee uptake: even where CDSSs are available, clinicians often fail to adopt their recommendations. This study examines the barriers and facilitators to the uptake of an evidence-based CDSS as perceived by diverse health professionals in hospitals at different stages of CDSS adoption...
September 15, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28912306/complete-nucleotide-sequence-of-klebsiella-pneumoniae-bacteriophage-vb_kpnm_kpv477
#5
Ekaterina V Komisarova, Angelina A Kislichkina, Valentina M Krasilnikova, Alexander G Bogun, Nadezhda K Fursova, Nikolay V Volozhantsev
The double-stranded DNA (dsDNA) bacteriophage vB_KpnM_KpV477, with a broad spectrum of lytic activity against Klebsiella pneumoniae, including strains of capsular serotypes K1, K2, and K57, was isolated from a clinical sample. The phage genome comprises 168,272 bp, with a G+C content of 39.3%, and it contains 275 putative coding sequences (CDSs) and 17 tRNAs.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28905658/decision-support-for-diabetes-in-scotland-implementation-and-evaluation-of-a-clinical-decision-support-system
#6
Nicholas Conway, Karen A Adamson, Scott G Cunningham, Alistair Emslie Smith, Peter Nyberg, Blair H Smith, Ann Wales, Deborah J Wake
BACKGROUND: Automated clinical decision support systems (CDSS) are associated with improvements in health care delivery to those with long-term conditions, including diabetes. A CDSS was introduced to two Scottish regions (combined diabetes population ~30 000) via a national diabetes electronic health record. This study aims to describe users' reactions to the CDSS and to quantify impact on clinical processes and outcomes over two improvement cycles: December 2013 to February 2014 and August 2014 to November 2014...
September 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28892310/genetic-diversity-of-marine-anaerobic-ammonium-oxidizing-bacteria-as-revealed-by-genomic-and-proteomic-analyses-of-candidatus-scalindua-japonica
#7
Mamoru Oshiki, Keisuke Mizuto, Zenichiro Kimura, Tomonori Kindaichi, Hisashi Satoh, Satoshi Okabe
Anaerobic ammonium-oxidizing (anammox) bacteria affiliated with the genus 'Candidatus Scalindua' are responsible for significant nitrogen loss in oceans, and thus their ecophysiology is of great interest. Here, we enriched a marine anammox bacterium, 'Ca. S. japonica' from a Hiroshima bay sediment in Japan, and comparative genomic and proteomic analyses of 'Ca. S. japonica' were conducted. Sequence of the 4.81-Mb genome containing 4,019 coding regions of genes (CDSs) composed of 47 contigs was determined. In the proteome, 1,762 out of 4,019 CDSs in the 'Ca...
September 11, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28883185/factors-influencing-the-implementation-and-distribution-of-clinical-decision-support-systems-cdss
#8
Benjamin R Kux, Raphael W Majeed, Janko Ahlbrandt, Rainer Röhrig
Clinical Decision Support Systems (CDSS) can have positive effects on quality of care measures, yet have not gained widespread traction in healthcare. This study sought to determine and evaluate barriers and facilitators to CDSS implementation and distribution. Based on 768 systems identified in a literature review we conducted semi-structured telephone interviews with 54 system developers in 16 countries. Qualitative analysis led to the identification of 66 key factors influencing implementation. Central issues evolved around CDSS properties, quality and integration, as well as usability, user related factors, internal marketing, resource issues and collaborations with emphasis partly on topics differing from existing research...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28860263/genome-sequence-of-rhizobium-esperanzae-type-strain-cnpso-668-isolated-from-phaseolus-vulgaris-nodules-in-mexico
#9
Luisa Caroline Ferraz Helene, Renan Augusto Ribeiro, Mariangela Hungria
Rhizobium esperanzae CNPSo 668(T) is a nitrogen-fixing symbiont of Phaseolus vulgaris isolated from Mexican soils. Its genome is estimated at 6,294,057 bp, with 6,219 coding sequences (CDSs) showing higher similarity (92.9%) with Rhizobium etli Three copies of the regulatory nodD, in addition to other nodulation genes, should define its host specificity.
August 31, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28859829/multi-model-based-interactive-authoring-environment-for-creating-shareable-medical-knowledge
#10
Taqdir Ali, Maqbool Hussain, Wajahat Ali Khan, Muhammad Afzal, Jamil Hussain, Rahman Ali, Waseem Hassan, Arif Jamshed, Byeong Ho Kang, Sungyoung Lee
OBJECTIVE: Technologically integrated healthcare environments can be realized if physicians are encouraged to use smart systems for the creation and sharing of knowledge used in clinical decision support systems (CDSS). While CDSSs are heading toward smart environments, they lack support for abstraction of technology-oriented knowledge from physicians. Therefore, abstraction in the form of a user-friendly and flexible authoring environment is required in order for physicians to create shareable and interoperable knowledge for CDSS workflows...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28845167/validation-of-the-korean-version-of-the-clinical-assessment-interview-for-negative-symptoms
#11
Seon-Kyeong Jang, Seon-Cheol Park, Kee-Hong Choi, Jung-Seo Yi, Joong-Kyu Park, Jung Suk Lee, Seung-Hwan Lee
OBJECTIVE: Clinical Assessment Interview for Negative Symptoms (CAINS) has recently been developed to improve measurement of negative symptoms in schizophrenia. We performed a multi-center study to validate the Korean version of the CAINS (CAINS-K) and explore potential cultural variation. METHODS: One hundred eighty schizophrenia patients diverse in demographic and illness profile were recruited from four centers in Korea. Along with the CAINS-K, the Scale for the Assessment of Negative Symptoms (SANS), Brief Psychiatric Rating Scale (BPRS), Calgary Depression Scale for Schizophrenia (CDSS), a self-report measure of behavioral inhibition and activation (BIS/BAS) and neurocognitive tasks were administered to verify external validities...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28839341/long-term-safety-and-tolerability-of-valbenazine-nbi-98854-in-subjects-with-tardive-dyskinesia-and-a-diagnosis-of-schizophrenia-or-mood-disorder
#12
Richard C Josiassen, John M Kane, Grace S Liang, Joshua Burke, Christopher F O'Brien
BACKGROUND: The short-term safety profile of once-daily valbenazine (NBI-98854) has been evaluated in several double-blind, placebo-controlled (DBPC) trials in adults with tardive dyskinesia (TD) who had a diagnosis of schizophrenia/schizoaffective (SCHZ) disorder or mood disorder. Studies with longer treatment duration (up to 48 weeks) were conducted to evaluate the long-term safety of this novel drug in subjects with TD. METHODS: The pooled long-term exposure (LTE) population included valbenazine-treated subjects from 3 studies: KINECT (NCT01688037: 6-week DBPC, 6-week open-label); KINECT 3 (NCT02274558: 6-week DBPC, 42-week blinded extension, 4-week drug-free follow-up); KINECT 4 (NCT02405091: 48-week open-label, 4-week drug-free follow-up)...
August 1, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28831134/evaluation-of-the-new-chinese-disseminated-intravascular-coagulation-scoring-system-in-critically-ill-patients-a-multicenter-prospective-study
#13
Yingying Wu, Lili Luo, Ting Niu, Yue Han, Ying Feng, Qiulan Ding, Ruibin Huang, Xiaohui Zhang, Jianming Feng, Ming Hou, Jun Peng, Yan Li, Yuhong Zhou, Lei Su, Linhua Yang, Zeping Zhou, Feng Xue, Jian Gu, Tienan Zhu, Xiaomin Wang, Jun Deng, Heng Mei, Yu Hu
Disseminated intravascular coagulation (DIC) is a common life-threatening complication in critically ill patients. The diagnostic scoring systems of DIC enable a more prompt and accurate diagnosis of DIC, such as the International Society on Thrombosis and Haemostasis (ISTH), the Japanese Association for Acute Medicine (JAAM) and the Japanese Ministry of Health and Welfare (JMHW). This study prospectively evaluated the newly proposed Chinese DIC Scoring System (CDSS), which was conducted at 18 centers in China during a one-year period...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28829318/event-based-impulsive-control-of-continuous-time-dynamic-systems-and-its-application-to-synchronization-of-memristive-neural-networks
#14
Wei Zhu, Dandan Wang, Lu Liu, Gang Feng
This paper investigates exponential stabilization of continuous-time dynamic systems (CDSs) via event-based impulsive control (EIC) approaches, where the impulsive instants are determined by certain state-dependent triggering condition. The global exponential stability criteria via EIC are derived for nonlinear and linear CDSs, respectively. It is also shown that there is no Zeno-behavior for the concerned closed loop control system. In addition, the developed event-based impulsive scheme is applied to the synchronization problem of master and slave memristive neural networks...
August 18, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28798739/comprehensive-analysis-of-codon-usage-bias-in-seven-epichlo%C3%A3-species-and-their-peramine-coding-genes
#15
Hui Song, Jing Liu, Qiuyan Song, Qingping Zhang, Pei Tian, Zhibiao Nan
Codon usage bias plays an important role in shaping genomes and genes in unicellular species and multicellular species. Here, we first analyzed codon usage bias in seven Epichloë species and their peramine-coding genes. Our results showed that both natural selection and mutation pressure played a role in forming codon usage bias in seven Epichloë species. All seven Epichloë species contained a peramine-coding gene cluster. Interestingly, codon usage bias of peramine-coding genes were not affected by natural selection or mutation pressure...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28795172/change-point-detection-method-for-clinical-decision-support-system-rule-monitoring
#16
Siqi Liu, Adam Wright, Milos Hauskrecht
A clinical decision support system (CDSS) and its components can malfunction due to various reasons. Monitoring the system and detecting its malfunctions can help one to avoid any potential mistakes and associated costs. In this paper, we investigate the problem of detecting changes in the CDSS operation, in particular its monitoring and alerting subsystem, by monitoring its rule firing counts. The detection should be performed online, that is whenever a new datum arrives, we want to have a score indicating how likely there is a change in the system...
June 2017: Artif Intell Med (2017)
https://www.readbyqxmd.com/read/28789633/variations-in-5s-rdnas-in-diploid-and-tetraploid-offspring-of-red-crucian-carp-%C3%A3-common-carp
#17
Lihai Ye, Chun Zhang, Xiaojun Tang, Yiyi Chen, Shaojun Liu
BACKGROUND: The allotetraploid hybrid fish (4nAT) that was created in a previous study through an intergeneric cross between red crucian carp (Carassius auratus red var., ♀) and common carp (Cyprinus carpio L., ♂) provided an excellent platform to investigate the effect of hybridization and polyploidization on the evolution of 5S rDNA. The 5S rDNAs of paternal common carp were made up of a coding sequence (CDS) and a non-transcribed spacer (NTS) unit, and while the 5S rDNAs of maternal red crucian carp contained a CDS and a NTS unit, they also contained a variable number of interposed regions (IPRs)...
August 8, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28774991/draft-genome-sequences-of-bacillus-subtilis-strain-dku_nt_01-isolated-from-traditional-korean-food-containing-soybean-chung-gook-jang
#18
Man-Seok Bang, Hee-Won Jeong, Yea-Jin Lee, Ha-Yeong Oh, Su Ji Lee, Moon-Soo Shim, Jang-In Shin, Chung-Hun Oh
Here, we report the whole-genome sequence of Bacillus subtilis strain DKU_NT_01 isolated from traditional Korean food containing soybean (chung-gook-jang). The de novo genome of Bacillus subtilis strain DKU_NT_01 has one contig and G+C content of 55.4%, is 4,954,264 bp in length, and contains 5,011 coding sequences (CDSs).
August 3, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28770029/complete-genome-sequence-of-the-sand-sediment-actinobacterium-nocardioides-dokdonensis-fr1436-t
#19
Min-Jung Kwak, Soon-Kyeong Kwon, Jihyun F Kim
Nocardioides dokdonensis, belonging to the class Actinobacteria, was first isolated from sand sediment of a beach in Dokdo, Korea, in 2005. In this study, we determined the genome sequence of FR1436, the type strain of N. dokdonensis, and analyzed its gene contents. The genome sequence is the second complete one in the genus Nocardioides after that of Nocardioides sp. JS614. It is composed of a 4,376,707-bp chromosome with a G + C content of 72.26%. From the genome sequence, 4,104 CDSs, three rRNA operons, 51 tRNAs, and one tmRNA were predicted, and 71...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28760143/decision-support-during-electronic-prescription-to-stem-antibiotic-overuse-for-acute-respiratory-infections-a-long-term-quasi-experimental-study
#20
Jeneen Gifford, Elisabeth Vaeth, Katherine Richards, Tariq Siddiqui, Christine Gill, Lucy Wilson, Sylvain DeLisle
BACKGROUND: Interventions to support decision-making can reduce inappropriate antibiotic use for acute respiratory infections (ARI), but they may not be sustainable. The objective of the study is to evaluate the long-term effectiveness of a clinical decision-support system (CDSS) interposed at the time of electronic (e-) prescriptions for selected antibiotics. METHODS: This is a retrospective, observational intervention study, conducted within a large, statewide Veterans Affairs health system...
July 31, 2017: BMC Infectious Diseases
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