keyword
MENU ▼
Read by QxMD icon Read
search

tumor stem cell

keyword
https://www.readbyqxmd.com/read/29475141/quercetin-enhances-chemotherapeutic-effect-of-doxorubicin-against-human-breast-cancer-cells-while-reducing-toxic-side-effects-of-it
#1
Shizheng Li, Song Yuan, Qian Zhao, Bo Wang, Xiuyan Wang, Kun Li
Doxorubicin (Dox) is an efficient drug for breast cancer chemotherapy, however, its toxic side effects on non-tumor tissues, especially on myocardial cells, sometimes limit its clinical application. Therefore, it is necessary to develop a new drug, which can be combined with Dox to potentiate the anti-tumor effect of Dox at a lower concentration and attenuate the toxic side effects of it. Quercetin (Que) has anti-tumor activity in addition to its protective effects on various cells. By preparing human non-tumoral MCF-10A mammary cells, human breast cancer MCF-7 and MDA-MB-231 cells and human myocardial AC16 cells, here, we wanted to evaluate whether Que might represent such an agent and investigate its possible mechanisms of potentiating the anti-tumor effect of Dox at a lower concentration...
February 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29474981/physiological-functions-of-fbw7-in-cancer-and-metabolism
#2
REVIEW
Kouhei Shimizu, Naoe Taira Nihira, Hiroyuki Inuzuka, Wenyi Wei
FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCFFBW7 plays key roles in regulating cell cycle progression, differentiation, and stem cell maintenance largely through targeting a broad range of oncogenic substrates for proteasome-dependent degradation. The identification of an increasing number of FBW7 substrates for ubiquitination, and intensive in vitro and in vivo studies have revealed a network of signaling components controlled by FBW7 that contributes to metabolic regulation as well as its tumor suppressor role...
February 20, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29473334/treatment-related-mortality-in-newly-diagnosed-pediatric-cancer-a-population-based-analysis
#3
Paul Gibson, Jason D Pole, Tanya Lazor, Donna Johnston, Carol Portwine, Mariana Silva, Sarah Alexander, Lillian Sung
Using a previously developed reliable and valid treatment-related mortality (TRM) definition, our objective was to describe the proportion of children newly diagnosed with cancer experiencing TRM and to identify risk factors for TRM in a population-based cohort. We included children with cancer <19 years diagnosed and treated in Ontario who were diagnosed between 2003 and 2012. Children with cancer were identified using data in a provincial registry. Cumulative incidence of TRM was calculated where progressive disease death was considered a competing event...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29472691/a-reappraisal-of-ctla-4-checkpoint-blockade-in-cancer-immunotherapy
#4
Xuexiang Du, Fei Tang, Mingyue Liu, Juanjuan Su, Yan Zhang, Wei Wu, Martin Devenport, Christopher A Lazarski, Peng Zhang, Xu Wang, Peiying Ye, Changyu Wang, Eugene Hwang, Tinghui Zhu, Ting Xu, Pan Zheng, Yang Liu
It is assumed that anti-CTLA-4 antibodies cause tumor rejection by blocking negative signaling from B7-CTLA-4 interactions. Surprisingly, at concentrations considerably higher than plasma levels achieved by clinically effective dosing, the anti-CTLA-4 antibody Ipilimumab blocks neither B7 trans-endocytosis by CTLA-4 nor CTLA-4 binding to immobilized or cell-associated B7. Consequently, Ipilimumab does not increase B7 on dendritic cells (DCs) from either CTLA4 gene humanized (Ctla4h/h ) or human CD34+ stem cell-reconstituted NSG™ mice...
February 22, 2018: Cell Research
https://www.readbyqxmd.com/read/29471794/lgr5-overexpression-confers-poor-relapse-free-survival-in-breast-cancer-patients
#5
Ming-Feng Hou, Po-Ming Chen, Pei-Yi Chu
BACKGROUND: Cancer stem cells (CSCs) are believed to promote the malignant transformation of breast cancer via multiple signaling pathways, including the Wnt/β-catenin pathway. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has been identified as a CSC-associated Wnt-regulated target gene, but its clinical significance in the context of breast cancer remains elusive. Therefore, the purpose of this study was to investigate the clinical significance of the LGR5-β-catenin axis in breast cancer...
February 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29471169/pegylated-dendritic-polyglycerol-conjugate-targeting-ncam-expressing-neuroblastoma-limitations-and-challenges
#6
Laura Isabel Vossen, Ela Markovsky, Anat Eldar-Boock, Harald Rune Tschiche, Stefanie Wedepohl, Evgeny Pisarevsky, Ronit Satchi-Fainaro, Marcelo Calderón
Neural cell adhesion molecule (NCAM) is found to be a stem-cell marker in several tumor types and its overexpression is known to correlate with increased metastatic capacity. To combine extravasation- and ligand-dependent targeting to NCAM overexpressing-cells in the tumor microenvironment, we developed a PEGylated NCAM-targeted dendritic polyglycerol (PG) conjugate. Here, we describe the synthesis, physico-chemical characterization and biological evaluation of a PG conjugate bearing the mitotic inhibitor paclitaxel (PTX) and an NCAM-targeting peptide (NTP)...
February 19, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29470831/expression-and-function-of-immune-ligand-receptor-pairs-in-nk-cells-and-cancer-stem-cells-therapeutic-implications
#7
REVIEW
Ioannis A Voutsadakis
BACKGROUND: The interplay between the immune system and cancer cells has come to the forefront of cancer therapeutics, with novel immune blockade inhibitors being approved for the treatment of an increasing list of cancers. However, the majority of cancer patients still display or develop resistance to these promising drugs. It is possible that cancer stem cells (CSCs) are contributing to this therapeutic resistance. Although CSCs usually represent a small percentage of the total number of cancer cells, they are endowed with the ability of self-renewal and to produce differentiated progeny...
February 22, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29470822/the-concept-of-the-ccn-protein-family-revisited-a-centralized-coordination-network
#8
REVIEW
Bernard Perbal
The wide array of biological properties attributed to the CCN family of proteins (Perbal in Lancet 363(9402):62-64, 2004) led me to reconsider the possible relationship and roles that these proteins may play as a team, instead of acting on their own as individual regulators in various signaling pathways. The dynamic model which I present in this review stems from the contribution of the biological properties that we established for CCN3, one of the three founding members of the CCN family, which was identified by our group as the first CCN protein showing growth inhibitory properties (1992), expressed mainly in quiescent cells (1996), and showing anti-tumor activities in several cellular models both ex vivo and in vivo...
February 22, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29469747/multiple-eccrine-spiradenomas-in-a-zosteriform-pattern
#9
Monica Rosales Santillan, Kathrene ATajnert, Michael G Swaby, Michael R Migden, Sirunya Silapunt
Eccrine spiradenoma (ES) typically presents as a solitary tender lesion. Multiple ES is a rare variant of ES and can present in a segmental, linear, blaschkoid, or zosteriform pattern. The etiology of multiple ES is unknown, but several theories have been suggested including a multipotent stem cell origin. We report the case of a 30-year-old woman with multiple painful ES in a zosteriform pattern on the mid-back and abdomen. Skin biopsy of a representative lesion demonstrated a circumscribed tumor nodule encapsulated by a fibrous capsule with diffuse dense basophilic proliferation located in the dermis...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469746/allergic-contact-dermatitis-to-methylisothiazolinone-in-hair-care-products-report-of-a-case
#10
Rachel Gilmore, Girija Shan, Rajani Katta
Eccrine spiradenoma (ES) typically presents as a solitary tender lesion. Multiple ES is a rare variant of ES and can present in a segmental, linear, blaschkoid, or zosteriform pattern. The etiology of multiple ES is unknown, but several theories have been suggested including a multipotent stem cell origin. We report the case of a 30-year-old woman with multiple painful ES in a zosteriform pattern on the mid-back and abdomen. Skin biopsy of a representative lesion demonstrated a circumscribed tumor nodule encapsulated by a fibrous capsule with diffuse dense basophilic proliferation located in the dermis...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469069/retrospective-analysis-of-patients-with-relapsed-or-refractory-testicular-nonseminous-germ-cell-tumors-treated-with-autologous-stem-cell-transplantation
#11
F Yilmaz, N Soyer, R Uslu, A P Erdogan, B Karaca, G Saydam, F Sahin, F Vural
BACKGROUND AND AIM: About 20-25% of the testicular germ cell tumors (TGCT) are relapsed or refractory after first line therapy and optimal treatment for this group is poorly defined. We aimed to analyze the efficacy and safety of autologous stem cell transplantation (ASCT) in this patient group.Material and. METHODS: 19 patients with 28 ASCT were retrospectively analyzed. All the patients were treated with BEP (Bleomycin, etoposide, cisplatin) as first line therapy and TIP(paclitexalifosfamide, cisplatin) was given as salvage chemotherapy...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29468872/quest-for-efficacious-next-generation-taxoid-anticancer-agents-and-their-tumor-targeted-delivery
#12
Iwao Ojima, Xin Wang, Yunrong Jing, Changwei Wang
Paclitaxel and docetaxel are among the most widely used chemotherapeutic drugs against various types of cancer. However, these drugs cause undesirable side effects as well as drug resistance. Therefore, it is essential to develop next-generation taxoid anticancer agents with better pharmacological properties and improved activity especially against drug-resistant and metastatic cancers. The SAR studies by the authors have led to the development of numerous highly potent novel second- and third-generation taxoids with systematic modifications at the C-2, C-10, and C-3' positions...
February 22, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29468856/chemoresistance-in-ovarian-cancer-exploiting-cancer-stem-cell-metabolism
#13
REVIEW
Shan Shan Li, Jing Ma, Alice S T Wong
Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent recurrence in patients with advanced diseases remains a therapeutic challenge. Thus, understanding the biology of chemoresistance is of great importance to overcome this challenge and will conceivably benefit the survival of ovarian cancer patients. Although mechanisms underlying the development of chemoresistance are still ambiguous, accumulating evidence has supported an integral role of cancer stem cells (CSCs) in recurrence following chemotherapy...
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29468726/immunohistochemical-expression-of-cd44-in-oral-squamous-cell-carcinoma-in-relation-to-histomorphologic-parameters-and-clinicopathological-factors
#14
Melanie Boxberg, Carolin Götz, Selgai Haidari, Christiane Dorfner, Moritz Jesinghaus, Enken Drecoll, Marko Boskov, Klaus Dietrich Wolff, Wilko Weichert, Bernhard Haller, Andreas Kolk
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is characterized by its variable clinical course. In addition to the routinely used TNM/UICC systems, patient-specific prognostic/predictive biomarkers are needed. Promising biomarkers include the determination of the cancer stem cell (CSC) compartment, which can be identified by CD44 expression (amongst others). MATERIALS AND METHODS: A well-characterized cohort of 108 therapy-naïve OSCC with complete long-term follow-up and matched lymph node metastases were evaluated for CD44 expression by immunohistochemistry...
February 22, 2018: Histopathology
https://www.readbyqxmd.com/read/29468482/epirubicin-induces-apoptosis-in-osteoblasts-through-death-receptor-and-mitochondrial-pathways
#15
Tzu-Ching Huang, Pu-Rong Chiu, Wen-Tsan Chang, Bau-Shan Hsieh, Yu-Ci Huang, Hsiao-Ling Cheng, Li-Wen Huang, Yu-Chen Hu, Kee-Lung Chang
Epirubicin is an anthracycline and is widely used in tumor treatment, but has toxic and undesirable side effects on wide range of cells and hematopoietic stem cells (HSC). Osteoblasts play important roles in bone development and in supporting HSC differentiation and maturation. It remains unknown whether epirubicin-induced bone loss and hematological toxicity are associated with its effect on osteoblasts. In primary osteoblast cell cultures, epirubicin inhibited cell growth and decreased mineralization. Moreover, epirubicin arrested osteoblasts in the G2/M phase, and this arrest was followed by apoptosis in which both the extrinsic (death receptor-mediated) and intrinsic (mitochondrial-mediated) apoptotic pathways were evoked...
February 21, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29468444/the-expression-of-the-msc-marker-cd73-and-of-nf2-merlin-are-correlated-in-meningiomas
#16
Elmar Kirches, Tabea Steffen, Natalie Waldt, Eva Hebert, Doreen Pachow, Annette Wilisch-Neumann, Gerburg Keilhoff, Thomas Schneider, Werner E K Braunsdorf, Jan-Peter Warnke, Christian Mawrin
Mesenchymal stem cells (MSC) have been found in various cancers and were discussed to influence tumor biology. Cells fulfilling the complete MSC criteria, including surface marker expression (CD73, CD90, CD105) and tri-lineage differentiation, have been isolated solely from a low percentage of high-grade meningiomas. In contrast, pure co-expression of the surface-markers was relatively frequent, raising the question for an additional role of these membrane proteins in meningiomas. Therefore, here we analyzed the expression of CD73, CD90 and CD105 in a series of meningiomas of all grades...
February 21, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29467963/new-extracellular-factors-in-glioblastoma-multiforme-development-neurotensin-growth-differentiation-factor-15-sphingosine-1-phosphate-and-cytomegalovirus-infection
#17
REVIEW
Jan Korbecki, Izabela Gutowska, Ireneusz Kojder, Dariusz Jeżewski, Marta Goschorska, Agnieszka Łukomska, Anna Lubkowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Recent years have seen considerable progress in understanding the biochemistry of cancer. For example, more significance is now assigned to the tumor microenvironment, especially with regard to intercellular signaling in the tumor niche which depends on many factors secreted by tumor cells. In addition, great progress has been made in understanding the influence of factors such as neurotensin, growth differentiation factor-15 (GDF-15), sphingosine-1-phosphate (S1P), and infection with cytomegalovirus (CMV) on the 'hallmarks of cancer' in glioblastoma multiforme...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467947/metformin-inhibits-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-like-process-and-stem-like-properties-in-gbm-via-akt-mtor-zeb1-pathway
#18
Yang Song, Yong Chen, Yunqian Li, Xiaoyan Lyu, Jiayue Cui, Ye Cheng, Liyan Zhao, Gang Zhao
Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. In spite of advances in diagnosis and therapy, the prognosis is still relatively poor. The invasive property of GBM is the major cause of death in patients. Epithelial-to-mesenchymal transition-like process (EMT-like process) is considered to play an important role in the invasive property. Metformin has been reported as a regulator of EMT-like process. In this study, we confirmed that metformin inhibited TGF-β1-induced EMT-like process and EMT-associated migration and invasion in LN18 and U87 GBM cells...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467936/dynamic-changes-in-cd44v-positive-cells-after-preoperative-anti-her2-therapy-and-its-correlation-with-pathologic-complete-response-in-her2-positive-breast-cancer
#19
Teruo Yamauchi, Jose Rodrigo Espinosa Fernandez, Chiyo K Imamura, Hideko Yamauchi, Hiromitsu Jinno, Maiko Takahashi, Yuko Kitagawa, Seigo Nakamura, Bora Lim, Savitri Krishnamurthy, James M Reuben, Diane Liu, Debasish Tripathy, Helen Chen, Naoko Takebe, Hideyuki Saya, Naoto T Ueno
Chemotherapy has been reported to increase the proportion of cancer stem cells (CSCs) and to promote epithelial-mesenchymal transition (EMT) phenotype changes. Anti-HER2 therapy may provide a strategy for eliminating CSC and EMT, which contribute to therapeutic resistance. No study has determined the changes in the quantity or characteristics of CSCs or circulating tumor cells (CTCs) with EMT phenotype during preoperative anti-HER2 therapy, and whether these changes correlate to response to dual anti-HER2 therapy...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467896/17%C3%AE-estradiol-regulates-the-malignancy-of-cancer-stem-like-cells-derived-from-the-mcf7-cell-line-partially-through-sox2
#20
Lian Guo, Feng Li, Mengyuan Wang, Yue Xu, Bangqiong Wang, Dongchuan Ran, Xianxiang Zhang
As a major common malignant tumor in women, the malignant behavior of breast cancer, which includes tumorigenesis and metastasis, is associated with estrogen, particularly 17β-estradiol (E2). With accumulating evidence demonstrating that cancer stem-like cells (CSCs) serve a function in the malignant behavior of breast cancer, including metastasis, recurrence and chemoresistance, the effects of E2 on the physiological processes of CSCs have been attracting more attention. In the present study, in order to investigate the effects of E2 on CSCs, CSCs from the MCF7 breast cancer cell line were isolated and treated with 1, 10 and 50 nM E2...
March 2018: Oncology Letters
keyword
keyword
13775
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"