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https://www.readbyqxmd.com/read/28399723/germline-heterozygous-variants-in-genes-associated-with-familial-hemophagocytic-lymphohistiocytosis-as-a-cause-of-increased-bleeding
#1
Marcus Fager Ferrari, Eva Leinoe, Maria Rossing, Eva Norström, Karin Strandberg, Tobias Steen Sejersen, Klaus Qvortrup, Eva Zetterberg
Familial hemophagocytic lymphohistiocytosis (FHL) is caused by biallelic variants in genes regulating granule secretion in cytotoxic lymphocytes. In FHL3-5, the affected genes UNC13D, STX11 and STXBP2 have further been shown to regulate the secretion of platelet granules, giving rise to compromised platelet function. Therefore, we aimed to investigate platelet degranulation in patients heterozygous for variants in UNC13D, STX11 and STXBP2. During the work-up of patients referred to the Coagulation Unit, Skåne University Hospital, Malmö, Sweden and the Department of Hematology, Rigshospitalet, Copenhagen, Denmark due to bleeding tendencies, 12 patients harboring heterozygous variants in UNC13D, STX11 or STXBP2 were identified using targeted whole exome sequencing...
April 11, 2017: Platelets
https://www.readbyqxmd.com/read/28326239/nanostructured-carbon-materials-decorated-with-organophosphorus-moieties-synthesis-and-application
#2
Giacomo Biagiotti, Vittoria Langè, Cristina Ligi, Stefano Caporali, Maurizio Muniz-Miranda, Anna Flis, K Michał Pietrusiewicz, Giacomo Ghini, Alberto Brandi, Stefano Cicchi
A new synthetic approach for the production of carbon nanomaterials (CNM) decorated with organophosphorus moieties is presented. Three different triphenylphosphine oxide (TPPO) derivatives were used to decorate oxidized multiwalled carbon nanotubes (ox-MWCNTs) and graphene platelets (GPs). The TPPOs chosen bear functional groups able to react with the CNMs by Tour reaction (an amino group), nitrene cycloaddition (an azido group) or CuAAC reaction (one terminal C-C triple bond). All the adducts were characterized by FTIR, Raman spectroscopy, TEM, XPS, elemental analysis and ICP-AES...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28301205/intratendon-delivery-of-leukocyte-poor-platelet-rich-plasma-improves-healing-compared-with-leukocyte-rich-platelet-rich-plasma-in-a-rabbit-achilles-tendinopathy-model
#3
Ruijian Yan, Yanjia Gu, Jisheng Ran, Yejun Hu, Zefeng Zheng, Mengfeng Zeng, Boon Chin Heng, Xiao Chen, Zi Yin, Weishan Chen, Weiliang Shen, Hongwei Ouyang
BACKGROUND: Chronic tendinopathy is a commonly occurring clinical problem that affects both athletes and inactive middle-aged patients. Although some studies have shown that different platelet-rich plasma (PRP) preparations could exert various therapeutic effects in vitro, the role of leukocytes in PRP has not yet been defined under tendinopathy conditions in vivo. PURPOSE: This study compared the effects of the intratendon delivery of leukocyte-poor PRP (Lp-PRP) versus leukocyte-rich PRP (Lr-PRP) in a rabbit chronic tendinopathy model in vivo...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28281715/metal-oxide-decorated-layered-silicate-magadiite-for-enhanced-properties-insight-from-zno-and-cuo-decoration
#4
Qiushi Wang, Yifu Zhang, Jiqi Zheng, Yu Wang, Tao Hu, Changgong Meng
Surface modification of a layered silicate magadiite (mag) was accomplished using cetyltrimethyl ammonium bromide (CTAB), copper oxide (CuO) and zinc oxide (ZnO). All the ions were intercalated using an ion-exchange reaction, and CuO and ZnO are prepared by a precipitation method. A precursor of CTAB modified mag enables good dispersion of the metal oxide on the surface of the lamellas. Characterization techniques (XRD, XRF, TGA, FTIR and XPS spectroscopy) confirmed that CuO and ZnO are homogeneously immobilized onto the silicate sheets of mag...
March 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28218402/characterization-of-the-%C3%AE-and-p-phase-precipitates-in-the-cmsx-4-single-crystal-superalloy
#5
B Dubiel, P Indyka, T Moskalewicz, A Kruk, M Zubko, I Kalemba-Rec, K Berent
A combination of scanning electron microscopy (SEM), transmission electron microscopy (TEM) and scanning-transmission electron microscopy (STEM) using high-angle annular-dark-field (HAADF) imaging, focussed ion beam- scanning electron microscopy (FIB-SEM) tomography, selected area electron diffraction with beam precession (PED), as well as spatially resolved energy-dispersive X-ray spectroscopy (EDS) and electron energy loss spectroscopy (EELS), was used to investigate topologically close-packed (TCP) phases, occurring in the CMSX-4 superalloy subjected to high temperature annealing and creep deformation...
February 20, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28169116/utilization-and-effectiveness-of-desmopressin-acetate-after-cardiac-surgery-supplemented-with-point-of-care-hemostatic-testing-a-propensity-score-matched-analysis
#6
David Orlov, Stuart A McCluskey, Jeannie Callum, Vivek Rao, Jacobo Moreno, Keyvan Karkouti
OBJECTIVES: To explore the utilization pattern and hemostatic effectiveness of desmopressin acetate (DDAVP) supplemented with point-of-care (POC) hemostatic testing in contemporary cardiac surgery. DESIGN: Retrospective, observational study. SETTING: Single quaternary care university hospital. PARTICIPANTS: The study comprised 2,468 consecutive patients undergoing cardiac surgery-1,237 before and 1,231 after the introduction of POC testing...
November 17, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28103989/-experimental-research-on-the-effects-of-different-activators-on-the-formation-of-platelet-rich-gel-and-the-release-of-bioactive-substances-in-human-platelet-rich-plasma
#7
Y Yang, W Zhang, B Cheng
Objective: To explore the effects of calcium gluconate and thrombin on the formation of platelet-rich gel (PRG) and the release of bioactive substances in human platelet-rich plasma (PRP) and the clinical significance. Methods: Six healthy blood donors who met the inclusion criteria were recruited in our unit from May to August in 2016. Platelet samples of each donor were collected for preparation of PRP. (1) PRP in the volume of 10 mL was collected from each donor and divided into thrombin activation group (TA, added with 0...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28091639/gold-nanoparticles-stabilized-by-cationic-carbosilane-dendrons-synthesis-and-biological-properties
#8
Cornelia E Peña-González, Elzbieta Pedziwiatr-Werbicka, Dzmitry Shcharbin, Carlos Guerrero-Beltrán, Viktar Abashkin, Svetlana Loznikova, José L Jiménez, M Ángeles Muñoz-Fernández, Maria Bryszewska, Rafael Gómez, Javier Sánchez-Nieves, F Javier de la Mata
Gold nanoparticles (AuNPs) and polycationic macromolecules are used as gene carriers. Their behaviour is dependent on several factors, such as the size and type of the framework, charge, etc. We have combined both types of systems and prepared AuNPs covered with cationic carbosilane dendrons with the aim to evaluate their biocompatibility. Water soluble dendronized cationic AuNPs were prepared following a straightforward procedure from dendrons, a gold precursor and a reducing agent in water and were characterized by (1)H NMR, transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), ultraviolet spectroscopy (UV), and zeta potential (ZP)...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27936777/peptizing-mechanism-at-the-molecular-level-of-laponite-nanoclay-gels
#9
Philip Kensbock, Dan Eugen Demco, Smriti Singh, Khosrow Rahimi, Radu Fechete, Andreas Walther, Annette Monika Schmidt, Martin Möller
In the presence of additives such as etidronic acid (1-hydroxyethane-1,1-diphosphonic acid, HEDP), a process of peptizing of Laponite clay gels takes place. The peptizing process at the molecular level was directly revealed by (31)P and (1)H high-resolution magic-angle sample spinning (HRMAS) NMR spectroscopy. Two NMR spectral components were detected and assigned to free etidronic acid and bound to the Laponite disk edges. Furthermore, with increase of temperature the ratio of bound-to-free etidronic acid increases...
December 21, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27926787/comparison-of-the-effects-of-a-balanced-crystalloid-based-and-a-saline-based-tetrastarch-solution-on-canine-whole-blood-coagulation-and-platelet-function
#10
RANDOMIZED CONTROLLED TRIAL
Annina Reuteler, Shannon Axiak-Flammer, Judith Howard, Katja-Nicole Adamik
OBJECTIVE: To evaluate the effects of a 6% hydroxyethyl starch (130/0.42) solution in either a buffered, electrolyte-balanced (HES-BAL), or a saline (HES-SAL) carrier solution on canine platelet function and whole blood coagulation. DESIGN: Prospective, randomized study. SETTING: University teaching hospital. ANIMALS: Thirty-seven client-owned dogs undergoing general anesthesia for arthroscopy or imaging studies. INTERVENTIONS: Dogs received a 15 mL/kg intravenous bolus of HES-SAL (n = 13), HES-BAL (n = 14), or a modified Ringer's solution (n = 10) over 30-40 minutes...
January 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27924343/synthesis-and-formulation-of-functional-bionanomaterials-with-superoxide-dismutase-activity
#11
Marko Pavlovic, Paul Rouster, Istvan Szilagyi
Layered double hydroxide (LDH) nanoparticles were prepared and used as solid support for superoxide dismutase (SOD) enzymes. Structural features were studied by XRD, spectroscopic methods (IR, UV-Vis and fluorescence) and TEM, while colloidal stability of the obtained materials was investigated by electrophoresis and light scattering in aqueous dispersions. The SOD quantitatively adsorbed on the LDH by electrostatic and hydrophobic interactions and kept its structural integrity upon immobilization. The composite material showed moderate resistance against salt-induced aggregation in dispersions, therefore, heparin polyelectrolyte was used to improve the colloidal stability of the system...
January 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/27911985/hemorrhagic-hemostatic-and-thromboelastometric-disorders-in-35-dogs-with-a-clinical-diagnosis-of-leptospirosis-a-prospective-study
#12
A Barthélemy, M Magnin, C Pouzot-Nevoret, J-M Bonnet-Garin, M Hugonnard, I Goy-Thollot
BACKGROUND: Leptospirosis in dogs is occasionally associated with a hemorrhagic syndrome, the pathophysiology of which is not fully understood. HYPOTHESIS/OBJECTIVES: To characterize hematologic, hemostatic, and thromboelastometric abnormalities in dogs with leptospirosis and to study their association with hemorrhagic diatheses and outcomes. ANIMALS: Thirty-five client-owned dogs. METHODS: A prospective observational single cohort study was conducted...
January 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27861436/the-association-between-cyanosis-and-thromboelastometry-rotem-in-children-with-congenital-heart-defects-a-retrospective-cohort-study
#13
Marie-Laure Laskine-Holland, Walter H A Kahr, Lynn Crawford-Lean, Tilman Humpl, Osami Honjo, Celeste Foreman, Mehr Jain, James D O'Leary
BACKGROUND: Children with congenital heart defects (CHD) have quantitative and qualitative differences in coagulation compared with healthy children. Secondary to polycythemia and increased deformability of red blood cells, cyanosis may be an important confounding factor for altered whole-blood coagulation in this population with potential implications for interpreting intraoperative thromboelastometry (TEM) for children with CHD undergoing major surgery. The primary aim of the study was to evaluate the association between cyanosis in children with CHD and measures of whole-blood coagulation determined using TEM (ROTEM [Tem International, GmbH, Munich, Germany])...
January 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27788125/high-performance-bio-based-hyperbranched-polyurethane-carbon-dot-silver-nanocomposite-a-rapid-self-expandable-stent
#14
Rituparna Duarah, Yogendra P Singh, Prerak Gupta, Biman B Mandal, Niranjan Karak
Development of a bio-based smart implantable material with multifaceted attributes of high performance, potent biocompatibility and inherent antibacterial property, particularly against drug resistant bacteria, is a challenging task in biomedical domain. Addressing these aspects at the bio-nano interface, we report the in situ fabrication of starch modified hyperbranched polyurethane (HPU) nanocomposites by incorporating different weight percentages of carbon dot-silver nanohybrid during polymerization process...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27777113/subsets-of-telocytes-myocardial-telocytes
#15
M C Rusu, S Hostiuc, A D Vrapciu, L Mogoantă, V S Mănoiu, F Grigoriu
Telocytes (TCs) are morphologically defined as small-sized cells with long, thin, moniliform processes called telopodes (Tps). Numerous papers imply that TCs are a distinctive cell type, and that transmission electron microscopy (TEM) is the gold standard tool for their identification. We aimed to reproduce previous studies on myocardial TCs to check their validity. For this purpose we performed an immunohistochemical study on human cardiac samples from six autopsied donor cadavers, using antibodies against CD10, CD31, CD34, CD146, Ki67, alpha-smooth muscle actin (α-SMA), Platelet-Derived Growth Factor Receptor-alpha (PDGFRα) and laminin...
January 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27708458/raft-dispersion-alternating-copolymerization-of-styrene-with-n-phenylmaleimide-morphology-control-and-application-as-an-aqueous-foam-stabilizer
#16
Pengcheng Yang, Oleksandr O Mykhaylyk, Elizabeth R Jones, Steven P Armes
We report a new nonaqueous polymerization-induced self-assembly (PISA) formulation based on the reversible addition-fragmentation chain transfer (RAFT) dispersion alternating copolymerization of styrene with N-phenylmaleimide using a nonionic poly(N,N-dimethylacrylamide) stabilizer in a 50/50 w/w ethanol/methyl ethyl ketone (MEK) mixture. The MEK cosolvent is significantly less toxic than the 1,4-dioxane cosolvent reported previously [Yang P.; Macromolecules2013, 46, 8545-8556]. The core-forming alternating copolymer block has a relatively high glass transition temperature (Tg), which leads to vesicular morphologies being observed during PISA, as well as the more typical sphere and worm phases...
September 27, 2016: Macromolecules
https://www.readbyqxmd.com/read/27543347/nano-hydroxyapatite-%C3%AE-cd-chitosan-nanocomposite-for-potential-applications-in-bone-tissue-engineering
#17
Mohammad Shakir, Reshma Jolly, Mohd Shoeb Khan, Ahmar Rauf, Shadab Kazmi
Herein, we report the synthesis of a novel tri-component nanocomposite system incorporating β-cyclodextrin (β-CD) with nano-hydroxyapatite (n-HA) and chitosan (CS), (n-HA/β-CD/CS) at three different temperatures via co-precipitation method. The chemical interactions and surface morphology have been evaluated by TEM, SEM and AFM techniques revealing the agglomerated nanoparticles in CS/n-HA-HA binary system whereas the ternary systems produced needle shaped nanoparticles dispersed homogeneously at low temperature with more porous and rougher surface...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27524091/starch-nanocrystals-based-hydrogel-construction-characterizations-and-transdermal-application
#18
Haja Bava Bakrudeen, C Sudarvizhi, B S R Reddy
Bio-based nanocomposites were prepared using starch nanocrystals obtained by acid hydrolysis of native starches using different acid sources. In recent times, focuses on starch nanocrystals (SNCs) have been increasing in number of research works dedicated to the development of bio-nanocomposites by blending with different biopolymeric matrices. The work mainly deals with the preparation of starch nanocrystals using different native starches by acid hydrolysis using hydrochloric acid and trifluroacetic acid...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27514638/structural-and-morphological-peculiarities-of-hybrid-au-nanodiamond-engineered-nanostructures
#19
Roberto Matassa, Silvia Orlanducci, Giacomo Reina, Maria Cristina Cassani, Daniele Passeri, Maria Letizia Terranova, Marco Rossi
Nanostructured Au nano-platelets have been synthesized from an Au(III) complex by growth process triggered by nanodiamond (ND). An electroless synthetic route has been used to obtain 2D Au/ND architectures, where individual nanodiamond particles are intimately embedded into face-centered cubic Au platelets. The combined use of high resolution transmission electron microscopy (HR-TEM) and selected area electron diffraction (SAED), was able to reveal the unusual organization of these hybrid nanoparticles, ascertaining the existence of preferential crystallographic orientations for both nanocrystalline species and highlighting their mutual locations...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27423322/time-dependent-apoptotic-rates-in-the-evolving-coronary-thrombus-mass-of-myocardial-infarction-patients
#20
Carlijn G Maagdenberg, Onno J de Boer, Xiaofei Li, Claire Mackaay, Hans W Niessen, Robbert J de Winter, Allard C Van der Wal
AIM: To study the rate of apoptotic cell death in the process of thrombus evolution after plaque rupture in myocardial infarction. METHODS: Paraffin embedded thrombosuction aspirates of 63 patients were stained with haematoxylin & eosin (H&E) to assess histologically the age of the thrombi: fresh (intact blood cells; <1day old), lytic (necrosis; 1-5days old) or organized (ingrowth of cells; >5days old). Presence of plaque constituents (atheroma including foam cells, cholesterol crystals calcifications and fibrous cap tissue) was also recorded...
September 2016: Thrombosis Research
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