Zoltán Szittner, Arthur E H Bentlage, A Robin Temming, David E Schmidt, Remco Visser, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J E van Esch, Myrthe E Sonneveld, Erik L de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, C Ellen van der Schoot, Gestur Vidarsson
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only a fraction of pregnancies, most commonly with anti-HPA-1a antibodies. We found that in particular, the core fucosylation in the IgG-Fc tail is highly variable in anti-HPA-1a IgG, which strongly influences the binding to leukocyte IgG-Fc receptors IIIa/b (FcγRIIIa/b). Currently, gold-standard IgG-glycoanalytics rely on complicated methods (e...
2023: Frontiers in Immunology