keyword
https://read.qxmd.com/read/38510813/performance-evaluation-of-dextran-coated-cafe-12-o-19-mnfe-2-o-4-exchange-spring-composites-for-the-self-heating-properties-at-radio-frequency-field
#1
JOURNAL ARTICLE
Ishtiaque Syed, Sharmin Akter Lima, Nandita Deb, M Al-Mamun, Sheikh Manjura Hoque
The CaFe12 O19 /MnFe2 O4 composites with the hard (CaFe12 O19 ) and soft (MnFe2 O4 ) magnetic phases, were prepared by chemical co-precipitation method. The prepared composites were calcined at three different temperatures to form different phases. The structural, morphological, and magnetic properties of composite were analyzed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), room temperature vibrational sample magnetometer (VSM), and transmission electron microscopy (TEM). The presence of the hard and soft phases has been confirmed without any secondary phase from XRD analysis, indicating the formation of composite...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38505171/targeted-delivery-of-mesenchymal-stem-cell-derived-bioinspired-exosome-mimetic-nanovesicles-with-platelet-membrane-fusion-for-atherosclerotic-treatment
#2
JOURNAL ARTICLE
Yu Jiang, Miao Yu, Zhi-Feng Song, Zhi-Yao Wei, Ji Huang, Hai-Yan Qian
PURPOSE: Accumulating evidence indicates that mesenchymal stem cells (MSCs)-derived exosomes hold significant potential for the treatment of atherosclerosis. However, large-scale production and organ-specific targeting of exosomes are still challenges for further clinical applications. This study aims to explore the targeted efficiency and therapeutic potential of biomimetic platelet membrane-coated exosome-mimetic nanovesicles (P-ENVs) in atherosclerosis. METHODS: To produce exosome-mimetic nanovesicles (ENVs), MSCs were successively extruded through polycarbonate porous membranes...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38433265/heterozygous-thbs2-pathogenic-variant-causes-ehlers-danlos-syndrome-with-prominent-vascular-features-in-humans-and-mice
#3
JOURNAL ARTICLE
Noam Hadar, Omri Porgador, Idan Cohen, Hilla Levi, Vadim Dolgin, Yuval Yogev, Sufa Sued-Hendrickson, Ilan Shelef, Elena Didkovsky, Marina Eskin-Schwartz, Ohad S Birk
Ehlers-Danlos syndromes (EDS) are a group of connective tissue disorders caused by mutations in collagen and collagen-interacting genes. We delineate a novel form of EDS with vascular features through clinical and histopathological phenotyping and genetic studies of a three-generation pedigree, displaying an apparently autosomal dominant phenotype of joint hypermobility and frequent joint dislocations, atrophic scarring, prolonged bleeding time and age-related aortic dilatation and rupture. Coagulation tests as well as platelet counts and function were normal...
March 4, 2024: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/38430017/effects-of-exosomes-derived-from-platelet-rich-plasma-on-osteogenic-differentiation-of-dental-pulp-stem-cells
#4
JOURNAL ARTICLE
Chuzi Mo, Zhongjun Liu, Yunhe Lin, Nu Er Bi Ya A Bu Du Xi Ku, Siwei Li, Qiao Ruan, Chengxia Liu, Shuaimei Xu, Jun Wen
Platelet-rich plasma (PRP) can cause osteogenic differentiation of dental pulp stem cells (DPSCs). However, the effect of exosomes derived from PRP (PRP-Exos) on osteogenic differentiation of DPSCs remains unclear. Herein, we evaluated the impact of PRP-Exos on osteogenic differentiation of DPSCs. PRP-Exos were isolated and identified by transmission electron microscopy (TEM) and western blotting (WB). Immunofluorescence staining was performed to evaluate endocytosis of PRP-Exos by DPSCs. Alkaline phosphatase staining, alizarin red staining, western blot and qRT-PCR were carried out to evaluate the DPSCs osteogenic differentiation...
February 29, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38423418/instant-mucus-dressing-of-peo-reinforced-by-chitosan-nanofiber-scaffold-for-open-wound-healing
#5
JOURNAL ARTICLE
Lei Fang, Yanling Hu, Zhihao Lin, Yanfei Ren, Xiuming Liu, Jixian Gong
Dressings seamlessly attached to the open wound bed are necessary for fully unleashing the dressing healing ability, as leaving the voids beneath the dressing poses infection hazards. The present study prepared an instant mucus dressing (IMD) of polyethylene oxide (PEO) reinforced by chitosan (CS) nanofiber scaffold, which formed by immersing PEO/CS nanofiber mat in water. The PEO/CS nanofiber mat were fabricated by the solution blow spinning (SBS) method using PEO and CS mixed solutions. Attenuated total reflection Fourier transform infrared spectroscopy (FTIR-ATR), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and differential scan calorimetry (DSC) analyses indicate that PEO macromolecules formed the most of nanofiber shell due to their lower surface tension while CS macromolecules stayed mainly inside the fiber as the core...
February 27, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38409035/inhibition-of-growth-of-hepatocellular-carcinoma-by-co-delivery-of-anti-pd-1-antibody-and-sorafenib-using-biomimetic-nano-platelets
#6
JOURNAL ARTICLE
Xuanbo Da, Bangping Cao, Jiantao Mo, Yukai Xiang, Hai Hu, Chen Qiu, Cheng Zhang, Beining Lv, Honglei Zhang, Chuanqi He, Yulong Yang
BACKGROUND: Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments. MATERIALS AND METHODS: Targeted drugs (Sorafenib, Sora) nanometers (hollow mesoporous silicon, HMSN) were designed, and then coated with platelet membranes to form aPD-1-PLTM-HMSNs@Sora to enhance the precision of drug delivery systems to the tumor microenvironment, so that more effective immunotherapy was achieved...
February 26, 2024: BMC Cancer
https://read.qxmd.com/read/38351883/evaluating-the-biological-antidiabetic-potential%C3%A2-of-tem-ftir-xrd-and-uv-spectra-observed-berberis-lyceum-conjugated-silver-nanoparticles
#7
JOURNAL ARTICLE
Tafail Akbar Mughal, Shaukat Ali, Shumaila Mumtaz, Muhammad Summer, Muhammad Zubair Saleem, Ali Hassan, Muhammad Usman Hameed
Diabetes is a life-threatening disease that affects different parts of the body including the liver, kidney, and pancreas. The core root of diabetes is mainly linked to oxidative stress produced by reactive oxygen species (ROS). Berberis lyceum Royle (BLR) is the source of natural products. It comprises numerous bioactive compounds having antioxidant activities. In the current investigation, silver nanoparticles from BLR root extract were synthesized, characterized, and assessed for antidiabetic potential...
February 14, 2024: Microscopy Research and Technique
https://read.qxmd.com/read/38276431/deposition-of-nial-al-3-ni-2-crb-2-coatings-from-ni-al-and-crb-2-powders-using-mechanical-synthesis-in-planetary-ball-mill
#8
JOURNAL ARTICLE
Maciej Szlezynger, Daniel Toboła, Jerzy Morgiel
Interest in composite thick coatings with an intermetallic matrix stimulates the development of new deposition techniques like the co-milling of pre-alloyed NiAl powder with platelet-shaped substrates. Obtained coatings were up to several micrometers thick as cold-welding of intermetallic particles was effective only at the start of this process, while later, chipping prevailed over added material. The present experiment covered the co-milling in the planetary ball mill of Ni and Al elemental powders (1:1 molar ratio) with AISI 304 steel platelets for 32 h at 300 rpm...
January 19, 2024: Materials
https://read.qxmd.com/read/38268594/characterization-and-treatment-effects-on-mutaka-kaolin-for-additive-in-coatings-mineral-composition-thermal-and-structural-modifications
#9
JOURNAL ARTICLE
Andrew Kasumba Buyondo, Hillary Kasedde, John Baptist Kirabira, Ocident Bongomin
Previous studies in Uganda have primarily explored kaolin's applications in composites, pottery, bricks, and insulation, neglecting its potential for coatings and paints, which is crucial for industrialization and saving foreign exchange. This study investigates the transformation of kaolin through various treatments and analyzes their impacts on its physical and chemical properties for potential use in coating applications. Thermal analysis, X-ray Fluorescence Spectroscopy (XRF), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), and transmission electron microscopy (TEM) techniques were employed to assess these alterations...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38147267/design-and-evaluation-of-ginkgolides-gastric-floating-controlled-release-tablets-based-on-solid-supersaturated-self-nanoemulsifying
#10
JOURNAL ARTICLE
Kai Zheng, Jing Zhao, Qiuli Wang, Yuyang Zhao, Husheng Yang, Xinggang Yang, Lian He
Ginkgolides are receptor antagonist of platelet activating factor with great clinical prospect, but its application is limited by its low solubility, short half-life and poor alkaline environment stability. It is difficult to solve these problems with a single drug delivery system. In this study, supersaturated self-nanoemulsifying gastric floating tablets of ginkgolides were developed through the combination of solid supersaturated self-nanoemulsifying drug delivery system (solid S-SNEDDS) and gastric retentive floating drug delivery system (GFDDS) to solve these problems of ginkgolides...
December 26, 2023: AAPS PharmSciTech
https://read.qxmd.com/read/38126777/nattokinase-encapsulated-nanomedicine-for-targeted-thrombolysis-development-improved-in-vivo-thrombolytic-effects-and-ultrasound-photoacoustic-imaging
#11
JOURNAL ARTICLE
Vishnu Priya, Samridhi, Nitesh Singh, Debabrata Dash, Madaswamy S Muthu
Nattokinase (NK), a potent thrombolytic enzyme that dissolves blood clots, is highly used in the treatment of cardiovascular disorders. However, its effective delivery remains demanding because of stability and bioavailability problems owing to its high molecular weight and proteineous nature. In this research, we have developed novel NK-loaded nontargeted liposomes (NK-LS) and targeted liposomes (RGD-NK-LS and AM-NK-LS) by the reverse phase evaporation method. The physiochemical characterizations (particle size, polydispersity index, zeta potential, and morphology) were performed by a Zetasizer, SEM, TEM, and AFM...
January 1, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/37992277/unveiling-cellular-diversity-in-the-buffalo-corneal-stroma-insights-into-telocytes-and-keratocytes-using-light-microscope-transmission-electron-microscope-and-immunofluorescence-analysis
#12
JOURNAL ARTICLE
Ahmed M Rashwan, Mohamed A M Alsafy, Samir A A El-Gendy, Ahmed A El-Mansi, Samar M Ez Elarab
Telocytes and keratocytes are important cells that maintain the structure and function of the cornea. The buffalo cornea, known for its resilience in harsh conditions, has not been extensively studied regarding the presence and role of telocytes and keratocytes. We used light microscopy, transmission electron microscopy (TEM), and immunofluorescence assays with platelet-derived growth factor receptor alpha (PDGFRα), CD34, and Vimentin markers to investigate their expression and localization in the cornea...
November 22, 2023: Microscopy and Microanalysis
https://read.qxmd.com/read/37939772/zizyphus-mauritiana-seed-extract-paving-the-way-for-next-generation-bone-constructs-with-nano-fluorohydroxyapatite-carboxymethyl-chitosan-nanocomposite-scaffold
#13
JOURNAL ARTICLE
Reshma Jolly, Mohammad Furkan, Aijaz Ahmed Khan, Syed Sayeed Ahmed, Rizwan Hasan Khan, Nahar Singh, Mohammad Shakir
This is the first study that explored the potential use of Zizyphus mauritiana seed extract (ZSE) to synthesize nano-fluorohydroxyapatite/carboxymethyl chitosan nanocomposite scaffolds at different concentrations (CFZ1, CFZ2 and CFZ3) using co-precipitation method. The proposed scaffolds showed presence of intermolecular H bonding interactions between the constituents, according to the FTIR. The mechanical studies revealed shore hardness of 72 ± 4.6 and optimal compressive modulus in case of CFZ3 [1654...
November 6, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37918254/exosomes-derived-from-mesenchymal-stromal-cells-exert-a-therapeutic-effect-on-hypoxia-induced-pulmonary-hypertension-by-modulating-the-yap1-spp1-signaling-pathway
#14
JOURNAL ARTICLE
Yao-Xin Chen, Zhi-Hua Deng, Xue-Gao, Qiang-Du, Juan-Yin, Guang-Hua Chen, Jun-Gen Li, Yi-Ming Zhao, Hao-Tian Zhang, Guo-Xing Zhang, Jin-Xian Qian
OBJECTIVE: Hypoxic pulmonary hypertension (HPH) is a progressive and life-threatening disease characterized by perivascular inflammation, pulmonary vascular remodeling, and occlusion. Mesenchymal stromal cell-derived exosomes (MSC-exo) have emerged as potential therapeutic agents due to their role in cell communication and the transportation of bioactive molecules. In this study, we aimed to investigate the therapeutic effects of MSC-exo against HPH and elucidate the underlying molecular mechanism...
October 31, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37899759/severe-preeclampsia-complicated-by-hellp-syndrome-alters-the-structure-of-hofbauer-and-syncytiotrophoblast-cells-ultrastructural-and-immunohistochemical-study
#15
JOURNAL ARTICLE
Yusuf Nergiz, Engin Deveci, Erdal Sak, Sıddık Evsen, Selçuk Tunik, Şebnem Nergiz, Fırat Aşır, Uğur Şeker
BACKGROUND: Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is generally considered to be a variant or complication of preeclampsia. It is a life-threatening obstetric complication. OBJECTIVES: To evaluate the immunohistochemistry and ultrastructural of syncytiotrophoblastand Hoffbauer cells in placental villi of patients with HELLP syndrome. METHODS: Two groups of patients with a total of 50 full-term human placentas (n = 25 in each group) were assigned as the control (normotensive) and HELLP syndrome...
October 2023: Asian Biomedicine: Research, Reviews and News
https://read.qxmd.com/read/37868955/cellular-surface-plasmon-resonance-based-detection-of-anti-hpa-1a-antibody-glycosylation-in-fetal-and-neonatal-alloimmune-thrombocytopenia
#16
JOURNAL ARTICLE
Zoltán Szittner, Arthur E H Bentlage, A Robin Temming, David E Schmidt, Remco Visser, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J E van Esch, Myrthe E Sonneveld, Erik L de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, C Ellen van der Schoot, Gestur Vidarsson
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only a fraction of pregnancies, most commonly with anti-HPA-1a antibodies. We found that in particular, the core fucosylation in the IgG-Fc tail is highly variable in anti-HPA-1a IgG, which strongly influences the binding to leukocyte IgG-Fc receptors IIIa/b (FcγRIIIa/b). Currently, gold-standard IgG-glycoanalytics rely on complicated methods (e...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37790743/high-autophagy-patterns-in-swelling-platelets-during-apheresis-platelet-storage
#17
JOURNAL ARTICLE
Lu Yu, Shifang Yu, Yunlei He, Gang Deng, Qiang Li
Platelets undergo remarkable morphological changes during storage. Platelets change into different sizes and densities and differ in their biochemistry and functions. However, the correlation between structural heterogeneity and platelet autophagy is largely unknown. The aim of this study was to investigate the autophagy process in vitro, such as routine storage of platelets, and explore the role of reactive oxygen species (ROS) involved in the regulation of platelet autophagy. The ROS and autophagy levels of platelet concentrates from apheresis platelets were evaluated through flow cytometry...
October 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37763363/influence-of-low-temperature-plasma-oxidizing-on-the-bioactivity-of-niti-shape-memory-alloy-for-medical-applications
#18
JOURNAL ARTICLE
Justyna Witkowska, Tomasz Borowski, Agnieszka Sowińska, Emilia Choińska, Dorota Moszczyńska, Jerzy Morgiel, Jerzy Sobiecki, Tadeusz Wierzchoń
The present study elucidates the impact of glow discharge oxidation within a low-temperature plasma environment on the bioactivity characteristics of an NiTi shape memory alloy. The properties of the produced surface layers, such as structure (TEM observations), surface morphology (SEM observations), chemical and phase composition (EDS and XRD measurements), wettability (optical gonimeter), and the biological response of osteoblasts and platelets to the oxidized surface compared with the NiTi alloy without a surface layer are presented...
September 6, 2023: Materials
https://read.qxmd.com/read/37743259/quasi-diamond-platelet-shaped-zinc-oxide-nanostructures-display-enhanced-antibacterial-activity
#19
JOURNAL ARTICLE
Aurora Araiza-Campos, Guillermo Herrera-Perez, Joan Salas-Leiva, Margarita Chávez Beltrán Del Río, Alejandro Aguirre-Hernández, Antonia Luna-Velasco, Dayana Salas-Leiva, Eduardo Campos-Chavez, Dariel Tovar-Ramírez, Alejandro Romo-Chacón, Erasmo Orrantia-Borunda, Francisco Paraguay-Delgado
The current study compares the antibacterial activity of zinc oxide nanostructures (neZnO). For this purpose, two bacterial strains, Escherichia coli (ATCC 4157) and Staphylococcus aureus (ATCC 29213) were challenged in room light conditions with the aforementioned materials. Colloidal and hydrothermal methods were used to obtain the quasi-round and quasi-diamond platelet-shape nanostructures. Thus, the oxygen vacancy (VO) effects on the surface of neZnO are also considered to assess its effects on antibacterial activity...
September 24, 2023: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/37714313/green-synthetized-cu-oxide-nanoparticles-properties-and-applications-for-enhancing-healing-of-wounds-infected-with-staphylococcus-aureus
#20
JOURNAL ARTICLE
Badriyah Alotaibi, Engy Elekhnawy, Thanaa A El-Masry, Asmaa Saleh, Maisra M El-Bouseary, Manal E Alosaimi, Khalid Nijr Alotaibi, Dalia H Abdelkader, Walaa A Negm
Treating wound infections is a challenging concern in various clinical settings in Egypt, especially in the increasing global problem of resistance to antimicrobials. Here, we aimed to fabricate CuO NPs via green synthesis using aqueous Yucca gigantea extract. Then, the effect of green synthesized CuO NPs on Staphylococcus aureus clinical isolates has been studied in vivo and in vitro. The aqueous extract of Yucca gigantea has been employed in our study as a scale-up approach to safely, affordably, sustainably, and practically fabricate copper oxide nanoparticles (CuO NPs)...
September 13, 2023: International Journal of Pharmaceutics
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