Huirong Huang, Shimin Zheng, Jianing Wu, Xindan Liang, Shengjie Li, Pengfei Mao, Zhinan He, Yahui Chen, Lining Sun, Xinyu Zhao, Aimin Cai, Luhui Wang, Huixiang Sheng, Qing Yao, Ruijie Chen, Ying-Zheng Zhao, Longfa Kou
Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction, synovitis, and osteophyte formation. Disease-modifying treatments for OA are currently lacking. Because inflammation mediated by an imbalance of M1/M2 macrophages in the synovial cavities contributes to OA progression, regulating the M1 to M2 polarization of macrophages can be a potential therapeutic strategy. Basing on the inherent immune mechanism and pathological environment of OA, an immunoglobulin G-conjugated bilirubin/JPH203 self-assembled nanoparticle (IgG/BRJ) is developed, and its therapeutic potential for OA is evaluated...
April 9, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)