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https://www.readbyqxmd.com/read/29774500/thalamocortical-dysconnectivity-in-premenstrual-syndrome
#1
Peng Liu, Ying Wei, Hai Liao, Yingying Fan, Ru Li, Nana Feng, Gaoxiong Duan, Demao Deng, Wei Qin
Premenstrual syndrome (PMS) is a menstrual cycle-related disorder. Although the precise pathophysiology is not fully understood, it is increasingly believed that the central nervous system plays a vital role in the development of PMS. The aim of this study is to elucidate specific functional connectivity between the thalamus and cerebral cortex. Resting-state functional magnetic resonance imaging (fMRI) data were obtained from 20 PMS patients and 21 healthy controls (HCs). Seed-based functional connectivity between the thalamus and six cortical regions of interest, including the prefrontal cortex (PFC), posterior parietal cortex, somatosensory cortex, motor cortex/supplementary motor area, temporal and occipital lobe, was adopted to identify specific thalamocortical connectivity in the two groups...
May 17, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29771194/preconception-antiphospholipid-antibodies-and-risk-of-subsequent-early-pregnancy-loss
#2
K J Gibbins, S L Mumford, L A Sjaarda, D W Branch, N J Perkins, A Ye, E F Schisterman, R M Silver
Objectives To prospectively estimate the association of preconception antiphospholipid antibodies (aPL) with subsequent pregnancy loss using a cohort design. aPL have been associated with recurrent early pregnancy loss (EPL) prior to 10 weeks in previous case-control studies. Prospective ascertainment of pregnancy loss is challenging, as most women do not seek care prior to EPL. Methods Secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial of preconception low-dose aspirin. Preconception anticardiolipin (aCL) and anti-β2-glycoprotein-I (a-β2-I) were assessed in 1208 women with one or two prior pregnancy losses and no more than two prior live births...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29769477/enzyme-immunoassays-for-water-soluble-steroid-metabolites-in-the-urine-and-feces-of-japanese-macaques-macaca-fuscata-using-a-simple-elution-method
#3
Keiko Shimizu, Keiko Mouri
A simple, non-alcoholic extraction method for measuring estrogen and progesterone metabolites in excreta using enzyme immunoassays (EIAs) was developed in Japanese macaques. The obtained detection limits of EIAs using estrone conjugates (E1 C), pregnanediol glucuronide (PdG), and estriol glucuronide (E3 G) polyclonal antibodies with cross-reactivity to urinary and fecal steroid metabolites were 6.6 pg/ml, 2.1 ng/ml, and 0.35 ng/ml, respectively. These assays allowed the determination of E1 C, PdG, and E3 G from the excreta with good reproducibility and accuracy...
May 17, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29764928/ovarian-steroid-dependence-of-endoplasmic-reticulum-stress-involvement-in-endometrial-cell-apoptosis-during-the-human-endometrial-cycle
#4
Jong Yeob Choi, Min Wha Jo, Eun Young Lee, Dong-Yun Lee, Doo Seok Choi
Endoplasmic reticulum (ER) stress is a common cellular stress response that enhances apoptosis to trigger cell death. However, recent studies have shown that estrogen suppresses apoptosis by inhibiting ER stress in some cell types, suggesting that ER stress-induced apoptosis is regulated by ovarian steroid hormones. In endometrial cells, ER stress may also be controlled by ovarian steroid hormones and could be involved in apoptosis induction during the menstrual cycle. To test this hypothesis, we elucidate whether ER stress is regulated by ovarian steroid hormones in human endometrial cells and if it is involved in apoptosis induction...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29763897/does-the-pituitary-gland-volume-change-in-polycystic-ovary-syndrome
#5
Sezen Bozkurt Koseoglu, Funda Dinc Elibol
AIMS: Polycystic ovary syndrome (PCOS) is the commonest cause of menstrual irregularity and hirsutism during reproductive age. We hypothesized in the alterations in the pituitary gland in PCOS. METHODS: We measured the volume of the pituitary gland in 39 PCOS patients and 42 age-matched healthy controls using 0.35 mm thick T1-weighted sagittal cranial images. Serum levels of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured on days 3-5 of the menstrual cycle of the participants...
May 15, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29762822/linc-ror-promotes-endometrial-cell-proliferation-by-activating-the-pi3k-akt-pathway
#6
X-Y Xu, J Zhang, Y-H Qi, M Kong, S-A Liu, J-J Hu
OBJECTIVE: To observe the expressions of Linc-ROR and proteins in the PI3K-Akt pathway in an ectopic lesion of adenomyosis. PATIENTS AND METHODS: The expression of Linc-ROR in the ectopic endometrium, eutopic endometrium, and normal endometrium of adenomyosis was detected by qRT-PCR. Western blot was used to detect the protein expressions of PI3K-Akt in endometriosis and lesion endometriosis. Cell counting kit-8 (CCK-8) assay was utilized to detect cell proliferative activity...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29759231/a-high-throughput-metabolomics-method-and-its-application-in-female-serum-samples-in-a-normal-menstrual-cycle-based-on-liquid-chromatography-mass-spectrometry
#7
Yang Ouyang, Hongbin Tong, Ping Luo, Hongwei Kong, Zhiliang Xu, Peiyuan Yin, Guowang Xu
Periodical changes of steroid hormones have a great impact on the homeostasis of the female. However, there are few studies concerning the metabolome changes during the cycle. To study the periodic metabolic changes, a female cohort was enrolled with time-series serum samples collected during a menstrual cycle. To meet the requirement of the large-scale sample analysis, a high throughput metabolomics method was established by using an efficient sample preparation on a 96 well filter plate and a rapid LC condition in 12 min, which reduces about 70% of the samples preprocessing time and 60% analysis time...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29758268/pathogenesis-of-keratoconus-the-intriguing-therapeutic-potential-of-prolactin-inducible-protein
#8
REVIEW
Rabab Sharif, Sashia Bak-Nielsen, Jesper Hjortdal, Dimitrios Karamichos
Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle...
May 11, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29755223/study-to-evaluate-the-changes-in-polycystic-ovarian-morphology-after-naturopathic-and-yogic-interventions
#9
M Ezhil Ratnakumari, N Manavalan, D Sathyanath, Y Rosy Ayda, K Reka
Background: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders in women, with a prevalence ranging from 2.2% to 26% in India. Patients with PCOS face challenges including irregular menstrual cycles, hirsutism, acne, acanthosis nigricans, obesity and infertility. 9.13% of South Indian adolescent girls are estimated to suffer from PCOS. The efficacy of Yoga & Naturopathy (Y&N) in the management of polycystic ovarian syndrome requires to be investigated...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29755146/stigma-consciousness-modulates-cortisol-reactivity-to-social-stress-in-women
#10
David Matthew Doyle, Lisa Molix
The aim of the current study was to examine whether stigma consciousness shapes cortisol responses to social stress among women in the lab. Undergraduate women ( N = 45) completed background measures and then participated in a public speaking task, with assessments of cortisol prior to the stressor as well as 20- and 40-minutes post stressor onset. Results from multilevel models revealed that women higher in stigma consciousness evidenced blunted cortisol reactivity following social stress across the study session compared to women lower in stigma consciousness...
March 2018: European Journal of Social Psychology
https://www.readbyqxmd.com/read/29750173/radiotherapy-for-adult-medulloblastoma-evaluation-of-helical-tomotherapy-volumetric-intensity-modulated-arc-therapy-and-three-dimensional-conformal-radiotherapy-and-the-results-of-helical-tomotherapy-therapy
#11
Sun Zong-Wen, Yang Shuang-Yan, Du Feng-Lei, Cheng Xiao-Long, Li Qinglin, Chen Meng-Yuan, Hua Yong-Hong, Jin Ting, Hu Qiao-Ying, Chen Xiao-Zhong, Chen Yuan-Yuan, Chen Ming
Introduction: All adult medulloblastoma (AMB) patients should be treated with craniospinal irradiation (CSI) postoperatively. Because of the long irradiation range, multiple radiation fields must be designed for conventional radiotherapy technology. CSI can be completed in only one session with helical tomotherapy (HT). We evaluated the dose of HT, volumetric intensity modulated arc therapy (VMAT), and three-dimensional conformal radiotherapy (3D-CRT) of AMB and the results of 5 cases of AMB treated with HT...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29750135/pitfalls-of-ovarian-ablative-magnetic-resonance-guided-radiation-therapy-for-refractory-endometriosis
#12
Shyama Tetar, Anna Bruynzeel, Omar Bohoudi, Theodoor Nieboer, Frank Lagerwaard
In this case presentation, we describe the challenges of performing magnetic resonance-guided radiation therapy (MRgRT) with plan adaptation in a patient with advanced endometriosis, in whom several prior therapeutic attempts were unsuccessful and extensive pelvic irradiation was regarded as being too toxic. Treatment was delivered in two sessions, first for the seemingly only active right ovary, and at a later stage for the left ovary. Some logistical problems were encountered during the preparation of the first treatment, which were subsequently optimized for the second treatment by using transvaginal ultrasound to determine the optimum time point for simulation and delivery...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29749274/can-apps-and-calendar-methods-predict-ovulation-with-accuracy
#13
Sarah Johnson, Lorrae Marriott, Michael Zinaman
OBJECTIVE: The accuracy of prediction of ovulation by cycle apps and published calendar methods was determined by comparing to true probability of ovulation. METHODS: 949 volunteers collected urine samples for one entire menstrual cycle. Luteinizing hormone was measured to assign surge day, enabling probability of ovulation to be determined across different cycle lengths. Cycle-tracking apps were downloaded. As none provided their methodology, four published calendar-based methods were also examined: standard days, rhythm, alternative rhythm, and simple calendar method...
May 11, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29744948/presynaptic-inhibition-decreases-when-estrogen-level-rises
#14
M A Hoffman, J R Doeringer, M F Norcross, S T Johnson, P E Chappell
The objective was to determine estrogen's influence on control of a skeletal muscle through measurements of motorneuron excitability (H:M ratio) and presynaptic inhibition (PI). Estrogen serum concentrations were measured at menses and ovulation of female subjects and compared to male controls. Data was analyzed from 12 females and 13 males reporting no history of knee ligament injury. Females reported regular menstrual cycles and no hormone-based contraceptive use for the previous year. Females were tested at menses (Time1) and ovulation (Time2)...
May 9, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29741912/therapeutic-effects-of-standardized-formulation-of-stachys-lavandulifolia-vahl-on-primary-dysmenorrhea-a-randomized-double-blind-crossover-placebo-controlled-pilot-study
#15
Faezeh Monji, Farshad Hashemian, Mohammad-Hossein Salehi Surmaghi, Fatemeh Mohammadyari, Saeid Ghiyaei, Alireza Soltanmohammadi
OBJECTIVES: In Iranian folklore medicine, boiled extract of Stachys lavandulifolia Vahl is reputed to have therapeutic effects in painful disorders. This study evaluated the efficacy of the standardized formulation of S. lavandulifolia Vahl in reducing pain in primary dysmenorrhea, which is known to be a common disorder with significant impact on quality of life. DESIGN: A randomized, double blind, crossover, placebo-controlled pilot study. SETTINGS/LOCATION: Bu-Ali Hospital affiliated with Tehran Medical Branch, Islamic Azad University...
May 9, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29738982/anti-m%C3%A3-llerian-hormone-levels-are-associated-with-live-birth-rates-in-art-but-the-predictive-ability-of-anti-m%C3%A3-llerian-hormone-is-modest
#16
Sara S E Alson, Leif J Bungum, Aleksander Giwercman, Emir Henic
OBJECTIVES: The aim was to evaluate the association between serum Anti-Müllerian Hormone (AMH) level and cumulative live birth rates (LBR) in patients undergoing their first in vitro fertilization (IVF) treatment cycle, and to compare serum AMH levels with Antral Follicle Count (AFC) and Ovarian Sensitivity Index (OSI) as predictors of live birth. STUDY DESIGN: A prospective cohort study of 454 patients under the age of 40 and with a regular menstrual cycle of 21-35 days, undergoing their first IVF treatment cycles between September 2010 and June 2015...
May 2, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29737900/effects-of-age-gender-and-menstrual-cycle-on-platelet-function-assessed-by-impedance-aggregometry
#17
G Berlin, M Hammar, L Tapper, N Tynngård
Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender, and phases of the menstrual cycle by use of impedance aggregometry with Multiplate. In the first part of the study, platelet function was assessed in 60 healthy individuals (30 men and 30 women) in each of three age groups (20-25, 40-45, and 60-65 years)...
May 8, 2018: Platelets
https://www.readbyqxmd.com/read/29729556/effects-of-aromatherapy-on-dysmenorrhea-a-systematic-review-and-meta-analysis
#18
Ji-Ah Song, Mi-Kyoung Lee, Eunsil Min, Mi-Eun Kim, Geraldine Fike, Myung-Haeng Hur
OBJECTIVE: Menstrual pain is not a disease, but it is a problem that periodically makes women uncomfortable during menstrual cycles. There has been a continuing effort to alleviate menstrual cramps in the medical field. Aromatherapy, one of the alternative complementary therapies, has been used as a way to alleviate menstrual cramps, but there is still little evidence of how to use it. Therefore, in this study, we tried to find and provide the evidence of relieving effects of menstrual cramps...
February 2, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29729409/subcutaneous-progesterone-for-endometrial-polyps-in-premenopausal-women-a-preliminary-retrospective-analysis
#19
Roberta Venturella, Gianmarco Miele, Katia Cefalì, Daniela Lico, Pietro D'Alessandro, Bruno Arduino, Annalisa Di Cello, Fulvio Zullo, Costantino Di Carlo
STUDY OBJECTIVE: To investigate the effects of three cycles of subcutaneous progesterone, administered during the luteal phase, on the regression rate of symptomatic and asymptomatic endometrial polyps in premenopausal woman. DESIGN: A retrospective study (Canadian Task Force classification II-2). SETTING: A Department of Obstetrics and Gynecology in a university hospital. PATIENTS: One hundred twenty-seven reproductive-aged women presented with endometrial polyps from January to December 2016...
May 2, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29728203/migraine-throughout-the-female-reproductive-life-cycle
#20
REVIEW
Stephanie S Faubion, Pelin Batur, Anne H Calhoun
By the end of their reproductive life cycle, roughly 40% of women have experienced migraine. Women have certain times of vulnerability for migraine that relate to abrupt declines in estrogen levels. Specifically, the prevalence of migraine is higher after menarche, during menstruation, during the postpartum period, and during perimenopause, but it is commonly lower during the second and third trimesters of pregnancy and the postmenopausal years. Therapeutic strategies for migraine management include hormonal manipulation aimed at eliminating or minimizing the decreases in estrogen that trigger the especially severe menstrual-related attacks...
May 2018: Mayo Clinic Proceedings
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