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https://www.readbyqxmd.com/read/28811691/association-of-prooxidant-antioxidant-balance-with-clinical-and-laboratory-parameters-and-its-relation-to-different-drug-regimens-in-polycystic-ovary-syndrome-women-with-normal-bmi
#1
Niloofar Heshmati, Shoaleh Shahgheibi, Bahram Nikkhoo, Sabrieh Amini, Mohammad Abdi
Polycystic ovarian syndrome is one of the most common hormonally leading cause infertility disorders. The effect of oxidant-antioxidant imbalance on disease progression has been studied in many disorders. The present study was aimed to evaluate prooxidant-antioxidant balance (PAB) in patients with polycystic ovarian syndrome compared to healthy subjects. We also studied the possible effect of treatment with available drugs on serum PAB. In this case-control study 100 polycystic ovary syndrome (PCOS) patients and 100 healthy individuals were enrolled in the study...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28795075/the-effect-of-menstrual-cycle-and-contraceptives-on-acl-injuries-and-laxity-a-systematic-review-and-meta-analysis
#2
REVIEW
Simone D Herzberg, Makalapua L Motu'apuaka, William Lambert, Rongwei Fu, Jacqueline Brady, Jeanne-Marie Guise
BACKGROUND: Women are at substantially greater risk for anterior cruciate ligament (ACL) injuries than are men. PURPOSE: To conduct a systematic review and meta-analysis of the literature to clarify the effect of the menstrual cycle and contraceptives on the laxity of and noncontact injuries to the ACL. STUDY DESIGN: Systematic review; Level of evidence, 4. METHODS: Searches were conducted using MEDLINE (1946-August 2016), the Cochrane Library Database, clinical trial registries, and related reference lists...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28794543/synchronizing-pharmacotherapy-in-acne-with-review-of-clinical-care
#3
REVIEW
Sarvajnamurthy Aradhya Sacchidanand, Koushik Lahiri, Kiran Godse, Narendra Gajanan Patwardhan, Anil Ganjoo, Rajendra Kharkar, Varsha Narayanan, Dhammraj Borade, Lyndon D'souza
Acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of Propionibacterium acnes, and inflammation. Several acne mono-treatment and combination treatment regimens are available and prescribed in the Indian market, ranging from retinoids, benzoyl peroxide (BPO), anti-infectives, and other miscellaneous agents. Although standard guidelines and recommendations overview the management of mild, moderate, and severe acne, relevance and positioning of each category of pharmacotherapy available in Indian market are still unexplained...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28794095/the-majority-of-irregular-menstrual-cycles-in-adolescence-are-ovulatory-results-of-a-prospective-study
#4
Alexia S Peà A, Dorota A Doherty, Helen C Atkinson, Martha Hickey, Robert J Norman, Roger Hart
PURPOSE: While ovulation is most likely to occur in adolescent girls with regular menstrual cycles, there are limited data on the incidence of ovulation in girls with irregular menstrual cycles in early postmenarcheal years. The aim of the study was to evaluate the presence of ovulation in healthy postmenarcheal girls with irregular menstrual cycles. METHODS, DESIGN AND SUBJECTS: Prospective cohort study over 12 weeks including 40 healthy postmenarcheal girls recruited from the population-based cohort of adolescents from Western Australian Pregnancy Cohort (Raine) Study with irregular menstrual cycles defined by either menstrual cycles <21 days or >35 days in duration or cycle length that varied from month to month by >4 days according to menstrual diaries...
August 9, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28792788/age-related-decline-in-amh-is-assay-dependent-limiting-clinical-interpretation-of-repeat-amh-measures-across-the-reproductive-lifespan
#5
Lukasz Plociennik, Scott M Nelson, Aron Lukaszuk, Michal Kunicki, Agnieszka Podfigurna, Blazej Meczekalski, Krzysztof Lukaszuk
PURPOSE: The aim of the study was to determine whether the assays exhibit an interaction with age and exhibit heterogeneous age related declines in AMH. Apart of chronological age, AMH variation was investigated with relation to menstrual cycle day (MCD). The goal implicates two questions: Are distributions of AMH concentrations homogenous after adjustment for the specific AMH assay? Does age-assay product has an effect on AMH depletion? METHODS: The study was conducted by examining results of AMH tests performed for 12,917 women with four types of AMH assays: Immunotech I generation kit (IMI, 4016 samples), Beckman Coulter II generation kit RUO (BCII RUO, 3430 samples), Beckman Coulter II generation kit with IVD certificate (BCII IVD, 830 samples), and Ansh Labs I generation kit (AnshLabs, 4641 samples)...
August 9, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28789706/small-leucine-rich-proteoglycans-slrps-in-the-endometrium-of-polycystic-ovary-syndrome-women-a-pilot-study
#6
Ricardo Santos Simões, José Maria Soares-Jr, Manuel J Simões, Helena B Nader, Maria Cândida P Baracat, Gustavo Arantes R Maciel, Paulo C Serafini, Ricardo Azziz, Edmund C Baracat
BACKGROUND: Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. METHODS: In a cross section study a total of 20 endometrial samples were collected from 10 patients with PCOS and 10 ovulatory women during their proliferative (pre-ovulatory) phase...
August 8, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28789684/blood-lead-cadmium-and-mercury-in-relation-to-homocysteine-and-c-reactive-protein-in-women-of-reproductive-age-a-panel-study
#7
Anna Z Pollack, Sunni L Mumford, Lindsey Sjaarda, Neil J Perkins, Farah Malik, Jean Wactawski-Wende, Enrique F Schisterman
BACKGROUND: To examine the relationship between cadmium, lead, and mercury concentrations with high-sensitivity C-reactive protein (hs-CRP) and homocysteine in women. METHODS: Metals were measured at enrollment in whole blood. Homocysteine and hs-CRP were measured in one (N = 9) or two (N = 250) menstrual cycles up to 3 and 8 times per cycle, respectively. Linear mixed models with inverse probability of exposure weights to account for time varying confounding were used and models were stratified by dietary and serum vitamin status (dietary: vitamin B6, B12, folate; serum: folate)...
August 8, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28778107/-current-aspects-of-premenstrual-dysphoric-disorder-a-review
#8
Theresa Beddig, Christine Kühner
This narrative review presents current aspects of diagnosis, epidemiology, aetiology and therapy of Premenstrual Dysphoric Disorder (PMDD). PMDD is characterised by emotional, physical and behavioral changes during the premenstrual phase of the menstrual cycle associated with clinically significant distress and marked impairment of psychosocial functioning. Due to its cardinal symptoms (e. g. marked affect lability and irritability), its specific cycle-dependent course and high symptom-specific stability, PMDD has been outlined as a new diagnostic category in the chapter on depressive disorders in the fifth edition of the "Diagnostic and Statistical Handbook of Mental Disorders"...
August 4, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28770353/comparison-of-the-effect-between-pioglitazone-and-metformin-in-treating-patients-with-pcos-a-meta-analysis
#9
REVIEW
Yifeng Xu, Yanxiang Wu, Qin Huang
BACKGROUND: Pioglitazone was used to treat patients of PCOS in many researches, but the treatment has not been recognized by public or recommended by all the guidelines. METHOD: We conducted a meta-analysis of the related literatures to objectively evaluate the clinical effectiveness and safety by comparing pioglitazone with metformin administrated by PCOS patients. Searches were performed in Cochrane Library, EMBASE and PubMed (last updated December 2016). RESULTS: Eleven studies among 486 related articles were identified through searches...
August 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28766085/influence-of-sex-menstrual-cycle-and-oral-contraceptives-on-the-cerebrovascular-response-to-paced-deep-breathing
#10
Misha Nili, Syed Abidi, Stephania Serna, Simon Kim, Heather Edgell
PURPOSE: Deep breathing assesses autonomic function; however, many researchers/clinicians do not account for hyperventilation, brain blood flow or blood pressure. METHODS: Men and women (with/without oral contraceptives) participated. women participated during low and high hormone phases of the menstrual cycle. Blood pressure, end-tidal carbon dioxide, middle cerebral artery velocity and cerebrovascular resistance were assessed. RESULTS: Deep breathing decreased end-tidal carbon dioxide and middle cerebral artery velocity while increasing cerebrovascular resistance in all participants; blood pressure decreased in men...
August 1, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28762102/weight-loss-and-appetite-control-in-women
#11
REVIEW
Luzia Jaeger Hintze, Salma Mahmoodianfard, Coralie Bonaparte Auguste, Éric Doucet
PURPOSE OF REVIEW: The aim of this review is to describe and discuss weight loss-induced variations in appetite in women and factors responsible for these changes. RECENT FINDINGS: Studies have shown postweight loss increases in fasting and postprandial appetite in individuals engaged in weight loss trials, especially in women. Similarly, appetite-related peptides associated to the homeostatic control of feeding, such as leptin, ghrelin and peptide YY, were also found to be altered in way that promotes increased appetite after weight loss interventions...
July 31, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28761298/three-cases-of-autoimmune-progesterone-dermatitis
#12
Hye Rin You, Sook Jung Yun, Sung Jin Kim, Seung-Chul Lee, Young Ho Won, Jee-Bum Lee
Autoimmune progesterone dermatitis is a rare cyclic premenstrual reaction to progesterone produced during the luteal phase of the menstrual cycle. The clinical symptoms of autoimmune progesterone dermatitis overlap with other forms of dermatosis such as erythema multiforme, eczema, fixed drug eruption, urticaria, and angioedema. We experienced 3 cases of autoimmune progesterone dermatitis. All patients had a recurrent history of monthly skin eruptions. Skin lesions normally began a few days before menstruation and resolved a few days later...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28760794/comparison-of-a-freeze-all-strategy-including-gnrh-agonist-trigger-versus-a-fresh-transfer-strategy-including-hcg-trigger-in-assisted-reproductive-technology-art-a-study-protocol-for-a-randomised-controlled-trial
#13
Sacha Stormlund, Kristine Løssl, Anne Zedeler, Jeanette Bogstad, Lisbeth Prætorius, Henriette Svarre Nielsen, Mona Bungum, Sven O Skouby, Anne Lis Mikkelsen, Anders Nyboe Andersen, Christina Bergh, Peter Humaidan, Anja Pinborg
INTRODUCTION: Pregnancy rates after frozen embryo transfer (FET) have improved in recent years and are now approaching or even exceeding those obtained after fresh embryo transfer. This is partly due to improved laboratory techniques, but may also be caused by a more physiological hormonal and endometrial environment in FET cycles. Furthermore, the risk of ovarian hyperstimulation syndrome is practically eliminated in segmentation cycles followed by FET and the use of natural cycles in FETs may be beneficial for the postimplantational conditions of fetal development...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28758509/polycystic-ovary-syndrome-among-obese-adolescents
#14
Marina Ybarra, Ruth Rocha Franco, Louise Cominato, Raissa Beltrão Sampaio, Silvia Maria Sucena da Rocha, Durval Damiani
BACKGROUND AND AIMS: In adolescence and obesity, the pathophysiology of polycystic ovary syndrome (PCOS) is very difficult to distinguish. We aimed to assess the diagnosis of PCOS in the population of obese adolescent. METHODS: Cross-sectional study. SETTING: Pediatric Endocrinology Weight and Management Clinic from Children's Institute, São Paulo, Brazil. PARTICIPANTS: Forty-nine post-menarcheal obese adolescents with mean age of 14...
July 29, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28757766/clear-cell-carcinoma-arising-from-scar-endometriosis-a-case-report-and-literature-review
#15
Chun-Jui Wei, Shu-Han Huang
Scar endometriosis is uncommon and defined as the presence of ectopic endometrial glands in abdominal soft tissues after a gynecological operation. Malignant transformation has been reported but remains rare. Carcinogenesis occurs in ectopic endometrial tissue with repeated hormone stimulation during the menstrual cycle. We present a case of clear cell carcinoma directly arising from scar endometriosis after a cesarean section and review all 16 cases reported.
January 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28754906/kras-activation-and-over-expression-of-sirt1-bcl6-contributes-to-the-pathogenesis-of-endometriosis-and-progesterone-resistance
#16
Jung-Yoon Yoo, Tae Hoon Kim, Asgerally T Fazleabas, Wilder A Palomino, Soo Hyun Ahn, Chandrakant Tayade, David P Schammel, Steven L Young, Jae-Wook Jeong, Bruce A Lessey
Endometriosis is an inflammatory condition that is associated with progesterone resistance and cell proliferation, resulting in pain, infertility and pregnancy loss. We previously demonstrated phosphorylation of STAT3 in eutopic endometrium of infertile women with this disorder leading to over-expression of the oncogene BCL6 and stabilization of hypoxia-induced factor 1 alpha (HIF-1α). Here we report coordinated activation of KRAS and over-expression of Sirtuin 1 (SIRT1), a histone deacetylase and gene silencer, in the eutopic endometrium from women with endometriosis throughout the menstrual cycle...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28752719/serum-estradiol-concentration-estradiol-to-progesterone-ratio-and-sputum-il-5-and-il-8-concentrations-are-increased-in-luteal-phase-of-the-menstrual-cycle-in-perimenstrual-asthma-patients
#17
A Semik-Orzech, S Skoczyński, W Pierzchała
Background. The results of the research on perimenstrual asthma (PMA) pathophysiology are inconsistent, and the role of sex hormones remains inconclusive. The aim of the study was to evaluate the influence of serum sex steroid (and other) hormones concentrations on lower airway inflammation of PMA patients. Methods. Thirty-three women of childbearing age diagnosed as: PMA (n = 13), non-PMA asthmatics (n = 10), and healthy controls (n = 10) were prospectively followed for 12 weeks over 2 consecutive menstrual cycles...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28751855/interactive-effects-of-dopamine-baseline-levels-and-cycle-phase-on-executive-functions-the-role-of-progesterone
#18
Esmeralda Hidalgo-Lopez, Belinda Pletzer
Estradiol and progesterone levels vary along the menstrual cycle and have multiple neuroactive effects, including on the dopaminergic system. Dopamine relates to executive functions in an "inverted U-shaped" manner and its levels are increased by estradiol. Accordingly, dopamine dependent changes in executive functions along the menstrual cycle have been previously studied in the pre-ovulatory phase, when estradiol levels peak. Specifically it has been demonstrated that working memory is enhanced during the pre-ovulatory phase in women with low dopamine baseline levels, but impaired in women with high dopamine baseline levels...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28750644/a-retrospective-study-of-reproductive-outcomes-after-fertility-sparing-surgery-and-postoperative-adjuvant-chemotherapy-in-malignant-ovarian-germ-cell-tumors-and-sex-cord-stromal-tumors
#19
Ning Zhang, Ruifang Chen, Keqin Hua, Ying Zhang
BACKGROUND: To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). METHODS: Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed...
July 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28741624/hormonal-cycle-and-contraceptive-effects-on-amygdala-and-salience-resting-state-networks-in-women-with-previous-affective-side-effects-on-the-pill
#20
Jonas Engman, Inger Sundström Poromaa, Lena Moby, Johan Wikström, Mats Fredrikson, Malin Gingnell
The mechanisms linking ovarian hormones to negative affect are poorly characterized, but important clues may come from the examination of the brain's intrinsic organization. Here, we studied the effects of both the menstrual cycle and oral contraceptives (OCs) on amygdala and salience network resting-state functional connectivity using a double-blind, randomized, and placebo-controlled design. Hormone levels, depressive symptoms, and resting-state functional connectivity were measured in 35 healthy women (24...
June 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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