Victoria Light, Sherri Lee Jones, Elham Rahme, Katerine Rousseau, Sterre de Boer, Lisa Vermunt, Mahdie Soltaninejad, Charlotte Teunissen, Yolande Pijnenburg, Simon Ducharme, For Signature Consortium
BACKGROUND: Symptoms of behavioral variant frontotemporal dementia (bvFTD) overlap with primary psychiatric disorders (PPD) making diagnosis challenging. Serum neurofilament light (sNfL) is a candidate biomarker to distinguish bvFTD from PPD, but large-scale studies in PPD are lacking. OBJECTIVE: Determine factors that influence sNfL from a large database of PPD patients, and test its diagnostic accuracy. DESIGN, SETTINGS, SUBJECTS, MEASUREMENTS: Clinical data of people aged 40-81 were obtained from healthy subjects (n = 69), and patients with PPD (n = 848) or bvFTD (n = 82)...
March 24, 2024: American Journal of Geriatric Psychiatry