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https://www.readbyqxmd.com/read/29444253/hiv-1-genotypic-resistance-testing-using-the-vela-automated-next-generation-sequencing-platform
#1
Stéphanie Raymond, Florence Nicot, Romain Carcenac, Caroline Lefebvre, Nicolas Jeanne, Karine Saune, Pierre Delobel, Jacques Izopet
Objectives: To evaluate the diagnostic performance of the Vela next-generation sequencing (NGS) system in conjunction with the Sentosa SQ HIV Genotyping Assay for genotyping HIV-1. Methods: Plasma RNA was extracted and templates prepared with the Sentosa SX instrument before sequencing the HIV-1 polymerase on the Sentosa SQ301 Sequencer (PGM IonTorrent). The Vela NGS System was compared with direct sequencing and the 454 GS-FLX (Roche) and MiSeq (Illumina) systems for genotypic resistance testing on clinical samples...
February 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29443541/a-method-for-choosing-the-best-samples-for-mars-sample-return
#2
Peter R Gordon, Mark A Sephton
Success of a future Mars Sample Return mission will depend on the correct choice of samples. Pyrolysis-FTIR can be employed as a triage instrument for Mars Sample Return. The technique can thermally dissociate minerals and organic matter for detection. Identification of certain mineral types can determine the habitability of the depositional environment, past or present, while detection of organic matter may suggest past or present habitation. In Mars' history, the Theiikian era represents an attractive target for life search missions and the acquisition of samples...
February 14, 2018: Astrobiology
https://www.readbyqxmd.com/read/29442478/a-clinical-audit-diagnostic-and-epidemiological-evaluation-of-the-adrenal-incidentaloma-ai
#3
Vincenzo Nuzzo, Tiziana Attardo, Giuseppe Augello, Davide Brancato, Salvatore Camerlingo, Clelia Canale, Federica Coretti, Alessandro Franco, Francesco Giacometti, Maurizio Gambacorta, Massimo Loreno, Ada Maffettone, Vincenzo Provenzano, Alfonso Zuccoli
Audit is a clinical instrument of government characterized by a whole process of evaluation inter pares to improve medical behaviors in the clinical practice. Different endocrinopathies are underestimated in the clinical and diagnostics practice but they can be a real problem in patients admitted in the departments of Internal Medicine. The Adrenal Incidentaloma (AI) is an accidental discovery with an incidence equal to 4% in radiologic studies but it's rarely considereted in the internal disorders. In the departments of Internal Medicine are hospitalized each year approximately 1...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29440656/gold-nanoparticle-based-rapid-detection-and-isolation-of-cells-using-ligand-receptor-chemistry
#4
Pradipta Ranjan Rauta, Pavan M Hallur, Aditya Chaubey
Identification and isolation of low-frequency cells of interest from a heterogeneous cell mixture is an important aspect of many diagnostic applications (including enumeration of circulating tumor cells) and is integral to various assays in (cancer) biology. Current techniques typically require expensive instrumentation and are not amenable to high throughput. Here, we demonstrate a simple and effective platform for cell detection and isolation using gold nanoparticles (Au NPs) conjugated with hyaluronic acid (HA) i...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439338/multi-parametric-classification-of-vascular-cognitive-impairment-and-dementia-the-impact-of-diverse-cerebrovascular-injury-biomarkers
#5
Brittany Lang, Mark S Kindy, F Andrew Kozel, Susan K Schultz, Saeid Taheri
Vascular cognitive impairment and dementia (VCID) is a diagnostic term applied to cognitively impaired individuals with heterogeneous cerebrovascular conditions affecting large and/or small vessels. Individual biomarkers have been identified as instrumental in relating VCID to specific underlying pathologies to better characterize this syndrome. Emerging research to refine panels of biomarkers will increase classification sensitivity and specificity. Refined VCID clustering based on the severity and pathology of vascular injury will permit the development of optimal prevention and treatment strategies...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29438767/diagnosis-and-management-of-pemphigus-recommendations-by-an-international-panel-of-experts
#6
Dedee F Murrell, Sandra Peña, Pascal Joly, Branka Marinovic, Takashi Hashimoto, Luis A Diaz, Animesh A Sinha, Aimee S Payne, Maryam Daneshpazhooh, Rüdiger Eming, Marcel F Jonkman, Daniel Mimouni, Luca Borradori, Soo-Chan Kim, Jun Yamagami, Julia S Lehman, Marwah Adly Saleh, Donna A Culton, Annette Czernik, John J Zone, David Fivenson, Hideyuki Ujiie, Katarzyna Wozniak, Ayşe Akman-Karakaş, Philippe Bernard, Neil J Korman, Frédéric Caux, Kossara Drenovska, Catherine Prost-Squarcioni, Snejina Vassileva, Ron J Feldman, Adela Rambi Cardones, Johann Bauer, Dimitrios Ioannides, Hana Jedlickova, Francis Palisson, Aikaterini Patsatsi, Soner Uzun, Savas Yayli, Detlef Zillikens, Masayuki Amagai, Michael Hertl, Enno Schmidt, Valeria Aoki, Sergei A Grando, Hiroshi Shimizu, Sharon Baum, Guiseppe Cianchini, Claudio Feliciani, Pilar Iranzo, Jose M Mascaró, Cezary Kowalewski, Russell Hall, Richard Groves, Karen E Harman, M Peter Marinkovich, Emanual Maverakis, Victoria P Werth
BACKGROUND: Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management, OBJECTIVE: We now present results from a subsequent Delphi consensus to broaden the generalizability of recommendations. METHODS: A preliminary survey, based on the European Dermatology Forum (EDF) and the European Academy of Dermatology and Venereology (EADV) guidelines, was sent to a panel of international experts to determine the level of consensus...
February 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29438475/detecting-infections-rapidly-and-easily-for-candidemia-trial-part-2-direct2-a-prospective-multicenter-study-of-the-t2candida-panel
#7
Cornelius J Clancy, Peter G Pappas, Jose Vazquez, Marc A Judson, Dimitrios P Kontoyiannis, George R Thompson, Kevin W Garey, Annette Reboli, Richard N Greenberg, Senu Apewokin, G Marshall Lyon, Luis Ostrosky-Zeichner, Alan H B Wu, Ellis Tobin, M Hong Nguyen, Angela M Caliendo
Background: Blood cultures are approximately 50% sensitive for diagnosing invasive candidiasis. The T2Candida nanodiagnostic panel uses T2 magnetic resonance and a dedicated instrument to detect Candida directly within whole blood samples. Methods: Patients with Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, or Candida krusei candidemia were identified at 14 centers using diagnostic blood cultures (dBCs). Follow-up blood samples were collected concurrently for testing by T2Candida and companion cultures (cBCs)...
February 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29436794/the-follow-up-role-of-the-vestibular-evoked-myogenic-potential-test-in-meniere-s-disease
#8
Nasrin Yazdani, Farzaneh Nejadian, Nima Rezazadeh, Reza Hoseinabadi, Ebrahim Karimi, Reza Gharibi, Sasan Dabiri
Despite some proposed roles for the diagnostic impact of the cervical vestibular evoked myogenic potential test in the patients with Meniere's disease, the role of this test as an objective instrument in following up the patients with Meniere's disease who underwent. Intratympanic steroid injection is not cleared. In a prospective study, thirty-one adult patients with definite one-sided Meniere's disease with vertigo as main complaint refractory to medical treatments for three months, were selected. Patients underwent three times of intratympanic dexamethasone injection with one-week intervals...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29435802/measuring-health-related-quality-of-life-hrqol-in-community-and-facility-based-care-settings-with-the-interrai-assessment-instruments-development-of-a-crosswalk-to-hui3
#9
John P Hirdes, Julie Bernier, Rochelle Garner, Philippe Finès, Micaela Jantzi
BACKGROUND: Health-related quality of life (HRQoL) measures are of interest because they can be used to describe health of populations and represent a broader health outcome for population health analyses than mortality rates or life expectancy. The most widely used measure of HRQoL for deriving estimates of health-adjusted life expectancy is the Health Utilities Index Mark 3 (HUI3). The HUI3 is available in most national surveys administered by Statistics Canada, and has been used as part of a microsimulation model to examine the impact of neurological conditions over the life course...
February 12, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29435801/cosmin-guideline-for-systematic-reviews-of-patient-reported-outcome-measures
#10
C A C Prinsen, L B Mokkink, L M Bouter, J Alonso, D L Patrick, H C W de Vet, C B Terwee
PURPOSE: Systematic reviews of patient-reported outcome measures (PROMs) differ from reviews of interventions and diagnostic test accuracy studies and are complex. In fact, conducting a review of one or more PROMs comprises of multiple reviews (i.e., one review for each measurement property of each PROM). In the absence of guidance specifically designed for reviews on measurement properties, our aim was to develop a guideline for conducting systematic reviews of PROMs. METHODS: Based on literature reviews and expert opinions, and in concordance with existing guidelines, the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) steering committee developed a guideline for systematic reviews of PROMs...
February 12, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29431479/the-habitability-of-proxima-centauri-b-environmental-states-and-observational-discriminants
#11
Victoria S Meadows, Giada N Arney, Edward W Schwieterman, Jacob Lustig-Yaeger, Andrew P Lincowski, Tyler Robinson, Shawn D Domagal-Goldman, Russell Deitrick, Rory K Barnes, David P Fleming, Rodrigo Luger, Peter E Driscoll, Thomas R Quinn, David Crisp
Proxima Centauri b provides an unprecedented opportunity to understand the evolution and nature of terrestrial planets orbiting M dwarfs. Although Proxima Cen b orbits within its star's habitable zone, multiple plausible evolutionary paths could have generated different environments that may or may not be habitable. Here, we use 1-D coupled climate-photochemical models to generate self-consistent atmospheres for several evolutionary scenarios, including high-O2, high-CO2, and more Earth-like atmospheres, with both oxic and anoxic compositions...
February 12, 2018: Astrobiology
https://www.readbyqxmd.com/read/29430928/luminescent-device-for-detection-of-oxidative-stress-biomarker-in-artificial-urine
#12
Gopal Ammanath, Umit Hakan Yildiz, Alagappan Palaniappan, Bo Liedberg
A luminescent paper device for visual detection of oxidative stress biomarker is reported. The assay platform consists of a polyvinylidene fluoride (PVDF) membrane impregnated with poly(3-alkoxy-4-methylthiophene) (PT) for colorimetric sensing. 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker associated with oxidative stress, is used as a model system for validating the proposed methodology. The sensing strategy is based on monitoring the changes in optical properties of PT associated with its conformational changes upon interaction with an aptamer in the presence and in the absence of 8-OHdG...
February 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29430794/liebowitz-social-anxiety-scale-lsas-optimal-cut-points-for-remission-and-response-in-a-german-sample
#13
M von Glischinski, U Willutzki, U Stangier, W Hiller, J Hoyer, E Leibing, F Leichsenring, G Hirschfeld
The Liebowitz Social Anxiety Scale (LSAS) is the most frequently used instrument to assess social anxiety disorder (SAD) in clinical research and practice. Both a self-reported (LSAS-SR) and a clinician-administered (LSAS-CA) version are available. The aim of the present study was to define optimal cut-off (OC) scores for remission and response to treatment for the LSAS in a German sample. Data of N = 311 patients with SAD were used who had completed psychotherapeutic treatment within a multicentre randomized controlled trial...
February 11, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29427476/the-accuracy-and-prognostic-value-of-point-of-care-ultrasound-for-nephrolithiasis-in-the-emergency-department-a-systematic-review-and-meta-analysis
#14
Charles Wong, Braden Teitge, Marshall Ross, Paul Young, Helen Lee Robertson, Eddy Lang
INTRODUCTION: Point-of-care ultrasound (POCUS) has been suggested as an initial investigation in the management of renal colic. Our objectives were: 1) to determine the accuracy of POCUS for the diagnosis of nephrolithiasis, and 2) to assess its prognostic value in the management of renal colic. METHODS: The review protocol was registered to the PROSPERO database (CRD42016035331). An electronic database search of MEDLINE, EMBASE, and PubMed was conducted utilizing subject headings, keywords, and synonyms that address our research question...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29426656/a-rapid-lateral-flow-immunoassay-for-serological-diagnosis-of-pertussis
#15
Teppo Salminen, Aapo Knuutila, Alex-Mikael Barkoff, Jussi Mertsola, Qiushui He
Current serological diagnosis of pertussis is usually done by ELISA. However, the ELISAs are often central-laboratory based, require trained staff and have long turnaround times. A rapid point-of-care (POC) assay for pertussis serology would aid in both diagnosis and surveillance of the disease. While lateral flow immunoassays (LFIA) are simple to use and ideal for point-of-care diagnostics, they were limited to qualitative assays until recently. In this study, we developed a quantitative LFIA with fluorescent Eu-nanoparticle reporters for the detection of anti-pertussis toxin (PT) IgG...
February 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29426009/clinimetrics-of-ultrasound-pathologies-in-osteoarthritis-systematicliterature-review-and-meta-analysis
#16
REVIEW
Win Min Oo, James M Linklater, Matthew Daniel, Simo Saarakkala, Jonathan Samuels, Philip G Conaghan, Helen I Keen, Leticia A Deveza, David J Hunter
OBJECTIVE: The aims of this study were to systematically review clinimetrics of commonly assessed ultrasound pathologies in knee, hip and hand osteoarthritis (OA), and to conduct a meta-analysis for each clinimetric. METHODS: MEDLINE, EMBASE, and Cochrane Library databases were searched from their inceptions to September 2016. According to the OMERACT Instrument Selection Algorithm, data extraction focused on ultrasound technical features and performance metrics...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29424096/low-education-and-lack-of-spousal-relationship-are-associated-with-dementia-in-older-adults-with-diabetes-mellitus-in-nigeria
#17
Abdulkareem J Yusuf, Olusegun Baiyewu, Adamu G Bakari, Sani B Garko, Mohammed E-B Jibril, Aishatu M Suleiman, Haruna M Muktar, Micheal A Amedu
BACKGROUND: The relationship between dementia and type 2 diabetes mellitus (T2DM) in older adults is well established in the literature. However, there have been few studies on this relationship in older adults living in low- and middle-income countries, and most demographic projections predict that older adult population will increase substantially in these regions by 2050. METHODS: In this study, older adults with T2DM attending a tertiary health facility were examined and compared with community-dwelling older adults without T2DM...
February 8, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29422926/reliability-and-validity-of-a-new-comprehensive-tool-for-assessing-challenging-behaviors-in-autism-spectrum-disorder
#18
Johanna Inhyang Kim, Min-Sup Shin, Youngsun Lee, Hyojung Lee, Hee Jeong Yoo, Soo-Yeon Kim, Hyewon Kim, Soo-Jin Kim, Bung-Nyun Kim
Objective: The purpose of this study was to examine the validity and reliability of the Korean Comprehensive Scale for the Assessment of Challenging Behavior in Developmental Disorders (K-CSCB). Methods: In total, the parents of 189 patients with autism spectrum disorder (ASD) and 168 controls completed the K-CSCB, the Behavior Problems Inventory (BPI) and Child Behavior Checklist (CBCL). The reliability and validity of the K-CSCB was investigated. Results: The K-CSCB was found to be a reliable instrument (Cronbach's α=0...
January 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29416845/ehmt1-mosaicism-in-apparently-unaffected-parents-is-associated-with-autism-spectrum-disorder-and-neurocognitive-dysfunction
#19
Anneke de Boer, Karlijn Vermeulen, Jos I M Egger, Joost G E Janzing, Nicole de Leeuw, Hermine E Veenstra-Knol, Nicolette S den Hollander, Hans van Bokhoven, Wouter Staal, Tjitske Kleefstra
Background: Genetic mosaicism is only detected occasionally when there are no obvious health or developmental issues. Most cases concern healthy parents in whom mosaicism is identified upon targeted testing of a genetic defect that was initially detected in their children. A germline genetic defect affecting the euchromatin histone methyltransferase 1 (EHMT1) gene causes Kleefstra syndrome, which is associated with the typical triad of distinct facial appearance, (childhood) hypotonia, and intellectual disability...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29414409/better-diagnostic-accuracy-of-neuropathy-in-obesity-a-new-challenge-for-neurologists
#20
Brian C Callaghan, Rong Xia, Evan Reynolds, Mousumi Banerjee, Charles Burant, Amy Rothberg, Rodica Pop-Busui, Emily Villegas-Umana, Eva L Feldman
OBJECTIVE: To determine the comparative diagnostic characteristics of neuropathy measures in an obese population. METHODS: We recruited obese participants from the University of Michigan's Weight Management Program. Receiver operative characteristic analysis determined the area under the curve (AUC) of neuropathy measures for distal symmetric polyneuropathy (DSP), small fiber neuropathy (SFN), and cardiovascular autonomic neuropathy (CAN). The best test combinations were determined using stepwise and Score subset selection models...
March 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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