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https://www.readbyqxmd.com/read/28820721/risk-factors-associated-with-blood-exposure-for-sporadic-hepatitis-e-in-dhaka-bangladesh
#1
Hossain M S Sazzad, Stephen P Luby, Alain B Labrique, Saleem Kamili, Tonya M Hayden, Nourine A Kamili, Chong-Gee Teo, Emily S Gurley
Fecal contamination of drinking water is associated with large hepatitis E virus (HEV) outbreaks of genotypes 1 and 2 in endemic areas. Sporadic transmission of HEV genotypes 3 and 4 in high-income countries has been associated with exposure to blood and animal contact. The objective of the study was to identify the risk factors for hepatitis E and the genotype(s) causing sporadic hepatitis E in Dhaka, Bangladesh. We selected, from a diagnostic center in Dhaka between November 2008 and November 2009, cases presenting with jaundice and anti-HEV IgM antibodies and age-matched controls were defined as those with no history of jaundice and normal blood test results...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820421/-the-role-of-papillomavirus-infection-in-the-development-of-background-disease-of-the-cervix
#2
S Muslimova
Papillomavirus infection is one of the most common sexually transmitted infections. The aim of the study was to study the etiologic significance of the papillomavirus infection in the development of background diseases of the cervix and neoplasia. Under observation were 62 patients aged 18 to 55 years infected with human papillomavirus. All patients underwent complex clinical and anamnestic, laboratory and instrumental examination. Also, a review and advanced colposcopy was performed. As a result of the study, 53 (85...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28818785/a-single-tube-approach-for-in-vitro-diagnostics-using-diatomaceous-earth-and-optical-sensor
#3
Fei Zhao, Bonhan Koo, Huifang Liu, Choong Eun Jin, Yong Shin
Versatile, simple and efficient sample preparation is desirable for point-of-care testing of emerging diseases such as zoonoses, but current sample preparation assays are insensitive, labour-intensive and time-consuming and require multiple instruments. We developed a single-tube sample preparation approach involving direct pathogen enrichment and extraction from human specimens using diatomaceous earth (DE). Amine-modified DE was used to directly enrich a zoonotic pathogen, Brucella, in a large sample volume...
August 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28816307/quantum-cascade-lasers-qcls-in-biomedical-spectroscopy
#4
REVIEW
Andreas Schwaighofer, Markus Brandstetter, Bernhard Lendl
Quantum cascade lasers (QCL) are the first room temperature semiconductor laser source for the mid-IR spectral region, triggering substantial development for the advancement of mid-IR spectroscopy. Mid-IR spectroscopy in general provides rapid, label-free and objective analysis, particularly important in the field of biomedical analysis. Due to their unique properties, QCLs offer new possibilities for development of analytical methods to enable quantification of clinically relevant concentration levels and to support medical diagnostics...
August 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28814728/prevalence-of-smoking-in-patients-with-bipolar-disorder-major-depressive-disorder-and-schizophrenia-and-their-relationships-with-quality-of-life
#5
Xiao-Hong Li, Feng-Rong An, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Ping-Ping Wu, Xin Jin, Yu-Tao Xiang
Few studies have compared the prevalence of smoking between patients with bipolar disorder, major depressive disorder (MDD) and schizophrenia. This study examined the prevalence of smoking and its relationships with demographic and clinical characteristics, and quality of life (QOL) in patients with these psychiatric disorders. A total of 1,102 inpatients were consecutively screened. Psychopathology and QOL were measured with standardized instruments. The prevalence of current smoking in the whole sample was 16...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28809084/practice-characteristics-and-service-provision-rates-of-dental-hygienists-in-australia
#6
N Amarasena, D N Teusner, D S Brennan, J Satur
INTRODUCTION: Dental hygienists (DHs) have been practising in Australia since the early 1970s. OBJECTIVE: This study describes the clinical activity of Australian DHs. METHODS: A questionnaire was mailed to members of two professional associations representing DHs. Practitioner characteristics, employment characteristics and clinical activity on a self-reported typical practice day were collected. The proportion of each service item of all services provided was estimated...
August 14, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28809010/bioinformatics-resources-for-interpreting-proteomics-mass-spectrometry-data
#7
Iulia M Lazar
Developments in mass spectrometry (MS) instrumentation have supported the advance of a variety of proteomic technologies that have enabled scientists to assess differences between healthy and diseased states. In particular, the ability to identify altered biological processes in a cell has led to the identification of novel drug targets, the development of more effective therapeutic drugs, and the growth of new diagnostic approaches and tools for personalized medicine applications. Nevertheless, large-scale proteomic data generated by modern mass spectrometers are extremely complex and necessitate equally complex bioinformatics tools and computational algorithms for their interpretation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28807864/reducing-diagnostic-turnaround-times-of-exome-sequencing-for-families-requiring-timely-diagnoses
#8
Aurélie Bourchany, Christel Thauvin-Robinet, Daphné Lehalle, Ange-Line Bruel, Alice Masurel-Paulet, Nolwenn Jean, Sophie Nambot, Marjorie Willems, Laetitia Lambert, Salima El Chehadeh-Djebbar, Elise Schaefer, Aurélia Jaquette, Judith St-Onge, Charlotte Poe, Thibaud Jouan, Martin Chevarin, Patrick Callier, Anne-Laure Mosca-Boidron, Nicole Laurent, Mathilde Lefebvre, Frédéric Huet, Nada Houcinat, Sébastien Moutton, Christophe Philippe, Frédéric Tran-Mau-Them, Antonio Vitobello, Paul Kuentz, Yannis Duffourd, Jean-Baptiste Rivière, Julien Thevenon, Laurence Faivre
BACKGROUND AND OBJECTIVE: Whole-exome sequencing (WES) has now entered medical practice with powerful applications in the diagnosis of rare Mendelian disorders. Although the usefulness and cost-effectiveness of WES have been widely demonstrated, it is essential to reduce the diagnostic turnaround time to make WES a first-line procedure. Since 2011, the automation of laboratory procedures and advances in sequencing chemistry have made it possible to carry out diagnostic whole genome sequencing from the blood sample to molecular diagnosis of suspected genetic disorders within 50 h...
August 11, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28805149/contestation-instrumental-resistance-and-strategic-conformation-within-the-diagnostic-process-of-gender-dysphoria-in-portugal
#9
Ana Patrícia Hilário
This article aims to provide insights into the ways in which trans people (i.e. those whose gender identity or expression do not align with their assigned sex at birth) in Portugal make sense of the diagnosis of gender dysphoria. Drawing upon in-depth interviews with 10 trans men and 9 trans women carried out by the TRANSRIGHTS team, we identified three major themes: (a) contestation of gender dysphoria as a (mental) illness, (b) instrumental resistance to complete demedicalisation of gender dysphoria and (c) strategic conformation to gender essentialism within the diagnostic process of gender dysphoria...
September 2017: Health (London)
https://www.readbyqxmd.com/read/28804582/how-do-patients-perceive-and-expect-quality-of-surgery-diagnostics-and-emergency-services-in-tertiary-care-hospitals-an-evidence-of-gap-analysis-from-pakistan
#10
Iram Fatima, Ayesha Humayun, Muhammad Imran Anwar, Adil Iftikhar, Muhammad Aslam, Muhammad Shafiq
OBJECTIVES: Service quality is one of the important gears to appraise services and determine the gray areas that need improvement. In countries with a resource-poor health system, the first step of measuring quality is yet to be taken. This study seeks to inform policy makers in developing contextual service quality models by identifying service quality gaps in tertiary care teaching hospitals using patients' perspective. METHODS: A cross-sectional study was performed using multistage cluster sampling, and a modified version of the SERVQUAL (SERV-service, QUAL-quality) instrument was administered to determine patient's expectations and perceptions...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28803708/anti-phospholipid-syndrome-current-opinion-on-mechanisms-involved-laboratory-characterization-and-diagnostic-aspects
#11
REVIEW
Jean Amiral, Marie Peyrafitte, Claire Dunois, Anne Marie Vissac, Jerard Seghatchian
Anti-phospholipid syndrome is a complex and severe clinical situation, associated with symptoms such as recurrent thrombosis, arterial or venous, at any site, pregnancy loss, and other related syndromes. These clinical burdens, are highly variable from patient to patient, and are associated with biological abnormalities, such as the presence of the Lupus Anticoagulant or phospholipid dependent antibodies, confirmed on two occasions at least 12 weeks apart. From the diagnosis standpoint, both, functional (clotting) or immunological assays, are difficult to standardize and to optimize, due to the absence of reference material, or a characteristic clinical group, and international reference preparations...
July 15, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28801031/substitution-of-doctors-with-physiotherapists-in-the-management-of-common-musculoskeletal-disorders-a-systematic-review
#12
REVIEW
Darryn Marks, Tracy Comans, Leanne Bisset, Paul A Scuffham
BACKGROUND: There is large variation in models-of-care involving the professional substitution of doctors with physiotherapists. OBJECTIVE: To establish the impact upon patients and health services, of substituting doctors with physiotherapists in the management of common musculoskeletal disorders. DATA SOURCES: Medline, CINAHL and ABI Complete databases, and hand-searching of related studies. STUDY SELECTION: Randomised and non-randomised clinical trials, inter-rater reliability and comparative studies comparing the outcomes of usual care from doctors, with outcomes when the doctor was substituted with a physiotherapist...
November 28, 2016: Physiotherapy
https://www.readbyqxmd.com/read/28800308/cancer-stem-cells-as-functional-biomarkers
#13
Vito D'Andrea, Alessandra Panarese, Maya Tonda, Marco Biffoni, Massimo Monti
According to the American Association of Cancer Research (AACR), a Cancer Stem Cell is a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that constitutes the tumor [1]. Cancer Stem Cells (CSCs) are involved in the metastatic process, in the resistance to therapeutic treatments of many types of human cancers and consequently in the onset of recurrences. Numerous translational studies have been conducted to understand CSC characteristics and evaluate association between CSC-related biomarkers and clinical outcomes...
July 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28799407/is-the-assessment-of-personality-comparable-in-persons-who-have-and-have-not-experienced-depressive-anxiety-and-substance-use-disorders-an-examination-of-measurement-invariance
#14
Thomas M Olino, Laura Benini, Grace Icenogle, Sylia Wilson, Daniel N Klein, John R Seeley, Peter M Lewinsohn
Numerous studies have focused on characterizing personality differences between individuals with and without psychopathology. For drawing valid conclusions for these comparisons, the personality instruments used must demonstrate psychometric equivalence. However, we are unaware of any studies that examine measurement invariance in personality across individuals with and without psychopathology. This study conducted tests of measurement invariance for positive emotionality, negative emotionality, and disinhibition across individuals with and without histories of depressive, anxiety, and substance use disorders...
August 1, 2017: Assessment
https://www.readbyqxmd.com/read/28796805/pain-experiences-of-patients-with-musculoskeletal-pain-central-sensitization-a-comparative-group-delphi-study
#15
Axel Georg Meender Schäfer, Leonie Johanna Joos, Katharina Roggemann, Kerstin Waldvogel-Röcker, Michael Pfingsten, Frank Petzke
OBJECTIVES: Central sensitization (CS) is regarded as an important contributing factor for chronification of musculoskeletal pain (MSP). It is crucial to identify CS, as targeted multimodal treatment may be indicated. The primary objective of this study was therefore to explore pain experience of individuals with MSP+CS in order to gain a better understanding of symptoms in relation to CS from a patient perspective. The secondary objective was to investigate whether pain experiences of patients with MSP+CS differ from those of individuals with neuropathic pain (NP)...
2017: PloS One
https://www.readbyqxmd.com/read/28795247/german-translation-cross-cultural-adaptation-and-diagnostic-test-accuracy-of-three-frailty-screening-tools-prisma-7-frail-scale-and-groningen-frailty-indicator
#16
Tobias Braun, Christian Grüneberg, Christian Thiel
BACKGROUND: Routine screening for frailty could be used to timely identify older people with increased vulnerability und corresponding medical needs. OBJECTIVE: The aim of this study was the translation and cross-cultural adaptation of the PRISMA-7 questionnaire, the FRAIL scale and the Groningen Frailty Indicator (GFI) into the German language as well as a preliminary analysis of the diagnostic test accuracy of these instruments used to screen for frailty. METHODS: A diagnostic cross-sectional study was performed...
August 9, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28794619/grip-strength-as-a-frailty-diagnostic-component-in-geriatric-inpatients
#17
Joanna Dudzińska-Griszek, Karolina Szuster, Jan Szewieczek
BACKGROUND: Frailty has emerged as a key medical syndrome predictive of comorbidity, disability, institutionalization and death. As a component of the five frailty phenotype diagnostic criteria, patient grip strength deserves attention as a simple and objective measure of the frailty syndrome. The aim of this study was to assess conditions that influence grip strength in geriatric inpatients. PATIENTS AND METHODS: The study group consisted of 80 patients aged 78...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28793892/utility-of-the-phq-9-to-identify-major-depressive-disorder-in-adult-patients-in-spanish-primary-care-centres
#18
Roger Muñoz-Navarro, Antonio Cano-Vindel, Leonardo Adrián Medrano, Florian Schmitz, Paloma Ruiz-Rodríguez, Carmen Abellán-Maeso, Maria Antonia Font-Payeras, Ana María Hermosilla-Pasamar
BACKGROUND: The prevalence of major depressive disorder (MDD) in Spanish primary care (PC) centres is high. However, MDD is frequently underdiagnosed and consequently only some patients receive the appropriate treatment. The present study aims to determine the utility of the Patient Health Questionnaire-9 (PHQ-9) to identify MDD in a subset of PC patients participating in the large PsicAP study. METHODS: A total of 178 patients completed the full PHQ test, including the depression module (PHQ-9)...
August 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28777178/sleep-disordered-breathing
#19
Nancy R Foldvary-Schaefer, Tina E Waters
PURPOSE OF REVIEW: Sleep-disordered breathing encompasses a broad spectrum of sleep-related breathing disorders, including obstructive sleep apnea (OSA), central sleep apnea, as well as sleep-related hypoventilation and hypoxemia. Diagnostic criteria have been updated in the International Classification of Sleep Disorders, Third Edition and the American Academy of Sleep Medicine Manual for Scoring Sleep and Associated Events. Neurologic providers should have basic knowledge and skills to identify at-risk patients, as these disorders are associated with substantial morbidity, the treatment of which is largely reversible...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28777134/retrospective-analysis-of-transcranial-doppler-patterns-in-veno-arterial-extracorporeal-membrane-oxygenation-patients-feasibility-of-cerebral-circulatory-arrest-diagnosis
#20
Marinella Marinoni, Giovanni Cianchi, Sara Trapani, Maria L Migliaccio, Manuela Bonizzoli, Letizia Gucci, Antonella Cramaro, Andrea Gallerini, Fabio Picciafuochi, Serafina Valente, Adriano Peris
Transcranial Doppler (TCD) is able to detect cerebral hemodynamic changes in real-time. Impairment of cerebral blood flow during veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) treatment is referred to in the literature. Several cerebrovascular complications can affect VA ECMO patients, eventually leading to brain death (BD). Transcranial Doppler is a worldwide accepted technique for cerebral circulatory arrest (CCA) diagnosis for BD confirmation, and in Italy, it is mandatory in certain clinical conditions...
August 1, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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