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Delta frame

Gregory I Peterson, Johanna J Schwartz, Di Zhang, Benjamin M Weiss, Mark A Ganter, Duane W Storti, Andrew J Boydston
We describe an efficient method to produce objects comprising spatially controlled and graded cross-link densities using vat photopolymerization additive manufacturing (AM). Using a commercially available diacrylate-based photoresin, 3D printer, and digital light processing (DLP) projector, we projected grayscale images to print objects in which the varied light intensity was correlated to controlled cross-link densities and associated mechanical properties. Cylinder and bar test specimens were used to establish correlations between light intensities used for printing and cross-link density in the resulting specimens...
October 11, 2016: ACS Applied Materials & Interfaces
Emma Beasley, Simona Francese, Tom Bassindale
The sample preparation method reported in this work has permitted for the first time the application of matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) profiling and imaging for the detection and mapping of cannabinoids in a single hair sample. MALDI-MS imaging analysis of hair samples has recently been suggested as an alternative technique to traditional methods of GC/MS and LC/MS due to simpler sample preparation, the ability to detect a narrower time frame of drug use, and a reduction in sample amount required...
October 18, 2016: Analytical Chemistry
Giovanna Tassoni, Marta Cippitelli, Dora Mirtella, Rino Froldi, Giovanni Ottaviani, Massimiliano Zampi, Mariano Cingolani
Under Italian law drug addiction and regular drug abuse are incompatible with driving ability. One important problem with the enforcement of the impaired driving law is the large number of people that re-offend. To regain their license, offenders must be drug-free for the duration of an observation period, according to the judgement of a medical commission. The exclusion of illicit drug use is determined by toxicological analysis. A few studies exist that have used a hair matrix to monitor recidivism. Hair is an attractive matrix for monitoring drug recidivism, due to the large time window for drug detection, and to the non-alterability of this matrix...
October 2016: Forensic Science International
Pietro Caliandro, Fabrizio Vecchio, Francesca Miraglia, Giuseppe Reale, Giacomo Della Marca, Giuseppe La Torre, Giordano Lacidogna, Chiara Iacovelli, Luca Padua, Placido Bramanti, Paolo Maria Rossini
Background After cerebral ischemia, disruption and subsequent reorganization of functional connections occur both locally and remote to the lesion. Recently, complexity of brain connectivity has been described using graph theory, a mathematical approach that depicts important properties of complex systems by quantifying topologies of network representations. Functional and dynamic changes of brain connectivity can be reliably analyzed via electroencephalography (EEG) recordings even when they are not yet reflected in structural changes of connections...
January 2017: Neurorehabilitation and Neural Repair
Dirk Wildemeersch, Norman D Goldstuck, Thomas Hasskamp
Immediate postpartum intrauterine device (IUD) insertion deserves great attention as it can provide immediate, timely and convenient contraception plus the added benefit of preventing repeat unintended pregnancies. Although women post vaginal delivery can benefit from immediate post-placenta contraception, women undergoing Cesarean section clearly need contraception, as an inter-delivery interval shorter than 18 months places them at a high risk for uterine rupture. The main drawback of currently available framed IUD devices for immediate postpartum insertion of an IUD is their high expulsion and displacement rates when inserted immediately postpartum after both vaginal and Cesarean delivery...
January 2016: Developmental Period Medicine
Jiangtao Hu, Wei Zhao, Siyuan Zhan, Ping Xiao, Jingxuan Zhou, Linjie Wang, Li Li, Hongping Zhang, Lili Niu, Tao Zhong
To research the molecular characteristics, expression pattern and phylogeny of the Delta-like 1 homolog gene (Dlk1) in goats. Dlk1 transcripts were identified in the Jianyang Da'er goats by reverse-transcription polymerase chain reaction (RT-PCR). Phylogenetic trees were constructed by Bayesian inference and neighbor-joining methods. Quantitative real-time PCR (qPCR), western blotting and in situ hybridization were performed to analyze the expression pattern of Dlk1. Five alternatively transcripts were identified in different tissues and designated as Dlk1-AS1, 2, 3, 4 and 5...
June 2016: Molecular Biology Reports
Guy Cheron, Géraldine Petit, Julian Cheron, Axelle Leroy, Anita Cebolla, Carlos Cevallos, Mathieu Petieau, Thomas Hoellinger, David Zarka, Anne-Marie Clarinval, Bernard Dan
Brain dynamics is at the basis of top performance accomplishment in sports. The search for neural biomarkers of performance remains a challenge in movement science and sport psychology. The non-invasive nature of high-density electroencephalography (EEG) recording has made it a most promising avenue for providing quantitative feedback to practitioners and coaches. Here, we review the current relevance of the main types of EEG oscillations in order to trace a perspective for future practical applications of EEG and event-related potentials (ERP) in sport...
2016: Frontiers in Psychology
Judy Peat, Brehon Davis, Clint Frazee, Uttam Garg
Maternal substance abuse is an ongoing concern and detecting drug use during pregnancy is an important component of neonatal care when drug abuse is suspected. Meconium is the preferred specimen for drug testing because it is easier to collect than neonatal urine and it provides a much broader time frame of drug exposure. We describe a method for quantifying 11-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in meconium. After adding a labeled internal standard (THC-COOH D9) and acetonitrile, samples are sonicated to release both free and conjugated THC-COOH...
2016: Methods in Molecular Biology
Jing Ran, Dejian Wang, Can Wang, Gang Zhang, Hailin Zhang
The entry of heavy metals into the food chain is of concern for potential health risks. To investigate the spatial relationships of heavy metals in a regional soil-wheat system, 99 pairs of surface soil (0-15 cm) and wheat grain samples were collected from Changshu, China, a typical county in the Yangtze Delta region. Both soil and wheat grain samples were analyzed for total Cd, Cu, Ni, Pb, and Zn. DTPA-extractable metals and major physico-chemical properties were also determined for soil samples. Moderate accumulation of heavy metals was found in soils and wheat grains, especially Cd...
February 15, 2016: Science of the Total Environment
Celso Cunha, João Paulo Tavanez, Severin Gudima
Hepatitis delta virus (HDV) is the etiologic agent of the most severe form of virus hepatitis in humans. Sharing some structural and functional properties with plant viroids, the HDV RNA contains a single open reading frame coding for the only virus protein, the Delta antigen. A number of unique features, including ribozyme activity, RNA editing, rolling-circle RNA replication, and redirection for a RNA template of host DNA-dependent RNA polymerase II, make this small pathogen an excellent model to study virus-cell interactions and RNA biology...
November 12, 2015: World Journal of Virology
Julie L Calahan, Stephanie C Azali, Eric J Munson, Karthik Nagapudi
Intimate phase mixing between the drug and the polymer is considered a prerequisite to achieve good physical stability for amorphous solid dispersions. In this article, spray dried amorphous dispersions (ASDs) of AMG 517 and HPMC-as were studied by differential scanning calorimetry (DSC), solid-state NMR (SSNMR), and solution calorimetry. DSC analysis showed a weakly asymmetric (ΔTg ≈ 13.5) system with a single glass transition for blends of different compositions indicating phase mixing. The Tg-composition data was modeled using the BKCV equation to accommodate the observed negative deviation from ideality...
November 2, 2015: Molecular Pharmaceutics
Meng Xu, Zhan Ma, Yao Wang
This paper presents a novel low-complexity motion estimation and mode decision algorithm for encoding multiple quality layers following the H.264/scalable video coding standard, considering both coarse grain scalability (CGS) and medium grain scalability (MGS). The proposed algorithm conducts motion estimation and mode decision only at the base layer (BL) and enforces the higher layers to inherit the motion and mode decisions of the BL. In order for the decision made at the BL to be nearly optimal for all layers, we use the highest layer reconstructed frame as the reference frame for motion estimation and set the Lagrangian multipliers according to the quantization parameter of the current and higher layers...
November 2015: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
A P Baltensperger, F Huettmann
Climate change is acting to reallocate biomes, shift the distribution of species, and alter community assemblages in Alaska. Predictions regarding how these changes will affect the biodiversity and interspecific relationships of small mammals are necessary to pro-actively inform conservation planning. We used a set of online occurrence records and machine learning methods to create bioclimatic envelope models for 17 species of small mammals (rodents and shrews) across Alaska. Models formed the basis for sets of species-specific distribution maps for 2010 and were projected forward using the IPCC (Intergovernmental Panel on Climate Change) A2 scenario to predict distributions of the same species for 2100...
2015: PloS One
Mohan V Belthur, Christopher A Iobst, Noam Bor, Eitan Segev, Mark Eidelman, Shawn C Standard, John E Herzenberg
BACKGROUND: Cubitus varus is a well-reported complication of supracondylar fracture of the humerus potentially resulting in cosmetic problems, impaired function, and malpractice claims. Traditional methods of correcting malunited distal humeral fractures involve complex osteotomies that have a high complication rate, require a large exposure, and challenging fixation. We present a technique of gradual correction using a percutaneous transverse osteotomy and 3 dimensional correction with a Taylor Spatial Frame...
September 2016: Journal of Pediatric Orthopedics
Mark F Bird, David G Lambert
PURPOSE OF REVIEW: This article aims to discuss the multitarget concept for opioid receptor ligands framed on early observations that activating MOP (mu:μ) receptor whilst simultaneously blocking DOP (delta:δ) receptors reduces the onset of morphine tolerance. The review period is ostensibly calendar year 2014 but the new work in 2013 is also covered. RECENT FINDINGS: Two molecules of interest with MOP agonist/DOP agonist and MOP agonist/DOP antagonist profiles were described: Rv-Jim-C3 and 3-[(2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide (LP1), respectively...
June 2015: Current Opinion in Supportive and Palliative Care
Francisco Vázquez-Gallego, Luis Alonso, Jesus Alonso-Zarate
Reservation frame slotted-ALOHA (RFSA) was proposed in the past to manage the access to the wireless channel when devices generate long messages fragmented into small packets. In this paper, we consider an M2M area network composed of end-devices that periodically respond to the requests from a gateway with the transmission of fragmented messages. The idle network is suddenly set into saturation, having all end-devices attempting to get access to the channel simultaneously. This has been referred to as delta traffic...
2015: Sensors
Chi-Ruei Huang, Szecheng John Lo
Viral hepatitis remains a worldwide public health problem. The hepatitis D virus (HDV) must either coinfect or superinfect with the hepatitis B virus (HBV). HDV contains a small RNA genome (approximately 1.7 kb) with a single open reading frame (ORF) and requires HBV supplying surface antigens (HBsAgs) to assemble a new HDV virion. During HDV replication, two isoforms of a delta antigen, a small delta antigen (SDAg) and a large delta antigen (LDAg), are produced from the same ORF of the HDV genome. The SDAg is required for HDV replication, whereas the interaction of LDAg with HBsAgs is crucial for packaging of HDV RNA...
October 28, 2014: World Journal of Gastroenterology: WJG
Mingbo Gong, Chaoxi Tang, Changxiong Zhu
A primary cDNA library of Penicillium oxalicum I1 was constructed using the switching mechanism at the 5' end of the RNA transcript (SMART) technique. A total of 106 clones showed halos in tricalcium phosphate (TCP) medium, and clone I-40 showed clear halos. The full-length cDNA of clone I-40 was 1355 bp with a complete open reading frame (ORF) of 1032 bp, encoding a protein of 343 amino acids. Multiple alignment analysis revealed a high degree of homology between the ORF of clone I-40 and delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH) of other fungi...
November 2014: Canadian Journal of Microbiology
Samuel W Lukowski, Joseph A Rothnagel, Ann E O Trezise
Post-transcriptional regulation of gene expression through 5' untranslated region (5'UTR)-encoded cis-acting elements is an important mechanism for the control of protein expression levels. Through controlling specific aspects of translation initiation, expression can be tightly regulated while remaining responsive to cellular requirements. With respect to cystic fibrosis (CF), the overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) protein trafficking mutants, such as delta-F508, is of great biological and clinical interest...
February 15, 2015: Human Molecular Genetics
He Lu, Yu Zhu
This research aims at isolating and identifying γ-linolenic acid (GLA)-producing fungi in the traditional Chinese salt-fermented soybean food, Douchi, from Yongchuan, People's Republic of China. In this study, Rhizopus oryzae DR3 was identified as a novel fungal species that produces large amounts of GLA. A full-length cDNA, designated as RoD6 D, with high homology to fungal △6 fatty acid desaturase genes was isolated from R. oryzae by using the rapid amplification of cDNA ends method. It had an open reading frame of 1,176 bp encoding a deduced polypeptide of 391 amino acids...
May 2015: Biotechnology and Applied Biochemistry
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