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https://www.readbyqxmd.com/read/27904276/late-onset-complication-of-fillers-paraffinoma-of-the-lower-eyelids-clinically-mimicking-xanthelasma
#1
Min-Woo Kim, Hyun-Sun Park, Hyun-Sun Yoon, Soyun Cho
Injectable poly-L-lactic acid (PLLA) is world-famous filler used in lipoatrophy and facial rejuvenation because of its collagen neogenesis effect which leads to gradual volume restoration. Until recently, quite a number of unwanted adverse events of PLLA have been reported. However, to the best of our knowledge, paraffinoma as a complication of PLLA has never been reported. We herein describe the first case of paraffinoma after Sculptra® injection and propose its possible mechanism.
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27886655/gas-permeability-and-permselectivity-of-poly-l-lactic-acid-siox-film-and-its-application-in-equilibrium-modified-atmosphere-packaging-for-chilled-meat
#2
Tungalag Dong, Shuxin Song, Min Liang, Yu Wang, Xiaojing Qi, Yuqin Zhang, Xueyan Yun, Ye Jin
A layer of SiOx was deposited on the surface of poly(L-lactic acid) (PLLA) film to fabricate a PLLA/SiOx layered film, by plasma-enhanced chemical vapor deposition (PECVD) process. PLLA/SiOx film showed Young's modulus and tensile strength increased by 119.2% and 91.6%, respectively, over those of neat PLLA film. At 5 °C, the oxygen (O2 ) and carbon dioxide (CO2 ) permeability of PLLA/SiOx film decreased by 78.7% and 71.7%, respectively, and the CO2 /O2 permselectivity increased by 32.5%, compared to that of the neat PLLA film...
November 25, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27885997/the-enhancement-of-osteogenic-capacity-in-a%C3%A2-synthetic-bmp-2-derived-peptide-coated-mineralized-collagen-composite-in-the-treatment-of-the-mandibular-defects
#3
Lei Zhang, Weidong Mu, Shuangfeng Chen, Dawei Yang, Fei Xu, Yaping Wu
The novel synthetic peptide P17-BMP-2 could promote cell attachment and enhance osteogenic capability. A composite, comprising nano-hydroxyapatite, collagen and poly(L-lactide) (nHAC/PLLA), was an efficient scaffold for carrier of P17-BMP-2. Our aim was to investigate whether nHAC/PLLA/P17-BMP-2 accelerates the osteogenesis as a reliable method for mandibular defect healing in this study. The repair capability was assessed by the gross observation, X-ray test and histological observation in four animal experiment groups at 2 week and 4 week after surgery: Group A (control), Group B (nHAC/PLLA treatment), Group C (nHAC/PLLA with 2 mg/g P17-BMP-2 treatment) and Group D (nHAC/PLLA with 10 mg/g P17-BMP-2 treatment)...
November 25, 2016: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27875036/drug-loaded-nanoparticle-coating-on-totally-bioresorbable-plla-stents-to-prevent-in-stent-restenosis
#4
Jian Zhao, Zhichao Mo, Fangfang Guo, Donglu Shi, Qian Qian Han, Qing Liu
Biodegradable polymer poly (dl-lactide) (PDLLA) has been used as drug coating material for drug-eluting stents due to its excellent biocompatibility and sustained drug release ability. However, the uniform thin layer drug eluting coating on a stent not only inhibits the blood vessel's smooth muscle cell overgrowth but also delay the endotheliation process which is often associated with the occurrence of acute thrombosis. Therefore, in this study, we developed a novel coating method using PDLLA nanoparticles (NPs) as a coating to overcome this issue...
November 22, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27871052/crystallinity-as-a-tunable-switch-of-poly-l-lactide-shape-memory-effects
#5
Michał Sobota, Sebastian Jurczyk, Michał Kwiecień, Anna Smola-Dmochowska, Marta Musioł, Marian Domański, Henryk Janeczek, Michał Kawalec, Piotr Kurcok
Materials with shape memory effect (SME) have already been widely used in the medical field. The interesting part of this group is represented by double function materials. The bioresorption and SME ability are common in polyesters implants. The first information about vascular stent made of bioresorbable polyester with SME was published in 2000. However, there are not many investigations about SME control of elements in the aspect of material processing. In the present work, the ability to control the shape memory (SM) of bioresorbable and semicrystalline poly(L-lactide) (PLLA) is investigated...
November 12, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27819188/feasibility-of-3-d-bioprinting-with-a-modified-desktop-3d-desktop-printer
#6
Todd Goldstein, Lee P Smith, Alex Krush, Kevin Mercadante, Dan Lagalante, Casey Epstein, John A Schwartz, David Zeltsman, Daniel Anthony Grande
Numerous studies have shown the capabilities of 3D printing for use in the medical industry. At the time of this publication, basic home desktop 3-D printer kits can cost as little as $300, while medical-specific 3D bioprinters can cost upwards of $300,000. The purpose of this study was to show how a commercially available desktop 3D printer could be modified to bioprint an engineered poly-L-lactic acid (PLLA) scaffold containing viable chondrocytes in a bioink. Our bioprinter was used to create a living 3D functional tissue-engineered cartilage scaffold...
November 7, 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27816621/degradation-intra-articular-retention-and-biocompatibility-of-monospheres-composed-of-pdlla-peg-pdlla-b-plla-multi-block-copolymers
#7
Maria J Sandker, Luisa F Duque, Everaldo M Redout, Alan Chan, Ivo Que, Clemens W G M Löwik, Evelien C Klijnstra, Nicole Kops, Rob Steendam, Rene van Weeren, Wim E Hennink, Harrie Weinans
In this study, we investigated the use of microspheres with a narrow particle size distribution ('monospheres') composed of biodegradable poly(DL-lactide)-PEG-poly(DL-lactide)-b-poly(L-lactide) multiblock copolymers that are potentially suitable for local sustained drug release in articular joints. Monospheres with sizes of 5, 15 and 30 μm and a narrow particle size distribution were prepared by a micro-sieve membrane emulsification process. During in vitro degradation, less crystallinity, higher swelling and accelerated mass loss during was observed with increasing the PEG content of the polymer...
November 2, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27815574/evaluation-of-a-bioabsorbable-self-expandable-vein-stent-base-made-of-poly-l-lactide-in-vitro-and-in-vivo
#8
Alexandra Liv Vest Løvdal, Sarah Calve, Shuo Yang, William Van Alstine, Christoph A Binkert, Kasper Klausen
PURPOSE: This study was designed to evaluate performance and tissue response to a self-expandable bioabsorbable vein stent-base cut from a tube with enhanced stiffness and strength in vitro and in vivo. METHODS: A diamond-shaped stent-base was cut from a sequential biaxially strained poly(L-lactide) (PLLA) tube for optimized performance. The performance of the stent-base was evaluated in a finite element analysis model, and validation was attempted in vitro through a cyclic flat-plate compression and radial force measurement...
November 4, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27805775/magnetically-controlled-drug-release-system-through-magnetomechanical-actuation
#9
João Barbosa, Daniela Maria Correia, Renato Gonçalves, Clarisse Ribeiro, Gabriela Botelho, Pedro Martins, Senentxu Lanceros-Mendez
A drug release system is developed capable to modulate the drug release kinetics by the application of a magnetic field. Thus, this work reports on the production, characterization, and release kinetics of a poly(l-lactic acid) (PLLA) microporous membrane containing a zeolite (Faujasite) and a magnetic stimuli-sensitive component, magnetostrictive Terfenol-D (TD), for the release of ibuprofen (IBU) as drug model. For membranes containing IBU-loaded zeolites and TD without an applied AC magnetic field, the release kinetics is characterized by a first order release...
November 2, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27801593/elucidation-of-chiral-symmetry-breaking-in-a-racemic-polymer-system-with-terahertz-vibrational-spectroscopy-and-crystal-orbital-density-functional-theory
#10
Feng Zhang, Houng-Wei Wang, Keisuke Tominaga, Michitoshi Hayashi, Sunglin Lee, Takashi Nishino
The conservation of chiral symmetry has been used as a fundamental rule to determine polymer packing-conformations in racemic systems. We have illustrated, through the interplay of polarization THz spectroscopy and solid-state density functional theory, that the chiral symmetry is not conserved in a poly(lactic acid) stereocomplex (scPLA) system. poly(L-lactic acid) (PLLA) displays a weaker violation of the 31 screw symmetry than poly(D-lactic acid) (PDLA), and possesses a stronger intramolecular vibrational energy, on average, in the low-frequency gamma-point phonon modes than does PDLA...
November 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27776320/assessment-of-mechanical-behavior-of-pla-composites-reinforced-with-mg-micro-particles-through-depth-sensing-indentations-analysis
#11
S C Cifuentes, E Frutos, R Benavente, V Lorenzo, J L González-Carrasco
This work deals with the mechanical characterization by depth-sensing indentation (DSI) of PLLA and PLDA composites reinforced with micro-particles of Mg (up to 15wt%), which is a challenging task since the indented volume must provide information of the bulk composite, i.e. contain enough reinforcement particles. The composites were fabricated by combining hot extrusion and compression moulding. Physico-chemical characterization by TGA and DSC indicates that Mg anticipates the thermal degradation of the polymers but does not compromise their stability during processing...
September 21, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27775924/poly-l-lactic-acid-scaffold-with-oriented-micro-valley-surface-and-superior-properties-fabricated-by-solid-state-drawing-for-blood-contact-biomaterials
#12
Seung Hyuk Im, Youngmee Jung, Yangsoo Jang, Soo Hyun Kim
Most biomaterials composed of biodegradable polymers will contact either accidentally or consistently with blood and this commonly requires both good  mechanical strength and blood compatibility. Despite this demand, current processing methods still make it difficult and complex to simultaneously improve the two properties. To overcome present limitations, the aim of this work is to develop a solid-state drawing which is a novel method for blood-contact biomaterials that can simultaneously improve the two essential factors of mechanical strength and blood compatibility, as well as induce a micro-patterned surface...
October 24, 2016: Biofabrication
https://www.readbyqxmd.com/read/27774684/pcl-plla-semi-ipn-shape-memory-polymers-smps-degradation-and-mechanical-properties
#13
Lindsay N Woodard, Vanessa M Page, Kevin T Kmetz, Melissa A Grunlan
Thermoresponsive shape memory polymers (SMPs) based on poly(ε-caprolactone) (PCL) whose shape may be actuated by a transition temperature (T trans ) have shown utility for a variety of biomedical applications. Important to their utility is the ability to modulate mechanical and degradation properties. Thus, in this work, SMPs are formed as semi-interpenetrating networks (semi-IPNs) comprised of a cross-linked PCL diacrylate (PCL-DA) network and thermoplastic poly(l-lactic acid) (PLLA). The semi-IPN uniquely allows for requisite crystallization of both PCL and PLLA...
December 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27770955/intermolecular-interactions-between-b-mori-silk-fibroin-and-poly-l-lactic-acid-in-electrospun-composite-nanofibrous-scaffolds
#14
Paola Taddei, Silvia Tozzi, Giampaolo Zuccheri, Simona Martinotti, Elia Ranzato, Valeria Chiono, Irene Carmagnola, Masuhiro Tsukada
In this study, composite nanofibrous scaffolds were obtained by electrospinning a trifluoroacetic acid solution containing B. mori silk fibroin (SF) and poly(l-lactic acid) (PLLA) in a 1:1 weight ratio. SF, PLLA and SF/PLLA nanofibres were prepared with average diameter sizes of 360±90nm, 470±240nm and 580±220nm, respectively, as assessed by SEM analysis. Vibrational and thermal analyses showed that upon blending in the SF/PLLA nanofibres, the crystallisation of PLLA was hindered by the presence of SF, which crystallized preferentially and underwent conformational changes that did not significantly change its prevailing β-sheet structure...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770908/factors-influencing-the-stability-and-type-of-hydroxyapatite-stabilized-pickering-emulsion
#15
Ming Zhang, Ai-Juan Wang, Jun-Ming Li, Na Song, Yang Song, Rui He
Hydroxyapatite (HAp) nanoparticle stabilized Pickering emulsion was fabricated with poly(l-lactic acid) dissolved in dichloromethane (CH2Cl2) solution as oil phase and HAp aqueous dispersion as aqueous phase. Pickering emulsion was cured via in situ solvent evaporation method. Effect of PLLA concentrations, pH value, HAp concentrations, oil-water ratio, emulsification rates and times were studied on emulsion stability and emulsion type, etc. The results indicated emulsion stability increased with the increase of HAp concentration, emulsification rate and time; it is very stable when pH value of aqueous phase was adjusted to 10...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27768911/enhancement-of-neurite-adhesion-alignment-and-elongation-on-conductive-polypyrrole-poly-lactide-acid-fibers-with-cell-derived-extracellular-matrix
#16
Xingxing Zhou, Anneng Yang, Zhongbing Huang, Guangfu Yin, Ximing Pu, Juan Jin
Extracellular matrix (ECM) can promote peripheral nerve repair. In this study, a conductive fiber-film (CFF) with core-sheath structure and conductivity of ∼10Scm(-1) was prepared by electrospinning of aligned poly(l-lactide acid) (PLLA) fibers and electrochemical deposition of polypyrole (PPy) nanoparticles. Then the multiple components of ECM, including laminin, fibronectin and collagen, were coated on the surface of CFF by culturing and lysing L929 cells to fabricate the bioactive scaffold of ECM-linked CFF (ECM-CFF)...
October 11, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27766219/osteogenic-odontogenic-bioengineering-with-co-administration-of-simvastatin-and-hydroxyapatite-on-poly-caprolactone-based-nanofibrous-scaffold
#17
Mohammad Samiei, Marziyeh Aghazadeh, Effat Alizadeh, Naser Aslaminabadi, Soodabeh Davaran, Sajjad Shirazi, Farhad Ashrafi, Roya Salehi
Purpose: Statin is an effective factor for promoting osteogenesis. The aim of the present study was to evaluate the effect of simvastatin (SIM) and/or HA addition on changes in osteogenesis levels by human DPSCs transferred onto three-dimensional (3D) nanofibrous Poly (ε-caprolactone) (PCL)/Poly lactic acide (PLLA) polymeric scaffolds. Methods: For this purpose, a 3D nanofibrous composite scaffold of PCL/PLLA/HA was prepared by electrospinning method. SIM was added to scaffolds during DPSCs culturing step...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27762547/impact-of-collagen-heparin-multi-layers-for-regulating-bone-cellular-functions
#18
Ana Marina Ferreira, Piergiorgio Gentile, Sotiria Toumpaniari, Gianluca Ciardelli, Mark A Birch
Bone cell interaction with extracellular matrix (ECM) microenvironment is of critical importance when engineering surface interfaces for bone regeneration. In this work layer-by-layer films of type I collagen (coll), the major constituent of bone ECM, and heparin (hep), a glycosaminoglycan, were assembled on poly(L-lactide acid) (PLLA) substrates to evaluate the impact of the biomacromolecular coating on cell activity. The surface modification of PLLA demonstrated that the hep/coll multi-layer is stable after 10 bilayers (confirmed by contact angle, infrared spectroscopy and morphological analysis)...
October 20, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27747708/continuous-intra-sinus-bone-regeneration-after-nongrafted-sinus-lift-with-a-plla-mesh-plate-device-and-dental-implant-placement-in-an-atrophic-posterior-maxilla-a-case-report
#19
Takahiro Kaneko, Satoshi Nakamura, Shunsuke Hino, Norio Horie, Tetsuo Shimoyama
BACKGROUND: Sinus lift is a bone augmentation procedure that improves the alveolar crest height in an atrophic posterior maxilla. However, the regenerated bone volume can vary and generally has a tendency to decrease after sinus operation. This article describes nongrafted maxillary sinus lift using a bioresorbable unsintered hydroxyapatite combined with poly L-lactide (HA/PLLA) mesh plate device and dental implant placement in an atrophic posterior maxilla, after which continuous bone gain was observed around the implant apex during a postoperative follow-up period of 3 years...
December 2016: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/27737353/immunohistochemical-expression-of-tgf-%C3%AE-1-and-osteonectin-in-engineered-and-ca-oh-2-repaired-human-pulp-tissues
#20
Luiz Alexandre Chisini, Marcus Cristian Muniz Conde, Jose Carlos Bernedo Alcázar, Adriana Fernandes da Silva, Jacques Eduardo Nör, Sandra Beatriz Chaves Tarquinio, Flávio Fernando Demarco
The aim of the present study was to evaluate the expression of transforming growth factor-β1 (TGF-β1) and osteonectin (ON) in pulp-like tissues developed by tissue engineering and to compare it with the expression of these proteins in pulps treated with Ca(OH)2 therapy. Tooth slices were obtained from non-carious human third molars under sterile procedures. The residual periodontal and pulp soft tissues were removed. Empty pulp spaces of the tooth slice were filled with sodium chloride particles (250-425 µm)...
October 10, 2016: Brazilian Oral Research
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