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https://www.readbyqxmd.com/read/29687699/merging-the-properties-of-a-sirolimus-coated-balloon-with-those-of-a-bioresorbable-polymer-sirolimus-eluting-stent-to-address-the-diabetes-issue-results-from-the-en-abl-multicenter-registry
#1
Luca Testa, Sameer Dani, Devang Desai, Rashmit Pandya, Pritesh Parekh, Nirav Bhalani, Arvind Sharma, Chirag Seth, Manish Doshi, Prakash Sojitra, Poonam Chodvadiya, Gopee Dutta, Francesco Bedogni
BACKGROUND: Patients with diabetes mellitus (DM) have poorer outcomes after percutaneous coronary intervention than patients without diabetes. The Abluminus DES+TM drug-eluting stent (DES) features a novel technology of fusion coating of PLLA bioresorbable polymer on both the abluminal surface of the stent and exposed parts of the balloon. AIM: To evaluate the efficacy/safety profile of the Abluminus DES+ in an all-comers population with minimal exclusion criteria and with a specific focus on diabetic patients...
April 20, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29684675/fak-and-yap-taz-dependent-mechanotransduction-pathways-are-required-for-enhanced-immunomodulatory-properties-of-adipose-derived-mesenchymal-stem-cells-induced-by-aligned-fibrous-scaffolds
#2
S Wan, X Fu, Y Ji, M Li, X Shi, Y Wang
Adipose-derived mesenchymal stem cells (ASCs) represent an excellent candidate for tissue engineering due to their multipotency and paracrine functions. Physical cues provided by the scaffolds have been shown to direct a variety of cellular behaviors of ASCs; however, their effects on the paracrine functions of ASCs, especially immunomodulatory functions, remain largely unexplored. Thus, PLLA electrospun fibrous scaffolds, with fibers oriented either randomly or aligned, were used as a model to investigate the effects of fiber orientation on the immunomodulatory paracrine secretion of ASCs...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29675859/fabrication-of-superparamagnetic-nanofibrous-poly-l-lactic-acid-%C3%AE-fe-2-o-3-microspheres-for-cell-carriers
#3
Moyuan Qu, Wenqian Xiao, Jiarong Tian, Song Wang, Hong Li, Xue Liu, Xiaoling Yang, Bo Li, Xiaoling Liao
Nanofibrous poly(l-lactic acid) (PLLA) microspheres are extensively studied to be used as cell carriers in the field of tissue engineering because the unique structure can promote cell proliferation and migration. But as injectable scaffold materials, PLLA microspheres easily run off to the soft tissue space because of the lack of cohesive force. It will affect the treatment efficiency and even cause additional inflammatory response. In order to overcome this disadvantage, superparamagnetic γ-Fe2 O3 nanoparticles assisted with oxidative polymerization of dopamine were used for surface modification of PLLA microspheres in this study...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29665211/block-stereoblock-copolymers-of-poly-%C3%AE%C2%B5-caprolactone-and-poly-lactic-acid
#4
Tomer Rosen, Israel Goldberg, Wanda Navarra, Vincenzo Venditto, Moshe Kol
A magnesium complex of the type {ONNN}Mg-HMDS wherein {ONNN} is a sequential tetradentate monoanionic ligand is introduced. In the presence of an alcohol initiator this complex catalyzes the living and immortal homopolymerization of the lactide enantiomers and ε-caprolactone at room-temperature with exceptionally high activities, as well as the precise block copolymerization of these monomers in a one-pot synthesis by sequential monomer addition. Copolymers of unprecedented microstructures such as the PCL-b-PLLA-b-PDLA and PDLA-b-PLLA-b-PCL-b-PLLA-b-PDLA block-stereoblock microstructures that feature unique thermal properties are readily accessed...
April 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29644706/preparation-and-evaluation-of-188-re-sulfide-colloidal-nanoparticles-loaded-biodegradable-poly-l-lactic-acid-microspheres-for-radioembolization-therapy
#5
Mina Jamre, Mojtaba Shamsaei, Mostafa Erfani, Sodeh Sadjadi, Mohammad Ghannadi Maragheh
Radioembolization with radioactive microspheres has been an effective method for the treatment of liver lesions. The aim of this study was to prepare carrier-free 188 Re loaded poly (L-lactic acid) (PLLA) microspheres through 188 Re sulfide colloidal nanoparticles (188 Re-SC nanoparticles). The formation of 188 Re-SC nanoparticles was confirmed by ultraviolet-visible spectrophotometry. The labeling yield of 188 Re-SC nanoparticles was verified using the RTLC method. Effects of synthesis parameters on morphology and size of prepared 188 Re-sulfide colloidal-PLLA microspheres (188 Re-SC-PLLA microspheres) were studied by scanning electron microscopy...
April 12, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29627682/electrically-polarized-plla-nanofibers-as-neural-tissue-engineering-scaffolds-with-improved-neuritogenesis
#6
Nathalie Barroca, Ana Marote, Sandra I Vieira, Abílio Almeida, Maria H V Fernandes, Paula M Vilarinho, Odete A B da Cruz E Silva
Tissue engineering is evolving towards the production of smart platforms exhibiting stimulatory cues to guide tissue regeneration. This work explores the benefits of electrical polarization to produce more efficient neural tissue engineering platforms. Poly (l-lactic) acid (PLLA)-based scaffolds were prepared as solvent cast films and electrospun aligned nanofibers, and electrically polarized by an in-lab built corona poling device. The characterization of the platforms by thermally stimulated depolarization currents reveals a polarization of 60 × 10-10 C cm-2 that is stable on poled electrospun nanofibers for up to 6 months...
March 30, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29622085/l-inermis-loaded-nanofibrous-scaffolds-for-wound-dressing-applications
#7
Saeid Vakilian, Mohammad Norouzi, Mahsa Soufi-Zomorrod, Iman Shabani, Simzar Hosseinzadeh, Masoud Soleimani
Since ancient times, some herbal medicines have been extensively used for burn and wound treatments, showing preference to the common synthetic medications by virtue of having less side effects and faster healing rate. In this study, hybrid nanofibrous scaffolds of poly-l-lactic-acid (PLLA) and gelatin incorporated L. inermis were fabricated via electrospinning technique. Morphology and characteristics of the scaffolds were studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively...
April 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29601509/tactile-sliding-behavior-of-r2r-mass-produced-plla-nanosheet-towards-biomedical-device-in-skin-applications
#8
Sheng Zhang, Yoshitomo Kai, Yuta Sunami
In this research, sliding friction was measured between the fingertip and nanosheet on a silicon substrate under two conditions: dry and wet. By using a force transducer, the tactile friction force and applied load were measured. According to the experimental results, the relationship of friction force and applied load exhibits a positive correlation under both dry and wet conditions. In addition, the nanosheets are able to reduce the friction force and coefficient of friction (COF) compared to the reference sample, especially under the wet condition...
March 30, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29599615/biomimetic-mineralized-strontium-doped-hydroxyapatite-on-porous-poly-l-lactic-acid-scaffolds-for-bone-defect-repair
#9
Min Ge, Kun Ge, Fei Gao, Weixiao Yan, Huifang Liu, Li Xue, Yi Jin, Haiyun Ma, Jinchao Zhang
Introduction: poly(l-lactic acid) (PLLA) has been approved for clinical use by the US Food and Drug Administration (FDA); however, their stronger hydrophobicity and relatively fast degradation rate restricted their widespread application. In consideration of the composition of bone, the inorganic-organic composite has a great application prospect in bone tissue engineering. Many inorganic-organic composite scaffolds were prepared by directly mixing the active ingredient, but this method is uncontrolled and will lead to lack of homogeneity in the polymer matrix...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29570761/treatment-of-lateral-tibial-condylar-fractures-using-bioactive-bioresorbable-forged-composites-of-raw-particulate-unsintered-hydroxyapatite-poly-l-lactide-screws
#10
Gen Kuroyanagi, Hiroyuki Yoshihara, Naohiro Yamamoto, Hiroyuki Suzuki, Kunio Yamada, Yukio Yoshida, Takanobu Otsuka, Naoya Takada
Forged composites of raw particulate unsintered hydroxyapatite/poly-L-lactide (F-u-HA/PLLA) devices possess high mechanical strength, bioactivity, and radio-opacity. The aim of this study was to assess the efficacy of F-u-HA/PLLA screws in the treatment of lateral tibial condylar fractures. From January 2005 to December 2010, a total of 7 patients with displaced closed lateral tibial condylar fractures (Schatzker type II) were treated using F-u-HA/PLLA screws. Open reduction and internal fixation was performed using 2 or 3 F-u-HA/PLLA screws...
March 23, 2018: Orthopedics
https://www.readbyqxmd.com/read/29563370/successful-surgical-fixation-using-bio-absorbable-plates-for-frail-chest-in-a-severe-osteoporotic-octogenarian
#11
Ryuichi Waseda, Isao Matsumoto, Yasuhiko Tatsuzawa, Akinori Iwasaki
We present a case of a severe osteoporotic octogenarian who sustained serious flail chest from a traffic accident. The 3rd-9th ribs of the right chest wall were fractured. Non-operative management was unsuccessful. We performed a surgical fixation using a bio-absorbable and bio-active mini-plating set. This plating set is unsintered hydroxyapatite (u-HA) particles/poly-L-lactide (PLLA) composite osteosynthesis device commonly used for cranial, oral, and maxillofacial surgeries. The use of the u-HA/PLLA device for chest wall reconstruction has previously been reported, but no long-term results have been included...
March 22, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29549950/enhanced-bone-regeneration-composite-scaffolds-of-plla-%C3%AE-tcp-matrix-grafted-with-gelatin-and-hap
#12
Jie-Lin Wang, Qian Chen, Bei-Bei Du, Lu Cao, Hong Lin, Zhong-Yong Fan, Jian Dong
The composite polylactide PLLA/β-TCP scaffolds were fabricated by solution casting and were coated with gelatin/hydroxyapatite (Gel/HAp) to improve the biological properties of the composite scaffolds. The Gel/HAp mixture was prepared using an in situ reaction, and a grafting-coating method was used to increase the efficiency of coating the PLLA/β-TCP matrix with Gel/HAp. First, free amino groups were introduced by 1,6-hexanediamine to aminolyze the PLLA/β-TCP matrix surface. Second, glutaraldehyde was coupled to Gel/HAp as a crosslinking agent...
June 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29532357/novel-approach-for-a-ptx-vegf-dual-drug-delivery-system-in-cardiovascular-applications-an-innovative-bulk-and-surface-drug-immobilization
#13
Katharina Wulf, Michael Teske, Claudia Matschegewski, Daniela Arbeiter, Dalibor Bajer, Thomas Eickner, Klaus-Peter Schmitz, Niels Grabow
The successive incorporation of several drugs into the polymeric bulk of implants mostly results in loss of considerable quantity of one drug, and/or the loss in quality of the coating and also in changes of drug release time points. A dual drug delivery system (DDDS) based on poly-L-lactide (PLLA) copolymers combining the effective inhibition of smooth muscle cell proliferation while simultaneously promoting re-endothelialization was successfully developed. To overcome possible antagonistic drug interactions and the limitation of the polymeric bulk material as release system for dual drugs, a novel concept which combines the bulk and surface drug immobilization for a DDDS was investigated...
March 12, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29531341/effects-of-amphiphilic-chitosan-on-stereocomplexation-and-properties-of-poly-lactic-acid-nano-biocomposite
#14
Arvind Gupta, Akhilesh Kumar Pal, Eamor M Woo, Vimal Katiyar
This article demonstrates an elegant approach for the fabrication of high heat-stable PLA using an industrially viable technique i.e. melt extrusion, which is quite challenging due to the higher viscosity of poly(lactic acid) melt. scPLA has been fabricated by melt extrusion of PLLA/PDLA using nano-amphiphilic chitosan (modified chitosan, MCH) which has been synthesized by grafting chitosan with oligomeric PLA via insitu polycondensation of L-lactic acid that possibly increases the molecular surface area and transforms it into nano-amphiphilic morphology and in turn lead to the formation of stereocomplex crystallites...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29523214/polymer-mineral-scaffold-augments-in-vivo-equine-multipotent-stromal-cell-osteogenesis
#15
Wei Duan, Cong Chen, Masudul Haque, Daniel Hayes, Mandi J Lopez
BACKGROUND: Use of bioscaffolds to direct osteogenic differentiation of adult multipotent stromal cells (MSCs) without exogenous proteins is a contemporary approach to bone regeneration. Identification of in vivo osteogenic contributions of exogenous MSCs on bioscaffolds after long-term implantation is vital to understanding cell persistence and effect duration. METHODS: This study was designed to quantify in vivo equine MSC osteogenesis on synthetic polymer scaffolds with distinct mineral combinations 9 weeks after implantation in a murine model...
March 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29498970/influence-of-backscatter-radiation-on-cranial-bone-fixation-devices
#16
Yoshiaki Sakamoto, Naoyoshi Koike, Hideyuki Takei, Mari Ohno, Naoyuki Shigematsu, Kazuo Kishi
Postoperative radiation can cause ulcer formation, leading to the denudation of skin over alloplastic materials. The influence of backscatter radiation from fixation devices has not been investigated. The aim of this study is to evaluate backscatter dose variations for different cranial bone fixation devices in an experimental model designed to simulate postoperative radiotherapy. The authors assessed the radiation backscatter doses associated with resorbable (PLLA-PGA) and titanium plates. The samples were irradiated with 6 and 10 MV photon beams from a linear accelerator...
March 1, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29490758/preparation-of-hydrogel-based-on-poly-ester-amine-pea-for-bilirubin-removal
#17
Yi Yang, Kun Shi, Jinrong Peng, Zhiyong Qian
Hyperbilirubinemia, caused by the disorders in bilirubin metabolism, could result in neurotoxicity, permanent brain damage and even death. As one of effective bilirubin removal technologies from blood, hemoperfusion had attracted much attention. However, the development of bilirubin adsorbents used in hemoperfusion with excellent adsorption capacity and hemocompatibility still faced great challenges. In this work, the cationic hydrogel was prepared by the photo-initiated polymerization of biodegradable poly(ester amine) (PEA) based on PLLA and low molecular weight PEI1800...
December 1, 2017: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29488745/enhanced-interfacial-adhesion-by-reactive-carbon-nanotubes-new-route-to-high-performance-immiscible-polymer-blend-nanocomposites-with-simultaneously-enhanced-toughness-tensile-strength-and-electrical-conductivity
#18
Xuewen Zhao, Hengti Wang, Zhiang Fu, Yongjin Li
Physically anchoring carbon nanotubes (CNTs) onto the interface of immiscible polymer blends has been extensively reported; however, enhancement of physical properties of the blends has seldom been achieved. Herein, we used CNTs with reactive epoxide groups and long polymethyl methacrylate (PMMA) tails as a thermodynamic compatibilizer for immiscible poly vinylidene fluoride/poly L-lactide (PVDF/PLLA) blends. The CNTs acted as an efficient compatibilizer and bridged the two phases through physical entanglement and chemical reaction...
February 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29486602/generation-of-insulin-producing-cells-from-human-induced-pluripotent-stem-cells-on-plla-pva-nanofiber-scaffold
#19
Seyed Ehsan Enderami, Mousa Kehtari, Mohammad Foad Abazari, Pegah Ghoraeian, Maryam Nouri Aleagha, Fatemeh Soleimanifar, Masoud Soleimani, Yousef Mortazavi, Samad Nadri, Hossein Mostafavi, Hassan Askari
Pancreatic tissue engineering as a therapeutic option for restoring and maintenance of damaged pancreas function has a special focus to using synthetic Scaffolds. This study was designed to evaluate pancreatic differentiation of human induced pluripotent stem cells (hiPSCs) on poly-L-lactic acid and polyvinyl alcohol (PLLA/PVA) scaffolds as 3 D matrix. During differentiation process, morphology of cells gradually changed and iPSCs derived insulin producing cells (iPSCs-IPCs) formed spherical shaped cell aggregation that was the typical shape of islets of pancreas...
February 27, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29485108/fabrication-characterization-and-in-vitro-evaluation-of-triboelectric-nanogenerator-based-on-317l-stainless-steel-and-polylactic-acid
#20
Wei Li, Xiaoxue Xu, Wenjiang Li, Yun Zhao, Minfang Chen
A novel, cost-effective biomedical triboelectric nanogenerator (TENG) has been fabricated based on biocompatible medical 317L stainless steel (317L SS) and polylactic acid (PLLA) films as the friction layers, whose surface roughness designed by simple and low-cost laser etching and hot-embossing template methods, respectively. With the increase of the TENG's tribo-interface roughness and the molecular weight of the PLLA, the power output of TENG was greatly increased owing to more charges produced and excellent mechanical properties of PLLA possessed...
February 27, 2018: Nanotechnology
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