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Xingxing Zhou, Anneng Yang, Zhongbing Huang, Guangfu Yin, Ximing Pu, Juan Jin
Extracellular matrix (ECM) can promote peripheral nerve repair. In this study, a conductive fiber-film (CFF) with core-sheath structure and conductivity of ∼10Scm(-1) was prepared by electrospinning of aligned poly(l-lactide acid) (PLLA) fibers and electrochemical deposition of polypyrole (PPy) nanoparticles. Then the multiple components of ECM, including laminin, fibronectin and collagen, were coated on the surface of CFF by culturing and lysing L929 cells to fabricate the bioactive scaffold of ECM-linked CFF (ECM-CFF)...
October 11, 2016: Colloids and Surfaces. B, Biointerfaces
Mohammad Samiei, Marziyeh Aghazadeh, Effat Alizadeh, Naser Aslaminabadi, Soodabeh Davaran, Sajjad Shirazi, Farhad Ashrafi, Roya Salehi
Purpose: Statin is an effective factor for promoting osteogenesis. The aim of the present study was to evaluate the effect of simvastatin (SIM) and/or HA addition on changes in osteogenesis levels by human DPSCs transferred onto three-dimensional (3D) nanofibrous Poly (ε-caprolactone) (PCL)/Poly lactic acide (PLLA) polymeric scaffolds. Methods: For this purpose, a 3D nanofibrous composite scaffold of PCL/PLLA/HA was prepared by electrospinning method. SIM was added to scaffolds during DPSCs culturing step...
September 2016: Advanced Pharmaceutical Bulletin
Ana Marina Ferreira, Piergiorgio Gentile, Sotiria Toumpaniari, Gianluca Ciardelli, Mark A Birch
Bone cell interaction with extracellular matrix (ECM) microenvironment is of critical importance when engineering surface interfaces for bone regeneration. In this work layer-by-layer films of type I collagen (coll), the major constituent of bone ECM, and heparin (hep), a glycosaminoglycan, were assembled on poly(L-lactide acid) (PLLA) substrates to evaluate the impact of the biomacromolecular coating on cell activity. The surface modification of PLLA demonstrated that the hep/coll multi-layer is stable after 10 bilayers (confirmed by contact angle, infrared spectroscopy and morphological analysis)...
October 20, 2016: ACS Applied Materials & Interfaces
Takahiro Kaneko, Satoshi Nakamura, Shunsuke Hino, Norio Horie, Tetsuo Shimoyama
BACKGROUND: Sinus lift is a bone augmentation procedure that improves the alveolar crest height in an atrophic posterior maxilla. However, the regenerated bone volume can vary and generally has a tendency to decrease after sinus operation. This article describes nongrafted maxillary sinus lift using a bioresorbable unsintered hydroxyapatite combined with poly L-lactide (HA/PLLA) mesh plate device and dental implant placement in an atrophic posterior maxilla, after which continuous bone gain was observed around the implant apex during a postoperative follow-up period of 3 years...
December 2016: Int J Implant Dent
Luiz Alexandre Chisini, Marcus Cristian Muniz Conde, Jose Carlos Bernedo Alcázar, Adriana Fernandes da Silva, Jacques Eduardo Nör, Sandra Beatriz Chaves Tarquinio, Flávio Fernando Demarco
The aim of the present study was to evaluate the expression of transforming growth factor-β1 (TGF-β1) and osteonectin (ON) in pulp-like tissues developed by tissue engineering and to compare it with the expression of these proteins in pulps treated with Ca(OH)2 therapy. Tooth slices were obtained from non-carious human third molars under sterile procedures. The residual periodontal and pulp soft tissues were removed. Empty pulp spaces of the tooth slice were filled with sodium chloride particles (250-425 µm)...
October 10, 2016: Brazilian Oral Research
Akshit Peer, Rabin Dhakal, Rana Biswas, Jaeyoun Kim
We compare the rates of drug release from nanopatterned and flat biodegradable polymer surfaces, and observe significantly lower release rates from the nanopatterned surfaces. Specifically, we nanopattern poly(l-lactic acid) (PLLA), a biodegradable polymer frequently used for fabricating drug-eluting coronary stents, through microtransfer molding and solvent casting and investigate the nanopattern's impact on the release of sirolimus, an immunosuppressant agent, coated on the PLLA surface using high performance liquid chromatography/mass spectrometry...
October 5, 2016: Nanoscale
Huihua Yuan, Jinbao Qin, Jing Xie, Biyun Li, Zhepao Yu, Zhiyou Peng, Bingcheng Yi, Xiangxin Lou, Xinwu Lu, Yanzhong Zhang
This study was designed to assess the efficacy of hyaluronan (HA) functionalized well-aligned nanofibers of poly-l-lactic acid (PLLA) in modulating the phenotypic expression of vascular smooth muscle cells (vSMCs) for blood vessel regeneration. Highly aligned HA/PLLA nanofibers in core-shell structure were prepared using a novel stable jet electrospinning approach. Formation of a thin HA-coating layer atop each PLLA nanofiber surface endowed the uni-directionally oriented fibrous mats with increased anisotropic wettability and mechanical compliance...
September 15, 2016: Nanoscale
Piming Ma, Tianfeng Shen, Long Lin, Weifu Dong, Mingqing Chen
Comb-like nanocrystal cellulose graft poly (d-lactide) (PDLA), i.e., NCC-g-PDLA nanohybrids were synthesized and compounded with poly (l-lactide) (PLLA) and poly (hydroxyalkanoate)s (PHA) to make fully biobased nanocomposites. Surprisingly, the complex viscosity of the PLLA/PHA melts was reduced by more than one order of magnitudes, viz. from 4000 to 100Pas by incorporation of 2-4wt% of the NCC-g-PDLA nanohybrids. Meanwhile, the crystallization of the PLLA component was accelerated by the NCC-g-PDLA nanohybrids due to the strong interaction between PDLA and PLLA macromolecules...
January 2, 2017: Carbohydrate Polymers
Hideto Tsuji, Michiaki Ogawa, Yuki Arakawa
Star-shaped four-armed stereo diblock copolymers with an amorphous poly(DL-lactide) (PDLLA) core and a crystalline poly(L-lactide) (PLLA) or poly(D-lactide) (PDLA) shell (4-DL-L and 4-DL-D) and with a crystalline PLLA or PDLA core and amorphous PDLLA shell (4-L-DL and 4-D-DL) copolymers were synthesized. The effects of incorporation and position of amorphous PDLLA blocks on homo- and stereocomplex (SC) crystallization behavior of unblended copolymers and their blends (4-DL-L/4-DL-D and 4-L-DL/4-D-DL) were investigated during isothermal crystallization from the melt and DSC heating...
October 4, 2016: Journal of Physical Chemistry. B
Ezequiel Ernesto Zaidenberg, Pablo Roitman, Gerardo Luis Gallucci, Jorge Guillermo Boretto, Pablo De Carli
Background: In recent years the use of biodegradable suture anchors for treating tendon and ligament pathology in hand surgery became popular. These materials are biocompatible, radiolucent, and load sharing, as they incrementally transfer load to surrounding bone during the resorption process. Despite these numerous advantages, polyglycolic (PGA) and poly-L-lactic acid (PLLA) have become a problem because of the potential risk for foreign body reactions. Methods: This article presents a case of an intraosseous foreign body reaction and massive osteolysis of the proximal carpal after dorsal lunate dislocation repair with bioabsorbable suture anchors...
September 2016: Hand: Official Journal of the American Association for Hand Surgery
Zhen Li, Liang Sun, Yufei Zhang, Andrew P Dove, Rachel K O'Reilly, Guosong Chen
The shells of various poly(dl-lactide)-b-poly(acrylic acid) (PDLLA-b-PAA) spherical micelles and poly(l-lactide)-b-poly(acrylic acid) (PLLA-b-PAA) cylindrical micelles were functionalized with mannose to yield glyco-nanoparticles (GNPs) with different shapes and dimensions. All of these GNPs were shown to have good biocompatibility (up to 1 mg/mL). Cellular uptake experiments using RAW 264.7 have shown that the spherical GNPs were internalized to a much greater extent than the cylindrical GNPs and such a phenomenon was attributed to their different endocytosis pathways...
September 20, 2016: ACS Macro Letters
Metin Uz, Anup D Sharma, Pratish Adhikari, Donald S Sakaguchi, Surya K Mallapragada
: In this study, a poly(lactic acid) (PLLA) porous film with longitudinal surface micropatterns was fabricated by a dry phase inversion technique to be used as potential conduit material for peripheral nerve regeneration applications. The presence of a nerve growth factor (NGF) gradient on the patterned film surface and protein loaded, surface-eroding, biodegradable, and amphiphilic polyanhydride (PA) microparticles within the film matrix, enabled co-delivery of neurotrophic factors with controlled release properties and enhanced neurite outgrowth from PC12 cells...
September 29, 2016: Acta Biomaterialia
Artemis Ailianou, Karthik Ramachandran, Mary Beth Kossuth, James Paul Oberhauser, Julia A Kornfield
Poly(l-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery...
September 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
Nilüfer Çakır-Özkan, Sinan Eğri, Esengül Bekar, B Zuhal Altunkaynak, Yonca Betil Kabak, Elfide Gizem Kıvrak
PURPOSE: Promising developments have materialized in reconstructive surgical procedures with the applications of tissue engineering. In our study, we used tissue scaffolds fabricated from polylactic acid-polyethylene glycol (PLLA-PEG) copolymers to ensure different release rates of selective growth factors recombinant human bone morphogenetic protein 2 [rhBMP-2] and vascular endothelial growth factor (rhVEGF165) in the repair of mandibular bone defects. MATERIALS AND METHODS: In our experimental study, 54 New Zealand rabbits were used...
August 27, 2016: Journal of Oral and Maxillofacial Surgery
Jae Won Choi, Yeon Soo Kim, Ju Kyeong Park, Eun Hye Song, Ji Hoon Park, Moon Suk Kim, Yoo Seob Shin, Chul-Ho Kim
An in situ-forming gel system comprised of diblock copolymer formed from polyethylene glycol (PEG) and polycaprolactone (PCL) {MPEG-b-(PCL-ran-PLLA)} could be used in controlled drug delivery for tissue remodeling. The purpose of this study is to demonstrate favorable vocal folds (VF) regeneration by using MPEG-b-(PCL-ran-PLLA) diblock copolymers (C97L3; CL/LA ratio 97:3) incorporating hepatocyte growth factor (HGF). Gradual release of HGF from C97L3 is detected and biochemical properties of released HGF are maintained...
September 20, 2016: Macromolecular Bioscience
Jiaqi Chu, Shaodong Zeng, Liyang Gao, Thomas Groth, Zhiwen Li, Junchao Kong, Mingyan Zhao, Lihua Li
PURPOSE: Polymer porous scaffolds and hydrogels have been separately employed and explored for a wide range of applications including cell encapsulation, drug delivery, and tissue engineering. METHODS: In this study, a three-dimensional poly (L-lactic acid) (PLLA) scaffold with interconnected and homogeneously distributed pores was fabricated to support the alginate hydrogel (Alg). The gels were filled into the porous scaffold, which acted as an analogue of native extracellular matrix (ECM) for entrapment of cells within a support of predefined shape...
October 10, 2016: International Journal of Artificial Organs
Qian Wang, Gang Fang, Yinghong Zhao, Guohui Wang, Tao Cai
Poly-L-lactide Acid (PLLA), as a credible biodegradable polymer-based material, can provide a promising amount of degradation time for vessel remodeling. Served as a sort of reliable intravascular implants, PLLA stents are expected to provide sufficient scaffolding to the target arteries without generating too much recoil after deployment. Besides, the stress and strain distribution should be as homogeneous as possible, and the stent conformability in fitting to the nature curvature of the vessels needs to be guaranteed...
August 31, 2016: Journal of the Mechanical Behavior of Biomedical Materials
H Maleki, A A Gharehaghaji, T Toliyat, P J Dijkstra
In this study, twisted drug-loaded poly(L-lactide) (PLLA) and hybrid poly(L-lactide)/poly(vinyl alcohol) (PLLA/PVA) yarns were produced using an electrospinning technique based on two oppositely charged nozzles. Cefazolin, an antibiotic drug was incorporated in the yarn fibers by addition to the PLLA electrospinning solution. Morphological studies showed that independent of the twist rate, uniform and smooth fibers were formed. The diameter of the electrospun fibers in the yarns decreased at higher twist rates but produced yarns with larger diameters...
2016: Biofabrication
Kyung-Hye Jung, John P Ferraris
Porous carbon nanofibers were prepared by electrospinning blend solutions of polybenzimidazole/poly-L-lactic acid (PBI/PLLA) and carbonization. During thermal treatment, PLLA was decomposed, resulting in the creation of pores in the carbon nanofibers. From SEM images, it is shown that carbon nanofibers had diameters in the range of 100-200 nm. The conversion of PBI to carbon was confirmed by Raman spectroscopy, and the surface area and pore volume of carbon nanofibers were determined using nitrogen adsorption/desorption analyses...
October 21, 2016: Nanotechnology
Pei Feng, Shuping Peng, Ping Wu, Chengde Gao, Wei Huang, Youwen Deng, Cijun Shuai
In this study, the mechanical strength and modulus of poly(L-lacti acid) (PLLA) scaffolds were enhanced with the mechanical properties of boron nitride nanosheets (BNNSs) and tetraneedlelike ZnO whiskers (T-ZnOw). The adhesion and proliferation of cells were improved as well as osteogenic differentiation of stem cells was increased. Their dispersion statues in PLLA matrix were improved through a space network structure constructed by three-dimensional T-ZnOw supporting two-dimensional BNNSs. The results showed that the compressive strength, modulus and Vickers hardness of the scaffolds with incorporation of 1 wt% BNNSs and 7 wt% T-ZnOw together were about 96...
2016: Scientific Reports
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