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https://www.readbyqxmd.com/read/28110114/tropoelastin-coated-plla-plga-scaffolds-promote-vascular-network-formation
#1
Shira Landau, Ariel A Szklanny, Giselle C Yeo, Yulia Shandalov, Elena Kosobrodova, Anthony S Weiss, Shulamit Levenberg
The robust repair of large wounds and tissue defects relies on blood flow. This vascularization is the major challenge faced by tissue engineering on the path to forming thick, implantable tissue constructs. Without this vasculature, oxygen and nutrients cannot reach the cells located far from host blood vessels. To make viable constructs, tissue engineering takes advantage of the mechanical properties of synthetic materials, while combining them with ECM proteins to create a natural environment for the tissue-specific cells...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28102777/comparison-of-early-vascular-morphological-changes-between-bioresorbable-poly-l-lactic-acid-scaffolds-and-metallic-stents-in-porcine-iliac-arteries
#2
Yasuhito Sekimoto, Hideaki Obara, Kentaro Matsubara, Naoki Fujimura, Hirohisa Harada, Yuko Kitagawa
Bioresorbable scaffolds have the potential to overcome several problems associated with metallic stents. Bioresorbable poly-L-lactic acid (PLLA) scaffold implantation for the treatment of peripheral artery disease has already been reported in animal models and clinical trials; however, no studies comparing PLLA scaffolds and bare metal stents (BMSs) with regard to early vascular morphological changes, identified using intravascular ultrasound (IVUS) analysis, have been reported. In this study, PLLA scaffolds and BMSs were implanted bilaterally in iliac arteries of five miniature pigs...
January 19, 2017: Organogenesis
https://www.readbyqxmd.com/read/28093043/electrospun-yarn-reinforced-nanoha-composite-matrix-as-a-potential-bone-substitute-for-enhanced-regeneration-of-segmental-defects
#3
Anitha A Nair, John Joseph, Deepthy Menon, Shantikumar Nair, Manitha Nair
Nanohydroxyapatite (HA) is a well-established synthetic bone substitute with excellent osteoconduction and osteointegration. However, brittleness coupled with slow degradation curtail its load bearing and bone regeneration potential respectively. To address these limitations, nanoHA composite matrix reinforced with electrospun 1D fibrous yarns was fabricated and tested in vitro and in vivo. Different weight percentages (5, 10, 15 wt%) and varying lengths (short and continuous) of PLLA yarns were randomly dispersed in a gelatinous matrix containing nanoHA...
January 17, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28079309/bioactive-injectable-aggregates-with-nanofibrous-microspheres-and-human-dental-pulp-stem-cells-a-translational-strategy-in-dental-endodontics
#4
I Garzón, M A Martin-Piedra, V Carriel, M Alaminos, X Liu, R D Souza
Regeneration of the pulp-dentin complex with stem cells is a potential alternative to conventional root canal treatments. Human dental pulp stem cells (hDPSCs) have been extensively studied because of their ability to proliferate and differentiate into mineralized dental and nondental tissues. In this work we combined hDPSCs with two types of injectable poly-L-lactic acid (PLLA) microspheres with a nanofibrous or smooth surface to form bioactive injectable aggregates, and examined their ability to promote pulp regeneration in the root canal in an in vivo model...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28070698/drug-coated-microneedles-for-rapid-and-painless-local-anesthesia
#5
Sung-Hyun Baek, Ju-Hyung Shin, Yeu-Chun Kim
This study showed that drug-coated PLLA (Poly (L-lactide)) microneedle arrays can induce rapid and painless local anesthesia. Microneedle arrays were fabricated using a micro-molding technique, and the needle tips were coated with 290.6 ± 45.9 μg of lidocaine, the most widely used local anesthetic worldwide. A dip-coating device was newly designed for the coating step using an optimized coating formulation. Lidocaine coated on the arrays was released rapidly into PBS within 2 min, and its stability in storage lasted 3 weeks at 4, 25, and 37°C...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28064009/targeted-sustained-delivery-of-antineoplastic-agent-with-multicomponent-polylactide-stereocomplex-micelle
#6
Kexin Shen, Di Li, Jingjing Guan, Jianxun Ding, Zhongtang Wang, Jingkai Gu, Tongjun Liu, Xuesi Chen
A c(RGDfC)-decorated polylactide stereocomplex micelle (cRGD-SCM) was prepared through the stereocomplex and hydrophobic interactions among 4-arm poly(ethylene glycol)-block-poly(D-lactide) (4-arm PEG-b-PDLA), methoxy poly(ethylene glycol)-block-poly(L-lactide) (mPEG-b-PLLA), and c(RGDfC)-poly(ethylene glycol)-block-poly(L-lactide) (cRGD-PEG-b-PLLA) for targeted treatment of αvβ3 integrin-positive C26 colon cancer. Doxorubicin (DOX), a model antitumor drug, was loaded into cRGD-SCM with a diameter of approximately 100nm, and the drug loading efficiency was 45...
January 5, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28054502/enhanced-ph-stability-cell-viability-and-reduced-degradation-rate-of-poly-l-lactide-based-composite-in-vitro-effect-of-modified-magnesium-oxide-nanoparticles
#7
Jinjun Yang, Xiuxiang Cao, Yun Zhao, Liang Wang, Bei Liu, Junping Jia, Hui Liang, Minfang Chen
The modified MgO nanoparticles (m-MgO-NPs) by a copolymer containing the malic acid and low molecular weight (LMW) poly(L-lactide) (poly(L-lactide-co-malic acid), PLMA) have been successfully prepared. MgO nanoparticles (MgO-NPs) were coated by the PLMA and m-MgO-NPs were uniformly dispersed in the PLLA matrix to a novel biocomposite material (PLLA/m-MgO-NPs) with more excellent interface bonding and uniformer dispersion, compared to the PLLA/MgO-NPs. Compared to neat PLLA and PLLA/MgO-NPs film, the m-MgO-NPs not only shown the obvious neutralization effect on the acidic solution in the degradation of the PLLA and better hydrophilicity, but also exhibited the higher cell viability and decrease the toxicity to the cell in the degradation process of PLLA in vitro...
January 5, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28052196/dna-nanostructures-mediated-molecular-imprinting-lithography
#8
Cheng Tian, Hyojeong Kim, Wei Sun, Yunah Kim, Peng Yin, Haitao Liu
This paper describes the fabrication of polymer stamps using DNA nanostructure templates. This process creates stamps having diverse nanoscale features with dimensions ranging from several tens of nanometers to micrometers. DNA nanostructures including DNA nanotubes, stretched λ-DNA, two-dimensional (2D) DNA brick crystals with three-dimensional (3D) features, hexagonal DNA 2D arrays, and triangular DNA origami were used as master templates to transfer patterns to poly(methyl methacrylate) and poly(l-lactic acid) with high fidelity...
January 10, 2017: ACS Nano
https://www.readbyqxmd.com/read/28051358/controlled-retention-of-bmp-2-derived-peptide-on-nanofibers-based-on-mussel-inspired-adhesion-for-bone-formation
#9
Jinkyu Lee, Sajeesh Kumar Mp, Taufiq Ahmad, Min Suk Lee, Heeseok Yang, Do-Gyoon Kim, Kyobum Kim, Bosun Kwon, Heungsoo Shin
Although bone morphogenetic protein-2 (BMP-2) has been frequently used to stimulate bone formation, it has several side effects to be addressed, including the difficulty in optimization of clinically relevant doses and unwanted induction of cancerous signaling processes. In this study, an osteogenic peptide (OP) derived from BMP-2 was investigated as a substitute for BMP-2. In vitro studies showed that OP was able to enhance in the osteogenic differentiation and mineralization of human mesenchymal stem cells (hMSCs)...
January 4, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28039620/primordial-germ-cell-differentiation-of-nuclear-transfer-embryonic-stem-cells-using-surface-modified-electroconductive-scaffolds
#10
Tarlan Eslami-Arshaghi, Saeid Vakilian, Ehsan Seyedjafari, Abdolreza Ardeshirylajimi, Masoud Soleimani, Mohammad Salehi
A combination of nanotopographical cues and surface modification of collagen and fibronectin is a potential platform in primordial germ cells (PGCs) differentiation. In the present study, the synergistic effect of nanotopography and surface modification on differentiation of nuclear transfer embryonic stem cells (nt-ESCs) toward PGC lineage was investigated. In order to achieve this goal, poly-anyline (PANi) was mix within poly-L-lactic acid (PLLA). Afterward, the random composite mats were fabricated using PLLA and PANi mix solution...
December 30, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28039591/visualizing-polymeric-bioresorbable-scaffolds-with-three-dimensional-image-reconstruction-using-contrast-enhanced-micro-computed-tomography
#11
Sheng Tu, Fudong Hu, Wei Cai, Liyan Xiao, Linlin Zhang, Hong Zheng, Qiong Jiang, Lianglong Chen
There are no previous studies showing how to visualize polymeric bioresorbable scaffolds (BRSs) by micro-computed tomography (mCT). There are no previous studies showing how to visualize polymeric bioresorbable scaffolds (BRSs) by micro-computed tomography (mCT). This study aimed to explore the feasibility of detecting polymeric BRS with 3-dimensional reconstruction of BRS images by contrast-enhanced mCT and to determine the optimal imaging settings. BRSs, made of poly-L-lactic acid (PLLA), were implanted in coronary bifurcation models...
December 30, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28032150/ocular-pain-and-impending-blindness-during-facial-cosmetic-injections-is-your-office-prepared
#12
Giselle Prado, Jose Rodríguez-Feliz
: Soft tissue filler injections are the second most common non-surgical procedure performed by the plastic surgeon. Embolization of intravascular material after facial injection is a rare but terrifying outcome due to the high likelihood of long-term sequela such as blindness and cerebrovascular accident. The literature is replete with examples of permanent blindness caused by injection with autologous fat, soft tissue fillers such as hyaluronic acid, PLLA, calcium hydroxyl-apatite, and even corticosteroid suspensions...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28024589/temperature-responsive-plla-pnipam-nanofibers-for-switchable-release
#13
Roman Elashnikov, Petr Slepička, Silvie Rimpelova, Pavel Ulbrich, Vaclav Švorčík, Oleksiy Lyutakov
Smart antimicrobial materials with on-demand drug release are highly desired for biomedical applications. Herein, we report about temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) nanospheres doped with crystal violet (CV) and incorporated into the poly-l-lactide (PLLA) nanofibers. The nanofibers were prepared by electrospinning, using different initial polymers ratios. The morphology of the nanofibers and polymers distribution in the nanofibers were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024575/effect-of-mg-content-on-the-thermal-stability-and-mechanical-behaviour-of-plla-mg-composites-processed-by-hot-extrusion
#14
S C Cifuentes, M Lieblich, F A López, R Benavente, J L González-Carrasco
In the field of bioabsorbable composites for biomedical applications, extrusion has been employed as a method to prepare homogeneous blends of polymeric matrices with bioactive ceramic fillers. In this work, the suitability of processing poly-l-lactic acid/Magnesium (PLLA/Mg) composites by hot extrusion has been assessed by a systematic characterization of PLLA/Mg composites containing different amounts of Mg particles up to 7wt%. The results show that extrusion causes a reduction of almost 20% in the viscosity average molecular weight of PLLA, which further decreases with increasing Mg content...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024094/effect-on-surface-character-and-mechanical-property-of-unsintered-hydroxyapatite-poly-l-lactic-acid-uha-plla-material-by-uv-treatment
#15
Akinori Moroi, Masaki Okuno, Go Kobayashi, Hitoshi Gamo, Izumi Serizawa, Kunio Yoshizawa, Hiroumi Ikawa, Koichiro Ueki
Materials fabricated with unsintered hydroxyapatite/poly-l-lactic acid (uHA/PLLA) exhibit biological activity and biocompatibility, but are also hydrophobic. This hydrophobicity limits the ability of cells or tissues to adhere to the surface of the material and thereby prevents the materials from exhibiting effective biological activity. In this study, we examined the effects of ultraviolet (UV) treatment on the hydrophobicity of uHA/PLLA. We compared the contact angle, mechanical strength, cell attachment, and cell differentiation capacity between untreated uHA/PLLA and uHA/PLLA treated with UV light...
December 26, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28018952/change-in-thermal-transitions-and-water-uptakes-of-poly-l-lactic-acid-blends-upon-hydrolytic-degradation
#16
Hideko T Oyama, Daisuke Tanishima, Shintaro Maekawa
This article reports experimental data related to the research article entitled "Poly(malic acid-co-l-lactide) as a Superb Degradation Accelerator for Poly(l-lactic acid) at Physiological Conditions" (H.T. Oyama, D. Tanishima, S. Maekawa, 2016) [1]. Hydrolytic degradation of poly(l-lactic acid) (PLLA) blends with poly(aspartic acid-co-l-lactide) (PAL) and poly(malic acid-co-l-lactide) (PML) oligomers was investigated in a phosphate buffer solution at 40 °C. It was found in the differential scanning calorimetry measurements that upon hydrolysis the cold crystallization temperature (Tc ) and the melting temperature (Tm ) significantly shifted to lower temperature...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27999810/development-of-a-new-hybrid-biodegradable-drug-eluting-stent-for-the-treatment-of-peripheral-artery-disease
#17
Jung-Hee Lee, Soon-Joong Kim, Se-Il Park, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n = 5), a drug-free hybrid stent (group 2, n = 5), a 50% (50 : 100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n = 5), and a 30% (30 : 100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n = 5)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27998842/four-year-polymer-biocompatibility-and-vascular-healing-profile-of-a-novel-ultrahigh-molecular-weight-amorphous-plla-bioresorbable-vascular-scaffold-an-oct-study-in-healthy-porcine-coronary-arteries
#18
Torsten P Vahl, Pawel Gasior, Carlos A Gongora, Kamal Ramzipoor, Chang Lee, Yanping Cheng, Jenn McGregor, Masahiko Shibuya, Edward A Estrada, Gerard B Conditt, Greg L Kaluz, Juan F Granada
AIMS: The vascular healing profile of polymers used in bioresorbable vascular scaffolds (BRS) has not been fully characterised in the absence of antiproliferative drugs. In this study, we aimed to compare the polymer biocompatibility profile and vascular healing response of a novel ultrahigh molecular weight amorphous PLLA BRS (FORTITUDE®; Amaranth Medical, Mountain View, CA, USA) against bare metal stent (BMS) controls in porcine coronary arteries. METHODS AND RESULTS: Following device implantation, optical coherence tomography (OCT) evaluation was performed at 0 and 28 days, and at one, two, three and four years...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27995585/physical-and-mechanical-characterization-of-plla-interference-screws-produced-by-two-stage-injection-molding-method
#19
Ali Reza Sadeghi-Avalshahr, Mohammad Khorsand-Ghayeni, Samira Nokhasteh, Amir Mahdi Molavi, Mohammad Sadeghi-Avalshahr
The purpose of this study was to produce and evaluate different mechanical, physical and in vitro cell culture characteristics of poly(L-lactic) acid (PLLA) interference screws. This work will focus on evaluating the effect of two important parameters on operation of these screws, first the tunnel diameter which is one of the most important parameters during the operation and second the thermal behavior, the main effective characteristic in production process. In this work, PLLA screws were produced by a two-stage injection molding machine...
December 2016: Progress in biomaterials
https://www.readbyqxmd.com/read/27987706/wetspun-poly-l-lactic-acid-borosilicate-bioactive-glass-scaffolds-for-guided-bone-regeneration
#20
João S Fernandes, Rui L Reis, Ricardo A Pires
We developed a porous poly-L-lactic acid (PLLA) scaffold compounded with borosilicate bioactive glasses (BBGs) endowing it with bioactive properties. Porous PLLA-BBG fibre mesh scaffolds were successfully prepared by the combination of wet spinning and fibre bonding techniques. Micro-computed tomography (μCT) confirmed that the PLLA-BBG scaffolds containing ≈25% of BBGs (w/w) exhibited randomly interconnected porous (58 to 62% of interconnectivity and 53 to 67% of porosity) with mean pore diameters higher that 100μm...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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