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https://www.readbyqxmd.com/read/28531647/multifunctional-plla-ceramic-fiber-membranes-for-bone-regeneration-applications
#1
Daniel Santos, Dina M Silva, Pedro S Gomes, Maria H Fernandes, José D Santos, Vitor Sencadas
A novel method to process electrospun poly(l-lactic acid) (PLLA) membranes incorporating glass reinforced hydroxyapatite granules (gHA) interspacially between the polymeric fibers is reported, thus increasing the surface area for cellular interactions. gHA granules (≤150μm) electrospun together with the polymer solution, lead to an average fiber diameter of 550±150nm for pristine PLLA and 440±170nm for the composite samples. An increase of the overall porosity was observed, from 79±3% for the PLLA up to 88±5% for the hybrid samples, keeping material's wettability and mechanical properties...
May 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28527358/improving-the-pharmacokinetics-and-tissue-distribution-of-pyrinezolid-by-self-assembled-polymeric-micelles
#2
Haiyue Long, Xiaoling Li, Zitai Sang, Lan Mei, Tao Yang, Zicheng Li, Liangxue Zhou, Yu Zheng, Gu He, Gang Guo, Zhenling Wang, Yong Deng, Youfu Luo
Antibiotic-resistance by bacteria is a growing global concern within the healthcare field, and it has provided an impetus for continued antimicrobial development. Pyrinezolid (PZ), a novel oxazolidinone compound, can effectively inhibit most gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Though PZ is a promising antimicrobial candidate, the druggability of PZ is limited by its poor water solubility. Therefore, the amphipathic mPEG-PLLA copolymer was used to prepare the pyrinezolid micelles (PZ-M)...
May 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28524719/polyester-based-microdisc-systems-for-sustained-release-of-neuroprotective-phosphine-borane-complexes
#3
David A Janus, Christopher J Lieven, Megan E Crowe, Leonard A Levin
Phosphine-borane complexes are recently developed redox-active drugs that are neuroprotective in models of optic nerve injury and radioprotective in endothelial cells. However, a single dose of these compounds is short-lived, necessitating development of sustained-release formulations of these novel molecules. We screened a library of biodegradable co- and non-block polyester polymer systems for release of incorporated phosphine-borane complexes to evaluate them as drug delivery systems for use in chronic disease...
May 19, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28513477/microtube-array-membrane-bioreactor-promotes-neuronal-differentiation-and-orientation
#4
Sabrina Morelli, Antonella Piscioneri, Simona Salerno, Chien-Chung Chen, Chee Ho Chew, Lidietta Giorno, Enrico Drioli, Loredana De Bartolo
An important challenge in neuronal tissue engineering is to create innovative tools capable of promoting cellular response in terms of neuronal differentiation and neurite orientation that may be used as investigational platforms for studying neurobiological events and neurodegenerative disorders. A novel membrane bioreactor was created to provide a 3D well-controlled microenvironment for neuronal outgrowth. The bioreactor consisted of poly-L-lactic acid highly aligned microtube array (PLLA-MTA) membranes assembled in parallel within a chamber that establish an intraluminal and an extraluminal compartment whose communication occurs through the pores of the MTA membrane walls...
May 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/28510114/fabricating-poly-1-8-octanediol-citrate-elastomer-based-fibrous-mats-via-electrospinning-for-soft-tissue-engineering-scaffold
#5
Lei Zhu, Yuanzheng Zhang, Yali Ji
Poly(1,8-octanediol citrate) (POC) is a recently developed biodegradable crosslinked elastomer that possesses good cytocompatibility and matchable mechanical properties to soft tissues. However, the thermosetting characteristic reveals a big challenge to manufacture its porous scaffold. Herein, POC elastomer was electrospun into fiber mat using poly(L-lactic acid) (PLLA) as a spinnable carrier. The obtained POC/PLLA fiber mats were characterized by scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), uniaxial tensile test, static-water-contact-angle, thermal analysis, in vitro degradation and biocompatibility test...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28498385/polymer-brushes-based-on-plla-b-peo-colloids-for-the-preparation-of-protein-resistant-pla-surfaces
#6
E Mázl Chánová, O Pop-Georgievski, M M Kumorek, O Janoušková, L Machová, D Kubies, F Rypáček
In this study we investigate the formation of protein-resistant polymer surfaces, such as aliphatic polyesters, through the deposition of self-assemblies of amphiphilic poly(l-lactide)-b-poly(ethylene oxide), PLLA-b-PEO, copolymers as stable nanoparticles with a kinetically frozen PLLA core on model PLLA surfaces. The length of the PEO chains in the corona was tuned to achieve polymer brushes capable of preventing protein adsorption on PLA-based biomaterials. The spectroscopic ellipsometry, IR and XPS analysis, contact angle goniometry, and AFM proved that the PEO chains adopted a brush structure and were preferably exposed on the surface...
May 12, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28482571/optimization-and-development-of-maghemite-%C3%AE-fe2o3-filled-poly-l-lactic-acid-plla-thermoplastic-polyurethane-tpu-electrospun-nanofibers-using-taguchi-orthogonal-array-for-tissue-engineering-heart-valve
#7
Ehsan Fallahiarezoudar, Mohaddeseh Ahmadipourroudposht, Ani Idris, Noordin Mohd Yusof
Tissue engineering (TE) is an advanced principle to develop a neotissue that can resemble the original tissue characteristics with the capacity to grow, to repair and to remodel in vivo. This research proposed the optimization and development of nanofiber based scaffold using the new mixture of maghemite (γ-Fe2O3) filled poly-l-lactic acid (PLLA)/thermoplastic polyurethane (TPU) for tissue engineering heart valve (TEHV). The chemical, structural, biological and mechanical properties of nanofiber based scaffold were characterized in terms of morphology, porosity, biocompatibility and mechanical behaviour...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482519/synthesis-of-star-like-hybrid-poss-pdmaema-b-pdla-8-copolymer-and-its-stereocomplex-properties-with-plla
#8
Xiaoshan Fan, Mengya Cao, Xing Zhang, Zibiao Li
Although poly(lactide) (PLA), when used as biomaterials, possesses many good properties, its high hydrophobicity and slow degradation may hinder its applications. In this work, a novel star-like oligomeric silsesquioxane-(poly(2-dimethylaminoethyl methacrylate)-b-poly(d-lactide))8 (POSS-(PDMAEMA-b-PDLA)8) was first synthesized through a three-step procedure that involves Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization of DMAEMA initiated by the macroinitiator POSS-8-CTA, and then conversion of the trithiocarbonated end groups on PDMAEMA arms into hydroxyl groups by a combination of aminolysis and Michael addition followed by controlled ring-opening polymerization of D-LA...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481047/enhanced-chondrogenic-differentiation-of-stem-cells-using-an-optimized-electrospun-nanofibrous-plla-peg-scaffolds-loaded-with-glucosamine
#9
Samaneh Mirzaei, Akbar Karkhaneh, Masoud Soleimani, Abdolreza Ardeshirylajimi, Hasti Seyyed Zonouzi, Hana Hanaee-Ahvaz
Recently, tissue engineering has become one of the most important approaches in medical research for the treatment of injuries and lesions. In the present study, Poly (L-lactide) acid (PLLA), and Poly ethylene glycol (PEG) with different ratios and PEG molecular weights were used in order to produce appropriate nanofibrous scaffolds using the electrospinning technique for cartilage tissue engineering applications. Glucosamine was also incorporated into the polymeric scaffolds to enhance the biological properties...
May 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28480332/label-free-detection-of-small-organic-molecules-by-molecularly-imprinted-polymer-functionalized-thermocouples-toward-in-vivo-applications
#10
Hanne Diliën, Marloes Peeters, Jeroen Royakkers, Jules Harings, Peter Cornelis, Patrick Wagner, Erik Steen Redeker, Craig E Banks, Kasper Eersels, Bart van Grinsven, Thomas J Cleij
Molecularly imprinted polymers (MIPs), synthetic polymeric receptors, have been combined successfully with thermal transducers for the detection of small molecules in recent years. However, up until now they have been combined with planar electrodes which limits their use for in vivo applications. In this work, a new biosensor platform is developed by roll-coating MIP particles onto thermocouples, functionalized with polylactic acid (PLLA). As a first proof-of-principle, MIPs for the neurotransmitter dopamine were incorporated into PLLA-coated thermocouples...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28471065/novel-ultrahigh-molecular-weight-amorphous-plla-bioresorbable-coronary-scaffold-upsized-up-to-0-8-mm-beyond-nominal-diameter-an-oct-and-histopathology-study-in-porcine-coronary-artery-model
#11
Pawel Gasior, Yanping Cheng, Edward A Estrada, Jenn McGregor, Kamal Ramzipoor, Chang Lee, Gerard B Conditt, Serge D Rousselle, Juan F Granada, Grzegorz L Kaluza
OBJECTIVES: The aim of the study was to evaluate the biomechanical properties and healing pattern of novel sirolimus-eluting, ultrahigh molecular weight amorphous poly-L-lactic acid bioresorbable scaffolds (S-BRS) that have been postdilated by 0.55 and 0.8 mm beyond the nominal diameters within the pressure-diameter compliance chart range. BACKGROUND: Due to the inherent limitations of bioabsorbable polymeric materials, overexpansion/upsizing may be very limited for some BRS such as the benchmark Absorb BVS...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28470445/ftir-microscopy-contribution-for-comprehension-of-degradation-mechanisms-in-pla-based-implantable-medical-devices
#12
Adrien Leroy, Sofia Ribeiro, Carole Grossiord, Antoine Alves, Robert H Vestberg, Vincent Salles, Céline Brunon, Kerstin Gritsch, Brigitte Grosgogeat, Yves Bayon
The integration and evolution of implantable medical devices made of bioresorbable polymers and used for temporary biomedical applications are crucial criteria in the success of a therapy and means of follow-up after implantation are needed. The objective of this work is to develop and evaluate a method based on microscopic Fourier Transform InfraRed spectroscopy (FTIR) mappings to monitor the degradation of such polymers on tissue explant sections, after implantation. This technique provided information on their location and on both their composition and crystallinity, which is directly linked to their state of degradation induced predominantly by chain scissions...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28466854/increase-the-elongation-at-break-of-poly-lactic-acid-composites-for-use-in-food-packaging-films
#13
Ahmed M El-Hadi
Poly (3-hydroxy butyrate) (PHB), cellulose nano crystal (CNC) and a plasticizer (TBC) are mixed together with PLLA with the aim to increase the elongation at break for use in the food packing sector. Spherical (CNC) and fibril nano crystal (CNF) were prepared by hydrolysis of microcrystalline cellulose (MCC) in distilled water, and then stirred using a magnetic stirrer for 15 days and ultrasonic treatment without using any acids as green method. The morphology, thermal, and mechanical properties were studied using POM, DSC, WAXD, SEM and tensile testing, respectively...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446016/biodegradation-and-biocompatibility-of-poly-l-lactic-acid-implantable-mesh
#14
Sang-Don Yoon, Young-Sam Kwon, Kyu-Sung Lee
PURPOSE: The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. METHODS: PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated. RESULTS: The weight and tensile strength of the PLLA prosthesis was stable for 180 days. In addition, the surface of the PLLA mesh was not digested under in vitro or in vivo conditions as determined by scanning electron microscope...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28418236/novel-approach-of-using-near-infrared-responsive-pegylated-gold-nanorod-coated-poly-l-lactide-microneedles-to-enhance-the-antitumor-efficiency-of-docetaxel-loaded-mpeg-pdlla-micelles-for-treating-an-a431-tumor
#15
Ying Hao, MingLing Dong, TaoYe Zhang, JinRong Peng, YanPeng Jia, YiPing Cao, ZhiYong Qian
The combination of chemotherapy and photothermal therapy (PTT) plays a significant role in synergistic tumor therapy. However, a high dosage of chemotherapy drugs or photothermal agents may cause series side effects. To overcome these challenges, we designed a near-infrared (NIR) responsive PEGylated gold nanorod (GNR-PEG) coated poly(l-lactide) microneedle (PLLA MN) system (GNR-PEG@MN) to enhance antitumor efficiency of docetaxel-loaded MPEG-PDLLA (MPEG-PDLLA-DTX) micelles for treating an A431 tumor. The as-made GNR-PEG@MNs contained only 31...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28415912/a-method-for-the-immunohistochemical-identification-and-localization-of-osterix-in-periosteum-wrapped-constructs-for-tissue-engineering-of-bone
#16
Phillip McClellan, Robin Jacquet, Qing Yu, William J Landis
A novel immunohistochemistry (IHC) approach has been developed to label and localize osterix, a bone-specific transcription factor, within formalin-fixed, paraffin-embedded, tissue-engineered constructs uniquely containing synthetic polymers and human periosteal tissue. Generally, such specimens consisting in part of polymeric materials and mineral are particularly difficult for IHC identification of proteins. Samples here were fabricated from human periosteum, electrospun poly-l-lactic acid (PLLA) nanofibers, and polycaprolactone/poly-l-lactic acid (PCL/PLLA, 75/25) scaffolds and harvested following 10 weeks of implantation in athymic mice...
April 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28415547/effect-of-polymer-degradation-on-prolonged-release-of-paclitaxel-from-filomicelles-of-polylactide-poly-ethylene-glycol-block-copolymers
#17
Katarzyna Jelonek, Suming Li, Janusz Kasperczyk, Xiaohan Wu, Arkadiusz Orchel
Paclitaxel is one of the most efficient anticancer agents, but the conventional dosage formulations cause many side effects. PLA-PEG filomicelles are promising carriers of paclitaxel because high loading capacity and long term release can be achieved. Slow release of cytostatic drugs is very advantageous due to prolonged exposure of tumor cells to cytostatic over multiple cell cycles. The aim of this study was to evaluate the potential of bioresorbable PLA-PEG filomicelles for prolonged delivery of paclitaxel...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415542/bladder-smooth-muscle-cells-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-poly-l-lactic-acid-scaffold-promote-bladder-regeneration-in-a-canine-model
#18
Nasser Shakhssalim, Masoud Soleimani, Mohammad M Dehghan, Javad Rasouli, Masoud Taghizadeh-Jahed, Peyman M Torbati, Mohammad Naji
Engineering of urinary bladder has been the focus of numerous studies in recent decade. Novel biomaterials, innovative fabrication methods and various modification processes of scaffolds are the critical issues to find supportive matrices. Supportive characteristics of electrospun PCL/PLLA nano-scaffold for bladder augmentation in canine model and the role of bladder cells in regeneration process were appraised. Electrospun PCL/PLLA was fabricated by co-electrospinning of PCL and PLLA. Bladder cells were isolated and transduced with lentiviral particles encoding eGFP and JRed proteins...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415520/tuneable-hydrolytic-degradation-of-poly-l-lactide-scaffolds-triggered-by-zno-nanoparticles
#19
Erlantz Lizundia, Paula Mateos, José Luis Vilas
In this work we fabricate porous PLLA and PLLA/ZnO scaffolds with porosities ranging from 10 to 90% and average pore diameter of 125-250μm by solvent casting/particulate leaching method. The structural evolution of PLLA/ZnO scaffolds during their in vitro degradation in phosphate buffered saline (PBS) at physiological pH (7.4) has been studied as a function of porosity and obtained results were compared to plain PLLA scaffolds. The changes induced upon the hydrolytic degradation of scaffolds have been explored by measuring the pH changes of the medium, the mass loss, thermal transitions, crystalline structure, thermal stability and the morphological changes...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415467/poly-l-lactic-acid-and-polyurethane-nanofibers-fabricated-by-solution-blow-spinning-as-potential-substrates-for-cardiac-cell-culture
#20
Ewelina Tomecka, Michal Wojasinski, Elzbieta Jastrzebska, Michal Chudy, Tomasz Ciach, Zbigniew Brzozka
This paper presents a comparison and evaluation of cardiac cell proliferation on poly(l-lactic acid) (PLLA) and polyurethane (PU) nanofibrous mats fabricated by solution blow spinning (SBS). Three different cardiac cell lines: rat cardiomyoblasts (H9C2 line), human (HCM) and rat cardiomyocytes (RCM) were used for experiments. Cell morphology, orientation and proliferation were investigated on non-modified and protein-modified (fibronectin, collagen, gelatin, laminin, poly-l-lysine) surfaces of both types of nanofibers...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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