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https://www.readbyqxmd.com/read/28230244/topical-anaesthetics-for-pain-control-during-repair-of-dermal-laceration
#1
REVIEW
Baraa O Tayeb, Anthony Eidelman, Cristy L Eidelman, Ewan D McNicol, Daniel B Carr
BACKGROUND: Topical local anaesthetics provide effective analgesia for patients undergoing numerous superficial procedures, including repair of dermal lacerations. The need for cocaine in topical anaesthetic formulations has been questioned because of concern about adverse effects, thus novel preparations of cocaine-free anaesthetics have been developed. This review was originally published in 2011 and has been updated in 2017. OBJECTIVES: To assess whether benefits of non-invasive topical anaesthetic application occur at the expense of decreased analgesic efficacy...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28229493/issues-with-monitoring-the-safety-of-psychoactive-products-under-a-legal-regulated-market-for-new-psychoactive-substances-legal-highs-in-new-zealand
#2
Marta Rychert, Chris Wilkins, Karen Witten
INTRODUCTION: New Zealand's Psychoactive Substances Act (2013) established the world's first regulated market for 'low risk' psychoactive products ('legal highs'). Under an interim PSA regime, 47 existing products were permitted to be continued to be sold. AIM: To explore issues with the implementation of regulatory systems to monitor the safety of products on the legal market under the interim Psychoactive Substances Act regime. METHODS: Semi-structured interviews with 30 key stakeholders, including industry, government agency, health and drug service professionals were conducted, transcribed and analysed thematically...
February 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28214006/-conduct-of-epidemiologic-studies-in-french-cancer-survivors-methods-difficulties-encountered-and-solutions-provided-lessons-learned-from-the-simonal-study-on-long-term-toxicities-after-non-hodgkin-lymphoma-treatment
#3
Sabine Anthony, Pierre Hebel, André Garrel, Vanina Oliveri, Catherine Thieblemont, Vincent Ribrag, Hervé Tilly, Corinne Haioun, René-Olivier Casasnovas, Franck Morschhauser, Pierre Feugier, Richard Delarue, Loic Ysebaert, Catherine Sebban, Florence Broussais, Gandhi Damaj, Virginie Nerich, Jean-Philippe Jais, Gilles Salles, Michel Henry-Amar, Nicolas Mounier
INTRODUCTION: Since the introduction of targeted therapies, specific lymphoma mortality has decreased. Possible long-term toxicities, however, are not known yet. This article describes the implementation of the SIMONAL study that investigates the hypothesis of an overconsumption of care after lymphoma treatment with a 10-year follow-up. METHODS: After the mandatory regulatory steps (CCTIRS and CNIL) the vital status and address of 5247 patients treated in 131 French centers were retrieved using a secure web portal, in order to send a quality of life after lymphoma questionnaire...
February 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28210235/clinical-case-studies-in-psychoanalytic-and-psychodynamic-treatment
#4
REVIEW
Jochem Willemsen, Elena Della Rosa, Sue Kegerreis
This manuscript provides a review of the clinical case study within the field of psychoanalytic and psychodynamic treatment. The method has been contested for methodological reasons and because it would contribute to theoretical pluralism in the field. We summarize how the case study method is being applied in different schools of psychoanalysis, and we clarify the unique strengths of this method and areas for improvement. Finally, based on the literature and on our own experience with case study research, we come to formulate nine guidelines for future case study authors: (1) basic information to include, (2) clarification of the motivation to select a particular patient, (3) information about informed consent and disguise, (4) patient background and context of referral or self-referral, (5) patient's narrative, therapist's observations and interpretations, (6) interpretative heuristics, (7) reflexivity and counter-transference, (8) leaving room for interpretation, and (9) answering the research question, and comparison with other cases...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28206888/evidence-based-clinical-practice-guideline-for-the-use-of-pit-and-fissure-sealants
#5
(no author information available yet)
BACKGROUND: This article presents evidence-based clinical recommendations for the use of pit-and-fissure sealants on the occlusal surfaces of primary and permanent molars in children and adolescents. A guideline panel convened by the American Dental Association (ADA) Council on Scientific Affairs and the American Academy of Pediatric Dentistry conducted a systematic review and formulated recommendations to address clinical questions in relation to the efficacy, retention, and potential side effects of sealants to prevent dental caries; their efficacy compared with fluoride varnishes; and a head-to-head comparison of the different types of sealant material used to prevent caries on pits-and-fissures of occlusal surfaces...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28203364/tiotropium-formulations-and-safety-a-network-meta-analysis
#6
Mario Cazzola, Luigino Calzetta, Paola Rogliani, Maria Gabriella Matera
Tiotropium is now delivered via two different inhaler devices: the original Handihaler 18 μg once daily, which uses a powder formulation; and the newer Respimat Soft Mist Inhaler (SMI) 5 μg once daily. It has been questioned whether the two devices can be assumed to have the same safety profile, although the TIOSPIR trial showed that tiotropium when administered via Respimat SMI 5 μg is not less safe than Handihaler 18 μg. Therefore, we have carried out a safety evaluation of tiotropium Handihaler 18 µg versus tiotropium Respimat SMI 5 µg and 2...
January 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28202034/transcriptomic-signatures-shaped-by-cell-proportions-shed-light-on-comparative-developmental-biology
#7
Sophie Pantalacci, Laurent Guéguen, Coraline Petit, Anne Lambert, Renata Peterkovà, Marie Sémon
BACKGROUND: Comparative transcriptomics can answer many questions in developmental and evolutionary developmental biology. Most transcriptomic studies start by showing global patterns of variation in transcriptomes that differ between species or organs through developmental time. However, little is known about the kinds of expression differences that shape these patterns. RESULTS: We compared transcriptomes during the development of two morphologically distinct serial organs, the upper and lower first molars of the mouse...
February 15, 2017: Genome Biology
https://www.readbyqxmd.com/read/28188945/assessment-of-clinical-teachers-professionalism-in-iran-from-residents-and-fellowships-perspective
#8
Sima Garshasbi, Hamidollah Bahador, Nahid Fakhraei, Abolfazl Farbod, Maryam Mohammadi, Soleiman Ahmady, Seyed Hassan Emami Razavi
In the present study, professional conduct of clinical teachers in Tehran University of Medical Sciences in Iran was assessed by their residents (n=292) and fellowships (n=48) using a standard questioner called self-reported measurement equipment. This evaluation was a descriptive cross-sectional study. Professionalism was questioned in four domains including clinical teacher-patient, clinical teacher-student, inter-professional and clinical teacher-self relationships. Accordingly, mean scores of the teachers in cases of clinical teacher-patient; clinical teacher-student, inter-professional (teamwork) and clinical teacher-self relations were 61%, 62...
January 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28188665/memory-for-relations-in-the-short-term-and-the-long-term-after-medial-temporal-lobe-damage
#9
Larry R Squire
A central idea about the organization of declarative memory and the function of the hippocampus is that the hippocampus provides for the coding of relationships between items. A question arises whether this idea refers to the process of forming long-term memory or whether, as some studies have suggested, memory for relations might depend on the hippocampus even at short retention intervals and even when the task falls within the province of short-term (working) memory. The latter formulation appears to place the operation of relational memory into conflict with the idea that working memory is independent of medial temporal lobe (MTL) structures...
February 11, 2017: Hippocampus
https://www.readbyqxmd.com/read/28188124/commencing-and-persisting-with-a-web-based-cognitive-behavioral-intervention-for-insomnia-a-qualitative-study-of-treatment-completers
#10
Charles Chan, Stacey West, Nick Glozier
BACKGROUND: Computerized cognitive behavioral therapy for insomnia (CCBT-I) has a growing evidence base as a stand-alone intervention, but it is less clear what factors may limit its acceptability and feasibility when combined with clinical care. OBJECTIVE: The purpose of this study was to explore barriers and facilitators to use of an adjunctive CCBT-I program among depressed patients in a psychiatric clinic by using both quantitative and qualitative approaches...
February 10, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28181818/recommendations-for-the-management-of-adrenal-incidentalomas-what-is-pertinent-for-radiologists
#11
Anju Sahdev
Adrenal incidentalomas are unsuspected, asymptomatic adrenal masses detected on imaging. Most are non-functioning benign adrenocortical adenomas, but can represent other benign lesions or lesions requiring therapeutic intervention including adrenocortical carcinoma, pheochromocytoma, hormone-producing adenoma or metastasis. This review summarises and highlights radiological recommendations within the recently issued guidelines for the management of adrenal incidentalomas from European Society of Endocrinology Clinical Practice in collaboration with European Network for Study of Adrenal Tumours...
February 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28168697/the-death-instinct-and-the-mental-dimension-beyond-the-pleasure-principle-in-the-works-of-spielrein-and-freud
#12
Fátima Caropreso
In 'Destruction as Cause of Come-into-being', Spielrein argues for the need of postulating the existence of a death instinct in mental functioning. The idea that she thus anticipated the concept of death instinct Freud introduced in 1920 is often found in psychoanalytic literature. But the specific meaning of Spielrein's hypothesis is seldom discussed, as well as the extent to which she anticipated Freud's concept. In fact, there are important differences between their views. Besides, a closer analysis of Spielrein's text reveals other ideas that come close to fundamental aspects of Freud's theories from 1920 onwards, particularly the assumption of a more primordial mental functioning than the one regulated by the pleasure principle...
February 7, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28167494/practising-evidence-based-medicine-ebm-a-descriptive-analysis-of-medical-students-whole-task-ebm-assignments
#13
Lauren A Maggio, Nicole Capdarest-Arest
Researchers have suggested whole-task learning activities to practice and teach evidence-based medicine (EBM); however, limited description exists of their use in EBM curricula. This article describes medical students' execution of a whole-task EBM assignment and characterises themes emerging from assignment submissions. Between 2013 and 2015, Stanford University's paediatric clerkship students completed a whole-task EBM assignment based on a patient encounter. The assignment captured students' efforts to perform all EBM steps and describe their patient scenario and future knowledge needs strategies...
February 6, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28164864/towards-a-unified-model-of-neutrino-nucleus-reactions-for-neutrino-oscillation-experiments
#14
Satoshi Nakamura, Hiroyuki Kamano, Yoshinari Hayato, Masanori Hirai, Wataru Horiuchi, Shunzo Kumano, Tomoya Murata, Koichi Saito, Makoto Sakuda, Toru Sato, Yasuyuki Suzuki
A precise description of neutrino-nucleus reactions will play a key role in addressing fundamental questions such as the leptonic CP violation and the neutrino mass hierarchy through analyzing data from next-generation neutrino oscillation experiments. The neutrino energy relevant to the neutrino-nucleus reactions spans a broad range and, accordingly, the dominant reaction mechanism varies across the energy region from quasi-elastic scattering through nucleon resonance excitations to deep inelastic scattering...
February 6, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28159393/what-are-the-blood-lead-levels-of-children-living-in-latin-america-and-the-caribbean
#15
REVIEW
Kelly Polido Kaneshiro Olympio, Cláudia Gaudência Gonçalves, Fernanda Junqueira Salles, Ana Paula Sacone da Silva Ferreira, Agnes Silva Soares, Marília Afonso Rabelo Buzalaf, Maria Regina Alves Cardoso, Etelvino José Henriques Bechara
INTRODUCTION: Information on the prevalence of lead exposure is essential to formulate efficient public health policies. Developed countries have implemented successful public policies for the prevention and control of lead poisoning. In the United States, Canada, Japan and the European Union, for instance, periodically repeated prevalence studies show that blood lead levels (BLLs) in children have decreased overall. Although BLL of Latino children in the U.S. have also dropped in recent years, the geometric mean remains higher than that of white children...
February 1, 2017: Environment International
https://www.readbyqxmd.com/read/28146297/development-of-a-patient-centered-outcome-measure-for-emergency-department-asthma-patients
#16
Margaret E Samuels-Kalow, Karin V Rhodes, Mira Henien, Emily Hardy, Thomas Moore, Felicia Wong, Carlos A Camargo, Carolyn T Rizzo, Cynthia Mollen
BACKGROUND: Measuring outcomes of emergency care is of key importance, but current metrics, such as 72-hour return visit rates, are subject to ascertainment bias, incentivize over-testing and over-treatment at initial visit, and do not reflect the full burden of disease and morbidity experienced at home following ED care. There is increasing emphasis on including patient-reported outcomes, but the existing patient-reported measures have limited applicability to emergency care. OBJECTIVE: To identify concepts for inclusion in a patient-reported outcome measure for ED care, and assess differences in potential concepts by health literacy...
February 1, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28143696/management-of-children-with-chronic-wet-cough-and-protracted-bacterial-bronchitis-chest-guideline-and-expert-panel-report
#17
Anne B Chang, John J Oppenheimer, Miles Weinberger, Bruce K Rubin, Cameron C Grant, Kelly Weir, Richard S Irwin
BACKGROUND: Wet or productive cough is common in children with chronic cough. We formulated recommendations based on systematic reviews relating to the management of chronic wet cough in children (aged ≤14-years) based on key questions (KQ1)-how effective are antibiotics in improving the resolution of cough? If so, what and for how long? and; (KQ2)-when should children be referred for further investigations? METHODS: We used the CHEST expert cough panel's protocol for the systematic reviews and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework...
January 28, 2017: Chest
https://www.readbyqxmd.com/read/28138368/investigating-structure-and-dynamics-of-proteins-in-amorphous-phases-using-neutron-scattering
#18
REVIEW
Maria Monica Castellanos, Arnold McAuley, Joseph E Curtis
In order to increase shelf life and minimize aggregation during storage, many biotherapeutic drugs are formulated and stored as either frozen solutions or lyophilized powders. However, characterizing amorphous solids can be challenging with the commonly available set of biophysical measurements used for proteins in liquid solutions. Therefore, some questions remain regarding the structure of the active pharmaceutical ingredient during freezing and drying of the drug product and the molecular role of excipients...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28138347/propelling-the-paradigm-shift-from-reductionism-to-systems-nutrition
#19
EDITORIAL
Jim Kaput, Giuditta Perozzi, Marijana Radonjic, Fabio Virgili
The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, cell, and microbial models have been extensively used to address questions that could not be pursued experimentally in humans, posing an additional level of complexity in translation of the results to healthy and diseased metabolism. The past few decades have witnessed a surge in development of increasingly sensitive molecular techniques and bioinformatic tools for storing, managing, and analyzing increasingly large datasets...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28131717/aptamer-functionalized-hybrid-nanoparticle-for-the-treatment-of-breast-cancer
#20
David Powell, Sruti Chandra, Kyra Dodson, Farhana Shaheen, Kylar Wilt, Shubha Ireland, Muniruzzaman Syed, Srikanta Dash, Thomas Wiese, Tarun Mandal, Anup Kundu
PURPOSE: Resistance to chemotherapeutic agents such as doxorubicin is a major reason for cancer treatment failure. At present the treatment option for metastatic breast cancer is very poor. Therefore, development of an effective therapeutic strategy to circumvent MDR of metastatic breast cancer is highly anticipated. The MDR of metastatic breast cancer cells was accompanied with the overexpression of P-gp transporter. Even though the overexpression of P-gp could be minimized by silencing with siRNA, the question is how they can be selectively targeted to the cancer cells...
January 25, 2017: European Journal of Pharmaceutics and Biopharmaceutics
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