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https://www.readbyqxmd.com/read/28521375/a-genetic-marker-associated-with-shoulder-dislocation
#1
Stuart Kim, John P Kleimeyer, Marwa A Ahmed, Andy L Avins, Michael Fredericson, Jason L Dragoo, John P A Ioannidis
Shoulder dislocations are common shoulder injuries associated with athletic activity in contact sports, such as football, rugby, wrestling, and hockey. Identifying genetic loci associated with shoulder dislocation could shed light on underlying mechanisms for injury and identify predictive genetic markers. To identify DNA polymorphisms associated with shoulder dislocation, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 662 cases of shoulder dislocation and 82 602 controls from the European ancestry group...
May 18, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28521056/ethnic-minority-status-age-at-immigration-and-psychosis-risk-in-rural-environments-evidence-from-the-sepea-study
#2
James B Kirkbride, Yasir Hameed, Konstantinos Ioannidis, Gayatri Ankireddypalli, Carolyn M Crane, Mukhtar Nasir, Nikolett Kabacs, Antonio Metastasio, Oliver Jenkins, Ashkan Espandian, Styliani Spyridi, Danica Ralevic, Suneetha Siddabattuni, Ben Walden, Adewale Adeoye, Jesus Perez, Peter B Jones
Objective: Several ethnic minority groups experience elevated rates of first-episode psychosis (FEP), but most studies have been conducted in urban settings. We investigated whether incidence varied by ethnicity, generation status, and age-at-immigration in a diverse, mixed rural, and urban setting. Method: We identified 687 people, 16-35 years, with an ICD-10 diagnosis of FEP, presenting to Early Intervention Psychosis services in the East of England over 2 million person-years...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28482362/two-genetic-loci-associated-with-medial-collateral-ligament-injury
#3
Andrew K Roos, Andy L Avins, Marwa A Ahmed, John P Kleimeyer, Thomas R Roos, Michael Fredericson, John P A Ioannidis, Jason L Dragoo, Stuart Kim
Medial collateral ligament (MCL) injuries are a common knee injury, especially in competitive athletes. Identifying genetic loci associated with MCL injury could shed light on its etiology. A genome-wide association screen was performed using data from the Research Program in Genes, Environment and Health (RPGEH) including 1 572 cases of MCL injury and 100 931 controls. 2 SNPs (rs80351309 and rs6083471) showed an association with MCL injury at genome-wide significance (p<5×10(-8)) with moderate effects (odds ratios=2...
May 8, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28459974/defending-biomedical-science-in-an-era-of-threatened-funding
#4
John P A Ioannidis
No abstract text is available yet for this article.
May 1, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28445470/the-credibility-crisis-in-research-can-economics-tools-help
#5
Thomas Gall, John P A Ioannidis, Zacharias Maniadis
The issue of nonreplicable evidence has attracted considerable attention across biomedical and other sciences. This concern is accompanied by an increasing interest in reforming research incentives and practices. How to optimally perform these reforms is a scientific problem in itself, and economics has several scientific methods that can help evaluate research reforms. Here, we review these methods and show their potential. Prominent among them are mathematical modeling and laboratory experiments that constitute affordable ways to approximate the effects of policies with wide-ranging implications...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28435099/a-meta-analysis-but-not-a-systematic-review-an-evaluation-of-the-global-bmi-mortality-collaboration
#6
Katherine M Flegal, John P A Ioannidis
Meta-analyses of individual participant data (MIPDs) offer many advantages and are considered the highest level of evidence. However, MIPDs can be seriously compromised when they are not solidly founded upon a systematic review. These data-intensive collaborative projects may be led by experts who already have deep knowledge of the literature in the field and of the results of published studies and how these results vary based on different analytical approaches. If investigators tailor the searches, eligibility criteria and analysis plan of the MIPD, they run the risk of reaching foregone conclusions...
April 20, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28419203/selective-cutoff-reporting-in-studies-of-diagnostic-test-accuracy-a-comparison-of-conventional-and-individual-patient-data-meta-analyses-of-the-patient-health-questionnaire-9-depression-screening-tool
#7
Brooke Levis, Andrea Benedetti, Alexander W Levis, John P A Ioannidis, Ian Shrier, Pim Cuijpers, Simon Gilbody, Lorie A Kloda, Dean McMillan, Scott B Patten, Russell J Steele, Roy C Ziegelstein, Charles H Bombardier, Flavia de Lima Osório, Jesse R Fann, Dwenda Gjerdingen, Femke Lamers, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Juwita Shaaban, Lesley Stafford, Henk C P M van Weert, Mary A Whooley, Linda S Williams, Karin A Wittkampf, Albert S Yeung, Brett D Thombs
In studies of diagnostic test accuracy, authors sometimes report results only for a range of cutoff points around data-driven "optimal" cutoffs. We assessed selective cutoff reporting in studies of the diagnostic accuracy of the Patient Health Questionnaire-9 (PHQ-9) depression screening tool. We compared conventional meta-analysis of published results only with individual-patient-data meta-analysis of results derived from all cutoff points, using data from 13 of 16 studies published during 2004-2009 that were included in a published conventional meta-analysis...
May 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28411080/a-meta-analysis-of-individual-participant-data-constructed-to-align-with-prior-expert-views-comments-on-bhupathiraju-et%C3%A2-al
#8
Katherine M Flegal, John P A Ioannidis
No abstract text is available yet for this article.
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28407061/lifetime-abuse-and-perceived-social-support-among-the-elderly-a-study-from-seven-european-countries
#9
Bahareh Eslami, Mirko Di Rosa, Henrique Barros, Mindaugas Stankunas, Francisco Torres-Gonzalez, Elisabeth Ioannidi-Kapolou, Jutta Lindert, Maria Gabriella Melchiorre
Being a victim of abuse during one's life course may affect social relations in later life. The aims of this study were to: (i) examine the association between lifetime abuse and perceived social support and (ii) identify correlates of perceived social support among older persons living in seven European countries. A sample of 4467 women and men aged 60-84 years living in Germany, Greece, Italy, Lithuania, Portugal, Spain and Sweden was collected through a cross-sectional population-based study. Abuse (psychological, physical, sexual, financial and injury) was assessed through interviews or interviews/self-response questionnaire based on the Conflict Tactics Scale-2 and the UK study on elder abuse...
April 11, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28397612/adolescent-friendships-predict-later-resilient-functioning-across-psychosocial-domains-in-a-healthy-community-cohort
#10
A-L van Harmelen, R A Kievit, K Ioannidis, S Neufeld, P B Jones, E Bullmore, R Dolan, P Fonagy, I Goodyer
BACKGROUND: Adolescence is a key time period for the emergence of psychosocial and mental health difficulties. To promote adolescent adaptive ('resilient') psychosocial functioning (PSF), appropriate conceptualisation and quantification of such functioning and its predictors is a crucial first step. Here, we quantify resilient functioning as the degree to which an individual functions better or worse than expected given their self-reported childhood family experiences, and relate this to adolescent family and friendship support...
April 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28380001/changes-in-circulating-microrna-levels-can-be-identified-as-early-as-day-8-of-pregnancy-in-cattle
#11
Jason Ioannidis, F Xavier Donadeu
Poor reproductive performance remains a major issue in the dairy industry, with low conception rates having a significant impact on milk production through extended calving intervals. A major limiting factor is the lack of reliable methods for early pregnancy diagnosis. Identification of animals within a herd that fail to conceive within 3 weeks after insemination would allow early re-insemination and shorten calving intervals. In a previous study, we found an increase in plasma miR-26a levels in Day 16-pregnant relative to non-pregnant heifers, however changes in miRNA levels that early during pregnancy were very small which likely prevented the identification of robust biomarkers...
2017: PloS One
https://www.readbyqxmd.com/read/28368475/the-adequate-corpus-luteum-mir-96-promotes-luteal-cell-survival-and-progesterone-production
#12
Bushra T Mohammed, Sadanand D Sontakke, Jason Ioannidis, W Colin Duncan, F Xavier Donadeu
Context: Inadequate progesterone production from the corpus luteum is associated with pregnancy loss. Data available in model species suggest important roles of miRNAs in luteal development and maintenance. Objective: To comprehensively investigate the involvement of miRNAs during the ovarian follicle-luteal transition. Design: The effects of specific miRNAs on survival and steroid production by human luteinized granulosa cells (hLGCs) were tested using specific miRNA inhibitors...
March 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28365627/corrigendum-headache-in-an-hiv-positive-patient-diagnostic-challenges-and-approach-to-treatment
#13
Andrew Creamer, Stefanos Ioannidis, Thomas Wilhelm, Tabitha Mahungu, Marc Lipman
No abstract text is available yet for this article.
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28358823/genome-wide-association-screens-for-achilles-tendon-and-acl-tears-and-tendinopathy
#14
Stuart K Kim, Thomas R Roos, Andrew K Roos, John P Kleimeyer, Marwa A Ahmed, Gabrielle T Goodlin, Michael Fredericson, John P A Ioannidis, Andrew L Avins, Jason L Dragoo
Achilles tendinopathy or rupture and anterior cruciate ligament (ACL) rupture are substantial injuries affecting athletes, associated with delayed recovery or inability to return to competition. To identify genetic markers that might be used to predict risk for these injuries, we performed genome-wide association screens for these injuries using data from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort consisting of 102,979 individuals. We did not find any single nucleotide polymorphisms (SNPs) associated with either of these injuries with a p-value that was genome-wide significant (p<5x10-8)...
2017: PloS One
https://www.readbyqxmd.com/read/28357835/identification-of-world-health-organisation-ship-s-medicine-chest-contents-by-anatomical-therapeutic-chemical-atc-classification-codes
#15
Seyed Khorsow Tayebati, Giulio Nittari, Syed Sarosh Mahdi, Nicholas Ioannidis, Fabio Sibilio, Francesco Amenta
BACKGROUND: Ships should carry mandatory given amounts of medicinal products and basic first aid items, collectively known as the ship's medicine chest. Type and quantities of these products/items are suggested by the World Health Organisation (WHO) and regulated by individual flag states. In countries that lack national legislation, it is assumed that ships should follow WHO indications. An objective difficulty mainly involving vessels of international long-haul routes could be to recognise medicinal compounds obtained in other countries for replacing products used or expired...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28321561/ethics-and-epistemology-in-big-data-research
#16
Wendy Lipworth, Paul H Mason, Ian Kerridge, John P A Ioannidis
Biomedical innovation and translation are increasingly emphasizing research using "big data." The hope is that big data methods will both speed up research and make its results more applicable to "real-world" patients and health services. While big data research has been embraced by scientists, politicians, industry, and the public, numerous ethical, organizational, and technical/methodological concerns have also been raised. With respect to technical and methodological concerns, there is a view that these will be resolved through sophisticated information technologies, predictive algorithms, and data analysis techniques...
March 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28320937/meta-assessment-of-bias-in-science
#17
Daniele Fanelli, Rodrigo Costas, John P A Ioannidis
Numerous biases are believed to affect the scientific literature, but their actual prevalence across disciplines is unknown. To gain a comprehensive picture of the potential imprint of bias in science, we probed for the most commonly postulated bias-related patterns and risk factors, in a large random sample of meta-analyses taken from all disciplines. The magnitude of these biases varied widely across fields and was overall relatively small. However, we consistently observed a significant risk of small, early, and highly cited studies to overestimate effects and of studies not published in peer-reviewed journals to underestimate them...
April 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28306144/exclusion-of-elderly-people-from-randomized-clinical-trials-of-drugs-for-ischemic-heart-disease
#18
Florence T Bourgeois, Liat Orenstein, Sarita Ballakur, Kenneth D Mandl, John P A Ioannidis
OBJECTIVES: To measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease (IHD) and describe the characteristics of these trials. DESIGN: Cross-sectional analysis. SETTING: Interventional clinical trials studying a drug intervention for IHD that started in 2006 and after were identified in ClinicalTrials.gov. Data were extracted on study features, including age-based inclusion criteria...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28298413/the-reproducibility-wars-successful-unsuccessful-uninterpretable-exact-conceptual-triangulated-contested-replication
#19
John P A Ioannidis
No abstract text is available yet for this article.
March 15, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28286545/erratum-to-iroa-international-register-of-open-abdomen-preliminary-results
#20
Federico Coccolini, Giulia Montori, Marco Ceresoli, Fausto Catena, Rao Ivatury, Michael Sugrue, Massimo Sartelli, Paola Fugazzola, Davide Corbella, Francesco Salvetti, Ionut Negoi, Monica Zese, Savino Occhionorelli, Stefano Maccatrozzo, Sergei Shlyapnikov, Christian Galatioto, Massimo Chiarugi, Zaza Demetrashvili, Daniele Dondossola, Yovcho Yovtchev, Orestis Ioannidis, Giuseppe Novelli, Mirco Nacoti, Desmond Khor, Kenji Inaba, Demetrios Demetriades, Torsten Kaussen, Asri Che Jusoh, Wagih Ghannam, Boris Sakakushev, Ohad Guetta, Agron Dogjani, Stefano Costa, Sandeep Singh, Dimitrios Damaskos, Arda Isik, Kuo-Ching Yuan, Francesco Trotta, Stefano Rausei, Aleix Martinez-Perez, Giovanni Bellanova, Vinicius Cordeiro Fonseca, Fernando Hernández, Athanasios Marinis, Wellington Fernandes, Martha Quiodettis, Miklosh Bala, Andras Vereczkei, Rafael L Curado, Gustavo Pereira Fraga, Bruno M Pereira, Mahir Gachabayov, Guillermo Perez Chagerben, Miguel Leon Arellano, Sefa Ozyazici, Gianluca Costa, Tugan Tezcaner, Luca Ansaloni
[This corrects the article DOI: 10.1186/s13017-017-0123-8.].
2017: World Journal of Emergency Surgery: WJES
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