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https://www.readbyqxmd.com/read/29440066/data-sharing-and-reanalysis-of-randomized-controlled-trials-in-leading-biomedical-journals-with-a-full-data-sharing-policy-survey-of-studies-published-in-the-bmj-and-plos-medicine
#1
Florian Naudet, Charlotte Sakarovitch, Perrine Janiaud, Ioana Cristea, Daniele Fanelli, David Moher, John P A Ioannidis
OBJECTIVES: To explore the effectiveness of data sharing by randomized controlled trials (RCTs) in journals with a full data sharing policy and to describe potential difficulties encountered in the process of performing reanalyses of the primary outcomes. DESIGN: Survey of published RCTs. SETTING: PubMed/Medline. ELIGIBILITY CRITERIA: RCTs that had been submitted and published by The BMJ and PLOS Medicine subsequent to the adoption of data sharing policies by these journals...
February 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29435923/profiling-of-micrornas-in-the%C3%A2-biofluids-of-livestock-species
#2
Jason Ioannidis, Judith Risse, F Xavier Donadeu
The value of circulating microRNAs (miRNAs) as noninvasive biomarkers of human disease has been extensively demonstrated. Significant potential also exists in other species, particularly in relation to control of veterinary diseases and selection/monitoring of production traits in livestock. Although robust protocols have been developed for miRNA profiling of human biofluids, significant optimization may be required before these can be applied to other species. In this chapter, we describe protocols for small-RNA sequencing and RT-qPCR analyses of plasma samples from livestock species...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29432860/larger-effect-sizes-in-non-randomized-studies-are-associated-with-higher-rates-of-ema-licensing-approval
#3
Benjamin Djulbegovic, Paul Glasziou, Farina A Klocksieben, Tea Reljic, Magali VanDenBergh, Rahul Mhaskar, John P A Ioannidis, Iain Chalmers
OBJECTIVES: Evaluate how often the European Medicines Agency (EMA) has authorized drugs based on non-randomized studies and whether there is an association between treatment effects and EMA preference for further testing in RCTs. STUDY DESIGN AND SETTING: We reviewed all initial marketing authorizations in the EMA database on human medicines between 1995 and 2015 and included authorizations granted without randomized data. We extracted data on treatment effects and EMA preference for further testing in RCTs...
February 9, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29424772/systematic-identification-of-correlates-of-hiv-infection-an-x-wide-association-study
#4
Chirag J Patel, Jay Bhattacharya, John P A Ioannidis, Eran Bendavid
OBJECTIVE: Better identification of at-risk groups could benefit HIV-1 care programmes. We systematically identified HIV-1 risk factors in two nationally representative cohorts of women in the Demographic and Health Surveys. METHODS: We identified and replicated the association of 1415 social, economic, environmental, and behavioral factors with HIV-1 status. We used the 2007 and 2013-2014 surveys conducted among 5715 and 15 433 Zambian women, respectively (688 shared factors)...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29410855/modelling-science-trustworthiness-under-publish-or-perish-pressure
#5
David Robert Grimes, Chris T Bauch, John P A Ioannidis
Scientific publication is immensely important to the scientific endeavour. There is, however, concern that rewarding scientists chiefly on publication creates a perverse incentive, allowing careless and fraudulent conduct to thrive, compounded by the predisposition of top-tier journals towards novel, positive findings rather than investigations confirming null hypothesis. This potentially compounds a reproducibility crisis in several fields, and risks undermining science and public trust in scientific findings...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29402659/the-effect-of-nutrition-and-sleep-habits-on-predisposition-for-metabolic-syndrome-in-greek-children
#6
Maria Efthymia Katsa, Anastasios Ioannidis, Sofia Zyga, Maria Tsironi, Paraskevas Koutsovitis, Stylianos Chatzipanagiotou, Demosthenes Panagiotakos, Athanasios Sachlas, Petros Kolovos, Kleopatra Routsi, Anna Maria Pistikou, Dafni Eleni Kougioumtzi Dimoliani, Andrea Paola Rojas Gil
PURPOSE: To investigate the effect of lifestyle habits in childhood Metabolic Syndrome (MTS). DESIGN AND METHODS: Descriptive correlation study with 480 participants (5-12 years old) using a specially designed questionnaire was conducted. Anthropometric and biochemical analyses were performed. RESULTS: Fifteen percent of children exhibited predisposition for MTS. Regarding sleep habits, logistic regression analysis (LRA) showed that hour of sleep -before 22:00- was associated with decreased waist circumference (WC%) (p = ...
February 2, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29386350/a-universal-standard-for-the-validation-of-blood-pressure-measuring-devices-association-for-the-advancement-of-medical-instrumentation-european-society-of-hypertension-international-organization-for-standardization-aami-esh-iso-collaboration-statement
#7
George S Stergiou, Bruce Alpert, Stephan Mieke, Roland Asmar, Neil Atkins, Siegfried Eckert, Gerhard Frick, Bruce Friedman, Thomas Graßl, Tsutomu Ichikawa, John P Ioannidis, Peter Lacy, Richard McManus, Alan Murray, Martin Myers, Paolo Palatini, Gianfranco Parati, David Quinn, Josh Sarkis, Andrew Shennan, Takashi Usuda, Jiguang Wang, Colin O Wu, Eoin O'Brien
In the past 30 years, several organizations, such as the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring, and the International Organization for Standardization (ISO), have developed protocols for clinical validation of BP measuring devices. However, it is recognized that science, as well as patients, consumers, and manufacturers, would be best served if all BP measuring devices were assessed for accuracy according to an agreed single validation protocol that had global acceptance...
January 31, 2018: Hypertension
https://www.readbyqxmd.com/read/29384983/a-universal-standard-for-the-validation-of-blood-pressure-measuring-devices-association-for-the-advancement-of-medical-instrumentation-european-society-of-hypertension-international-organization-for-standardization-aami-esh-iso-collaboration-statement
#8
George S Stergiou, Bruce Alpert, Stephan Mieke, Roland Asmar, Neil Atkins, Siegfried Eckert, Gerhard Frick, Bruce Friedman, Thomas Graßl, Tsutomu Ichikawa, John P Ioannidis, Peter Lacy, Richard McManus, Alan Murray, Martin Myers, Paolo Palatini, Gianfranco Parati, David Quinn, Josh Sarkis, Andrew Shennan, Takashi Usuda, Jiguang Wang, Colin O Wu, Eoin O'Brien
: In the last 30 years, several organizations, such as the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring and the International Organization for Standardization (ISO) have developed protocols for clinical validation of BP measuring devices. However, it is recognized that science, as well as patients, consumers and manufacturers would be best served if all BP measuring devices were assessed for accuracy according to an agreed single validation protocol that had global acceptance...
March 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29383638/possible-mechanisms-of-direct-cardiovascular-impact-of-glp-1-agonists-and-dpp4-inhibitors
#9
REVIEW
Vasiliki Bistola, Vaia Lambadiari, George Dimitriadis, Ioannis Ioannidis, Konstantinos Makrilakis, Nikolaos Tentolouris, Apostolos Tsapas, John Parissis
Diabetes mellitus is a leading cause of cardiovascular morbidity and mortality worldwide. Traditional antidiabetic therapies targeting hyperglycemia reduce diabetic microvascular complications but have minor effects on macrovascular complications, including cardiovascular disease. Instead, cardiovascular complications are improved by antidiabetic medications (metformin) and other therapies (statins, antihypertensive medications) ameliorating insulin resistance and other associated metabolic abnormalities. Novel classes of antidiabetic drugs have proven efficacious in improving glycemia, while at the same time exert beneficial effects on pathophysiologic mechanisms of diabetes-related cardiovascular disease...
January 31, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29374488/effects-of-dance-on-cognitive-function-among-older-adults-a-protocol-for-systematic-review-and-meta-analysis
#10
Asm Borhan, Patricia Hewston, Dafna Merom, Courtney Kennedy, George Ioannidis, Nancy Santesso, Pasqualina Santaguida, Lehana Thabane, Alexandra Papaioannou
BACKGROUND: Cognitive impairment is characterized by problems in thinking, memory, language, and judgment that are greater than cognitive changes in normal aging. Considering the unprecedented growth of the older adult population and the projected increase in the prevalence of cognitive impairment, it is imperative to find effective strategies to improve or maintain cognitive function in older adults. The objective of this review is to summarize the effects of dance versus any other control group on cognitive function, physical function, adverse events, and quality of life in older adults...
January 27, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29373992/beyond-genomics-understanding-exposotypes-through-metabolomics
#11
REVIEW
Nicholas J W Rattray, Nicole C Deziel, Joshua D Wallach, Sajid A Khan, Vasilis Vasiliou, John P A Ioannidis, Caroline H Johnson
BACKGROUND: Over the past 20 years, advances in genomic technology have enabled unparalleled access to the information contained within the human genome. However, the multiple genetic variants associated with various diseases typically account for only a small fraction of the disease risk. This may be due to the multifactorial nature of disease mechanisms, the strong impact of the environment, and the complexity of gene-environment interactions. Metabolomics is the quantification of small molecules produced by metabolic processes within a biological sample...
January 26, 2018: Human Genomics
https://www.readbyqxmd.com/read/29371070/immunogenicity-and-safety-of-the-multicomponent-meningococcal-b-vaccine-4cmenb-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#12
Maria Elena Flacco, Lamberto Manzoli, Annalisa Rosso, Carolina Marzuillo, Mario Bergamini, Armando Stefanati, Rosario Cultrera, Paolo Villari, Walter Ricciardi, John P A Ioannidis, Despina G Contopoulos-Ioannidis
BACKGROUND: The multicomponent meningococcal serogroup B vaccine (4CMenB) has been licensed in more than 35 countries. However, uncertainties remain about the lowest number of doses required to induce satisfactory, persistent immune responses. We did a systematic review and meta-analysis to provide quantitative estimates for the immunogenicity, persistence of immunogenicity, and safety of 4CMenB vaccine in children and adolescents. METHODS: For this systematic review and meta-analyses (proportion, head to head, and network), we searched MEDLINE, Scopus, Embase, and ClinicalTrials...
January 19, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29369337/improving-the-integrity-of-published-science-an-expanded-taxonomy-of-retractions-and-corrections
#13
Daniele Fanelli, John Pa Ioannidis, Steven Goodman
Policies and practices to correct and retract scientific articles suffer from numerous limitations that are increasingly discussed in the literature. We briefly summarize these issues and propose a new and unified taxonomy of amendment types. The proposed 13-category system both simplifies and expands existing classifications and may be used as a heuristic tool to retrospectively classify literature amendments, as a taxonomy for electronic tagging, and as a blueprint for new amendment formats that journal editors could experiment with...
January 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29362788/altmetric-scores-citations-and-publication-of-studies-posted-as-preprints
#14
Stylianos Serghiou, John P A Ioannidis
No abstract text is available yet for this article.
January 23, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29352556/what-causes-psychosis-an-umbrella-review-of-risk-and-protective-factors
#15
Joaquim Radua, Valentina Ramella-Cravaro, John P A Ioannidis, Abraham Reichenberg, Nacharin Phiphopthatsanee, Taha Amir, Hyi Yenn Thoo, Dominic Oliver, Cathy Davies, Craig Morgan, Philip McGuire, Robin M Murray, Paolo Fusar-Poli
Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and protective factors have been suggested. This umbrella review aimed to classify the strength of evidence for the associations between each factor and psychotic disorders whilst controlling for several biases. The Web of Knowledge database was searched to identify systematic reviews and meta-analyses of observational studies which examined associations between socio-demographic, parental, perinatal, later factors or antecedents and psychotic disorders, and which included a comparison group of healthy controls, published from 1965 to January 31, 2017...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29349708/cost-effectiveness-of-empagliflozin-for-the-treatment-of-patients-with-type-2-diabetes-mellitus-at-increased-cardiovascular-risk-in-greece
#16
George Gourzoulidis, Charalampos Tzanetakos, Ioannis Ioannidis, Apostolos Tsapas, Georgia Kourlaba, Giannis Papageorgiou, Nikos Maniadakis
BACKGROUND AND OBJECTIVE: Type 2 diabetes mellitus (T2DM) is frequently associated with co-morbidities that exacerbate cardiovascular (CV) risk. CV disease is the leading cause of death in people with diabetes across the world and accounts for approximately half the deaths in the T2DM population. Hence, the objective of present study was to evaluate the cost-effectiveness of empagliflozin, in addition to standard of care (SoC), for the treatment of adult patients with T2DM and high CV risk in Greece...
January 18, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29325575/routinely-collected-data-for-randomized-trials-promises-barriers-and-implications
#17
REVIEW
Kimberly A Mc Cord, Rustam Al-Shahi Salman, Shaun Treweek, Heidi Gardner, Daniel Strech, William Whiteley, John P A Ioannidis, Lars G Hemkens
BACKGROUND: Routinely collected health data (RCD) are increasingly used for randomized controlled trials (RCTs). This can provide three major benefits: increasing value through better feasibility (reducing costs, time, and resources), expanding the research agenda (performing trials for research questions otherwise not amenable to trials), and offering novel design and data collection options (e.g., point-of-care trials and other designs directly embedded in routine care). However, numerous hurdles and barriers must be considered pertaining to regulatory, ethical, and data aspects, as well as the costs of setting up the RCD infrastructure...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29321002/comparison-of-nuisance-parameters-in-pediatric-versus-adult-randomized-trials-a-meta-epidemiologic-empirical-evaluation
#18
Ben Vandermeer, Ingeborg van der Tweel, Marijke C Jansen-van der Weide, Stephanie S Weinreich, Despina G Contopoulos-Ioannidis, Dirk Bassler, Ricardo M Fernandes, Lisa Askie, Haroon Saloojee, Paola Baiardi, Susan S Ellenberg, Johanna H van der Lee
BACKGROUND: We wished to compare the nuisance parameters of pediatric vs. adult randomized-trials (RCTs) and determine if the latter can be used in sample size computations of the former. METHODS: In this meta-epidemiologic empirical evaluation we examined meta-analyses from the Cochrane Database of Systematic-Reviews, with at least one pediatric-RCT and at least one adult-RCT. Within each meta-analysis of binary efficacy-outcomes, we calculated the pooled-control-group event-rate (CER) across separately all pediatric and adult-trials, using random-effect models and subsequently calculated the control-group event-rate risk-ratio (CER-RR) of the pooled-pediatric-CERs vs...
January 10, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29320509/dynamics-of-co-authorship-and-productivity-across-different-fields-of-scientific-research
#19
Austin J Parish, Kevin W Boyack, John P A Ioannidis
We aimed to assess which factors correlate with collaborative behavior and whether such behavior associates with scientific impact (citations and becoming a principal investigator). We used the R index which is defined for each author as log(Np)/log(I1), where I1 is the number of co-authors who appear in at least I1 papers written by that author and Np are his/her total papers. Higher R means lower collaborative behavior, i.e. not working much with others, or not collaborating repeatedly with the same co-authors...
2018: PloS One
https://www.readbyqxmd.com/read/29312879/posterior-cortical-atrophy-the-value-of-neuroimaging-in-assessing-memory-loss
#20
Stefanos Ioannidis, Helam Roseman, Kenneth Chan, Stephane Duckett, Ruth Mizoguchi
No abstract text is available yet for this article.
December 2017: Quantitative Imaging in Medicine and Surgery
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