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https://www.readbyqxmd.com/read/29228018/genome-wide-association-study-identifies-a-locus-associated-with-rotator-cuff-injury
#1
Thomas R Roos, Andrew K Roos, Andrew L Avins, Marwa A Ahmed, John P Kleimeyer, Michael Fredericson, John P A Ioannidis, Jason L Dragoo, Stuart K Kim
Rotator cuff tears are common, especially in the fifth and sixth decades of life, but can also occur in the competitive athlete. Genetic differences may contribute to overall injury risk. Identifying genetic loci associated with rotator cuff injury could shed light on the etiology of this injury. We performed a genome-wide association screen using publically available data from the Research Program in Genes, Environment and Health including 8,357 cases of rotator cuff injury and 94,622 controls. We found rs71404070 to show a genome-wide significant association with rotator cuff injury with p = 2...
2017: PloS One
https://www.readbyqxmd.com/read/29222543/disclosures-in-nutrition-research-why-it-is-different
#2
John P A Ioannidis, John F Trepanowski
No abstract text is available yet for this article.
December 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29220515/busco-applications-from-quality-assessments-to-gene-prediction-and-phylogenomics
#3
Robert M Waterhouse, Mathieu Seppey, Felipe A Simão, Mosè Manni, Panagiotis Ioannidis, Guennadi Klioutchnikov, Evgenia V Kriventseva, Evgeny M Zdobnov
Genomics promises comprehensive surveying of genomes and metagenomes, but rapidly changing technologies and expanding data volumes make evaluation of completeness a challenging task. Technical sequencing quality metrics can be complemented by quantifying completeness of genomic datasets in terms of the expected gene content of Benchmarking Universal Single-Copy Orthologs (BUSCO, http://busco.ezlab.org). The latest software release implements a complete refactoring of the code to make it more flexible and extendable to facilitate high-throughput assessments...
December 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29218215/leiomyoma-of-round-ligament-mimicking-an-incarcerated-inguinal-hernia-report-of-a-rare-case
#4
Christoforos Efthimiadis, Aristeidis Ioannidis, Marios Grigoriou, Konstantinia Kofina, Domniki Gerasimidou
Inguinal hernia is a common condition and may contain small or large bowel, omentum or other tissues. Leiomyomas of a round ligament are a rare condition occurring predominantly in premenopausal women. Abdominal, inguinal and vulvar locations have been described. Rare situations have been reported in which leiomyomas resemble to an incarcerated inguinal hernia. We describe a rare case of a leiomyoma of a round ligament in a young Caucasian female mimicking an incarcerated inguinal hernia. The treatment was surgical and we were able to remove the leiomyoma of the round ligament successfully...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29218214/use-of-botulinum-a-toxin-for-proctalgia-fugax-a-case-report-of-successful-treatment
#5
Marios Grigoriou, Aristeidis Ioannidis, Konstantinia Kofina, Christoforos Efthimiadis
Proctalgia fugax is considered as intermittent anal pain of unknown etiology; a variety of treatments have been used, without, however, permanent results. Injection of botulinum A toxin is recently suggested as an alternative option. We present the case of a woman presenting proctalgia fugax that was untreatable through other current forms of treatment. After two administrations of botulinum A toxin, 80 units and 100 units each, the patient remained asymptomatic on 8-month follow-up control. Botulinum A toxin injection can reduce internal anal sphincter pressure, leading to relief of symptoms, and seems a promising option with minimal morbidity in cases on proctalgia fugax that does not respond to other current treatments...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29211824/corrigendum-systematic-reviews-guidance-relevant-for-studies-of-older-people
#6
Susan D Shenkin, Jennifer K Harrison, Tim Wilkinson, Richard M Dodds, John P A Ioannidis
No abstract text is available yet for this article.
December 2, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29191447/comparative-evidence-on-harms-in-pediatric-rcts-from-less-developed-versus-more-developed-countries-is-limited
#7
REVIEW
Dario Tedesco, Mufiza Farid-Kapadia, Martin Offringa, Zulfiqar A Bhutta, Yvonne Maldonado, John P A Ioannidis, Despina G Contopoulos-Ioannidis
OBJECTIVE: Evaluate comparative harm-rates from medical interventions in pediatric randomized-trials (RCTs) from more-developed (MDCs) and less-developed countries (LDCs). STUDY DESIGN: Meta-epidemiologic empirical evaluation of Cochrane Database of Systematic Reviews (June 2014) meta-analyses reporting clinically-important harm-outcomes (severe adverse events [AEs], discontinuations due to AEs, any AE and mortality) that included at least 1 pediatric-RCT from MDCs and at least 1 from LDCs...
November 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29184794/should-we-expand-the-indications-for-varicocele-treatment
#8
REVIEW
Ioannis Vakalopoulos, Spyridon Kampantais, Stefania Lymperi, Nikolaos Grivas, Anastasios Ioannidis, Ioannis Mykoniatis, Vassilios Nikolaou, Georgios Dimitriadis
Current guidelines suggest that treatment of varicocele should be considered in patients with clinically palpable disease and abnormal semen parameters. However, the clinicians are often challenged with the decision whether to treat varicocele in patients with testicular pain or low testosterone levels. Moreover, varicocele is highly associated with DNA fragmentation due to the oxidative stress and it has been demonstrated that surgical repair of varicocele ameliorates oxidative stress markers and consequently the sperm DNA integrity...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29174118/poor-performance-of-clinical-prediction-models-the-harm-of-commonly-applied-methods
#9
Ewout W Steyerberg, Hajime Uno, John P A Ioannidis, Ben van Calster, Chinedu Ukaegbu, Tara Dhingra, Sapna Syngal, Fay Kastrinos
OBJECTIVE: To evaluate limitations of common statistical modeling approaches in deriving clinical prediction models and explore alternative strategies. STUDY DESIGN AND SETTING: A previously published model predicted the likelihood of having a mutation at the time of diagnosis of colorectal cancer. This model was based on a cohort where 38 mutations were found among 870 participants, with validation in an independent cohort with 35 mutations. The modeling strategy included stepwise selection of predictors from a pool of 37 candidate predictors and dichotomization of continuous predictors...
November 23, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29173632/microbiological-chemical-and-sensory-spoilage-analysis-of-raw-atlantic-cod-gadus-morhua-stored-under-modified-atmospheres
#10
L Kuuliala, Y Al Hage, A-G Ioannidis, M Sader, F-M Kerckhof, M Vanderroost, N Boon, B De Baets, B De Meulenaer, P Ragaert, F Devlieghere
During fish spoilage, microbial metabolism leads to the production of volatile organic compounds (VOCs), characteristic off-odors and eventual consumer rejection. The aim of the present study was to contribute to the development of intelligent packaging technologies by identifying and quantifying VOCs that indicate spoilage of raw Atlantic cod (Gadus morhua) under atmospheres (%v/v CO2/O2/N2) 60/40/0, 60/5/35 and air. Spoilage was examined by microbiological, chemical and sensory analyses over storage time at 4 or 8 °C...
April 2018: Food Microbiology
https://www.readbyqxmd.com/read/29169611/the-conduct-and-reporting-of-child-health-research-an-analysis-of-randomized-controlled-trials-published-in-2012-and-evaluation-of-change-over-5-years
#11
Allison Gates, Lisa Hartling, Ben Vandermeer, Patrina Caldwell, Despina G Contopoulos-Ioannidis, Sarah Curtis, Ricardo M Fernandes, Terry P Klassen, Katrina Williams, Michele P Dyson
OBJECTIVES: For child health randomized controlled trials (RCTs) published in 2012, we aimed to describe design and reporting characteristics and evaluate changes since 2007; assess the association between trial design and registration and risk of bias (RoB); and assess the association between RoB and effect size. STUDY DESIGN: For 300 RCTs, we extracted design and reporting characteristics and assessed RoB. We assessed 5-year changes in design and reporting (based on 300 RCTs we had previously analyzed) using the Fisher exact test...
November 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29146752/physical-activity-and-cancer-an-umbrella-review-of-the-literature-including-22-major-anatomical-sites-and-770%C3%A2-000-cancer-cases
#12
REVIEW
Leandro Fórnias Machado de Rezende, Thiago Hérick de Sá, Georgios Markozannes, Juan Pablo Rey-López, I-Min Lee, Konstantinos K Tsilidis, John P A Ioannidis, José Eluf-Neto
OBJECTIVE: To provide an overview of the breadth and validity of claimed associations between physical activity and risk of developing or dying from cancer. DESIGN: Umbrella review. DATA SOURCES: We searched Medline, Embase, Cochrane Database and Web of Science. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Systematic reviews about physical activity and cancer incidence and cancer mortality in different body sites among general population...
November 16, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29146289/off-label-treatments-were-not-consistently-better-or-worse-than-approved-drug-treatments-in-randomized-trials
#13
Aviv Ladanie, John P A Ioannidis, Randall S Stafford, Hannah Ewald, Heiner C Bucher, Lars G Hemkens
BACKGROUND: Off-label drug use is highly prevalent, but controversial and often discouraged assuming generally inferior medical effects associated with off-label use. METHODS: We searched Medline, PubMed Health and the Cochrane Library up to May 2015 for systematic reviews including meta-analyses of randomized clinical trials (RCTs) comparing off-label and approved drugs head-to-head in any population and on any medical outcome. We combined the comparative effects in meta-analyses providing summary odds ratios (sOR) for each treatment comparison and outcome, and then calculated an overall summary of the sOR across all comparisons (ssOR)...
November 13, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29142041/occurrence-of-serious-infection-in-patients-with-rheumatoid-arthritis-treated-with-biologics-and-denosumab-observed-in-a-clinical-setting
#14
Arthur N Lau, Matthew Wong-Pack, Rod Rodjanapiches, George Ioannidis, Sally Wade, Leslie Spangler, Akhila Balasubramanian, Nicola Pannacciulli, Celia J F Lin, Patrick Roy-Gayos, William G Bensen, Robert Bensen, Jonathan D Adachi
OBJECTIVE: Previous studies combining biologic disease-modifying antirheumatic drugs (bDMARD) to treat rheumatoid arthritis (RA) have shown an increased risk of infection. However, the risk of infection with concurrent use of denosumab, a biologic agent for the treatment of osteoporosis, and a bDMARD remains unclear. Here, we evaluated the incidence of serious and opportunistic infections in patients treated concurrently with denosumab and a bDMARD and patients treated with a bDMARD alone...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29132301/measuring-frailty-in-clinical-practice-a-comparison-of-physical-frailty-assessment-methods-in-a-geriatric-out-patient-clinic
#15
J M Pritchard, C C Kennedy, S Karampatos, G Ioannidis, B Misiaszek, S Marr, C Patterson, T Woo, A Papaioannou
BACKGROUND: The objectives of this study were to determine: 1) the prevalence of frailty using Fried's phenotype method and the Short Performance Physical Battery (SPPB), 2) agreement between frailty assessment methods, 3) the feasibility of assessing frailty using Fried's phenotype method and the SPPB. METHODS: This cross-sectional study was conducted at a geriatric out-patient clinic in Hamilton, Canada. A research assistant conducted all frailty assessments. Patients were classified as non-frail, pre-frail or frail according to Fried's phenotype method and the SPPB...
November 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29117796/effects-of-varenicline-therapy-in-combination-with-advanced-behavioral-support-on-smoking-cessation-and-quality-of-life-in-inpatients-with-acute-exacerbation-of-copd-bronchial-asthma-or-community-acquired-pneumonia-a-prospective-open-label-preference-based
#16
Alexios Politis, Vasileios Ioannidis, Konstantinos I Gourgoulianis, Zoe Daniil, Chrissi Hatzoglou
Quitting smoking is the most important element in the therapeutic management of chronic respiratory diseases. Combining pharmacotherapy with behavioral support increases smoking cessation success rates. In addition, hospitalized smokers have increased motivation to quit. We investigated the efficacy on smoking cessation, of varenicline in combination with behavioral support, in smokers hospitalized due to (a) acute exacerbation of chronic obstructive pulmonary disease (COPD), or (b) bronchial asthma attack, or (c) community-acquired pneumonia (CAP)...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29095325/charcot-marie-tooth-disease-1x-simulating-paraparetic-guillain-barre-syndrome
#17
Dimitrios Parissis, Panagiotis Ioannidis, Georgios Papadopoulos, Dimitrios Karacostas
X-linked Charcot-Marie-Tooth disease (CMT 1X) is the second most common form of inherited demyelinating neuropathy. It is established that patients suffering from CMT 1X can have episodes of hemiparesis, paraparesis, quadriparesis, ataxia, aphasia, and dysarthria, which can be fully reversible, and 'trigger' factors for these episodes are usually febrile illness, high altitudes, hyperventilation, and physical activity. We describe a 22-year-old patient with a history of viral infection and sleep deprivation who presented to our department because of acute difficulty in walking and neurophysiological findings suggesting Guillain-Barre syndrome...
November 2017: Neurologist
https://www.readbyqxmd.com/read/29056694/inquiring-into-the-gaps-of-campylobacter-surveillance-methods
#18
REVIEW
Maria Magana, Stylianos Chatzipanagiotou, Angeliki R Burriel, Anastasios Ioannidis
Campylobacter is one of the most common pathogen-related causes of diarrheal illnesses globally and has been recognized as a significant factor of human disease for more than three decades. Molecular typing techniques and their combinations have allowed for species identification among members of the Campylobacter genus with good resolution, but the same tools usually fail to proceed to subtyping of closely related species due to high sequence similarity. This problem is exacerbated by the demanding conditions for isolation and detection from the human, animal or water samples as well as due to the difficulties during laboratory maintenance and long-term storage of the isolates...
July 19, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29055626/pulmonary-arterial-hypertension-with-abnormal-v-q-single-photon-emission-computed-tomography
#19
Kenneth Chan, Stefanos Ioannidis, John G Coghlan, Margaret Hall, Benjamin E Schreiber
OBJECTIVES: This study aimed to evaluate the incidence and clinical outcomes of abnormal ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT) without thromboembolism, especially in patients with group I pulmonary arterial hypertension (PAH). BACKGROUND: American Heart Association/American College of Cardiology and European Society of Cardiology guidelines recommend V/Q scan for screening for chronic thromboembolic pulmonary hypertension...
October 16, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29045389/molecular-basis-of-usp7-inhibition-by-selective-small-molecule-inhibitors
#20
Andrew P Turnbull, Stephanos Ioannidis, Wojciech W Krajewski, Adan Pinto-Fernandez, Claire Heride, Agnes C L Martin, Louise M Tonkin, Elizabeth C Townsend, Shane M Buker, David R Lancia, Justin A Caravella, Angela V Toms, Thomas M Charlton, Johanna Lahdenranta, Erik Wilker, Bruce C Follows, Nicola J Evans, Lucy Stead, Cristina Alli, Vladislav V Zarayskiy, Adam C Talbot, Alexandre J Buckmelter, Minghua Wang, Crystal L McKinnon, Fabienne Saab, Joanna F McGouran, Hannah Century, Malte Gersch, Marc S Pittman, C Gary Marshall, Tony M Raynham, Mary Simcox, Lorna M D Stewart, Sheila B McLoughlin, Jaime A Escobedo, Kenneth W Bair, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, Sylvie Urbé, Michael J Clague, Benedikt M Kessler, David Komander
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the degradation of selected proteins, potentially including otherwise 'undruggable' targets. For example, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degradation of the oncogenic E3 ligase MDM2, and leads to re-activation of the tumour suppressor p53 in various cancers. Here we report that two compounds, FT671 and FT827, inhibit USP7 with high affinity and specificity in vitro and within human cells...
October 26, 2017: Nature
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