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Silvia Fraga, Joaquim Soares, Maria Gabriella Melchiorre, Henrique Barros, Bahareh Eslami, Elisabeth Ioannidi-Kapolou, Jutta Lindert, Gloria Macassa, Mindaugas Stankunas, Francisco Torres-Gonzales, Eija Viitasara
Few studies have evaluated the impact of lifetime abuse on quality of life (QoL) among older adults. By using a multinational study authors aimed to assess the subjective perception of QoL among people who have reported abuse during the course of their lifetime. The respondents (N = 4,467; 2,559 women) were between the ages of 60 and 84 years and living in seven European countries (Germany, Greece, Italy, Lithuania, Portugal, Spain, and Sweden). Lifetime abuse was assessed by using a structured questionnaire that allowed to assess lifetime experiences of abuse...
August 31, 2017: Health & Social Work
Paulina Majewska, Stefanos Ioannidis, Muhammad Hasan Raza, Nikhil Tanna, Helen Bulbeck, Mathew Williams
Glioblastoma is the commonest malignant brain tumor in adults. Most patients develop progressive disease before they die. However, survival after developing progressive disease is infrequently reported. We identified patients with histologically proven disease who were treated with concurrent chemoradiotherapy during 2006-2013. We analyzed overall survival (OS), progression-free survival and postprogression survival (PPS) in relation to age, O6-methylguanine-DNA methyltransferase promoter methylation and extent of surgical resection...
October 9, 2017: CNS Oncology
Stuart K Kim, Marwa A Ahmed, Andy L Avins, John P A Ioannidis
De Quervain's tenosynovitis is a repetitive strain injury involving synovial inflammation of the tendons of the first extensor compartment of the wrist. It is relatively common in the general population, and is the most common radial-sided tendinopathy seen in athletes. Identifying a genetic marker associated with de Quervain's tenosynovitis could provide a useful tool to help identify those individuals with an increased risk for injury. A genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health (RPGEH) including 4,129 cases and 98,374 controls...
October 6, 2017: International Journal of Sports Medicine
George Karabatsos
There is growing concern that much of the published research literature is distorted by the pursuit of statistically significant results. In a seminal article, Ioannidis and Trikalinos (2007, Clinical Trials) proposed an omnibus (I&T) test for significance chasing (SC) biases. This test compares the observed number of studies that report statistically-significant results, against their expected number based on study power, assuming a common effect size across studies. The current article extends this approach by developing a Bayesian nonparametric (BNP) meta-regression model and test of SC bias, which can diagnose bias at the individual study level...
October 6, 2017: Research Synthesis Methods
John P A Ioannidis
Greece has undergone a distressing crisis that has taken a heavy toll, devaluing lives of individuals and functions of society at large. Besides the economic meltdown, there has been an even worse crisis of values. The country currently occupies a low rank in the WHO Happiness Index (1) (99(th) in 2016 and 87(th) in 2017), not so much because of worsening ranking in healthy life expectancy (still ranked 24(th) in the world in 2017) or even wealth (still ranked 44(th) in GDP per capita), but because of mediocre ranking in social support (ranked 80(th) ) and extremely low rankings in freedom to make life choices (ranked 150(th) among 155 countries), generosity (ranked 155(th) , i...
October 5, 2017: European Journal of Clinical Investigation
Stavroula Lambrinakou, Maria Efthymia Katsa, Sofia Zyga, Anastasios Ioannidis, Athanasios Sachlas, Georgios Panoutsopoulos, Anna Maria Pistikou, Maria Magana, Dafni Eleni Kougioumtzi Dimoligianni, Petros Kolovos, Andrea Paola Rojas Gil
BACKGROUND: Anxiety combined with nervousness and apprehension consist a focal response to different life conditions. Lifestyle habits, anxiety and biochemical markers are in a constant interaction. AIM: To investigate the prevalence of anxiety in healthy adults and its possible association with biochemical factors-lipid profile, liver markers, thyroid hormones-and lifestyle habits. METHODS: Quantitative descriptive correlation study. A total of 100 healthy adults participated in the research...
2017: Advances in Experimental Medicine and Biology
Nilah M Ioannidis, Joe R Davis, Marianne K DeGorter, Nicholas B Larson, Shannon K McDonnell, Amy J French, Alexis J Battle, Trevor J Hastie, Stephen N Thibodeau, Stephen B Montgomery, Carlos D Bustamante, Weiva Sieh, Alice S Whittemore
Motivation: Interpreting genetic variation in noncoding regions of the genome is an important challenge for personal genome analysis. One mechanism by which noncoding single nucleotide variations (SNVs) influence downstream phenotypes is through the regulation of gene expression. Methods to predict whether or not individual SNVs are likely to regulate gene expression would aid interpretation of variants of unknown significance identified in whole-genome sequencing studies. Results: We developed FIRE (Functional Inference of Regulators of Expression), a tool to score both noncoding and coding SNVs based on their potential to regulate the expression levels of nearby genes...
August 24, 2017: Bioinformatics
Stuart K Kim, John P Kleimeyer, Marwa A Ahmed, Andrew L Avins, Michael Fredericson, Jason L Dragoo, John P A Ioannidis
Ankle injuries, including sprains, strains and other joint derangements and instability, are common, especially for athletes involved in indoor court or jumping sports. Identifying genetic loci associated with these ankle injuries could shed light on their etiologies. A genome-wide association screen was performed using publicly available data from the Research Program in Genes, Environment and Health (RPGEH) including 1,694 cases of ankle injury and 97,646 controls. An indel (chr21:47156779:D) that lies close to a collagen gene, COL18A1, showed an association with ankle injury at genome-wide significance (p = 3...
2017: PloS One
Charlotte Kelly, Paulina Majewska, Stefanos Ioannidis, Muhammad Hasan Raza, Matt Williams
Glioblastoma (GBM) represents 80% of all primary malignant brain tumours in adults. Prognosis is poor, and there is a clear correlation between disease progression and deterioration in functional status. In this pilot study we assess whether we can estimate disease progression and progression free survival (PFS) from routinely collected electronic healthcare data. We identified fifty patients with glioblastoma who had chemo-radiotherapy. For each patient we manually collected a reference data set recording demographics, surgery, radiotherapy, chemotherapy, follow-up and death...
September 27, 2017: Journal of Neuro-oncology
Constantinos S Psomopoulos, Dimitrios A Barkas, Stavros D Kaminaris, George C Ioannidis, Panagiotis Karagiannopoulos
Low voltage and high voltage high-rupturing-capacity fuse links are used in LV and HV installations respectively, protecting mainly the LV and HV electricity distribution and transportation networks. The Waste Electrical and Electronic Equipment Directive (2002/96/EC) for "Waste of electrical and electronic equipment" is the main related legislation and as it concerns electrical and electronic equipment, it includes electric fuses. Although, the fuse links consist of recyclable materials, only small scale actions have been implemented for their recycling around Europe...
September 23, 2017: Waste Management
M Koller, M J Hjermstad, K A Tomaszewski, I M Tomaszewska, K Hornslien, A Harle, J I Arraras, O Morag, C Pompili, G Ioannidis, M Georgiou, C Navarra, W-C Chie, C D Johnson, A Himpel, C Schulz, T Bohrer, A Janssens, D Kulis, A Bottomley
BACKGROUND: The EORTC QLQ-LC13 was the first module to be used in conjunction with the core questionnaire, the QLQ-C30. Since the publication of the LC13 in 1994, major advances have occurred in the treatment of lung cancer. Given this, an update review of the EORTC QLQ-LC13 was undertaken. METHODS: The study followed Phases 1 to 3 of the EORTC Module Development Guidelines. Phase 1 generated relevant quality of life issues using a mix of sources including the involvement of 108 lung cancer patients...
August 22, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Lars G Hemkens, Hannah Ewald, Florian Naudet, Aviv Ladanie, Jonathan G Shaw, Gautam Sajeev, John P A Ioannidis
BACKGROUND: Confounding bias is a most pervasive threat to validity of observational epidemiological research. METHODS: We assessed whether authors of observational epidemiological studies consider confounding bias when interpreting the findings. We randomly selected 120 cohort or case-control studies published in 2011 and 2012 by the general medical, epidemiological, and specialty journals with the highest impact factors. We used Web of Science to assess citation metrics through January 2017...
September 21, 2017: Journal of Clinical Epidemiology
F Salim, M Ioannidis, T Górecki
A mathematical model describing the sampling process in a permeation-based passive sampler was developed and evaluated numerically. The model was applied to the Waterloo Membrane Sampler (WMS), which employs a polydimethylsiloxane (PDMS) membrane as a permeation barrier, and an adsorbent as a receiving phase. Samplers of this kind are used for sampling volatile organic compounds (VOC) from air and soil gas. The model predicts the spatio-temporal variation of sorbed and free analyte concentrations within the sampler components (membrane, sorbent bed and dead volume), from which the uptake rate throughout the sampling process can be determined...
September 22, 2017: Environmental Science. Processes & Impacts
Andreas Lauenroth, Stephan Schulze, Anestis Ioannidis, Andreas Simm, Rene Schwesig
Age simulation suits are used to demonstrate typical physical impairments of older age (e.g., strength and sensory losses) in younger individuals. The purpose of the current study was to describe gait performance in different age groups while wearing an age simulation suit. A total of 178 participants ages 18 to 85 (mean age = 50.4 years, SD = 16.4 years) were assigned according to their age decade to four groups with (ages 18 to 59) and two groups without (ages 60 to 85) the aging suit. Gait performance was measured with a gait analysis system (GAITRite(®)) while walking at a self-chosen pace...
September 1, 2017: Research in Gerontological Nursing
Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios G Goulis, Andromachi Vryonidou
OBJECTIVE: The aim of this study was to investigate the impact of adrenal hyperandrogenism on insulin resistance and lipid profile in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: We studied 372 women with PCOS according to the NIH criteria. 232 age- and BMI-matched women served as controls in order to define adrenal hyperandrogenism (DHEA-S >95th percentile). Then, patients with PCOS were classified into two groups: with adrenal hyperandrogenism (PCOS-AH, n = 108) and without adrenal hyperandrogenism (PCOS-NAH, n = 264)...
November 2017: Endocrine Connections
Kalliopi Despoudi, Ioannis Mantzoros, Orestis Ioannidis, Aggeliki Cheva, Nikolaos Antoniou, Dimitrios Konstantaras, Savvas Symeonidis, Manousos George Pramateftakis, Efstathios Kotidis, Stamatis Angelopoulos, Konstantinos Tsalis
AIM: To evaluate the effect of local surgical adhesive glue (albumin/glutaraldehyde-Bioglue) on the healing of colonic anastomoses in rats. METHODS: Forty Albino-Wistar male rats were randomly divided into two groups, with two subgroups of ten animals each. In the control group, an end-to-end colonic anastomosis was performed after segmental resection. In the Bioglue group, the anastomosis was protected with extraluminar application of adhesive glue containing albumin and glutaraldehyde...
August 21, 2017: World Journal of Gastroenterology: WJG
John P A Ioannidis, Michael E Stuart, Shannon Brownlee, Sheri A Strite
Most physicians and other healthcare professionals are unaware of the pervasiveness of poor quality clinical evidence that contributes considerably to overuse, underuse, avoidable adverse events, missed opportunities for right care and wasted healthcare resources. The Medical Misinformation Mess comprises four key problems. First, much published medical research is not reliable or is of uncertain reliability, offers no benefit to patients, or is not useful to decision makers. Second, most healthcare professionals are not aware of this problem...
September 7, 2017: European Journal of Clinical Investigation
Sami P Moubayed, John P A Ioannidis, Mikhail Saltychev, Sam P Most
Importance: Rhinoplasty is a common operation in which shape and function are intimately related, whether the procedure is cosmetic, functional, or combined in nature. There is currently no properly developed and validated patient-reported outcome measure (PROM) to evaluate both functional and cosmetic components of rhinoplasty. Objective: To develop, validate, and field test the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) to evaluate both functional and cosmetic outcomes of rhinoplasty...
September 7, 2017: JAMA Facial Plastic Surgery
Yining Han, Navid Bizmark, Nasser Mohieddin Abukhdeir, Marios A Ioannidis
Design and fabrication of many next-generation liquid crystal (LC)-based devices rely on nematic LC domains in the form of drops or emulsions. In addition to surfactants, solid nanoparticles may be used to stabilize LC-in-water Pickering emulsions, possibly adding new dimensions to device functionality. In this work we quantitatively study the adsorption of ethyl cellulose (EC) nanoparticles, as a colloid model system, on the 4-cyano-4'-pentylbiphenyl (5CB)-water interface via a series of dynamic interfacial tension measurements...
September 20, 2017: Physical Chemistry Chemical Physics: PCCP
George Ioannidis, Micaela Jantzi, Jenn Bucek, Jonathan D Adachi, Lora Giangregorio, John Hirdes, Laura Pickard, Alexandra Papaioannou
OBJECTIVES: To develop and validate our Fracture Risk Scale (FRS) over a 1-year time period, using the long-term care (LTC) Resident Assessment Instrument Minimum Data Set Version 2.0 (RAI-MDS 2.0). DESIGN: A retrospective cohort study. SETTING: LTC homes in Ontario, Canada. PARTICIPANTS: Older adults who were admitted to LTC and received a RAI-MDS 2.0 admission assessment between 2006 and 2010. RESULTS: A total of 29 848 LTC residents were enrolled in the study...
September 1, 2017: BMJ Open
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