keyword
MENU ▼
Read by QxMD icon Read
search

Ioannidis

keyword
https://www.readbyqxmd.com/read/28077235/drivers-of-poor-medical-care
#1
REVIEW
Vikas Saini, Sandra Garcia-Armesto, David Klemperer, Valerie Paris, Adam G Elshaug, Shannon Brownlee, John P A Ioannidis, Elliott S Fisher
The global ubiquity of overuse and underuse of health-care resources and the gravity of resulting harms necessitate an investigation of drivers to inform potential solutions. We describe the network of influences that contribute to poor care and suggest that it is driven by factors that fall into three domains: money and finance; knowledge, bias, and uncertainty; and power and human relationships. In each domain the drivers operate at the global, national, regional, and individual level, and are modulated by the specific contexts within which they act...
January 6, 2017: Lancet
https://www.readbyqxmd.com/read/28073328/what-constitutes-strong-psychological-science-the-neglected-role-of-diagnosticity-and-a-priori-theorizing
#2
Klaus Fiedler
A Bayesian perspective on Ioannidis's (2005) memorable statement that "Most Published Research Findings Are False" suggests a seemingly inescapable trade-off: It appears as if research hypotheses are based either on safe ground (high prior odds), yielding valid but unsurprising results, or on unexpected and novel ideas (low prior odds), inspiring risky and surprising findings that are inevitably often wrong. Indeed, research of two prominent types, sexy hypothesis testing and model testing, is often characterized by low priors (due to astounding hypotheses and conjunctive models) as well as low-likelihood ratios (due to nondiagnostic predictions of the yin-or-yang type)...
January 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28059518/ligand-field-dependent-behavior-of-meta-gga-exchange-in-transition-metal-complex-spin-state-ordering
#3
Efthymios I Ioannidis, Heather J Kulik
Prediction of spin-state ordering in transition metal complexes is essential for understanding catalytic activity and designing functional materials. Semi-local approximations in density functional theory, such as the generalized-gradient approximation (GGA), suffer from delocalization error that gives rise to systematic bias for low-spin electronic states. Incorporation of exact exchange is known to counteract this bias, instead favoring high-spin states, in a manner that has recently been identified to be ligand-field dependent...
January 6, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28027950/dietfits-study-diet-intervention-examining-the-factors-interacting-with-treatment-success-study-design-and-methods
#4
Michael Stanton, Jennifer Robinson, Susan Kirkpatrick, Sarah Farzinkhou, Erin Avery, Joseph Rigdon, Lisa Offringa, John Trepanowski, Michelle Hauser, Jennifer Hartle, Rise Cherin, Abby C King, John P A Ioannidis, Manisha Desai, Christopher D Gardner
Numerous studies have attempted to identify successful dietary strategies for weight loss, and many have focused on Low-Fat vs. Low-Carbohydrate comparisons. Despite relatively small between-group differences in weight loss found in most previous studies, researchers have consistently observed relatively large between-subject differences in weight loss within any given diet group (e.g., ~25kg weight loss to ~5kg weight gain). The primary objective of this study was to identify predisposing individual factors at baseline that help explain differential weight loss achieved by individuals assigned to the same diet, particularly a pre-determined multi-locus genotype pattern and insulin resistance status...
December 24, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28004846/short-term-economic-impact-of-the-zika-virus-outbreak
#5
Daniele Macciocchi, Simone Lanini, Francesco Vairo, Alimuddin Zumla, Luiz Tadeu Moraes Figueiredo, Francesco Nicola Lauria, Gino Strada, Philippe Brouqui, Vincenzo Puro, Sanjeev Krishna, Peter Kremsner, Paola Scognamiglio, Carsten Köhler, Emanuele Nicastri, Antonino Di Caro, Rodolfo Maria Cieri, John P A Ioannidis, Gary Kobinger, Marcelo Nascimento Burattini, Giuseppe Ippolito
Zika virus (ZIKV) is mainly transmitted by mosquitoes bites. However, transmission by sexual contacts has been reported in 11 non endemic countries. The rapid spread of ZIKV in Latin American and Caribbean Countries (LCR), person-to-person transmission and perceived risk on people's well being can affect the emerging economies of LCR which historically dependent on truism. Here we present an analysis on economic outputs for assessing the current impact of ZIKV on markets. Our analysis show an unexpected resilience of LCR markets to international alerts...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/28004011/methods-to-enhance-the-reproducibility-of-precision-medicine
#6
Arjun K Manrai, Chirag J Patel, Nils Gehlenborg, Nicholas P Tatonetti, John P A Ioannidis, Isaac S Kohane
No abstract text is available yet for this article.
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27998906/biomedical-journals-and-preprint-services-friends-or-foes
#7
Thomas Annesley, Mitchell Scott, Hilda Bastian, Vivian Fonseca, John P A Ioannidis, Michael A Keller, Jessica Polka
No abstract text is available yet for this article.
December 20, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27971628/cost-effectiveness-of-secukinumab-compared-with-ustekinumab-and-etanercept-for-the-treatment-of-moderate-to-severe-plaque-psoriasis-in-greece
#8
C Tzanetakos, G Kourlaba, M Chatzikou, C Antoniou, D Ioannidis, Lefaki, A Petridis, D Rigopoulos, A Roussaki-Schulze, D Sotiriadis, N Maniadakis
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27940837/enhancing-reproducibility-for-computational-methods
#9
Victoria Stodden, Marcia McNutt, David H Bailey, Ewa Deelman, Yolanda Gil, Brooks Hanson, Michael A Heroux, John P A Ioannidis, Michela Taufer
No abstract text is available yet for this article.
December 9, 2016: Science
https://www.readbyqxmd.com/read/27927820/headache-in-an-hiv-positive-patient-diagnostic-challenges-and-approach-to-treatment%C3%A2
#10
Andrew Creamer, Stefanos Ioannidis, Thomas Wilhelm, Tabitha Mahangu, Marc Lipman
Headaches are a common complaint in HIV positive patients attending emergency services. A thorough understanding of the differential diagnoses, initial investigations and empirical management of this presentation is essential for the assessing physician. We discuss a case of a patient with known advanced HIV infection presenting with headache to the emergency department. Given the range of possible diagnoses, broad-spectrum antimicrobial therapy was initially commenced. This was stopped when magnetic resonance imaging confirmed a diagnosis of venous sinus thrombosis...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27927232/publication-of-nuclear-magnetic-resonance-experimental-data-with-semantic-web-technology-and-the-application-thereof-to-biomedical-research-of-proteins
#11
Masashi Yokochi, Naohiro Kobayashi, Eldon L Ulrich, Akira R Kinjo, Takeshi Iwata, Yannis E Ioannidis, Miron Livny, John L Markley, Haruki Nakamura, Chojiro Kojima, Toshimichi Fujiwara
BACKGROUND: The nuclear magnetic resonance (NMR) spectroscopic data for biological macromolecules archived at the BioMagResBank (BMRB) provide a rich resource of biophysical information at atomic resolution. The NMR data archived in NMR-STAR ASCII format have been implemented in a relational database. However, it is still fairly difficult for users to retrieve data from the NMR-STAR files or the relational database in association with data from other biological databases. FINDINGS: To enhance the interoperability of the BMRB database, we present a full conversion of BMRB entries to two standard structured data formats, XML and RDF, as common open representations of the NMR-STAR data...
May 5, 2016: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/27922642/threshold-values-for-the-perception-of-color-changes-in-human-teeth
#12
Daniel S Thoma, Alexis Ioannidis, Vincent Fehmer, Gioia Michelotti, Ronald E Jung, Irena Sailer
The aim of the present study was to assess the threshold values for color changes on the level of the tooth separately for laypeople, dentists, and dental technicians. Standardized presentations were made of five cases (maxilla, left to right lateral incisors) with the gingiva and teeth separated. The color parameters L (lightness), a, and b (chroma) (CIE L*a*b* parameters) of the tooth layers were adjusted to induce darker and lighter colors. In the presentations, the left part of the pictures (maxillary right central and lateral incisors) was unchanged, whereas the right part was modified...
November 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27920848/a-systematic-investigation-of-sclerosing-mesenteritis-through-ct-and-mri
#13
Sotirios Apostolakis, Argyrios Ioannidis, Garyfalia Tsioga, Konstantina Papageorgiou, Georgios Velimezis
Sclerosing mesenteritis is primarily diagnosed through histologic and radiologic evaluation; however, only a few works provide a systematic description using MRI. This work presents the case of a 68-year-old male, who was admitted for a routine cholecystectomy. Intraoperativly, a large mass was identified dislocating the abdominal viscera. The microscopic examination revealed vascular congestion of the omentum. The contrast-enhanced CT and MRI scans revealed the presence of a heterogenous, lipomatous mass with lesions visible only in T2W and contrast-enhanced T1W MRI...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27907862/alteration-of-%C3%AE-n-acetylgalactosaminidase-nagalase-concentration-in-alcohol-dependent-individuals-without-liver-disease-during-the-detoxification-therapy
#14
Margarita Zoga, Thomas Nikou, Anastasios Ioannidis, Elias Tzavellas, Thomas Paparrigopoulos, Konstantinos Th Lambrokostopoulos, Vassilis G Vasdekis, Maria Magana, Stylianos Chatzipanagiotou
BACKGROUND: The present study aimed to investigate for the first time, the alteration of α-N-acetylgalactosaminidase (nagalase) concentration in alcohol-dependent individuals without liver disease, before, during and at the end of the detoxification therapy. METHODS: Forty-eight alcohol-dependent individuals without liver disease who were admitted for alcohol detoxification, and eighty-four healthy controls participated in this study. Patients' blood was obtained upon admission, two weeks later and after the completion of the detoxification period (4-5 weeks)...
January 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27899580/orthodb-v9-1-cataloging-evolutionary-and-functional-annotations-for-animal-fungal-plant-archaeal-bacterial-and-viral-orthologs
#15
Evgeny M Zdobnov, Fredrik Tegenfeldt, Dmitry Kuznetsov, Robert M Waterhouse, Felipe A Simão, Panagiotis Ioannidis, Mathieu Seppey, Alexis Loetscher, Evgenia V Kriventseva
OrthoDB is a comprehensive catalog of orthologs, genes inherited by extant species from a single gene in their last common ancestor. In 2016 OrthoDB reached its 9th release, growing to over 22 million genes from over 5000 species, now adding plants, archaea and viruses. In this update we focused on usability of this fast-growing wealth of data: updating the user and programmatic interfaces to browse and query the data, and further enhancing the already extensive integration of available gene functional annotations...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27896967/methods-to-ensure-the-reproducibility-of-biomedical-research
#16
Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis
Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27884869/sex-based-subgroup-differences-in-randomized-controlled-trials-empirical-evidence-from-cochrane-meta-analyses
#17
Joshua D Wallach, Patrick G Sullivan, John F Trepanowski, Ewout W Steyerberg, John P A Ioannidis
OBJECTIVE:  To evaluate the frequency, validity, and relevance of statistically significant (P<0.05) sex-treatment interactions in randomized controlled trials in Cochrane meta-analyses. DESIGN:  Meta-epidemiological study. DATA SOURCES:  Cochrane Database of Systematic Reviews (CDSR) and PubMed. ELIGIBILITY CRITERIA FOR STUDY SELECTION:  Reviews published in the CDSR with sex-treatment subgroup analyses in the forest plots, using data from randomized controlled trials...
November 24, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27884175/network-meta-analyses-performed-by-contracting-companies-and-commissioned-by-industry
#18
Ewoud Schuit, John Pa Ioannidis
BACKGROUND: Industry commissions contracting companies to perform network meta-analysis for health technology assessment (HTA) and reimbursement submissions. Our objective was to estimate the number of network meta-analyses performed by consulting companies contracted by industry, to assess whether they were published, and to explore reasons for non-publication. METHODS: We searched MEDLINE for network meta-analyses of randomized trials. Papers were included if they had authors affiliated with any contracting company...
November 25, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27882536/brca1-and-brca2-mutation-testing-in-cyprus-a-population-based-study
#19
M A Loizidou, A Hadjisavvas, P Pirpa, E Spanou, T Delikurt, G A Tanteles, M Daniel, P Kountourakis, S Malas, G Ioannidis, I Zouvani, E Kakouri, D Papamichael, Y Marcou, V Anastasiadou, K Kyriacou
This paper presents the largest study in Cyprus evaluating the frequency and distribution of BRCA1/2 mutations in a high risk patient cohort. Deleterious mutations in the BRCA1/2 genes were identified in 68 of the 527 patients tested (13%). It is of interest that a quarter of those tested positive, did not have an extensive family history of breast/ovarian cancer but were diagnosed with early onset breast cancer, ovarian cancer under the age of 60 or triple negative breast cancer. The spectrum of mutations identified in our patient cohort is different compared to other Mediterranean countries...
October 13, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27866903/emerging-concepts-in-t-follicular-helper-cell-responses-to-malaria
#20
REVIEW
Diana S Hansen, Nyamekye Obeng-Adjei, Ann Ly, Lisa J Ioannidis, Peter D Crompton
Antibody responses to malaria and candidate malaria vaccines are short-lived in children, leaving them susceptible to repeated malaria episodes. Because T follicular helper (TFH) cells provide critical help to B cells to generate long-lived antibody responses, they have become the focus of recent studies of Plasmodium-infected mice and humans. The emerging data converge on common themes, namely, that malaria-induced TH1 cytokines are associated with the activation of (i) T-like memory TFH cells with impaired B cell helper function, and (ii) pre-TFH cells that acquire Th1-like features (T-bet expression, IFN-γ production), which impede their differentiation into fully functional TFH cells, thus resulting in germinal center dysfunction and suboptimal antibody responses...
November 17, 2016: International Journal for Parasitology
keyword
keyword
13715
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"