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https://www.readbyqxmd.com/read/28207736/congenital-toxoplasmosis-in-france-and-the-united-states-one-parasite-two-diverging-approaches
#1
Francois Peyron, Rima Mc Leod, Daniel Ajzenberg, Despina Contopoulos-Ioannidis, François Kieffer, Laurent Mandelbrot, L David Sibley, Hervé Pelloux, Isabelle Villena, Martine Wallon, Jose G Montoya
No abstract text is available yet for this article.
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28196819/outcome-reporting-bias-in-clinical-trials-why-monitoring-matters
#2
John Pa Ioannidis, Arthur L Caplan, Rafael Dal-Ré
No abstract text is available yet for this article.
February 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28192565/acknowledging-and-overcoming-nonreproducibility-in-basic-and-preclinical-research
#3
John P A Ioannidis
No abstract text is available yet for this article.
February 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28192563/evaluation-of-evidence-of-statistical-support-and-corroboration-of-subgroup-claims-in-randomized-clinical-trials
#4
Joshua D Wallach, Patrick G Sullivan, John F Trepanowski, Kristin L Sainani, Ewout W Steyerberg, John P A Ioannidis
Importance: Many published randomized clinical trials (RCTs) make claims for subgroup differences. Objective: To evaluate how often subgroup claims reported in the abstracts of RCTs are actually supported by statistical evidence (P < .05 from an interaction test) and corroborated by subsequent RCTs and meta-analyses. Data Sources: This meta-epidemiological survey examines data sets of trials with at least 1 subgroup claim, including Subgroup Analysis of Trials Is Rarely Easy (SATIRE) articles and Discontinuation of Randomized Trials (DISCO) articles...
February 13, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28191679/a-systematic-review-of-the-survival-and-complication-rates-of-resin-bonded-fixed-dental-prostheses-after-a-mean-observation-period-of-at-least-5%C3%A2-years
#5
REVIEW
Daniel S Thoma, Irena Sailer, Alexis Ioannidis, Marcel Zwahlen, Nikolay Makarov, Bjarni E Pjetursson
OBJECTIVES: The objective of this systematic review was to assess the 5-year and 10-year survival of resin-bonded fixed dental prostheses (RBBs) and to describe the incidence of technical and biological complications. MATERIALS AND METHODS: An electronic MEDLINE search complemented by manual searching was conducted to identify prospective and retrospective cohort studies and case series on RBBs with a mean follow-up time of at least 5 years. Patients had to have been examined clinically at the follow-up visit...
February 13, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28190627/does-evidence-based-hearsay-determine-the-use-of-medical-treatments
#6
John P A Ioannidis
No abstract text is available yet for this article.
February 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28187594/nuclear-markers-support-the-mitochondrial-phylogeny-of-i-vipera-i-i-ursinii-renardi-i-complex-squamata-viperidae-and-species-status-for-the-greek-meadow-viper
#7
Edvárd Mizsei, Daniel Jablonski, Stephanos A Roussos, Maria Dimaki, Yannis Ioannidis, Göran Nilson, Zoltán T Nagy
Meadow vipers (Vipera ursinii-renardi complex) are small-bodied snakes that live in either lowland grasslands or montane subalpine-alpine meadows spanning a distribution from France to western China. This complex has previously been the focus of several taxonomic studies which were based mainly on morphological, allozyme or immunological characters and did not clearly resolve the relationships between the various taxa. Recent mitochondrial DNA analyses found unexpected relationships within the complex which had taxonomical consequences for the detected lineages...
January 31, 2017: Zootaxa
https://www.readbyqxmd.com/read/28185865/cutaneous-squamous-cell-cancer-cscc-risk-and-the-human-leukocyte-antigen-hla-system
#8
REVIEW
Pooja Yesantharao, Wei Wang, Nilah M Ioannidis, Shadmehr Demehri, Alice S Whitemore, Maryam M Asgari
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer among Caucasians in the United States, with rising incidence over the past decade. Treatment for non-melanoma skin cancer, including cSCC, in the United States was estimated to cost $4.8 billion in 2014. Thus, an understanding of cSCC pathogenesis could have important public health implications. Immune function impacts cSCC risk, given that cSCC incidence rates are substantially higher in patients with compromised immune systems. We report a systematic review of published associations between cSCC risk and the human leukocyte antigen (HLA) system...
February 6, 2017: Human Immunology
https://www.readbyqxmd.com/read/28182641/stress-indicator-gene-expression-profiles-colony-dynamics-and-tissue-development-of-honey-bees-exposed-to-sub-lethal-doses-of-imidacloprid-in-laboratory-and-field-experiments
#9
Lina De Smet, Fani Hatjina, Pavlos Ioannidis, Anna Hamamtzoglou, Karel Schoonvaere, Frédéric Francis, Ivan Meeus, Guy Smagghe, Dirk C de Graaf
In this study, different context-dependent effects of imidacloprid exposure on the honey bee response were studied. Honey bees were exposed to different concentrations of imidacloprid during a time period of 40 days. Next to these variables, a laboratory-field comparison was conducted. The influence of the chronic exposure on gene expression levels was determined using an in-house developed microarray targeting different immunity-related and detoxification genes to determine stress-related gene expression changes...
2017: PloS One
https://www.readbyqxmd.com/read/28143598/diet-life-style-and-cardiovascular-morbidity-in-the-rural-free-living-population-of-elafonisos-island
#10
Chris J Kapelios, Ioannis Kyriazis, Ioannis Ioannidis, Charilaos Dimosthenopoulos, Erifili Hatziagelaki, Stavros Liatis
BACKGROUND: There are about 70 small islands in the Aegean and Ionian Sea, of less than 300 Km(2) and 5000 inhabitants each, comprising a total population of more than 75,000 individuals with geographical and socioeconomic characteristics of special interest. The objective of the present study was to assess lifestyle characteristics and the state of cardiovascular risk of the population of a small Eastern Mediterranean island, Elafonisos. METHODS: PERSEAS (Prospective Evaluation of cardiovascular Risk Surrogates in Elafonisos Area Study) is an ongoing, population-based, longitudinal survey of cardiovascular risk factors, life-style characteristics and related morbidity/mortality performed in a small and relatively isolated island of the Aegean Sea, named Elafonisos...
February 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28137743/genomic-features-of-the-damselfly-calopteryx-splendens-representing-a-sister-clade-to-most-insect-orders
#11
Panagiotis Ioannidis, Felipe A Simao, Robert M Waterhouse, Mosè Manni, Mathieu Seppey, Hugh M Robertson, Bernhard Misof, Oliver Niehuis, Evgeny M Zdobnov
Insects comprise the most diverse and successful animal group with over one million described species that are found in almost every terrestrial and limnic habitat, with many being used as important models in genetics, ecology, and evolutionary research. Genome sequencing projects have greatly expanded the sampling of species from many insect orders, but genomic resources for species of certain insect lineages have remained relatively limited to date. To address this paucity, we sequenced the genome of the banded demoiselle, Calopteryx splendens, a damselfly (Odonata: Zygoptera) belonging to Palaeoptera, the clade containing the first winged insects...
January 30, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28128334/protein-kinase-c-%C3%AE-a-new-target-therapy-to-prevent-the-long-term-atypical-antipsychotics-induced-weight-gain
#12
Alessandro Rimessi, Chiara Pavan, Elli Ioannidi, Federica Nigro, Claudia Morganti, Alberto Brugnoli, Francesco Longo, Chiara Gardin, Letizia Ferroni, Michele Morari, Vincenzo Vindigni, Barbara Zavan, Paolo Pinton
Antipsychotic drugs are currently used in clinical practice for a variety of mental disorders. Among them, clozapine is the most effective medication for treatment-resistant schizophrenia and is most helpful in controlling aggression and the suicidal behavior in schizophrenia and schizoaffective disorder. Although clozapine is associated with a low likelihood of extrapyramidal symptoms and other neurological side effects, it is well-known for the weight gain and metabolic side effects, which expose the patient to a greater risk of cardiovascular disorders, premature death, as well as psychosocial issues leading to non-adherence to therapy...
January 27, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28127782/finding-the-power-to-reduce-publication-bias
#13
T D Stanley, Hristos Doucouliagos, John P A Ioannidis
The central purpose of this study is to document how a sharper focus upon statistical power may reduce the impact of selective reporting bias in meta-analyses. We introduce the weighted average of the adequately powered (WAAP) as an alternative to the conventional random-effects (RE) estimator. When the results of some of the studies have been selected to be positive and statistically significant (i.e. selective reporting), our simulations show that WAAP will have smaller bias than RE at no loss to its other statistical properties...
January 27, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28125982/an-overview-of-osteoporosis-and-frailty-in-the-elderly
#14
REVIEW
Guowei Li, Lehana Thabane, Alexandra Papaioannou, George Ioannidis, Mitchell A H Levine, Jonathan D Adachi
Osteoporosis and osteoporotic fractures remain significant public health challenges worldwide. Recently the concept of frailty in relation to osteoporosis in the elderly has been increasingly accepted, with emerging studies measuring frailty as a predictor of osteoporotic fractures. In this overview, we reviewed the relationship between frailty and osteoporosis, described the approaches to measuring the grades of frailty, and presented current studies and future research directions investigating osteoporosis and frailty in the elderly...
January 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28122319/a-rare-cause-for-hartmann-s-procedure-due-to-biliary-stent-migration-a-case-report
#15
Petros Siaperas, Argyrios Ioannidis, Andreas Skarpas, Argiris Angelopoulos, Ioannis Drikos, Ioannis Karanikas
INTRODUCTION: Biliary stent migration (proximal or distal) occurs in 6% of all cases. The majority of these migrating stents are passing through the intestine, without causing any complications. Usually when a stent migration occurs, endoscopic retrieval is the proper treatment option, except in case of complications when surgical removal is the only treatment option. This report presents a case of a biliary stent which migrated and caused a sigmoid colon perforation. PRESENTATION OF CASE: A 75 years old female patient presented to the emergency department with diffuse abdominal pain, nausea and vomiting...
January 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28114549/underperforming-big-ideas-in-biomedical-research-reply
#16
LETTER
Michael J Joyner, Nigel Paneth, John P A Ioannidis
No abstract text is available yet for this article.
17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28108205/modifying-the-phenotypic-frailty-model-in-predicting-risk-of-major-osteoporotic-fracture-in-the-elderly
#17
Guowei Li, Alexandra Papaioannou, Lehana Thabane, Mitchell A H Levine, George Ioannidis, Andy K O Wong, Arthur Lau, Jonathan D Adachi
INTRODUCTION: The phenotypic frailty (PF) model (including slow walking, low physical activity, exhaustion, weakness, and unintentional weight loss) has been widely used to quantify the degree of frailty and predict risks of adverse health outcomes for the elderly. However, evidence has shown that not all the components included in the PF model contribute equally, and low predictive accuracy of the PF model has been reported in predicting risks of outcomes. We aimed to improve predictive accuracy of the PF model in risk of major osteoporotic fracture (MOF) in the elderly by modifying its weighting of individual components...
January 17, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28077235/drivers-of-poor-medical-care
#18
REVIEW
Vikas Saini, Sandra Garcia-Armesto, David Klemperer, Valerie Paris, Adam G Elshaug, Shannon Brownlee, John P A Ioannidis, Elliott S Fisher
The global ubiquity of overuse and underuse of health-care resources and the gravity of resulting harms necessitate an investigation of drivers to inform potential solutions. We describe the network of influences that contribute to poor care and suggest that it is driven by factors that fall into three domains: money and finance; knowledge, bias, and uncertainty; and power and human relationships. In each domain the drivers operate at the global, national, regional, and individual level, and are modulated by the specific contexts within which they act...
January 6, 2017: Lancet
https://www.readbyqxmd.com/read/28073328/what-constitutes-strong-psychological-science-the-neglected-role-of-diagnosticity-and-a-priori-theorizing
#19
Klaus Fiedler
A Bayesian perspective on Ioannidis's (2005) memorable statement that "Most Published Research Findings Are False" suggests a seemingly inescapable trade-off: It appears as if research hypotheses are based either on safe ground (high prior odds), yielding valid but unsurprising results, or on unexpected and novel ideas (low prior odds), inspiring risky and surprising findings that are inevitably often wrong. Indeed, research of two prominent types, sexy hypothesis testing and model testing, is often characterized by low priors (due to astounding hypotheses and conjunctive models) as well as low-likelihood ratios (due to nondiagnostic predictions of the yin-or-yang type)...
January 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28059518/ligand-field-dependent-behavior-of-meta-gga-exchange-in-transition-metal-complex-spin-state-ordering
#20
Efthymios I Ioannidis, Heather J Kulik
Prediction of spin-state ordering in transition metal complexes is essential for understanding catalytic activity and designing functional materials. Semilocal approximations in density functional theory, such as the generalized-gradient approximation (GGA), suffer from several errors including delocalization error that give rise to systematic bias for more covalently bound low-spin electronic states. Incorporation of exact exchange is known to counteract this bias, instead favoring high-spin states, in a manner that has recently been identified to be strongly ligand-field dependent...
January 23, 2017: Journal of Physical Chemistry. A
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