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https://www.readbyqxmd.com/read/28918053/ush2a-gene-editing-using-the-crispr-system
#1
Carla Fuster-García, Gema García-García, Elisa González-Romero, Teresa Jaijo, María D Sequedo, Carmen Ayuso, Rafael P Vázquez-Manrique, José M Millán, Elena Aller
Usher syndrome (USH) is a rare autosomal recessive disease and the most common inherited form of combined visual and hearing impairment. Up to 13 genes are associated with this disorder, with USH2A being the most prevalent, due partially to the recurrence rate of the c.2299delG mutation. Excluding hearing aids or cochlear implants for hearing impairment, there are no medical solutions available to treat USH patients. The repair of specific mutations by gene editing is, therefore, an interesting strategy that can be explored using the CRISPR/Cas9 system...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28917133/waiting-for-lexical-access-cochlear-implants-or-severely-degraded-input-lead-listeners-to-process-speech-less-incrementally
#2
Bob McMurray, Ashley Farris-Trimble, Hannah Rigler
Spoken language unfolds over time. Consequently, there are brief periods of ambiguity, when incomplete input can match many possible words. Typical listeners solve this problem by immediately activating multiple candidates which compete for recognition. In two experiments using the visual world paradigm, we examined real-time lexical competition in prelingually deaf cochlear implant (CI) users, and normal hearing (NH) adults listening to severely degraded speech. In Experiment 1, adolescent CI users and NH controls matched spoken words to arrays of pictures including pictures of the target word and phonological competitors...
September 13, 2017: Cognition
https://www.readbyqxmd.com/read/28906240/listening-effort-measured-in-adults-with-normal-hearing-and-cochlear-implants
#3
Ann E Perreau, Yu-Hsiang Wu, Bailey Tatge, Diana Irwin, Daniel Corts
BACKGROUND: Studies have examined listening effort in individuals with hearing loss to determine the extent of the impairment. Regarding cochlear implants (CIs), results suggest that listening effort is improved using bilateral CIs compared to unilateral CIs. Few studies have investigated listening effort and outcomes related to the hybrid CI. PURPOSE: Here, we compared listening effort across three CI groups, and to a normal-hearing control group. The impact of listener traits, that is, age, age at onset of hearing loss, duration of CI use, and working memory capacity, were examined relative to listening effort...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28906160/tone-production-and-perception-and-intelligibility-of-produced-speech-in-mandarin-speaking-cochlear-implanted-children
#4
Yi-Lu Li, Yi-Hui Lin, Hui-Mei Yang, Yeou-Jiunn Chen, Jiunn-Liang Wu
OBJECTIVE: This study explored tone production, tone perception and intelligibility of produced speech in Mandarin-speaking prelingually deaf children with at least 5 years of cochlear implant (CI) experience. Another focus was on the predictive value of tone perception and tone production as they relate to speech intelligibility. DESIGN: Cross-sectional research. STUDY SAMPLE: Thirty-three prelingually deafened children aged over eight years with over five years of experience with CI underwent tests for tone perception, tone production, and the Speech Intelligibility Rating (SIR)...
September 14, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28902805/the-effect-of-hearing-aids-and-cochlear-implants-on-balance-during-gait
#5
Tyler S Weaver, Corey S Shayman, Timothy E Hullar
HYPOTHESIS: Auditory input in people with hearing impairment will improve balance while walking. BACKGROUND: Auditory input is increasingly recognized as an additional input for balance. Several studies have found auditory cues to improve static balance measured on a sway platform. The effect of audition on gait, a dynamic task also linked to fall risk, has not been fully examined. If a positive effect were shown between audition and balance, it would further indicate that improving hearing could also improve balance...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28902803/cochlear-implantation-in-otosclerosis-surgical-and-auditory-outcomes-with-a-brief-on-facial-nerve-stimulation
#6
Ashish Vashishth, Andrea Fulcheri, Gianluca Rossi, Sampath Chandra Prasad, Antonio Caruso, Mario Sanna
OBJECTIVES: 1) To review the surgical and auditory outcomes in patients of cochlear implantation in otosclerosis. 2) To review complications and postimplantation facial nerve stimulation (FNS). 3) To compare the auditory outcomes between patients displaying cochlear ossification to the nonossified ones. STUDY DESIGN: Retrospective study. SETTING: Quaternary Otology and Skull base surgery center. SUBJECTS AND METHODS: Charts of 36 patients (38 ears) with otosclerosis undergoing cochlear implantation were reviewed from the cochlear implant database...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28902802/audiological-outcomes-and-map-characteristics-in-children-with-perimodiolar-and-slim-straight-array-cochlear-implants-in-opposite-ears
#7
Lisa R Park, Holly F B Teagle, Kevin D Brown, Erika B Gagnon, Jennifer S Woodard, Craig A Buchman
OBJECTIVE: To identify differences in outcomes and map characteristics in pediatric bilateral cochlear implants with modiolar conforming and lateral wall arrays in opposite ears. STUDY DESIGN: Retrospective case series. SETTING: Tertiary care pediatric referral center. PATIENTS: Fourteen children who received a perimodiolar array in one ear and a slim straight array in the opposite ear in sequential surgeries. INTERVENTIONS: None...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28901574/using-a-multi-feature-paradigm-to-measure-mismatch-responses-to-minimal-sound-contrasts-in-children-with-cochlear-implants-and-hearing-aids
#8
Inger Uhlén, Elisabet Engström, Petter Kallioinen, Cecilia Nakeva von Mentzer, Björn Lyxell, Birgitta Sahlén, Magnus Lindgren, Marianne Ors
Our aim was to explore whether a multi-feature paradigm (Optimum-1) for eliciting mismatch negativity (MMN) would objectively capture difficulties in perceiving small sound contrasts in children with hearing impairment (HI) listening through their hearing aids (HAs) and/or cochlear implants (CIs). Children aged 5-7 years with HAs, CIs and children with normal hearing (NH) were tested in a free-field setting using a multi-feature paradigm with deviations in pitch, intensity, gap, duration, and location. There were significant mismatch responses across all subjects that were positive (p-MMR) for the gap and pitch deviants (F(1,43) = 5...
October 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28900873/numerical-analysis-of-intracochlear-mechanical-auditory-stimulation-using-piezoelectric-bending-actuators
#9
Daniel Schurzig, Sebastian Schwarzendahl, Jörg Wallaschek, Wouter J van Drunen, Thomas S Rau, Thomas Lenarz, Omid Majdani
Cochlear implantation can restore a certain degree of auditory impression of patients suffering from profound hearing loss or deafness. Furthermore, studies have shown that in case of residual hearing, patients benefit from the use of a hearing aid in addition to the cochlear implant. The presented studies aim at the improvement of this electromechanical stimulation (EMS) approach by substituting the external hearing aid by an internal stimulus provided by miniaturized piezoelectric actuators. Finite element analyses are performed in order to derive fundamental guidelines for the actuator layout aiming at maximal mechanical stimuli...
September 13, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28899200/spoken-language-and-everyday-functioning-in-5-year-old-children-using-hearing-aids-or-cochlear-implants
#10
Linda Cupples, Teresa Yc Ching, Laura Button, Mark Seeto, Vicky Zhang, Jessica Whitfield, Miriam Gunnourie, Louise Martin, Vivienne Marnane
OBJECTIVE: This study investigated the factors influencing 5-year language, speech and everyday functioning of children with congenital hearing loss. DESIGN: Standardised tests including PLS-4, PPVT-4 and DEAP were directly administered to children. Parent reports on language (CDI) and everyday functioning (PEACH) were collected. Regression analyses were conducted to examine the influence of a range of demographic variables on outcomes. STUDY SAMPLE: Participants were 339 children enrolled in the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study...
September 12, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28895463/impact-of-primary-language-and-insurance-on-pediatric-hearing-health-care-in-a-multidisciplinary-clinic
#11
Brooke M Su, Jason S Park, Dylan K Chan
Objective This study aims to describe the effects of primary language and insurance status on care utilization among deaf or hard-of-hearing children under active otolaryngologic and audiologic care. Study Design Cross-sectional analysis. Setting Multidisciplinary hearing loss clinic at a tertiary center. Subjects and Methods Demographics, hearing loss data, and validated survey responses were collected from 206 patients aged 0 to 19 years. Two-sided t tests and χ(2) tests were used to obtain descriptive statistics and hypothesis testing...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28894831/assessment-and-improvement-of-sound-quality-in-cochlear-implant-users
#12
REVIEW
Meredith T Caldwell, Nicole T Jiam, Charles J Limb
OBJECTIVES: Cochlear implants (CIs) have successfully provided speech perception to individuals with sensorineural hearing loss. Recent research has focused on more challenging acoustic stimuli such as music and voice emotion. The purpose of this review is to evaluate and describe sound quality in CI users with the purposes of summarizing novel findings and crucial information about how CI users experience complex sounds. DATA SOURCES: Here we review the existing literature on PubMed and Scopus to present what is known about perceptual sound quality in CI users, discuss existing measures of sound quality, explore how sound quality may be effectively studied, and examine potential strategies of improving sound quality in the CI population...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894813/the-importance-of-electrode-location-in-cochlear-implantation
#13
REVIEW
Brendan P O'Connell, Jacob B Hunter, George B Wanna
OBJECTIVES: As indications for cochlear implantation have expanded to include patients with more residual hearing, increasing emphasis has been placed on minimally traumatic electrode insertion. Histopathologic evaluation remains the gold standard for evaluation of cochlear trauma, but advances in imaging techniques have allowed clinicians to determine scalar electrode location in vivo. This review will examine the relationship between scalar location of electrode arrays and audiologic outcomes...
December 2016: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28892270/biomimetic-artificial-basilar-membranes-for-next-generation-cochlear-implants
#14
REVIEW
Jongmoon Jang, Jeong Hun Jang, Hongsoo Choi
Patients with sensorineural hearing loss can recover their hearing using a cochlear implant (CI). However, there is a need to develop next-generation CIs to overcome the limitations of conventional CIs caused by extracorporeal devices. Recently, artificial basilar membranes (ABMs) are actively studied for next-generation CIs. The ABM is an acoustic transducer that mimics the mechanical frequency selectivity of the BM and acoustic-to-electrical energy conversion of hair cells. This paper presents recent progress in biomimetic ABMs...
September 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28890230/is-there-a-best-side-for-cochlear-implants-in-post-lingual-patients
#15
Maria Stella Arantes do Amaral, Thiago A Damico, Alina S Gonçales, Ana C M B Reis, Myriam de Lima Isaac, Eduardo T Massuda, Miguel Angelo Hyppolito
INTRODUCTION: Cochlear Implant is a sensory prosthesis capable of restoring hearing in patients with severe or profound bilateral sensorineural hearing loss. OBJECTIVE: To evaluate if there is a better side to be implanted in post-lingual patients. METHODS: Retrospective longitudinal study. Participants were 40 subjects, of both sex, mean age of 47 years, with post-lingual hearing loss, users of unilateral cochlear implant for more than 12 months and less than 24 months, with asymmetric auditor reserve between the ears (difference of 10dBNA, In at least one of the frequencies with a response, between the ears), divided into two groups...
July 29, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28889786/implantable-microphones-as-an-alternative-to-external-microphones-for-cochlear-implants
#16
Alistair Mitchell-Innes, Robert Morse, Richard Irving, Philip Begg
Totally implantable cochlear implants may be able to address many of the problems cochlear implant users have around cosmetic appearances, discomfort, and restriction of activities. The major technological challenges that need to be solved to develop a totally implantable device relate to implanted microphone performance. Previous attempts at implanting microphones for cochlear implants have not performed as well as conventional cochlear implant microphones, and in addition have struggled with extraneous body or surface contact noise...
September 11, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28886405/emotional-recognition-of-dynamic-facial-expressions-before-and-after-cochlear-implantation-in-adults-with-progressive-deafness
#17
Emmanuèle Ambert-Dahan, Anne-Lise Giraud, Halima Mecheri, Olivier Sterkers, Isabelle Mosnier, Séverine Samson
Visual processing has been extensively explored in deaf subjects in the context of verbal communication, through the assessment of speech reading and sign language abilities. However, little is known about visual emotional processing in adult progressive deafness, and after cochlear implantation. The goal of our study was thus to assess the influence of acquired post-lingual progressive deafness on the recognition of dynamic facial emotions that were selected to express canonical fear, happiness, sadness, and anger...
August 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/28885638/speech-recognition-and-cognitive-skills-in-bimodal-cochlear-implant-users
#18
Håkan Hua, Björn Johansson, Lennart Magnusson, Björn Lyxell, Rachel J Ellis
Purpose: To examine the relation between speech recognition and cognitive skills in bimodal cochlear implant (CI) and hearing aid users. Method: Seventeen bimodal CI users (28-74 years) were recruited to the study. Speech recognition tests were carried out in quiet and in noise. The cognitive tests employed included the Reading Span Test and the Trail Making Test (Daneman & Carpenter, 1980; Reitan, 1958, 1992), measuring working memory capacity and processing speed and executive functioning, respectively...
September 8, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28885234/assessing-the-relationship-between-the-electrically-evoked-compound-action-potential-and-speech-recognition-abilities-in-bilateral-cochlear-implant-recipients
#19
Kara C Schvartz-Leyzac, Bryan E Pfingst
OBJECTIVES: The primary objective of the present study was to examine the relationship between suprathreshold electrically evoked compound action potential (ECAP) measures and speech recognition abilities in bilateral cochlear implant listeners. We tested the hypothesis that the magnitude of ear differences in ECAP measures within a subject (right-left) could predict the difference in speech recognition performance abilities between that subject's ears (right-left). DESIGN: To better control for across-subject variables that contribute to speech understanding, the present study used a within-subject design...
September 6, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28885072/programming-characteristics-of-cochlear-implants-in-children-effects-of-aetiology-and-age-at-implantation
#20
Paola V Incerti, Teresa Y C Ching, Sanna Hou, Patricia Van Buynder, Christopher Flynn, Robert Cowan
OBJECTIVE: We investigated effects of aetiology and age at implantation on changes in threshold (T) levels, comfortable (C) levels and dynamic range (DR) for cochlear implants (CIs) in children over the first five years of life. DESIGN: Information was collected at 6 months post-activation of CIs, and at 3 and 5 years of age. STUDY SAMPLE: One hundred and sixty-one children participating in the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study...
September 8, 2017: International Journal of Audiology
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