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https://www.readbyqxmd.com/read/29776736/trabecular-bone-score-at-the-distal-femur-and-proximal-tibia-in-individuals-with-spinal-cord-injury
#1
Stacey Lobos, Anne Cooke, Gillian Simonett, Chester Ho, Steven K Boyd, W Brent Edwards
Rapid declines in bone mineral density (BMD) at the knee after spinal cord injury (SCI) are associated with an increased risk of fracture. Evaluation of bone quality using the trabecular bone score (TBS) may provide a complimentary measure to BMD assessment to examine bone health and fracture risk after SCI. The purpose of this study was to assess bone mineral density (BMD) and trabecular bone score (TBS) at the knee in individuals with and without SCI. Nine individuals with complete SCI (mean time since SCI 2...
April 24, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29771751/utility-of-optical-coherence-tomography-in-the-evaluation-of-sellar-and-parasellar-mass-lesions
#2
Omar Al-Louzi, Sashank Prasad, Robert M Mallery
PURPOSE OF REVIEW: Anterior visual pathway compression is a common feature of sellar region masses. We review the visual pathway neuroanatomy pertaining to sellar and parasellar lesions and describe recent advances in optical coherence tomography (OCT) imaging that have provided a novel quantitative perspective in the evaluation and management of such patients. RECENT FINDINGS: Ultrastructural measurements of optic nerve integrity using OCT, namely peripapillary retinal nerve fiber layer (pRNFL) and the ganglion cell and inner plexiform layer (GCIPL) thicknesses, have been shown to correlate with visual acuity and visual field deficits on perimetry in patients with compressive sellar region masses...
May 15, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29768498/genomic-variants-in-an-inbred-mouse-model-predict-mania-like-behaviors
#3
Michael C Saul, Sharon A Stevenson, Changjiu Zhao, Terri M Driessen, Brian E Eisinger, Stephen C Gammie
Contemporary rodent models for bipolar disorders split the bipolar spectrum into complimentary behavioral endophenotypes representing mania and depression. Widely accepted mania models typically utilize single gene transgenics or pharmacological manipulations, but inbred rodent strains show great potential as mania models. Their acceptance is often limited by the lack of genotypic data needed to establish construct validity. In this study, we used a unique strategy to inexpensively explore and confirm population allele differences in naturally occurring candidate variants in a manic rodent strain, the Madison (MSN) mouse strain...
2018: PloS One
https://www.readbyqxmd.com/read/29764364/efficient-algorithms-for-polyploid-haplotype-phasing
#4
Dan He, Subrata Saha, Richard Finkers, Laxmi Parida
BACKGROUND: Inference of haplotypes, or the sequence of alleles along the same chromosomes, is a fundamental problem in genetics and is a key component for many analyses including admixture mapping, identifying regions of identity by descent and imputation. Haplotype phasing based on sequencing reads has attracted lots of attentions. Diploid haplotype phasing where the two haplotypes are complimentary have been studied extensively. In this work, we focused on Polyploid haplotype phasing where we aim to phase more than two haplotypes at the same time from sequencing data...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29760644/an-algorithm-for-preclinical-diagnosis-of-alzheimer-s-disease
#5
REVIEW
Tapan K Khan
Almost all Alzheimer's disease (AD) therapeutic trials have failed in recent years. One of the main reasons for failure is due to designing the disease-modifying clinical trials at the advanced stage of the disease when irreversible brain damage has already occurred. Diagnosis of the preclinical stage of AD and therapeutic intervention at this phase, with a perfect target, are key points to slowing the progression of the disease. Various AD biomarkers hold enormous promise for identifying individuals with preclinical AD and predicting the development of AD dementia in the future, but no single AD biomarker has the capability to distinguish the AD preclinical stage...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29748206/deep-learning-convolutional-neural-networks-accurately-classify-genetic-mutations-in-gliomas
#6
P Chang, J Grinband, B D Weinberg, M Bardis, M Khy, G Cadena, M-Y Su, S Cha, C G Filippi, D Bota, P Baldi, L M Poisson, R Jain, D Chow
BACKGROUND AND PURPOSE: The World Health Organization has recently placed new emphasis on the integration of genetic information for gliomas. While tissue sampling remains the criterion standard, noninvasive imaging techniques may provide complimentary insight into clinically relevant genetic mutations. Our aim was to train a convolutional neural network to independently predict underlying molecular genetic mutation status in gliomas with high accuracy and identify the most predictive imaging features for each mutation...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29746545/the-importance-of-artificial-wetlands-for-birds-a-case-study-from-cyprus
#7
Efthymia Giosa, Christos Mammides, Savvas Zotos
The degradation of natural wetlands has significant effects on the ecosystem services they provide and the biodiversity they sustain. Under certain conditions, these negative effects can be mitigated by the presence of artificial wetlands. However, the conservation value of artificial wetlands needs to be explored further. In addition, it is unclear how certain anthropogenic variables, such as road networks and hunting reserves (i.e., areas where hunting of birds is prohibited) affect biodiversity in both artificial and natural wetlands...
2018: PloS One
https://www.readbyqxmd.com/read/29743852/n1-benzenesulfonyl-2-pyrazoline-hybrids-in-neurological-disorders-syntheses-biological-screening-and-computational-studies
#8
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t ) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, applying conventional and green chemistry approaches. Among the two, microwave assisted organic synthesis (MAOS) emerged as a better synthetic tool in terms of faster reaction rate and high yield. Various physicochemical and spectral studies were conducted to characterize the synthesized derivatives including- IR, Mass, 1 H-NMR, 13 C-NMR and elemental analysis...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29730547/time-course-transcriptome-analysis-of-medullary-thymic-epithelial-cells-in-the-early-phase-of-thymic-involution
#9
Haoming Wu, Xiaodan Qin, Hui Dai, Yu Zhang
Degeneration of the thymic epithelium is believed to be the primary cause of age-associated thymic involution. In order to investigate the molecular events during the early phase of thymic involution, RNA-seq was performed to gain the transcriptional profiles of medullary thymic epithelial cells (mTEC) from mice of 2, 6 and 10 weeks of age. We confirmed and extended the previous observation of declined expression of cell cycle-related genes and diminished E2F3 activity during thymic involution, showing that it occurred as early as 2-6 weeks after birth...
May 3, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29729108/high-prevalence-of-anemia-in-10-month-old-japanese-infants-with-breastfeeding
#10
Masahiko Kimura, Youichi Kurozawa, Yumi Saito, Hiroshi Watanabe, Ayame Kobayashi, Takeshi Taketani
BACKGROUND: Anemia in infancy is still prevalent in developing countries. Commercial iron-fortified complementary foods or iron drops are not available in Japan and breastfed infants have a higher risk of anemia. We studied anemia screening in infants in 10-month old infants and evaluated whether breastfeeding is a risk factor for anemia. METHODS: Anemia screening was performed during a regular health check of 10-month children at four local pediatric clinics in Shimane prefecture, Japan...
May 5, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29723468/dart-ms-a-new-analytical-technique-for-forensic-paint-analysis
#11
Mark Maric, James Marano, Robert Bernard Cody, Candice Bridge
Automotive paint evidence is one of the most significant forms of evidence obtained in automotive related incidents. Therefore, the analysis of automotive paint evidence is imperative in forensic casework. Most analytical schemes for automotive paint characterization involve optical microscopy, followed by infrared spectroscopy and pyrolysis-gas chromatography mass spectrometry (py-GCMS) if required. The main drawback with py-GCMS aside from its destructive nature, is that this technique is relatively time intensive in comparison to other techniques...
May 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29721371/complimentary-mechanisms-of-dual-checkpoint-blockade-expand-unique-t-cell-repertoires-and-activate-adaptive-anti-tumor-immunity-in-triple-negative-breast-tumors
#12
Erika J Crosby, Junping Wei, Xiao Yi Yang, Gangjun Lei, Tao Wang, Cong-Xiao Liu, Pankaj Agarwal, Alan J Korman, Michael A Morse, Kenneth Gouin, Simon R V Knott, H Kim Lyerly, Zachary C Hartman
Triple-negative breast cancer (TNBC) is an aggressive and molecularly diverse breast cancer subtype typified by the presence of p53 mutations (∼80%), elevated immune gene signatures and neoantigen expression, as well as the presence of tumor infiltrating lymphocytes (TILs). As these factors are hypothesized to be strong immunologic prerequisites for the use of immune checkpoint blockade (ICB) antibodies, multiple clinical trials testing single ICBs have advanced to Phase III, with early indications of heterogeneous response rates of <20% to anti-PD1 and anti-PDL1 ICB...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29718076/clinical-neuropsychology-in-integrated-rehabilitation-care-teams
#13
Doug Johnson-Greene
Neuropsychologists have been an integral part of rehabilitation-oriented integrated care teams for some time and they provide care that is complimentary to other specialties, such as rehabilitation psychologists. Neuropsychologists are more likely than other specialties to offer objective cognitive data that includes consideration of emotional and behavioral features when assessing patients who have known or suspected brain injury or illness. Objective cognitive data is then often used for treatment and discharge planning as well as anticipating safety issues and impairment of functional skills...
May 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29715787/depth-and-thermal-sensor-fusion-to-enhance-3d-thermographic-reconstruction
#14
Yanpeng Cao, Baobei Xu, Zhangyu Ye, Jiangxin Yang, Yanlong Cao, Christel-Loic Tisse, Xin Li
Three-dimensional geometrical models with incorporated surface temperature data provide important information for various applications such as medical imaging, energy auditing, and intelligent robots. In this paper we present a robust method for mobile and real-time 3D thermographic reconstruction through depth and thermal sensor fusion. A multimodal imaging device consisting of a thermal camera and a RGB-D sensor is calibrated geometrically and used for data capturing. Based on the underlying principle that temperature information remains robust against illumination and viewpoint changes, we present a Thermal-guided Iterative Closest Point (T-ICP) methodology to facilitate reliable 3D thermal scanning applications...
April 2, 2018: Optics Express
https://www.readbyqxmd.com/read/29706463/characterizing-a-novel-vglut3-p2a-icreer-knockin-mouse-strain-in-cochlea
#15
Chao Li, Yilai Shu, Guangqin Wang, He Zhang, Ying Lu, Xiang Li, Gen Li, Lei Song, Zhiyong Liu
Precise mouse genetic studies rely on specific tools that can label specific cell types. In mouse cochlea, previous studies suggest that vesicular glutamate transporter 3 (vGlut3), also known as Slc17a8, is specifically expressed in inner hair cells (IHCs) and loss of vGlut3 causes deafness. To take advantage of its unique expression pattern, here we generate a novel vGlut3-P2A-iCreER knockin mouse strain. The P2A-iCreER cassette is precisely inserted before stop codon of vGlut3, by which the endogenous vGlut3 is intact and paired with iCreER as well...
April 17, 2018: Hearing Research
https://www.readbyqxmd.com/read/29702296/advances-in-management-of-esophageal-motility-disorders
#16
REVIEW
Peter J Kahrilas, Albert J Bredenoord, Dustin A Carlson, John E Pandolfino
The widespread adoption of high-resolution manometry (HRM) has led to a restructuring in the classification of esophageal motility disorder classification summarized in the Chicago Classification, currently in version 3.0. It has become apparent that the cardinal feature of achalasia, impaired lower esophageal sphincter relaxation, can occur in several disease phenotypes: without peristalsis, with premature (spastic) distal esophageal contractions, with panesophageal pressurization, or even with preserved peristalsis...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29696526/parent-teacher-agreement-on-social-skills-and-behavior-problems-among-ethnically-diverse-preschoolers-with-autism-spectrum-disorder
#17
Brittany Thompson, Adam Winsler
Parents and teachers provide complimentary information in the assessment of preschoolers so it is important to understand parent-teacher agreement, especially for children with autism. Parents and teachers rated an ethnically diverse sample of preschoolers with autism (N = 257; 67% Latino) on the Devereux Early Childhood Assessment (LeBuffe and Naglieri in Devereux Early Childhood Assessment: User's guide, Kaplan Press, Lewisville, 1999). Correlations between parent and teacher ratings were moderate and significant for social skills (r = 0...
April 25, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29696229/total-integrated-performance-excellence-system-tipes-a-true-north-direction-for-a-clinical-trial-support-center
#18
Mike R Sather, Sherry Parsons, Kathy D Boardman, Stuart R Warren, Anne Davis-Karim, Kevin Griffin, Jane A Betterton, Mark S Jones, Stanley H Johnson, Julia E Vertrees, Jan H Hickey, Thelma P Salazar, Grant D Huang
This paper presents the quality journey taken by a Federal organization over more than 20 years. These efforts have resulted in the implementation of a Total Integrated Performance Excellence System (TIPES) that combines key principles and practices of established quality systems. The Center has progressively integrated quality system frameworks including the Malcom Baldrige National Quality Award (MBNQA) Framework and Criteria for Performance Excellence, ISO 9001, and the Organizational Project Management Maturity Model (OPM3), as well as supplemental quality systems of ISO 15378 (packaging for medicinal products) and ISO 21500 (guide to project management) to systematically improve all areas of operations...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29695862/critical-roles-of-trpv2-channels-histamine-h1-and-adenosine-a1-receptors-in-the-initiation-of-acupoint-signals-for-acupuncture-analgesia
#19
Meng Huang, Xuezhi Wang, Beibei Xing, Hongwei Yang, Zheyan Sa, Di Zhang, Wei Yao, Na Yin, Ying Xia, Guanghong Ding
Acupuncture is one of the most promising modalities in complimentary medicine. However, the underlying mechanisms are not well understood yet. We found that in TRPV2 knockout male mice, acupuncture-induced analgesia was suppressed with a decreased activation of mast cells in the acupoints stimulated. The mast cell stabilizer sodium cromolyn could suppress the release of adenosine in the acupoints on male rats. A direct injection of adenosine A1 receptor agonist or histamine H1 receptor agonist increased β-endorphin in the cerebral-spinal fluid in the acute adjuvant arthritis male rats and thus replicated the analgesic effect of acupuncture...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29695294/the-hologenome-concept-of-evolution-after-10-years
#20
REVIEW
Eugene Rosenberg, Ilana Zilber-Rosenberg
The holobiont (host with its endocellular and extracellular microbiome) can function as a distinct biological entity, an additional organismal level to the ones previously considered, on which natural selection operates. The holobiont can function as a whole: anatomically, metabolically, immunologically, developmentally, and during evolution. Consideration of the holobiont with its hologenome as an independent level of selection in evolution has led to a better understanding of underappreciated modes of genetic variation and evolution...
April 25, 2018: Microbiome
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