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https://www.readbyqxmd.com/read/28732065/direct-targets-of-pstat5-signalling-in-erythropoiesis
#1
Kevin R Gillinder, Hugh Tuckey, Charles C Bell, Graham W Magor, Stephen Huang, Melissa D Ilsley, Andrew C Perkins
Erythropoietin (EPO) acts through the dimeric erythropoietin receptor to stimulate proliferation, survival, differentiation and enucleation of erythroid progenitor cells. We undertook two complimentary approaches to find EPO-dependent pSTAT5 target genes in murine erythroid cells: RNA-seq of newly transcribed (4sU-labelled) RNA, and ChIP-seq for pSTAT5 30 minutes after EPO stimulation. We found 302 pSTAT5-occupied sites: ~15% of these reside in promoters while the rest reside within intronic enhancers or intergenic regions, some >100kb from the nearest TSS...
2017: PloS One
https://www.readbyqxmd.com/read/28732064/mechanisms-of-aggregation-in-an-ant-tended-treehopper-attraction-to-mutualists-is-balanced-by-conspecific-competition
#2
Manuel A Morales, Andrew G Zink
Understanding the spatial structure of populations and communities has been a dominant focus of ecological research, and spatial structure is increasingly seen as critical for understanding population dynamics. Habitat (or host) preference is a proximate mechanism that can generate aggregation or overdispersion, lending insight into the ultimate consequences of observed spatial distributions. Publilia concava is a univoltine phloem-feeding insect that forms mutualistic associations with ants, which consume honeydew and protect treehoppers from predation...
2017: PloS One
https://www.readbyqxmd.com/read/28730857/controversies-in-complex-percutaneous-coronary-intervention-radial-versus-femoral
#3
Ian C Gilchrist, Stephen O Awuor, Rhian E Davies, Anene C Ukaigwe
Evolution in the technology used in the cardiac catheterization laboratory has permitted a migration from the femoral to radial artery access for many interventional procedures while concurrently improving outcomes. As a disruptive technology, transradial access has been associated with several controversies including a dichotomous relationship with femoral access. Areas covered: Several different patient subsets along with perceived technical challenges in interventional cardiology are reviewed with regard to the issue of access site...
July 21, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28730515/selective-induction-of-dna-damage-g2-abrogation-and-mitochondrial-apoptosis-by-leaf-extract-of-traditional-medicinal-plant-wrightia-arborea-in-k562-cells
#4
T Lakshmipriya, T Soumya, P R Jayasree, P R Manish Kumar
Plants have proved to be an important source of anti-cancer drugs. Wrightia arborea, an Indian Ayurvedic medicinal plant, is used traditionally to treat a variety of ailments. This study evaluates the antiproliferative/apoptotic potential of Wrightia arborea leaf extracts, prepared in different organic solvents, on cancer cell lines. MTT assay, light and fluorescence microscopy, flow cytometry, DNA laddering, alkaline comet assay, and western blotting were some of the techniques used for evaluation. Combinations of camptothecin, either with CHK1 inhibitor-PD407824 or with W...
July 20, 2017: Protoplasma
https://www.readbyqxmd.com/read/28719135/multiple-breath-washout-in-paediatric-patients-after-lung-transplantation
#5
Sylvia Nyilas, Julia Carlens, Timothy Price, Florian Singer, Carsten Müller, Gesine Hansen, Gregor Warnecke, Philipp Latzin, Nicolaus Schwerk
Forced expiratory volume in 1 second (FEV1 ) from spirometry, is the most commonly used parameter to detect early allograft dysfunction after lung transplantation (LTx). There are concerns regarding its sensitivity. Nitrogen-multiple breath washout (N2 -MBW) is sensitive at detecting early global (lung clearance index; LCI), and acinar (Sacin ) airway inhomogeneity. We investigated whether N2 -MBW indices indicate small airways pathology after LTx in children with stable spirometry. Thirty-seven children without BOS on median 1...
July 18, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28716718/multivariate-pattern-analysis-of-meg-and-eeg-a-comparison-of-representational-structure-in-time-and-space
#6
Radoslaw Martin Cichy, Dimitrios Pantazis
Multivariate pattern analysis of magnetoencephalography (MEG) and electroencephalography (EEG) data can reveal the rapid neural dynamics underlying cognition. However, MEG and EEG have systematic differences in sampling neural activity. This poses the question to which degree such measurement differences consistently bias the results of multivariate analysis applied to MEG and EEG activation patterns. To investigate, we conducted a concurrent MEG/EEG study while participants viewed images of everyday objects...
July 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28707538/adrenal-cortical-hyperplasia-diagnostic-workup-subtypes-imaging-features-and-mimics
#7
Michelle Agrons, Corey T Jensen, Mouhammed Amir Habra, Christine O Menias, Akram M Shaaban, Nicolaus A Wagner-Bartak, Alicia M Roman-Colon, Khaled M Elsayes
Adrenal cortical hyperplasia manifests radiologically as the nonmalignant growth, or enlargement of the adrenal glands, specifically the cortex, although the cortex cannot be definitively identified by conventional imaging. Controlled by the pituitary gland, the adrenal cortex drives critical processes, such as cortisol, mineralocorticoid, and sex hormone production. Any disruption in the multiple enzymes and hormones involved in these pathways may cause serious or life-threatening symptoms, often associated with anatomical changes of the adrenal glands...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28707532/a-novel-diagnostic-aid-for-intra-abdominal-adhesion-detection-in-cine-mr-imaging-pilot-study-and-initial-diagnostic-impressions
#8
David Randall, Frank Joosten, Richard Ten Broek, Richard Gillott, Karna Dev Bardhan, Chema Strik, Wiesje Prins, Harry van Goor, John Fenner
OBJECTIVES: A non-invasive diagnostic technique for abdominal adhesions is not currently available. Capture of abdominal motion due to respiration in cine-MRI has shown promise, but is difficult to interpret. This article explores the value of a complimentary diagnostic aid to facilitate the non-invasive detection of abdominal adhesions using cine-MRI. METHOD: An image processing technique was developed to quantify the amount of sliding that occurs between the organs of the abdomen and the abdominal wall in sagittal cine-MRI slices...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28705829/regional-variation-in-undulatory-kinematics-of-two-hammerhead-species-the-bonnethead-sphyrna-tiburo-and-the-scalloped-hammerhead-sphyrna-lewini
#9
S L Hoffmann, S M Warren, M E Porter
Hammerhead sharks (Sphyrnidae) are have a large amount of morpholigcal variation within the family, making them the focus of many studies. The size of the laterally expanded head, or cephalofoil, is inversely correlated with pectoral fin area. The inverse relation in cephalofoil and pectoral fin size in this family suggests that they might serve a complimentary role in lift generation. The cephalofoil is also hypothesized to increase olfaction, electroreception, and vision; however, little is known about how morphological variation impacts post-cranial swimming kinematics...
July 13, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28702480/dataset-on-transcriptional-profiles-and-the-developmental-characteristics-of-pdgfr%C3%AE-expressing-lung-fibroblasts
#10
Mehari Endale, Shawn Ahlfeld, Erik Bao, Xiaoting Chen, Jenna Green, Zach Bess, Matthew Weirauch, Yan Xu, Anne Karina Perl
The following data are derived from key stages of acinar lung development and define the developmental role of lung interstitial fibroblasts expressing platelet-derived growth factor alpha (PDGFRα). This dataset is related to the research article entitled "Temporal, spatial, and phenotypical changes of PDGFRα expressing fibroblasts during late lung development" (Endale et al., 2017) [1]. At E16.5 (canalicular), E18.5 (saccular), P7 (early alveolar) and P28 (late alveolar), PDGFRα(GFP) mice, in conjunction with immunohistochemical markers, were utilized to define the spatiotemporal relationship of PDGFRα(+) fibroblasts to endothelial, stromal and epithelial cells in both the proximal and distal acinar lung...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28698507/risk-assessment-of-mycotoxins-in-stored-maize-grains-consumed-by-infants-and-young-children-in-nigeria
#11
Modupeade C Adetunji, Olusegun O Atanda, Chibundu N Ezekiel
Maize is a major complimentary food for infants (0-4years) and young children (5-12years) in Nigeria. In this study, we assessed the risk of exposure of infants and young children (IYC) to some major mycotoxins in stored maize grains from five agro-ecological zones of Nigeria. The probable daily intake approach was employed to determine exposure to five mycotoxins while the margin of exposure (MOE) and population at risk of primary hepatocellular carcinoma approaches were used to characterize the risk of consuming aflatoxin contaminated maize...
July 10, 2017: Children
https://www.readbyqxmd.com/read/28698462/using-health-impact-assessment-as-an-interdisciplinary-teaching-tool
#12
REVIEW
Melissa Chinchilla, Mariana C Arcaya
Health Impact Assessment (HIA) courses are teaching public health and urban planning students how to assess the likely health effects of proposed policies, plans, and projects. We suggest that public health and urban planning have complimentary frameworks for training practitioners to address the living conditions that affect health. Planning perspectives emphasize practical skills for impacting community change, while public health stresses professional purpose and ethics. Frameworks from both disciplines can enhance the HIA learning experience by helping students tackle questions related to community impact, engagement, social justice, and ethics...
July 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28697795/improved-prosthetic-hand-control-with-concurrent-use-of-myoelectric-and-inertial-measurements
#13
Agamemnon Krasoulis, Iris Kyranou, Mustapha Suphi Erden, Kianoush Nazarpour, Sethu Vijayakumar
BACKGROUND: Myoelectric pattern recognition systems can decode movement intention to drive upper-limb prostheses. Despite recent advances in academic research, the commercial adoption of such systems remains low. This limitation is mainly due to the lack of classification robustness and a simultaneous requirement for a large number of electromyogram (EMG) electrodes. We propose to address these two issues by using a multi-modal approach which combines surface electromyography (sEMG) with inertial measurements (IMs) and an appropriate training data collection paradigm...
July 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28696623/-doctor-%C3%A2-i-hurt-everywhere-%C3%A2
#14
Carine Eichenberger, Jean Dudler, Régis Marion-Veyron, Ariane Gonthier, Jacques Cornuz, Bernard Favrat
Faced with diffuse pain, the doctor must evoke a wide range of pathologies. It is necessary to think about rare illnesses such as myopathy or vasculitis, but also more common illnesses such as fibromyalgia. Contrary to popular belief, it is difficult to give a diagnosis of fibromyalgia, on average 2 years after the onset of symptoms. This can be explained by heterogeneous complaints and the doctor delaying the diagnosis with unnecessary complimentary examinations.Patient education and physical activity are the most important steps of treatment...
November 2, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28695826/an-insect-anti-antiaphrodisiac
#15
Colin S Brent, John A Byers, Anat Levi-Zada
Passive mechanisms of mate guarding are used by males to promote sperm precedence with little cost, but these tactics can be disadvantageous for their mates and other males. Mated females of the plant bug Lygus hesperus are rendered temporarily unattractive by seminal fluids containing myristyl acetate and geranylgeranyl acetate. These antiaphrodisiac pheromones are gradually released from the female's gonopore, declining until they no longer suppress male courtship. Because starting quantities of these compounds can vary widely, the repellant signal becomes less reliable over time...
July 11, 2017: ELife
https://www.readbyqxmd.com/read/28694579/surgical-repair-of-congenital-abdominal-aortic-aneurysm-in-a-1-year-old-child-with-literature-review
#16
Ashwani Bansal, Aparajita Mitra, Akshay Kumar Bisoi, Sandeep Agarwala
Reported here is a case of 1-year-old male child who presented with huge abdominal mass, which on radiological investigation was diagnosed as retroperitoneal pseudoaneurysm of the aorta. On exploration, it was found to be a true aneurysm of infrarenal abdominal aorta with inflow agenesis. Aneurysm was excised, and aorta was reconstructed with 10 mm Dacron graft. Postoperative computed tomography angiography showed patent graft with good distal runoff. Literature review revealed that only 26 cases of congenital abdominal aortic aneurysm had been reported so far...
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28693314/plasmonic-vertically-coupled-complementary-antennas-for-dual-mode-infrared-molecule-sensing
#17
Xiahui Chen, Chu Wang, Yu Yao, Chao Wang
Here we report an infrared plasmonic nanosensor for label-free, sensitive, specific, and quantitative identification of nanometer-sized molecules. The device design is based on vertically coupled complementary antennas with densely patterned hot-spots. The elevated metallic nanobars and complimentary nanoslits in the substrate strongly couple at vertical nano-gaps between them, resulting in dual-mode sensing dependent on the light polarization parallel or perpendicular to the nanobars. We demonstrate experimentally that a monolayer of octadecanethiol (ODT) molecules (thickness 2...
July 10, 2017: ACS Nano
https://www.readbyqxmd.com/read/28692450/advances-in-midface-reconstruction-beyond-the-reconstructive-ladder
#18
Antoine Eskander, Stephen Y Kang, Theodoros N Teknos, Matthew O Old
PURPOSE OF REVIEW: This article reviews the anatomy and function of the midface, defect classifications and the breadth of common and novel reconstructive techniques including medical modeling, dental splints, and dental rehabilitation. RECENT FINDINGS: Historically many classification systems for midface and maxillary defects exist but most defects are unique and an individualized approach is required. There has been an increased interest in using regional pedicled flaps with bone for reconstruction...
July 7, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28690499/reduced-circulating-levels-of-mir-433-and-mir-133b-are-potential-biomarkers-for-parkinson-s-disease
#19
Xiong Zhang, Rui Yang, Bei-Lei Hu, Pengcheng Lu, Li-Li Zhou, Zhi-Yong He, Hong-Mei Wu, Jian-Hong Zhu
Aberrant expression of microRNA (miRNA) in tissues may lead to altered level in circulation. Considerable evidence has suggested that miRNA deregulation is involved in the pathogenesis of Parkinson's disease (PD). In this study, we screened a set of PD-associated miRNAs and aimed to identify differentially expressed miRNAs in plasma of PD patients and to evaluate their potentiality to serve as PD biomarkers. A total of 95 subjects consisting of 46 sporadic PD cases and 49 controls were recruited. Plasma levels of six miRNAs including miR-433, miR-133b, miR-34b, miR-34c, miR-153, and miR-7 were evaluated using reverse transcribed quantitative PCR, among which we found that miR-34c and miR-7 were below detection limit under our condition...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28681208/surgical-considerations-in-the-optimal-management-of-patients-with-malignant-brain-tumors
#20
REVIEW
Jaclyn J Renfrow, Roy E Strowd, Adrian W Laxton, Stephen B Tatter, Carol P Geer, Glenn J Lesser
Advances in technology are revolutionizing medicine and the limits of what we can offer to our patients. In neurosurgery, technology continues to reduce morbidity, increase surgical accuracy, facilitate tissue acquisition, and promote novel techniques for prolonging survival in patients with neuro-oncologic disease. Surgery has been the backbone of glioma diagnosis and treatment by providing adequate, high quality material for precise histologic diagnosis, and genomic characterization in the setting of significant intratumoral heterogeneity, thus allowing personalized treatment selection in the clinic...
August 2017: Current Treatment Options in Oncology
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