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https://www.readbyqxmd.com/read/28431395/correlation-of-genomic-alterations-assessed-by-next-generation-sequencing-ngs-of-tumor-tissue-dna-and-circulating-tumor-dna-ctdna-in-metastatic-renal-cell-carcinoma-mrcc-potential-clinical-implications
#1
Andrew W Hahn, David M Gill, Benjamin Maughan, Archana Agarwal, Lubina Arjyal, Sumati Gupta, Jessica Streeter, Erin Bailey, Sumanta K Pal, Neeraj Agarwal
INTRODUCTION: Tumor tissue and circulating tumor DNA (ctDNA) next-generation sequencing (NGS) testing are frequently performed to detect genomic alterations (GAs) to help guide treatment in metastatic renal cell carcinoma (mRCC), especially after progression on standard systemic therapy. Our objective was to assess if GAs detected by ctDNA NGS are different from those detected by tumor tissue NGS, specifically in patients with mRCC, and if these platforms are interchangeable or complimentary...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430416/a-complimentary-benzophenone-cross-linking-mass-spectrometry-photochemistry
#2
Adam Belsom, Gemma Mudd, Sven H Giese, Manfred Auer, Juri Rappsilber
Use of a heterobifunctional photoactivatable cross-linker, sulfo-SDA (diazirine), has yielded high-density data that facilitated structure modelling of individual proteins. We expand the photoactivatable chemistry toolbox here with a second reagent, sulfo-SBP (benzophenone). This further increases the density of photo-cross-linking to a factor of 20x over conventional cross-linking. Importantly, the two different photoactivatable groups display orthogonal directionality, enabling access to different protein regions, unreachable with a single cross-linker...
April 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28428332/education-in-nephrology-fellowship-a-survey-based-needs-assessment
#3
Robert W Rope, Kurtis A Pivert, Mark G Parker, Stephen M Sozio, Sylvia Bereknyei Merell
Educational needs assessments for nephrology fellowship training are limited. This study assessed fellows' perceptions of current educational needs and interest in novel modalities that may improve their educational experience and quantified educational resources used by programs and fellows. We distributed a seven-question electronic survey to all United States-based fellows receiving complimentary American Society of Nephrology (ASN) membership at the end of the 2015-2016 academic year in conjunction with the ASN Nephrology Fellows Survey...
April 20, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28424360/intermittent-hypoxia-in-obstructive-sleep-apnoea-mediates-insulin-resistance-through-adipose-tissue-inflammation
#4
Aoife M Murphy, Amandine Thomas, Sophie J Crinion, Brian D Kent, Murtaza M Tambuwala, Aurelie Fabre, Jean-Louis Pepin, Helen M Roche, Claire Arnaud, Silke Ryan
Obstructive sleep apnoea (OSA) is increasingly associated with insulin resistance. The underlying pathophysiology remains unclear but intermittent hypoxia (IH)-mediated inflammation and subsequent dysfunction of the adipose tissue has been hypothesised to play a key role.We tested this hypothesis employing a comprehensive translational approach using a murine IH model of lean and diet-induced obese mice, an innovative IH system for cell cultures and a tightly controlled patient cohort.IH led to the development of insulin resistance in mice, corrected for the degree of obesity, and reduced insulin-mediated glucose uptake in 3T3-L1 adipocytes, associated with inhibition of the insulin-signalling pathway and downregulation of insulin-receptor substrate-1 mRNA...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28417096/regulation-of-herbal-medicine-use-based-on-speculation-a-case-from-sri-lanka
#5
Wathsala Wijesinghe, Senaka Pilapitiya, Priyani Hettiarchchi, Buddhika Wijerathne, Sisira Siribaddana
Chronic Kidney Disease of Unknown aetiology is a significant public health problem in Sri Lanka. The final report by the WHO mission recommended regulation of herbal medicines containing aristolochic acid, which is an established nephrotoxin. The use of Complimentary and Alternative Medicine (CAM) has a history of more than 2500 years in Sri Lanka. Aristolochia species are rarely used in Ayurveda and traditional medicine in Sri Lanka. Before regulating the analysis of herbal preparations using Aristolochia, collecting data from CAM practitioners regarding the use of Aristolochia is necessary...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28409852/tandem-mass-spectrometric-analysis-of-novel-peptide-modified-gemini-surfactants-used-as-gene-delivery-vectors
#6
Mays Al-Dulaymi, Anas El-Aneed
Diquaternary ammonium gemini Surfactants have emerged as effective gene delivery vectors. A novel series of eleven peptide-modified compounds was synthesized, showing promising results in delivering genetic materials. The purpose of this work is to elucidate the tandem mass spectrometric (MS/MS) dissociation behaviour of these novel molecules establishing a generalized MS/MS fingerprint. Exact mass measurements were achieved using a hybrid quadrupole orthogonal time-of-flight mass spectrometer (QqToF-MS) and a multi-stage tandem mass spectrometric analysis was conducted using a triple quadrupole-linear ion trap mass spectrometer (QqQLIT-MS)...
April 14, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28407412/adsorption-and-desorption-of-single-stranded-dna-from-single-walled-carbon-nanotubes
#7
Cameron James Shearer, LePing Yu, Renzo Fenati, Alex Sibley, Jamie Scott Quinton, Christopher Thomas Gibson, Amanda Vera Ellis, Gunther Andersson, Joseph George Shapter
The chemical affinity of single stranded DNA (ssDNA) to adsorb to the surface of single walled carbon nanotubes (SWCNTs) is used for SWCNT purification, separation and in bio-devices. Despite the popularity of research on SWCNT-ssDNA conjugates, very little work has been dedicated to study the removal of adsorbed ssDNA on SWCNTs. This paper reports a comprehensive study of biological, physical and chemical treatments for the removal of ssDNA from SWCNT-ssDNA suspensions. These include enzymatic cleavage, heat treatment under vacuum up to 400 oC, chemical treatments with high or low pH, oxidising conditions, and high ionic strength solvents...
April 13, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28406932/a-comparison-of-stimulus-types-in-online-classification-of-the-p300-speller-using-language-models
#8
William Speier, Aniket Deshpande, Lucy Cui, Nand Chandravadia, Dustin Roberts, Nader Pouratian
The P300 Speller is a common brain-computer interface communication system. There are many parallel lines of research underway to overcome the system's low signal to noise ratio and thereby improve performance, including using famous face stimuli and integrating language information into the classifier. While both have been shown separately to provide significant improvements, the two methods have not yet been implemented together to demonstrate that the improvements are complimentary. The goal of this study is therefore twofold...
2017: PloS One
https://www.readbyqxmd.com/read/28405576/evaluation-of-anti-diabetic-activity-of-ahpl-aytab-0513-tablet-in-streptozotocin-induced-diabetes-in-rats
#9
Sanjay U Nipanikar, Soham S Chitlange, Dheeraj Nagore
BACKGROUND: Diabetes is a chronic, progressive disease associated with several complications leading to significant mortality and morbidity. Limitations and drawbacks of the conventional treatment generate need for safer, effective complimentary therapies to prevent complications, and maintain normoglycemic status. AIM AND OBJECTIVES: The aim of this study is to to evaluate antidiabetic activity of AHPL/AYTAB/0513 tablet alone, oral hypoglycemic agents (OHA[s]), and combination of AHPL/AYTAB/0513 tablet and OHA(s) in streptozotocin-induced diabetes in rats...
January 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28394937/the-brazilian-freshwater-wetscape-changes-in-tree-community-diversity-and-composition-on-climatic-and-geographic-gradients
#10
Florian Wittmann, Márcia C M Marques, Geraldo Damasceno Júnior, Jean Carlos Budke, Maria T F Piedade, Astrid de Oliveira Wittmann, Juan Carlos Montero, Rafael L de Assis, Natália Targhetta, Pia Parolin, Wolfgang J Junk, J Ethan Householder
Wetlands harbor an important compliment of regional plant diversity, but in many regions data on wetland diversity and composition is still lacking, thus hindering our understanding of the processes that control it. While patterns of broad-scale terrestrial diversity and composition typically correlate with contemporary climate it is not clear to what extent patterns in wetlands are complimentary, or conflicting. To elucidate this, we consolidate data from wetland forest inventories in Brazil and examine patterns of diversity and composition along temperature and rainfall gradients spanning five biomes...
2017: PloS One
https://www.readbyqxmd.com/read/28392853/pulsatility-index-of-popliteal-artery-in-patients-with-isolated-calf-vein-thrombosis-a-novel-technique-for-detecting-thrombosis
#11
Abdussamet Batur, Vural Polat, Mesut Ozgokce, Muhammed Alpaslan, Alpaslan Yavuz, Harun Arslan, Aydin Bora, Mehmet Emin Sakarya
BACKGROUND: To investigate the usefulness of popliteal artery spectral doppler findings as a complimentary approach to isolated calf vein thrombosis (DVT). MATERIAL/METHODS: We included consecutive patients presenting with symptomatic and sonographically proven acute isolated calf DVT. Patients with thrombosis of any other vein were excluded. We classified calf vein into into four main types. We investigated how many of these four vessels had DVT and compared them with respect to the pulsatility index (PI) value of the popliteal artery...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28392492/pulse-sequences-and-parallel-imaging-for-high-spatiotemporal-resolution-mri-at-ultra-high-field
#12
Benedikt A Poser, Kawin Setsompop
The SNR and CNR benefits of ultra-high field (UHF) have helped push the envelope of achievable spatial resolution in MRI. For applications based on susceptibility contrast where there is a large CNR gain, high quality sub-millimeter resolution imaging is now being routinely performed, particularly in fMRI and phase imaging/QSM. This has enabled the study of structure and function of very fine-scale structures in the brain. UHF has also helped push the spatial resolution of many other MRI applications as will be outlined in this review...
April 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28391862/chemical-and-canine-analysis-as-complimentary-techniques-for-the-identification-of-active-odors-of-the-invasive-fungus-raffaelea-lauricola
#13
Alison G Simon, DeEtta K Mills, Kenneth G Furton
Raffaelea lauricola, a fungus causing a vascular wilt (laurel wilt) in Lauraceae trees, was introduced into the United States in the early 2000s. It has devastated forests in the Southeast and has now moved into the commercial avocado groves in southern Florida. Trained detection canines are currently one of the few successful methods for early detection of pre-symptomatic diseased trees. In order to achieve the universal and frequent training required to have successful detection canines, it is desirable to create accessible, safe, and long-lasting training aids...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28384184/assessing-biosynthetic-potential-of-agricultural-groundwater-through-metagenomic-sequencing-a-diverse-anammox-community-dominates-nitrate-rich-groundwater
#14
William B Ludington, Thaddeus D Seher, Olin Applegate, Xunde Li, Joseph I Kliegman, Charles Langelier, Edward R Atwill, Thomas Harter, Joseph L DeRisi
BACKGROUND: Climate change produces extremes in both temperature and precipitation causing increased drought severity and increased reliance on groundwater resources. Agricultural practices, which rely on groundwater, are sensitive to but also sources of contaminants, including nitrate. How agricultural contamination drives groundwater geochemistry through microbial metabolism is poorly understood. METHODS: On an active cow dairy in the Central Valley of California, we sampled groundwater from three wells at depths of 4...
2017: PloS One
https://www.readbyqxmd.com/read/28379974/non-invasive-phenotyping-and-drug-testing-in-single-cardiomyocytes-or-beta-cells-by-calcium-imaging-and-optogenetics
#15
Yu-Fen Chang, Connor N Broyles, Frances A Brook, Mark J Davies, Cameron W Turtle, Takeharu Nagai, Matthew J Daniels
Identification of drug induced electrical instability of the heart curtails development, and introduction, of potentially proarrhythmic drugs. This problem usually requires complimentary contact based approaches such as patch-clamp electrophysiology combined with field stimulation electrodes to observe and control the cell. This produces data with high signal to noise but requires direct physical contact generally preventing high-throughput, or prolonged, phenotyping of single cells or tissues. Combining genetically encoded optogenetic control and spectrally compatible calcium indicator tools into a single adenoviral vector allows the analogous capability for cell control with simultaneous cellular phenotyping without the need for contact...
2017: PloS One
https://www.readbyqxmd.com/read/28378719/weak-hydrogen-bonding-and-fluorous-interactions-in-the-chloride-and-bromide-salts-of-4-2-2-3-3-tetrafluoropropoxy-methyl-pyridinium
#16
Norman Lu, Rong Jyun Wei, Kwan Yu Lin, Mani Alagesan, Yuh Sheng Wen, Ling Kang Liu
Neutralization of 4-[(2,2,3,3-tetrafluoropropoxy)methyl]pyridine with hydrohalo acids HX (X = Cl and Br) yielded the pyridinium salts 4-[(2,2,3,3-tetrafluoropropoxy)methyl]pyridinium chloride, C9H10F4NO(+)·Cl(-), (1), and 4-[(2,2,3,3-tetrafluoropropoxy)methyl]pyridinium bromide, C9H10F4NO(+)·Br(-), (2), both carrying a fluorous side chain at the para position of the pyridinium ring. Single-crystal X-ray diffraction techniques revealed that (1) and (2) are isomorphous. The halide anions accept four hydrogen bonds from N-H, ortho-C-H and CF2-H groups...
April 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28374681/a-reliable-and-controllable-graphene-doping-method-compatible-with-current-cmos-technology-and-the-demonstration-of-its-device-applications
#17
Seonyeong Kim, Somyeong Shin, Taekwang Kim, Hyewon Du, Minho Song, Ki Soo Kim, Seungmin Cho, Sang Wook Lee, Sunae Seo
The modulation of charge carrier concentration allows us to tune the Fermi level (E F) of graphene thanks to the low electronic density of states near the E F. The introduced metal oxide thin films as well as the modified transfer process can elaborately maneuver the amounts of charge carrier concentration in graphene. The self-encapsulation provides a solution to overcome the stability issues of metal oxide hole dopants. We have manipulated systematic graphene p-n junction structures for electronic or photonic application-compatible doping methods with current semiconducting process technology...
April 28, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28367025/role-of-p16-ink4a-and-ki-67-as-specific-biomarkers-for-cervical-intraepithelial-neoplasia-an-institutional-study
#18
Ankitha Hebbar, Venkataramappa Srinivasa Murthy
BACKGROUND: P16/INK4a and Ki-67 have emerged as important biomarkers for the detection of high-risk human papilloma virus (HR-HPV) associated dysplastic changes in the cervical biopsy samples. The increasing inter- and intra-observer variability in the diagnosis of dysplastic lesions and immature squamous metaplasia on histopathology has led to the advent of these biomarkers. This study was taken up with an aim to study their role in increasing the diagnostic accuracy in equivocal cases on histopathology...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28361831/evolving-management-of-insulinoma-experience-at-a-tertiary-care-centre
#19
Viveka P Jyotsna, Sujoy Pal, D Kandasamy, S Gamanagatti, P K Garg, N Raizada, Peush Sahni, C S Bal, N Tandon, A C Ammini
BACKGROUND & OBJECTIVES: Since our previous study in 2006, several new modalities for localization of cause of endogenous hyperinsulinemic hypoglycaemia such as multiphasic computed tomography (CT), multiphasic magnetic resonance imaging (MRI), endoscopic ultrasound (EUS), intraoperative ultrasound, and intra-arterial calcium infusion with arterial stimulation venous sampling (ASVS) have become available. Therefore, to evaluate the relative usefulness of various imaging modalities to guide future management in terms of diagnosis and patient care, we analyzed presentation and management of patients of endogenous hyperinsulinemic hypoglycaemia...
November 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28358268/exploring-the-potential-for-secondary-uses-of-dementia-care-mapping-dcm-data-for-improving-the-quality-of-dementia-care
#20
Shehla Khalid, Claire Surr, Daniel Neagu, Neil Small
The reuse of existing datasets to identify mechanisms for improving healthcare quality has been widely encouraged. There has been limited application within dementia care. Dementia Care Mapping is an observational tool in widespread use, predominantly to assess and improve quality of care in single organisations. Dementia Care Mapping data have the potential to be used for secondary purposes to improve quality of care. However, its suitability for such use requires careful evaluation. This study conducted in-depth interviews with 29 Dementia Care Mapping users to identify issues, concerns and challenges regarding the secondary use of Dementia Care Mapping data...
January 1, 2017: Dementia
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