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https://www.readbyqxmd.com/read/29166297/assessing-patients-perceptions-of-safety-culture-in-the-hospital-setting-development-and-initial-evaluation-of-the-patients-perceptions-of-safety-culture-scale
#1
Clara Monaca, Beate Bestmann, Martina Kattein, Daria Langner, Hardy Müller, Tanja Manser
OBJECTIVES: Both, patient satisfaction and hospital safety culture have been recognized as key characteristics of healthcare quality and patient safety. Thus, both characteristics are measured widely to support quality and safety improvement efforts. However, because safety culture surveys focus exclusively on the perspective of hospital staff, the complimentary information to be gained from patients' perceptions of safety culture has received little research attention so far. We aimed to develop a measure explicitly focusing on patients' perceptions of safety culture in the hospital setting and perform an initial evaluation of its measurement properties...
November 21, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29160140/the-effects-of-weighted-skates-on-ice-skating-kinematics-kinetics-and-muscular-activity
#2
Matthew P Mavor, Dean C Hay, Ryan B Graham
Sport-specific resistance training, through limb loading, can be a complimentary training method to traditional resistance training by loading the working muscles during all phases of a specific movement. The purpose of this study was to examine the acute effects of skating with an additional load on the skate, using a skate weight prototype, on kinematics, kinetics, and muscle activation during the acceleration phase while skating on a synthetic ice surface. 10 male hockey skaters accelerated from rest (standing erect with knees slightly bent) under four non-randomized load conditions: baseline 1 (no weight), light (0...
November 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29153491/measures-of-human-immunodeficiency-virus-hiv-community-viral-load-and-hiv-incidence-among-people-who-inject-drugs
#3
Cristie Glasheen, Eric O Johnson, Jennifer Lorvick, Alex H Kral
PURPOSE: To evaluate the measures of community human immunodeficiency virus (HIV) viral load (VL) and the association with HIV incidence among people who inject drugs (PWID). METHODS: Data were from 1986 to 1999 Urban Health Study conducted among PWID in the San Francisco Bay Area. Extant measures of community VL use mean VL among HIV + study participants, not accounting for the proportion of HIV- individuals. We compared the strength of the associations between HIV incidence and the traditionally measured mean community VL and a new prevalence-adjusted community VL, calculated by dividing the sum of VL among HIV + participants by the total participants irrespective of HIV status...
November 3, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29151824/a-real-time-metabolomic-profiling-approach-to-detecting-fish-fraud-using-rapid-evaporative-ionisation-mass-spectrometry
#4
Connor Black, Olivier P Chevallier, Simon A Haughey, Julia Balog, Sara Stead, Steven D Pringle, Maria V Riina, Francesca Martucci, Pier L Acutis, Mike Morris, Dimitrios S Nikolopoulos, Zoltan Takats, Christopher T Elliott
Introduction: Fish fraud detection is mainly carried out using a genomic profiling approach requiring long and complex sample preparations and assay running times. Rapid evaporative ionisation mass spectrometry (REIMS) can circumvent these issues without sacrificing a loss in the quality of results. Objectives: To demonstrate that REIMS can be used as a fast profiling technique capable of achieving accurate species identification without the need for any sample preparation...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29145713/positron-emission-tomography-as-an-imaging-biomarker-in-a-prospective-longitudinal-cohort-of-patients-with-large-vessel-vasculitis
#5
Peter C Grayson, Sara Alehashemi, Armin A Bagheri, Ali Cahid Civelek, Thomas R Cupps, Mariana J Kaplan, Ashkan A Malayeri, Peter A Merkel, Elaine Novakovich, David A Bluemke, Mark A Ahlman
OBJECTIVES: To assess the clinical value of (18) F-flurodeoxyglucose (FDG) positron emission tomography (PET) in a prospective cohort of patients with large-vessel vasculitis (LVV) and disease comparators. METHODS: Patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA) were studied, along with a comparator group consisting of patients with hyperlipidemia, diseases that mimic LVV, and healthy controls. Participants underwent clinical evaluation and FDG-PET imaging, and patients with LVV underwent serial imaging at six-month intervals...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29141791/comparing-the-efficacy-of-disease-modifying-therapies-in-multiple-sclerosis
#6
REVIEW
Dimos D Mitsikostas, Douglas S Goodin
Establishing the relative efficacy and safety of the different disease modifying therapies (DMTs) in multiple sclerosis (MS) is critical to the choice of agent that clinicians recommend for individual MS patients. The best evidence for the relative efficacy of the different DMTs comes from head-to-head randomized clinical trials (RCTs). Understanding that outcome-measures with the best established validity are the relapse rate and the actual (not the "confirmed") change in the extended disability status scale (EDSS), we conclude from these head-to-head RCTs that interferon-beta (IFNβ) given subcutaneously multiple times per week (either IFNβ-1b or IFNβ-1a) and glatiramer acetate (GA) are about equivalent in terms of efficacy and that both of these agents, as well as many of the other DMTs, are superior to weekly intramuscular IFNβ-1a...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29136868/a-pcr-free-colorimetric-strategy-for-visualized-assay-of-telomerase-activity
#7
Tao Yu, Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
A simple yet powerful polymerase chain reaction (PCR)-free strategy for visualized assay of human telomerase activity was reported in this work. Gold nanoparticles (AuNPs) based colorimetric strategy was applied with well-designed enzyme-aided cyclic amplification. Briefly, the detection relies on the elongated primers of telomerase substrate (TS) induced by telomerase, which open the hairpin DNA and hybridize with linker DNA, the trigger of AuNPs aggregation. Nicking endonuclease was added in the sensing system, which cleaved linker DNA after hybridization and released complimentary strand for cyclic hybridization with linker DNA, resulted in high sensitivity for the detection of telomerase...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29135230/multidimensional-spectral-fingerprints-of-a-new-family-of-coherent-analytical-spectroscopies
#8
Nathan Andrew Neff-Mallon, John C Wright
Triply Resonant Sum Frequency (TRSF) and Doubly Vibrationally Enhanced (DOVE) spectroscopies are examples of a recently developed family of Coherent Multidimensional Spectroscopies (CMDS) that are analogous to current analytical spectroscopies. They are based on creating quantum mechanical superposition states that are fully coherent and lack intermediate quantum state populations that cause quenching or other relaxation effects. They provide multidimensional spectral fingerprints consisting of mixtures of vibrational and electronic states...
November 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29133888/neuronal-hyperactivity-due-to-loss-of-inhibitory-tone-in-apoe4-mice-lacking-alzheimer-s-disease-like-pathology
#9
Tal Nuriel, Sergio L Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S Gross, S Abid Hussaini, Herman Moreno, Scott A Small, Karen E Duff
The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer's disease (AD). However, the reason APOE4 is associated with increased AD risk remains a source of debate. Neuronal hyperactivity is an early phenotype in both AD mouse models and in human AD, which may play a direct role in the pathogenesis of the disease. Here, we have identified an APOE4-associated hyperactivity phenotype in the brains of aged APOE mice using four complimentary techniques-fMRI, in vitro electrophysiology, in vivo electrophysiology, and metabolomics-with the most prominent hyperactivity occurring in the entorhinal cortex...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29125280/a-haptacyclic-carbazole-based-ladder-type-non-fullerene-acceptor-with-side-chain-optimization-for-efficient-organic-photovoltaics
#10
Yu-Tang Hsiao, Chia-Hua Li, Shao-Ling Chang, Soowon Heo, Keisuke Tajima, Yen-Ju Cheng, Chain-Shu Hsu
In this research, a haptacyclic carbazole-based dithienocyclopentacarbazole (DTCC) ladder-type structure was formylated to couple with two 1,1-dicyanomethylene-3-indanone (IC) moieties, forming a new non-fullerene acceptor DTCCIC-C17 using a bulky branched 1-octylnonayl side chain at the nitrogen of the embedded carbazole and four 4-octylphenyl groups at the sp3-carbon bridges. The rigid and coplanar main-chain backbone of DTCC core provides a broad light-absorbing window and a higher-lying LUMO energy level, while the bulky flanked side chains to reduce intermolecular interactions make DTCCIC-C17 amorphous with excellent solution processability...
November 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29123150/lung-clearance-index-and-quantitative-computed-tomography-of-post-infectious-bronchiolitis-obliterans-in-infants
#11
Yoon Hee Kim, Hyun Joo Shin, In Suk Sol, Soo Yeon Kim, Jong Deok Kim, Haesung Yoon, Kyung Won Kim, Myung-Joon Kim, Mi-Jung Lee, Myung Hyun Sohn
Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infants (mean age, 10.9 ± 6.3 months) diagnosed with post-infectious BO between 2009 and 2016. All subjects underwent multiple breath washout tests. For quantitative analysis of chest CT, the mean lung area attenuation value was used as an individual cutoff to determine the air-trapping lung volume...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119453/neighborhood-structural-differences-and-women-s-mental-health-an-empirical-study-in-accra-ghana
#12
Elijah Bisung, Joseph Kangmennaang, Isaac Luginaah
PURPOSE: This study explores the relationships between neighborhood structural differences such as socioeconomic status (SES), income inequality, and ethnic diversity on women's mental health in Accra, Ghana. METHODS: The study used secondary data from the 2009 Women Health Survey Accra II, linked with the 2010 sub-metro level census figures on income inequality. The analytical sample consists of 2814 women nested within 195 enumeration areas (clusters) in the Accra Metropolitan Area (AMA)...
November 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29107282/the-autonomic-nervous-system-and-cardiac-glp-1-receptors-control-heart-rate-in-mice
#13
Laurie L Baggio, John R Ussher, Brent A McLean, Xiemin Cao, M Golam Kabir, Erin E Mulvihill, Alexandra S Mighiu, Hangjun Zhang, Andreas Ludwig, Randy J Seeley, Scott P Heximer, Daniel J Drucker
OBJECTIVES: Glucagon-like peptide-1 (GLP-1) is secreted from enteroendocrine cells and exerts a broad number of metabolic actions through activation of a single GLP-1 receptor (GLP-1R). The cardiovascular actions of GLP-1 have garnered increasing attention as GLP-1R agonists are used to treat human subjects with diabetes and obesity that may be at increased risk for development of heart disease. Here we studied mechanisms linking GLP-1R activation to control of heart rate (HR) in mice...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29104182/lipid-peroxidation-in-cardiac-surgery-towards-consensus-on-biomonitoring-diagnostic-tools-and-therapeutic-implementation
#14
Rosalba Romano, Simona M Cristescu, Terence H Risby, Nandor Marczin
This review focuses on oxidative stress and more specifically lipid peroxidation in cardiac surgery, one of the fundamental theories of perioperative complications. We present the molecular pathways leading to lipid peroxidation and integrate analytical methods that allow detection of lipid peroxidation markers in the fluid phase with those focusing on volatile compounds in exhaled breath. In order to explore the accumulated data in the literature, we present a systematic review of quantitative analysis of malondialdehyde (MDA), a widely used lipid peroxidation product at various stages of cardiac surgery...
November 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29095951/perceptual-judgments-made-better-by-indirect-interactions-evidence-from-a-joint-localization-task
#15
Pavel Valeryevich Voinov, Natalie Sebanz, Günther Knoblich
Others' perceptual judgments tend to have strong effects on our own, and can improve perceptual judgments when task partners engage in communication. The present study investigated whether individuals benefit from others' perceptual judgments in indirect interactions, where outcomes of individual decisions can be observed in a shared environment. Participants located a target in a 2D projection of a 3D container either from two complementary viewpoints (Experiment 1), or from a single viewpoint (Experiment 2)...
2017: PloS One
https://www.readbyqxmd.com/read/29082339/dnajc18-a-novel-type-iii-dnaj-family-protein-is-expressed-specifically-in-rat-male-germ-cells
#16
Cynthia Gomes, Jaemog Soh
Mammalian spermatogenesis occurs in a precise and coordinated manner in the seminiferous tubules. One of the attempts to understand the detailed biological process during mammalian spermatogenesis at the molecular level has been to identify the testis specific genes followed by study of the testicular expression pattern of the genes. From the subtracted cDNA library of rat testis prepared using representational difference analysis (RDA) method, a complimentary DNA clone encoding type III member of a DnaJ family protein, DnaJC18, was cloned (GenBank Accession No...
September 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29079816/flexible-and-tunable-3d-gold-nanocups-platform-as-plasmonic-biosensor-for-specific-dual-lspr-sers-immuno-detection
#17
M Focsan, A M Craciun, M Potara, C Leordean, A Vulpoi, D Maniu, S Astilean
Early medical diagnostic in nanomedicine requires the implementation of innovative nanosensors with highly sensitive, selective, and reliable biomarker detection abilities. In this paper, a dual Localized Surface Plasmon Resonance - Surface Enhanced Raman Scattering (LSPR- SERS) immunosensor based on a flexible three-dimensional (3D) gold (Au) nanocups platform has been implemented for the first time to operate as a relevant "proof-of-concept" for the specific detection of antigen-antibody binding events, using the human IgG - anti-human IgG recognition interaction as a model...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29070748/complimentary-use-of-needle-electromyography-and-ultrasonography-of-tongue-is-effective-for-early-detection-of-abnormality-in-20-patients-with-amyotrophic-lateral-sclerosis
#18
Miwako Kido, Natsumi Fujisaki, Tetsuya Miyagi, Satoshi Ishihara, Ryo Nakachi, Shugo Suwazono
A group of 20 consecutive patients with amyotrophic lateral sclerosis (ALS) were evaluated using electromyography (EMG) and ultrasonography (US) of the tongue. Their records were reviewed retrospectively for the rates at which abnormalities were detected by these two modalities as well as their clinical features. Visual inspection detected abnormalities in 9 of 20 patients, EMG in 12, and US in 6. However, EMG detected active denervation earlier than did US in 7 of the 12 EMG-diagnosed patients, and US detected fasciculation earlier than did EMG in 1 of the 6 US-diagnosed patients...
October 26, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29060795/real-time-estimation-of-eye-gaze-by-in-ear-electrodes
#19
A Favre-Felix, C Graversen, T Dau, T Lunner
Cognitive control of a hearing aid is the topic for several ongoing studies. The relevance of these studies should be seen in the light of inadequate steering of current hearing aids. While most studies are concerned with auditory attention tracking from the electroencephalogram (EEG), a complimentary approach may be to use visual attention tracking to steer the devices. Visual attention may be characterized by gaze direction, which can be obtained by electrooculography (EOG). EOG may be recorded from electrodes placed in the ear canal, termed EarEOG...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056069/quantifying-the-relationship-between-capability-and-health-in-older-people-can-t-map-won-t-map
#20
Matthew Franklin, Katherine Payne, Rachel A Elliott
BACKGROUND: Intuitively, health and capability are distinct but linked concepts. This study aimed to quantify the link between a measure of health status (EQ-5D-3L) and capability (ICECAP-O) using regression-based methods. METHODS: EQ-5D-3L and ICECAP-O data were collected from a sample of older people ( n = 584), aged over 65 years, requiring a hospital visit and/or care home resident, and recruited to one of 3 studies forming the Medical Crisis in Older People (MCOP) program in England...
October 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
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