keyword
MENU ▼
Read by QxMD icon Read
search

Skin cancer,melanoma

keyword
https://www.readbyqxmd.com/read/29772645/anticancer-activity-of-euplotin-c-isolated-from-the-marine-ciliate-euplotes-crassus-against-human-melanoma-cells
#1
Sara Carpi, Beatrice Polini, Giulio Poli, Gabriela Alcantara Barata, Stefano Fogli, Antonella Romanini, Tiziano Tuccinardi, Graziano Guella, Francesco Paolo Frontini, Paola Nieri, Graziano Di Giuseppe
Cutaneous melanoma is the most serious type of skin cancer, so new cytotoxic weapons against novel targets in melanoma are of great interest. Euplotin C (EC), a cytotoxic secondary metabolite of the marine ciliate Euplotes crassus , was evaluated in the present study on human cutaneous melanoma cells to explore its anti-melanoma activity and to gain more insight into its mechanism of action. EC exerted a marked cytotoxic effect against three different human melanoma cell lines (A375, 501Mel and MeWo) with a potency about 30-fold higher than that observed in non-cancer cells (HDFa cells)...
May 16, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29771903/incidence-demographics-and-surgical-outcomes-of-cutaneous-squamous-cell-carcinoma-diagnosed-in-northland-new-zealand
#2
Brodie M Elliott, Benjamin R Douglass, Daniel McConnell, Blair Johnson, Christopher Harmston
AIM: Non-melanoma skin cancer (NMSC) is the most commonly diagnosed and most costly cancer in Australasia. Cutaneous squamous cell carcinoma (cSCC) accounts for approximately 25% of NMSC. Despite this, reporting of cSCC is not mandatory in Australasia. This creates difficulties in planning, resourcing and improving outcomes in cSCC. Previous studies in New Zealand have lacked data on ethnicity. The aim of this study was to define the incidence and demographics of cSCC diagnosed in Northland, New Zealand, including data on ethnicity...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29770129/cutaneous-papillomaviruses-and-non-melanoma-skin-cancer-causal-agents-or-innocent-bystanders
#3
REVIEW
Daniel Hasche, Sabrina E Vinzón, Frank Rösl
There is still controversy in the scientific field about whether certain types of cutaneous human papillomaviruses (HPVs) are causally involved in the development of non-melanoma skin cancer (NMSC). Deciphering the etiological role of cutaneous HPVs requires - besides tissue culture systems - appropriate preclinical models to match the obtained results with clinical data from affected patients. Clear scientific evidence about the etiology and underlying mechanisms involved in NMSC development is fundamental to provide reasonable arguments for public health institutions to classify at least certain cutaneous HPVs as group 1 carcinogens...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29767233/potential-role-of-cyclin-f-mrna-expression-in-the-survival-of-skin-melanoma-patients-comprehensive-analysis-of-the-pathways-altered-due-to-cyclin-f-upregulation
#4
Maciej Gagat, Adrian Krajewski, Dariusz Grzanka, Alina Grzanka
Cyclin F is a part of the Skp, Cullin, F-box containing ligase complex. The activity of cyclin F includes cell cycle control, centrosome duplication and response to DNA damage. The cyclin F expression pattern is very similar to cyclin A, but cyclin F is an orphan cyclin without its cyclin-dependent kinase partner. There is little evidence concerning the role of cyclin F in cancer. In the present study, for the first time, we present analysis from The Cancer Genome Atlas (TCGA) data in the context of expression of cyclin F mRNA in melanoma patients...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29766934/spectrum-of-metastatic-neoplasms-of-the-brain-a-clinicopathological-study-in-a-tertiary-care-cancer-centre
#5
Smrita Singh, Usha Amirtham, Chennagiri S Premalata, Kuntegowdanahalli C Lakshmaiah, Lokesh Viswanath, Rekha V Kumar
Background: While brain metastases (BM) are the most common causes of neurologic disorders in patients with known systemic malignancies, they can often be the initial manifestations of an undetected primary elsewhere. BM are major causes of morbidity and mortality in cancer patients. Aims: We describe a mixed population (data from both retrospective and prospective collection) having a BM from a solid tumor. We report the percentage distribution of the most frequent types of BM, confirming the data published in the literature...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29764888/assessment-of-thyroid-cancer-risk-associated-with-radiation-dose-from-personal-diagnostic-examinations-in-a-cohort-study-of-us-radiologic-technologists-followed-1983-2014
#6
Mark P Little, Hyeyeun Lim, Melissa C Friesen, Dale L Preston, Michele M Doody, Alice J Sigurdson, Gila Neta, Bruce H Alexander, Lienard A Chang, Elizabeth K Cahoon, Steven L Simon, Martha S Linet, Cari M Kitahara
OBJECTIVE: To assess whether personal medical diagnostic procedures over life, but particularly those associated with exposure in adulthood, were associated with increased thyroid cancer risk. DESIGN: Participants from the US Radiologic Technologists Study, a large, prospective cohort, were followed from the date of first mailed questionnaire survey completed during 1983-1989 to the earliest date of self-reported diagnosis of thyroid cancer or of any other cancer than non-melanoma skin cancer (NMSC) in any of three subsequent questionnaires up to the last in 2012-2014...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764209/next-gen-therapeutics-for-skin-cancer-nutraceuticals
#7
Annapoorna Sreedhar, Jun Li, Yunfeng Zhao
Growing modernization and lifestyle changes with limited physical activity have impacted diet and health, leading to an increased cancer mortality rate worldwide. As a result, there is a greater need than before to develop safe and novel anticancer drugs. Current treatment options such as chemotherapy, radiotherapy and surgery, induce unintended side effects, compromising patient's quality of life, and physical well-being. Therefore, there has been an increased global interest in the use of dietary supplements and traditional herbal medicines for treatment of cancer...
May 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29763753/a-prospective-study-of-cancer-survivors-and-risk-of-sepsis-within-the-regards-cohort
#8
Justin Xavier Moore, Tomi Akinyemiju, Alfred Bartolucci, Henry E Wang, John Waterbor, Russell Griffin
BACKGROUND: Hospitalized cancer patients are nearly 10 times more likely to develop sepsis when compared to patients with no cancer history. We compared the risk of sepsis between cancer survivors and no cancer history participants, and examined whether race was an effect modifier. METHODS: We performed a prospective analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We categorized participants as "cancer survivors" or "no cancer history" derived from self-reported responses of being diagnosed with any cancer, excluding non-melanoma skin cancer...
May 11, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29763483/melanoma-in-us-hispanics-recommended-strategies-to-reduce-disparities-in-outcomes
#9
Valerie M Harvey
Cutaneous melanoma is the most fatal form of skin cancer and presents a considerable public health concern in the United States. Although the age-adjusted incidence of melanoma among US Hispanics is lower than that of non-Hispanic whites (NHWs), Hispanics who are diagnosed with melanoma are more likely to present with thicker primary tumors, metastatic disease, and lower 5-year melanoma-specific survival rates than NHWs. Melanoma risk factors and reasons for late presentation among Hispanics are not completely understood...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29762513/spatiotemporal-labeling-of-melanocytes-in-mice
#10
REVIEW
Sarah Preston, Shweta Aras, M Raza Zaidi
Melanocytes are pigment producing cells in the skin that give rise to cutaneous malignant melanoma, which is a highly aggressive and the deadliest form of skin cancer. Studying melanocytes in vivo is often difficult due to their small proportion in the skin and the lack of specific cell surface markers. Several genetically-engineered mouse models (GEMMs) have been created to specifically label the melanocyte compartment. These models give both spatial and temporal control over the expression of a cellular 'beacon' that has an added benefit of inducible expression that can be activated on demand...
May 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29762071/vla-4-mediated-adhesion-of-melanoma-cells-on-the-blood-brain-barrier-is-the-critical-cue-for-melanoma-cell-intercalation-and-barrier-disruption
#11
Ana B García-Martín, Pascale Zwicky, Thomas Gruber, Christoph Matti, Federica Moalli, Jens V Stein, David Francisco, Gaby Enzmann, Mitchell P Levesque, Ekkehard Hewer, Ruth Lyck
Melanoma is the most aggressive skin cancer in humans. One severe complication is the formation of brain metastasis, which requires extravasation of melanoma cells across the tight blood-brain barrier (BBB). Previously, VLA-4 has been assigned a role for the adhesive interaction of melanoma cells with non-BBB endothelial cells. However, the role of melanoma VLA-4 for breaching the BBB remained unknown. In this study, we used a mouse in vitro BBB model and imaged the shear resistant arrest of melanoma cells on the BBB...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29753256/new-antineoplastic-agent-based-on-a-dibenzoylmethane-derivative-cytotoxic-effect-and-direct-interaction-with-dna
#12
Fernanda R Nascimento, Tiago A Moura, Jefferson V P B Baeta, Bruno C Publio, Pollyanna M F Ferreira, Anésia A Santos, Andressa A P França, Marcio S Rocha, Gaspar Diaz-Muñoz, Marisa A N Diaz
Melanoma accounts for only 4% of all skin cancers but is among the most lethal cutaneous neoplasms. Dacarbazine is the drug of choice for the treatment of melanoma in Brazil through the public health system mainly because of its low cost. However, it is an alkylating agent of low specificity and elicits a therapeutic response in only 20% of cases. Other drugs available for the treatment of melanoma are expensive, and tumor cells commonly develop resistance to these drugs. The fight against melanoma demands novel, more specific drugs that are effective in killing drug-resistant tumor cells...
May 3, 2018: Biophysical Chemistry
https://www.readbyqxmd.com/read/29753063/knowledge-of-melanoma-and-non-melanoma-skin-cancer-among-general-dermatology-patients
#13
Adriane A Levin, Bichchau Michelle Nguyen
No abstract text is available yet for this article.
May 9, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29752876/quantifying-direct-dna-damage-in-the-basal-layer-of-skin-exposed-to-uv-radiation-from-sunbeds
#14
Isla Rose Mary Barnard, Patrick Tierney, Catherine Louise Campbell, Lewis McMillan, Harry Moseley, Ewan Eadie, Christian Tom Alcuin Brown, Kenneth Wood
Non-melanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the Cyclobutane Pyrimidine Dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo Radiative Transfer (MCRT) modelling to track the progression of UV photons through a multi-layered three dimensional (3D) grid that simulates the upper layers of the skin...
May 12, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29752800/raman-biophysical-markers-in-skin-cancer-diagnosis
#15
Xu Feng, Austin J Moy, Hieu T M Nguyen, Yao Zhang, Jason Zhang, Matthew C Fox, Katherine R Sebastian, Jason S Reichenberg, Mia K Markey, James W Tunnell
Raman spectroscopy (RS) has demonstrated great potential for in vivo cancer screening; however, the biophysical changes that occur for specific diagnoses remain unclear. We recently developed an inverse biophysical skin cancer model to address this issue. Here, we presented the first demonstration of in vivo melanoma and nonmelanoma skin cancer (NMSC) detection based on this model. We fit the model to our previous clinical dataset and extracted the concentration of eight Raman active components in 100 lesions in 65 patients diagnosed with malignant melanoma (MM), dysplastic nevi (DN), basal cell carcinoma, squamous cell carcinoma, and actinic keratosis...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29750461/psycho-oncological-care-of-melanoma-patients-in-certified-skin-cancer-centers
#16
Frank Meiss, Carmen Loquai, Joachim Weis, Jürgen M Giesler, Katrin Reuter, Dorothée Nashan
BACKGROUND: The establishment und certification of skin cancer centers (SCCs) in compliance with requirements issued by the German Cancer Society play a key role for quality-assured treatment of skin cancer patients. These requirements also call for the implementation of a qualified psycho-oncology program. When planning the present study, we assumed site-specific differences in the way such programs were implemented at various SCCs. METHODS: In 2014, we conducted a cross-sectional survey of all SCCs certified at the time (n = 43), in which these institutions were asked to provide information on the structural and process quality of their psycho-oncology programs...
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29746279/free-style-capillary-perforator-based-island-flaps-for-reconstruction-of-skin-cancer-defects-of-the-face-body-and-extremities
#17
Giuseppe Visconti, Marzia Salgarello
BACKGROUND: The perforator flap concept has revolutionized reconstructive surgery. Recently, the attention has moved toward flaps based on capillary perforators, which have been usually neglected in the past as reliable perforators. The aim of this article is to report a series of freestyle capillary perforator-based island flap (c-PBIF) for reconstruction of skin cancer defects of the face, body, and extremities. PATIENTS AND METHODS: Between September 2015 and July 2017, 20 consecutive patients underwent c-PBIF reconstruction of facial, body, and limb defects after melanoma and nonmelanoma skin cancer excision...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29743371/roles-of-fc-domain-and-exudation-in-l2-antibody-mediated-protection-against-human-papillomavirus
#18
Joshua W Wang, Wai Hong Wu, Tsui-Chin Huang, Margaret Wong, Kihyuck Kwak, Keiko Ozato, Chien-Fu Hung, Richard B S Roden
To address how L2-specific antibodies prevent human papillomavirus (HPV) infection of the genital tract we generated neutralizing monoclonal antibodies (MAbs) WW1, a rat IgG2a that binds L2 residues 17-36 (like mouse MAb RG1), and JWW3, a mouse IgG1 derivative of Mab24 specific to L2 residues 58-64. By Western blot, WW1 recognized L2 of 29/34 HPV genotypes tested, compared to only 13/34 for RG1, and 25/34 for JWW3. WW1 IgG and (Fab')2 bound HPV16 pseudovirions similarly, however whole IgG provided better protection against HPV vaginal challenge...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29739929/genome-wide-association-study-in-176-678-europeans-reveals-genetic-loci-for-tanning-response-to-sun-exposure
#19
Alessia Visconti, David L Duffy, Fan Liu, Gu Zhu, Wenting Wu, Yan Chen, Pirro G Hysi, Changqing Zeng, Marianna Sanna, Mark M Iles, Peter A Kanetsky, Florence Demenais, Merel A Hamer, Andre G Uitterlinden, M Arfan Ikram, Tamar Nijsten, Nicholas G Martin, Manfred Kayser, Tim D Spector, Jiali Han, Veronique Bataille, Mario Falchi
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability...
May 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29734747/visible-and-extended-near-infrared-multispectral-imaging-for-skin-cancer-diagnosis
#20
Laura Rey-Barroso, Francisco J Burgos-Fernández, Xana Delpueyo, Miguel Ares, Santiago Royo, Josep Malvehy, Susana Puig, Meritxell Vilaseca
With the goal of diagnosing skin cancer in an early and noninvasive way, an extended near infrared multispectral imaging system based on an InGaAs sensor with sensitivity from 995 nm to 1613 nm was built to evaluate deeper skin layers thanks to the higher penetration of photons at these wavelengths. The outcomes of this device were combined with those of a previously developed multispectral system that works in the visible and near infrared range (414 nm⁻995 nm). Both provide spectral and spatial information from skin lesions...
May 5, 2018: Sensors
keyword
keyword
13703
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"