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https://www.readbyqxmd.com/read/28544818/ubiquitination-in-melanoma-pathogenesis-and-treatment
#1
REVIEW
Jinyuan Ma, Weinan Guo, Chunying Li
Melanoma is one of the most aggressive skin cancers with fiercely increasing incidence and mortality. Since the progressive understanding of the mutational landscape and immunologic pathogenic factors in melanoma, the targeted therapy and immunotherapy have been recently established and gained unprecedented improvements for melanoma treatment. However, the prognosis of melanoma patients remains unoptimistic mainly due to the resistance and nonresponse to current available drugs. Ubiquitination is a posttranslational modification which plays crucial roles in diverse cellular biological activities and participates in the pathogenesis of various cancers, including melanoma...
May 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28543886/human-hairless-protein-roles-in-skin-hair-and-emerging-connections-to-brain-and-other-cancers
#2
Anas Maatough, G Kerr Whitfield, Lemlem Brook, David Hsieh, Patricia Palade, Jui-Cheng Hsieh
The mammalian hairless protein (HR) is a 130 kDa nuclear transcription factor that is essential for proper skin and hair follicle function. Previous studies have focused on the role of HR in skin maintenance and hair cycling. However, hairless gene (HR) is also expressed in brain and other tissues, where its role remains poorly understood. HR has been reported to contain functional domains that potentially serve in DNA binding, histone demethylation, nuclear translocation signal, and protein-protein interactions...
May 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28542543/knowledge-deficit-attitude-and-behavior-scales-association-to-objective-measures-of-sun-exposure-and-sunburn-in-a-danish-population-based-sample
#3
Brian Køster, Jens Søndergaard, Jesper Bo Nielsen, Karl Bang Christensen, Martin Allen, Anja Olsen, Joan Bentzen
The objective of this study was to develop new scales measuring knowledge and attitude about UVR and sun related behavior, and to examine their association to sun related behavior objectively measured by personal dosimetry. During May-August 2013, 664 Danes wore a personal electronic UV-dosimeter for one week that measured their UVR exposure. Afterwards, they answered a questionnaire on sun-related items. We applied descriptive analysis, linear and logistic regression analysis to evaluate the associations between the questionnaire scales and objective UVR measures...
2017: PloS One
https://www.readbyqxmd.com/read/28541267/choroidal-melanoma-sector-melanocytosis-and-retinal-pigment-epithelial-microdetachments-in-birt-hogg-dub%C3%A3-syndrome
#4
Charlotte L Marous, Molly R Marous, R Joel Welch, Jerry A Shields, Carol L Shields
PURPOSE: Birt-Hogg-Dubé Syndrome (BHDS) is a rare autosomal dominant condition that can predispose patients to numerous cutaneous fibrofolliculomas and other cutaneous lesions, pulmonary cysts with spontaneous pneumothorax, and multifocal renal tumors and cancer. The genetic mutations responsible for BHDS are related to tumor suppression and the mammalian target of rapamycin (mTOR) pathway. Previous reports of the ocular findings in BHDS include eyelid fibrofolliculomas, "flecked chorioretinopathy," and one report of choroidal melanoma...
May 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28538880/prevalence-of-photoprotection-and-its-associated-factors-in-risk-group-for-skin-cancer-in-teresina-piau%C3%A3
#5
Fernanda Ayres de Morais E Silva Cardoso, Gerardo Vasconcelos Mesquita, Viriato Campelo, Maria do Carmo de Carvalho E Martins, Camila Aparecida Pinheiro Landim Almeida, Regina Silva Rabelo, Amanda Eugênia Almeida Rocha, Jadson Lener Oliveira Dos Santos
Background: The incidence of skin cancer has increased worldwide, particularly melanoma rates, which had a mean development of 2.6 % a year in the last 10 years. The agreement on the relation between long-term or chronic exposure to the sun and the emergence of these neoplasias has made several workers who perform activities exposed to solar radiation to form a risk group for the development of skin cancer, community health agents included. OBJECTIVES: To analyze the prevalence of sunscreen-use-related factors to skin cancer in a labor risk group...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28535466/do-polychlorinated-biphenyls-cause-cancer-a-systematic-review-and-meta-analysis-of-epidemiological-studies-on-risk-of-cutaneous-melanoma-and-non-hodgkin-lymphoma
#6
REVIEW
Claudia Zani, Elisabetta Ceretti, Loredana Covolo, Francesco Donato
In 2015 a IARC Working Group upgraded the classification of PCBs to Group 1 "Carcinogenic to humans", also on the basis of evidence from epidemiological studies showing an excess risk for melanoma. Increased risks for non-Hodgkin lymphoma (NHL) and breast cancer were also reported though the evidence was limited. However, some recent reviews of studies on PCB exposure and risk of cancer provided discrepant findings. Therefore, we re-evaluated the association between exposure to PCBs and risk of melanoma and NHL by a systematic review and meta-analysis...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28534532/skin-cancer-mutational-landscape-of-melanoma-revealed
#7
Peter Sidaway
No abstract text is available yet for this article.
May 23, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28531887/expression-and-characterization-of-membrane-type-4-matrix-metalloproteinase-mt4-mmp-and-its-different-forms-in-melanoma
#8
Bettina Hieronimus, Julian Pfohl, Christian Busch, Lutz Graeve
BACKGROUND/AIMS: Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis. Two of the six known MT-MMPs are anchored to the plasma membrane via a GPI anchor, one of which is MT4-MMP. Only little is known about MT4-MMP expression, synthesis, regulation and degradation. METHODS: We analyzed several human cancer cell lines as well as tissue homogenates using Western blotting and quantitative PCR for the expression of MT4-MMP...
May 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28528915/sphingosine-metabolism-as-a-therapeutic-target-in-cutaneous-melanoma
#9
REVIEW
Mohammed Dany
Melanoma is by far the most aggressive type of skin cancer with a poor prognosis in its advanced stages. Understanding the mechanisms involved in melanoma pathogenesis, response, and resistance to treatment has gained a lot of attention worldwide. Recently, the role of sphingolipid metabolism has been studied in cutaneous melanoma. Sphingolipids are bioactive lipid effector molecules involved in the regulation of various cellular signaling pathways such as inflammation, cancer cell proliferation, death, senescence, and metastasis...
May 4, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28526240/endocrine-actions-of-vitamin-d-in-skin-relevance-for-photocarcinogenesis-of-non-melanoma-skin-cancer-and-beyond
#10
REVIEW
Jörg Reichrath, Roman Saternus, Thomas Vogt
The skin represents a pivotal organ for the human body's vitamin D endocrine system, being both the site of ultraviolet (UV)-B-induced vitamin D synthesis and a target tissue for the pluripotent effects of 1,25(OH)2D3 and other biologically active vitamin D metabolites. As many other steroid hormones, 1,25(OH)2D3 exerts its effects via two independent signal transduction pathways: the classical genomic and the non-genomic pathway. While non-genomic effects of 1,25(OH)2D3 are in part exerted via effects on intracellular calcium, genomic effects are mediated by the vitamin D receptor (VDR)...
May 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28524053/reduced-frequency-of-non-melanoma-skin-cancer-in-72-739-patients-with-psoriasis-a-retrospective-study
#11
Andrea Paradisi, Biagio Didona, Stefano Tabolli, Francesco Ricci, Luciano Sobrino, Annarita Panebianco, Damiano Abeni
Chronic inflammatory conditions, such as psoriasis, may pose an increased risk of cancer due to impaired immunosurveillance resulting from chronic inflammation and immunosuppressive medications. To compare the risk of non-melanoma skin cancer (NMSC) in a retrospective cohort of 72,739 psoriasis patients and 25,956 non-dermatological patients. A record linkage was performed for data on hospitalizations, and the occurrence of NMSC was compared by computing the relative risk (RR) and modelled using multiple logistic regression...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28521479/association-between-non-melanoma-and-melanoma-skin-cancer-rates-vitamin-d-and-latitude
#12
Miguel Rivas, Elisa Rojas, Gloria M Calaf, Marcela Barberán, Claudio Liberman, Marcelo De Paula Correa
Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28516187/-the-aged-scalp-a-dermato-oncological-focus-point
#13
REVIEW
N Wroblewski, K Wylon, C Ulrich
Non-melanoma skin cancer and its precursor lesions are common diagnoses in dermatological practice, due to rising incidence and prevalence. Diagnosis is often clinical with subsequent histological confirmation. First-choice treatment for invasive carcinomas is complete surgical excision. Other therapeutic options, such as radiation or systemic therapies, should only be considered when excision is impossible. Mostly located on parts of the scalp that are poorly visible and accessible, particularly for elderly patients, these lesions are a challenge for physicians and patients alike...
May 17, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28515985/epidemiological-trends-in-skin-cancer
#14
Zoe Apalla, Aimilios Lallas, Elena Sotiriou, Elizabeth Lazaridou, Demetrios Ioannides
Skin cancer, including melanoma and non-melanoma skin cancer (NMSC), represents the most common type of malignancy in the white population. The incidence rate of melanoma is increasing worldwide, while the associated mortality remains stable, or is slightly decreasing. On the other hand, the incidence for NMSC varies widely, with the highest rates reported in Australia. In the current review, we highlight recent global trends in epidemiology of skin cancer. We discuss controversial issues raised in current epidemiological data, we analyze the most important risk factors associated with the development of melanoma and NMSC and the impact of skin cancer on health care services...
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28513818/the-risk-of-melanoma-associated-with-ambient-summer-ultraviolet-radiation
#15
Lauren Pinault, Tracey Bushnik, Vitali Fioletov, Cheryl E Peters, Will D King, Michael Tjepkema
BACKGROUND: Depletion of the ozone layer has meant that ambient ultraviolet radiation (UVR) has increased in recent decades. At the same time, the incidence of skin cancers, including melanoma, has risen. The relatively few large-scale studies that linked ambient UVR to melanoma found a trend toward rising incidence closer to the equator, where UVR estimates are highest. Similar research has not been conducted in Canada, where ambient UVR is generally lower than in countries further south...
May 17, 2017: Health Reports
https://www.readbyqxmd.com/read/28512869/patterns-of-head-and-neck-sarcoma-in-australia
#16
Roger H Woods, J Alexa Potter, Jessica L Reid, Jennie Louise, Taryn Bessen, Gelareh Farshid, Susan J Neuhaus
BACKGROUND: Sarcomas affecting the head and neck often require complex management due to the combination of anatomic, aesthetic and oncological considerations. The incidence and patterns of presentation are poorly understood and have not been reviewed in the Australian population. METHOD: This study sourced incidence and demographic data from the National Cancer Registry at the Australian Institute of Health and Welfare for the years 1982-2009 (corresponding to 97...
May 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28512610/melanoma-is-skin-deep-a-3d-reconstruction-technique-for-computerized-dermoscopic-skin-lesion-classification
#17
T Y Satheesha, D Satyanarayana, M N Giri Prasad, Kashyap D Dhruve
Melanoma mortality rates are the highest amongst skin cancer patients. Melanoma is life threating when it grows beyond the dermis of the skin. Hence, depth is an important factor to diagnose melanoma. This paper introduces a non-invasive computerized dermoscopy system that considers the estimated depth of skin lesions for diagnosis. A 3-D skin lesion reconstruction technique using the estimated depth obtained from regular dermoscopic images is presented. On basis of the 3-D reconstruction, depth and 3-D shape features are extracted...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28507493/comparison-of-the-incidence-of-skin-cancers-in-patients-on-dialysis-and-after-kidney-transplantation
#18
Joanna Sułowicz, Anna Wojas-Pelc, Ewa Ignacak, Katarzyna Krzanowska, Marek Kuźniewski, Władysław Sułowicz
INTRODUCTION: Kidney transplant (KTx) patients on immunosuppressive therapy are predisposed to the development of infections and cancers. AIM: To compare the incidence and type of malignant skin lesions in kidney transplant patients and the dialyzed population based on the initiated dermatologic screening. MATERIAL AND METHODS: The study included 598 patients: 486 kidney transplant recipients and 112 patients on maintenance dialysis. All the patients underwent dermatological examination...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28501937/expression-of-pd-l1-in-keratoacanthoma-and-different-stages-of-progression-in-cutaneous-squamous-cell-carcinoma
#19
Thilo Gambichler, Martha Gnielka, Ines Rüddel, Eggert Stockfleth, Markus Stücker, Lutz Schmitz
BACKGROUND: Programmed cell death 1 (PD-1) and its ligands (PD-L1) play a major role in the immune responses of a variety of cancers. OBJECTIVES: To investigate the expression of PD-L1 in different progression forms of cutaneous squamous cell carcinoma (cSCC) and keratoacanthoma (KA). METHODS: We performed immunohistochemical staining of 21 KA, 26 actinic keratoses (AK), 20 Bowen´s diseases (BD), and 26 high-risk cSCC. The staining patterns were assessed using the tumour proportion score and staining intensity evaluation...
May 13, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28500276/while-reinforcing-cell-cycle-arrest-rapamycin-and-torins-suppress-senescence-in-uva-irradiated-fibroblasts
#20
Olga V Leontieva, Mikhail V Blagosklonny
Sunlight predisposes to skin cancer and melanomas. Ultraviolet A (UVA), a long wave component of sunlight, can reach dermal fibroblasts. Here we studied UVA-induced senescence in human fibroblasts in vitro. It is known that senescence occurs, when cell cycle is arrested, but mTOR is still active, thus converting arrest to senescence (geroconversion). We showed that, while arresting cell cycle, UVA did not inhibit mTOR, enabling geroconversion. In UVA-treated cells, mTOR remained fully active. Rapamycin and Torins 1/ 2 prevented UVA-induced senescent phenotype, although they further re-enforced cell cycle arrest...
May 11, 2017: Oncotarget
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