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https://www.readbyqxmd.com/read/28108254/changes-in-pitch-height-elicit-both-language-universal-and-language-dependent-changes-in-neural-representation-of-pitch-in-the-brainstem-and-auditory-cortex
#1
Ananthanarayan Krishnan, Chandan H Suresh, Jackson T Gandour
Language experience shapes encoding of pitch-relevant information at both brainstem and cortical levels of processing. Pitch height is a salient dimension that orders pitch from low to high. Herein we investigate the effects of language experience (Chinese, English) in the brainstem and cortex on i) neural responses to variations in pitch height, ii) presence of asymmetry in cortical pitch representation, and iii) patterns of relative changes in magnitude of pitch height between these two levels of brain structure...
January 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28089233/epicardial-adipose-tissue-and-myocardial-ischemia-assessed-by-computed-tomography-perfusion-imaging-and-invasive-fractional-flow-reserve
#2
Rahul G Muthalaly, Nitesh Nerlekar, Dennis T L Wong, James D Cameron, Sujith K Seneviratne, Brian S Ko
BACKGROUND: Epicardial adipose tissue (EAT) is a metabolically active fat depot that is associated with incident coronary artery disease (CAD) and major adverse cardiovascular events. The relationship between EAT and myocardial ischemia remains unclear. This study investigated the relationship between EAT volume and the presence of perfusion defects on myocardial computed tomographic perfusion imaging (CTP) and functional stenoses on invasive fractional flow-reserve (FFR). METHODS: Data were obtained from a previous prospective cross-sectional study in patients with suspected CAD...
December 30, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28086778/diabetes-does-not-impact-the-diagnostic-performance-of-contrast-based-fractional-flow-reserve-insights-from-the-contrast-study
#3
Giuseppe Gargiulo, Eugenio Stabile, Marco Ferrone, Emanuele Barbato, Frederik M Zimmermann, Julien Adjedj, Barry Hennigan, Mitsuaki Matsumura, Nils P Johnson, William F Fearon, Allen Jeremias, Bruno Trimarco, Giovanni Esposito
BACKGROUND: Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in patients with diabetes. METHODS: We performed a post-hoc analysis of the CONTRAST study, which prospectively enrolled an international cohort of patients undergoing routine fractional flow reserve (FFR) assessment for standard indications. Paired, repeated measurements of all physiology metrics (Pd/Pa, iFR, contrast-based FFR, and FFR) were made...
January 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28048767/su-f-i-77-radiation-dose-in-cardiac-catheterization-procedures-impact-of-a-systematic-reduction-in-pulsed-fluoroscopy-frame-rate
#4
C Schultz, S Dixon
PURPOSE: To evaluate whether one small systematic reduction in fluoroscopy frame rate has a significant effect on the total air kerma and/or dose area product for diagnostic and interventional cardiac catheterization procedures. METHODS: The default fluoroscopy frame rate (FFR) was lowered from 15 to 10 fps in 5 Siemens™ Axiom Artis cardiac catheterization labs (CCL) on July 1, 2013. A total of 7212 consecutive diagnostic and interventional CCL procedures were divided into two study groups: 3602 procedures from 10/1/12 -6/30/13 with FFR of 15 fps; and 3610 procedures 7/1/13 - 3/31/14 at 10 fps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047187/tu-h-campus-iep2-03-development-of-3d-printed-coronary-phantoms-for-in-vitro-ct-ffr-validation-using-data-from-320-detector-row-coronary-ct-angiography
#5
C Ionita, E Angel, D Mitsouras, S Rudin, D Bednarek, S Zaid, M Wilson, F Rybicki
PURPOSE: To validate Computed Tomography Fractional Flow Reserve (CT-FFR) measurements with accurate 3D printed coronary phantoms. METHODS: DICOM data from four phases in two patients imaged with a standard 320 × 0.5mm coronary CT acquisition (70-80% cardiac cycle) underwent semi-automated segmentation using a research workstation. Both patients had a >50% stenosis from the clinical image interpretation. Each volume was saved as a Stereo Lithographic (STL) file with 250 micron resolution...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044265/improvement-of-subjective-well-being-by-ranolazine-in-patients-with-chronic-angina-and-known-myocardial-ischemia-imwell-study
#6
Anthony A Bavry, Ki E Park, Calvin Y Choi, Ahmed N Mahmoud, Xuerong Wen, Islam Y Elgendy
INTRODUCTION: We aimed to assess if ranolazine would improve angina symptoms among patients with documented myocardial ischemia. METHODS: Eligible subjects had chronic stable angina and at least one coronary stenosis with fractional flow reserve (FFR) ≤0.80 or at least one chronic total occlusion (CTO) without attempted revascularization. Subjects were randomized to oral ranolazine 500 mg twice daily for 1 week, then ranolazine 1000 mg twice daily for 15 weeks versus matching placebo...
January 2, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28043881/simultaneously-evoked-auditory-potentials-seap-a-new-method-for-concurrent-measurement-of-cortical-and-subcortical-auditory-evoked-activity
#7
Christopher Slugocki, Daniel Bosnyak, Laurel J Trainor
Recent electrophysiological work has evinced a capacity for plasticity in subcortical auditory nuclei in human listeners. Similar plastic effects have been measured in cortically-generated auditory potentials but it is unclear how the two interact. Here we present Simultaneously-Evoked Auditory Potentials (SEAP), a method designed to concurrently elicit electrophysiological brain potentials from inferior colliculus, thalamus, and primary and secondary auditory cortices. Twenty-six normal-hearing adult subjects (mean 19...
December 30, 2016: Hearing Research
https://www.readbyqxmd.com/read/28040284/outcome-of-coronary-lesions-with-deferred-revascularization-due-to-negative-fractional-flow-reserve-in-subjects-with-acute-coronary-syndrome
#8
Andrea Picchi, Antonio Maria Leone, Filippo Zilio, Enrico Cerrato, Fabrizio D'Ascenzo, Massimo Fineschi, Stefano Rigattieri, Marco Ferlini, Matteo Cameli, Paolo Calabria, Alberto Cresti, Ugo Limbruno
OBJECTIVE: Revascularization of functionally non-significant stenoses in patients with stable coronary artery disease can safely be deferred as rate of adverse cardiovascular events is low. It is not clear whether fractional flow reserve (FFR) is just as accurate in acute coronary syndromes (ACS). The aim of this study is to assess the outcome of coronary lesions whose revascularization was deferred based on negative FFR values in subjects with ACS. METHODS: Patients with acute coronary syndrome and showing at least one coronary stenosis whose revascularization was deferred based on FFR value >0...
December 22, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28025461/biphasic-force-frequency-relation-predicts-primary-cardiac-events-in-patients-with-hypertrophic-cardiomyopathy
#9
Ryota Morimoto, Takahiro Okumura, Yasuko K Bando, Kenji Fukaya, Akinori Sawamura, Haruya Kawase, Shinya Shimizu, Shuzo Shimazu, Akihiro Hirashiki, Kyosuke Takeshita, Toyoaki Murohara
BACKGROUND: The force-frequency relation (FFR) is a hemodynamic index of the chronotropic relationship between left ventricular (LV) systolic function (percent change in dP/dtmax) and elevation of heart rate. FFR is a marker of myocardial contractile reserve and follows an upward slope in healthy myocardium [monophasic FFR (MoF)], a pattern that becomes biphasic (BiF) under pathological conditions. However, it remains uncertain whether the FFR determines a patient's prognosis. We investigated the promising role of the FFR as a predictor of cardiac events in the setting of hypertrophic cardiomyopathy (HCM)...
December 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28025191/fractional-flow-reserve-to-guide-and-to-assess-coronary-artery-bypass-grafting
#10
REVIEW
Mariano Pellicano, Bernard De Bruyne, Gabor G Toth, Filip Casselman, William Wijns, Emanuele Barbato
The aim of this review is to highlight the role of invasive functional evaluation in patients in whom coronary artery bypass graft (CABG) is indicated, and to examine the clinical evidence available in favour of fractional flow reserve (FFR) adoption in these patients, outline appropriate use, as well as point out potential pitfalls. FFR after CABG will also be reviewed, highlighting its correct interpretation and adoption when applied to both native coronary arteries and bypass grafts. Practice European guidelines support the use of FFR to complement coronary angiography with the highest degree of recommendation (Class IA) for the assessment of coronary stenosis before undertaking myocardial revascularization when previous non-invasive functional evaluation is unavailable or not conclusive...
December 23, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28013282/fractional-flow-reserve-derived-from-coronary-computed-tomography-angiography-diagnostic-performance-in-hypertensive-and-diabetic-patients
#11
Ashkan Eftekhari, James Min, Stephan Achenbach, Mohamed Marwan, Matthew Budoff, Jonathon Leipsic, Sara Gaur, Jesper Møller Jensen, Brian S Ko, Evald Høj Christiansen, Anne Kaltoft, Hans Erik Bøtker, Jens Flensted Jensen, Bjarne Linde Nørgaard
AIMS: Fractional flow reserve (FFR) derived from coronary computed tomography (FFRCT) has high diagnostic performance in stable coronary artery disease (CAD). The diagnostic performance of FFRCT in patients with hypertension (HTN) and diabetes (DM), who are at risk of microvascular impairment, is not known. METHODS AND RESULTS: We analysed the diagnostic performance of FFRCT, in patients (vessels) with DM (n = 16), HTN (n = 186), DM + HTN (n = 58) vs...
December 24, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28007742/invasive-minimal-microvascular-resistance-is-a-new-index-to-assess-microcirculatory-function-independent-of-obstructive-coronary-artery-disease
#12
Guus A de Waard, Sukhjinder S Nijjer, Martijn A van Lavieren, Nina W van der Hoeven, Ricardo Petraco, Tim P van de Hoef, Mauro Echavarría-Pinto, Sayan Sen, Peter M van de Ven, Paul Knaapen, Javier Escaned, Jan J Piek, Justin E Davies, Niels van Royen
BACKGROUND: Coronary microcirculatory dysfunction portends a poor cardiovascular outcome. Invasive assessment of microcirculatory dysfunction by coronary flow reserve (CFR) and hyperemic microvascular resistance (HMR) is affected by coronary artery disease (CAD). In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. METHODS AND RESULTS: We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28004229/patient-specific-3d-hemodynamics-modelling-of-left-coronary-artery-under-hyperemic-conditions
#13
Sarfaraz Kamangar, Irfan Anjum Badruddin, Kalimuthu Govindaraju, N Nik-Ghazali, A Badarudin, Girish N Viswanathan, N J Salman Ahmed, T M Yunus Khan
The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle...
December 21, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27998839/ffr-result-post-pci-is-suboptimal-in-long-diffuse-coronary-artery-disease
#14
Arvydas Baranauskas, Aaron Peace, Aleksandras Kibarskis, Joanne Shannon, Vytautas Abraitis, Vilhelmas Bajoras, Valdas Bilkis, Audrius Aidietis, Aleksandras Laucevicius, Giedrius Davidavicius
AIMS: The aim of this study was to evaluate the functional result immediately post PCI and at nine-month follow-up, and to ascertain how often a functionally optimal result of >0.95 can be achieved in long coronary lesions treated with long second- or newer-generation DES. METHODS AND RESULTS: Patients receiving DES measuring ≥30 mm with FFR value ≤0.8 were included in the study. Stent length was defined as long (30 to 49 mm; L-DES) and ultra-long (≥50 mm; UL-DES)...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27993753/reactive-myocardial-hyperemia-for-functional-assessment-of-coronary-stenosis-severity
#15
Michael Stoller, Christian Seiler
AIM: To compare functional assessment of coronary stenosis severity by fractional flow reserve (FFR) measurement as induced by systemic adenosine and by regional reactive myocardial hyperemia. METHODS AND RESULTS: The primary study endpoints were coronary pressure-derived FFR values in response to intravenous adenosine infusion (140µg/min/kg) and to a 1-minute proximal coronary artery balloon occlusion (reactive hyperemia) for the same stenosis of interest. The secondary study endpoint was coronary collateral flow index (CFI) during the same occlusion...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27983573/trends-in-consumption-of-solid-fats-added-sugars-sodium-sugar-sweetened-beverages-and-fruit-from-fast-food-restaurants-and-by-fast-food-restaurant-type-among-us-children-2003-2010
#16
Colin D Rehm, Adam Drewnowski
Energy intakes from fast food restaurants (FFRs) have declined among US children. Less is known about the corresponding trends for FFR-sourced solid fats, added sugars, and sodium, and food groups of interest, such as fruit and sugar-sweetened beverages (SSBs). Using data from a single 24-h dietary recall among 12,378 children aged 4-19 years from four consecutive cycles of the nationally-representative National Health and Nutrition Examination Survey (NHANES), 2003-2010 a custom algorithm segmented FFRs into burger, pizza, sandwich, Mexican cuisine, chicken, Asian cuisine, fish restaurants, and coffee shops...
December 13, 2016: Nutrients
https://www.readbyqxmd.com/read/27982159/comparative-study-between-perfusion-changes-and-positive-findings-on-coronary-flow-reserve
#17
Costantino Roberto Frack Costantini, Jose Antonio Ramires, Costantino Ortiz Costantini, Marcos Antonio Denk, Sergio Gustavo Tarbine, Marcelo de Freitas Santos, Daniel Aníbal Zanuttini, Carmen Weigert Silveira, Admar Moraes de Souza, Rafael Michel de Macedo
Background: Functional assessment of coronary artery obstruction is used in cardiology practice to correlate anatomic obstructions with flow decrease. Among such assessments, the study of the coronary fractional flow reserve (FFR) has become the most widely used. Objective: To evaluate the correlation between FFR and findings of ischemia obtained by noninvasive methods including stress echocardiography and nuclear medicine and the presence of critical coronary artery obstruction...
December 8, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27980112/cortical-correlates-of-the-auditory-frequency-following-and-onset-responses-eeg-and-fmri-evidence
#18
Emily B J Coffey, Gabriella Musacchia, Robert J Zatorre
: The frequency following response (FFR) is a measure of the brain's periodic sound encoding. It is of increasing importance for studying the human auditory nervous system due to numerous associations with auditory cognition and dysfunction. Although the FFR is widely interpreted as originating from brainstem nuclei, a recent study using magnetoencephalography (MEG) suggested that there is also a right-lateralized contribution from the auditory cortex at the fundamental frequency (Coffey et al...
December 15, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27979031/clinical-value-of-post-percutaneous-coronary-intervention-fractional-flow-reserve-value-a-systematic-review-and-meta-analysis
#19
REVIEW
Goran Rimac, William F Fearon, Bernard De Bruyne, Fumiaki Ikeno, Hitoshi Matsuo, Zsolt Piroth, Olivier Costerousse, Olivier F Bertrand
BACKGROUND: Fractional flow reserve (FFR) prior to percutaneous coronary intervention (PCI) is useful to guide treatment. Whether post-PCI FFR assessment might have clinical impact is controversial. The aim of this study is to evaluate the range of post-PCI FFR values and analyze the relationship between post-PCI FFR and clinical outcomes. METHODS: We systematically searched the PubMed, EMBASE, and Cochrane Library databases with cross-referencing of articles reporting post-PCI FFR and correlating post-PCI FFR values and clinical outcomes...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27973333/reliability-of-physiological-assessment-of-coronary-stenosis-severity-using-intracoronary-pressure-techniques-a-comprehensive-analysis-from-a-large-cohort-of-consecutive-intermediate-coronary-lesions
#20
Fernando Rivero, Javier Cuesta, Teresa Bastante, Amparo Benedicto, Cristina Fernández-Pérez, Paula Antuña, Marcos García-Guimaraes, Fernando Alfonso
AIM: We sought to assess the reliability of the most frequently used intracoronary physiologic indexes (including intravenous adenosine-FFR [IV- FFR], intracoronary low-dose-adenosine FFR [IC-LD-FFR], intracoronary high- dose-adenosine FFR [IC-HD-FFR], Pd/Pa and iFR). We also sought to analyze factors affecting their reproducibility in a real world patient population. METHODS AND RESULTS: A total of 91 lesions in 86 consecutive patients were included. Measurements of all physiological indexes were repeated within a systematic standardized prospective protocol...
December 15, 2016: EuroIntervention
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