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Osteoarthritis

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https://www.readbyqxmd.com/read/30025378/differences-in-pain-and-function-between-adolescent-athletes-and-physically-active-non-athletes-with-patellofemoral-pain
#1
Amanda Schenatto Ferreira, Danilo de Oliveira Silva, Liliam Barbuglio Del Priore, Carmen Lucia Gomes Garcia, Matheus Henrique Maiolini Ducatti, Ana Flavia Balotari Botta, Marina Cabral Waiteman, Fábio Mícolis de Azevedo
OBJECTIVES: To investigate pain level and function limitation in adolescent athletes and physically active non-athletes with PFP. DESIGN: Cross-sectional study. SETTING: Adolescent athletes were recruited at a sport center complex. Adolescent non-athletes were recruited from upper secondary schools. PARTICIPANTS: 108 adolescents diagnosed with PFP: 42 adolescent athletes and 66 adolescent non-athletes. MAIN OUTCOME MEASURES: To evaluate the level of pain, a visual analog scale (VAS) was used and to evaluate the overall function, the Knee Outcome in Osteoarthritis Survey (KOOS) was used...
July 11, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/30024275/circulating-and-synovial-fluid-heat-shock-protein-70-are-correlated-with-severity-in-knee-osteoarthritis
#2
Srihatach Ngarmukos, Shaun Scaramuzza, Nipaporn Theerawattanapong, Aree Tanavalee, Sittisak Honsawek
Objective Heat shock proteins are molecules rapidly produced under conditions of environmental stress, and involve in protecting the cells structural integrity and function. Osteoarthritis (OA) is a chronic destructive disorder of the joints manifested by the ongoing deterioration and loss of articular cartilage. The present study aimed to analyze circulating and synovial heat shock protein (Hsp70) values in knee osteoarthritis patients and healthy controls and to determine their relationship with the radiographic grading of the severity of knee OA...
July 1, 2018: Cartilage
https://www.readbyqxmd.com/read/30023361/pooled-platelet-rich-plasma-lysate-therapy-increases-synoviocyte-proliferation-and-hyaluronic-acid-production-while-protecting-chondrocytes-from-synoviocyte-derived-inflammatory-mediators
#3
Jessica M Gilbertie, Julie M Long, Alicia G Schubert, Alix K Berglund, Thomas P Schaer, Lauren V Schnabel
Platelet-rich plasma (PRP) preparations are being used with moderate success to treat osteoarthritis (OA) in humans and in veterinary species. Such preparations are hindered, however, by being autologous in nature and subject to tremendous patient and processing variability. For this reason, there has been increasing interest in the use of platelet lysate preparations instead of traditional PRP. Platelet lysate preparations are acellular, thereby reducing concerns over immunogenicity, and contain high concentrations of growth factors and cytokines...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/30023332/an-investigation-on-the-regenerative-effects-of-intra-articular-injection-of-co-cultured-adipose-derived-stem-cells-with-chondron-for-treatment-of-induced-osteoarthritis
#4
Sorayya Jacer, Hajar Shafaei, Jafar Soleimani Rad
Purpose: Adipose tissue derived stem cells (ASCs) and chondrocytes are best cells for articular cartilage regeneration. Chondrocyte with peri-cellular matrix (PCM) is called chondron provides ideal microenviroment than chondrocytes. We aimed to evaluate the regenerative effects of intra-articular injection of ASCs co-cultures with chondron in induced osteoarthritis (OA). Methods: ASC, from the peri-renal fat of male rat and chondron from primary newborn rat hyaline cartilage were isolated. ASCs were cultured for at least three passages in vitro...
June 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30022616/daily-pain-measurements-and-retrospective-pain-measurements-in-hip-osteoarthritis-patients-with-intermittent-pain
#5
Carolien H Teirlinck, Dieke S Sonneveld, Sita M A Bierma-Zeinstra, Pim A J Luijsterburg
OBJECTIVE: To examine the value of daily pain measurements in hip osteoarthritis patients, and if the reliability of retrospective measurements was lower in patients with intermittent pain than in patients with a more constant pain. METHODS: We used data from a randomised controlled trial that investigated the effectiveness of general practitioner care plus exercise therapy in 203 patients with hip osteoarthritis. During the first 6 weeks, patients scored their pain each day...
July 19, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/30022370/serum-soluble-folate-receptor-%C3%AE-as-a-biomarker-for-the-activity-of-rheumatoid-arthritis-synovitis-and-the-response-to-anti-tnf-agents
#6
Hideo Otsubo, Yasuhiro Tsuneyoshi, Tadashi Nakamura, Takemasa Matsuda, Setsuro Komiya, Takami Matsuyama
This study aims to develop a sandwich ELISA system for the measurement of soluble folate receptor β (sFRβ) and evaluate whether base line levels of serum sFRβ are a biomarker for the activity of RA synovitis and the response to anti-TNF agents. Serum sFRβ from normal controls (41 samples), patients with OA (29 samples), and patients with RA (27 samples) and synovial fluid sFRβ from patients with RA (17 samples) were measured by sandwich ELISA, using anti-FRαβ and anti-FRβ antibodies as capture and detection antibodies, respectively...
July 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30022244/the-effects-of-inpatient-versus-outpatient-spa-therapy-on-pain-anxiety-and-quality-of-life-in-elderly-patients-with-generalized-osteoarthritis-a-pilot-study
#7
Kağan Özkuk, Bilal Uysal, Zeynep Ateş, Burcu Metin Ökmen, Refia Sezer, Gamze Dilek
This study aimed to investigate the effect of inpatient vs outpatient spa therapy on pain, quality of life, and anxiety in elderly patients with generalized osteoarthritis. A total of 150 patients were randomized into three groups. Group I was given medical treatment, group II was treated as outpatients, and group III was treated as inpatient spa therapy. Assessments were made using the Pain (VAS), EQ-5D-3L Scale, and State and Trait Anxiety Inventory (STAI) at the beginning of treatment (W0), at the end of treatment (W2), and at the fourth week after treatment (W6)...
July 18, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/30022227/spatial-distribution-of-microcracks-in-osteoarthritic-femoral-neck-influence-of-osteophytes-on-microcrack-formation
#8
Gustavo D Rabelo, Nathalie Portero-Muzy, Evelyne Gineyts, Jean-Paul Roux, Roland Chapurlat, Pascale Chavassieux
Osteophytes have been suggested to influence the bone mechanical properties. The aim of this study was to compare the microcrack density in osteophytes with that in the other parts of the osteoarthritic femoral neck (FN). The presence of microcracks was investigated in the ultra-distal FN and in the osteophytes in samples obtained during hip arthroplasty in 24 postmenopausal women aged 67 ± 10 years. Furthermore, the 3D microarchitecture and the collagen crosslinks contents were assessed by high-resolution peripheral quantitative computed tomography and high-performance liquid chromatography, respectively...
July 18, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/30021646/a-protocol-for-a-multicentre-randomised-double-blind-placebo-controlled-trial-to-compare-the-effect-of-annual-infusions-of-zoledronic-acid-to-placebo-on-knee-structural-change-and-knee-pain-over-24-months-in-knee-osteoarthritis-patients-zap2
#9
Dawn Aitken, Laura L Laslett, Guoqi Cai, Catherine Hill, Lyn March, Anita E Wluka, Yuanyuan Wang, Leigh Blizzard, Flavia Cicuttini, Graeme Jones
BACKGROUND: Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and size of subchondral bone marrow lesions (BMLs) over 6 months in knee OA patients with significant knee pain and BMLs. A longer, larger study is required to assess whether decreases in BML size will translate to reductions in cartilage loss over time. We are currently conducting a multicentre, randomised, double-blind, placebo-controlled trial over 24 months that aims to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change (assessed using magnetic resonance imaging (MRI)) and knee pain in knee OA patients...
July 18, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30021642/outcomes-of-simultaneous-high-tibial-osteotomy-and-anterior-cruciate-ligament-reconstruction-in-anterior-cruciate-ligament-deficient-knee-with-osteoarthritis
#10
Cheng Jin, Eun-Kyoo Song, Quan-He Jin, Nam-Hun Lee, Jong-Keun Seon
BACKGROUND: We aimed to evaluate clinical and radiological results after simultaneous open-wedge high tibial osteotomy (HTO) and anterior cruciate ligament (ACL) reconstruction in patients with ACL deficiency combined with medial uni-compartmental osteoarthritis (OA) and varus deformity. METHODS: This retrospective study was performed using data collected from 2005 to 2011 on a total of 24 patients who were diagnosed with ACL injury and medial unicompartmental OA with varus deformity, and who subsequently underwent simultaneous open-wedge HTO and arthroscopic ACL reconstruction...
July 18, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30021639/different-reliability-of-instrumented-gait-analysis-between-patients-with-unilateral-hip-osteoarthritis-unilateral-hip-prosthesis-and-healthy-controls
#11
Roland Zügner, Roy Tranberg, Vera Lisovskaja, Johan Kärrholm
BACKGROUND: The gait pattern varies within the population and between patient groups with different musculoskeletal diseases. It also varies over time due to various reasons. Three-dimensional gait analysis (3DGA) is frequently used to measure these changes, but the precision of this methodology may vary. METHODS: We primarily aimed to study the repeatability of hip motion measurements in patients with unilateral osteoarthritis (OA), patients with unilateral total hip arthroplasty (THA) and healthy controls...
July 18, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30021588/a-randomised-controlled-trial-of-the-clinical-and-cost-effectiveness-of-ultrasound-guided-intra-articular-corticosteroid-and-local-anaesthetic-injections-the-hip-injection-trial-hit-protocol
#12
Zoe Paskins, Gemma Hughes, Helen Myers, Emily Hughes, Susie Hennings, Andrea Cherrington, Amy Evans, Melanie Holden, Kay Stevenson, Ajit Menon, Kieran Bromley, Philip Roberts, Alison Hall, George Peat, Clare Jinks, Raymond Oppong, Martyn Lewis, Nadine E Foster, Christian Mallen, Edward Roddy
BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with hip OA between those receiving an ultrasound-guided intra-articular hip injection of corticosteroid with 1% lidocaine hydrochloride plus best current treatment with those receiving best current treatment alone. Secondary objectives are to determine specified comparative clinical and cost-effectiveness outcomes, and to explore, in a linked qualitative study, the lived experiences of patients with hip OA and experiences and impact of, ultrasound-guided intra-articular hip injection...
July 18, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30021584/footwear-for-self-managing-knee-osteoarthritis-symptoms-protocol-for-the-footstep-randomised-controlled-trial
#13
Kade L Paterson, Kim L Bennell, Tim V Wrigley, Ben R Metcalf, Penny K Campbell, Jessica Kazsa, Rana S Hinman
BACKGROUND: Knee osteoarthritis (OA) is a leading cause of musculoskeletal pain and disability globally, and abnormal knee loading is central to disease pathogenesis. Clinical guidelines recommend clinicians provide advice regarding appropriate footwear for people with knee OA, yet there is little research comparing the effects of different footwear on knee OA symptoms. Research suggests that wearing flat flexible shoes is associated with lower knee joint loads compared to stable supportive shoe styles...
July 18, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30021578/facilitating-physical-activity-and-reducing-symptoms-in-patients-with-knee-osteoarthritis-study-protocol-of-a-randomized-controlled-trial-to-test-a-theory-based-prevop-psychological-adherence-program-prevop-pap
#14
Nina Knoll, Diana Hilda Hohl, Susannah Motter, Jan Keller, Daniela Lange, Dieter Felsenberg, Peter Martus, Wolfgang Ertel, Ralf Schwarzer
BACKGROUND: The present randomized controlled trial, which is crossed with the "PREVenting the impairment of primary Osteoarthritis by high impact long-term Physical exercise regimen" Main Medical Trial (PrevOP-MMT), aims to evaluate a psychological adherence program (PrevOP-PAP), and is designed to support persons with knee osteoarthritis (OAK) in the uptake and maintenance of regular physical activity to reduce OAK symptoms. The PrevOP-PAP is based on the Health Action Process Approach (HAPA), a social-cognitive theory predicting health behavior change in individuals, extended here by social network characteristics and social exchange processes...
July 18, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30021552/the-effectiveness-of-inpatient-rehabilitation-after-uncomplicated-total-hip-arthroplasty-a-propensity-score-matched-cohort
#15
Justine M Naylor, Andrew Hart, Rajat Mittal, Ian A Harris, Wei Xuan
BACKGROUND: Inpatient rehabilitation is an expensive option following total hip arthroplasty (THA). We aimed to determine if THA patients who receive inpatient rehabilitation report better hip and quality of life scores post-surgery compared to those discharged directly home. METHODS: Prospective, propensity score matched cohort involving 12 private hospitals across five Australian States. Patients undergoing THA secondary to osteoarthritis were included. Those receiving inpatient rehabilitation for reasons other than choice or who experienced significant health events within 90-days post-surgery were excluded...
July 18, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30021388/microrna-449a-upregulation-promotes-chondrocyte-extracellular-matrix-degradation-in-osteoarthritis
#16
Jianjun Wu, Min Zou, Ansong Ping, Zhouming Deng, Lin Cai
Osteoarthritis (OA) is a highly prevalent chronic and degenerative joint disease characterized by the continuous destruction of the articular cartilage. MicroRNAs (miRNAs) have been reported to be strongly involved in the pathogenesis of OA. The aim of this study was to explore whether miR-449a regulates the expression of growth differentiation factor5 (GDF5), which promotes chondrocyte extracellular matrix (ECM) degradation. We found that miR-449a expression was upregulated in OA cartilage compared to that in normal cartilage...
September 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30021183/the-history-symptoms-causes-risk-factors-types-diagnosis-treatments-and-prevention-of-gout-part-1
#17
LaVonn Williams
Gout, a common and complex form of inflammatory arthritis, is characterized by abnormally elevated levels of uric acid in the blood. It is estimated that 52.5 million people in the U.S. have arthritis or one of the rheumatic diseases, according to the Centers for Disease Control and Prevention. There are over 100 rheumatic diseases and conditions. In the U.S., the most common types of arthritis or rheumatic diseases are osteoarthritis, gout, fibromyalgia, and rheumatoid arthritis, in that order according to prevalence...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021073/no-difference-in-the-koos-quality-of-life-subscore-between-anatomic-double-bundle-and-anatomic-single-bundle-anterior-cruciate-ligament-reconstruction-of-the-knee-a-prospective-randomized-controlled-trial-with-2-years-follow-up
#18
Cathrine Aga, May Arna Risberg, Morten Wang Fagerland, Steinar Johansen, Ingrid Trøan, Stig Heir, Lars Engebretsen
BACKGROUND: The double-bundle reconstruction technique was developed to resemble the properties of the native anterior cruciate ligament (ACL) more closely than the conventional single-bundle technique. The clinical benefit of the operative procedure is controversial, and there is a need for studies with a focus on patient-reported outcomes (PROs). STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. HYPOTHESIS: Anatomic double-bundle ACL reconstruction would be superior to anatomic single-bundle reconstruction regarding the change in the Knee injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QoL) subscore from baseline to 2-year follow-up...
July 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/30020816/advances-in-stem-cell-therapy-for-cartilage-regeneration-in-osteoarthritis
#19
Leire Iturriaga, Raquel Hernáez-Moya, Itsasne Erezuma, Alireza Dolatshahi-Piouz, Gorka Orive
Osteoarthritis (OA) is a progressive joint disease that compromises the structural integrity of cartilage tissue. Conventional treatments based on medication or surgery are nowadays inefficient and cell-based therapy has emerged as one of the most promising methods for cartilage regeneration. The first therapy developed for cartilage defects was Autologous Chondrocyte Implantation (ACI), but in the last few decades stem cells (SCs) from different sources have been proposed as a possible alternative for OA. Areas Covered: Stem cells sources and available delivery procedures (scaffolds/hydrogels) are presented, along with the main issues arisen in this regard...
July 18, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/30020152/classifications-in-brief-t%C3%A3-nnis-classification-of-hip-osteoarthritis
#20
Boris Kovalenko, Prashoban Bremjit, Navin Fernando
No abstract text is available yet for this article.
August 2018: Clinical Orthopaedics and related Research
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