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https://www.readbyqxmd.com/read/28535552/stem-cell-therapy-for-chronic-pain-management-review-of-uses-advances-and-adverse-effects
#1
Krishnan Chakravarthy, Yian Chen, Cathy He, Paul J Christo
BACKGROUND: This review article outlines the recent advances, uses, and adverse effects of cell-based therapy for chronic pain management. Cell based therapies are gaining increasing ground as novel treatment modalities for a variety of pain pathologies that include, but are not limited to, neuropathic pain and degenerative disc disease. As these treatment modalities become more common practice, we have focused our review to provide pain practitioners and other practicing physicians an understanding of the technology and to summarize key clinical data and existing clinical trials that are being pursued by clinical investigators worldwide...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535547/the-effectiveness-of-manual-therapy-for-relieving-pain-stiffness-and-dysfunction-in-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#2
Qinguang Xu, Bei Chen, Yueyi Wang, Xuezong Wang, Dapeng Han, Daofang Ding, Yuxin Zheng, Yuelong Cao, Hongsheng Zhan, Yao Zhou
BACKGROUND: Knee osteoarthritis (KOA) is the most common form of arthritis, leading to pain disability in seniors and increased health care utilization. Manual therapy is one widely used physical treatment for KOA. OBJECTIVE: To evaluate the effectiveness and adverse events (AEs) of manual therapy compared to other treatments for relieving pain, stiffness, and physical dysfunction in patients with KOA. STUDY DESIGN: A systematic review and meta-analysis of manual therapy for KOA...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535500/transient-receptor-potential-vanilloid-5-mediates-ca2-influx-and-inhibits-chondrocyte-autophagy-in-a-rat-osteoarthritis-model
#3
Yingliang Wei, Yanfang Wang, Yutong Wang, Lunhao Bai
BACKGROUND: Autophagy, a self-protective mechanism of chondrocytes, has become a promising target to impede the progress of osteoarthritis (OA). Autophagy is regulated by cytosolic Ca2+ activity and may thus be modified by the Ca2+ permeable transient receptor potential channel vanilloid 5 (TRPV5). Therefore, we investigated the potential role of TRPV5 in mediating Ca2+ influx and in inhibiting chondrocyte autophagy in a rat OA model. METHODS: The rat OA model was assessed by macroscopic and histological analyses...
May 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28535076/intraarticular-injection-of-a-cross-linked-sodium-hyaluronate-combined-with-triamcinolone-hexacetonide-cingal-to-provide-symptomatic-relief-of-osteoarthritis-of-the-knee-a-randomized-double-blind-placebo-controlled-multicenter-clinical-trial
#4
Laszlo Hangody, Robert Szody, Piotr Lukasik, Wojciech Zgadzaj, Endre Lénárt, Eva Dokoupilova, Daniela Bichovsk, Agnes Berta, Gabor Vasarhelyi, Andrea Ficzere, György Hangody, Gary Stevens, Miklos Szendroi
OBJECTIVE: To evaluate the efficacy and safety of an intraarticular injection of Cingal (Anika Therapeutics, Inc., Bedford, MA) compared with Monovisc (Anika Therapeutics, Inc., Bedford, MA) or saline for the treatment of knee osteoarthritis. DESIGN: This multicenter, double-blind, saline-controlled clinical trial randomized subjects with knee osteoarthritis (Kellgren-Lawrence grades I-III) to a single injection of Cingal (4 mL, 88 mg hyaluronic acid [HA] plus 18 mg triamcinolone hexacetonide [TH]), Monovisc (4 mL, 88 mg HA), or saline (4 mL, 0...
May 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28534758/engineering-tissues-to-heal-themselves-bioinks-and-tendon-scaffolds-show-promise-for-helping-the-body-recover-from-musculoskeletal-injury
#5
Sarah Campbell
Sufferers of osteoarthritis are all too aware of the daily pain and impairment of swollen joints, of having to give up sports-and jobs-due to cartilage defects. What they may be less aware of is that three-dimensional (3-D) bioprinting and bioink technologies are being developed to revolutionize the existing (and often imperfect) treatments available to them.
May 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28533697/a-comparison-of-predictors-and-intensity-of-acute-postsurgical-pain-in-patients-undergoing-total-hip-and-knee-arthroplasty
#6
Patrícia R Pinto, Teresa McIntyre, Vera Araújo-Soares, Patrício Costa, Ramón Ferrero, Armando Almeida
BACKGROUND: Acute pain is an expected result after surgery. Nevertheless, when not appropriately controlled, acute pain has a very negative impact on individual clinical outcomes, impairing healing and recovery, and has clear consequences on health care system costs. Augmenting knowledge on predictors and potentially modifiable determinants of acute postsurgical pain can facilitate early identification of and intervention in patients at risk. However, only a few studies have examined and compared acute pain after total hip arthroplasty (THA) and total knee arthroplasty (TKA)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28533611/the-effect-of-horse-riding-simulator-exercise-on-the-gait-muscle-strength-and-muscle-activation-in-elderly-people-with-knee-osteoarthritis
#7
Seung-Kyu Kim, Seong-Gil Kim, Gak HwangBo
[Purpose] The aim of this study was to examine the effects of horse-riding simulator exercise on gait ability and muscle strength, muscle activation in elderly with knee osteoarthritis. [Subjects and Methods] Thirty elderly patients with knee osteoarthritis were recruited, a horse-riding simulator group consisted of fifteen subjects and they performed exercise three times a week for eight weeks. And each exercise was performed, horse riding simulator exercise for 15 minutes and knee strengthening exercise for 15 minutes...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533596/the-ratio-of-medial-and-lateral-hamstring-muscle-thickness-does-not-correlate-with-the-lateral-tibial-rotation-angle-in-the-standing-position-in-healthy-young-adults
#8
Dong-Soo Lee, Sung-Dae Choung, Seung-Won Lee, Hye Rim Suh, Jae-Hoon Shim
[Purpose] To investigate the relationship between the lateral tibial rotation angle during knee joint flexion and the medial and lateral hamstring muscle thickness ratio during knee joint extension while resting, doing nothing, in upright standing position. The lateral tibial torsion is an important factor of orthopedic knee joint diseases as well as other weight bearing joint diseases such as osteoarthritis, meniscus syndrome, anterior cruciate ligament rupture, etc. [Subjects and Methods] Thirty healthy young adults participated in this study...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533592/articular-chondrocyte-alignment-in-the-rat-after-surgically-induced-osteoarthritis
#9
Hideaki Takahashi, Hiroyuki Tamaki, Noriaki Yamamoto, Hideaki Onishi
[Purpose] Chondrocytes in articular cartilage are aligned as columns from the joint surface. Notably, loss of chondrocyte and abnormalities of differentiation factors give rise to osteoarthritis (OA). However, the relationship between chondrocyte alignment and OA progression remains unclear. This study was performed to investigate temporal alterations in surgically-induced OA rats. [Subjects and Methods] Thirteen-week-old Wistar rats (n=30) underwent destabilized medial meniscus surgery in their right knee and sham surgery in their left knee...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533591/long-term-histopathological-developments-in-knee-joint-components-in-a-rat-model-of-osteoarthritis-induced-by-monosodium-iodoacetate
#10
Ikufumi Takahashi, Taro Matsuzaki, Masahiro Hoso
[Purpose] This study was performed to evaluate the long-term histopathological changes in knee-joint components including synovial membrane and joint capsule in a rat model of osteoarthritis (OA) induced by monosodium iodoacetate (MIA). [Subjects and Methods] Fifty male rats were used. OA was induced through intra-articular injection of MIA, and ten rats were randomly allocated to each of five groups induced with OA for 1, 2, 4, 6, or 8 weeks. At the end of each period, the knee components were examined histopathologically...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533290/pharmaceutical-grade-chondroitin-sulfate-is-as-effective-as-celecoxib-and-superior-to-placebo-in-symptomatic-knee-osteoarthritis-the-chondroitin-versus-celecoxib-versus-placebo-trial-concept
#11
Jean-Yves Reginster, Jean Dudler, Tomasz Blicharski, Karel Pavelka
OBJECTIVES: Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. METHODS: A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing changes in pain on a Visual Analogue Scale (VAS) and in the Lequesne Index (LI) as coprimary endpoints. Minimal-Clinically Important Improvement (MCII), Patient-Acceptable Symptoms State (PASS) were used as secondary endpoints...
May 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28532997/the-influence-of-varus-and-valgus-deviation-on-patellar-kinematics-in-healthy-knees-an-exploratory-cadaver-study
#12
Michael Worlicek, Benedikt Moser, Günther Maderbacher, Raphael Zentner, Florian Zeman, Joachim Grifka, Armin Keshmiri
BACKGROUND: Patellofemoral instability may lead to osteoarthritis, anterior knee pain, and patellar luxation. The purpose of this study was to conduct an exploratory investigation into the difference of patellar kinematics of healthy knees during extension/flexion cycles in neutral, varus and valgus alignment. METHODS: The three-dimensional patellar kinematics of 10 lower extremities of whole body cadavers were examined during passive motion, in neutral position, and under valgus and varus stress...
May 19, 2017: Knee
https://www.readbyqxmd.com/read/28532890/fascial-manipulation-%C3%A2-for-persistent-knee-pain-following-acl-and-meniscus-repair
#13
Sannasi Rajasekar, Aurélie Marie Marchand
Fascial Manipulation(®) (FM) is a manual therapy approach for the treatment of musculoskeletal pain. Anomalous fascial tension is common following surgery due to surgical scar, inadequate mobility and fear of movement. Fascial tension may result in pain and loss of mobility. This case report aims at investigating the effectiveness of FM(®) on pain and function in a patient following knee surgery. A 32 years old male patient, with persisting knee pain following anterior cruciate ligament reconstruction (hamstring graft) and meniscal repair, underwent the systematic FM(®) assessment process, the selected centers of coordination of myofascial units were treated...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28532870/effects-of-medical-exercise-therapy-in-patients-with-hip-osteoarthritis-a-randomized-controlled-trial-with-six-months-follow-up-a-pilot-study
#14
Håvard Østerås, Fredrik Paulsberg, Stian Endré Olsen, Berit Østerås, Tom Arild Torstensen
BACKGROUND & AIMS: There is no consensus regarding what type of exercises, combination of exercises or exercise dosage is most effective in patients with long-term hip arthrosis. The goal of this study was to evaluate the effects of two different exercise programs related to dose-response relationships. METHOD: Prospective randomized controlled clinical trial with 6 months follow where 33 participants were randomly assigned to either high repetitive, high dosage medical exercise therapy (MET) (n = 16) or low dosage exercise therapy (ET) (n = 17)...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28532493/distal-femoral-replacement-with-the-mml-system-a-single-center-experience-with-an-average-follow-up-of-86%C3%A2-months
#15
Andreas Toepfer, Norbert Harrasser, Paul-Ruben Schwarz, Florian Pohlig, Ulrich Lenze, Heinrich M L Mühlhofer, Ludger Gerdesmeyer, Ruediger von Eisenhart-Rothe, Christian Suren
BACKGROUND: The aim of this study was to compare the functional outcomes and complication rates after distal femoral replacement (DFR) performed with the modular Munich-Luebeck (MML) modular prosthesis (ESKA/Orthodynamics, Luebeck, Germany) in patients being treated for malignant disease or failed total knee arthroplasty. METHODS: A retrospective review of patient charts and a functional investigation (involving Musculoskeletal Tumor Society Score [MSTS], American Knee Society Score [AKSS], Oxford Knee Score [OKS], Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC], Toronto Extremity Salvage Score [TESS], the 12-Item Short-Form [SF-12] Health Survey, and a failure classification system developed by Henderson et al...
May 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28532445/cross-cultural-adaptation-and-validation-of-the-spanish-version-of-the-oxford-hip-score-in-patients-with-hip-osteoarthritis
#16
Jesús Martín-Fernández, Pedro Gray-Laymón, Antonio Molina-Siguero, Javier Martínez-Martín, Roberto García-Maroto, Isidoro García-Sánchez, Lidia García-Pérez, Vanesa Ramos-García, Olga Castro-Casas, Amaia Bilbao
BACKGROUND: Osteoarthritis (OA) of the hip is a disease that entails a major burden for patients and the society as a whole. One way of measuring this burden for the patient is through impact on Health-related Quality of Life (HRQL). The Oxford Hip Score (OHS) is a well-known tool to measure HRQL in patients with OA of the hip. This study aims to assess the psychometric properties of the Spanish-adapted version of the OHS, including its reliability, validity, and sensitivity to change...
May 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28531381/corrigendum-to-synovial-volume-vs-synovial-measurements-from-dynamic-contrast-enhanced-mri-as-measures-of-response-in-osteoarthritis-osteoarthritis-cartilage-24-2016-1392-1398
#17
A D Gait, R Hodgson, M J Parkes, C E Hutchinson, T W O'Neill, N Maricar, E J Marjanovic, T F Cootes, D T Felson
No abstract text is available yet for this article.
May 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28530520/cardiovascular-disease-and-gout-real-world-experience-evaluating-patient-characteristics-treatment-patterns-and-health-care-utilization
#18
Michael H Pillinger, Sripal Bangalore, Alyssa B Klein, Scott Baumgartner, Robert Morlock
BACKGROUND: Gout, hyperuricemia, and cardiovascular disease (CVD) are prevalent conditions in the United States, and while they share common risk factors such as obesity, hypertension, hypercholesterolemia, and type 2 diabetes mellitus, relatively little is known about what patient and disease characteristics may link CVD with hyperuricemia and gout and how the presence of both diseases affects management decisions differently than for patients with gout alone. OBJECTIVE: To identify differences in patient characteristics, patterns of urate-lowering therapy (ULT) use, and gout control in gout patients with and without cardiovascular comorbidity...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28530065/-the-relationship-between-overweight-obesity-and-knee-osteoarthritis
#19
REVIEW
Tal Frenkel Rutenberg, Michael Drexler
The prevalence of overweight and obesity in the western world is growing, and with it there is a growing number of patients with osteoarthritis, a condition that leads to pain and disability. The association between body weight and osteoarthritis is mediated by both mechanical and humeral factors such as growth factors, hormones and mediators of the immune system. This review will present the mechanisms which lead to osteoarthritis, and will discuss available treatments which are suitable for the overweight and obese population, along with promising emerging new treatments...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28530031/celecoxib-for-osteoarthritis
#20
REVIEW
Livia Puljak, Ana Marin, Davorka Vrdoljak, Filipa Markotic, Ana Utrobicic, Peter Tugwell
BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. It is often associated with major disability and impaired quality of life. There is currently no consensus on the best treatment to improve OA symptoms. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID). OBJECTIVES: To assess the clinical benefits (pain, function, quality of life) and safety (withdrawals due to adverse effects, serious adverse effects, overall discontinuation rates) of celecoxib in osteoarthritis (OA)...
May 22, 2017: Cochrane Database of Systematic Reviews
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