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https://www.readbyqxmd.com/read/28937501/patients-less-likely-to-lose-weight-following-a-knee-replacement-results-from-the-osteoarthritis-initiative
#1
Christine A Pellegrini, Jing Song, Pamela A Semanik, Rowland W Chang, Jungwha Lee, Abigail L Gilbert, Daniel Pinto, Linda Ehrlich-Jones, Dorothy D Dunlop
BACKGROUND: Knee replacement typically results in reduced pain and improved function, but it is unclear if these improvements lead to weight loss. OBJECTIVE: The purpose of this study was to examine weight change patterns preoperatively and postoperatively among overweight/obese knee replacement patients. METHODS: The study evaluated 210 overweight/obese patients from the Osteoarthritis Initiative who underwent a knee replacement during an 8-year longitudinal study...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937470/patients-less-likely-to-lose-weight-following-a-knee-replacement-results-from-the-osteoarthritis-initiative
#2
Christine A Pellegrini, Jing Song, Pamela A Semanik, Rowland W Chang, Jungwha Lee, Abigail L Gilbert, Daniel Pinto, Linda Ehrlich-Jones, Dorothy D Dunlop
BACKGROUND: Knee replacement typically results in reduced pain and improved function, but it is unclear if these improvements lead to weight loss. OBJECTIVE: The purpose of this study was to examine weight change patterns preoperatively and postoperatively among overweight/obese knee replacement patients. METHODS: The study evaluated 210 overweight/obese patients from the Osteoarthritis Initiative who underwent a knee replacement during an 8-year longitudinal study...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937277/injectable-viscoelastic-supplements-a-review-for-radiologists
#3
Dermot J Bowden, Caoimhe A Byrne, Abdullah Alkhayat, Stephen J Eustace, Eoin C Kavanagh
OBJECTIVE: Hyaluronic acid (HA) is increasingly used by musculoskeletal radiologists in the treatment of osteoarthritis (OA). Although the evidence base for its efficacy is controversial, it remains in common use. With initial evidence suggesting its efficacy in the knee, it is now offered for treating OA of the hip, ankle, and elsewhere. CONCLUSION: HA is available in a wide variety of preparations, which may vary in concentration and chemical composition. Clinicians offering intraarticular HA injection should be familiar with the common preparations available and the principal differences between them, its mechanism of action, and the profile of adverse effects associated with its use...
October 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28935982/glycogen-synthase-kinase-3%C3%AE-inhibition-links-mitochondrial-dysfunction-extracellular-matrix-remodelling-and-terminal-differentiation-in-chondrocytes
#4
S Guidotti, M Minguzzi, D Platano, S Santi, G Trisolino, G Filardo, E Mariani, R M Borzì
Following inflammatory stimuli, GSK3 inhibition functions as a hub with pleiotropic effects leading to cartilage degradation. However, little is known about the effects triggered by its direct inhibition as well as the effects on mitochondrial pathology, that contributes to osteoarthritis pathogenesis. To this aim we assessed the molecular mechanisms triggered by GSK3β inactivating stimuli on 3-D (micromass) cultures of human articular chondrocytes. Stimuli were delivered either at micromass seeding (long term) or after maturation (short term) to explore "late" effects on terminal differentiation or "early" mitochondrial effects, respectively...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935435/subchondral-tibial-bone-texture-predicts-the-incidence-of-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#5
T Janvier, R Jennane, H Toumi, E Lespessailles
OBJECTIVES: To evaluate whether trabecular bone texture (TBT) parameters measured on computed radiographs could predict the onset of radiographic knee osteoarthritis (OA). MATERIALS AND METHODS: Subjects from the Osteoarthritis Initiative with no sign of radiographic OA at baseline were included. Cases that developed either a global radiographic OA defined by the Kellgren-Lawrence (KL) scale, a joint space narrowing (JSN) or tibial osteophytes (TOS) were compared with the controls with no changes after 48 months of follow-up...
September 18, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28934966/effectiveness-of-an-interactive-telerehabilitation-system-with-home-based-exercise-training-in-patients-after-total-hip-or-knee-replacement-study-protocol-for-a-multicenter-superiority-no-blinded-randomized-controlled-trial
#6
Sarah Eichler, Sophie Rabe, Annett Salzwedel, Steffen Müller, Josefine Stoll, Nina Tilgner, Michael John, Karl Wegscheider, Frank Mayer, Heinz Völler
BACKGROUND: Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain...
September 21, 2017: Trials
https://www.readbyqxmd.com/read/28934945/aqua-walking-as-an-alternative-exercise-modality-during-cardiac-rehabilitation-for-coronary-artery-disease-in-older-patients-with-lower-extremity-osteoarthritis
#7
Jong-Young Lee, Kee-Chan Joo, Peter H Brubaker
BACKGROUND: The purpose of this study was to examine the effects of aqua walking (AW) on coronary artery disease (CAD) and cardiorespiratory fitness in older adults with osteoarthritis in the lower extremity and compare it with that of traditional over-ground walking. METHODS: Sixty consecutive eligible patients who had undergone percutaneous coronary intervention for CAD with limited ambulation due to lower extremity osteoarthritis were recruited. They were randomly assigned to the AW program group, treadmill/track walking (TW) program group, or non-exercise control group (CON)...
September 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28934878/surgical-preparation-for-articular-cartilage-regeneration-in-the-osteoarthritic-knee-joint
#8
Joerg Mika, Thomas O Clanton, Catherine G Ambrose, Raimund W Kinne
PURPOSE: Autologous chondrocyte implantation (ACI) is a treatment option even in early osteoarthritis (OA). Surgical preparation for ACI should avoid penetration of the subchondral bone plate to prevent hemorrhage, fibrin clot formation, and subsequent activation of the inflammatory response. HYPOTHESIS: Current surgical procedures with ring curettes preserve the integrity of the subchondral bone plate, even in patients with OA. METHODS: Subchondral femoral bone plates ( n = 40) of OA knees undergoing total knee arthroplasty were prepared in vivo using standard, non-brute-force debridement for ACI...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934876/comparison-of-intra-articular-injection-of-hyaluronic-acid-and-n-acetyl-cysteine-in-the-treatment-of-knee-osteoarthritis-a-pilot-study
#9
Mustafa Ozcamdalli, Abdulhamit Misir, Turan Bilge Kizkapan, Erdal Uzun, Fuat Duygulu, Cevat Yazici, Ibrahim Halil Kafadar
Objective To compare the relative effectiveness of intra-articular N-acetyl cysteine (NAC) and hyaluronic acid (HA) on pain, function and cartilage degradation markers in patients with mild to moderate knee osteoarthritis (OA). Design We prospectively conducted a clinical trial with 20 patients having a diagnosis of Kellgren-Lawrence grade 2-3 knee OA, and randomly allocated to the HA or NAC groups. Groups were matched on age, sex, and body mass index. Injections of 3-mL HA (Hylan G-F 20) or 3-mL NAC (Asist ampoule) were administered as a single shot...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934868/the-auscan-and-prwhe-demonstrate-comparable-internal-consistency-and-validity-in-patients-with-early-thumb-carpometacarpal-osteoarthritis
#10
Thomas J McQuillan, Molly M Vora, Deborah E Kenney, Joseph J Crisco, Arnold-Peter C Weiss, Kerry A Ebert, Kathleen E Snelgrove, Alexandra Sarnowski, Amy L Ladd
BACKGROUND: The Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and Patient-Rated Wrist-Hand Evaluation (PRWHE) are 2 patient-related outcome measures to assess pain and disability in patients with osteoarthritis (OA). The purpose of this study was to evaluate the AUSCAN and PRWHE in a large-scale, longitudinal cohort of patients with early thumb carpometacarpal (CMC) OA. METHODS: We obtained baseline data on 135 individuals (92 with early CMC OA participants and 43 asymptomatic controls) and at follow-up (year 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28934866/initial-experience-with-synthetic-mri-of-the-knee-at-3t-comparison-with-conventional-t-1-weighted-imaging-and-t2-mapping
#11
Sunghoon Park, Kyu-Sung Kwack, Young Ju Lee, Sung-Min Gho, Hyun Young Lee
OBJECTIVE: To assess the feasibility and accuracy of synthetic magnetic resonance imaging (MRI) compared to conventional T1-weighted and multi-echo spin-echo (MESE) sequences for obtaining T2 values in the knee joint at 3 Tesla. METHODS: This retrospective study included 19 patients with normal findings in the knee joint who underwent both synthetic MRI and MESE pulse sequences for T2 quantification. T2 values of the two sequences at the articular cartilage, bone marrow, and muscle were measured...
September 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28934732/long-noncoding-rna-cir-promotes-chondrocyte-extracellular-matrix-degradation-in-osteoarthritis-by-acting-as-a-sponge-for-mir-27b
#12
Yu-Fei Li, Shu-Hua Li, Yong Liu, Ya-Tong Luo
BACKGROUND/AIMS: Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation. The degradation of the extracellular matrix (ECM) of chondrocyte is closely associated with the destruction of joints in OA patients. lncRNAs are non-coding segments of RNA that possess important regulatory functions at the cellular level and in a variety of pathophysiological processes. The present study was conducted to investigate whether lncRNA-CIR regulated the expression of MMP13 as a sponge of miR-27 in OA...
September 21, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28934632/in-vivo-biomechanical-behavior-of-the-trapeziometacarpal-joint-in-healthy-and-osteoarthritic-subjects
#13
Priscilla D'Agostino, Benjamin Dourthe, Faes Kerkhof, G Harry Van Lenthe, Filip Stockmans, Evie E Vereecke
BACKGROUND: The contact biomechanics of the trapeziometacarpal joint have been investigated in several studies. However, these led to conflicting results and were mostly performed in vitro. The purpose of this study was to provide further insight on the contact biomechanics of the trapeziometacarpal joint by in vivo assessment of healthy and osteoarthritic subjects. METHODS: The hands of 16 healthy women and 6 women with trapeziometacarpal osteoarthritis were scanned in positions of maximal thumb extension, flexion, abduction and adduction during three isometric tasks (lateral key pinch, power grasp and jar twist) and in thumb rest posture (relaxed neutral)...
September 12, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28934544/conjoint-tendon-release-in-direct-anterior-total-hip-arthroplasty-no-impact-on-patient-outcomes
#14
Reina Yao, James L Howard, Brent A Lanting
The direct anterior (DA) approach for total hip arthroplasty (THA) has become increasingly popular. However, femoral access can be more technically challenging in difficult cases as compared with other approaches. Conjoint tendon release can improve proximal femoral exposure, but its effect on patient function and pain has not been studied. This study evaluated the effect of conjoint tendon release on length of stay (LOS), inpatient pain medication requirements, and functional outcomes of patients undergoing DA THA...
September 21, 2017: Orthopedics
https://www.readbyqxmd.com/read/28934396/evaluation-of-shared-genetic-aetiology-between-osteoarthritis-and-bone-mineral-density-identifies-smad3-as-a-novel-osteoarthritis-risk-locus
#15
Sophie Hackinger, Katerina Trajanoska, Unnur Styrkarsdottir, Eleni Zengini, Julia Steinberg, Graham R S Ritchie, Konstantinos Hatzikotoulas, Arthur Gilly, Evangelos Evangelou, John P Kemp, David Evans, Thorvaldur Ingvarsson, Helgi Jonsson, Unnur Thorsteinsdottir, Kari Stefansson, Andrew W McCaskie, Roger A Brooks, Jeremy M Wilkinson, Fernando Rivadeneira, Eleftheria Zeggini
Osteoarthritis (OA) is a common complex disease with high public health burden and no curative therapy. High bone mineral density (BMD) is associated with an increased risk of developing OA, suggesting a shared underlying biology. Here, we performed the first systematic overlap analysis of OA and BMD on a genome wide scale. We used summary statistics from the GEFOS consortium for lumbar spine (n = 31,800) and femoral neck (n = 32,961) BMD, and from the arcOGEN consortium for three OA phenotypes (hip, ncases=3,498; knee, ncases=3,266; hip and/or knee, ncases=7,410; ncontrols=11,009)...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28933742/vitamin-d-supplementation-improves-quality-of-life-and-physical-performance-in-osteoarthritis-patients
#16
Pacharee Manoy, Pongsak Yuktanandana, Aree Tanavalee, Wilai Anomasiri, Srihatach Ngarmukos, Thanathep Tanpowpong, Sittisak Honsawek
(1) Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D₂ supplementation on muscle strength and physical performance in knee OA patients; (2) Methods: One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D₂ (ergocalciferol) per week for six months...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28933476/piceatannol-inhibits-the-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritic-chondrocytes-and-ameliorates-osteoarthritis-in-mice-by-activating-nrf2
#17
Qian Tang, Zhenhua Feng, Minji Tong, Jianxiang Xu, Gang Zheng, Liyan Shen, Ping Shang, Yu Zhang, Haixiao Liu
Osteoarthritis (OA) is a complex process, to which an inflammatory environment contributes markedly. Piceatannol exerts anti-inflammatory effects on several diseases. In the current study, we explored the protective effects of piceatannol on the progression of OA and investigated its molecular target. In vitro, piceatannol not only attenuated the over-production of inflammatory mediators and cytokines-such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)-but also suppressed the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) at both the mRNA and protein levels...
September 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28933330/-short-term-results-of-surgical-treatment-of-patients-with-hallux-rigidus
#18
M Dygrýnová, M Uvízl, J Gallo
PURPOSE OF THE STUDY Hallux rigidus is common and degenerative arthritis of the first metatarsophalangeal joint. The aim of this study was to assess the results of cheilectomy and total joint replacement (TJR) in patients with hallux rigidus. Minimum duration of followup was 18 months. MATERIAL AND METHODS The study included fifty-nine patients who underwent surgery at our Department due to hallux rigidus between January 2013 and December 2014. Thirty-seven patients underwent cheilectomy and twenty-two patients had total joint arthroplasty using METIS®...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28933328/-local-application-of-tranexamic-acid-in-total-hip-arthroplasty-decreases-blood-loss-and-consumption-of-blood-transfusion
#19
J Lošťák, J Gallo, M Večeřa, J Špička, K Langová
PURPOSE OF THE STUDY The primary aim of our study was to identify the effects of local application of tranexamic acid (TXA, Exacyl) on the amount of postoperative blood loss and blood transfusion requirement in primary total hip arthroplasty. We also recorded the levels of postoperative haemoglobin and its drop in early period after surgery. In each patient, we monitored in detail the incidence of early complications (haematoma, wound exudate). Lastly, the economic aspect of TXA administration was also taken into account...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28933139/from-art-to-science-the-functional-damage-due-to-thumb-osteoarthritis-finely-described-by-velazquez-300-years-before-its-clinical-description
#20
J H Villafañe, R Cantero-Tellez, S Negrini, P Berjano
Velazquez showed to know the entity of thumb osteoarthritis by finely describing it in one of his paintings. The concepts of anatomical damage, loss of strenght, and functional impairment are transmitted to the observer.
September 21, 2017: Reumatismo
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