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https://www.readbyqxmd.com/read/28101863/lessons-from-animal-models-of-cytoplasmic-intermediate-filament-proteins
#1
Jamal-Eddine Bouameur, Thomas M Magin
Cytoplasmic intermediate filaments (IFs) represent a major cytoskeletal network contributing to cell shape, adhesion and migration as well as to tissue resilience and renewal in numerous bilaterians, including mammals. The observation that IFs are dispensable in cultured mammalian cells, but cause tissue-specific, life-threatening disorders, has pushed the need to investigate their function in vivo. In keeping with human disease, the deletion or mutation of murine IF genes resulted in highly specific pathologies...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28101861/structural-transition-of-trichocyte-keratin-intermediate-filaments-during-development-in-the-hair-follicle
#2
R D Bruce Fraser, David A D Parry
The intermediate filaments (IF) in trichocyte (hard α-) keratin are unique amongst the various classes of IF in having not one but two topologically-distinct structures. The first is formed at an early stage of hair development in a reducing environment within the cells in the lower part of the follicle. The second structure occurs at a later stage of hair development in the upper part of the follicle, where there is a transition to an oxidizing environment. Crosslinking studies reveal that molecular slippage occurs within the IF upon oxidation and that this results in many cysteine residues lying in near axial alignment, thereby facilitating disulphide bond formation...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28101636/a-slow-opportunist-physiological-and-growth-responses-of-an-obligate-understory-plant-to-patch-cut-harvesting
#3
Jennifer L Chandler
Understory light environments change rapidly following timber harvest, and while many understory species utilize and benefit from the additional light, this response is not ubiquitous in shade-obligate species. I examined the effects of patch cut timber harvest on the physiology and growth of an obligate forest understory species to determine if disturbances via timber harvest are physiological stressors or whether such disturbances provide physiological benefits and growth increases in understory species. Forest canopy structure, along with photosynthesis, respiration, water use efficiency, stomatal conductance, and growth rates of American ginseng were quantified one summer before and two summers after patch cut timber harvest...
January 19, 2017: Oecologia
https://www.readbyqxmd.com/read/28100219/increased-amygdala-reactivity-following-early-life-stress-a-potential-resilience-enhancer-role
#4
Tetsuya Yamamoto, Shigeru Toki, Greg J Siegle, Masahiro Takamura, Yoshiyuki Takaishi, Shinpei Yoshimura, Go Okada, Tomoya Matsumoto, Takashi Nakao, Hiroyuki Muranaka, Yumiko Kaseda, Tsuneji Murakami, Yasumasa Okamoto, Shigeto Yamawaki
BACKGROUND: Amygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults...
January 18, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28100062/prevalence-and-correlates-of-psychological-distress-of-middle-aged-and-older-women-living-with-hiv
#5
Fabiana Monteiro, Maria Cristina Canavarro, Marco Pereira
The aims of this study were to examine the prevalence and correlates of psychological distress among older women living with HIV in comparison to their male counterparts and younger women and to identify the sociodemographic and disease-related factors associated with psychological distress. The sample consisted of 508 HIV-infected patients (65 older women, 323 women aged below 50 years, and 120 older men) recruited from 10 Portuguese hospitals. Data regarding psychological distress were collected using the Brief Symptom Inventory (BSI)...
January 19, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28100016/validation-of-an-enzyme-immunoassay-and-comparison-of-fecal-cortisol-metabolite-levels-in-black-and-gold-howler-monkeys-alouatta-caraya-inhabiting-fragmented-and-continuous-areas-of-the-humid-chaco-region-argentina
#6
Verónica Inés Cantarelli, Maria Amparo Perez-Rueda, Martin M Kowalewski, Gabriela F Mastromonaco, Marina Flavia Ponzio
In the last years, the study of how environmental stimuli influence the physiology and specifically the endocrinology of an organism became increasingly important, relying mainly on the quantification of glucocorticoids to monitor animal welfare. Most studies investigating cortisol levels in primates were focused on the impact of social stressors; however, a major concern for the conservation of howler monkeys is the increased habitat fragmentation led by the advancement of the agricultural frontier. We compared fecal cortisol metabolite levels (FGCM) in howler monkeys (Alouatta caraya) living in fragmented and continuous forests of the Argentine humid Chaco region, throughout the warm season (spring-summer)...
January 18, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28098783/the-influence-of-the-toxin-antitoxin-mazef-on-growth-and-survival-of-listeria-monocytogenes-under-stress
#7
Thomas D Curtis, Ippei Takeuchi, Lone Gram, Gitte M Knudsen
A major factor in the resilience of Listeria monocytogenes is the alternative sigma factor B (σ(B)). Type II Toxin/Antitoxin (TA) systems are also known to have a role in the bacterial stress response upon activation via the ClpP or Lon proteases. Directly upstream of the σ(B) operon in L. monocytogenes is the TA system mazEF, which can cleave mRNA at UACMU sites. In this study, we showed that the mazEF TA locus does not affect the level of persister formation during treatment with antibiotics in lethal doses, but exerts different effects according to the sub-inhibitory stress added...
January 13, 2017: Toxins
https://www.readbyqxmd.com/read/28098630/collapse-of-the-microbiome-emergence-of-the-pathobiome-and-the-immunopathology-of-sepsis
#8
John C Alverdy, Monika A Krezalek
The definition of sepsis has been recently modified to accommodate emerging knowledge in the field, while at the same time being recognized as challenging, if not impossible, to define. Here, we seek to clarify the current understanding of sepsis as one that has been typically framed as a disorder of inflammation to one in which the competing interests of the microbiota, pathobiota, and host immune cells lead to loss of resilience and nonresolving organ dysfunction. Here, we challenge the existence of the idea of noninfectious sepsis given that critically ill humans never exist in a germ-free state...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28098349/ectopic-expression-of-two-areb-abf-orthologs-increase-dehydration-tolerance-in-cotton-gossypium-hirsutum
#9
Tyson C C Kerr, Haggag Abdel-Mageed, Lorenzo Aleman, Joohyun Lee, Paxton Payton, Dakota Cryer, Randy D Allen
Plants have evolved complex molecular, cellular, and physiological mechanisms to respond to environmental stressors. Due to the inherent complexity of this response, genetic manipulation to substantially improve water deficit tolerance, particularly in agricultural crops, has been largely unsuccessful, as the improvements are frequently accompanied by slower growth and delayed reproduction. Here, we ectopically express two abiotic stress responsive bZIP AREB/ABF transcription factor orthologs, Arabidopsis ABF3 and a Gossypium hirsutum ABF2D, in G...
January 18, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28097993/exploring-how-mindfulness-and-self-compassion-can-enhance-compassionate-care
#10
Caroline Barratt
Research suggests that the development of mindfulness and self-compassion may help to improve the well-being and resilience of professionals and students in the healthcare setting. This is reflected in the growth of mindfulness training for these individuals. Mindfulness is an important aspect of self-compassion, and healthcare professionals should be aware of the need to care for themselves when caring for others. This article explores the concepts of mindfulness and self-compassion and their relationship with, and ability to enhance, compassionate care...
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28097493/service-users-perceptions-of-an-outreach-wellbeing-service-a-social-enterprise-for-promoting-mental-health
#11
Sandra Elaine Hartley
Inadequate provision and limited access to mental healthcare has been highlighted with the need to offer more contemporary ways to provide clinically effective interventions. This study aimed to present an insight into service users' perceptions of an outreach Wellbeing Service (WBS), providing psychological therapy in social settings. Descriptive and thematic analysis was undertaken of 50 returned surveys. Comparison of initial and final mental health measures demonstrated a significant improvement in all outcomes with 96% of participants reporting being helped by attending...
January 17, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28096897/the-impact-of-organisational-change-and-fiscal-restraint-on-organisational-culture
#12
Frances Dark, Harvey Whiteford, Neal M Ashkanasy, Carol Harvey, Meredith Harris, David Crompton, Ellie Newman
BACKGROUND: Strategies to implement evidence-based practice have highlighted the bidirectional relationship of organisational change on organisational culture. The present study examined changes in perceptions of organisational culture in two community mental health services implementing cognitive therapies into routine psychosis care over 3 years. During the time of the study there were a number of shared planned and unplanned changes that the mental health services had to accommodate...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28096409/field-scale-experiments-reveal-persistent-yield-gaps-in-low-input-and-organic-cropping-systems
#13
Alexandra N Kravchenko, Sieglinde S Snapp, G Philip Robertson
Knowledge of production-system performance is largely based on observations at the experimental plot scale. Although yield gaps between plot-scale and field-scale research are widely acknowledged, their extent and persistence have not been experimentally examined in a systematic manner. At a site in southwest Michigan, we conducted a 6-y experiment to test the accuracy with which plot-scale crop-yield results can inform field-scale conclusions. We compared conventional versus alternative, that is, reduced-input and biologically based-organic, management practices for a corn-soybean-wheat rotation in a randomized complete block-design experiment, using 27 commercial-size agricultural fields...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096124/nutritional-considerations-for-healthy-aging-and-reduction-in-age-related-chronic-disease
#14
REVIEW
Julie Shlisky, David E Bloom, Amy R Beaudreault, Katherine L Tucker, Heather H Keller, Yvonne Freund-Levi, Roger A Fielding, Feon W Cheng, Gordon L Jensen, Dayong Wu, Simin N Meydani
A projected doubling in the global population of people aged ≥60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, as adults age they become at risk of "nutritional frailty," which can compromise their ability to meet nutritional requirements at a time when specific nutrient needs may be high...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28096009/perceptions-of-dying-well-and-distressing-death-by-acute-care-nurses
#15
Christine A Becker, Greg Wright, Kristen Schmit
AIM: This study aims to identify perceptions of nurses practicing in four adult inpatient units regarding their actions to provide quality end of life care for dying patients, their definitions of dying well, and their symptoms of distress and actions they took for relief. BACKGROUND: Nurses caring for patients who are dying want them to have the best death possible; however, many nurses are not prepared for every death which may occur. METHODS: Qualitative questionnaire data were collected from 49 nurses on four adult inpatient nursing units to analyze nurse perceptions of distressing death and dying well...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28095933/understanding-older-adults-resilience-during-the-brisbane-floods-social-capital-life-experience-and-optimism
#16
Lauren Brockie, Evonne Miller
OBJECTIVE: The purpose of this study was to explore how social capital or the impact of life and previous disaster experience facilitated resilience in older adults who experienced the 2011 and 2013 floods in Brisbane, Australia. METHODS: Data were drawn from in-depth interviews of 10 older adults from Brisbane who were evacuated in both the 2011 and 2013 floods. A combined qualitative approach drawing from the methods of constructivist grounded theory and narrative inquiry was applied and the data were analyzed by using (inductive) line-by-line and axial coding...
January 18, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28095824/community-based-health-care-is-an-essential-component-of-a-resilient-health-system-evidence-from-ebola-outbreak-in-liberia
#17
Kendra Siekmans, Salim Sohani, Tamba Boima, Florence Koffa, Luay Basil, Saïd Laaziz
BACKGROUND: Trained community health workers (CHW) enhance access to essential primary health care services in contexts where the health system lacks capacity to adequately deliver them. In Liberia, the Ebola outbreak further disrupted health system function. The objective of this study is to examine the value of a community-based health system in ensuring continued treatment of child illnesses during the outbreak and the role that CHWs had in Ebola prevention activities. METHODS: A descriptive observational study design used mixed methods to collect data from CHWs (structured survey, n = 60; focus group discussions, n = 16), government health facility workers and project staff...
January 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28095808/associations-between-access-to-alcohol-outlets-and-alcohol-intake-and-depressive-symptoms-in-women-from-socioeconomically-disadvantaged-neighbourhoods-in-australia
#18
Karen E Lamb, Lukar E Thornton, Megan Teychenne, Catherine Milte, Ester Cerin, Kylie Ball
BACKGROUND: This study examined associations between alcohol outlet access and alcohol intake, depressive symptoms score and risk of depression among women residing in disadvantaged neighbourhoods in Victoria, Australia. METHODS: Data on depressive symptoms, alcohol intake and socio-demographic characteristics were obtained from a sample of 995 adult women from Victoria, Australia who were surveyed as part of the Resilience in Eating and Activity Despite Inequality (READI) study...
January 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28095209/psychological-factors-influence-the-overlap-syndrome-in-functional-gastrointestinal-disorders-fgids-among-middle-aged-women-in-south-korea
#19
Seung-Ho Jang, Han-Seung Ryu, Suck-Chei Choi, Hye-Jin Lee, Sang-Yeol Lee
This study investigated psychological factors related to the overlap syndrome i.e., multiple gastrointestinal conditions that are part of functional gastrointestinal disorders (FGID) in the same individual and potentially related to quality of life (QOL) among women aged 45-60 years (n = 627) in South Korea. The study was undertaken between July 2014 and March 2015. Depressive and anxiety symptoms were ascertained using the Center for Epidemiologic Studies Depression scale (CES-D) and Beck Anxiety Inventory (BAI), respectively...
January 17, 2017: Women & Health
https://www.readbyqxmd.com/read/28094510/nanoporous-gold-based-electrode-morphology-libraries-for-investigating-structure-property-relationships-in-nucleic-acid-based-electrochemical-biosensors
#20
Zimple Matharu, Pallavi Daggumati, Ling Wang, Tatiana S Dorofeeva, Zidong Li, Erkin Seker
Nanoporous gold (np-Au) electrode coatings significantly enhance performance of electrochemical nucleic acid biosensors due to their three-dimensional nanoscale network, high electrical conductivity, facile surface functionalization, and biocompatibility. Contrary to planar electrodes, the np-Au electrodes also exhibit sensitive detection in the presence of common biofouling media due to their porous structure. However, the pore size of the nano-matrix plays a critical role in dictating the extent of biomolecular capture and transport...
January 17, 2017: ACS Applied Materials & Interfaces
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