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https://www.readbyqxmd.com/read/29782833/insights-into-stabilizing-forces-in-amyloid-fibrils-of-differing-sizes-from-polarizable-molecular-dynamics-simulations
#1
Darcy S Davidson, Anne M Brown, Justin A Lemkul
Pathological aggregation of amyloid-forming proteins is a hallmark of a number of human diseases, including Alzheimer's, type 2 diabetes, Parkinson's, and more. Despite having very different primary amino acid sequences, these amyloid proteins form similar supramolecular, fibril structures that are highly resilient to physical and chemical denaturation. To better understand the structural stability of disease-related amyloids and to gain a greater understanding of factors that stabilize functional amyloid assemblies, insights into tertiary and quaternary interactions are needed...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29782373/compliance-and-high-reliability-in-a-complex-healthcare-organization
#2
Maxine dellaBadia Simon
When considering the impact of regulation on healthcare, visualize a spider's web. The spider weaves sections together to create the whole, with each fiber adding to the structure to support its success or lead to its failure. Each section is dependent on the others, and all must be aligned to maintain the structure. Outside forces can cause a shift in the web's fragile equilibrium.The interdependence of the sections of the spider's web is similar to the way hospital departments and services work together. An organization's structure must be shaped to support its mission and vision...
2018: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29781992/muscle-imbalances-testing-and-training-functional-eccentric-hamstring-strength-in-athletic-populations
#3
Petr Stastny, Michal Lehnert, James J Tufano
Many hamstring injuries that occur during physical activity occur while the muscles are lengthening, during eccentric hamstring muscle actions. Opposite of these eccentric hamstring actions are concentric quadriceps actions, where the larger and likely stronger quadriceps straighten the knee. Therefore, to stabilize the lower limbs during movement, the hamstrings must eccentrically combat against the strong knee-straightening torque of the quadriceps. As such, eccentric hamstring strength expressed relative to concentric quadricep strength is commonly referred to as the "functional ratio" as most movements in sports require simultaneous concentric knee extension and eccentric knee flexion...
May 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781969/an-ecological-approach-toward-prevention-and-care-of-victims-of-domestic-minor-sex-trafficking
#4
Rosario V Sanchez, Dula F Pacquiao
Sex trafficking is a widespread form of human trafficking that exists globally. The forced sexual exploitation of young women for profit at the hands of traffickers is a human rights violation. Sex trafficking is a form of modern-day slavery where youths are sold as a commodity. It is difficult to determine the wide range of negative health outcomes associated with domestic minor sex trafficking due to the hidden nature of the crime and its lack of statistical data to determine prevalence. Viewing domestic minor sex trafficking through an ecological lens assists in the understanding of the multiple complex interactions between victims, their relationships, and environments that influence their health...
April 2018: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/29781791/the-facilitators-and-challenges-of-dying-at-home-with-dementia-a-narrative-synthesis
#5
Caroline Mogan, Mari Lloyd-Williams, Karen Harrison Dening, Christopher Dowrick
BACKGROUND: It is reported that, given the right support, most people would prefer to die at home, yet a very small minority of people with dementia do so. At present, knowledge gaps remain on how best to support end-of-life care at home for people with dementia. AIM: To identify and understand the challenges and facilitators of providing end-of-life care at home for people with dementia. DESIGN: Narrative synthesis of qualitative and quantitative data...
June 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29781730/the-positive-side-of-effort-a-review-of-the-impact-of-motivation-and-engagement-on-neuropsychological-performance
#6
Benjamin D Hill, Stephen L Aita
Almost the entirety of research on effort in clinical neuropsychology has focused on negative aspects of effort in neuropsychological assessment, with most work over the last 20 years emphasizing feigned cognitive impairment. In contrast, few studies have explored trait-level positive influences on motivation and engagement in regard to neuropsychological testing. This paper reviews potential constructs associated with positive aspects of effort in neuropsychological testing, including conation, grit, Need for Cognition, and personality factors from the Five Factor Model of personality (Big Five)...
July 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29781729/positive-psychology-perspective-on-traumatic-brain-injury-recovery-and-rehabilitation
#7
Amanda R Rabinowitz, Peter A Arnett
Recovery from traumatic brain injury (TBI) is heterogeneous, with injury characteristics and neuropathological findings accounting for a relatively modest proportion of the variance in clinical outcome. Furthermore, premorbid personality traits and psychological characteristics may moderate psychosocial recovery. Constructs from the field of positive psychology have been examined in multiple illness populations and are increasingly gaining attention as factors that may influence recovery from TBI. Positive affect, hope, optimism, adaptive coping style, and resilience have all been examined in the context of TBI...
July 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29781723/strengths-in-older-adults-differential-effect-of-savoring-gratitude-and-optimism-on-well-being
#8
Isabel María Salces-Cubero, Encarnación Ramírez-Fernández, Ana Raquel Ortega-Martínez
Objetive: The present study aimed to compare the efficacy of three separate strengths training-based interventions - Gratitude, Savoring, and Optimism - in older adults. METHOD: The sample comprised 124 older adults, namely, 74 women and 50 men, non-institutionalized individuals who regularly attend day centers in the provinces of Jaén and Córdoba, southern Spain. Their ages ranged between 60 and 89 years. The measures used were Anxiety, Depression, Life Satisfaction, Positive and Negative Affect, Subjective Happiness, and Resilience...
May 21, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29781661/suicide-risk-assessment-trust-an-implicit-probe-or-listen-to-the-patient
#9
Dominique P Harrison, Werner G K Stritzke, Nicolas Fay, Abdul-Rahman Hudaib
Previous research suggests implicit cognition can predict suicidal behavior. This study examined the utility of the death/suicide implicit association test (d/s-IAT) in acute and prospective assessment of suicide risk and protective factors, relative to clinician and patient estimates of future suicide risk. Patients (N = 128; 79 female; 111 Caucasian) presenting to an emergency department were recruited if they reported current suicidal ideation or had been admitted because of an acute suicide attempt. Patients completed the d/s-IAT and self-report measures assessing three death-promoting (e...
May 21, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29781642/effects-of-aging-and-text-stimulus-quality-on-the-word-frequency-effect-during-chinese-reading
#10
Jingxin Wang, Lin Li, Sha Li, Fang Xie, Simon P Liversedge, Kevin B Paterson
Age-related reading difficulty is well established for alphabetic languages. Compared to young adults (18-30 years), older adults (65+ years) read more slowly, make more and longer fixations, make more regressions, and produce larger word-frequency effects. However, whether similar effects are observed for nonalphabetic languages like Chinese remains to be determined. In particular, recent research has suggested Chinese readers experience age-related reading difficulty but do not produce age differences in the word-frequency effect...
May 21, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29781450/music-brain-plasticity-and-the-resilience-the-pillars-of-new-receptive-therapy
#11
Helena Dukić
This paper describes a new type of receptive music therapy which aims to build the patients' psychological resilience by increasing the levels of dopamine, serotonin and oxytocin in order to increase standard psychopharmacological treatment efficiency. Previous research concerning the musically induced production of the two neurotransmitters and a hormone is discussed and reviewed. Based upon the existent studies concerning the influence of music on dopamine, serotonin and oxytocin induction, a new design of specific music features for this purpose is proposed and elaborated upon...
April 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/29781373/subliminal-gender-stereotypes-who-can-resist
#12
Jolien A van Breen, Russell Spears, Toon Kuppens, Soledad de Lemus
We examine women's responses to subliminal gender stereotypes, that is, stereotypes present outside conscious awareness. Previous research suggests that subtle stereotypes elicit acceptance and assimilation, but we predict that subliminal exposure to gender stereotypes will trigger resistance in some women. Specifically, we expect resistance to occur among women who are relatively strongly identified with feminists, but not with the broader group of women. We predict that resistance takes the form of persistence in stereotypically masculine domains and (implicit) in-group bias...
May 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29781155/human-impacts-decouple-a-fundamental-ecological-relationship-the-positive-association-between-host-diversity-and-parasite-diversity
#13
Chelsea L Wood, Brian J Zgliczynski, Alison J Haupt, Ana Sofía Guerra, Fiorenza Micheli, Stuart A Sandin
Human impacts on ecosystems can decouple the fundamental ecological relationships that create patterns of diversity in free-living species. Despite the abundance, ubiquity, and ecological importance of parasites, it is unknown whether the same decoupling effects occur for parasitic species. We investigated the influence of fishing on the relationship between host diversity and parasite diversity for parasites of coral reef fishes on three fished and three unfished islands in the central equatorial Pacific. Fishing was associated with a shallowing of the positive host-diversity-parasite-diversity relationship...
May 20, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29781019/complex-strain-induced-structural-changes-observed-in-fibrin-assembled-in-human-plasma
#14
G Portale, J Torbet
The structure of the core scaffold of blood clots, the interlinked 3-dimensional network of fibrin fibers, is modified by mechanical forces generated by platelet driven clot retraction, wound repair and shear stress through blood flow. Here X-ray diffraction is used to investigate how uniaxial strain, ε (ε = extension/original length), alters fiber structure in highly aligned human plasma clots covalently cross-linked by Factor XIIIa. Three stretch sensitive axially repeating structures are identified. Firstly, the foundation structure with an initial ≈22 nm axial repeat stretches, fades then disappears at ε ≈ 0...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29780891/mind-body-skills-training-for-resident-wellness-a-pilot-study-of-a-brief-mindfulness-intervention
#15
Laura E Romcevich, Suzanne Reed, Stacy R Flowers, Kathi J Kemper, John D Mahan
Background: Interventions to address burnout include mind-body skills training (MBST), but few studies have evaluated the feasibility of MBST for busy pediatric residents. Objective: In this pilot study, we tested the feasibility of a brief MBST intervention, using in-person peer-led training supported by online modules, to decrease stress and burnout in pediatric resident physicians. Methods: Of 99 (10%) residents, 10 residents at Nationwide Children's Hospital in Ohio participated in up to four 90-minute MBST sessions more than 1 month, led by a co-resident with 5 years of informal training in mind-body skills...
January 2018: Journal of Medical Education and Curricular Development
https://www.readbyqxmd.com/read/29780173/land-use-in-mountain-grasslands-alters-drought-response-and-recovery-of-carbon-allocation-and-plant-microbial-interactions
#16
Stefan Karlowsky, Angela Augusti, Johannes Ingrisch, Roland Hasibeder, Markus Lange, Sandra Lavorel, Michael Bahn, Gerd Gleixner
Mountain grasslands have recently been exposed to substantial changes in land use and climate and in the near future will likely face an increased frequency of extreme droughts. To date, how the drought responses of carbon (C) allocation, a key process in the C cycle, are affected by land-use changes in mountain grassland is not known.We performed an experimental summer drought on an abandoned grassland and a traditionally managed hay meadow and traced the fate of recent assimilates through the plant-soil continuum...
May 2018: Journal of Ecology
https://www.readbyqxmd.com/read/29779966/developing-and-deploying-climate-resilient-maize-varieties-in-the-developing-world
#17
REVIEW
Jill E Cairns, B M Prasanna
In sub-Saharan Africa (SSA) and Asia maize yields remain variable due to climate shocks. Over the past decade extensive progress has been made on the development and delivery of climate-resilient maize. In 2016 over 70000 metric tonnes of drought-tolerant maize seed was commercialized in 13 countries in SSA, benefiting an estimated 53 million people. Significant progress is also being made with regard to the development and deployment of elite heat-tolerant maize varieties in South Asia. Increased genetic gain in grain yield under stress-prone environments, coupled with faster replacement of old/obsolete varieties, through intensive engagement with seed companies is essential to protect maize crops grown by smallholders from the changing climates in SSA and Asia...
May 17, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29779252/germination-niche-breadth-varies-inconsistently-among-three-asclepias-congeners-along-a-latitudinal-gradient
#18
Jessamine Finch, Jeffrey L Walck, Siti N Hidayati, Andrea T Kramer, Victoria Lason, Kayri Havens
Species responses to climate change will be primarily driven by their environmental tolerance range, or niche breadth, with the expectation that broad niches will increase resilience. Niche breadth is expected to be greater in more heterogeneous environments and moderated by life history. Niche breadth also varies across life stage. Therefore, the life stage with the narrowest niche may serve as the best predictor of climatic vulnerability. To investigate the relationship between niche breadth, climate, and life stage we identify germination niche breadth for dormant and nondormant seeds in multiple populations of three milkweed (Asclepias) species...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29779059/youth-responses-to-school-shootings-a-review
#19
REVIEW
Áine Travers, Tracey McDonagh, Ask Elklit
PURPOSE OF REVIEW: This paper aims to synthesize research relating to youth responses to school shootings between 2014 and 2017. The main questions it addresses are how such events impact young people psychologically, and what risk or protective factors may contribute to different trajectories of recovery? RECENT FINDINGS: Recent research suggests that most young people exposed to school shootings demonstrate resilience, exhibiting no long-term dysfunction. However, a minority will experience severe and chronic symptoms...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29778829/a-qualitative-investigation-of-the-attitudes-and-beliefs-about-physical-activity-and-post-traumatic-osteoarthritis-in-young-adults-3-10-years-after-an-intra-articular-knee-injury
#20
Allison M Ezzat, Mariana Brussoni, Jackie L Whittaker, Carolyn A Emery
OBJECTIVE: To understand the influence of the injury experience on current attitudes and beliefs about physical activity (PA) and the development of post-traumatic osteoarthritis (PTOA) in youth and young adults 3-10 years after a sport-related knee injury. DESIGN: Qualitative study. SETTING: University Sports Medical/Research Center. PARTICIPANTS: 20 young adults 3-10 years subsequent to intra-articular knee injury...
May 4, 2018: Physical Therapy in Sport
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