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REVIEW
Penghui Ye, Rifang Gu, Huan Zhu, Jitao Chen, Felicity Han, Xuqiang Nie
The SOX family plays a vital role in determining the fate of cells and has garnered attention in the fields of cancer research and regenerative medicine. It also shows promise in the study of wound healing, as it actively participates in the healing processes of various tissues such as skin, fractures, tendons, and the cornea. However, our understanding of the mechanisms behind the SOX family's involvement in wound healing is limited compared to its role in cancer. Gaining insight into its role, distribution, interaction with other factors, and modifications in traumatized tissues could provide valuable new knowledge about wound healing...
October 6, 2023: International Journal of Biological Macromolecules
#22
JOURNAL ARTICLE
Natalí Solano-Cueva, Jorge G Figueroa, Corina Loja, Chabaco Armijos, Giovanni Vidari, Jorge Ramírez
The diphenolic diterpene carnosol was isolated from several species of the family Lamiaceae, including Lepechinia mutica , a medicinal plant endemic to Ecuador. The compound has exhibited high antioxidant, anti-inflammatory, antimicrobial, neuroprotective, and antifungal properties, as well as promising cytotoxicity against prostate, breast, skin, leukemia, and human colon cancer cell lines. In this paper, we developed and validated a simple, accurate, and reliable analytical HPLC-UV-ESI-IT-MS method, carried out on a C18 column, which is potentially suitable to quantify carnosol in plant extracts...
September 19, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#23
JOURNAL ARTICLE
Jazmin Newton
INTRODUCTION: Previous studies have established that geographic location strongly influences health literacy, access to care, and health outcomes across all disease types. There are many well-understood risk factors for the development of melanoma, and likewise various markers of disease severity. However, few studies have been conducted to determine what role locality and access to dermatological care play in both the incidence and severity of melanoma, particularly in South Dakotans...
September 2023: South Dakota Medicine: the Journal of the South Dakota State Medical Association
#24
MULTICENTER STUDY
(no author information available yet)
Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disorder characterized by diffuse pulmonary cysts often leading to recurrent spontaneous pneumothorax, cutaneous fibrofolliculomas or trichodiscomas, and a variety of renal cell cancers. It is caused by pathogenic variants in the FLCN gene located on chromosome 17p11.2. Although an increasing number of patients with BHD syndrome are being recognized in China, the missed diagnosis and delayed diagnosis are still common. In addition, appropriate management is difficult for most of them...
September 12, 2023: Chinese Journal of Tuberculosis and Respiratory Diseases
#25
JOURNAL ARTICLE
Jian-Li Gao, Xue-Hong Wang, Zhen-Qi Ma, Sheng-Sen Yang, Hong-Bin Shi
Objective To analyze the expression of cyclooxygenase-2 (COX-2) in the patients with snow-white sign of advanced colorectal adenoma (ACA) and explore its clinical significance.Method Western blotting was employed to determine the expression of COX-2 in the adenoma tissue and the normal tissue adjacent to the adenoma tissue (>5 cm away from the distal end of the adenoma tissue) of 40 ACA patients with snow-white sign and 40 ACA patients without snow-white sign.Results The appearance of snow-white sign in ACA patients was associated with patient age ( P =0...
August 2023: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
#26
JOURNAL ARTICLE
Nimit N Shah, Michael B Steinberg, Alberto J Caban-Martinez, Elena Austin, Jefferey L Burgess, Brittany S Hollerbach, Derrick L Edwards, Taylor M Black, Kathleen Black, Kaleigh M Hinton, Brian S Kubiel, Judith M Graber
BACKGROUND: Firefighters have a higher risk of melanoma incidence and mortality compared to the general population. In the United States (US), the National Fire Protection Association recommends all firefighters receive annual skin cancer screening through visual skin examination by a clinician. However, there is limited information on skin cancer screening practices among volunteer firefighters who comprise two-thirds of the US fire service. METHODS: This cross-sectional study of 552 US volunteer firefighters estimated the prevalence of skin cancer screening and evaluated associations with their fire service experience, demographics, sun protection practices, and cancer risk perception...
August 12, 2023: American Journal of Industrial Medicine
#27
Elizabeth Swezey, Rodrigo Blake, Sarah Alamprese, Teresa Luong, Lambros D G Angus
The cutaneous metastasis of colon cancer is rare, and most commonly manifests as nodules or masses. In the case of our patient, a rarely described vesiculomaculopapular rash resembling herpes zoster was observed and treated as such; however, biopsy later revealed metastatic colonic adenocarcinoma. Metastasis of colon cancer to the skin typically confers a poor prognosis, however, early identification may allow for quicker intervention and more aggressive treatments, that may extend survival. Given the immunocompromised state of cancer patients undergoing antineoplastic therapy, a herpes zoster eruption would not be unexpected, but an astute primary care provider should keep metastatic disease in their differential...
May 2023: Journal of Family Medicine and Primary Care
#28
JOURNAL ARTICLE
Yen-Chen Tung, Ping-Hua Sung, Pei-Chun Chen, Hsiao Chi Wang, Jong Hun Lee, Zheng-Yuan Su
BACKGROUND AND AIM: Skin is one barrier protecting from environmental risk factors that can make skin cells cancerous through DNA damage and oxidative stress. The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is an anti-stress defense system that can be regulated by DNA methylation and histone modification. Dietary phytochemicals have chemopreventive properties that can inhibit or delay carcinogenesis. The lotus leaf is a traditional medicinal plant containing many polyphenols whose extracts show many biological activities, including antioxidant, anti-obesity, and anti-cancer...
July 2023: Journal of Traditional and Complementary Medicine
#29
REVIEW
Parvaneh Sheydaei, Ana Paula Duarte
This review provides a comprehensive overview of the botany, traditional uses, phytochemistry, pharmacology, and toxicity of the genus Tripleurospermum . Tripleurospermum , a prominent genus within the family Asteraceae, is recognized for its therapeutic potential in treating various ailments, including skin, digestive, and respiratory diseases; cancer; muscular pain; and stress and as a sedative. Through extensive phytochemical studies regarding the Tripleurospermum species, numerous chemical compounds have been identified and classified into distinct classes, predominantly encompassing terpenes, hydrocarbons, steroids, hydrocarbons, oxygenated compounds, flavonoids, tannins, alcohols, acids, melatonin, and fragrant compounds...
June 5, 2023: Life
#30
REVIEW
Nguyen Thi Huong, Ninh The Son
Pharmacological studies on flavonoids have always drawn much interest for many years. Icaritin (ICT), a representative flavone containing an 8-prenyl group, is a principal compound detected in medicinal plants of the genus Epimedum, the family Berberidaceae. Experimental results in the phytochemistry and pharmacology of this molecule are abundant now, but a deep overview has not been carried out. The goal of this review is to provide an insight into the natural observation, biosynthesis, biotransformation, synthesis, pharmacology, and pharmacokinetics of prenyl flavone ICT...
June 23, 2023: Phytochemistry
#31
JOURNAL ARTICLE
SeHo Shin, KiHyun Kim, SangSeok Woo, KyungMin Kim, JunWon Lee, SeongHwan Kim, JaiKoo Choi, DongJin Lee, InSuck Suh
RATIONALE: Although regional metastasis to the lymph nodes is common in advanced oral cancer, extensive local invasion into surrounding structures such as the mandible, skin and soft tissue of the neck, and masticator space is relatively rare. Sometimes surgical treatment cannot be performed and only palliative chemotherapy and radiation therapy are offered to preserve the quality of life of patients with advanced oral cancer. Nevertheless, the surgical resection of tumors remains the most effective treatment...
May 26, 2023: Medicine (Baltimore)
#32
JOURNAL ARTICLE
Liqiong Liu, Yang Yu, Juan Xia, Yanting Ning
RATIONALE: Immune-related adverse events are occasionally reported in Sintilimab treatment. This study reports a forward and reverse swelling case along the vein after infusion of Sintilimab. At present, swelling along the vascular direction during peripheral infusion are limitedly reported at home and abroad, especially when choosing a vein with thick, elastic, and good blood return. PATIENT CONCERNS: A 56-year-old male who suffered from esophageal cancer and liver cancer and received albumin-bound paclitaxel and nedaplatin chemotherapy in combination with Sintilimab immunotherapy appeared swelling along the vessel after infusion of Sintilimab...
May 26, 2023: Medicine (Baltimore)
#33
REVIEW
Minghui Li, Wei Jiang, Zehui Wang, Yihan Lu, Jun Zhang
Interleukin (IL)-36 is a member of the IL-1 superfamily, which includes three receptor agonists and one antagonist and exhibits a familial feature of inflammatory regulation. Distributed among various tissues, such as the skin, lung, gut and joints, the mechanism of IL-36 has been most completely investigated in the skin and has been used in clinical treatment of generalized pustular psoriasis. Meanwhile, the role of IL-36 in the intestine has also been under scrutiny and has been shown to be involved in the regulation of various intestinal diseases...
June 2023: Experimental and Therapeutic Medicine
#34
JOURNAL ARTICLE
Sameer Ullah Khan, Baseerat Hamza, Reyaz Hassan Mir, Kaneez Fatima, Fayaz Malik
Natural remedies from a range of sources, including plants, animals, microorganisms, and marine life, have made a significant contribution to the treatment of many ailments. Lavender is a Mediterranean shrub from the Lamiaceae family. Lavender flowers (Lavandula flores) include active ingredients (3%), anthocyanins, sugars, phytosterols, minerals, and tannins and are majorly used for herbal applications. Lavender essential oil's descriptive and analytical composition varies depending on genotype, growing region, climatic circumstances, propagation, and morphological characteristics...
May 18, 2023: Current Molecular Medicine
#35
REVIEW
Jiayu Wang, Jifa Zhang, Jiaxing Wang, Xinyue Hu, Liang Ouyang, Yuxi Wang
Toll-like receptors (TLRs) are key components of the innate immune system and serve as a crucial link between innate and acquired immunity. In addition to immune function, TLRs are involved in other important pathological processes, including tumorigenesis. TLRs have dual regulatory effects on tumor immunity by activating nuclear factor κ-B signaling pathways, which induce tumor immune evasion or enhance the antitumor immune response. Therefore, TLRs have become a popular target for cancer prevention and treatment, and TLR agonists and antagonists offer considerable potential for drug development...
May 10, 2023: Journal of Medicinal Chemistry
#36
REVIEW
Kiran Shahane, Madhuri Kshirsagar, Srushti Tambe, Divya Jain, Srutee Rout, Maria Karolina Martins Ferreira, Suraj Mali, Purnima Amin, Prem Prakash Srivastav, Jorddy Cruz, Rafael Rodrigues Lima
Calendula officinalis Linn. (CO) is a popular medicinal plant from the plant kingdom's Asteraceae family that has been used for millennia. This plant contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil, amino acids, steroids, sterols, and quinines. These chemical constituents confer multifaceted biological effects such as anti-inflammatory, anti-cancer, antihelminthic, antidiabetes, wound healing, hepatoprotective, and antioxidant activities. Additionally, it is employed in cases of certain burns and gastrointestinal, gynecological, ocular, and skin conditions...
April 18, 2023: Pharmaceuticals
#37
JOURNAL ARTICLE
Romy Walker, Khalid Mahmood, Jihoon E Joo, Mark Clendenning, Peter Georgeson, Julia Como, Sharelle Joseland, Susan G Preston, Yoland Antill, Rachel Austin, Alex Boussioutas, Michelle Bowman, Jo Burke, Ainsley Campbell, Simin Daneshvar, Emma Edwards, Margaret Gleeson, Annabel Goodwin, Marion T Harris, Alex Henderson, Megan Higgins, John L Hopper, Ryan A Hutchinson, Emilia Ip, Joanne Isbister, Kais Kasem, Helen Marfan, Di Milnes, Annabelle Ng, Cassandra Nichols, Shona O'Connell, Nicholas Pachter, Bernard J Pope, Nicola Poplawski, Abiramy Ragunathan, Courtney Smyth, Allan Spigelman, Kirsty Storey, Rachel Susman, Jessica A Taylor, Linda Warwick, Mathilda Wilding, Rachel Williams, Aung K Win, Michael D Walsh, Finlay A Macrae, Mark A Jenkins, Christophe Rosty, Ingrid M Winship, Daniel D Buchanan
Routine screening of tumors for DNA mismatch repair (MMR) deficiency (dMMR) in colorectal (CRC), endometrial (EC) and sebaceous skin (SST) tumors leads to a significant proportion of unresolved cases classified as suspected Lynch syndrome (SLS). SLS cases (n = 135) were recruited from Family Cancer Clinics across Australia and New Zealand. Targeted panel sequencing was performed on tumor (n = 137; 80×CRCs, 33×ECs and 24xSSTs) and matched blood-derived DNA to assess for microsatellite instability status, tumor mutation burden, COSMIC tumor mutational signatures and to identify germline and somatic MMR gene variants...
April 26, 2023: Journal of Translational Medicine
#38
JOURNAL ARTICLE
Aisha Nawaz, Sumera Zaib, Imtiaz Khan, Abrar Ahmed, Kiran Shahzadi, Huma Riaz
Silybum Marianum (SM) belongs to the family Asteraceae, which holds therapeutic significance in medicinal chemistry. Phytochemistry analysis revealed an abundance of active constituents, particularly silymarin, composed of polyphenols and flavonolignans. Silymarin is majorly found in leaves, seeds, and fruits and is comprised of seven flavonolignans. Silymarin derivatives, specifically silybin, were reported for their medicinal properties. This review summarizes the studies conducted to evaluate SM's pharmacological properties and proposed mechanisms...
April 12, 2023: Anti-cancer Agents in Medicinal Chemistry
#39
JOURNAL ARTICLE
Aiman Aslam, Zaki Arshad, Amir Ahmed, Chien Lin Soh, Fawz Kazzazi, John R Benson, Parto Forouhi, Amit Agrawal, Sarah L Benyon, Michael Irwin, Charles M Malata
INTRODUCTION: Bilateral risk-reducing mastectomy (BRRM) involves removal of healthy breast tissue to substantially decrease the risk of developing breast cancer in individuals with greater susceptibility due to a strong family history or genetic mutation. This retrospective study evaluates cases of BRRM and associated reconstruction performed at a tertiary centre, with emphasis on mastectomy and reconstructive trends. METHODS: A retrospective review of all BRRM cases performed between January 2010 and May 2022 was conducted, with two separate cohorts corresponding to the earlier (group 1) and later (group 2) portion of the time-period...
2023: PloS One
#40
JOURNAL ARTICLE
Miranda D Lu, Richard Usatine, James Holt, Diane M Harper, Alexandra Verdieck
BACKGROUND AND OBJECTIVES: Diagnosing skin disorders is a core skill in family medicine residency. Accurate diagnosis of skin cancers has a significant impact on patient health. Dermoscopy improves a physician's accuracy in diagnosing skin cancers. We aimed to quantify the current state of dermoscopy use and training in family medicine residencies. METHODS: We included questions on dermoscopy training in the 2021 Council of Academic Family Medicine Educational Research Alliance (CERA) survey of family medicine residency program directors...
April 2023: Family Medicine
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