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Skin cancer, family medicine

Pratibha Chaturvedi, Vincent Briganza
BACKGROUND: Curculigo orchioides Gaertn (Kali musli; Family: Hypoxidaceae) is an endangered medicinal plant used for many medicinal purposes such as impotency, aphrodisiac, tonic, jaundice, and skin ailments. Its hepatoprotective, antioxidant, and anti-cancerous potential have also been evaluated by many scientists. OBJECTIVE: The objective of this study is to enhance the curculigoside content in tissue culture of C. orchioides. MATERIALS AND METHODS: The present study deals with the enhancement of an active compound of C...
July 2016: Pharmacognosy Research
Hidenori Kashihara, Takeo Nakayama, Taichi Hatta, Naomi Takahashi, Misao Fujita
BACKGROUND: Although the safety and effectiveness of stem cell therapies are yet to be proven, recent studies show that such therapies are being advertised with some questionable marketing techniques to effect positive portrayal of the therapies on the webpages of private-practice clinics to sell their therapies worldwide. In such context, those clinics communicate directly with consumers (patients and their family members) via the clinics' websites. Meanwhile, the Health Science Council at the Ministry of Health, Labour, and Welfare (MHLW) in Japan has pointed out noncompliance of some local clinics with the provisions concerning medical advertising in the Medical Care Act in the past...
2016: Interactive Journal of Medical Research
Alessandra Russo, Venera Cardile, Adriana C E Graziano, Daniela Rigano, Abdurrahman Aktumsek, Gokhan Zengin, Felice Senatore
Centaurea is the largest genus within the Asteraceae family. Many members of this genus are used in traditional folk medicine, such as Centaurea pulchella used to treat skin problems such as to resolve the abscess. Although biological activities of many Centaurea species have been investigated in different countries and Turkey, cytotoxic effect of C. patula, C. pulchella and C. tchihatcheffii has not been studied yet. Melanoma is one of the most invasive and deadly forms of skin cancer. Therefore, in an ongoing effort to identify new natural anticancer products for the treatment and/or prevention of melanoma cancer, the present study was undertaken to investigate the effect of these Centaurea species, collected from Central Anatolia region of Turkey on cell growth and death in human melanoma cell line, A375...
March 2016: Natural Product Communications
Ewelina Bogumiła Zuba, Wojciech Francuzik, Przemysław Malicki, Agnieszka Osmola-Mańkowska, Dorota Jenerowicz
Dear Editor, Ultraviolet (UV) radiation is a well-known physical hazard responsible for photoaging, photoallergic, and phototoxic reactions as well as carcinogenesis, including life-threatening melanomas (1,2). Overexposure to both natural and artificial UV radiation is a public health concern. 30% of cancers diagnosed worldwide are skin cancers. Approximately three million non-melanoma skin cancers and 132 000 new cases of melanomas are diagnosed globally each year (3). Sunburns, especially in childhood, are a very important risk factor for melanomas...
April 2016: Acta Dermatovenerologica Croatica: ADC
Abdel-Naser B Singab, Hala M El-Hefnawy, Ahmed Esmat, Haidy A Gad, Jilan A Nazeam
Since ancient times, plants and herbal preparations have been used as medicine. Research carried out in the last few decades has verified several such claims. Aloe arborescens Miller, belonging to the Aloe genus (Family Asphodelaceae), is one of the main varieties of Aloe used worldwide. The popularity of the plant in traditional medicine for several ailments (antitumor, immunomodulatory, antiinflammatory, antiulcer, antimicrobial and antifungal activity) focused the investigator's interest on this plant. Most importantly, the reported studies have shown the plant effectiveness on various cancer types such as liver, colon, duodenal, skin, pancreatic, intestinal, lung and kidney types...
December 2015: Phytotherapy Research: PTR
Thao T Nguyen, Marie-Odile Parat, Mark P Hodson, Jenny Pan, Paul N Shaw, Amitha K Hewavitharana
In traditional medicine, Carica papaya leaf has been used for a wide range of therapeutic applications including skin diseases and cancer. In this study, we investigated the in vitro cytotoxicity of aqueous and ethanolic extracts of Carica papaya leaves on the human oral squamous cell carcinoma SCC25 cell line in parallel with non-cancerous human keratinocyte HaCaT cells. Two out of four extracts showed a significantly selective effect towards the cancer cells and were found to contain high levels of phenolic and flavonoid compounds...
January 2016: Toxins
Tanja Planinšek Ručigaj, Kristina Janežič, Jasna Lipozenčić
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
Huma Qureshi, Saira Asif, Haroon Ahmed, Hassan A Al-Kahtani, Khizar Hayat
Members of the family Zygophyllaceae are distributed in arid areas of the world and are traditionally used against various health insults ranging from skin lesions to lethal cancer. Fagonia cretica Linn. is a plant having novel compounds responsive in diseases that are still considered as incurable or are curable with serious side effects. Researchers, particularly of the Asian region elaborately studied the chemical composition and pharmacological activities of this plant. But further studies are still required to evaluate this plant in clinical trials in order to save humanity from synthetic chemical drugs yet disputed as 'friends or foe'...
2016: Natural Product Research
M H Shoja, Neetinkumar D Reddy, Pawan G Nayak, K K Srinivasan, C Mallikarjuna Rao
ETHNOPHARMACOLOGICAL RELEVANCE: Glycosmis pentaphylla (Retz.) DC belonging to the family Rutaceae has been traditionally used for the treatment of rheumatism, anaemia, jaundice, skin diseases, bronchitis etc. The plant is traditionally considered as anti-cancer medicine and used by the healers of Bangladesh to treat all types of cancers. Perhaps the key to many of its medicinal applications is its inherent anti-inflammatory property. AIM OF THE STUDY: The present study is aimed at evaluating the effect of various fractions of G...
June 20, 2015: Journal of Ethnopharmacology
Nu Ry Song, Jong-Eun Kim, Jun Seong Park, Jong Rhan Kim, Heerim Kang, Eunjung Lee, Young-Gyu Kang, Joe Eun Son, Sang Gwon Seo, Yong Seok Heo, Ki Won Lee
Licorice is a traditional botanical medicine, and has historically been commonly prescribed in Asia to treat various diseases. Glycyrrhizin (Gc), a triterpene compound, is the most abundant phytochemical constituent of licorice. However, high intake or long-term consumption of Gc has been associated with a number of side effects, including hypertension. However, the presence of alternative bioactive compounds in licorice with anti-carcinogenic effects has long been suspected. Licochalcone A (LicoA) is a prominent member of the chalcone family and can be isolated from licorice root...
2015: International Journal of Molecular Sciences
Lori Diseati, Laura B Scheinfeldt, Rachel S Kasper, Ruixue Zhaoyang, Neda Gharani, Tara J Schmidlen, Erynn S Gordon, Cecili K Sessions, Susan K Delaney, Joseph P Jarvis, Norman Gerry, Michael Christman
There is currently great interest in using genetic risk estimates for common disease in personalized healthcare. Here we assess melanoma risk-related preventive behavioral change in the context of the Coriell Personalized Medicine Collaborative (CPMC). As part of on-going reporting activities within the project, participants received a personalized risk assessment including information related to their own self-reported family history of melanoma and a genetic risk variant showing a moderate effect size (1...
2015: Journal of Personalized Medicine
Ignacio G Bravo, Marta Félez-Sánchez
Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides only limited protection against reinfection. Most PVs are part and parcel of the skin microbiota. In some cases, infections by certain PVs take diverse clinical presentations from highly productive self-limited warts to invasive cancers. We propose PVs as an excellent model system to study the evolutionary interactions between the immune system and pathogens causing chronic infections: genotypically, PVs are very diverse, with hundreds of different genotypes infecting skin and mucosa; phenotypically, they display extremely broad gradients and trade-offs between key phenotypic traits, namely productivity, immunogenicity, prevalence, oncogenicity and clinical presentation...
2015: Evolution, Medicine, and Public Health
Richard S Kalman, Kevan Hartshorn, Francis A Farraye
The medical treatment for inflammatory bowel disease (IBD) has improved over the past 20 years. Although the routine use of immunomodulators and biologic agents in the treatment of IBD in the modern era has been a great achievement, these medicines are associated with rare but serious adverse events. In addition to the infectious complications, there are data to suggest that some of these agents are associated with higher rates of malignancy. In a patient with a history of cancer, or a family history of cancer, the gastroenterologist must be prepared to answer questions about the oncogenic potential of these agents...
February 2015: Inflammatory Bowel Diseases
Diane K Luci, J Brian Jameson, Adam Yasgar, Giovanni Diaz, Netra Joshi, Auric Kantz, Kate Markham, Steve Perry, Norine Kuhn, Jennifer Yeung, Edward H Kerns, Lena Schultz, Michael Holinstat, Jerry L Nadler, David A Taylor-Fishwick, Ajit Jadhav, Anton Simeonov, Theodore R Holman, David J Maloney
Human lipoxygenases (LOXs) are a family of iron-containing enzymes which catalyze the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Our group has taken a particular interest in platelet-type 12-(S)-LOX (12-LOX) because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer...
January 23, 2014: Journal of Medicinal Chemistry
Dominic O Ochwang'i, Charles N Kimwele, Jemimah A Oduma, Peter K Gathumbi, James M Mbaria, Stephen G Kiama
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine plays a critical role in treatment of chronic debilitating and life threatening conditions and diseases. Cancer is one such condition whose therapeutic intervention is commonly through inexpensive traditional herbal remedies. Increasingly industrialised societies are developing drugs and chemotherapeutics from these traditional herbal plants. Plant biogeography determines the abundance and availability of medicinal plants which in turn determine their use by local communities...
February 12, 2014: Journal of Ethnopharmacology
Madhuri Hegde, Mathew Ferber, Rong Mao, Wade Samowitz, Arupa Ganguly
Lynch syndrome, familial adenomatous polyposis, and Mut Y homolog (MYH)-associated polyposis are three major known types of inherited colorectal cancer, which accounts for up to 5% of all colon cancer cases. Lynch syndrome is most frequently caused by mutations in the mismatch repair genes MLH1, MSH2, MSH6, and PMS2 and is inherited in an autosomal dominant manner. Familial adenomatous polyposis is manifested as colonic polyposis caused by mutations in the APC gene and is also inherited in an autosomal dominant manner...
January 2014: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Luiz A E Pollo, Cristiane F Bosi, Andrea S Leite, Caroline Rigotto, Jadel Kratz, Claudia M O Simões, David E P Fonseca, Daniel Coimbra, Giovanni Caramori, Angelita Nepel, Francinete R Campos, Andersson Barison, Maique W Biavatti
Polyacetylenes constitute an underexplored and unstable class of compounds that are found mainly in the Apiaceae, Araliaceae and Asteraceae families. Vernonia scorpioides (Lam.) Pers., Asteraceae is a lianous neotropical herb that usually grows in soils that have been deforested and are of poor quality. It is used in folk medicine for the treatment of several skin conditions. This study addresses the characterisation of eight polyacetylenes isolated from the leaves of V. scorpioides. Their structures were established on the basis of 1D and 2D NMR spectroscopy and MS analysis...
November 2013: Phytochemistry
C C Carneiro, C R Silva, A C S Menezes, C N Pérez, L Chen-Chen
Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as "bacupari", "cascudo", and "saputá", is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of S. crassifolia stem bark fractions (hexane, ethyl acetate, and hydroalcoholic extracts) were evaluated using the mouse bone marrow micronucleus test...
2013: Genetics and Molecular Research: GMR
Joon Wοο Lee, Cheol Park, Min Hο Han, Su Hyun Hong, Tae Kyung Lee, Shin Hwa Lee, Gi-Young Kim, Yung Hyun Choi
Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not yet been clearly elucidated. In the present study, we investigated the pro-apoptotic effects of an ethanol extract of D. morbifera stem bark (EEDM) on human leukemia U937 cells. EEDM markedly inhibited the growth of U937 cells by decreasing cell proliferation and inducing apoptosis...
September 2013: Oncology Reports
Rodolfo Dizon, Nino Jessielito Doydora, Ricardo Salonga, Jose Edzel Tamayo, Catherine Lynn Silao, Megan Devine, Christine Kim Garcia, J Jose Turla, Gener Idor
SESSION TYPE: Pleural Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: A spontaneous pneumothorax is defined as air entering the pleural space without antecedent trauma to the thorax. This may be sub-classified into primary spontaneous pneumothorax (PSP) - occurring in the absence of an underlying lung disease. A subtype of PSP is classified as familial. Here, we present the first Filipino family documented to have Birt-Hogg-Dube (BHD) Syndrome - an autosomal dominant condition manifesting as familial primary spontaneous pneumothorax...
October 1, 2012: Chest
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