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https://www.readbyqxmd.com/read/28550489/impedance-ph-monitoring-for-diagnosis-of-reflux-disease-new-perspectives
#1
REVIEW
Marzio Frazzoni, Nicola de Bortoli, Leonardo Frazzoni, Salvatore Tolone, Vincenzo Savarino, Edoardo Savarino
Heartburn is the most specific symptom of gastroesophageal reflux disease (GERD). In clinical practice, heartburn relief by a proton pump inhibitor (PPI) trial does suffice to confirm GERD. However, an objective diagnosis of GERD is required before anti-reflux endoscopic or surgical interventions, independently from PPI response. Thus, since normal findings at upper endoscopy are detected in the majority of patients with heartburn, reflux monitoring is often required. When traditional catheter-based or wireless pH tests are used, reflux episodes are conventionally identified by pH drops below 4...
May 26, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28550457/treatment-of-juvenile-dermatomyositis-an-update
#2
REVIEW
Charalampia Papadopoulou, Lucy R Wedderburn
The idiopathic inflammatory myopathies of childhood consist of a heterogeneous group of autoimmune diseases characterised by proximal muscle weakness and pathognomonic skin rashes. The overall prognosis of juvenile myositis has improved significantly over recent years, but the long-term outcome differs substantially from patient to patient, suggestive of distinct clinical phenotypes with variable responses to treatment. High doses of corticosteroids remain the cornerstone of therapy along with other immunosuppressant therapies depending on disease severity and response...
May 26, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28550004/an-mhealth-app-for-supporting-quitters-to-manage-cigarette-cravings-with-short-bouts-of-physical-activity-a-randomized-pilot-feasibility-and-acceptability-study
#3
Mary Hassandra, Taru Lintunen, Martin S Hagger, Risto Heikkinen, Mauno Vanhala, Tarja Kettunen
BACKGROUND: While gains in reducing smoking rates in Finland have been made, prevalence rates are still substantial. Relapse rates among smokers engaged in quit-smoking programs are high. Physical activity has been proposed as one means to help smokers manage cravings. Software and apps on mobile phone and handheld devices offer an opportunity to communicate messages on how to use physical activity to manage cravings as part of quit-smoking programs. OBJECTIVE: We aimed to test the feasibility, acceptability, usability, and preliminary efficacy of an mHealth mobile phone app, Physical activity over Smoking (PhoS), to assist smokers in quitting smoking in a randomized controlled trial...
May 26, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28549107/physical-functioning-among-older-adults-new-to-long-term-services-and-supports
#4
Jo-Ana D Chase, Karen B Hirschman, Alexandra L Hanlon, Liming Huang, Kathryn H Bowles, Mary D Naylor
Background and Objectives: To identify determinants of self-reported physical functioning (PF) among older adults new to long-term services and supports (LTSS). Research Design and Method: Using the International Classification of Function, Disability, and Health (ICF) framework, we conducted a secondary analysis of self-reported data on symptoms, basic/instrumental activities of daily living, quality of life, assistive devices, physical therapy needs, prior healthcare utilization, health status, and demographics from 470 older adults new to LTSS (Home/Community-Based n = 156; Assisted Living n = 156; Nursing Home n = 158)...
May 25, 2017: Gerontologist
https://www.readbyqxmd.com/read/28549042/spontaneous-union-of-an-accidentally-fractured-proximal-segment-during-vertical-ramus-osteotomy
#5
Tae Hoon Yu, Hun Jun Lim, Jun Lee, Bong Chul Kim
After sawing in the intraoral vertical ramus osteotomy, in the case of an incomplete amputation, the proximal segment is split using the osteotome. Unfortunately, in this case, the proximal segment was accidentally fractured. The operation was completed without performing any other fixation. Postoperatively intermaxillary fixation was performed and kept for a week, followed by physical therapy, which was initiated immediately after. The patient was closely observed for 6 months. No abnormal findings were detected clinically, and the union of bone was verified...
May 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28548888/an-interdisciplinary-intervention-for-fear-of-falling-lessons-learned-from-two-case-studies
#6
James B Robinson, Julie Loebach Wetherell
This article describes two case studies using an interdisciplinary intervention for homebound older adults who experience fear of falling, resulting in debility and isolation. The patients discussed received separate home visits from a physical therapist (two and four visits) and psychologist (six and eight visits) and intervention components included an initial assessment of physical ability, prescription of home exercise program, exposure therapy, and cognitive restructuring. Both patients reported satisfaction with the fear of falling intervention and showed improved ability to walk, both in distance and in requiring less assistance...
May 12, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28548315/aapm-medical-physics-practice-guideline-8-a-linear-accelerator-performance-tests
#7
Koren Smith, Peter Balter, John Duhon, Gerald A White, David L Vassy, Robin A Miller, Christopher F Serago, Lynne A Fairobent
PURPOSE: The purpose of this guideline is to provide a list of critical performance tests in order to assist the Qualified Medical Physicist (QMP) in establishing and maintaining a safe and effective quality assurance (QA) program. The performance tests on a linear accelerator (linac) should be selected to fit the clinical patterns of use of the accelerator and care should be given to perform tests which are relevant to detecting errors related to the specific use of the accelerator. METHODS: A risk assessment was performed on tests from current task group reports on linac QA to highlight those tests that are most effective at maintaining safety and quality for the patient...
May 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28547820/future-of-medical-physics-real-time-mri-guided-proton-therapy
#8
Bradley M Oborn, Stephen Dowdell, Peter E Metcalfe, Stuart Crozier, Radhe Mohan, Paul J Keall
With the recent clinical implementation of real-time MRI guided x-ray beam therapy (MRXT), attention is therapy (MRPT). MRI guidance for proton beam therapy is expected to offer a compelling improvement to the turning to the concept of combining real-time MRI guidance with proton beam therapy; MRI guided proton beam current treatment workflow which is warranted arguably more than for x-ray beam therapy. This argument is born out of the fact that proton therapy toxicity outcomes are similar to that of the most advanced IMRT treatments, despite being a fundamentally superior particle for cancer treatment...
May 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28545937/treatment-of-nafld-with-diet-physical-activity-and-exercise
#9
REVIEW
Manuel Romero-Gómez, Shira Zelber-Sagi, Michael Trenell
Lifestyle intervention can be useful across all the spectrum of NAFLD patients. Losing weight decreases cardiovascular / diabetes risk and also regresses liver disease. Weight reductions of ≥ 10% are required for inducing near universal NASH resolution or fibrosis improvement by at least one stage. However, modest weight losses (>5%) also produce important benefits on NAS and its components. In addition, to improve the success of this intervention we need to explore, beyond total calories and type of weight loss diet, the role of micro and macronutrients, evidence-based benefits of physical activity and exercise and finally supporting these modifications through established behaviour change models and techniques...
May 22, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28544575/analysis-of-physical-characteristics-of-tumor-treating-fields-for-human-glioblastoma
#10
Edwin Lok, Pyay San, Van Hua, Melissa Phung, Eric T Wong
Tumor Treating Fields (TTFields) therapy is an approved treatment that has known clinical efficacy against recurrent and newly diagnosed glioblastoma. However, the distribution of the electric fields and the corresponding pattern of energy deposition in the brain are poorly understood. To evaluate the physical parameters that may influence TTFields, postacquisition MP-RAGE, T1 and T2 MRI sequences from a responder with a right parietal glioblastoma were anatomically segmented and then solved using finite-element method to determine the distribution of the electric fields and rate of energy deposition at the gross tumor volume (GTV) and other intracranial structures...
May 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28543610/metallic-nanoparticles-irradiated-by-low-energy-protons-for-radiation-therapy-are-there-significant-physical-effects-to-enhance-the-dose-delivery
#11
Anne-Catherine Heuskin, Bernard Gallez, Olivier Feron, Philippe Martinive, Carine Michiels, Stéphane Lucas
PURPOSE: To identify which physical properties of nanoparticles are correlated to the survival fraction of cells exposed in vitro to low energy protons in combination with nanoparticles. METHODS: The Geant4 simulation toolkit (version 10.3) was used to model nanoparticles of different sizes (5 to 50 nm) and materials (Ti, Zr, Hf, Ta, Au, Pt), with or without an organic capping ensuring biocompatibility and to irradiate them with 1.3 or 4 MeV protons and 5.3 MeV alpha particles...
May 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28543396/functional-and-structural-assessment-of-the-effect-of-human-umbilical-cord-blood-mesenchymal-stem-cells-in-doxorubicin-induced-cardiotoxicity
#12
Somia H Abd Allah, Samia Hussein, Mai M Hasan, Raghda H A Deraz, Wafaa F Hussein, Laila M E Sabik
Cardiomyopathy induced by doxorubicin (DOX) was recognized at an early stage and also several years after drug administration. Mesenchymal stem cells (MSCs) have many properties that make them suitable for preventive and/ or regenerative therapies. In this study, we evaluated the effect of MSCs in the functional and the structural improvement of DOX-induced cardiomyopathy in rats. Ninety adult male albino rats were randomly divided into three equal groups of thirty rats each: Group I (control): rats received normal saline...
May 25, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28543022/sedentary-behaviour-is-a-key-determinant-of-metabolic-inflexibility
#13
Corey A Rynders, Stephane Blanc, Nathan DeJong, Daniel H Bessesen, Audrey Bergouignan
Metabolic flexibility is defined as the ability to adapt substrate oxidation rates in response to changes in fuel availability. The inability to switch between the oxidation of lipid and carbohydrate appears to be an important feature of chronic disorders such as obesity and type 2 diabetes. Laboratory assessment of metabolic flexibility has traditionally involved measurement of the respiratory quotient (RQ) by indirect calorimetry during the fasted to fed transition (e.g. mixed meal challenge) or during a hyperinsulinemic-euglycemic clamp...
May 24, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28542667/-ign-complementary-alternative-medicine-in-adolescents-with-attention-deficit-hyperactivity-disorder-and-mood-disorders
#14
María Pilar Pérez Carmona
The Complementary/Alternative Medicine (CAM) have been increasingly used by patients such as children and adolescents. The Ministry of Health in Chile (MINSAL) has recognized and regulated some CAM, although there is still unknown their effectiveness and safety of these. OBJECTIVE: Review the available evidence regarding the use of CAM in adolescents with the attention deficit hyperactivity syndrome (ADHD) and mood disorders. METHODOLOGY: A review of the related literature about this topic on PubMed, focus on the last 10 years and using as a keywords Complementary/Alternative Medicine/Therapies, Attention deficit disorder with hyperactivity, Mood disorders, and Children/Adolescents...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28542592/fatigue-in-patients-with-neuromyelitis-optica-spectrum-disorder-and-its-impact-on-quality-of-life
#15
Jin Myoung Seok, Misong Choi, Eun Bin Cho, Hye Lim Lee, Byoung Joon Kim, Kwang Ho Lee, Pamela Song, Eun Yeon Joo, Ju-Hong Min
Fatigue is a prevalent symptom and major burden in neuroimmunological diseases. In neuromyelitis optica spectrum disorder (NMOSD), a severe autoimmune central nervous system (CNS) inflammatory disease with autoantibodies reactive to aquaporin-4, there are few reports about fatigue and quality of life (QOL). We aimed to evaluate the severity of fatigue and its relationship with QOL in patients with NMOSD. We prospectively studied patients with NMOSD who were in remission and seropositive for anti-aquaporin-4 antibody, and they were divided into 2 groups based on the presence of fatigue assessed using the Functional Assessment of Chronic Illness Therapy-fatigue score...
2017: PloS One
https://www.readbyqxmd.com/read/28542112/effects-of-vestibular-rehabilitation-on-gait-performance-in-poststroke-patients-a-pilot-randomized-controlled-trial
#16
Tsubasa Mitsutake, Maiko Sakamoto, Kozo Ueta, Shinichiro Oka, Etsuo Horikawa
The effects of vestibular rehabilitation on poststroke patients are unknown. This study aimed to investigate whether or not vestibular rehabilitation would improve both the vestibulo-ocular reflex and gait performance of patients with poststroke hemiparesis. Twenty-eight patients with stroke were assigned randomly to either an experimental group (N=14) or a control group (N=14). The experimental group performed the conventional physical therapy for 40 min and vestibular rehabilitation for 20 min, as a 60 min session, during the first 3 weeks and then completed only the conventional intervention for 60 min for the following 3 weeks...
May 24, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28542108/contralateral-spondylolysis-and-fracture-of-the-lumbar-pedicle-in-a-young-athlete
#17
Eran Kessous, Tracy Borsinger, Ayesha Rahman, Pierre A d'Hemecourt
STUDY DESIGN: Clinical case report of unilateral pedicular stress fracture with a contralateral spondylolysis in a male high school athlete presenting with low back pain. OBJECTIVES: To report this uncommon cause of low back pain in an adolescent athlete, and review the relevant literature. SUMMARY AND BACKGROUND DATA: The incidence of spondylolysis in the caucasian population was found to be about 3-6%. This number is probably higher in the athletic adolescent age group, with reports ranging from 8-15%...
May 24, 2017: Spine
https://www.readbyqxmd.com/read/28542072/effect-of-exercise-training-on-the-frequency-of-contracture-release-surgeries-in-burned-children
#18
Jong O Lee, David N Herndon, Clark Andersen, Oscar E Suman, Ted T Huang
BACKGROUND: Intensive physical exercise (IPE) increases strength, lean body mass, aerobic capacity, and range of motion in children with extensive burns. However, whether IPE decreases the frequency of burn scar contracture-releasing procedures in children with extensive burns is unknown. MATERIALS AND METHODS: Prospectively collected surgical records of 184 children who had undergone axilla, elbow, and/or wrist contracture-releasing procedures were reviewed. All children were 7 years or older and had sustained burns of at least 40% of the total body surface area...
May 25, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28541464/quality-and-usability-of-arthritic-pain-self-management-apps-for-older-adults-a-systematic-review
#19
Priyanka Bhattarai, Tro Newton-John, Jane L Phillips
Objective.:  To appraise the quality and usability of currently available pain applications that could be used by community-dwelling older adults to self-manage their arthritic pain. Methods. : A systematic review. Searches were conducted in App Store and Google Play to identify pain self-management apps relevant to arthritic pain management. English language pain management apps providing pain assessment and documentation function and pain management education were considered for inclusion...
May 25, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28541100/patient-education-and-mind-diversion-in-supportive-care
#20
Salima Sadruddin, Rafat Jan, Adnan A Jabbar, Kashmira Nanji, Ambreen Tharani Name
Cancer is a growing health problem worldwide. Common treatments include surgery, chemotherapy and radiation therapy. Systemic anti-cancer medications often result in an array of physical and psychological side effects. Supportive care assists patients with cancer in managing multidimensional symptoms that result from treatment or the illness itself. This review discusses supportive care and examines patient counselling and mind-diversion activities, which are safe and cost-effective strategies. Improving cancer patients' health and wellbeing should be encouraged in oncology nursing practice and by teaching students the knowledge and skills needed to provide supportive care...
May 25, 2017: British Journal of Nursing: BJN
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