keyword
https://read.qxmd.com/read/38544063/upper-limb-electromyographic-responses-to-motor-imagery-and-action-observation-in-acquired-brain-injury
#21
JOURNAL ARTICLE
Sara Santiago-Martín, Ana Belén Calvo-Vera, Beatriz María Bermejo-Gil, Ana María Martín-Nogueras
Acquired Brain Injuries are one of the leading causes of mortality and disability worldwide. One of the most frequent sequelae is motor impairment of the upper limbs, which affects people's functionality and quality of life. Following the discovery of mirror neurons, new techniques were developed based on the mechanisms of neuronal plasticity, such as motor imagery (MI) and action observation (AO). We propose a protocol using electromyographic recordings of forearm muscles in people who have suffered a stroke during an MI task and an AO task...
March 11, 2024: Sensors
https://read.qxmd.com/read/38543986/thermography-sensor-to-assess-motor-and-sensitive-neuromuscular-sequels-of-brain-damage
#22
JOURNAL ARTICLE
Alessio Cabizosu, Daniele Grotto, Alberto López López, Raúl Castañeda Vozmediano
INTRODUCTION: The aim of this study was to observe the validity, diagnostic capacity, and reliability of the thermographic technique in the analysis of sensitive and motor sequelae in patients with chronic brain damage. METHOD: A longitudinal descriptive observational study was performed. Forty-five people with impairment in at least one anatomical region participated in and completed this study. All patients who had become infected by SARS-CoV-2 in the past year were excluded...
March 7, 2024: Sensors
https://read.qxmd.com/read/38543522/the-impact-of-early-life-cecal-microbiota-transplantation-on-social-stress-and-injurious-behaviors-in-egg-laying-chickens
#23
REVIEW
Yuechi Fu, Jiaying Hu, Huanmin Zhang, Marisa A Erasmus, Timothy A Johnson, Heng-Wei Cheng
Injurious behaviors (i.e., aggressive pecking, feather pecking, and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress and related health and welfare issues as well as economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation and related neuropsychiatric disorders via the microbiota-gut-brain axis, and consequently increasing the frequency and intensity of aggression and violent behaviors...
February 26, 2024: Microorganisms
https://read.qxmd.com/read/38543098/senescence-and-sasp-are-potential-therapeutic-targets-for-ischemic-stroke
#24
REVIEW
Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial reduction. Recently, the involvement of cellular senescence and SASP in brain injury and neurological degeneration has been recognized. Ischemic injury causes oxidative stress and mitochondrial damage that induces senescence through the activation of p21 and p16 pathways, ultimately leading to synthesis and release of senescence-associated secretory phenotype (SASP)...
February 28, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542895/uncovering-the-power-of-gpr18-signalling-how-rvd2-and-other-ligands-could-have-the-potential-to-modulate-and-resolve-inflammation-in-various-health-disorders
#25
REVIEW
Ewelina Honkisz-Orzechowska, Dorota Łażewska, Grzegorz Baran, Katarzyna Kieć-Kononowicz
The resolution of inflammation is the primary domain of specialised pro-resolving mediators (SPMs), which include resolvins, protectins, and their forms synthesised under the influence of aspirin and the maresins. The role of these SPMs has been discussed by many authors in the literature, with particular reference to neuroinflammation and significant neurological disorders. This review discusses the role of G protein-coupled receptor 18 (GPR18), resolvin D2 (RvD2) activity, and the GPR18-RvD2 signalling axis, as well as the role of small molecule ligands of GPR18 in inflammation in various health disorders (brain injuries, neuropathic pain, neurodegenerative/cardiometabolic/cardiovascular/gastrointestinal diseases, peritonitis, periodontitis, asthma and lung inflammation, Duchenne muscular dystrophy, SARS-CoV-2-induced inflammation, and placenta disorders...
March 12, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542812/the-relationship-between-post-traumatic-stress-disorder-due-to-brain-injury-and-glutamate-intake-a-systematic-review
#26
REVIEW
Benjamin F Gruenbaum, Alexander Zlotnik, Anna Oleshko, Frederic Matalon, Honore N Shiyntum, Amit Frenkel, Matthew Boyko
There is a growing body of evidence that suggests a connection between traumatic brain injury (TBI) and subsequent post-traumatic stress disorder (PTSD). While the exact mechanism is unknown, we hypothesize that chronic glutamate neurotoxicity may play a role. The consumption of dietary glutamate is a modifiable factor influencing glutamate levels in the blood and, therefore, in the brain. In this systematic review, we explored the relationship between dietary glutamate and the development of post-TBI PTSD...
March 21, 2024: Nutrients
https://read.qxmd.com/read/38542520/association-of-blast-exposure-in-military-breaching-with-intestinal-permeability-blood-biomarkers-associated-with-leaky-gut
#27
JOURNAL ARTICLE
Qingkun Liu, Zhaoyu Wang, Shengnan Sun, Jeffrey Nemes, Lisa A Brenner, Andrew Hoisington, Maciej Skotak, Christina R LaValle, Yongchao Ge, Walter Carr, Fatemeh Haghighi
Injuries and subclinical effects from exposure to blasts are of significant concern in military operational settings, including tactical training, and are associated with self-reported concussion-like symptomology and physiological changes such as increased intestinal permeability (IP), which was investigated in this study. Time-series gene expression and IP biomarker data were generated from "breachers" exposed to controlled, low-level explosive blast during training. Samples from 30 male participants at pre-, post-, and follow-up blast exposure the next day were assayed via RNA-seq and ELISA...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542509/identification-of-an-intravenous-injectable-nk1-receptor-antagonist-for-use-in-traumatic-brain-injury
#28
JOURNAL ARTICLE
Robert Vink, Alan Nimmo
Traumatic brain injuries represent a leading cause of death and disability in the paediatric and adult populations. Moderate-to-severe injuries are associated with blood-brain barrier dysfunction, the development of cerebral oedema, and neuroinflammation. Antagonists of the tachykinin NK1 receptor have been proposed as potential agents for the post-injury treatment of TBI. We report on the identification of EUC-001 as a potential clinical candidate for development as a novel TBI therapy. EUC-001 is a selective NK1 antagonist with a high affinity for the human NK1 receptor (Ki 5...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542434/neuroprotective-effects-of-aucubin-against-cerebral-ischemia-and-ischemia-injury-through-the-inhibition-of-the-tlr4-nf-%C3%AE%C2%BAb-inflammatory-signaling-pathway-in-gerbils
#29
JOURNAL ARTICLE
Joon Ha Park, Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Il Jun Kang
Aucubin, an iridoid glycoside, possesses beneficial bioactivities in many diseases, but little is known about its neuroprotective effects and mechanisms in brain ischemia and reperfusion (IR) injury. This study evaluated whether aucubin exhibited neuroprotective effects against IR injury in the hippocampal CA1 region through anti-inflammatory activity in gerbils. Aucubin (10 mg/kg) was administered intraperitoneally once a day for one week prior to IR. Neuroprotective effects of aucubin were assessed by neuronal nuclei (NeuN) immunofluorescence and Floro-Jade C (FJC) histofluorescence...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542275/tbi-and-tau-loss-of-function-both-affect-na%C3%A3-ve-ethanol-sensitivity-in-drosophila
#30
JOURNAL ARTICLE
Valbona Hoxha, Gaurav Shrestha, Nayab Baloch, Sara Collevechio, Raegan Laszczyk, Gregg Roman
Traumatic brain injury (TBI) is associated with alcohol abuse and higher ethanol sensitivity later in life. Currently, it is poorly understood how ethanol sensitivity changes with time after TBI and whether there are sex-dependent differences in the relationship between TBI and ethanol sensitivity. This study uses the fruit fly Drosophila melanogaster to investigate how TBI affects alcohol sensitivity and whether the effects are sex-specific. Our results indicate that flies have a significantly higher sensitivity to the intoxicating levels of ethanol during the acute phase post-TBI, regardless of sex...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542274/post-traumatic-expressions-of-aromatase-b-glutamine-synthetase-and-cystathionine-beta-synthase-in-the-cerebellum-of-juvenile-chum-salmon-oncorhynchus-keta
#31
JOURNAL ARTICLE
Evgeniya V Pushchina, Mariya E Bykova, Anatoly A Varaksin
In adult fish, neurogenesis occurs in many areas of the brain, including the cerebellum, with the ratio of newly formed cells relative to the total number of brain cells being several orders of magnitude greater than in mammals. Our study aimed to compare the expressions of aromatase B (AroB), glutamine synthetase (GS), and cystathionine-beta-synthase (CBS) in the cerebellum of intact juvenile chum salmon, Oncorhynchus keta . To identify the dynamics that determine the involvement of AroB, GS, and CBS in the cellular mechanisms of regeneration, we performed a comprehensive assessment of the expressions of these molecular markers during a long-term primary traumatic brain injury (TBI) and after a repeated acute TBI to the cerebellum of O...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542250/exposure-to-non-steady-state-oxygen-is-reflected-in-changes-to-arterial-blood-gas-values-prefrontal-cortical-activity-and-systemic-cytokine-levels
#32
JOURNAL ARTICLE
Elizabeth G Damato, Joseph S Piktel, Seunghee P Margevicius, Seth J Fillioe, Lily K Norton, Alireza Abdollahifar, Kingman P Strohl, David S Burch, Michael J Decker
Onboard oxygen-generating systems (OBOGSs) provide increased inspired oxygen (Fi O2 ) to mitigate the risk of neurologic injury in high altitude aviators. OBOGSs can deliver highly variable oxygen concentrations oscillating around a predetermined Fi O2 set point, even when the aircraft cabin altitude is relatively stable. Steady-state exposure to 100% Fi O2 evokes neurovascular vasoconstriction, diminished cerebral perfusion, and altered electroencephalographic activity. Whether non-steady-state Fi O2 exposure leads to similar outcomes is unknown...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542064/-trans-and-cis-phosphorylated-tau-protein-new-pieces-of-the-puzzle-in-the-development-of-neurofibrillary-tangles-in-post-ischemic-brain-neurodegeneration-of-the-alzheimer-s-disease-like-type
#33
JOURNAL ARTICLE
Ryszard Pluta, Stanisław J Czuczwar
Recent evidence indicates that experimental brain ischemia leads to dementia with an Alzheimer's disease-like type phenotype and genotype. Based on the above evidence, it was hypothesized that brain ischemia may contribute to the development of Alzheimer's disease. Brain ischemia and Alzheimer's disease are two diseases characterized by similar changes in the hippocampus that are closely related to memory impairment. Following brain ischemia in animals and humans, the presence of amyloid plaques in the extracellular space and intracellular neurofibrillary tangles was revealed...
March 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542010/feasibility-of-fluid-responsiveness-assessment-in-patients-at-risk-for-increased-intracranial-pressure
#34
JOURNAL ARTICLE
Aleksandar R Zivkovic, Aleko Kjaev, Silvia Schönenberger, Sandro M Krieg, Markus A Weigand, Jan-Oliver Neumann
Background: Effective fluid management is important for patients at risk of increased intracranial pressure (ICP). Maintaining constant cerebral perfusion represents a challenge, as both hypovolemia and fluid overload can severely impact patient outcomes. Fluid responsiveness tests, commonly used in critical care settings, are often deemed potentially hazardous for these patients due to the risk of disrupting cerebral perfusion. Methods: This single-center, prospective, clinical observational study enrolled 40 patients at risk for increased ICP, including those with acute brain injury...
March 20, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541945/may-spasticity-related-unpleasant-sensations-interfere-with-daily-activities-in-people-with-stroke-and-traumatic-brain-injury-secondary-analysis-from-the-cortox-study
#35
JOURNAL ARTICLE
Salvatore Facciorusso, Stefania Spina, Alessandro Picelli, Alessio Baricich, Franco Molteni, Andrea Santamato
Background/Objectives: This study examined the impact of spasticity-related unpleasant sensations (pain, heaviness, stiffness) on various domains of the International Classification of Functioning, Disability, and Health (ICF) and psychosocial well-being in individuals affected by stroke or traumatic brain injury (TBI). The primary aim is to explore how these sensations affect daily activities, participation, and overall quality of life, guided by the comprehensive framework of the ICF. Methods: Utilizing a secondary analysis of data from a cohort undergoing Botulinum toxin type-A treatment for spasticity post-stroke or TBI, we developed and administered an ad-hoc questionnaire focusing on ICF domains such as body function, activities and participation, and psychosocial aspects such as mood, relationship, social life, motivation, and sleep quality...
March 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541720/activation-of-a-rhythmic-lower-limb-movement-pattern-during-the-use-of-a-multimodal-brain-computer-interface-a-case-study-of-a-clinically-complete-spinal-cord-injury
#36
JOURNAL ARTICLE
Carla Pais-Vieira, José Gabriel Figueiredo, André Perrotta, Demétrio Matos, Mafalda Aguiar, Júlia Ramos, Márcia Gato, Tânia Poleri, Miguel Pais-Vieira
Brain-computer interfaces (BCIs) that integrate virtual reality with tactile feedback are increasingly relevant for neurorehabilitation in spinal cord injury (SCI). In our previous case study employing a BCI-based virtual reality neurorehabilitation protocol, a patient with complete T4 SCI experienced reduced pain and emergence of non-spastic lower limb movements after 10 sessions. However, it is still unclear whether these effects can be sustained, enhanced, and replicated, as well as the neural mechanisms that underlie them...
March 16, 2024: Life
https://read.qxmd.com/read/38541637/influence-of-alcohol-on-intracerebral-hemorrhage-from-oxidative-stress-to-glial-cell-activation
#37
REVIEW
Shaik Ismail Mohammed Thangameeran, Po-Kai Wang, Hock-Kean Liew, Cheng-Yoong Pang
The intricate relationship between alcohol consumption and intracerebral hemorrhage (ICH) presents a nuanced field of study, especially concerning the dose-dependent impact on secondary brain injury (SBI). Recognizing the established risks associated with heavy drinking, this review delves deeper into the less understood territories of low to moderate alcohol consumption. By systematically analyzing recent studies, we uncover critical insights into how varying alcohol intake levels modulate ICH risk through mechanisms such as microglial activation, oxidative stress, and the protective potential of polyphenols...
February 27, 2024: Life
https://read.qxmd.com/read/38541634/comparative-analysis-of-antithrombotic-therapy-outcomes-in-mild-traumatic-brain-injury-patients-a-focus-on-bleeding-risk-and-hospital-stay-duration
#38
JOURNAL ARTICLE
Antonio Desai, Dana Shiffer, Mauro Giordano, Alice Giotta Lucifero, Elena Generali, Francesco Reggiani, Marta Calatroni, Gabriele Savioli, Sabino Luzzi, Antonio Voza
BACKGROUND: Traumatic brain injury (TBI) in the elderly is a noteworthy pathology due to the exponential increase in population age, and the effects of antiplatelet and anticoagulation on patients' outcomes are still a matter of dispute. The aim of the present study was to evaluate the impact of various antithrombotic agents on patients with mild TBI, focusing on the risk of intracranial bleeding (ICH) and length of hospitalization (LOS). METHODS: A retrospective analysis was conducted, including patients with a diagnosis of TBI admitted to the Emergency Department between 2021 and 2022...
February 27, 2024: Life
https://read.qxmd.com/read/38541187/balloon-pulmonary-angioplasty-for-inoperable-chronic-thromboembolic-pulmonary-hypertension-insights-from-a-pilot-low-volume-centre-study-and-a-comparative-analysis-with-other-centres
#39
JOURNAL ARTICLE
Taida Ivanauskiene, Sigitas Cesna, Egle Grigoniene, Lina Gumbiene, Aurelija Daubaraite, Kaste Ivanauskaite, Sigita Glaveckaite
Background and Objectives : The aim of this study was to evaluate the effectiveness and safety of balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) in the Vilnius Pulmonary Hypertension (PH) Referral Centre and to provide a comparative analysis with other centres. Materials and Methods : This study included all BPA procedures performed between 2019 and 2024 in a single tertiary centre. Invasive haemodynamic parameters and clinical variables were assessed at baseline; at the end of invasive treatment; and at the conclusion of follow-up, an average of 8...
March 11, 2024: Medicina
https://read.qxmd.com/read/38541106/cognitive-impairment-following-mild-traumatic-brain-injury-mtbi-a-review
#40
REVIEW
Ioannis Mavroudis, Alin Ciobica, Andreea Cristina Bejenariu, Romeo Petru Dobrin, Mihai Apostu, Irina Dobrin, Ioana-Miruna Balmus
Background: Mild Traumatic Brain Injury (mTBI) has been increasingly recognized as a public health concern due to its prevalence and potential to induce long-term cognitive impairment. We aimed to consolidate this observation by focusing on findings of neuropsychological assessments, neuroimaging, risk factors, and potential strategies for intervention to prevent and treat mTBI-associated cognitive impairments. Methods: A thorough search of PubMed, PsycINFO, and Embase databases was performed for studies published until 2024...
February 24, 2024: Medicina
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