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https://www.readbyqxmd.com/read/28930990/application-of-an-amplitude-integrated-eeg-monitor-cerebral-function-monitor-to-neonates
#1
Nora Bruns, Susanne Blumenthal, Irmgard Meyer, Susanne Klose-Verschuur, Ursula Felderhoff-Müser, Hanna Müller
Amplitude-integrated EEG (aEEG) is an easily accessible technique to monitor the electrocortical activity in preterm and term infants in neonatal intensive care units (NICUs). This method was first used to monitor newborns after asphyxia, providing information about future neurological outcomes. The aEEG is also helpful to select newborns who benefit from cooling. The aEEG monitoring of preterm infants is becoming more widespread, as various studies have shown that neurodevelopmental outcome is related to early aEEG tracings...
September 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930574/food-addiction-a-common-neurobiological-mechanism-with-drug-abuse
#2
Elsa Lindgren, Kyle Gray, Gregg Miller, Ryan Tyler, Corinde E Wiers, Nora D Volkow, Gene-Jack Wang
Drugs and food both exert a rewarding effect through the firing of dopamine neurons in the ventral tegmental area, resulting in the release of dopamine into the nucleus accumbens and effects on the mesolimbic pathway. Here, we review the neuroimaging literature to consider the validity of food addiction and the common neurobiological mechanisms that overlap in food and drug addiction. This review paper focuses on findings from Positron Emission Tomography (PET), functional Magnetic Resonance Imaging (fMRI) and structural imaging studies, as well as evidence from neuroimaging studies of bariatric surgery and pharmacological interventions on obese individuals...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28927576/loss-of-microrna-7-regulation-leads-to-%C3%AE-synuclein-accumulation-and-dopaminergic-neuronal-loss-in%C3%A2-vivo
#3
Kirsty J McMillan, Tracey K Murray, Nora Bengoa-Vergniory, Oscar Cordero-Llana, Jane Cooper, Amy Buckley, Richard Wade-Martins, James B Uney, Michael J O'Neill, Liang F Wong, Maeve A Caldwell
Abnormal alpha-synuclein (α-synuclein) expression and aggregation is a key characteristic of Parkinson's disease (PD). However, the exact mechanism(s) linking α-synuclein to the other central feature of PD, dopaminergic neuron loss, remains unclear. Therefore, improved cell and in vivo models are needed to investigate the role of α-synuclein in dopaminergic neuron loss. MicroRNA-7 (miR-7) regulates α-synuclein expression by binding to the 3' UTR of the Synuclein Alpha Non A4 Component of Amyloid Precursor (SNCA) gene and inhibiting its translation...
August 31, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28926568/changing-hearts-and-minds-results-from-a-multi-country-gender-and-sexual-diversity-training
#4
Tonia Poteat, Chulwoo Park, Diego Solares, John K Williams, R Cameron Wolf, Noah Metheny, Andrea Vazzano, Juan Dent, Ashley Gibbs, Bareng Aletta Sanny Nonyane, Nora Toiv
Engaging key populations, including gender and sexual minorities, is essential to meeting global targets for reducing new HIV infections and improving the HIV continuum of care. Negative attitudes toward gender and sexual minorities serve as a barrier to political will and effective programming for HIV health services. The President's Emergency Plan for AIDS Relief (PEPFAR), established in 2003, provided Gender and Sexual Diversity Trainings for 2,825 participants including PEPFAR staff and program implementers, U...
2017: PloS One
https://www.readbyqxmd.com/read/28924421/a-64-year-old-man-with-an-unusual-conjunctival-cyst
#5
Seanna Grob, Daniel R Lefebvre, Nora Laver, Mary K Daly
No abstract text is available yet for this article.
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/28922120/motion-estimation-in-echocardiography-using-sparse-representation-and-dictionary-learning
#6
Nora Ouzir, Adrian Basarab, Herve Liebgott, Brahim Harbaoui, Jean-Yves Tourneret
This paper introduces a new method for cardiac motion estimation in 2D ultrasound images. The motion estimation problem is formulated as an energy minimization, whose data fidelity term is built using the assumption that the images are corrupted by multiplicative Rayleigh noise. In addition to a classical spatial smoothness constraint, the proposed method exploits the sparse properties of the cardiac motion to regularize the solution via an appropriate dictionary learning step. The proposed method is evaluated on one dataset with available ground-truth, including four sequences of highly realistic simulations...
September 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28921778/alcohol-e-help-study-protocol-for-a-web-based-self-help-program-to-reduce-alcohol-use-in-adults-with-drinking-patterns-considered-harmful-hazardous-or-suggestive-of-dependence-in-middle-income-countries
#7
Michael P Schaub, Marcela Tiburcio, Nora Martinez, Atul Ambekar, Yatan Pal Singh Balhara, Andreas Wenger, André Luiz Monezi Andrade, Dzianis Padruchny, Sergey Osipchik, Elise Gehring, Vladimir Poznyak, Dag Rekve, Maria Lucia Oliveira Souza-Formigoni
BACKGROUND AND AIMS: Given the scarcity of alcohol prevention and alcohol use disorder treatments in many low and middle-income countries, the World Health Organization launched an e-health portal on alcohol and health that includes a Web-based self-help program. This paper presents the protocol for a multicenter randomised controlled trial (RCT) to test the efficacy of the Internet-based self-help intervention to reduce alcohol use. DESIGN: Two-arm RCT with follow-up 6 months after randomisation...
September 17, 2017: Addiction
https://www.readbyqxmd.com/read/28921719/inflammation-alters-ampa-stimulated-calcium-responses-in-dorsal-striatal-d2-but-not-d1-spiny-projection-neurons
#8
Carissa D Winland, Nora Welsh, Alberto Sepulveda-Rodriguez, Stefano Vicini, Kathleen A Maguire-Zeiss
Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of AMPARs. The preferential trafficking of calcium-permeable versus impermeable AMPARs can result in disruptions of [Ca(2+) ]i and alter cellular functions. In striatal neurodegenerative diseases, changes in [Ca(2+) ]i and L-type voltage-gated calcium channels (VGCCs) have been reported. Therefore, the present study sought to determine whether a proinflammatory environment alters AMPA-stimulated [Ca(2+) ]i through calcium-permeable AMPARs and/or L-type VGCCs in dopamine-2 and dopamine-1 expressing striatal spiny projection neurons (D2 and D1 SPNs) in the dorsal striatum...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28919871/investigating-the-neural-correlates-of-emotion-cognition-interaction-using-an-affective-stroop-task
#9
Nora M Raschle, Lynn V Fehlbaum, Willeke M Menks, Felix Euler, Philipp Sterzer, Christina Stadler
The human brain has the capacity to integrate various sources of information and continuously adapts our behavior according to situational needs in order to allow a healthy functioning. Emotion-cognition interactions are a key example for such integrative processing. However, the neuronal correlates investigating the effects of emotion on cognition remain to be explored and replication studies are needed. Previous neuroimaging studies have indicated an involvement of emotion and cognition related brain structures including parietal and prefrontal cortices and limbic brain regions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28919150/in-vitro-anti-tuberculosis-activity-of-azole-drugs-against-mycobacterium-tuberculosis-clinical-isolates
#10
Belén R Imperiale, Ángel A Cataldi, Nora S Morcillo
BACKGROUND: Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at different stages and on latent/dormant bacilli are urgently required to avoid endogenous reactivations and to be part of treatments of multi- and extensively-drug resistant tuberculosis (M/XDR-TB)...
September 14, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28916712/identification-of-new-channels-by-systematic-analysis-of-the-mitochondrial-outer-membrane
#11
Vivien Krüger, Thomas Becker, Lars Becker, Malayko Montilla-Martinez, Lars Ellenrieder, F-Nora Vögtle, Helmut E Meyer, Michael T Ryan, Nils Wiedemann, Bettina Warscheid, Nikolaus Pfanner, Richard Wagner, Chris Meisinger
The mitochondrial outer membrane is essential for communication between mitochondria and the rest of the cell and facilitates the transport of metabolites, ions, and proteins. All mitochondrial outer membrane channels known to date are β-barrel membrane proteins, including the abundant voltage-dependent anion channel and the cation-preferring protein-conducting channels Tom40, Sam50, and Mdm10. We analyzed outer membrane fractions of yeast mitochondria and identified four new channel activities: two anion-preferring channels and two cation-preferring channels...
September 15, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28914373/the-therapeutic-effect-of-probiotics-on-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-control-trials
#12
Abdelrahman Tarek Mohammed, Mohammed Khattab, Ali Mahmoud Ahmed, Tarek Turk, Nora Sakr, Adham M Khalil, Mohamed Abdelhalim, Bisher Sawaf, Kenji Hirayama, Nguyen Tien Huy
Rheumatoid arthritis is an autoimmune disease in which probiotics appears to have an immune modulating action along with decreased inflammatory process. Therefore, we aim to investigate the efficacy of probiotics as an adjuvant therapy for rheumatoid arthritis. A comprehensive literature search was performed using nine databases including PubMed and Web of Science. Interesting data was extracted and meta-analyzed. We assessed the risk of bias using Cochrane Collaboration's tool. The protocol was registered in PROSPERO (CRD 42016036769)...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28913915/home-use-remotely-supervised-and-remotely-controlled-transcranial-direct-current-stimulation-a-systematic-review-of-the-available-evidence
#13
REVIEW
Ulrich Palm, Ulrike Kumpf, Nora Behler, Linda Wulf, Beatrice Kirsch, Jana Wörsching, Daniel Keeser, Alkomiet Hasan, Frank Padberg
OBJECTIVES: Transcranial direct current stimulation (tDCS) is gaining growing importance in the treatment of neurological and psychiatric disorders and is currently investigated for home-based and remotely supervised applications. METHODS: Here, we systematically review the available evidence from a database search (PubMed, ICTRP, clinicaltrials.gov) from January 2000 to May 2017. RESULTS: We detected 22 original research papers, trial protocols or trial registrations dealing with tDCS as an add-on intervention to cognitive or physiotherapeutic intervention...
September 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28913582/glyphosate-ab-sorption-by-shoots-and-rhizomes-of-native-versus-hybrid-cattail-typha
#14
Tianye Zheng, Nora B Sutton, Pim de Jager, Richard Grosshans, Sirajum Munira, Annemieke Farenhorst
Wetlands in the Prairie Pothole Region of North America are integrated with farmland and contain mixtures of herbicide contaminants. Passive nonfacilitated diffusion is how most herbicides can move across plant membranes, making this perhaps an important process by which herbicide contaminants are absorbed by wetland vegetation. Prairie wetlands are dominated by native cattail (Typha latifolia) and hybrid cattail (Typha x glauca). The objective of this batch equilibrium study was to compare glyphosate absorption by the shoots and rhizomes of native versus hybrid cattails...
September 14, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28911688/curcumin-inhibits-adenosine-deaminase-and-arginase-activities-in-cadmium-induced-renal-toxicity-in-rat-kidney
#15
Ayodele Jacob Akinyemi, Nora Onyebueke, Opeyemi Ayodeji Faboya, Sunday Amos Onikanni, Adewale Fadaka, Israel Olayide
In this study, the effect of enzymes involved in degradation of renal adenosine and l-arginine was investigated in rats exposed to cadmium (Cd) and treated with curcumin, the principal active phytochemical in turmeric rhizome. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, saline/curcumin 25 mg/kg, Cd/vehicle, Cd/curcumin 12.5 mg/kg, and Cd/curcumin 25 mg/kg. The results of this study revealed that the activities of renal adenosine deaminase and arginase were significantly increased in Cd-treated rats when compared with the control (p < 0...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911207/trans-ethnic-meta-regression-of-genome-wide-association-studies-accounting-for-ancestry-increases-power-for-discovery-and-improves-fine-mapping-resolution
#16
Reedik Mägi, Momoko Horikoshi, Tamar Sofer, Anubha Mahajan, Hidetoshi Kitajima, Nora Franceschini, Mark I McCarthy, Andrew P Morris
Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse populations can increase power to detect complex trait loci when the underlying causal variants are shared between ancestry groups. However, heterogeneity in allelic effects between GWAS at these loci can occur that is correlated with ancestry. Here, a novel approach is presented to detect SNP association and quantify the extent of heterogeneity in allelic effects that is correlated with ancestry. We employ trans-ethnic meta-regression to model allelic effects as a function of axes of genetic variation, derived from a matrix of mean pairwise allele frequency differences between GWAS, and implemented in the MR-MEGA software...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28905289/lymph-node-positive-prostate-cancer-after-robotic-prostatectomy-and-extended-pelvic-lymphadenectomy
#17
Avinash Chenam, Jaspreet S Parihar, Nora Ruel, Sumanta Pal, Yvonne Avila, Jonathan Yamzon, Clayton Lau, Bertram Yuh
Optimal management of node-positive prostate cancer patients after prostatectomy remains a challenge. We evaluated clinically localized patients who demonstrated node positivity and identified predictors for secondary treatment. From 2010 to 2015, clinically localized prostate cancer patients who underwent robot prostatectomy with extended lymphadenectomy and node-positive disease on pathologic analysis were identified. Clinical N1, M1 or salvage cases were excluded. Patients were stratified based on secondary treatments...
September 13, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28904264/zoonotic-potential-and-antibiotic-resistance-of-escherichia-coli-in-neonatal-calves-in-uruguay
#18
Ana Umpiérrez, Inés Bado, Martín Oliver, Sofía Acquistapace, Analía Etcheverría, Nora Lía Padola, Rafael Vignoli, Pablo Zunino
Escherichia coli is one of the main etiological agents of neonatal calf diarrhea (NCD). The objective of this study was to assess the presence of virulence genes, genetic diversity, and antibiotic resistance mechanisms in E. coli associated with NCD in Uruguay. PCR was used to assess the presence of intimin, Shiga-like toxin, and stable and labile enterotoxin genes. Resistance to fluoroquinolones and oxyimino-cephalosporins was estimated on Müller-Hinton agar plates. Further antibiotic disc-diffusion tests were performed to assess bacterial multi-resistance...
September 12, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28901804/histological-and-antimicrobial-study-of-ononis-arvensis-l
#19
Tünde Dénes, Sámuel Gergely Bartha, Mónika Kerényi, Erzsébet Varga, Viktória Lilla Balázs, Rita Csepregi, Nóra Papp
In this study field restharrow (Ononis arvensis) was investigated for histological and antimicrobial features. The aerial part and the root were embedded in synthetic resin and investigated following sectioning by a rotation microtome. The antimicrobial activity and minimum inhibitory concentration of the solvent fractions of the aerial part were studied against four bacterial strains and one fungus. According to histology, the root covered by rhizodermis contains contiguous vascular elements, which are surrounded by sclerenchyma cells...
September 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28900426/interleukin-il-18-binding-protein-deficiency-disrupts-natural-killer-cell-maturation-and-diminishes-circulating-il-18
#20
Robert Z Harms, Austin J Creer, Kristina M Lorenzo-Arteaga, Katie R Ostlund, Nora E Sarvetnick
The cytokine interleukin (IL)-18 is a crucial amplifier of natural killer (NK) cell function. IL-18 signaling is regulated by the inhibitory effects of IL-18 binding protein (IL-18BP). Using mice deficient in IL-18BP (IL-18BPKO), we investigated the impact of mismanaged IL-18 signaling on NK cells. We found an overall reduced abundance of splenic NK cells in the absence of IL-18BP. Closer examination of NK cell subsets in spleen and bone marrow using CD27 and CD11b expression revealed that immature NK cells were increased in abundance, while the mature population of NK cells was reduced...
2017: Frontiers in Immunology
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