Zachariah Raouf, Steve N Steinway, Daniel Scheese, Carla M Lopez, Johannes W Duess, Koichi Tsuboi, Maame Sampah, Daphne Klerk, Mahmoud El Baassiri, Hannah Moore, Cody Tragesser, Thomas Prindle, Sanxia Wang, Menghan Wang, Hee-Seong Jang, William B Fulton, Chhinder P Sodhi, David J Hackam
BACKGROUND & AIMS: The abdominal discomfort experienced by patients with colitis may be attributable in part to the presence of small intestinal dysmotility, yet mechanisms linking colonic inflammation with small bowel motility remain largely unexplored. We hypothesize that colitis results in small intestinal hypomotility due to a loss of enteroendocrine cells (EECs) within the small intestine that can be rescued using serotonergic-modulating agents. METHODS: Male C57BL/6J mice, as well as mice that over-express (EECOVER ) or lack (EECDEL ) NeuroD1+ enteroendocrine cells, were exposed to DSS-colitis (2...
March 2, 2024: Cellular and Molecular Gastroenterology and Hepatology