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Serotonin transporter

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https://www.readbyqxmd.com/read/29781098/pet-imaging-of-the-influence-of-physiological-and-pathological-%C3%AE-synuclein-on-dopaminergic-and-serotonergic-neurotransmission-in-mouse-models
#1
Elise Levigoureux, Caroline Bouillot, Thierry Baron, Luc Zimmer, Sophie Lancelot
AIMS: Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of neurodegenerative synucleinopathies. This in vivo study explored glucose metabolism and dopaminergic and serotoninergic neurotransmission in KO α-syn, wild-type mice and an accelerated murine model of synucleinopathy (M83). METHODS: MicroPET acquisitions were performed in all animals aged 5-6 months using five radiotracers exploring brain glucose metabolism ([18 F]FDG), dopamine neurotransmission ([11 C]raclopride, [11 C]PE2I) and serotonin neurotransmission ([18 F]MPPF, [11 C]DASB)...
May 20, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29774458/effects-of-rs591323-on-serotonin-transporter-availability-in-healthy-male-subjects
#2
Kyoungjune Pak, Hyun-Yeol Nam, Seunghyeon Shin, Keunyoung Kim, Myung Jun Lee, Eun-Joo Kim, Jae Meen Lee, Seong-Jang Kim, In Joo Kim
OBJECTIVES: We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls. METHODS: The study population consisted of healthy controls with screening 123 I-FP-CIT single-photon emission computed tomography. Specific binding of 123 I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons...
May 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29763575/social-isolation-reduces-serotonergic-fiber-density-in-the-inferior-colliculus-of-female-but-not-male-mice
#3
Sarah M Keesom, Mitchell D Morningstar, Rebecca Sandlain, Bradley M Wise, Laura M Hurley
Early-life experiences, including maternal deprivation and social isolation during adolescence, have a profound influence on a range of adult social behaviors. Post-weaning social isolation in rodents influences behavior in part through the alteration of neuromodulatory systems, including the serotonergic system. Of significance to social behavior, the serotonergic system richly innervates brain areas involved in vocal communication, including the auditory system. However, the influence of isolation on serotonergic input to the auditory system remains underexplored...
May 12, 2018: Brain Research
https://www.readbyqxmd.com/read/29762664/behavioral-and-serotonergic-changes-in-the-frontal-cortex-following-methamphetamine-self-administration
#4
Lisa M McFadden, Rebecca Cordie, Tamee Livermont, Andrew Johansen
Background: Methamphetamine (METH) use is associated with a variety of negative health outcomes including psychosis. The frontal cortex serotonin (5-HT)-2 receptors are thought to contribute to psychosis-like behaviors. This study investigated changes in serotonergic markers in the frontal cortex following METH self-administration and hallucinogenic drug-induced behavior. Methods: Consistent with previously published studies, freely-cycling male and female rats were allowed to self-administer METH (Males: 0...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29760654/failure-to-replicate-the-association-between-fractional-anisotropy-and-the-serotonin-transporter-gene-5-httlpr-rs25531
#5
Tim Klucken, Isabell Tapia León, Carlo Blecker, Onno Kruse, Tobias Stalder, Rudolf Stark
Recent work underlines the importance of alterations in white matter (e.g., measured by fractional anisotropy (FA)) as a neural vulnerability marker for psychiatric disorders. In this context, the uncinate fasciculus (UF), which connects the limbic system with prefrontal areas, has repeatedly been linked to psychiatric disorders, fear processing, and anxiety-related traits. Individual differences in FA may partly be genetically determined. Variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) is a particularly promising candidate in this context, which has been linked to psychiatric disorders as well as to limbic and prefrontal reactivity...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29738736/organic-cation-transporter-3-a-cellular-mechanism-underlying-rapid-non-genomic-glucocorticoid-regulation-of-monoaminergic-neurotransmission-physiology-and-behavior
#6
REVIEW
Paul J Gasser, Christopher A Lowry
Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses. In addition to these classical genomic effects, corticosteroid hormones also exert rapid actions on physiology and behavior through a variety of non-genomic mechanisms, some of which involve GR or MR, and others of which are independent of these receptors. One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2 " transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine...
May 5, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29738009/serotonin-and-serotonin-transporter-levels-in-autistic-children
#7
Haidar A Abdulamir, Omar F Abdul-Rasheed, Emad A Abdulghani
OBJECTIVES: To assess the possible correlation between serotonin and serotonin transporter (SERT) with the autism severity and investigate the association between these parameters in autistic children to assess their possible role for diagnosis of autism severity. METHODS: A comparative cross-sectional study was carried out in the Chemistry and Biochemistry Department, College of Medicine, Al-Nahrain University, Baghdad, Iraq while the samples were taken from 60 male autistic children recruited to the Department of Pediatrics at Al-Sader Hospital, Baghdad, Iraq between November 2014 amd April 2015...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29733742/are-ecstasy-induced-serotonergic-alterations-overestimated-for-the-majority-of-users
#8
Balázs Szigeti, Adam R Winstock, David Erritzoe, Larissa J Maier
BACKGROUND: Neuroimaging studies imply that the regular use of ±3,4-methylenedioxymethamphetamine (MDMA), the major constituent of ecstasy pills, alters the brain's serotonergic system in a dose-dependent manner. However, the relevance of these findings remains unclear due to limited knowledge about the ecstasy/MDMA use pattern of real-life users. AIMS: We examined the representativeness of ecstasy users enrolled in neuroimaging studies by comparing their ecstasy use habits with the use patterns of a large, international sample...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29725904/chronic-mild-stress-alters-kynurenine-pathways-changing-the-glutamate-neurotransmission-in-frontal-cortex-of-rats
#9
David Martín-Hernández, Hiram Tendilla-Beltrán, José L M Madrigal, Borja García-Bueno, Juan C Leza, Javier R Caso
Immune stimulation might be involved in the pathophysiology of major depressive disorder (MDD). This stimulation induces indoleamine 2,3-dioxygenase (IDO), an enzyme that reduces the tryptophan bioavailability to synthesize serotonin. IDO products, kynurenine metabolites, exert neurotoxic/neuroprotective actions through glutamate receptors. Thus, we study elements of these pathways linked to kynurenine metabolite activity examining whether antidepressants (ADs) can modulate them. Male Wistar rats were exposed to chronic mild stress (CMS), and some of them were treated with ADs...
May 3, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29723540/tnf%C3%AE-dependent-anhedonia-and-upregulation-of-hippocampal-serotonin-transporter-activity-in-a-mouse-model-of-collagen-induced-arthritis
#10
Eric Brown, Conor J Mc Veigh, Leilani Santos, Martina Gogarty, Heidi Kaastrup Müller, Betina Elfving, David J Brayden, Jana Haase
The serotonin transporter (SERT) facilitates high affinity reuptake of 5-HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked immune system activation to depression as well as to altered serotonin transporter activity. Advancing previous studies, which have mainly focussed on acute effects of immune system activation, in this study we used collagen-induced arthritis (CIA) in mice as a model of chronic inflammatory disease, to investigate the effect of prolonged inflammation on brain SERT function and behaviour...
April 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29719628/novel-water-soluble-lignin-derivative-bp-cx-1-identification-of-components-and-screening-of-potential-targets-in-silico-and-in-vitro
#11
Elena I Fedoros, Alexey A Orlov, Alexander Zherebker, Ekaterina A Gubareva, Mikhail A Maydin, Andrey I Konstantinov, Konstantin A Krasnov, Ruben N Karapetian, Ekaterina I Izotova, Sergey E Pigarev, Andrey V Panchenko, Margarita L Tyndyk, Dmitry I Osolodkin, Evgeny N Nikolaev, Irina V Perminova, Vladimir N Anisimov
Identification of molecular targets and mechanism of action is always a challenge, in particular - for natural compounds due to inherent chemical complexity. BP-Cx-1 is a water-soluble modification of hydrolyzed lignin used as the platform for a portfolio of innovative pharmacological products aimed for therapy and supportive care of oncological patients. The present study describes a new approach, which combines in vitro screening of potential molecular targets for BP-Cx-1 using Diversity Profile - P9 panel by Eurofins Cerep (France) with a search of possible active components in silico in ChEMBL - manually curated chemical database of bioactive molecules with drug-like properties...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713996/the-effects-of-exposure-to-mephedrone-during-adolescence-on-brain-neurotransmission-and-neurotoxicity-in-adult-rats
#12
Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Anna Górska, Joanna Rzemieniec, Agnieszka Wnuk, Adam Wojtas, Grzegorz Kreiner, Małgorzata Kajta, Krystyna Gołembiowska
According to the European Drug Report (2016), the use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in the last years. Studies in humans indicate that psychostimulant drug use in adolescence increases risk of drug abuse in adulthood. Mephedrone by its interaction with transporters for dopamine (DAT) and serotonin (SERT) stimulates their release to the synaptic cleft. In animal studies, high repeated doses of mephedrone given to adolescent but not adult mice or rats induced toxic changes in 5-hydroxytryptamine (5-HT) neurons...
April 30, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29712944/appetitive-and-reactive-aggression-are-differentially-associated-with-the-stin2-genetic-variant-in-the-serotonin-transporter-gene
#13
Sian Megan Joanna Hemmings, Khethelo Xulu, Jessica Sommer, Martina Hinsberger, Stefanie Malan-Muller, Gerard Tromp, Thomas Elbert, Roland Weierstall, Soraya Seedat
Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290)...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29697951/effects-of-n-alkyl-4-methylamphetamine-optical-isomers-on-plasma-membrane-monoamine-transporters-and-abuse-related-behavior
#14
Umberto Maria Battisti, Ramsey Sitta, Alan Harris, Farhana Sakloth, Donna Walther, Iwona Ruchala, Sidney Negus, Michael H Baumann, Richard A Glennon, Jose Miguel Eltit
4-Methylamphetamine (4-MA) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT), thereby causing non-exocytotic release of monoamine transmitters via reverse transport. Prior studies show that increasing the N-alkyl chain length of 4-MA converts the agent from a transportable substrate (i.e., releaser) at DAT and NET to a non-transported blocker at these sites. Here we studied the effects of stereoisomers of N-methyl-, N-ethyl-, and N-n-propyl 4-MA on monoamine transporters and abuse-related behavior in rats...
April 26, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29697048/a-label-free-approach-to-detect-ligand-binding-to-cell-surface-proteins-in-real-time
#15
Verena Burtscher, Matej Hotka, Yang Li, Michael Freissmuth, Walter Sandtner
Electrophysiological recordings allow for monitoring the operation of proteins with high temporal resolution down to the single molecule level. This technique has been exploited to track either ion flow arising from channel opening or the synchronized movement of charged residues and/or ions within the membrane electric field. Here, we describe a novel type of current by using the serotonin transporter (SERT) as a model. We examined transient currents elicited on rapid application of specific SERT inhibitors...
April 26, 2018: ELife
https://www.readbyqxmd.com/read/29692741/impulsive-internet-game-play-is-associated-with-increased-functional-connectivity-between-the-default-mode-and-salience-networks-in-depressed-patients-with-short-allele-of-serotonin-transporter-gene
#16
Ji Sun Hong, Sun Mi Kim, Sujin Bae, Doug Hyun Han
Problematic Internet game play is often accompanied by major depressive disorder (MDD). Depression seems to be closely related to altered functional connectivity (FC) within (and between) the default mode network (DMN) and salience network. In addition, serotonergic neurotransmission may regulate the symptoms of depression, including impulsivity, potentially by modulating the DMN. We hypothesized that altered connectivity between the DMN and salience network could mediate an association between the 5HTTLPR genotype and impulsivity in patients with depression...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29688474/increase-in-processing-factors-is-involved-in-skewed-microrna-expression-in-patients-with-ulcerative-colitis-who-develop-small-intestine-inflammation-after-pouch-surgery
#17
Hadas Sherman Horev, Keren M Rabinowitz, Hofit Elad, Revital Barkan, Shay Ben-Shachar, Metsada Pasmanik Chor, Iris Dotan
Background: A large-scale increase in microRNA (miRNA) expression was observed in patients with ulcerative colitis who underwent pouch surgery and developed inflammation of the pouch (pouchitis). In this study, we assessed miRNA expression in these patients and investigated how regulation of its expression changes in the setting of pouchitis. Methods: Autologous samples that included mucosal biopsies, peripheral blood cells, and plasma were collected from the patients...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29683385/polymorphism-in-the-serotonin-transporter-gene-polymorphisms-5-httlpr-modifies-the-association-between-significant-life-events-and-depression-in-people-with-multiple-sclerosis
#18
Alice Saul, Bruce Taylor, Steve Simpson, Anne-Louise Ponsonby, Leigh Blizzard, Terence Dwyer, Brendan McMorran, Brenda Wood, Ingrid Af van der Mei
BACKGROUND: In the general population, variation in the serotonin-transporter-linked polymorphic region ( 5-HTTLPR) has been shown to modify the association between stressful events and depression/anxiety. This has not been examined in people with multiple sclerosis (MS). OBJECTIVE: We examined the interaction between significant life events (SLE), 5-HTTLPR and depression/anxiety. METHODS: A population-based longitudinal cohort of 198 people with MS was followed biannually for 2...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29681988/nervous-system-development-in-the-pacific-oyster-crassostrea-gigas-mollusca-bivalvia
#19
Olga V Yurchenko, Olga I Skiteva, Elena E Voronezhskaya, Vyacheslav A Dyachuk
Background: Bivalves comprise a large, highly diverse taxon of invertebrate species. Developmental studies of neurogenesis among species of Bivalvia are limited. Due to a lack of neurogenesis information, it is difficult to infer a ground pattern for Bivalvia. To provide more comprehensive morphogenetic data on bivalve molluscs and relationships among molluscan clades, we investigated neurogenesis in the Pacific oyster, Crassostrea gigas , from the appearance of the first sensory cells to the formation of the larval ganglionic nervous system by co-immunocytochemistry of the neuronal markers FMRFamide or 5-HT and vesicular acetylcholine transporter (VAChT)...
2018: Frontiers in Zoology
https://www.readbyqxmd.com/read/29680514/brain-blood-cerebrospinal-fluid-and-serum-biomarkers-in-schizophrenia
#20
REVIEW
Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeian
Over the last decade, finding a reliable biomarker for the early detection of schizophrenia (Scz) has been a topic of interest. The main goal of the current review is to provide a comprehensive view of the brain, blood, cerebrospinal fluid (CSF), and serum biomarkers of Scz disease. Imaging studies have demonstrated that the volumes of the corpus callosum, thalamus, hippocampal formation, subiculum, parahippocampal gyrus, superior temporal gyrus, prefrontal and orbitofrontal cortices, and amygdala-hippocampal complex were reduced in patients diagnosed with Scz...
April 13, 2018: Psychiatry Research
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