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https://www.readbyqxmd.com/read/28227920/in-vitro-evaluation-of-the-long-term-stability-of-pedot-pss-coated-microelectrodes-for-chronic-recording-and-electrical-stimulation-of-neurons
#1
A Schander, T Tesmann, S Strokov, H Stemmann, A K Kreiter, W Lang, A Schander, T Tesmann, S Strokov, H Stemmann, A K Kreiter, W Lang, A K Kreiter, W Lang, A Schander, H Stemmann, S Strokov
For the chronic application of neural prostheses long-term stable microelectrodes for electrical stimulation are essential. In recent years many developments were done to investigate different appropriate materials for these electrodes. One of these materials is the electrical conductive polymer PEDOT, which has low impedance and high charge injection capacity. However, the long-term stability of this polymer is still unclear. Thus this paper reports on the in-vitro evaluation of the long-term stability of PEDOT coated gold microelectrodes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227597/long-term-vital-sign-measurement-using-a-non-contact-vital-sign-sensor-inside-an-office-cubicle-setting
#2
T Hall, N A Malone, J Tsay, J Lopez, T Nguyen, R E Banister, D Y C Lie, T Hall, N A Malone, J Tsay, J Lopez, T Nguyen, R E Banister, D Y C Lie, T Hall, J Lopez, N A Malone, T Nguyen, J Tsay, D Y C Lie, R E Banister
Heart and respiration rates can be wirelessly measured by extracting the phase shift caused by the periodic displacement of a patient's chest wall. We have developed a phased-array Doppler-based non-contact vital sign (NCVS) sensor capable of long-term vital signs monitoring using an automatic patient tracking and movement detection algorithm. Our NCVS sensor achieves non-contact heart rate monitoring with accuracies of over 90% (i.e, within ±5 Beats-Per-Minute vs. a reference sensor) across a large number of data points collected over various days of the week inside a typical office cubicle setting at a distance of 1...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227444/novel-3d-coaxial-flow-focusing-nozzle-device-for-the-production-of-monodispersed-collagen-microspheres
#3
Sravani Jaligama, Po-Jung Huang, Jun Kameoka, Sravani Jaligama, Po-Jung Huang, Jun Kameoka, Jun Kameoka, Sravani Jaligama, Po-Jung Huang
We have developed a 3D coaxial flow-focusing nozzle device for the mass production of monodispersed collagen microspheres and chemically crosslinked them using EDC (1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide) and N-hydroxysuccinimide (NHS). The size of the microspheres was varied between 200 μm and 600 μm by adjusting the ratio of the flow rates of the dispersed and continuous phases. MDA231-GFP cells were attached to the surface of these particles and their viability was investigated. Because they are comprised of a natural biomaterial, these collagen microspheres will have numerous applications, including bone regeneration scaffolds for tissue engineering and analyses of cancer cell interactions in a 3D environment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227393/an-integrated-neuroprotective-intervention-for-brain-ischemia-validated-by-ecog-fpam
#4
Yu-Hang Liu, Lun-De Liao, Su Jing Chan, Aishwarya Bandla, Nitish V Thakor, Yu-Hang Liu, Lun-De Liao, Su Jing Chan, Aishwarya Bandla, Nitish V Thakor, Yu-Hang Liu, Aishwarya Bandla, Nitish V Thakor, Su Jing Chan, Lun De Liao
Brain ischemia is a neurological deficit caused by a reduction in the blood supply to tissue, and one of the leading causes of disability in the world. Currently, the most well-known therapeutic agent for ischemia recovery is recombinant tissue plasminogen activator (rtPA), but it is viable for only a small portion (approximately 3.6%) of ischemic patients and may cause side effects such as tissue damage. Thus, introducing a new therapeutic concept for ischemia, we proposed an integrated intervention combining global and focal stimulations in this article...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227106/epileptic-seizure-onset-correlates-with-long-term-eeg-functional-brain-network-properties
#5
Maria Anastasiadou, Avgis Hadjipapas, Manolis Christodoulakis, Eleftherios S Papathanasiou, Savvas S Papacostas, Georgios D Mitsis, Maria Anastasiadou, Avgis Hadjipapas, Manolis Christodoulakis, Eleftherios S Papathanasiou, Savvas S Papacostas, Georgios D Mitsis, Maria Anastasiadou, Avgis Hadjipapas, Manolis Christodoulakis, Savvas S Papacostas, Eleftherios S Papathanasiou, Georgios D Mitsis
We investigated the correlation of epileptic seizure onset times with long term EEG functional brain network properties. To do so, we constructed binary functional brain networks from long-term, multichannel electroencephalographic data recorded from nine patients with epilepsy. The corresponding network properties were quantified using the average network degree. It was found that the network degree (as well as other network properties such as the network efficiency and clustering coefficient) exhibited large fluctuations over time; however, it also exhibited specific periodic temporal structure over different time scales (1...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226872/multimodel-quantitative-analysis-of-somatosensory-evoked-potentials-after-cardiac-arrest-with-graded-hypothermia
#6
Leanne Moon Young, Rishabh Choudhary, Xiaofeng Jia, Leanne Moon Young, Rishabh Choudhary, Xiaofeng Jia, Xiaofeng Jia, Leanne Moon Young, Rishabh Choudhary
Cardiac arrest (CA) is one of the most prominent causes of morbidity and mortality in adults. Therapeutic hypothermia (TH) is a recommended treatment to improve survival and functional outcome following CA, however, it is unclear what degree of TH is most beneficial. It has been suggested that TH of 33°C provides no survival or outcome benefits over TH of 36°C. Additionally, there is a lack of verified objective quantitative prognostic tools for comatose CA patients under TH. In this study, we calculated three quantitative markers of somatosensory evoked potentials (SSEP) to examine their potential to track recovery in the early period following CA under graded TH...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226724/investigation-of-driving-forces-of-cerebrospinal-fluid-motion-by-power-and-frequency-mapping-based-on-asynchronous-phase-contrast-technique
#7
Saeko Sunohara, Satoshi Yatsushiro, Ken Takizawa, Mitsunori Matsumae, Nao Kajihara, Kagayaki Kuroda, Saeko Sunohara, Satoshi Yatsushiro, Ken Takizawa, Mitsunori Matsumae, Nao Kajihara, Kagayaki Kuroda, Ken Takizawa, Saeko Sunohara, Kagayaki Kuroda, Nao Kajihara, Mitsunori Matsumae, Satoshi Yatsushiro
To classify the cardiac- and respiratory-driven cerebrospinal fluid (CSF) motions, asynchronous 2D phase contrast (PC) of magnetic resonance imaging (MRI) with 217 ms time resolution in conjunction with power and frequency mapping was performed for 7 healthy subjects under respiration guidance. In the frequency domain, the cardiac-driven motion was at around 1.29±0.21 Hz and respiratory-driven motion was at 0.16±0.01 Hz under 6 sec respiratory cycle. Two different techniques were proposed for characterizing the motions; one was power-map (P-map) depicting integrated power spectrum in a selected band, and the other was frequency-map (F-map) delineating the frequency of maximum peak in power spectral density (PSD)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226721/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#8
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan, Stuart Norris, Brett Cowan, Pau Medrano-Gracia, Kathleen Gilbert, Mark Webster, Alistair Young, Susann Beier, John Cater, John Ormiston
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226660/identifying-stereotypic-evolving-micro-scale-seizures-sems-in-the-hypoxic-ischemic-eeg-of-the-pre-term-fetal-sheep-with-a-wavelet-type-ii-fuzzy-classifier
#9
Hamid Abbasi, Laura Bennet, Alistair J Gunn, Charles P Unsworth, Hamid Abbasi, Laura Bennet, Alistair J Gunn, Charles P Unsworth, Charles P Unsworth, Laura Bennet, Hamid Abbasi, Alistair J Gunn
Perinatal hypoxic-ischemic encephalopathy (HIE) around the time of birth due to lack of oxygen can lead to debilitating neurological conditions such as epilepsy and cerebral palsy. Experimental data have shown that brain injury evolves over time, but during the first 6-8 hours after HIE the brain has recovered oxidative metabolism in a latent phase, and brain injury is reversible. Treatments such as therapeutic cerebral hypothermia (brain cooling) are effective when started during the latent phase, and continued for several days...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226593/dynamic-cerebral-autoregulation-in-young-athletes-following-concussion
#10
Kyriaki Kostoglou, Alexander D Wright, Jonathan D Smirl, Kelsey Bryk, Paul van Donkelaar, Georgios D Mitsis, Kyriaki Kostoglou, Alexander D Wright, Jonathan D Smirl, Kelsey Bryk, Paul van Donkelaar, Georgios D Mitsis, Paul van Donkelaar, Alexander D Wright, Kyriaki Kostoglou, Jonathan D Smirl, Kelsey Bryk, Georgios D Mitsis
The purpose of this study was to examine cerebral autoregulation (CA) in young athletes experiencing concussion. The subjects were monitored and repeatedly tested 72 hours, 2 weeks and 1 month post-injury. Mean arterial blood pressure (MABP), end-tidal partial pressure of carbon dioxide (PETCO2) and cerebral blood flow velocity (CBFV) in the middle and posterior cerebral arteries were monitored during mental activation paradigms. In order to characterize CA we employed autoregressive models with exogenous inputs (ARX) and impulse response models based on the Laguerre expansion technique (LET)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226493/towards-an-unsupervised-device-for-the-diagnosis-of-childhood-pneumonia-in-low-resource-settings-automatic-segmentation-of-respiratory-sounds
#11
J Sola, F Braun, E Muntane, C Verjus, M Bertschi, F Hugon, S Manzano, M Benissa, A Gervaix, J Sola, F Braun, E Muntane, C Verjus, M Bertschi, F Hugon, S Manzano, M Benissa, A Gervaix, F Hugon, C Verjus, A Gervaix, S Manzano, M Bertschi, E Muntane, M Benissa, J Sola, F Braun
Pneumonia remains the worldwide leading cause of children mortality under the age of five, with every year 1.4 million deaths. Unfortunately, in low resource settings, very limited diagnostic support aids are provided to point-of-care practitioners. Current UNICEF/WHO case management algorithm relies on the use of a chronometer to manually count breath rates on pediatric patients: there is thus a major need for more sophisticated tools to diagnose pneumonia that increase sensitivity and specificity of breath-rate-based algorithms...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226430/postural-flexibility-during-quiet-standing-in-healthy-elderly-and-patients-with-parkinson-s-disease
#12
Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura, Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura, Kei Fukada, Naoya Yoshikawa, Tomohisa Yamamoto, Takuyuki Endo, Kunihiko Nomura, Taishin Nomura, Kazuyuki Matsuda, Ken Kiyono, Takao Tanahashi, Saburo Sakoda, Yasuyuki Suzuki
Postural instability is one of the predominant symptoms of Parkinson's disease (PD). Despite its significant impact on the deterioration in quality of life in PD patients, mechanistic causes of the instability have not been clarified. Joint inflexibility at ankle and hip joints might be such a major cause, leading to small variability in the center of pressure (CoP) during quiet stance. However, this conjecture is still controversial. Thus, quantitative characterization of CoP patterns during quiet stance in PD patients remains a matter of research...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226338/opioids-inhibit-angiogenesis-in-a-chorioallantoic-membrane-model
#13
Haktan Karaman, Adnan Tufek, Evren Karaman, Orhan Tokgoz
BACKGROUND: Angiogenesis is an important characteristic of cancer. Switching from the avascular phase to the vascular phase is a necessary process for tumor growth. Therefore, research in cancer treatment has focused on angiogenesis as a drug target. Despite the widespread use of opioids to treat pain in patients with cancer, little is known about the effect of these drugs on vascular endothelium and angiogenesis. OBJECTIVES: We aimed to investigate the efficacies of morphine, codeine, and tramadol in 3 different concentrations on angiogenesis in hens' eggs...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28226332/responsible-safe-and-effective-prescription-of-opioids-for-chronic-non-cancer-pain-american-society-of-interventional-pain-physicians-asipp-guidelines
#14
Laxmaiah Manchikanti, Adam M Kaye, Nebojsa Nick Knezevic, Heath McAnally, Konstantin Slavin, Andrea M Trescot, Susan Blank, Vidyasagar Pampati, Salahadin Abdi, Jay S Grider, Alan D Kaye, Kavita N Manchikanti, Harold Cordner, Christopher G Gharibo, Michael E Harned, Sheri L Albers, Sairam Atluri, Steve M Aydin, Sanjay Bakshi, Robert L Barkin, Ramsin M Benyamin, Mark V Boswell, Ricardo M Buenaventura, Aaron K Calodney, David L Cedeno, Sukdeb Datta, Timothy R Deer, Bert Fellows, Vincent Galan, Vahid Grami, Hans Hansen, Standiford Helm Ii, Rafael Justiz, Dhanalakshmi Koyyalagunta, Yogesh Malla, Annu Navani, Kent H Nouri, Ramarao Pasupuleti, Nalini Sehgal, Sanford M Silverman, Thomas T Simopoulos, Vijay Singh, Daneshvari R Solanki, Peter S Staats, Ricardo Vallejo, Bradley W Wargo, Arthur Watanabe, Joshua A Hirsch
BACKGROUND: Opioid use, abuse, and adverse consequences, including death, have escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse, numerous regulations and guidelines for responsible opioid prescribing have been developed by various organizations. However, the US opioid epidemic is continuing and drug dose deaths tripled during 1999 to 2015. Recent data show a continuing increase in deaths due to natural and semisynthetic opioids, a decline in methadone deaths, and an explosive increase in the rates of deaths involving other opioids, specifically heroin and illicit synthetic fentanyl...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28226183/development-of-an-acceptable-and-feasible-self-management-group-for-children-young-people-and-families-living-with-type-1-diabetes
#15
R A Cai, R I G Holt, L Casdagli, R M Viner, R Thompson, K Barnard, D Christie
AIMS: This study developed an acceptable and feasible self-management intervention that addresses the self-identified needs of children and young people with Type 1 diabetes and their parents. METHODS: Phase 1 reviewed previous interventions and interviewed the clinical team, young people and families. Phase 2 ran three age-matched focus groups with 11 families of children aged 8-16 years. Feedback was used to modify the workshop. Phase 3 evaluated feasibility of delivery, as well as the effects on metabolic control, quality of life and fear of hypoglycaemia, measured at baseline and 1-3 months post intervention...
February 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28225955/the-role-of-intradermal-proliferation-of-t-cells-in-the-pathogenesis-of-psoriasis
#16
Vladislav R Khairutdinov, Anastasiya F Mikhailichenko, Irena E Belousova, Ekatherina Sh Kuligina, Alexey V Samtsov, Evgeny N Imyanitov
BACKGROUND: Psoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph nodes and their subsequent migration into the skin through the blood system. Here we provide evidence that psoriatic plaque itself may serve as a source of inflammatory T-cells. OBJECTIVE: We examined the intradermal proliferation of T-cells and the number of effector/memory (CD45RO+) T-cells in the skin of psoriatic patients at different periods of the disease...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28225761/amplified-stimulated-emission-in-upconversion-nanoparticles-for-super-resolution-nanoscopy
#17
Yujia Liu, Yiqing Lu, Xusan Yang, Xianlin Zheng, Shihui Wen, Fan Wang, Xavier Vidal, Jiangbo Zhao, Deming Liu, Zhiguang Zhou, Chenshuo Ma, Jiajia Zhou, James A Piper, Peng Xi, Dayong Jin
Lanthanide-doped glasses and crystals are attractive for laser applications because the metastable energy levels of the trivalent lanthanide ions facilitate the establishment of population inversion and amplified stimulated emission at relatively low pump power. At the nanometre scale, lanthanide-doped upconversion nanoparticles (UCNPs) can now be made with precisely controlled phase, dimension and doping level. When excited in the near-infrared, these UCNPs emit stable, bright visible luminescence at a variety of selectable wavelengths, with single-nanoparticle sensitivity, which makes them suitable for advanced luminescence microscopy applications...
February 22, 2017: Nature
https://www.readbyqxmd.com/read/28225674/inhibiting-plasma-kallikrein-for-hereditary-angioedema-prophylaxis
#18
Aleena Banerji, Paula Busse, Mustafa Shennak, William Lumry, Mark Davis-Lorton, Henry J Wedner, Joshua Jacobs, James Baker, Jonathan A Bernstein, Richard Lockey, H Henry Li, Timothy Craig, Marco Cicardi, Marc Riedl, Ahmad Al-Ghazawi, Carolyn Soo, Ryan Iarrobino, Daniel J Sexton, Christopher TenHoor, Jon A Kenniston, Ryan Faucette, J Gordon Still, Harvey Kushner, Robert Mensah, Chris Stevens, Joseph C Biedenkapp, Yung Chyung, Burt Adelman
Background Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high-molecular-weight kininogen. Lanadelumab (DX-2930) is a new kallikrein inhibitor with the potential for prophylactic treatment of hereditary angioedema with C1 inhibitor deficiency. Methods We conducted a phase 1b, multicenter, double-blind, placebo-controlled, multiple-ascending-dose trial...
23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28225669/mr-enterography-assessment-of-bowel-inflammation-severity-in-crohn-disease-using-the-mr-index-of-activity-score-modifying-roles-of-dwi-and-effects-of-contrast-phases
#19
Jin Sil Kim, Hye Young Jang, Seong Ho Park, Kyung-Jo Kim, Kyunghwa Han, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park, Jong Seok Lee, Hyun Jin Kim
OBJECTIVE: The purpose of this article is to appraise the use of the MR index of activity (MaRIA) score in evaluating Crohn disease (CD) on present-day MR enterography images, with an emphasis on determining the modifying roles of DWI and the effects of different contrast enhancement phases. SUBJECTS AND METHODS: Fifty patients prospectively underwent MR enterography, including DWI and enteric and portal phase scans, and ileocolonoscopy with segmental CD endoscopic index of severity (CDEIS) scoring within a week...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28225610/intramolecular-energy-and-electron-transfer-within-a-diazaperopyrenium-based-cyclophane
#20
Xirui Gong, Ryan M Young, Karel J Hartlieb, Claire Miller, Yilei Wu, Hai Xiao, Peng Li, Nema Hafezi, Jiawang Zhou, Lin Ma, Tao Cheng, William A Goddard, Omar K Farha, Joseph T Hupp, Michael R Wasielewski, J Fraser Stoddart
Molecules capable of performing highly efficient energy transfer and ultrafast photo-induced electron transfer in well-defined multichromophoric structures are indispensable to the development of artificial photosynthetic systems. Herein, we report on the synthesis, characterization and photophysical properties of a rationally designed multichromophoric tetracationic cyclophane, DAPPBox(4+), containing a diazaperopyrenium (DAPP(2+)) unit and an extended viologen (ExBIPY(2+)) unit, which are linked together by two p-xylylene bridges...
February 22, 2017: Journal of the American Chemical Society
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