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Phase 1

Narayan Balaji, Suresh P Sulochana, Neeraj Kumar Saini, Siva Kumar A, Ramesh Mullangi
A simple, selective and reliable LC-MS/MS method was developed and validated for the simultaneous quantitation of darolutamide diastereomers (diastereomer-1 and diastereomer-2) and its active metabolite i. e. ORM-15341 in mice plasma using warfarin as an internal standard (IS) as per the regulatory guidelines. Plasma samples were extracted by liquid-liquid extraction and the chromatographic separation was achieved on a Chiralpak IA column with an isocratic mobile phase 5 mM ammonium acetate:absolute alcohol (20:80, v/v) at a flow rate of 1...
March 20, 2018: Drug Research
Piotr Rożek, Magdalena Król, Włodzimierz Mozgawa
In the present work fly-ash based geopolymers with different contents of alkali-activator and water were prepared. Alkali-activation was conducted with sodium hydroxide (NaOH) at the SiO2 /Na2 O molar ratio of 3, 4, and 5. Water content was at the ratio of 30, 40, and 50wt% in respect to the weight of the fly ash. Structural and microstructural characterization (FT-IR spectroscopy,29 Si and27 Al MAS NMR, X-ray diffraction, SEM) of the specimens as well as compressive strength and apparent density measurements were carried out...
March 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Bradley Fawver, Jaimie A Roper, Carolina Sarmento, Chris J Hass
We investigated the impact of initial body position on the displacement and velocity of center of pressure adjustments made during gait initiation. Twenty-nine healthy adults (21 ± 1y) initiated forward gait following six seconds of sustained forward posture based on percentage of their forward maximum voluntary lean (0, 5, 10, 20, 50%). Final center of pressure positions for each trial were back-calculated, as a percentage of maximum voluntary lean, using average anteroposterior constant error to the target during the last second of feedback...
March 17, 2018: Human Movement Science
Wei Wu, Jin Wang, Peter Ercius, Nicomario Courtney Wright, Danielle Marie Leppert-Simenauer, Robert A Burke, Madan Dubey, Avinash M Dongare, Michael Thompson Pettes
Transition metal dichalcogenides (TMDs) are particularly sensitive to mechanical strain as they are capable of experiencing high atomic displacements without nucleating defects to release excess energy. Promising for photonic applications, it has been shown that as certain phases of layered TMDs MX2 (M=Mo, W; X=S, Se, Te) are scaled to a thickness of one monolayer, the photoluminescence response is dramatically enhanced due to the emergence of a direct electronic band gap, compared with their multi-layer or bulk counterparts which typically exhibit indirect band gaps...
March 20, 2018: Nano Letters
Alfonso Méndez-Bravo, Elvis Marian Cortazar-Murillo, Edgar Guevara-Avendaño, Oscar Ceballos-Luna, Benjamín Rodríguez-Haas, Ana L Kiel-Martínez, Orlando Hernández-Cristóbal, José A Guerrero-Analco, Frédérique Reverchon
Rhizobacteria associated with crops constitute an important source of potentially beneficial microorganisms with plant growth promoting activity or antagonistic effects against phytopathogens. In this study, we evaluated the plant growth promoting activity of 11 bacterial isolates that were obtained from the rhizosphere of healthy avocado trees and from that of avocado trees having survived root rot infestations. Seven bacterial isolates, belonging to the genera Bacillus, Pseudomonas and Arthrobacter, promoted in vitro growth of Arabidopsis thaliana...
2018: PloS One
Cornelia Wiegand, Andrea Völpel, Andrea Ewald, Markko Remesch, Jan Kuever, Janine Bauer, Stefanie Griesheim, Carolin Hauser, Julian Thielmann, Silke Tonndorf-Martini, Bernd W Sigusch, Jürgen Weisser, Ralf Wyrwa, Peter Elsner, Uta-Christina Hipler, Martin Roth, Carolin Dewald, Claudia Lüdecke-Beyer, Jörg Bossert
Bactericidal materials gained interest in the health care sector as they are capable of preventing material surfaces from microbial colonization and subsequent spread of infections. However, commercialization of antimicrobial materials requires proof of their efficacy, which is usually done using in vitro methods. The ISO 22196 standard (Japanese test method JIS Z 2801) is a method for measuring the antibacterial activity of daily goods. As it was found reliable for testing the biocidal activity of antimicrobially active materials and surface coatings most of the laboratories participating in this study used this protocol...
2018: PloS One
Quanwei Zhang, Qi Wang, Jishang Gong, Jiaxing Du, Yong Zhang, Xingxu Zhao
Insulin-like growth factor 2 (IGF2) recapitulates many of the activities of insulin and promotes differentiation of myoblasts and osteoblasts, which likely contribute to genetic variations of growth potential. However, little is known about the functions and signaling properties of IGF2 variants in yaks. The over-expression vector and knockdown sequence of yak IGF2 were transfected into yak fibroblasts, and the effects were detected by a series of assays. IGF2 expression in yak muscle tissues was significantly lower than that of other tissues...
March 20, 2018: Genes
Lídia Resende Oliveira, Susane B Moscardini, Eduardo F Molina, Eduardo José Nassar, Marc Verelst, Lucas Alonso Rocha
In this work, we have investigated how the concentration of Gd<sup>3+</sup> ions affects the structural and luminescent properties of niobium oxide-based matrices doped with Eu<sup>3+</sup> ions obtained by the adapted non-hydrolytic sol-gel route. The X-ray diffractograms revealed that increasing concentration of Gd<sup>3+</sup> ions favored the onset of the Gd<sub>2</sub>O<sub>3</sub> structure decreasing the GdNbO<sub>4</sub> phase...
March 20, 2018: Nanotechnology
Sven Haller, Meike W Vernooij, Joost P A Kuijer, Elna-Marie Larsson, Hans Rolf Jäger, Frederik Barkhof
Cerebral microbleeds (CMBs), also referred to as microhemorrhages, appear on magnetic resonance (MR) images as hypointense foci notably at T2*-weighted or susceptibility-weighted (SW) imaging. CMBs are detected with increasing frequency because of the more widespread use of high magnetic field strength and of newer dedicated MR imaging techniques such as three-dimensional gradient-echo T2*-weighted and SW imaging. The imaging appearance of CMBs is mainly because of changes in local magnetic susceptibility and reflects the pathologic iron accumulation, most often in perivascular macrophages, because of vasculopathy...
April 2018: Radiology
Reshma Jagsi, Kent A Griffith, Jennifer R Bellon, Wendy A Woodward, Janet K Horton, Alice Ho, Felix Y Feng, Corey Speers, Beth Overmoyer, Michael Sabel, Anne F Schott, Lori Pierce
Purpose Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP-ribose) polymerase inhibitors are used as radiosensitizers; clinical investigation is necessary to establish appropriate dosing and confirm safety. Patients and Methods We conducted a multi-institutional phase I study of veliparib and concurrent radiotherapy (RT) to the chest wall and regional lymph nodes in 30 patients with inflammatory or locally recurrent breast cancer after complete surgical resection...
March 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Shih-Liang Hsi, Peter Surman, Raida Al-Kassas
A highly sensitive and rapid stability indicating Ultra Performance Liquid Chromatographic (UPLC) method was developed for the quantification and identification of isotretinoin in bulk. Chromatographic separation was developed using a gradient elution in a reversed-phase system at flow rate of 0.5 ml/min with 12 minutes run time. The mobile phase was a gradient mixture of mobile phase A (contained a 30:70:0.5 mixture solution of methanol/Purified water/Glacial Acetic Acid) and mobile phase B (contained a 70:25:4...
March 20, 2018: Pharmaceutical Development and Technology
Stephen Ashford, Heather Williams, Ajoy Nair, Samantha Orridge, Lynne Turner-Stokes
BACKGROUND: Goal-classification of person-centred goals, using Goal Attainment Scaling for leg spasticity treatment. METHODS: The study was conducted in two phases: phase I, a retrospective review to evaluate categories of goal set in routine clinical practice. Findings were used to design a goal classification system. Phase II, a multi-centre study to confirm the goal categories. Goals set (n = 270) were analysed from data collected at three centres in the UK (one centre for phase I)...
March 20, 2018: Disability and Rehabilitation
Audrey R C Elias, Kari J Harris, Paul C LaStayo, Ryan L Mizner
BACKGROUND: Limited knee flexion and increased muscle co-contraction during jump landing are believed to diminish outcomes after anterior cruciate ligament (ACL) reconstruction. The efficacy of jump training to improve patients' mechanical and neuromuscular deficits is understudied. HYPOTHESIS: Jump training will improve functional, mechanical, and neuromuscular outcomes and higher repetition training augmented by body weight support will result in better retention of gains...
March 1, 2018: American Journal of Sports Medicine
Rajesh Sharma, Lalit Kumar Saini, Bhagwati Prasad Bahuguna
We study the phase diagram of symmetric electron-hole bilayer at zero temperature and zero magnetic field within quantum Monte Carlo approach. Particularly, we conduct variational Monte Carlo simulation for various phases viz. paramagnetic fluid phase, ferromagnetic fluid phase, anti-ferromagnetic Wigner crystal phase, ferromagnetic Wigner crystal phase and excitonic phase to
 estimate the ground-state energy at different values of inlayer density and inter-layer spacing. The Slater-Jastrow style trial wave function, with suitable single particle orbitals appropriate for different phases, are used to construct the phase diagram in (r<sub>s</sub> , d) plane by finding relative stability of trial wave functions...
March 20, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Simon Drescher, Christian Otto, Sindy Müller, Vasil M Garamus, Christopher J Garvey, Susanne Grünert, Anke Lischka, Annette Meister, Alfred Blume, Bodo Dobner
In the present work, we describe the synthesis and the temperature-dependent aggregation behavior of a new class of asymmetrical glycerol diether bolalipid. These bolalipids are composed of a membrane-spanning alkyl chain with 32 carbon atoms (C32) in the sn-3 position, a methyl-branched C16 alkyl chain in the sn-2 position, and a zwitterionic phosphocholine headgroup in the sn-1 position of a glycerol moiety. The long C32 alkyl chain is terminated either by a second phos-phocholine (PC-Gly(2C16Me)C32-PC) or by a phosphodimethylethanolamine headgroup (PC-Gly(2C16Me)C32-Me2PE)...
March 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Alexandre Khaldi, Daniel Falk, Katarina Bengtsson, Ali Maziz, Daniel Filippini, Nathaniel D Robinson, Edwin W H Jager
There is a need for soft actuators in various biomedical applications in order to manipulate delicate objects such as cells and tissues. Soft actuators are able to adapt to any shape and limit the stress applied to delicate objects. Conjugated polymer actuators, especially in the so-called trilayer configuration, are interesting candidates for driving such micromanipulators. However, challenges involved in patterning the electrodes in a trilayer with individual contact have prevented further development of soft micromanipulators based on conjugated polymer actuators...
March 20, 2018: ACS Applied Materials & Interfaces
A Gupta, H J H Clercx, F Toschi
Particle-laden turbulent flows occur in a variety of industrial applications as well as in naturally occurring flows. While the numerical simulation of such flows has seen significant advances in recent years, it still remains a challenging problem. Many studies investigated the rheology of dense suspensions in laminar flows as well as the dynamics of point-particles in turbulence. Here we employ a fully-resolved numerical simulation based on a lattice Boltzmann scheme, to investigate turbulent flow with large neutrally buoyant particles in a pipe flow at low Reynolds number and in dilute regimes...
March 21, 2018: European Physical Journal. E, Soft Matter
Margherita Maiuri, Johanna Brazard
During the last two decades, 2D optical techniques have been extended to the visible range, targeting electronic transitions. Since the report of the very first 2D electronic measurement (Hybl et al. in J Chem Phys 115:6606-6622, [2001]), two-dimensional electronic spectroscopy (2DES) has allowed fundamentally new insights into the structure and dynamics of condensed-phase systems (Ginsberg et al. in Acc Chem Res 42:1352-1363, 2009; Jonas in Annu Rev Phys Chem 54:425-463, 2003), producing experiments that measure correlations among electronic states of an absorbing species within complex systems...
March 20, 2018: Topics in Current Chemistry (Journal)
Kengran Yang, V Ongun Özçelik, Nishant Garg, Kai Gong, Claire E White
Conventional drying of colloidal materials and gels (including cement) can lead to detrimental effects due to the buildup of internal stresses as water evaporates from the nano/microscopic pores. However, for these gel materials the underlying nanoscopic alterations that are, in part, responsible for macroscopically-measured strain values (especially at low relative humidity) remain a topic of open debate in the literature. In this study, sodium-based calcium-alumino-silicate-hydrate (C-(N)-A-S-H) gel, the major binding phase of silicate-activated blast furnace slag (one type of low-CO2 cement), is investigated from a drying perspective, since it is known to suffer extensively from drying-induced microcracking...
March 20, 2018: Physical Chemistry Chemical Physics: PCCP
Yukako Eguchi, Yoshihiro Fukumori, Azuma Taoka
Magnetotactic bacteria synthesize uniform-sized and regularly shaped magnetic nanoparticles in their organelles termed magnetosomes. Homeostasis of the magnetosome lumen must be maintained for its role accomplishment. Here, we developed a method to estimate the pH of a single living cell of the magnetotactic bacterium Magnetospirillum magneticum AMB-1 using a pH-sensitive fluorescent protein E2 GFP. Using the pH measurement, we estimated that the cytoplasmic pH was approximately 7.6 and periplasmic pH was approximately 7...
March 20, 2018: Bioscience, Biotechnology, and Biochemistry
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