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Multiple schlerosis

Anne-Mette Momsen, Jens Ole Rasmussen, Claus Vinther Nielsen, Maura Daly Iversen, Hans Lund
OBJECTIVES: To systematically investigate current scientific evidence about the effectiveness of multidisciplinary team rehabilitation for different health problems. DATA SOURCES: A comprehensive literature search was conducted in Cochrane, Medline, DARE, Embase, and Cinahl databases, and research from existing systematic reviews was critically appraised and summarized. STUDY SELECTION: Using the search terms "rehabilitation", "multidisciplinary teams" or "team care", references were identified for existing studies published after 2000 that examined multidisciplinary rehabilitation team care for adults, without restrictions in terms of study population or outcomes...
November 2012: Journal of Rehabilitation Medicine
William J. Karpus, Kevin J. Kennedy, Brian T. Fife, Lisa M. Hoffman
Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating disease of the central nervous system (CNS), which serves as a model for multiple schlerosis (MS). A hallmark in the pathogenesis of this disease is the emigration of T cells and monocytes from the blood to the CNS. Chemokines are small-molecular-weight chemotactic peptides, which are ligands for seven transmembrane-spanning, G protein-coupled receptors and which deliver signals leading to a variety of T cell functions including costimulation, cytokine expression, differentiation, and integrin activation...
September 1999: ILAR Journal
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