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old age psychiatry

G Kaur, M Pawlik, S E Gandy, M E Ehrlich, J F Smiley, E Levy
Recent data suggest that intraneuronal accumulation of metabolites of the amyloid-β-precursor protein (APP) is neurotoxic. We observed that transgenic mice overexpressing in neurons a human APP gene harboring the APP(E693Q) (Dutch) mutation have intraneuronal lysosomal accumulation of APP carboxylterminal fragments (APP-CTFs) and oligomeric amyloid β (oAβ) but no histological evidence of amyloid deposition. Morphometric quantification using the lysosomal marker protein 2 (LAMP-2) immunolabeling showed higher neuronal lysosomal counts in brain of 12-months-old APP(E693Q) as compared with age-matched non-transgenic littermates, and western blots showed increased lysosomal proteins including LAMP-2, cathepsin D and LC3...
October 25, 2016: Molecular Psychiatry
Mark Haddad, Ahmed Waqas, Wahhaj Qayyum, Maryam Shams, Saad Malik
BACKGROUND: Mental disorders such as depression are common and rank as major contributors to the global burden of disease. Condition recognition and subsequent management of depression is variable and influenced by the attitudes and beliefs of clinicians as well as those of patients. Most studies examining health professionals' attitudes have been conducted in Western nations; this study explores beliefs and attitudes about depression among doctors working in Lahore, Pakistan. METHODS: A cross-sectional survey conducted in 2015 used a questionnaire concerning demographics, education in psychiatry, beliefs about depression causes, and attitudes about depression using the Revised Depression Attitude Questionnaire (R-DAQ)...
October 18, 2016: BMC Psychiatry
Seval Birdal, Burak Doğangün
AIM: Enuresis is defined as involuntary or intentional repeated voiding of urine into clothes or bed at least twice a week for a period of three consecutive months in children older than five years old. It is one of the most frequent chronic childhood disorders. The aim of this study was to investigate the frequency of behavioural problems in children with enuresis. MATERIAL AND METHODS: The research compared 30 children aged between 7 and 11 years who had consulted to Bakırköy Prof...
September 2016: Türk Pediatri Arşivi
Luqman Helmi, David Meagher, Edmond O'Mahony, Donagh O'Neill, Owen Mulligan, Sutha Murthy, Geraldine McCarthy, Dimitrios Adamis
AIM: To explore the agreement between the mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales. METHODS: Prospective study of consecutive patients attending outpatient services. Both tests were administered by the same researcher on the same day in random order. RESULTS: The total sample (n = 135) was randomly divided into two groups...
September 22, 2016: World Journal of Psychiatry
Frans Clignet, Berno van Meijel, Annemieke van Straten, Pim Cuijpers
PURPOSE: This article describes the evaluation of the implementation of a nursing intervention, that is, the Systematic Activation Method (SAM), among inpatients with late life depression (LLD). METHODS: A qualitative study in four clinical units for old age psychiatry. RESULTS: We identified facilitators and barriers relating to patient and nurse characteristics, as well as to contextual factors, from the perspective of mental health nurses...
September 14, 2016: Perspectives in Psychiatric Care
B Lavigne, E Audebert-Mérilhou, G Buisson, F Kochman, J P Clément, B Olliac
INTRODUCTION: Depression disorder may become the first cause of morbidity by 2030, according to the World Health Organization. It is actually one of the main causes of disease and handicap in children aged from 10 to 19. The major risk is suicide, whose prevalence is estimated, in France, around 6.7 for 100,000, which is probably underestimated. At present, the discussions about prescription of antidepressants in an adolescent's depression remain intense which is why psychotherapy becomes the first choice of treatment...
September 9, 2016: L'Encéphale
Romain Arnal, Gülen Ayhan, Éric Pinganaud, Célia Basurko, Louis Jehel
Despite the recent interest in psychiatric illness in prison, the psychopathology of the Remire-Montjoly prison population remains largely unknown. Subject to significant population movements, French Guiana and its prison houses a very mixed population in which recent history has left a strong mark (earthquake in Haïti, civil war in Suriname, violence related to gold mining population and drug trafficking). These negative life events appear as potential vectors of psychological trauma. Additionally, strong links have been established in the literature between post-traumatic stress disorder (PTSD) and many other psychiatric disorders, including suicidal behavior and addictions...
2016: Santé Mentale Au Québec
Marc E Lavoie, Julie Champagne, Emma Glaser, Adrianna Mendrek
Context Abnormal emotion processing is frequent in schizophrenia and affects social and functional outcome. Past event-related potential (ERP) research investigating processing of affective stimuli in schizophrenia was done mainly with facial expressions and revealed impaired facial emotion recognition in patients relative to control subjects. Experimentations involving fMRI with this group of patients, showed alteration of limbic and frontal regions in response to emotional unpleasant images, compared to neutral stimuli during a memory task...
2016: Santé Mentale Au Québec
Sue Tucker, Claire Hargreaves, Mark Wilberforce, Christian Brand, David Challis
OBJECTIVES: The study sought to identify the variables associated with increased length of stay on old age psychiatry inpatient wards. It also explored the factors related to delayed discharge and the likelihood of patients admitted from home returning there. METHODS: Data were collected on the sociodemographic, clinical and service receipt characteristics of a 6-month series of admissions to seven wards in England in 2010/2011. The cohort was followed for a 9- to 11-month period...
August 12, 2016: International Journal of Geriatric Psychiatry
Maria Moura, Amilcar Silva-Dos-Santos, Joana Afonso, Miguel Talina
BACKGROUND: Anti-NMDA receptor encephalitis is an autoimmune disease that was identified in 2007, and manifests in a stepwise manner with psychiatric, neurological and autonomic symptoms. The disease is caused by autoantibodies against NMDA receptors. It can have a paraneoplastic origin, mainly secondary to ovarian teratomas, but it can also be unrelated to the tumor. This disease can affect both sexes and all ages. CASE PRESENTATION: Here, we present a case of a 15 year-old female adolescent with first-episode psychosis with anti-NMDA receptor encephalitis not related to tumor, which manifested with delusion, hallucinations, panic attacks, agitation, and neurological symptoms, and later with autonomic instability...
July 29, 2016: BMC Research Notes
Laura A Kaehler, Mary Jacobs, Deborah J Jones
There is a shift in evidence-based practice toward an understanding of the treatment elements that characterize empirically supported interventions in general and the core components of specific approaches in particular. The evidence base for behavioral parent training (BPT) and the standard of care for early-onset disruptive behavior disorders (oppositional defiant disorder and conduct disorder), which frequently co-occur with attention deficit hyperactivity disorder, are well established, yet an ahistorical, program-specific lens tells little regarding how leaders, University of Oregon Medical School, shaped the common practice elements of contemporary evidence-based BPT...
September 2016: Clinical Child and Family Psychology Review
Laura Korhonen, Pekka Tani
Treatment paths in psychiatry may extend from infancy to old age, particularly in neuropsychiatric patients. In the diagnostics and treatment it is important to consider the variations in the symptoms and focuses of rehabilitation during the different periods of the life cycle. Good care and its provision require a perspective extending through the lifespan and assurance of continuity. In our case report we describe a treatment path of 20 years' duration of our neuropsychiatric patient
2016: Duodecim; Lääketieteellinen Aikakauskirja
J J Sandra Kooij, Marieke Michielsen, Henk Kruithof, Denise Bijlenga
INTRODUCTION: ADHD is an often heritable, neurodevelopmental disorder with a prevalence of 4-5% in children and adults and about 3% in older adults. The disorder in older adults (> 55 years) is accompanied by similar comorbidities such as anxiety and depression, and social impairment as in younger age groups. AREAS COVERED: An overview of the literature on diagnostic assessment, differential diagnosis, and treatment of older adults with ADHD is described. Case studies show that stimulant treatment is beneficial for ADHD in old age, but randomized controlled trials are lacking...
July 4, 2016: Expert Review of Neurotherapeutics
Christian Jagsch, Gabriele Dietmaier, Maximilian Jagsch, Martin Kurz
BACKGROUND: The objective of this study was to survey the consistency of the clinical diagnostics and the psychopharmacological treatment of schizophrenia and delusional disorders suffered by older persons. A further aspect was to record significant clinical differences and also similarities between the patient groups in care, matching with the criteria of ICD 10 for schizophrenia (F20), persistent delusional disorders (F22) and schizoaffective disorder (F25). METHODS: Retrospective analysis with reference to the manually and electronically recorded patient medical records of an acute case care ward for geriatric psychiatry and psychotherapy...
June 2016: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
Karsten Ebbing
Behavioral and psychological symptoms of dementia (BPSD) are frequent and represent a challenge for an optimal care of patients. They must be investigated systematically and if necessary analyzed with specialized teams in the domain of old age Psychiatry so that these disorders are optimally addressed and complications are prevented. A precise analysis of potential causes of BPSD in concertation with both family members and caring team allows clinicians to avoid the use of drugs that may appear to solve the immediate issue but happen to have serious side effects or even toxicity over time...
April 20, 2016: Revue Médicale Suisse
Francy de Brito Ferreira Fernandes, Alexandre Duarte Gigante, Mariangeles Berutti, José Antônio Amaral, Karla Mathias de Almeida, Cristiana Castanho de Almeida Rocca, Beny Lafer, Fabiano Gonçalves Nery
BACKGROUND: Facial emotion recognition (FER) is an important task associated with social cognition because facial expression is a significant source of non-verbal information that guides interpersonal relationships. Increasing evidence suggests that bipolar disorder (BD) patients present deficits in FER and these deficits may be present in individuals at high genetic risk for BD. The aim of this study was to evaluate the occurrence of FER deficits in euthymic BD patients, their first-degree relatives, and healthy controls (HC) and to consider if these deficits might be regarded as an endophenotype candidate for BD...
July 2016: Comprehensive Psychiatry
S Rangaraju, D F Levey, K Nho, N Jain, K D Andrews, H Le-Niculescu, D R Salomon, A J Saykin, M Petrascheck, A B Niculescu
Antidepressants have been shown to improve longevity in C. elegans. It is plausible that orthologs of genes involved in mood regulation and stress response are involved in such an effect. We sought to understand the underlying biology. First, we analyzed the transcriptome from worms treated with the antidepressant mianserin, previously identified in a large-scale unbiased drug screen as promoting increased lifespan in worms. We identified the most robust treatment-related changes in gene expression, and identified the corresponding human orthologs...
August 2016: Molecular Psychiatry
Colleen Doyle, David Jackson, Samantha Loi, Sue Malta, Kirsten Moore
BACKGROUND: While videoconferencing, telementoring, and peer support have been shown to enhance services in some instances, there has been no research investigating the use of these technologies in supporting professionals managing clients with dementia. The objective of this research was to evaluate expansion of an old age psychiatry consultation service and pilot test a model to improve medical supervision and clinical governance for staff within regional and remote areas using remote information technology...
September 2016: International Psychogeriatrics
E Berm, R Kok, E Hak, B Wilffert
Objectives: To determine relations between drug concentrations and the cytochrome P450-CYP2D6 genotype or phenotype among elderly patients treated with nortriptyline or venlafaxine. Methods: A post-hoc analysis of a clinical trial was performed. Patients were grouped into phenotypes according to the metabolite/mother compound ratio. Genotypes were assessed by the CYP2D6 *3 and *4 alleles. Results: Data was available from 81 patients (41 nortriptyline, 40 venlafaxine) with a mean age of 72 years. No phenoconversion from poor metabolizers (PM) to extensive metabolizers (EM), or vice versa, was found...
April 21, 2016: Pharmacopsychiatry
Josephine Beatson, Jillian Helen Broadbear, Hemalatha Sivakumaran, Kuruvilla George, Eli Kotler, Francine Moss, Sathya Rao
OBJECTIVE: Clinical experience suggests a growing prevalence of borderline personality disorder in aged residential care and psychiatric facilities with attendant difficulties in their management. This paper reviews the literature concerning the prevalence, phenomenology and diagnosis of borderline personality disorder in old age. The aim is to elucidate the phenomenological differences in old age and thus improve identification of the disorder. METHODS: A systematic search was conducted using MEDLINE, PubMed, EMBASE and PsycINFO databases, employing the search terms including 'personality disorder', 'borderline personality disorder', 'aged care', 'gerontology', 'geriatric psychiatry' and 'life span'...
April 7, 2016: Australian and New Zealand Journal of Psychiatry
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