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JOURNAL ARTICLE
Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño, Jefferson Antonio Buendia
OBJECTIVES: Although the efficacy of the addition of ipratropium bromide (IB) to short-acting β2-agonists (SABAs) for treating children with moderate to severe asthma exacerbations has been demonstrated, evidence of its cost-effectiveness is scarce. The aim of the present study was to evaluate the cost-effectiveness of treatment with a combination of SABAs and IB compared with SABAs alone for the treatment of children with moderate to severe asthma exacerbations. METHODS: To achieve the objectives of the study, a decision-analysis model was adapted...
December 2021: Pediatric Pulmonology
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JOURNAL ARTICLE
Mevlüt Yılmaz, Osman Ahmet Polat, Duygu Zorlu Karayiğit, Taha Ayyıldız
BACKGROUND: This study aimed to investigate whether the choroidal vascularity index (CVI), choroidal thickness (ChT), and retinal nerve fiber thickness (RNFL) of patients with allergic asthma change compared to the healthy control group. METHODS: This cross-sectional, observational study comprised 59 eyes of 59 patients with allergic asthma (Group 1) and 50 eyes of 50 age and sex-matched healthy volunteers as a control group (Group 2). CVI was measured by binarization of images obtained from choroidal enhanced depth imaging (EDI) mode optic coherence tomography...
August 24, 2021: Photodiagnosis and Photodynamic Therapy
#23
JOURNAL ARTICLE
Narmeen Mallah, Julia May Turner, Francisco-Javier González-Barcala, Bahi Takkouche
BACKGROUND: Gastroesophageal reflux disease (GORD) is highly prevalent and often coexists with asthma exacerbation. Divergent findings about the association between the two diseases were reported. We conducted a systematic review and meta-analysis to determine whether there exists an association between GORD and asthma. METHODS: We searched MEDLINE, EMBASE, and other databases and then performed a manual search, to identify eligible studies. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using fixed- and random-effect models...
January 2022: Pediatric Allergy and Immunology
#24
EDITORIAL
Maria Popa, Gheorghe Peltecu, Nicolae Gica, Anca Marina Ciobanu, Radu Botezatu, Corina Gica, Alexandru Steriade, Anca Maria Panaitescu
Background: Asthma is the most common respiratory disorder affecting women during pregnancy. Although it is a reversible disease, it may adversely affect maternal quality of life and perinatal outcomes, especially in severe and inappropriately managed cases. Conversely, pregnancy influences the course of asthma through the physiological respiratory, hormonal, and immune system changes. Exacerbations are a key feature of asthma, representing a significant problem if severe, requiring aggressive medical intervention, hospital and even ICU admission...
March 2021: Mædica
#25
MULTICENTER STUDY
Lucie Bartova, Gernot Fugger, Markus Dold, Marleen Margret Mignon Swoboda, Joseph Zohar, Julien Mendlewicz, Daniel Souery, Stuart Montgomery, Chiara Fabbri, Alessandro Serretti, Siegfried Kasper
Despite plenty of effective antidepressant (AD) treatments, the outcome of major depressive disorder (MDD) is often unsatisfactory, probably due to improvable exploitation of available therapies. This European, cross-sectional, naturalistic multicenter study investigated the frequency of additional psychotherapy in terms of a manual-driven psychotherapy (MDP) in 1410 adult in- and outpatients with MDD, who were primarily treated with AD psychopharmacotherapy. Socio-demographic and clinical patterns were compared between patients receiving both treatments and those lacking concomitant MDP...
September 2021: Journal of Psychiatric Research
#26
REVIEW
Wenqian Wang, Qiang Yao, Fangzhou Teng, Jie Cui, Jingcheng Dong, Ying Wei
Although considerable advance has been made in diagnosing and treating, asthma is still a serious public health challenge. Traditional Chinese medicine (TCM) is an effective therapy of complementary and alternative medicine. More and more scientific evidences support the use of TCM for asthma treatment, and active ingredients from Chinese medicine plants are becoming a hot issue. PURPOSE OF REVIEW: To summarize the frontier knowledge on the function and underlying mechanisms of the active ingredients in asthma treatments and provide a fully integrated, reliable reference for exploring innovative treatments for asthma...
May 2021: Biomedicine & Pharmacotherapy
#27
JOURNAL ARTICLE
Pierre Côté, Jan Hartvigsen, Iben Axén, Charlotte Leboeuf-Yde, Melissa Corso, Heather Shearer, Jessica Wong, Andrée-Anne Marchand, J David Cassidy, Simon French, Gregory N Kawchuk, Silvano Mior, Erik Poulsen, John Srbely, Carlo Ammendolia, Marc-André Blanchette, Jason W Busse, André Bussières, Carolina Cancelliere, Henrik Wulff Christensen, Diana De Carvalho, Katie De Luca, Alister Du Rose, Andreas Eklund, Roger Engel, Guillaume Goncalves, Jeffrey Hebert, Cesar A Hincapié, Maria Hondras, Amanda Kimpton, Henrik Hein Lauridsen, Stanley Innes, Anne-Laure Meyer, David Newell, Søren O'Neill, Isabelle Pagé, Steven Passmore, Stephen M Perle, Jeffrey Quon, Mana Rezai, Maja Stupar, Michael Swain, Andrew Vitiello, Kenneth Weber, Kenneth J Young, Hainan Yu
BACKGROUND: A small proportion of chiropractors, osteopaths, and other manual medicine providers use spinal manipulative therapy (SMT) to manage non-musculoskeletal disorders. However, the efficacy and effectiveness of these interventions to prevent or treat non-musculoskeletal disorders remain controversial. OBJECTIVES: We convened a Global Summit of international scientists to conduct a systematic review of the literature to determine the efficacy and effectiveness of SMT for the primary, secondary and tertiary prevention of non-musculoskeletal disorders...
February 17, 2021: Chiropractic & Manual Therapies
#28
JOURNAL ARTICLE
Carlos E Rodríguez-Martínez, Monica P Sossa-Briceño, Ian P Sinha
OBJECTIVE: Although valved spacers are the preferred method for administering metered-dose inhaler bronchodilators such as albuterol in pediatric acute asthma, their high cost and their lack of availability have limited their use, especially in low- and middle-income countries (LMICs). Because of this, it is a common practice to use home-made spacers, although a formal analysis evaluating their cost-effectiveness is lacking. Therefore, the objective of this study was to analyze the cost-effectiveness of home-made spacers compared to commercial valved spacers for delivering bronchodilator therapy in pediatric acute asthma...
October 2021: Journal of Asthma
#29
JOURNAL ARTICLE
Daniel Garagorri-Gutiérrez, Raquel Leirós-Rodríguez
Background : Bronchial asthma is a chronic inflammatory disease of the respiratory tract. Its physiotherapy treatment aims to reduce the frequency of asthmatic spells and the intensity of symptoms. The methods employed act mainly through the education of the patient in the correct handling of the asthma attacks and the improvement of the pulmonary elasticity. Objective : The objective of this review was to critically evaluate the available evidence on the effectiveness of different physiotherapy interventions in asthmatic patients...
April 2022: Physiotherapy Theory and Practice
#30
JOURNAL ARTICLE
Vinayak Swarnkar, Udantha Abeyratne, Jamie Tan, Ti Wan Ng, Joanna M Brisbane, Jennifer Choveaux, Paul Porter
Introduction: Asthma is a common childhood respiratory disorder characterized by wheeze, cough and respiratory distress responsive to bronchodilator therapy. Asthma severity can be determined by subjective, manual scoring systems such as the Pulmonary Score (PS). These systems require significant medical training and expertise to rate clinical findings such as wheeze characteristics, and work of breathing. In this study, we report the development of an objective method of assessing acute asthma severity based on the automated analysis of cough sounds...
February 2021: Journal of Asthma
#31
JOURNAL ARTICLE
Femke Driehuis, Thomas J Hoogeboom, Maria W G Nijhuis-van der Sanden, Rob A de Bie, J Bart Staal
BACKGROUND: Studies on effectiveness and safety of specific spinal manual therapy (SMT) techniques in children, which distinguish between age groups, are lacking. OBJECTIVE: To conduct a systematic review of the evidence for effectiveness and harms of specific SMT techniques for infants, children and adolescents. METHODS: PubMed, Index to Chiropractic Literature, Embase, CINAHL and Cochrane Library were searched up to December 2017. Controlled studies, describing primary SMT treatment in infants (<1 year) and children/adolescents (1-18 years), were included to determine effectiveness...
2019: PloS One
#32
COMPARATIVE STUDY
Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño, Jose A Castro-Rodriguez
Objective: Although the efficacy of systemic corticosteroids (SCs) in acute asthma exacerbations is well established, the fact that many children still require admission to hospital and that SCs have a slow onset of action are cause of concern. For this reason, the use of inhaled corticosteroids (ICS) as a therapy added to SCs has been explored, with no clarity about its cost-effectiveness. The aim of the present study was to evaluate the cost-effectiveness of ICS in addition to SCs (ICS + SCs) compared to standard therapy with SCs for treating pediatric asthma exacerbations...
September 2020: Journal of Asthma
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JOURNAL ARTICLE
Gopalsamy Rajiv Gandhi, Alan Bruno Silva Vasconcelos, Govindasamy Hari Haran, Valdete Kaliane da Silva Calisto, Gnanasekaran Jothi, Jullyana de Souza Siqueira Quintans, Luis Eduardo Cuevas, Narendra Narain, Lucindo José Quintans Júnior, Rosana Cipolotti, Ricardo Queiroz Gurgel
BACKGROUND: Asthma, the main inflammatory chronic condition affecting the respiratory system, is characterized by hyperresponsiveness and reversible airway obstruction, recruitment of inflammatory cells and excessive production of mucus. Cytokines as biochemical messengers of immune cells, play an important role in the regulation of allergic inflammatory and infectious airway processes. Essential oils of plant origin are complex mixtures of volatile and semi volatile organic compounds that determine the specific aroma of plants and are categorized by their biological activities...
July 15, 2020: Phytomedicine
#34
JOURNAL ARTICLE
Carol Parnell Prevost, Brian Gleberzon, Beth Carleo, Kristian Anderson, Morgan Cark, Katherine A Pohlman
BACKGROUND: This systematic review evaluates the use of manual therapy for clinical conditions in the pediatric population, assesses the methodological quality of the studies found, and synthesizes findings based on health condition. We also assessed the reporting of adverse events within the included studies and compared our conclusions to those of the UK Update report. METHODS: Six databases were searched using the following inclusion criteria: children under the age of 18 years old; treatment using manual therapy; any type of healthcare profession; published between 2001 and March 31, 2018; and English...
March 13, 2019: BMC Complementary and Alternative Medicine
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JOURNAL ARTICLE
Salman Sadullah Usmani, Piyush Agrawal, Manika Sehgal, Pradeep Kumar Patel, Gajendra P S Raghava
Immunosuppression proved as a captivating therapy in several autoimmune disorders, asthma as well as in organ transplantation. Immunosuppressive peptides are specific for reducing efficacy of immune system with wide range of therapeutic implementations. `ImmunoSPdb' is a comprehensive, manually curated database of around 500 experimentally verified immunosuppressive peptides compiled from 79 research article and 32 patents. The current version comprises of 553 entries providing extensive information including peptide name, sequence, chirality, chemical modification, origin, nature of peptide, its target as well as mechanism of action, amino acid frequency and composition, etc...
January 1, 2019: Database: the Journal of Biological Databases and Curation
#36
JOURNAL ARTICLE
Jessica Castner, Manoj J Mammen, Carla R Jungquist, Olivia Licata, John J Pender, Gregory E Wilding, Sanjay Sethi
OBJECTIVE: Nighttime wakening with asthma symptoms is a key to assessment and therapy decisions, with no gold standard objective measure. The study aims were to (1) determine the feasibility, (2) explore equivalence, and (3) test concordance of a consumer-based accelerometer with standard actigraphy for measurement of sleep patterns in women with asthma as an adjunct to self-report. METHODS: Panel study design of women with poorly controlled asthma from a university-affiliated primary care clinic system was used...
July 2019: Journal of Asthma
#37
RANDOMIZED CONTROLLED TRIAL
Ibai López-de-Uralde-Villanueva, Pablo Candelas-Fernández, Beatriz de-Diego-Cano, Orcález Mínguez-Calzada, Tamara Del Corral
OBJECTIVE: The objective of this study was to evaluate whether the addition of manual therapy and therapeutic exercise protocol to inspiratory muscle training was more effective in improving maximum inspiratory pressure than inspiratory muscle training in isolation. DESIGN: This is a single-blinded, randomized controlled trial. SUBJECTS: In total, 43 patients with asthma were included in this study. INTERVENTIONS: The patients were allocated into one of the two groups: (1) inspiratory muscle training ( n = 21; 20-minute session) or (2) inspiratory muscle training (20-minute session) combined with a program of manual therapy (15-minute session) and therapeutic exercise (15-minute session; n = 22)...
June 2018: Clinical Rehabilitation
#38
JOURNAL ARTICLE
Kristine Desager, Françoise Vermeulen, Eddy Bodart
OBJECTIVES: We provide a narrative literature review on surveys used to assess the level of medication adherence in children and adolescents with asthma, the attitudes of these patients and their parents toward asthma therapy, and their expectations concerning asthma and available treatment. METHODS: A PubMed search and manual selection of the retrieved papers was conducted to identify studies using surveys or interviews that addressed one of the three topics of interest...
October 2018: Acta Clinica Belgica
#39
JOURNAL ARTICLE
Eleni Pateraki, Paul Graham Morris
OBJECTIVE: Asthma and anxiety are known to interact, leading to exacerbations for both conditions. This systematic review summarised evidence regarding the effectiveness of cognitive behavioural therapy (CBT) in reducing anxiety in individuals with asthma, with results presented separately for adults and children. DATA SOURCES: PRISMA and CRD guidance were followed to conduct and report the current review. Three major electronic databases (Ovid Medline, PsycINFO, and EMBASE) and manual searches were used to find relevant published and unpublished research...
May 2018: Journal of Asthma
#40
REVIEW
Paola Rogliani, Luigino Calzetta, Angelo Coppola, Francesco Cavalli, Josuel Ora, Ermanno Puxeddu, Maria Gabriella Matera, Mario Cazzola
Inhaled medication is the cornerstone of the pharmacological treatment for patients with asthma and chronic obstructive pulmonary disease (COPD). Several inhaler devices exist, and each device has specific characteristics to achieve the optimal inhalation of drugs. The correct use of inhaler devices is not granted and patients may incur in mistakes when using pressurized metered-dose inhalers (pMDIs) or dry-powder inhaler (DPIs). The incorrect use of inhaler devices can lead to a poorly controlled disease status...
March 2017: Respiratory Medicine
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