keyword
https://read.qxmd.com/read/38625641/silibinin-solubilization-combined-effect-of-co-solvency-and-inclusion-complex-formation
#21
JOURNAL ARTICLE
Azam Dehghan, Saeed Ghanbarzadeh, Majid Ghiass, Mohammad Imani
Objective: Belonging to the class II drugs according to the biopharmaceutics classification system, silibinin (SLB) benefits from high permeability but suffers poor solubility that negatively affects the development of any delivery system. This research aimed to improve SLB solubility by combined use of co-solvency and complexation phenomena. Methods: Solubility studies were performed using the phase solubility analysis according to the shake-flask method in the presence of ethanol and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) as a co-solvent and inclusion complexing agent, respectively...
April 16, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38624234/iron-starvation-increases-the-production-of-the-pseudomonas-aeruginosa-rsmy-and-rsmz-srnas-in-static-conditions
#22
JOURNAL ARTICLE
Rhishita Chourashi, Amanda G Oglesby
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that induces virulence gene expression in response to host-mediated iron starvation. Recently, our laboratory showed that some virulence factors are responsive to iron limitation in static but not shaking growth conditions. One of these is the HSI-2-type six secretion system (T6SS), which is also induced during chronic infection. Iron regulation of T6SS was partially impacted by the iron-responsive PrrF sRNA and completely dependent upon the Pseudomonas quinolone signal (PQS) biosynthetic gene pqsA ...
April 16, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38622596/optimizing-microbioreactor-cultivation-strategies-for-trichoderma-reesei-from-batch-to-fed-batch-operations
#23
JOURNAL ARTICLE
Katja Rohr, Lisa Gremm, Bertram Geinitz, Etienne Jourdier, Wolfgang Wiechert, Fadhel Ben Chaabane, Marco Oldiges
BACKGROUND: Filamentous fungi have long been recognized for their exceptional enzyme production capabilities. Among these, Trichoderma reesei has emerged as a key producer of various industrially relevant enzymes and is particularly known for the production of cellulases. Despite the availability of advanced gene editing techniques for T. reesei, the cultivation and characterization of resulting strain libraries remain challenging, necessitating well-defined and controlled conditions with higher throughput...
April 15, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38622481/leaching-approach-for-%C3%AE-glucosidase-extraction-from-fermented-rice-husk-in-solid-state-cultivation-by-aspergillus-protuberus
#24
JOURNAL ARTICLE
P Suresh Yadav, B V Siva Prasad, M Subhosh Chandra, Naga Raju Maddela, Ram Prasad
Environmental problems are caused by the disposal of agrowastes in developing countries. It is imperative to convert such wastes into useful products, which require enzymes such as β-glucosidase. β-Glucosidase has variety of applications in biotechnology including food, textile, detergents, pulp and paper, pharmaceutical and biofuel industries. β-Glucosidase production was performed using the locally isolated Aspergillus protuberus using best growth circumstances on rice husk in solid-state fermentation (SSF)...
April 15, 2024: Current Microbiology
https://read.qxmd.com/read/38614199/statistical-optimized-production-of-phytase-from-hanseniaspora-guilliermondii-s1-and-studies-on-purification-homology-modelling-and-growth-promotion-effect
#25
JOURNAL ARTICLE
Mathiyazhagan Narayanan, K Suresh, Sami Al Obaid, Parameswari Alagarsamy, Cong-Kinh Nguyen
This investigation was performed to obtain a promising phytase enzyme producing yeast. In this regard, the PSM was used to isolate the phytase-producing Hanseniaspora guilliermondii S1 (MG663578) from sugarcane juice. The SSF optimum conditions for phytase generation were optimized using (OVAT) one-variable-at-a-time strategy using both Box-Behnken design and shake flask method (g/100ml: 0.05 yeast extract, 0.15 Peptone, 0.05 malt extract 0.50 dextrose, pH 5.8 and 28ᵒC). The protein model developed was shown to be adequate for phytase production (91% accuracy), with the greatest phytase productivity in shake flask with substrate jack fruit seed powder being 395± 0...
April 11, 2024: Environmental Research
https://read.qxmd.com/read/38613283/study-of-high-transverse-momentum-higgs-boson-production-in-association-with-a-vector-boson-in-the-qqbb-final-state-with-the-atlas-detector
#26
JOURNAL ARTICLE
G Aad, B Abbott, K Abeling, N J Abicht, S H Abidi, A Aboulhorma, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, C Adam Bourdarios, L Adamczyk, S V Addepalli, M J Addison, J Adelman, A Adiguzel, T Adye, A A Affolder, Y Afik, M N Agaras, J Agarwala, A Aggarwal, C Agheorghiesei, A Ahmad, F Ahmadov, W S Ahmed, S Ahuja, X Ai, G Aielli, A Aikot, M Ait Tamlihat, B Aitbenchikh, I Aizenberg, M Akbiyik, T P A Åkesson, A V Akimov, D Akiyama, N N Akolkar, S Aktas, K Al Khoury, G L Alberghi, J Albert, P Albicocco, G L Albouy, S Alderweireldt, Z L Alegria, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, F Alfonsi, M Algren, M Alhroob, B Ali, H M J Ali, S Ali, S W Alibocus, M Aliev, G Alimonti, W Alkakhi, C Allaire, B M M Allbrooke, J F Allen, C A Allendes Flores, P P Allport, A Aloisio, F Alonso, C Alpigiani, M Alvarez Estevez, A Alvarez Fernandez, M Alves Cardoso, M G Alviggi, M Aly, Y Amaral Coutinho, A Ambler, C Amelung, M Amerl, C G Ames, D Amidei, S P Amor Dos Santos, K R Amos, V Ananiev, C Anastopoulos, T Andeen, J K Anders, S Y Andrean, A Andreazza, S Angelidakis, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, E Antipov, M Antonelli, F Anulli, M Aoki, T Aoki, J A Aparisi Pozo, M A Aparo, L Aperio Bella, C Appelt, A Apyan, N Aranzabal, S J Arbiol Val, C Arcangeletti, A T H Arce, E Arena, J-F Arguin, S Argyropoulos, J-H Arling, O Arnaez, H Arnold, G Artoni, H Asada, K Asai, S Asai, N A Asbah, K Assamagan, R Astalos, S Atashi, R J Atkin, M Atkinson, H Atmani, P A Atmasiddha, K Augsten, S Auricchio, A D Auriol, V A Austrup, G Avolio, K Axiotis, G Azuelos, D Babal, H Bachacou, K Bachas, A Bachiu, F Backman, A Badea, T M Baer, P Bagnaia, M Bahmani, D Bahner, A J Bailey, V R Bailey, J T Baines, L Baines, O K Baker, E Bakos, D Bakshi Gupta, V Balakrishnan, R Balasubramanian, E M Baldin, P Balek, E Ballabene, F Balli, L M Baltes, W K Balunas, J Balz, E Banas, M Bandieramonte, A Bandyopadhyay, S Bansal, L Barak, M Barakat, E L Barberio, D Barberis, M Barbero, M Z Barel, K N Barends, T Barillari, M-S Barisits, T Barklow, P Baron, D A Baron Moreno, A Baroncelli, G Barone, A J Barr, J D Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, U Barron, M G Barros Teixeira, S Barsov, F Bartels, R Bartoldus, A E Barton, P Bartos, A Basan, M Baselga, A Bassalat, M J Basso, C R Basson, R L Bates, S Batlamous, J R Batley, B Batool, M Battaglia, D Battulga, M Bauce, M Bauer, P Bauer, L T Bazzano Hurrell, J B Beacham, T Beau, J Y Beaucamp, P H Beauchemin, P Bechtle, H P Beck, K Becker, A J Beddall, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, J F Beirer, F Beisiegel, M Belfkir, G Bella, L Bellagamba, A Bellerive, P Bellos, K Beloborodov, D Benchekroun, F Bendebba, Y Benhammou, M Benoit, S Bentvelsen, L Beresford, M Beretta, E Bergeaas Kuutmann, N Berger, B Bergmann, J Beringer, G Bernardi, C Bernius, F U Bernlochner, F Bernon, A Berrocal Guardia, T Berry, P Berta, A Berthold, I A Bertram, S Bethke, A Betti, A J Bevan, N K Bhalla, M Bhamjee, S Bhatta, D S Bhattacharya, P Bhattarai, V S Bhopatkar, R Bi, R M Bianchi, G Bianco, O Biebel, R Bielski, M Biglietti, M Bindi, A Bingul, C Bini, A Biondini, C J Birch-Sykes, G A Bird, M Birman, M Biros, S Biryukov, T Bisanz, E Bisceglie, J P Biswal, D Biswas, A Bitadze, K Bjørke, I Bloch, A Blue, U Blumenschein, J Blumenthal, G J Bobbink, V S Bobrovnikov, M Boehler, B Boehm, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, M Bomben, M Bona, M Boonekamp, C D Booth, A G Borbély, I S Bordulev, H M Borecka-Bielska, G Borissov, D Bortoletto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, N Bouchhar, J Boudreau, E V Bouhova-Thacker, D Boumediene, R Bouquet, A Boveia, J Boyd, D Boye, I R Boyko, J Bracinik, N Brahimi, G Brandt, O Brandt, F Braren, B Brau, J E Brau, R Brener, L Brenner, R Brenner, S Bressler, D Britton, D Britzger, I Brock, G Brooijmans, W K Brooks, E Brost, L M Brown, L E Bruce, T L Bruckler, P A Bruckman de Renstrom, B Brüers, A Bruni, G Bruni, M Bruschi, N Bruscino, T Buanes, Q Buat, D Buchin, A G Buckley, O Bulekov, B A Bullard, S Burdin, C D Burgard, A M Burger, B Burghgrave, O Burlayenko, J T P Burr, C D Burton, J C Burzynski, E L Busch, V Büscher, P J Bussey, J M Butler, C M Buttar, J M Butterworth, W Buttinger, C J Buxo Vazquez, A R Buzykaev, S Cabrera Urbán, L Cadamuro, D Caforio, H Cai, Y Cai, Y Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, G Calderini, P Calfayan, G Callea, L P Caloba, D Calvet, S Calvet, M Calvetti, R Camacho Toro, S Camarda, D Camarero Munoz, P Camarri, M T Camerlingo, D Cameron, C Camincher, M Campanelli, A Camplani, V Canale, A Canesse, J Cantero, Y Cao, F Capocasa, M Capua, A Carbone, R Cardarelli, J C J Cardenas, F Cardillo, G Carducci, T Carli, G Carlino, J I Carlotto, B T Carlson, E M Carlson, L Carminati, A Carnelli, M Carnesale, S Caron, E Carquin, S Carrá, G Carratta, F Carrio Argos, J W S Carter, T M Carter, M P Casado, M Caspar, F L Castillo, L Castillo Garcia, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, V Cavaliere, N Cavalli, V Cavasinni, Y C Cekmecelioglu, E Celebi, F Celli, M S Centonze, V Cepaitis, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, B Cervato, A Cervelli, G Cesarini, S A Cetin, D Chakraborty, J Chan, W Y Chan, J D Chapman, E Chapon, B Chargeishvili, D G Charlton, M Chatterjee, C Chauhan, S Chekanov, S V Chekulaev, G A Chelkov, A Chen, B Chen, B Chen, H Chen, H Chen, J Chen, J Chen, M Chen, S Chen, S J Chen, X Chen, X Chen, Y Chen, C L Cheng, H C Cheng, S Cheong, A Cheplakov, E Cheremushkina, E Cherepanova, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, N Chiedde, G Chiodini, A S Chisholm, A Chitan, M Chitishvili, M V Chizhov, K Choi, A R Chomont, Y Chou, E Y S Chow, T Chowdhury, K L Chu, M C Chu, X Chu, J Chudoba, J J Chwastowski, D Cieri, K M Ciesla, V Cindro, A Ciocio, F Cirotto, Z H Citron, M Citterio, D A Ciubotaru, A Clark, P J Clark, C Clarry, J M Clavijo Columbie, S E Clawson, C Clement, J Clercx, Y Coadou, M Cobal, A Coccaro, R F Coelho Barrue, R Coelho Lopes De Sa, S Coelli, A E C Coimbra, B Cole, J Collot, P Conde Muiño, M P Connell, S H Connell, I A Connelly, E I Conroy, F Conventi, H G Cooke, A M Cooper-Sarkar, A Cordeiro Oudot Choi, L D Corpe, M Corradi, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, B M Cote, G Cowan, K Cranmer, D Cremonini, S Crépé-Renaudin, F Crescioli, M Cristinziani, M Cristoforetti, V Croft, J E Crosby, G Crosetti, A Cueto, T Cuhadar Donszelmann, H Cui, Z Cui, W R Cunningham, F Curcio, P Czodrowski, M M Czurylo, M J Da Cunha Sargedas De Sousa, J V Da Fonseca Pinto, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, D Dal Santo, C Dallapiccola, M Dam, G D'amen, V D'Amico, J Damp, J R Dandoy, M Danninger, V Dao, G Darbo, S Darmora, S J Das, S D'Auria, C David, T Davidek, B Davis-Purcell, I Dawson, H A Day-Hall, K De, R De Asmundis, N De Biase, S De Castro, N De Groot, P de Jong, H De la Torre, A De Maria, A De Salvo, U De Sanctis, F De Santis, A De Santo, J B De Vivie De Regie, D V Dedovich, J Degens, A M Deiana, F Del Corso, J Del Peso, F Del Rio, L Delagrange, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, P A Delsart, S Demers, M Demichev, S P Denisov, L D'Eramo, D Derendarz, F Derue, P Dervan, K Desch, C Deutsch, F A Di Bello, A Di Ciaccio, L Di Ciaccio, A Di Domenico, C Di Donato, A Di Girolamo, G Di Gregorio, A Di Luca, B Di Micco, R Di Nardo, C Diaconu, M Diamantopoulou, F A Dias, T Dias Do Vale, M A Diaz, F G Diaz Capriles, M Didenko, E B Diehl, L Diehl, S Díez Cornell, C Diez Pardos, C Dimitriadi, A Dimitrievska, J Dingfelder, I-M Dinu, S J Dittmeier, F Dittus, F Djama, T Djobava, C Doglioni, A Dohnalova, J Dolejsi, Z Dolezal, K M Dona, M Donadelli, B Dong, J Donini, A D'Onofrio, M D'Onofrio, J Dopke, A Doria, N Dos Santos Fernandes, P Dougan, M T Dova, A T Doyle, M A Draguet, E Dreyer, I Drivas-Koulouris, M Drnevich, A S Drobac, M Drozdova, D Du, T A du Pree, F Dubinin, M Dubovsky, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, E R Duden, M D'uffizi, L Duflot, M Dührssen, A E Dumitriu, M Dunford, S Dungs, K Dunne, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, B L Dwyer, G I Dyckes, M Dyndal, B S Dziedzic, Z O Earnshaw, G H Eberwein, B Eckerova, S Eggebrecht, E Egidio Purcino De Souza, L F Ehrke, G Eigen, K Einsweiler, T Ekelof, P A Ekman, S El Farkh, Y El Ghazali, H El Jarrari, A El Moussaouy, V Ellajosyula, M Ellert, F Ellinghaus, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, I Ene, S Epari, P A Erland, M Errenst, M Escalier, C Escobar, E Etzion, G Evans, H Evans, L S Evans, M O Evans, A Ezhilov, S Ezzarqtouni, F Fabbri, L Fabbri, G Facini, V Fadeyev, R M Fakhrutdinov, D Fakoudis, S Falciano, L F Falda Ulhoa Coelho, P J Falke, J Faltova, C Fan, Y Fan, Y Fang, M Fanti, M Faraj, Z Farazpay, A Farbin, A Farilla, T Farooque, S M Farrington, F Fassi, D Fassouliotis, M Faucci Giannelli, W J Fawcett, L Fayard, P Federic, P Federicova, O L Fedin, G Fedotov, M Feickert, L Feligioni, D E Fellers, C Feng, M Feng, Z Feng, M J Fenton, A B Fenyuk, L Ferencz, R A M Ferguson, S I Fernandez Luengo, P Fernandez Martinez, M J V Fernoux, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D Ferrere, C Ferretti, F Fiedler, P Fiedler, A Filipčič, E K Filmer, F Filthaut, M C N Fiolhais, L Fiorini, W C Fisher, T Fitschen, P M Fitzhugh, I Fleck, P Fleischmann, T Flick, M Flores, L R Flores Castillo, L Flores Sanz De Acedo, F M Follega, N Fomin, J H Foo, A Formica, A C Forti, E Fortin, A W Fortman, M G Foti, L Fountas, D Fournier, H Fox, P Francavilla, S Francescato, S Franchellucci, M Franchini, S Franchino, D Francis, L Franco, V Franco Lima, L Franconi, M Franklin, G Frattari, A C Freegard, W S Freund, Y Y Frid, J Friend, N Fritzsche, A Froch, D Froidevaux, J A Frost, Y Fu, S Fuenzalida Garrido, M Fujimoto, K Y Fung, E Furtado De Simas Filho, M Furukawa, J Fuster, A Gabrielli, A Gabrielli, P Gadow, G Gagliardi, L G Gagnon, E J Gallas, B J Gallop, K K Gan, S Ganguly, Y Gao, F M Garay Walls, B Garcia, C García, A Garcia Alonso, A G Garcia Caffaro, J E García Navarro, M Garcia-Sciveres, G L Gardner, R W Gardner, N Garelli, D Garg, R B Garg, J M Gargan, C A Garner, C M Garvey, P Gaspar, V K Gassmann, G Gaudio, V Gautam, P Gauzzi, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, A A Geanta, C M Gee, A Gekow, C Gemme, M H Genest, S Gentile, A D Gentry, S George, W F George, T Geralis, P Gessinger-Befurt, M E Geyik, M Ghani, M Ghneimat, K Ghorbanian, A Ghosal, A Ghosh, A Ghosh, B Giacobbe, S Giagu, T Giani, P Giannetti, A Giannini, S M Gibson, M Gignac, D T Gil, A K Gilbert, B J Gilbert, D Gillberg, G Gilles, N E K Gillwald, L Ginabat, D M Gingrich, M P Giordani, P F Giraud, G Giugliarelli, D Giugni, F Giuli, I Gkialas, L K Gladilin, C Glasman, G R Gledhill, G Glemža, M Glisic, I Gnesi, Y Go, M Goblirsch-Kolb, B Gocke, D Godin, B Gokturk, S Goldfarb, T Golling, M G D Gololo, D Golubkov, J P Gombas, A Gomes, G Gomes Da Silva, A J Gomez Delegido, R Gonçalo, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, R Y González Andana, S González de la Hoz, R Gonzalez Lopez, C Gonzalez Renteria, M V Gonzalez Rodrigues, R Gonzalez Suarez, S Gonzalez-Sevilla, G R Gonzalvo Rodriguez, L Goossens, B Gorini, E Gorini, A Gorišek, T C Gosart, A T Goshaw, M I Gostkin, S Goswami, C A Gottardo, S A Gotz, M Gouighri, V Goumarre, A G Goussiou, N Govender, I Grabowska-Bold, K Graham, E Gramstad, S Grancagnolo, M Grandi, C M Grant, P M Gravila, F G Gravili, H M Gray, M Greco, C Grefe, I M Gregor, P Grenier, S G Grewe, C Grieco, A A Grillo, K Grimm, S Grinstein, J-F Grivaz, E Gross, J Grosse-Knetter, C Grud, J C Grundy, L Guan, W Guan, C Gubbels, J G R Guerrero Rojas, G Guerrieri, F Guescini, R Gugel, J A M Guhit, A Guida, E Guilloton, S Guindon, F Guo, J Guo, L Guo, Y Guo, R Gupta, R Gupta, S Gurbuz, S S Gurdasani, G Gustavino, M Guth, P Gutierrez, L F Gutierrez Zagazeta, M Gutsche, C Gutschow, C Gwenlan, C B Gwilliam, E S Haaland, A Haas, M Habedank, C Haber, H K Hadavand, A Hadef, S Hadzic, A I Hagan, J J Hahn, E H Haines, M Haleem, J Haley, J J Hall, G D Hallewell, L Halser, K Hamano, M Hamer, G N Hamity, E J Hampshire, J Han, K Han, L Han, L Han, S Han, Y F Han, K Hanagaki, M Hance, D A Hangal, H Hanif, M D Hank, J B Hansen, P H Hansen, K Hara, D Harada, T Harenberg, S Harkusha, M L Harris, Y T Harris, J Harrison, N M Harrison, P F Harrison, N M Hartman, N M Hartmann, Y Hasegawa, R Hauser, C M Hawkes, R J Hawkings, Y Hayashi, S Hayashida, D Hayden, C Hayes, R L Hayes, C P Hays, J M Hays, H S Hayward, F He, M He, Y He, Y He, N B Heatley, V Hedberg, A L Heggelund, N D Hehir, C Heidegger, K K Heidegger, W D Heidorn, J Heilman, S Heim, T Heim, J G Heinlein, J J Heinrich, L Heinrich, J Hejbal, L Helary, A Held, S Hellesund, C M Helling, S Hellman, R C W Henderson, L Henkelmann, A M Henriques Correia, H Herde, Y Hernández Jiménez, L M Herrmann, T Herrmann, G Herten, R Hertenberger, L Hervas, M E Hesping, N P Hessey, H Hibi, E Hill, S J Hillier, J R Hinds, F Hinterkeuser, M Hirose, S Hirose, D Hirschbuehl, T G Hitchings, B Hiti, J Hobbs, R Hobincu, N Hod, M C Hodgkinson, B H Hodkinson, A Hoecker, D D Hofer, J Hofer, T Holm, M Holzbock, L B A H Hommels, B P Honan, J Hong, T M Hong, B H Hooberman, W H Hopkins, Y Horii, S Hou, A S Howard, J Howarth, J Hoya, M Hrabovsky, A Hrynevich, T Hryn'ova, P J Hsu, S-C Hsu, Q Hu, Y F Hu, S Huang, X Huang, X Huang, Y Huang, Y Huang, Z Huang, Z Hubacek, M Huebner, F Huegging, T B Huffman, C A Hugli, M Huhtinen, S K Huiberts, R Hulsken, N Huseynov, J Huston, J Huth, R Hyneman, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, J P Iddon, P Iengo, R Iguchi, T Iizawa, Y Ikegami, N Ilic, H Imam, M Ince Lezki, T Ingebretsen Carlson, G Introzzi, M Iodice, V Ippolito, R K Irwin, M Ishino, W Islam, C Issever, S Istin, H Ito, J M Iturbe Ponce, R Iuppa, A Ivina, J M Izen, V Izzo, P Jacka, P Jackson, R M Jacobs, B P Jaeger, C S Jagfeld, G Jain, P Jain, K Jakobs, T Jakoubek, J Jamieson, K W Janas, M Javurkova, F Jeanneau, L Jeanty, J Jejelava, P Jenni, C E Jessiman, S Jézéquel, C Jia, J Jia, X Jia, X Jia, Z Jia, S Jiggins, J Jimenez Pena, S Jin, A Jinaru, O Jinnouchi, P Johansson, K A Johns, J W Johnson, D M Jones, E Jones, P Jones, R W L Jones, T J Jones, H L Joos, R Joshi, J Jovicevic, X Ju, J J Junggeburth, T Junkermann, A Juste Rozas, M K Juzek, S Kabana, A Kaczmarska, M Kado, H Kagan, M Kagan, A Kahn, A Kahn, C Kahra, T Kaji, E Kajomovitz, N Kakati, I Kalaitzidou, C W Kalderon, A Kamenshchikov, N J Kang, D Kar, K Karava, M J Kareem, E Karentzos, I Karkanias, O Karkout, S N Karpov, Z M Karpova, V Kartvelishvili, A N Karyukhin, E Kasimi, J Katzy, S Kaur, K Kawade, M P Kawale, C Kawamoto, T Kawamoto, E F Kay, F I Kaya, S Kazakos, V F Kazanin, Y Ke, J M Keaveney, R Keeler, G V Kehris, J S Keller, A S Kelly, J J Kempster, K E Kennedy, P D Kennedy, O Kepka, B P Kerridge, S Kersten, B P Kerševan, S Keshri, L Keszeghova, S Ketabchi Haghighat, R A Khan, A Khanov, A G Kharlamov, T Kharlamova, E E Khoda, M Kholodenko, T J Khoo, G Khoriauli, J Khubua, Y A R Khwaira, A Kilgallon, D W Kim, Y K Kim, N Kimura, M K Kingston, A Kirchhoff, C Kirfel, F Kirfel, J Kirk, A E Kiryunin, C Kitsaki, O Kivernyk, M Klassen, C Klein, L Klein, M H Klein, M Klein, S B Klein, U Klein, P Klimek, A Klimentov, T Klioutchnikova, P Kluit, S Kluth, E Kneringer, T M Knight, A Knue, R Kobayashi, D Kobylianskii, S F Koch, M Kocian, P Kodyš, D M Koeck, P T Koenig, T Koffas, O Kolay, I Koletsou, T Komarek, K Köneke, A X Y Kong, T Kono, N Konstantinidis, P Kontaxakis, B Konya, R Kopeliansky, S Koperny, K Korcyl, K Kordas, A Korn, S Korn, I Korolkov, N Korotkova, B Kortman, O Kortner, S Kortner, W H Kostecka, V V Kostyukhin, A Kotsokechagia, A Kotwal, A Koulouris, A Kourkoumeli-Charalampidi, C Kourkoumelis, E Kourlitis, O Kovanda, R Kowalewski, W Kozanecki, A 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Undrus, G Unel, J Urban, P Urquijo, P Urrejola, G Usai, R Ushioda, M Usman, Z Uysal, V Vacek, B Vachon, K O H Vadla, T Vafeiadis, A Vaitkus, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, E Valiente Moreno, A Vallier, J A Valls Ferrer, D R Van Arneman, T R Van Daalen, A Van Der Graaf, P Van Gemmeren, M Van Rijnbach, S Van Stroud, I Van Vulpen, M Vanadia, W Vandelli, M Vandenbroucke, E R Vandewall, D Vannicola, L Vannoli, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, L Varriale, K E Varvell, M E Vasile, L Vaslin, G A Vasquez, A Vasyukov, F Vazeille, T Vazquez Schroeder, J Veatch, V Vecchio, M J Veen, I Veliscek, L M Veloce, F Veloso, S Veneziano, A Ventura, S Ventura Gonzalez, A Verbytskyi, M Verducci, C Vergis, M Verissimo De Araujo, W Verkerke, J C Vermeulen, C Vernieri, M Vessella, M C Vetterli, A Vgenopoulos, N Viaux Maira, T Vickey, O E Vickey Boeriu, G H A Viehhauser, L Vigani, M Villa, M Villaplana Perez, E M Villhauer, E Vilucchi, M G Vincter, G S Virdee, A Vishwakarma, A Visibile, C Vittori, I Vivarelli, E Voevodina, F Vogel, J C Voigt, P Vokac, Yu Volkotrub, J Von Ahnen, E Von Toerne, B Vormwald, V Vorobel, K Vorobev, M Vos, K Voss, J H Vossebeld, M Vozak, L Vozdecky, N Vranjes, M Vranjes Milosavljevic, M Vreeswijk, N K Vu, R Vuillermet, O Vujinovic, I Vukotic, S Wada, C Wagner, J M Wagner, W Wagner, S Wahdan, H Wahlberg, M Wakida, J Walder, R Walker, W Walkowiak, A Wall, T Wamorkar, A Z Wang, C Wang, C Wang, H Wang, J Wang, R-J Wang, R Wang, R Wang, S M Wang, S Wang, T Wang, W T Wang, W Wang, X Wang, X Wang, X Wang, Y Wang, Y Wang, Z Wang, Z Wang, Z Wang, A Warburton, R J Ward, N Warrack, S Waterhouse, A T Watson, H Watson, M F Watson, E Watton, G Watts, B M Waugh, C Weber, H A Weber, M S Weber, S M Weber, C Wei, Y Wei, A R Weidberg, E J Weik, J Weingarten, M Weirich, C Weiser, C J Wells, T Wenaus, B Wendland, T Wengler, N S Wenke, N Wermes, M Wessels, A M Wharton, A S White, A White, M J White, D Whiteson, L Wickremasinghe, W Wiedenmann, M Wielers, C Wiglesworth, D J Wilbern, H G Wilkens, D M Williams, H H Williams, S Williams, S Willocq, B J Wilson, P J Windischhofer, F I Winkel, F Winklmeier, B T Winter, J K Winter, M Wittgen, M Wobisch, Z Wolffs, J Wollrath, M W Wolter, H Wolters, A F Wongel, E L Woodward, S D Worm, B K Wosiek, K W Woźniak, S Wozniewski, K Wraight, C Wu, J Wu, M Wu, M Wu, S L Wu, X Wu, Y Wu, Z Wu, J Wuerzinger, T R Wyatt, B M Wynne, S Xella, L Xia, M Xia, J Xiang, M Xie, X Xie, S Xin, A Xiong, J Xiong, D Xu, H Xu, L Xu, R Xu, T Xu, Y Xu, Z Xu, Z Xu, B Yabsley, S Yacoob, Y Yamaguchi, E Yamashita, H Yamauchi, T Yamazaki, Y Yamazaki, J Yan, S Yan, Z Yan, H J Yang, H T Yang, S Yang, T Yang, X Yang, X Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, H Ye, H Ye, J Ye, S Ye, X Ye, Y Yeh, I Yeletskikh, B K Yeo, M R Yexley, P Yin, K Yorita, S Younas, C J S Young, C Young, C Yu, Y Yu, M Yuan, R Yuan, L Yue, M Zaazoua, B Zabinski, E Zaid, Z K Zak, T Zakareishvili, N Zakharchuk, S Zambito, J A Zamora Saa, J Zang, D Zanzi, O Zaplatilek, C Zeitnitz, H Zeng, J C Zeng, D T Zenger, O Zenin, T Ženiš, S Zenz, S Zerradi, D Zerwas, M Zhai, B Zhang, D F Zhang, J Zhang, J Zhang, K Zhang, L Zhang, P Zhang, R Zhang, S Zhang, S Zhang, T Zhang, X Zhang, X Zhang, Y Zhang, Y Zhang, Y Zhang, Z Zhang, Z Zhang, H Zhao, T Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zheng, K Zheng, X Zheng, Z Zheng, D Zhong, B Zhou, H Zhou, N Zhou, Y Zhou, Y Zhou, C G Zhu, J Zhu, Y Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, N I Zimine, J Zinsser, M Ziolkowski, L Živković, A Zoccoli, K Zoch, T G Zorbas, O Zormpa, W Zou, L Zwalinski
This Letter presents the first study of Higgs boson production in association with a vector boson (V=W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at sqrt[s]=13  TeV and corresponding to an integrated luminosity of 137  fb^{-1}. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb[over ¯]...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38610394/improving-optical-flow-sensor-using-a-gimbal-for-quadrotor-navigation-in-gps-denied-environment
#27
JOURNAL ARTICLE
Jonathan Flores, Ivan Gonzalez-Hernandez, Sergio Salazar, Rogelio Lozano, Christian Reyes
This paper proposes a new sensor using optical flow to stabilize a quadrotor when a GPS signal is not available. Normally, optical flow varies with the attitude of the aerial vehicle. This produces positive feedback on the attitude control that destabilizes the orientation of the vehicle. To avoid this, we propose a novel sensor using an optical flow camera with a 6DoF IMU (Inertial Measurement Unit) mounted on a two-axis anti-shake stabilizer mobile aerial gimbal. We also propose a robust algorithm based on Sliding Mode Control for stabilizing the optical flow sensor downwards independently of the aerial vehicle attitude...
March 28, 2024: Sensors
https://read.qxmd.com/read/38610252/sub-ppb-detection-with-gas-phase-multiphoton-electron-extraction-spectroscopy-under-ambient-conditions
#28
JOURNAL ARTICLE
Tikhon Filippov, Elena Vervitski, Hila Kofler, Lea Birkan, Shaked Levy, Shay Zimmerman, Valery Bulatov, Israel Schechter, Roman Schuetz
Multiphoton electron extraction spectroscopy (MEES) is an advanced analytical technique that has demonstrated exceptional sensitivity and specificity for detecting molecular traces on solid and liquid surfaces. Building upon the solid-state MEES foundations, this study introduces the first application of MEES in the gas phase (gas-phase MEES), specifically designed for quantitative detection of gas traces at sub-part per billion (sub-PPB) concentrations under ambient atmospheric conditions. Our experimental setup utilizes resonant multiphoton ionization processes using ns laser pulses under a high electrical field...
March 22, 2024: Sensors
https://read.qxmd.com/read/38608570/bioprocess-optimization-for-food-grade-cellulolytic-enzyme-production-from-sorghum-waste-in-a-novel-solid-state-fermentation-bioreactor-for-enhanced-apple-juice-clarification
#29
JOURNAL ARTICLE
Raikamal Bhattacharya, Sidharth Arora, Sanjoy Ghosh
Transforming global agricultural waste into eco-friendly products like industrial enzymes through bioconversion can help address sustainability challenges aligning with the United Nations' Sustainable Development Goals. Present study explored the production of high-yield food-grade cellulolytic enzymes from Trichoderma reesei MTCC 4876, using a novel media formulation with a combination of waste sorghum grass and cottonseed oil cake (3:1). Optimization of physical and environmental parameters, along with the screening and optimization of media components, led to an upscaled process in a novel 6-L solid-state fermentation (SSF)-packed bed reactor (PBR) with a substrate loading of 200 g...
April 10, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38607527/biosynthesis-optimization-of-antibacterial-magnetic-iron-oxide-nanoparticles-from-bacillus-megaterium
#30
JOURNAL ARTICLE
Sajedeh Hajiali, Sara Daneshjou, Somayeh Daneshjoo, Khosro Khajeh
The occurrence of antibiotic resistance on common bacterial agents and the need to use new generations of antibiotics have led to the use of various strategies for production. Taking inspiration from nature, using bio-imitation patterns, in addition to the low cost of production, is advantageous and highly accurate. In this research, we were able to control the temperature, shake, and synthesis time of the synthesis conditions of Bacillus megaterium bacteria as a model for the synthesis of magnetic iron nanoparticles and optimize the ratio of reducing salt to bacterial regenerating agents as well as the concentration of salt to create iron oxide nanoparticles with more favorable properties and produced with more antibacterial properties...
April 12, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38605135/spectral-characterization-of-the-impact-of-modifiers-and-different-prepare-temperatures-on-snow-lotus-medicinal-residue-biochar-and-dissolved-organic-matter
#31
JOURNAL ARTICLE
Sha Zhang, Zenghong Sun, Yanna Yao, Xinyu Wang, Shuge Tian
This study involved the production of 20 biochar samples derived from secondary medicinal residues of Snow Lotus Oral Liquid, processed within the temperature range of 200-600 °C. Additionally, four medicinal residues, including dissolved organic matter (DOM), from 24 samples obtained using the shaking method, served as the primary source material. The investigation focused on two key factors: the modifier and preparation temperature. These factors were examined to elucidate the spectral characteristics and chemical properties of the pharmaceutical residues, biochar, and DOM...
April 11, 2024: Scientific Reports
https://read.qxmd.com/read/38600640/development-and-validation-of-high-performance-liquid-chromatography-orbitrap-mass-spectrometric-method-for-quantification-of-ndma-in-ranitidine-drug-products-and-evaluation-of-antioxidants-as-inhibitors-of-classical-nitrosation-reaction
#32
JOURNAL ARTICLE
Dande Aishwarya, Pallaprolu Nikhil, Subramanian Natesan, Ravichandiran Velayutham, Ramalingam Peraman
RATIONALE: N-Nitroso dimethylamine (NDMA) is a mutagenic impurity detected in several ranitidine products. The amino functional group of ranitidine is a risk factor for classical nitrosation-induced NDMA formation in ranitidine drug products during storage conditions. The United States Food and Drug Administration (US FDA) recommended the use of antioxidants to control NDMA in drug products. Considering the need for sensitive analytics, a liquid chromatography/high-resolution mass spectrometry (LC-HRMS) method was developed and validated to detect NDMA in this pilot study to demonstrate the antioxidants as inhibitors of nitrosation reactions...
June 15, 2024: Rapid Communications in Mass Spectrometry: RCM
https://read.qxmd.com/read/38594681/droplet-based-microfluidic-platform-for-detecting-agonistic-peptides-that-are-self-secreted-by-yeast-expressing-a-g-protein-coupled-receptor
#33
JOURNAL ARTICLE
Ririka Asama, Cher J S Liu, Masahiro Tominaga, Yu-Ru Cheng, Yasuyuki Nakamura, Akihiko Kondo, Hsiang-Yu Wang, Jun Ishii
BACKGROUND: Single-cell droplet microfluidics is an important platform for high-throughput analyses and screening because it provides an independent and compartmentalized microenvironment for reaction or cultivation by coencapsulating individual cells with various molecules in monodisperse microdroplets. In combination with microbial biosensors, this technology becomes a potent tool for the screening of mutant strains. In this study, we demonstrated that a genetically engineered yeast strain that can fluorescently sense agonist ligands via the heterologous expression of a human G-protein-coupled receptor (GPCR) and concurrently secrete candidate peptides is highly compatible with single-cell droplet microfluidic technology for the high-throughput screening of new agonistically active peptides...
April 9, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38590970/embodied-visible-and-courteous-exploring-robotic-social-touch-with-virtual-idols
#34
JOURNAL ARTICLE
Yuya Onishi, Kosuke Ogawa, Kazuaki Tanaka, Hideyuki Nakanishi
In recent years, virtual idols have garnered considerable attention because they can perform activities similar to real idols. However, as they are fictitious idols with nonphysical presence, they cannot perform physical interactions such as handshake. Combining a robotic hand with a display showing virtual idols is the one of the methods to solve this problem. Nonetheless a physical handshake is possible, the form of handshake that can effectively induce the desirable behavior is unclear. In this study, we adopted a robotic hand as an interface and aimed to imitate the behavior of real idols...
2024: Frontiers in Robotics and AI
https://read.qxmd.com/read/38585708/improving-product-quality-and-productivity-of-an-antibody-based-biotherapeutic-using-inverted-frustoconical-shaking-bioreactors
#35
JOURNAL ARTICLE
Xuekun Wang, Jin Xu, Qingcheng Guo, Zhenhua Li, Jiawei Cao, Rongrong Fu, Mengjiao Xu, Xiang Zhao, Fugui Wang, Xinmeng Zhang, Taimin Dong, Xu Li, Weizhu Qian, Shen Hou, Lusha Ji, Dapeng Zhang, Huaizu Guo
The Chinese hamster ovarian (CHO) cells serve as a common choice in biopharmaceutical production, traditionally cultivated in stirred tank bioreactors (STRs). Nevertheless, the pursuit of improved protein quality and production output for commercial purposes demand exploration into new bioreactor types. In this context, inverted frustoconical shaking bioreactors (IFSB) present unique physical properties distinct from STRs. This study aims to compare the production processes of an antibody-based biotherapeutic in both bioreactor types, to enhance production flexibility...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38582926/plackett-burman-screening-of-physico-chemical-variables-affecting-citrus-peel-mediated-synthesis-of-silver-nanoparticles-and-their-antimicrobial-activity
#36
JOURNAL ARTICLE
Bardees Mickky, Heba Elsaka, Muhammad Abbas, Ahmed Gebreil, Reham Shams Eldeen
With the growing resistance of pathogenic microbes to traditional drugs, biogenic silver nanoparticles (SNPs) have recently drawn attention as potent antimicrobial agents. In the present study, SNPs synthesized with the aid of orange (Citrus sinensis) peel were engineered by screening variables affecting their properties via Plackett-Burman design. Among the variables screened (temperature, pH, shaking speed, incubation time, peel extract concentration, AgNO3 concentration and extract/AgNO3 volume ratio), pH was the only variable with significant effect on SNPs synthesis...
April 6, 2024: Scientific Reports
https://read.qxmd.com/read/38582825/optimization-of-fermentation-conditions-and-medium-components-for-chrysomycin-a-production-by-streptomyces-sp-891-b6
#37
JOURNAL ARTICLE
Zhe Hu, Qiangang Weng, Zhehui Cai, Huawei Zhang
BACKGROUND: Chrysomycin A (CA) is a promising antibiotic for treatment of Gram-positive bacterial infections and cancers. In order to enhance CA yield, optimization of fermentation conditions and medium components was carried out on strain Streptomyces sp. 891-B6, an UV-induced mutant with improved CA titer compared with its wide-type marine strain 891. RESULTS: Using one-way experiment, the optimal fermentation conditions for CA production in 1-L shake flask were obtained as follows: 12 days of fermentation time, 5 days of seed age, 5% of inoculum volume ratio, 200 mL of loading volume and 6...
April 6, 2024: BMC Microbiology
https://read.qxmd.com/read/38580800/shaking-table-tests-of-a-one-quarter-scale-model-of-concrete-hollow-block-masonry-houses-retrofitted-with-fiber-reinforced-paint
#38
JOURNAL ARTICLE
Zamzam Multazam, Kenjiro Yamamoto, Kishor Timsina, Chaitanya Krishna Gadagamma, Kimiro Meguro
Unreinforced masonry (URM) buildings are prone to significant damage when subjected to ground motion. Some strengthening methods have been proposed to increase the seismic capacity. However, the widespread adoption of these methods faces various challenges, including economic constraints experienced by common people in developing countries, the complexity of implementation, efficiency, and seismic safety of each technique. This paper introduces a new retrofitting method of fiber-reinforced paint using fiberglass as the primary reinforcing material...
April 5, 2024: Scientific Reports
https://read.qxmd.com/read/38579928/solubility-and-thermodynamics-of-mesalazine-in-aqueous-mixtures-of-poly-ethylene-glycol-200-600-at-293-2-313-2-k
#39
JOURNAL ARTICLE
Anali Ali Akbari, Aynaz Zarghampour, Nastaran Hashemzadeh, Salar Hemmati, Elaheh Rahimpour, Abolghasem Jouyban
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models...
April 3, 2024: Annales Pharmaceutiques Françaises
https://read.qxmd.com/read/38579585/persistent-pollution-of-genetic-materials-in-a-typical-laboratory-environment
#40
JOURNAL ARTICLE
Xue Li, Ce Liu, Dongbin Wang, Jianguo Deng, Yuntao Guo, Yicheng Shen, Shuwen Yang, John S Ji, Haiyun Luo, Jingwei Bai, Jingkun Jiang
From the onset of coronavirus disease (COVID-19) pandemic, there are concerns regarding the disease spread and environmental pollution of biohazard since studies on genetic engineering flourish and numerous genetic materials were used such as the nucleic acid test of the severe acute respiratory syndrome coronavirus (SARS-CoV-2). In this work, we studied genetic material pollution in an institute during a development cycle of plasmid, one of typical genetic materials, with typical laboratory settings. The pollution source, transmission routes, and pollution levels in laboratory environment were examined...
April 2, 2024: Journal of Hazardous Materials
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