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https://www.readbyqxmd.com/read/28543284/in-utero-oxcarbazepine-exposure-and-neonatal-abstinence-syndrome-case-report-and-brief-review-of-the-literature
#1
Chao-Yang Chen, Xing Li, Ling-Yue Ma, Peng-Hui Wu, Ying Zhou, Qi Feng, Yi-Min Cui
Oxcarbazepine is a second-generation antiepileptic drug that is used to treat partial seizures. Although it has been increasingly used in pregnant women, its fetal safety has not been fully validated. We describe a 12-hour-old neonate who developed neonatal abstinence syndrome (NAS) following intrauterine exposure to oxcarbazepine. The neonate was born by cesarean section to a mother who took oxcarbazepine 300 mg/day for treatment of seizures throughout her pregnancy. Approximately 12 hours after birth, the infant developed paroxysmal jitter, which mainly presented as increased excitability, irritability, limb shaking, and increased muscle tone...
May 20, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28536938/enhancement-of-5-aminolevulinic-acid-production-by-metabolic-engineering-of-the-glycine-biosynthesis-pathway-in-corynebacterium-glutamicum
#2
Yalan Zou, Tao Chen, Lili Feng, Shuanghong Zhang, Dongxu Xing, Zhiwen Wang
OBJECTIVE: To construct a strain of Corynebacterium glutamicum capable of efficiently producing 5-aminolevulinic acid (5-ALA) via the C4 pathway by modification of serine and glycine pathway using glucose as sole carbon source. RESULTS: The recombinant C. glutamicum strain AP2 harboring a codon-optimized hemA gene from Rhodobacter sphaeroides was used as host strain for 5-ALA production. A plasmid harboring the serine operon, which contained serB, serC and the site-specific mutant serA (Δ197) , was constructed and introduced into C...
May 23, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28536922/head-shaking-tilt-suppression-a-clinical-test-to-discern-central-from-peripheral-causes-of-vertigo
#3
F C Zuma E Maia, Renato Cal, Ricardo D'Albora, Sergio Carmona, Michael C Schubert
Tilt suppression refers to both tilting the head away from an Earth vertical axis and a reduction of an induced horizontal nystagmus. This phenomenon of reducing an induced horizontal nystagmus involves a circuitry of neurons within the vestibular nuclei and the cerebellum (collectively referred to as velocity storage) and signals from the otolith end organs. Lesions involving this circuitry can disrupt tilt suppression of induced horizontal nystagmus. We investigated the clinical value of combining the horizontal head-shaking nystagmus test with tilt suppression in 28 patients with unilateral peripheral vestibular hypofunction and 11 patients with lesions affecting the central nervous system...
May 23, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28530253/sensitivity-and-specificity-of-vestibular-bedside-examination-in-detecting-viii-cranial-nerve-schwannoma-with-sensorineural-sudden-unilateral-hearing-loss-as-presenting-symptom
#4
L Califano, F Salafia, M G Melillo, S Mazzone
The objectives of this study were to identify signs of vestibular nerve suffering through a bedside vestibular examination protocol in case of sudden sensorineural unilateral hearing loss without spontaneous signs of vestibular impairment and to propose a bed-side vestibular examination based protocol for the focused execution of gadolinium-enhanced magnetic resonance imaging (MRI) only if a vestibular schwannoma is suspected. 96 patients, 52 men, 44 women, mean age 57.73 +/- 12.85 years, suffering from sudden sensorineural unilateral hearing loss, which presented neither vertigo nor spontaneous nystagmus, were enrolled...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28530096/engineering-eschericha-coli-for-enhanced-tyrosol-production
#5
Yuxiang Xue, Xianzhong Chen, Cui Yang, Junzhuang Chang, Wei Shen, You Fan
Tyrosol is a phenolic compound found in olive oil and wines. The health benefits of tyrosol have attracted considerable attention. Because the tyrosol extraction from plants poses a major obstacle, biosynthesizing this compound using microbial hosts is of interest. In this study, the phenylpyruvate decarboxylase gene ARO10 and the aromatic amino acid aminotransferase gene ARO8 were introduced into Escherichia coli to generate two recombinant tyrosol producers. Deleting the prephenate dehydratase pheA and the phenylacetaldehyde dehydrogenase gene feaB improved the tyrosol production...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28527511/accumulation-of-biomass-and-four-triterpenoids-in-two-stage-cultured-poria-cocos-mycelia-and-diuretic-activity-in-rats
#6
Gao-Sheng Hu, Chong-Gui Huang, Yang Zhang, Wei Xiao, Jing-Ming Jia
Poria cocos (Schw.) Wolf, an important medicinal and food fungus, is well known in East Asia. Due to growing market demand, long cultivation period, and consumption of pine trunk during cultivation, developing alternative methods for producing P. cocos and/or its active components is of interest. In the present study, the effects of different culture methods on biomass and accumulation of four triterpenoids were investigated. The ethanol extract of fermented mycelium (EFM) was orally administered to rats. Urine output and concentrations of electrolytes (Na(+), K(+), and Cl(-)) were measured...
April 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28525203/-short-history-of-cranial-trauma-in-western-country-part-2
#7
J Noterman
The treatment of cranial traumatism has been the subject of numerous publications since the " corpus hippocraticum ". Following this period, the school of Alexandria will only be known thanks to Celsus. After him, Galen will determine the therapeutic attitude in accordance with the hippocratic theory. This theory will have an influence for more than 1.500 years. A better knowledge of anatomy will shake the galenic system for the first time at the Renaissance. The decisive progress will arise in the XIX century, with the emergence of experimental medicine, Pasteur's discoveries, and the greater knowledge of nervous system function...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28522999/fermentation-ph-modulates-the-size-distributions-and-functional-properties-of-gluconobacter-albidus-tmw-2-1191-levan
#8
Tharalinee Ua-Arak, Frank Jakob, Rudi F Vogel
Bacterial levan has gained an increasing interest over the last decades due to its unique characteristics and multiple possible applications. Levan and other exopolysaccharides (EPSs) production are usually optimized to obtain the highest concentration or yield while a possible change of the molecular size and mass during the production process is mostly neglected. In this study, the molar mass and radius of levan samples were monitored during fermentations with the food-grade, levan-producing acetic acid bacterium Gluconobacter (G...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28521794/in-vitro-synthesis-of-9-10-dihydroxyhexadecanoic-acid-using-recombinant-escherichia-coli
#9
Anees Kaprakkaden, Preeti Srivastava, Virendra Swarup Bisaria
BACKGROUND: Hydroxy fatty acids are widely used in food, chemical and cosmetic industries. A variety of dihydroxy fatty acids have been synthesized so far; however, no studies have been done on the synthesis of 9,10-dihydroxyhexadecanoic acid. In the present study recombinant E. coli has been used for the heterologous expression of fatty acid hydroxylating enzymes and the whole cell lysate of the induced culture was used for in vitro production of 9,10-dihydroxyhexadecanoic acid. RESULTS: A first of its kind proof of principle has been successfully demonstrated for the production of 9,10-dihydroxyhexadecanoic acid using three different enzymes viz...
May 18, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28513697/self-assembled-nanohelix-from-a-bolaamphiphilic-diacetylene-via-hydrogelation-and-selective-responsiveness-towards-amino-acids-and-nucleobases
#10
Yan Meng, Jian Jiang, Minghua Liu
A bolaamphiphile with diacteylene mesogen unit and l-glutamic acid as the terminal group was newly designed and its self-assembly was investigated. The compound formed hydrogels with water upon heating and cooling. The as-formed gel could be switched to a dispersion upon mechanical shaking. Both the gel and the water dispersion undergo polymerization upon UV irradiation. However, the gel turned to blue and then purple red color, while the dispersion turned red directly. Using AFM and SEM observations, it was found that nanohelix was formed in the as-prepared gel and polymerized blue gels, while nanobelt was formed from the water dispersion...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28510730/trimethoprim-sulfamethoxazole-versus-vancomycin-in-the-treatment-of-healthcare-ventilator-associated-mrsa-pneumonia-a-case-control-study
#11
Noa Eliakim-Raz, Moran Hellerman, Dafna Yahav, Jonathan Cohen, Ili Margalit, Sharon Fisher, Oren Zusman, Hila Shaked, Jihad Bishara
No abstract text is available yet for this article.
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28506930/rewiring-the-reductive-tricarboxylic-acid-pathway-and-l-malate-transport-pathway-of-aspergillus-oryzae-for-overproduction-of-l-malate
#12
Jingjing Liu, Zhipeng Xie, Hyun-Dong Shin, Jianghua Li, Guocheng Du, Jian Chen, Long Liu
Aspergillus oryzae finds wide application in the food, feed, and wine industries, and is an excellent cell factory platform for production of organic acids. In this work, we achieved the overproduction of L-malate by rewiring the reductive tricarboxylic acid (rTCA) pathway and L-malate transport pathway of A. oryzae NRRL 3488. First, overexpression of native pyruvate carboxylase and malate dehydrogenase in the rTCA pathway improved the L-malate titer from 26.1gL(-1) to 42.3gL(-1) in shake flask culture. Then, the oxaloacetate anaplerotic reaction was constructed by heterologous expression of phosphoenolpyruvate carboxykinase and phosphoenolpyruvate carboxylase from Escherichia coli, increasing the L-malate titer to 58...
May 12, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28505849/compaction-of-noncohesive-and-cohesive-granular-materials-under-vibrations-experiments-and-stochastic-model
#13
J-E Mathonnet, P Sornay, M Nicolas, B Dalloz-Dubrujeaud
We study the time evolution of the compaction of a noncohesive or cohesive granular material submitted to shaking through experiments and a stochastic model. Beyond well-known empirical expressions, we show that the characteristic time scales depend on the number of objects in the assembly. For a noncohesive granular material, the compaction time scale is governed by the number of individual grains in the system. In the case of a cohesive granular material, a two-scale model (individual particles and clusters) allows one to mimic the time evolution of the compaction of an actual cohesive powder driven by horizontal vibrations...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28501604/high-production-purification-biochemical-characterization-and-gene-analysis-of-a-novel-catalase-from-the-thermophilic-bacterium-ureibacillus-thermosphaericus-fzsf03
#14
Xianbo Jia, Xinjian Lin, Yandan Tian, Jichen Chen, Minsheng You
A catalase-producing thermophilic bacterium, Ureibacillus thermosphaericus FZSF03, was isolated from high-temperature compost. Catalase production in this strain increased 31 times and reached 57,630U/mL after optimization in a shake flask, which might represent the highest catalase activity level among reported wild strains. This catalase was further purified and identified. The purified enzyme showed a specific activity of 219,360U/mg, higher than many other catalases. The molecular weight of this enzyme is 52kDa according to sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and the enzyme was identified as a monofunctional haeme catalase of Ureibacillus thermosphaericus by liquid chromatography-mass spectrometry (LC-MS)/MS...
May 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28497554/shaking-up-the-debate-ensuring-the-ethical-use-of-dbs-intervention-criteria-for-mid-stage-parkinson-s-patients
#15
REVIEW
Marleen Eijkholt, Laura Y Cabrera, Adolfo Ramirez-Zamora, Julie G Pilitsis
OBJECTIVES: Deep brain stimulation (DBS) is a well-established treatment for the management of severe motor fluctuations in advanced Parkinson's disease (PD). Until recently, device regulation, medical, and insurance practices limited DBS to patients with advanced stages of PD. In February 2016 this changed, however, when the US Food and Drug Administration (FDA) granted formal approval for the use of brain stimulator in mid-stage PD patients. In this article, we examine whether DBS in mid-stage PD can be ethically justified beyond the FDA approval...
May 11, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28493317/attachment-and-biofilm-formation-by-selected-strains-of-salmonella-enterica-and-entrohemorrhagic-escherichia-coli-of-fresh-produce-origin
#16
Ran Han, Yaa Asantewaa Kafui Klu, Jinru Chen
This study compared the abilities of selected Salmonella enterica and enterohemorrhagic Escherichia coli (EHEC) strains of fresh produce origin to form biofilms on polystyrene surface and to attach to alfalfa and bean sprouts. Each of the 7 S. enterica and 4 EHEC inocula (2 mL; 10(7) CFU/mL) was placed in 6 different broths in 24-well polystyrene tissue culture plates at 28 °C for 1 to 7 d. Developed biofilms were quantified using the crystal violet binding assay. In a separate experiment, alfalfa and mung bean sprouts (5 g) were exposed to 25 mL inocula (10(7) CFU/mL) of S...
May 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28493122/large-scale-transient-transfection-of-chinese-hamster-ovary-cells-in-suspension
#17
Yashas Rajendra, Sowmya Balasubramanian, David L Hacker
We describe a one-liter transfection of suspension-adapted Chinese hamster ovary (CHO-DG44) cells using polyethyleneimine (PEI) for DNA delivery. The method involves transfection at a high cell density (5 × 10(6) cells/mL) by direct addition of plasmid DNA (pDNA) and PEI to the culture and subsequent incubation at 31 °C with agitation by orbital shaking. We also describe an alternative method in which 90% of the pDNA is replaced by nonspecific (filler) DNA, and the production phase is performed at 31 °C in the presence of 0...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28492782/-outbreak-of-nephritis-by-streptococcus-equi-subspecies-zooepidemicus-case-control-study-in-the-municipality-of-monte-santo-de-minas-minas-gerais-brazil-2013
#18
Patricia de Almeida Soares, Heloísa Helena Pelluci Duarte, Junara Viana de Oliveira, Leandro Leão Faúla, Rosângela Stadnick Lauth de Almeida Torres, Margareth Leonor Penkal, Mark Drew Crosland Guimarães
OBJECTIVE: to investigate an outbreak of nephritis by Streptococcus zooepidemicus in Monte Santo de Minas, Minas Gerais State, Brazil. METHODS: a case-control study and attempt to isolate the bacterial agent were carried out from January to April 2013, using clinical and laboratory data, interviews and inspections. RESULTS: 417 suspected cases were reported, of which 175 (42.0%) were confirmed; 90.9% lived in that municipality, of which 67...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28487199/production-of-chitinase-from-thermophilic-humicola-grisea-and-its-application-in-production-of-bioactive-chitooligosaccharides
#19
Manish Kumar, Amandeep Brar, V Vivekanand, Nidhi Pareek
A novel thermophilic chitinase producing strain Humicola grisea ITCC 10,360.16 was isolated from soil of semi-arid desert region of Rajasthan. Maximum enzyme production (116±3.45Ul(-1)) was achieved in submerged fermentation. Nutritional requirement for maximum production of chitinase under submerged condition was optimized using response surface methodology. Among the eight nutritional elements studied, chitin, colloidal chitin, KCl and yeast-extract were identified as the most critical variables for chitinase production by Plackett-Burman design first...
May 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28482941/disrupted-identities-movement-mind-and-memory-in-parkinson-s-disease
#20
Iracema Leroi
For the many clinicians au fait with the history of the clinical description of Parkinson's disease, they will be aware that the very earliest description of James Parkinson's "Shaking Palsy" in 1817 explicitly excluded the involvement of cognitive and emotional processes as manifestations of the disease. Within a short time following his treatise, it became all too clear to those in the field that Parkinson's disease is more than just a motor disorder, and as was aptly conceptualized by Paul McHugh, Professor of Psychiatry at Johns Hopkins Hospital from 1975 until 2001, Parkinson's disease is closer to being a "triadic disorder," encompassing motor, cognitive, and psychiatric elements (McHugh, 1989)...
June 2017: International Psychogeriatrics
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