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https://www.readbyqxmd.com/read/28531270/utilization-of-quantitative-susceptibility-mapping-for-direct-targeting-of-the-subthalamic-nucleus-during-deep-brain-stimulation-surgery
#1
Jonathan Rasouli, Ritesh Ramdhani, Fedor E Panov, Alexey Dimov, Yan Zhang, Catherine Cho, Yi Wang, Brian Harris Kopell
BACKGROUND: Deep brain stimulation of the subthalamic nucleus (STN) has demonstrated efficacy in improving motor disability in Parkinson's disease. The recently developed quantitative susceptibility mapping (QSM) technique, which can accurately map iron deposits in deep brain nuclei, promises precise targeting of the STN. OBJECTIVE: To demonstrate the use of QSM to target STN effectively by correlating with classical physiological-based targeting measures in a prospective study...
May 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28531192/overexpression-of-the-essential-sis1-chaperone-reduces-tdp-43-effects-on-toxicity-and-proteolysis
#2
Sei-Kyoung Park, Joo Y Hong, Fatih Arslan, Vydehi Kanneganti, Basant Patel, Alex Tietsort, Elizabeth M H Tank, Xingli Li, Sami J Barmada, Susan W Liebman
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dependent toxicity, we now show that TDP-43 overexpression dramatically alters cell shape and reduces ubiquitin dependent proteolysis of a reporter construct. Furthermore, we show that an excess of the Hsp40 chaperone, Sis1, reduced TDP-43's effect on toxicity, cell shape and proteolysis...
May 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28531191/exogenous-expression-of-drp1-plays-neuroprotective-roles-in-the-alzheimer-s-disease-in-the-a%C3%AE-42-transgenic-drosophila-model
#3
Fengshou Lv, Xiaopeng Yang, Chuanju Cui, Chunhe Su
BACKGROUND: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders. Recent studies have shown that mitochondrial dysfunction is a causative factor of AD. Drp1 (Dynamin-related protein 1), a regulator of mitochondrial fission, shows neuroprotective effects on Parkinson's disease. In this study, we investigate the effect and mechanism of Drp1 on Aβ42 transgenic Drosophila. METHODS: Elav-gal4/UAS>Aβ42 transgenic Drosophila model was constructed using Elav-gal4 promoter...
2017: PloS One
https://www.readbyqxmd.com/read/28530766/right-ring-finger-volar-mass-in-a-14-year-old-boy
#4
Mary P Fox, Jack E McKay, Randall D Craver, Nicholas D Pappas
A trigger digit is relatively uncommon in adolescents and often has a different etiology in that age group vs adults. In the pediatric population, trigger digits frequently arise from a variety of underlying anatomic situations, including thickening of the flexor digitorum superficialis or flexor digitorum profundus tendons, an abnormal relationship between the flexor digitorum superficialis and flexor digitorum profundus tendons, a proximal flexor digitorum superficialis decussation, or constriction of the pulleys...
May 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28530758/self-thermophoretic-motion-of-controlled-assembled-micro-nanomotors
#5
Xiankun Lin, Tieyan Si, Zhiguang Wu, Qiang He
As artificial active colloids, micro-/nanomotors (MNMs) can convert energy from the environment into mechanical motion in different fluids, showing potential applications in diverse fields such as targeted drug delivery and photothermal therapy. However, chemical fuels for typical catalytic MNMs, e.g., hydrogen peroxide, are highly toxic to organisms, and thus fuel-free MNMs are required. Recently, we have developed near-infrared light (NIR) propelled MNMs through integrating plasmonic gold nanoshells into nanoparticles or layer-by-layer assemblies in an asymmetric manner...
May 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28530663/a-cerebellum-like-circuit-in-the-auditory-system-cancels-responses-to-self-generated-sounds
#6
Shobhit Singla, Conor Dempsey, Richard Warren, Armen G Enikolopov, Nathaniel B Sawtell
The dorsal cochlear nucleus (DCN) integrates auditory nerve input with a diverse array of sensory and motor signals processed in circuitry similar to that of the cerebellum. Yet how the DCN contributes to early auditory processing has been a longstanding puzzle. Using electrophysiological recordings in mice during licking behavior, we show that DCN neurons are largely unaffected by self-generated sounds while remaining sensitive to external acoustic stimuli. Recordings in deafened mice, together with neural activity manipulations, indicate that self-generated sounds are cancelled by non-auditory signals conveyed by mossy fibers...
May 22, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28530659/actin-cortex-architecture-regulates-cell-surface-tension
#7
Priyamvada Chugh, Andrew G Clark, Matthew B Smith, Davide A D Cassani, Kai Dierkes, Anan Ragab, Philippe P Roux, Guillaume Charras, Guillaume Salbreux, Ewa K Paluch
Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previous cortical tension regulation studies have focused on myosin motors. Here, we show that cortical actin network architecture is equally important. First, we observe that actin cortex thickness and tension are inversely correlated during cell-cycle progression. We then show that the actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and find that both increasing and decreasing thickness decreases tension in mitosis...
May 22, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28530504/functional-recovery-after-rotator-cuff-repair-the-role-of-biceps-surgery
#8
Bernardo Gialanella, Francesco Grossetti, Marina Mazza, Laura Danna, Laura Comini
CONTEXT: Surgical cuff repair is indicated in full-thickness rotator cuff tear when non-operative treatment fails. Surgical cuff repair can comprehend surgery of long head of the biceps when concomitant biceps pathology is present. However, the studies executed up to now do not have yet clearly defined if additional biceps surgery affects the shoulder functionality in patients who underwent rotator cuff repair. OBJECTIVE: The aim of this study is to verify if the concomitant biceps surgery prejudices the shoulder functionality during the short-term period in rotator cuff repair patients...
May 22, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28530500/sex-specific-links-in-motor-and-sensory-adaptations-to-repetitive-motion-induced-fatigue
#9
Zachary R Weber, Divya Srinivasan, Julie N Côté
The objectives of this study were to assess the sex-specific relationships between motor and sensory adaptations to repetitive arm motion-induced neck/shoulder fatigue, and measure how additional sensory stimulation affected these adaptations. Twenty-three participants performed two sessions of a repetitive pointing task until scoring 8 on the Borg CR10 scale for neck/shoulder exertion or for a maximum of 45min, with and without sensory stimulation (i.e. light touch) applied on the fatiguing shoulder. Just before reaching the task termination criteria, all participants showed changes in mean and variability of arm joint angles and experienced a five-fold increase in anterior deltoid (AD) sensory threshold in the stimulus-present condition...
May 22, 2017: Motor Control
https://www.readbyqxmd.com/read/28530460/unravelling-motor-learning-processes-in-theatre-performers
#10
Emmanuel Jacobs, Ann Hallemans, Jan Gielen, Luc Van den Dries, Annouk Van Moorsel, Jonas Rutgeerts, Nathalie Roussel
Theatre performers, more than common actors, experience high physical loadings. This study aimed at analysing the motor behaviour ofnovice performers (dancers/actors who were introduced to the acting method of Jan Fabre), by investigating the kinematics of a physical acting exercises in a prospective study. Two measurement sessions were organised, before and after the novice performers (n = 13) took part in seven workshops. Total body kinematics were registered using a 3D motion capture system. By using a Principal Component Analysis (PCA), six factors were disseminated out of 30 kinematic parameters: Pelvic Motion, Speed of Progression, Lower Limb Position, Foot Motion, Lower Limb Motion and Trunk Position...
May 22, 2017: Motor Control
https://www.readbyqxmd.com/read/28530245/shifting-the-optimal-stiffness-for-cell-migration
#11
Benjamin L Bangasser, Ghaidan A Shamsan, Clarence E Chan, Kwaku N Opoku, Erkan Tüzel, Benjamin W Schlichtmann, Jesse A Kasim, Benjamin J Fuller, Brannon R McCullough, Steven S Rosenfeld, David J Odde
Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal. Here we present a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the number of active molecular motors and clutches. This prediction is verified experimentally by comparing cell traction and F-actin retrograde flow for two cell types with differing amounts of active motors and clutches: embryonic chick forebrain neurons (ECFNs; optimum ∼1 kPa) and U251 glioma cells (optimum ∼100 kPa)...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28530229/deep-sleep-maintains-learning-efficiency-of-the-human-brain
#12
Sara Fattinger, Toon T de Beukelaar, Kathy L Ruddy, Carina Volk, Natalie C Heyse, Joshua A Herbst, Richard H R Hahnloser, Nicole Wenderoth, Reto Huber
It is hypothesized that deep sleep is essential for restoring the brain's capacity to learn efficiently, especially in regions heavily activated during the day. However, causal evidence in humans has been lacking due to the inability to sleep deprive one target area while keeping the natural sleep pattern intact. Here we introduce a novel approach to focally perturb deep sleep in motor cortex, and investigate the consequences on behavioural and neurophysiological markers of neuroplasticity arising from dedicated motor practice...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28530225/a-canonical-neural-mechanism-for-behavioral-variability
#13
Ran Darshan, William E Wood, Susan Peters, Arthur Leblois, David Hansel
The ability to generate variable movements is essential for learning and adjusting complex behaviours. This variability has been linked to the temporal irregularity of neuronal activity in the central nervous system. However, how neuronal irregularity actually translates into behavioural variability is unclear. Here we combine modelling, electrophysiological and behavioural studies to address this issue. We demonstrate that a model circuit comprising topographically organized and strongly recurrent neural networks can autonomously generate irregular motor behaviours...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28530154/determining-electrode-placement-for-transcranial-direct-current-stimulation-a-comparison-of-eeg-versus-tms-guided-methods
#14
Tonya L Rich, Jeremiah S Menk, Kyle D Rudser, Mo Chen, Gregg D Meekins, Edgar Peña, Timothy Feyma, Kay Bawroski, Christina Bush, Bernadette T Gillick
Transcranial direct current stimulation (tDCS) is increasingly researched as an adjuvant to motor rehabilitation for children with hemiparesis. The optimal method for the primary motor cortex (M1) somatotopic localization for tDCS electrode placement has not been established. The objective, therefore, was to determine the location of the M1 derived using the 10/20 electroencephalography (EEG) system and transcranial magnetic stimulation (TMS) in children with hemiparesis (CWH) and a comparison group of typically developing children (TDC)...
May 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28530089/use-of-low-frequency-repetitive-transcranial-magnetic-stimulation-to-reduce-context-dependent-learning-in-people-with-parkinson-s-disease
#15
Ya-Yun Lee, Beth E Fisher
BACKGROUND: Compared with age-matched non-disabled adults, people with Parkinson's disease (PD) demonstrated greater context-dependent learning, a phenomenon in which an individual shows inferior motor performance when the testing environmental context is different from the original practice context. Additionally, enhanced context- dependency has been shown to be associated with an increased activation of the dorsolateral prefrontal cortex (DLPFC). AIM: This study aimed to determine whether context-dependent learning in people with PD could be reduced by decreasing DLPFC activation with low frequency repetitive transcranial magnetic stimulation (rTMS)...
May 22, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28529891/biomonitorization-of-iron-accumulation-in-the-substantia-nigra-from-lewy-body-disease-patients
#16
Belén Fernández, Isidro Ferrer, Fernando Gil, Sabine Hilfiker
Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinson's disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28529878/neuroimaging-in-pre-motor-parkinson-s-disease
#17
REVIEW
Thomas R Barber, Johannes C Klein, Clare E Mackay, Michele T M Hu
The process of neurodegeneration in Parkinson's disease begins long before the onset of clinical motor symptoms, resulting in substantial cell loss by the time a diagnosis can be made. The period between the onset of neurodegeneration and the development of motoric disease would be the ideal time to intervene with disease modifying therapies. This pre-motor phase can last many years, but the lack of a specific clinical phenotype means that objective biomarkers are needed to reliably detect prodromal disease...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28529870/symptom-specific-amygdala-hyperactivity-modulates-motor-control-network-in-conversion-disorder
#18
Thomas Hassa, Alexandra Sebastian, Joachim Liepert, Cornelius Weiller, Roger Schmidt, Oliver Tüscher
Initial historical accounts as well as recent data suggest that emotion processing is dysfunctional in conversion disorder patients and that this alteration may be the pathomechanistic neurocognitive basis for symptoms in conversion disorder. However, to date evidence of direct interaction of altered negative emotion processing with motor control networks in conversion disorder is still lacking. To specifically study the neural correlates of emotion processing interacting with motor networks we used a task combining emotional and sensorimotor stimuli both separately as well as simultaneously during functional magnetic resonance imaging in a well characterized group of 13 conversion disorder patients with functional hemiparesis and 19 demographically matched healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28529806/increased-alpha-rhythm-dynamic-range-promotes-recovery-from-visuospatial-neglect-a-neurofeedback-study
#19
Tomas Ros, Abele Michela, Anne Bellman, Philippe Vuadens, Arnaud Saj, Patrik Vuilleumier
Despite recent attempts to use electroencephalogram (EEG) neurofeedback (NFB) as a tool for rehabilitation of motor stroke, its potential for improving neurological impairments of attention-such as visuospatial neglect-remains underexplored. It is also unclear to what extent changes in cortical oscillations contribute to the pathophysiology of neglect, or its recovery. Utilizing EEG-NFB, we sought to causally manipulate alpha oscillations in 5 right-hemisphere stroke patients in order to explore their role in visuospatial neglect...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28529762/enhanced-inter-subject-brain-computer-interface-with-associative-sensorimotor-oscillations
#20
Simanto Saha, Khawza I Ahmed, Raqibul Mostafa, Ahsan H Khandoker, Leontios Hadjileontiadis
Electroencephalography (EEG) captures electrophysiological signatures of cortical events from the scalp with high-dimensional electrode montages. Usually, excessive sources produce outliers and potentially affect the actual event related sources. Besides, EEG manifests inherent inter-subject variability of the brain dynamics, at the resting state and/or under the performance of task(s), caused probably due to the instantaneous fluctuation of psychophysiological states. A wavelet coherence (WC) analysis for optimally selecting associative inter-subject channels is proposed here and is being used to boost performances of motor imagery (MI)-based inter-subject brain computer interface (BCI)...
February 2017: Healthcare Technology Letters
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