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https://www.readbyqxmd.com/read/28651400/-mobile-internet-based-survey-of-current-status-of-hiv-test-and-related-factors-in-men-who-have-sex-with-men-in-college-students-in-china
#1
Y Y Jin, J Xu, Z Jiang, Z Y Wu
Objective: To assess the current status of HIV test during the past year and related factors in men who have sex with men (MSM) in college students in China. Methods: Based on a MSM website, a cross-sectional study was conducted in 500 MSM in college students aged 18-25 years, who were selected based on the estimated HIV detection rate of 50% in this population, by means of mobile phone questionnaire survey. χ(2) test and non-conditional multivariate logistic regression analysis were conducted to identify the factors related with HIV test, respectively...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651375/chromatographic-and-computational-assessment-of-lipophilicity-of-new-anticancer-acetylenequinoline-derivatives
#2
Krzysztof Marciniec, Stanislaw Boryczka
The lipophilicity of a series of anticancer propargylquinoline derivatives is investigated using both chromatographic and computational methods. The parameters of the tested compounds' relative lipophilicity (logkw) are determined experimentally by the high-performance liquid chromatographic method (RP-HPLC, Accucore C18 column), using mixtures of acetonitrile and water as mobile phases. Mobile phase acetonitrile concentrations range between 50 and 80%. The logk values of the investigated compounds are linearly dependent upon the acetonitrile concentration...
June 23, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28651314/stabilization-of-heavy-metals-in-soil-using-two-organo-bentonites
#3
Kai Yu, Jian Xu, Xiaohong Jiang, Cun Liu, Wesley McCall, Jinlong Lu
Stabilization of Cu, Zn, Cd, Hg, Cr and As in soil using tetramethylammonium (TMA) and dodecyltrimethylammonium (DTMA) modified bentonites (T-Bents and D-Bents) as amendments was investigated. Toxicity characteristic leaching procedure (TCLP) was used to quantify the metal mobility after soil treatment. The structural parameters of modified bentonites, including the BET surface area, basal spacing and zeta potential were obtained as a function of the TMA and DTMA loading at 40, 80, 120, 160 and 200% of the bentonite's cation exchange capacity, respectively...
June 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28651225/developing-pyridazine-3-carboxamides-to-be-cb2-agonists-the-design-synthesis-structure-activity-relationships-and-docking-studies
#4
Hai-Yan Qian, Zhi-Long Wang, Xiao-Yu Xie, You-Lu Pan, Gang-Jian Li, Xin Xie, Jian-Zhong Chen
Herein, we described the design and synthesis of a series of pyridazine-3-carboxamides to be CB2-selective agonists via a combination of scaffold hopping and bioisosterism strategies. The compounds were subjected to assessment of their potential activities through calcium mobilization assays. Among the tested derivatives, more than half of these compounds exhibited moderate to potent CB2 agonist activity. Six compounds showed EC50 values below 35 nM, and several derivatives also exhibited significantly enhanced potency and high selectivity at the CB2 receptor over the CB1 receptor...
May 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28651221/risk-element-immobilization-stabilization-potential-of-fungal-transformed-dry-olive-residue-and-arbuscular-mycorrhizal-fungi-application-in-contaminated-soils
#5
Mercedes García-Sánchez, Tereza Stejskalová, Inmaculada García-Romera, Jiřina Száková, Pavel Tlustoš
The use of biotransformed dry olive residue (DOR) as organic soil amendment has recently been proposed due to its high contents of stabilized organic matter and nutrients. The potential of biotransformed DOR to immobilize risk elements in contaminated soils might qualify DOR as a potential risk element stabilization agent for in situ soil reclamation practices. In this experiment, the mobility of risk elements in response to Penicillium chrysogenum-10-transformed DOR, Funalia floccosa-transformed DOR, Bjerkandera adusta-transformed DOR, and Chondrostereum purpureum-transformed DOR as well as arbuscular mycorrhizal fungi (AMF), Funneliformis mosseae, inoculation was investigated...
June 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28651173/development-validation-and-clinical-application-of-a-method-for-the-simultaneous-quantification-of-lamivudine-emtricitabine-and-tenofovir-in-dried-blood-and-dried-breast-milk-spots-using-lc-ms-ms
#6
Catriona Waitt, Sujan Diliiy Penchala, Adeniyi Olagunju, Alieu Amara, Laura Else, Mohammed Lamorde, Saye Khoo
OBJECTIVES: To present the validation and clinical application of a LC-MS/MS method for the quantification of lamivudine (3TC), emtricitabine (FTC) and tenofovir (TFV) in dried blood spots (DBS) and dried breast milk spots (DBMS). METHODS: DBS and DBMS were prepared from 50 and 30μL of drug-spiked whole blood and human breast milk, respectively. Following extraction with acetonitrile and water, chromatographic separation utilised a Synergi polar column with a gradient mobile phase program consisting of 0...
June 17, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28651109/separation-of-furostanol-saponins-by-supercritical-fluid-chromatography
#7
Jie Yang, Lingling Zhu, Yang Zhao, Yongwei Xu, Qinglong Sun, Shuchen Liu, Chao Liu, Baiping Ma
Supercritical fluid chromatography (SFC) has good separation efficiency and is suitable for separating weakly polar compounds. Furostanol saponins, as an important kind of steroidal saponins, generally have two sugar chains, which are polar and hydrophilic. The hydroxyl group at the C-22 position of furostanol saponins is active and easily reacts with lower alcohols under appropriate conditions. The separation of hydrophilic furostanol saponins was tested by SFC in this study. The effects of chromatographic conditions on the separation of the mixed furostanol saponins and their hydroxyl derivatives at the C-22 position were studied...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28651031/assessment-of-fall-characteristics-from-depth-sensor-videos
#8
Jennifer J O'Connor, Lorraine J Phillips, Bunmi Folarinde, Gregory L Alexander, Marilyn Rantz
Falls are a major source of death and disability in older adults; little data, however, are available about the etiology of falls in community-dwelling older adults. Sensor systems installed in independent and assisted living residences of 105 older adults participating in an ongoing technology study were programmed to record live videos of probable fall events. Sixty-four fall video segments from 19 individuals were viewed and rated using the Falls Video Assessment Questionnaire. Raters identified that 56% (n = 36) of falls were due to an incorrect shift of body weight and 27% (n = 17) from losing support of an external object, such as an unlocked wheelchair or rolling walker...
July 1, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28651019/in-silico-genomic-insights-into-aspects-of-food-safety-and-defense-mechanisms-of-a-potentially-probiotic-lactobacillus-pentosus-mp-10-isolated-from-brines-of-naturally-fermented-alore%C3%A3-a-green-table-olives
#9
Hikmate Abriouel, Beatriz Pérez Montoro, María Del Carmen Casado Muñoz, Charles W Knapp, Antonio Gálvez, Nabil Benomar
Lactobacillus pentosus MP-10, isolated from brines of naturally fermented Aloreña green table olives, exhibited high probiotic potential. The genome sequence of L. pentosus MP-10 is currently considered the largest genome among lactobacilli, highlighting the microorganism's ecological flexibility and adaptability. Here, we analyzed the complete genome sequence for the presence of acquired antibiotic resistance and virulence determinants to understand their defense mechanisms and explore its putative safety in food...
2017: PloS One
https://www.readbyqxmd.com/read/28650942/open-supracondylar-intercondylar-fractures-of-the-femur-treatment-with-taylor-spatial-frame
#10
Francesco Sala, Ahmed M Thabet, Paolo Capitani, Federico Bove, Amr A Abdelgawad, Giovanni Lovisetti
OBJECTIVES: Evaluate the Taylor spatial frame (TSF) for primary and definitive fixation of open supracondylar-intracondylar femoral (SIF) fractures. DESIGN: Retrospective. SETTING: Level I trauma center. PATIENTS: Subset of 20 SIF open fractures treated with TSF extracted from a consecutive series of 80 SIF fractures treated between 2007 and 2013. INTERVENTION: Eighteen (90%) fractures underwent definitive fixation with the TSF; 2 were treated primarily within 24 hours of injury...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650906/academic-progression-in-nursing-education-advancing-seamless-educational-mobility
#11
Teresa W Yambo
No abstract text is available yet for this article.
June 23, 2017: Nurse Educator
https://www.readbyqxmd.com/read/28650848/ser-thr-protein-kinase-b2-nadph-oxidase-2-signaling-in-thromboinflammation
#12
Jing Li, Jaehyung Cho
PURPOSE OF REVIEW: Interactions between neutrophils and platelets contribute to the progression of thromboinflammatory disease. However, the regulatory mechanism governing these interactions is poorly understood. The present review focuses on the crucial role of Ser/Thr protein kinase B (AKT)2-NADPH oxidase 2 (NOX2) signaling in regulating neutrophil and platelet activation and their heterotypic interactions under thromboinflammatory conditions. RECENT FINDINGS: Growing evidence has shown that platelets, leukocytes, and blood coagulation need to be considered to treat thromboinflammatory disease in which inflammation and thrombosis occur concurrently...
June 24, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28650762/angioleiomyoma-of-the-lower-leg
#13
Robert L B Sprinkle, Omar P Sangueza, Ashleigh E Wells
Angioleiomyomas are benign tumefactions that originate from smooth muscle in vascular structures and are difficult to definitively diagnose preoperatively. Although these lesions are rarely encountered in the foot, the lower extremity is the most common site of occurrence. An angioleiomyoma typically manifests as a small, painful, solitary, mobile lesion. This case report describes a lateral retromalleolar para-Achilles tendon insertional location for a moderately sized immobile solid tumefaction in the subcutaneous tissues...
May 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28650601/multiple-sclerosis-in-an-acupuncture-practice
#14
(no author information available yet)
Multiple sclerosis (MS) is a severe autoimmune demyelinating disease that affects nervous system, has high morbidity and mortality and no effective targeted therapies are available. We present a case of 66-year-old female patient who has been treated by both conventional and Chinese traditional medicine after diagnosis was confirmed in 2008 as MS and antiphospholipid syndrome associated with CNS vasculitis. After diagnosis with clinical image confirmed with CT and MRI scan, where demyelinating zones were present, she started pharmacological therapy without major improvement...
May 26, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28650454/analysis-of-hematopoietic-recovery-after-autologous-transplantation-as-method-of-quality-control-for-long-term-progenitor-cell-cryopreservation
#15
J Pavlů, H W Auner, R M Szydlo, B Sevillano, R Palani, F O'Boyle, A Chaidos, C Jakob, E Kanfer, D MacDonald, D Milojkovic, A Rahemtulla, A Bradshaw, E Olavarria, J F Apperley, O M Pello
Hematopoietic precursor cells (HPC) are able to restore hematopoiesis after high-dose chemotherapy and their cryopreservation is routinely employed prior to the autologous hematopoietic cell transplantation (AHCT). Although previous studies showed feasibility of long-term HPC storage, concerns remain about possible negative effects on their potency. To study the effects of long-term cryopreservation, we compared time to neutrophil and platelet recovery in 50 patients receiving two AHCT for multiple myeloma at least 2 years apart between 2006 and 2016, using HPC obtained from one mobilization and collection attempt before the first transplant...
June 26, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28650336/design-and-content-determination-of-genhuang-dispersible-tablet-herbal-formulation
#16
Rui-Hua Xin, Ge Liang, Ji-Fang Zheng
The aim of the present study was to optimize the shaping technology of the traditional herbal formula Genhuang dispersible tablets, and also establish a method for content determination. The optimal formulation of Genhuang dispersible tablets was determined based on the results of single factor test and orthogonal design test. The disintegration was used as the main study indicator. The proportion of each adjuvant in the optimal formulation consisted of 40% MCC as bulking agent, 15% PVPP and 7% L-HPC as disintegrant, ethanol as adhesive, CSD as lubricant, preparing the dispersible tablets with wet granulation...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28650333/simultaneous-determination-of-ace-inhibitors-and-dexibuprofen-in-active-pharmaceutical-ingredient-formulations-and-human-serum-by-rp-hplc
#17
Aisha Sana, Safila Naveed, Fatima Qamar, Sadia Shakeel
The contemporary work describes a rapid and cost effective reversed phase High Performance Liquid Chromatography (RP-HPLC) method for the quantification of Captopril, Lisinopril and Dexibuprofen (DXP) simultaneously in dosage formulations, active pharmaceutical ingredients and human serum. The chromatographic system included LC-20A pump, Sil-20A auto sampler and SPD-20A UV/visible detector. The estimation was carried out by using a C18 (5μm, 250 ×4.6 mm) column with mobile phase methanol: water (80:20 v/v, pH 3...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28650313/molecular-mechanisms-and-epidemiology-of-resistance-in-streptococcus-pneumoniae-in-the-middle-east-region
#18
Grace El Moujaber, Marwan Osman, Rayane Rafei, Fouad Dabboussi, Monzer Hamze
PURPOSE: Streptococcus pneumoniae is a commensal bacterium that normally colonizes the human nasopharyngeal cavity. Once disseminated, it can cause several diseases, ranging from non-invasive infections such as acute otitis media and sinusitis through to invasive infections with higher mortality, including meningitis and septicaemia. Since the identification of the first S. pneumoniae strain with decreased susceptibility to penicillin in the 1960s, antibiotic resistance among S. pneumoniae has increased disturbingly and the mechanisms of resistance have begun to unfold...
June 26, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28650177/learning-on-hold-cell-phones-sidetrack-parent-child-interactions
#19
Jessa Reed, Kathy Hirsh-Pasek, Roberta Michnick Golinkoff
Although research suggests that responsive interactions are imperative for language development, the advent of mobile technology means that parent-child exchanges are often fraught with unpredictable interruptions. Less clear is how these momentary breaks in responsiveness affect word learning. In this within-subjects design, 38 mothers taught their 2-year-olds (M = 27.15 months) 2 novel words, 1 at a time. One teaching period was interrupted by a cell phone call. Children learned the word when the teaching was not interrupted, but not when it was interrupted...
June 26, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28650148/mgzno-zno-two-dimensional-electron-gas-photodetectors-fabricated-by-rf-sputtering
#20
J D Hwang, C C Yang, C M Chu
MgZnO/ZnO two-dimensional electron gas (2DEG) structures with ZnO annealed at various temperatures (600-900 ºC) and photodetectors (PDs) with and without a 2DEG structure were fabricated using a radio-frequency magnetron sputtering system. It was found that the carrier concentration and mobility increase with the annealing temperature owing to the improved crystalline in ZnO; however, high-temperature (800 ºC or higher) annealing can degrade the crystalline of the ZnO layer. Hall measurements showed that compared with bulk ZnO, the sheet carrier concentration of the 2DEG sample increased from 1...
June 26, 2017: ACS Applied Materials & Interfaces
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