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https://www.readbyqxmd.com/read/29678977/minimizing-icu-neurological-dysfunction-with-dexmedetomidine-induced-sleep-mindds-protocol-for-a-randomised-double-blind-parallel-arm-placebo-controlled-trial
#1
Kenneth T Shelton, Jason Qu, Federico Bilotta, Emery N Brown, Gaston Cudemus, David A D'Alessandro, Hao Deng, Alan DiBiasio, Jacob A Gitlin, Eunice Y Hahm, Lauren E Hobbs, Timothy T Houle, Reine Ibala, Marco Loggia, Kara J Pavone, Shahzad Shaefi, George Tolis, M Brandon Westover, Oluwaseun Akeju
INTRODUCTION: Delirium, which is prevalent in postcardiac surgical patients, is an acute brain dysfunction characterised by disturbances in attention, awareness and cognition not explained by a pre-existing neurocognitive disorder. The pathophysiology of delirium remains poorly understood. However, basic science and clinical studies suggest that sleep disturbance may be a modifiable risk factor for the development of delirium. Dexmedetomidine is a α-2A adrenergic receptor agonist medication that patterns the activity of various arousal nuclei similar to sleep...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678196/astroblastoma-a-rare-and-challenging-tumor-a-case-report-and-review-of-the-literature
#2
Nawal Hammas, Nadia Senhaji, My Youssef Alaoui Lamrani, Sanae Bennis, Elfaiz Mohamed Chaoui, Hind El Fatemi, Laila Chbani
BACKGROUND: Astroblastoma is a controversial and an extremely rare central nervous system neoplasm. Although its histogenesis has been clarified recently, controversies exist regarding its cellular origin and validity as a distinct entity. Because of its extreme rarity and because its common features are shared with other glial neoplasms, this tumor is prone to misdiagnosis and remains challenging not only in terms of diagnosis and classification but also in the subsequent management...
April 21, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29677962/the-re-relaunching-of-the-dmp-the-french-shared-medical-record-new-features-to-improve-uptake-and-use
#3
Brigitte Séroussi, Jacques Bouaud
Health care delivery for patients with chronic conditions is complex and confusing. Care is often fragmented, less effective, and sometimes harmful. Given the potential for EHRs and other health IT systems to facilitate information flow between providers, patients, and settings, health IT-based measures are of particular interest for care coordination. Health information exchange (HIE) has the potential to improve the quality of healthcare by enabling providers with better access to patient information from multiple sources at the point of care...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677960/electronic-health-records-from-the-management-of-patients-to-the-research-use-of-clinical-data
#4
Barbara Giannini, Francesco Curtaz, Filippo Del Puente, Antonio Di Biagio, Mauro Giacomini
Paper based medical records are still widespread in Italian hospitals and the workflow to manage outpatients' visits is critical. Too many isolated software programs coexist in hospital wards and cause confusion and disorganization. A computerized medical record that unifies all the data contained in the various applications should be of fundamental importance in supporting physician's daily activities. Moreover, with the digital clinical record, data can be re-used for research purposes. The aim of this project is to create a web application for the management of outpatient visits to the Infectious Diseases Unit of the San Martino Hospital in Genoa...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677066/agreement-analysis-what-he-said-she-said-versus-you-said
#5
Thomas R Vetter, Patrick Schober
Correlation and agreement are 2 concepts that are widely applied in the medical literature and clinical practice to assess for the presence and strength of an association. However, because correlation and agreement are conceptually distinct, they require the use of different statistics. Agreement is a concept that is closely related to but fundamentally different from and often confused with correlation. The idea of agreement refers to the notion of reproducibility of clinical evaluations or biomedical measurements...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29676863/nitrite-stress-disrupts-the-structural-integrity-and-induces-oxidative-stress-response-in-the-intestines-of-pacific-white-shrimp-litopenaeus-vannamei
#6
Yafei Duan, Jiasong Zhang, Yun Wang, Qingsong Liu, Dalin Xiong
The acute toxicity of nitrite on the mucosal morphology and oxidative stress response was investigated in the intestines of Litopenaeus vannamei after the exposure of 20 mg/L nitrite for 72 hr. The duration of nitrite stress influenced the shrimp survival, and the cumulative mortality rate was 36.7% at 72 hr. Hematoxylin and eosin (HE) stain showed that nitrite stress damaged the intestine connective and epithelium tissue. Specifically, nitrite stress increased the content of reactive oxygen species (ROS) production (O2 - generation capacity), lipid peroxidation (LPO), and malondialdehyde (MDA)...
April 20, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29676708/-urticaria-multiforme-difficult-to-distinguish-from-other-skin-conditions
#7
L Zijp, P M J H Kemperman, G W den Tusscher
BACKGROUND: Urticaria multiforme is a rare clinical variant of urticaria that occurs specifically in children. CASE DESCRIPTION: A boy aged 11 months was presented at the Emergency Department with acute onset of itching urticarial skin weals and acral oedema. This picture is consistent with the diagnosis of urticaria multiforme. CONCLUSION: The diagnosis of urticaria multiforme can be made on the basis of the clinical picture. Treatment is symptomatic and in most cases this condition resolves spontaneously within two weeks...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676362/expression-of-e-cadherin-syndecan-1-ki-67-and-maintenance-minichromosome-3-in-tissue-lesions-of-actinic-prurigo-obtained-by-incisional-biopsy
#8
Alexandra Mancheno-Valencia, Ronell Eduardo Bologna-Molina, Sonia Toussaint-Caire, María Elisa Vega-Memije, Juan Carlos Cuevas-González
Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained lymphoid follicles (Ki 67: epidermis [17...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675842/oxygen-to-little-too-much-or-just-right
#9
EDITORIAL
Pontus B Persson, Anja B Persson
Supply and demand, delivery obstacles and a number of complex systems to classify shortages - in physiology texts, oxygen appears to be one of the most in depth- researched commodity on the market. Classifications of the different states of "too little oxygen in relation to demand" usually start of textbook chapters and never cease to cause a lot of confusion among learners. The immediate and long-term effects of varying oxygen tensions, their consequences and pathophysiological relevance are what most of the journal articles that come up in databases when you enter hypoxia as a search term are centred on...
April 19, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29675757/fetal-methotrexate-syndrome-and-antley-bixler-syndrome-should-not-be-confused
#10
REVIEW
C Richards, Christine M Hall, D Johnson, Amaka C Offiah
Exposure to methotrexate in utero can result in fetal methotrexate syndrome - a condition characterised by prenatal-onset growth retardation, craniosynostosis, dysmorphic facies and multiple limb abnormalities. A literature review was prompted by the findings in a girl who is presented here with full consent from her guardian. She is the third child of unrelated parents and was 4 years old at the time of this report. Her mother took 15 mg methotrexate on two occasions during early pregnancy for juvenile idiopathic arthritis, unaware that she was pregnant...
April 19, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29675477/dextranomer-hyaluronic-acid-calcification-masquerading-as-distal-ureteral-calculi-in-a-patient-previously-treated-for-vesicoureteral-reflux
#11
Muammer Bozkurt, Samir Agalarov, Erkan Merder, Fatih Altunrende
Subureteral endoscopic injection is a safe and effective treatment for vesicoureteral reflux (VUR). Dextranomer/hyaluronic acid (Dx/HA) is the most commonly used bulking agent for the treatment of VUR. We report a confusing radiographic finding of calcified Dx/HA injection initially simulates distal ureteral stone in a female patient who has intermittent lumbar pain. Calcification of Dx/HA implants may mimic distal ureteral calculi; therefore, urologists should be aware of the potentially confusing radiographic images...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29675280/what-can-happen-when-postpartum-anxiety-progresses-to-psychosis-a-case-study
#12
Vesna Pirec
This case report describes a primipara without documented psychiatric history prior to complicated delivery. Onset of severe insomnia and anxiety was right after childbirth but not treated. Obsessive thinking pattern became more prominent. The patient became depressed and sought psychiatric help four months after delivery. Insomnia was then treated pharmacologically. Anxiety and depression persisted, suicidal ideation emerged, and the patient became confused, indecisive, overwhelmed, and delusional regarding her child's health...
2018: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29674930/a-new-lectotype-for-passiflora-laurifolia-l
#13
Maxime Rome, Geo Coppens d'Eeckenbrugge
From the "Description des plantes d'Amérique" by Plumier, in 1693, to the "Species Plantarum" by Linnaeus in 1753, several dubious synonymies of Passiflora laurifolia L. were proposed, generating a persisting confusion. A revision of the process, which led to the Linnaean description of this species, shows that the type finally chosen by Cusset does not match the original description. A new lectotype for the species and a more complete description are proposed from field observations, herbarium and bibliographic data...
2018: PhytoKeys
https://www.readbyqxmd.com/read/29674927/two-new-species-and-two-new-records-of-artabotrys-annonaceae-from-thailand
#14
Junhao Chen, Piya Chalermglin, Richard M K Saunders
Two new species of Artabotrys are described from Thailand. Artabotrys tanaosriensis J.Chen, Chalermglin & R.M.K.Saunders, sp. nov. , is similar to A. oblanceolatus Craib but differs in its symmetrical, cuneate or decurrent leaf base, externally distinct outer petal blades and claws, deltoid and undulate outer petal blades, rhomboid and undulate inner petal blades and shorter, subsessile and slightly beaked monocarps. Artabotrys spathulatus J.Chen, Chalermglin & R.M.K.Saunders, sp. nov. , is most similar to A...
2018: PhytoKeys
https://www.readbyqxmd.com/read/29673749/-k%C3%A3-bner-renb%C3%A3-k-wolf-phenomena-and-so-on%C3%A2-has-the-time-come-for-simplification
#15
N Kluger
Since the end of the 19th century, dermatologists have observed that skin conditions may respond (or not) to a wide variety of skin injuries or even to other existing skin conditions. Attempts were made to name and classify such phenomena: Köbner phenomenon, Wolf's isotopic response, Renbök phenomenon, etc. However, over time, further subtleties and nuances came to be grafted onto the initial descriptions, while comparable phenomena were described using different terms, all of which resulted in considerable confusion in the literature...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29673549/tau-and-neuroinflammation-what-impact-for-alzheimer-s-disease-and-tauopathies
#16
REVIEW
Cyril Laurent, Luc Buée, David Blum
Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common type of dementia (60-80% of cases). In 2016, nearly 44 million people were affected by AD or related dementia. AD is characterized by progressive neuronal damages leading to subtle and latter obvious decline in cognitive functions including symptoms such as memory loss or confusion, which ultimately require full-time medical care. Its neuropathology is defined by the extracellular accumulation of amyloid-β (Aβ) peptide into amyloid plaques, and intraneuronal neurofibrillary tangles (NFT) consisting of aggregated hyper- and abnormal phosphorylation of tau protein...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29671680/the-dark-side-of-context-context-reinstatement-can-distort-memory
#17
Manoj K Doss, Jamila K Picart, David A Gallo
It is widely assumed that context reinstatement benefits memory, but our experiments revealed that context reinstatement can systematically distort memory. Participants viewed pictures of objects superimposed over scenes, and we later tested their ability to differentiate these old objects from similar new objects. Context reinstatement was manipulated by presenting objects on the reinstated or switched scene at test. Not only did context reinstatement increase correct recognition of old objects, but it also consistently increased incorrect recognition of similar objects as old ones...
April 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29671667/clinical-utility-of-marketing-terms-used-for-over-the-counter-dermatologic-products
#18
Emily Boozalis, Shivani Patel
BACKGROUND: Cosmetic products are commonly marketed using dermatologic terms such as "hypoallergenic," "non-comedogenic," "fragrance-free," etc. The clinical relevance of these claims can be confusing to both patients and clinicians. METHODS: A systematic review was performed from via a PubMed search of published articles from January 1985 to October 2017 to further describe and elucidate the clinical utility of a predefined list of common dermatologic terms used by pharmaceutical companies to market over the counter products...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671329/corrigendum
#19
(no author information available yet)
Corrigendum to ICRP Publication 139: Occupational radiological protection in interventional procedures. [Ann. ICRP 47(2), 2018]. DOI: 10.1177/0146645317750356 . The following error has been identified in Annex B, Paragraph B9, p. 116: [Formula: see text] In the effective dose equation, the second summation should be over R rather than T[Formula: see text] ICRP apologises for any inconvenience or confusion caused by this error.
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29671281/validation-of-caregiver-centered-delirium-detection-tools-a-systematic-review
#20
REVIEW
Brianna Rosgen, Karla Krewulak, Danielle Demiantschuk, E Wesley Ely, Judy E Davidson, Henry T Stelfox, Kirsten M Fiest
OBJECTIVES: To summarize the validity of caregiver-centered delirium detection tools in hospitalized adults and assess associated patient and caregiver outcomes. DESIGN: Systematic review. SETTING: We searched MEDLINE, EMBASE, PsycINFO, CINAHL, and Scopus from inception to May 15, 2017. PARTICIPANTS: Hospitalized adults. INTERVENTION: Caregiver-centered delirium detection tools. MEASUREMENTS: We drafted a protocol from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
April 18, 2018: Journal of the American Geriatrics Society
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