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https://www.readbyqxmd.com/read/28222142/evaluation-of-18-f-fluoro-2-deoxyglucose-fdg-positron-emission-tomography-computed-tomography-pet-ct-as-a-staging-and-monitoring-tool-for-dogs-with-stage-2-splenic-hemangiosarcoma-a-pilot-study
#1
Antonella Borgatti, Amber L Winter, Kathleen Stuebner, Ruth Scott, Christopher P Ober, Kari L Anderson, Daniel A Feeney, Daniel A Vallera, Joseph S Koopmeiners, Jaime F Modiano, Jerry Froelich
Positron Emission Tomography-Computed Tomography (PET-CT) is routinely used for staging and monitoring of human cancer patients and is becoming increasingly available in veterinary medicine. In this study, 18-fluorodeoxyglucose (18FDG)-PET-CT was used in dogs with naturally occurring splenic hemangiosarcoma (HSA) to assess its utility as a staging and monitoring modality as compared to standard radiography and ultrasonography. Nine dogs with stage-2 HSA underwent 18FDG-PET-CT following splenectomy and prior to commencement of chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28215146/molecular-characterization-and-in-silico-analysis-of-the-tissue-inhibitor-of-metalloproteinases-3-timp-3-gene-of-canine-mammary-tumor
#2
Pavan Kumar Yadav, Brijesh Singh Yadav, Padma Nibash Panigrahi, Vijay Tripathi, Navaneet Chaturvedi, Meena Kataria
BACKGROUND: Mammary tumors are the second most common tumors (after skin tumors) in female dogs (Canis lupus familiaris). Tissue Inhibitor of Metlloproteinases-3 (TIMP-3) is a matrix associated endogenous inhibitor of Matrix Metalloproteinases (MMPs). Cancer metastasis occurs as a result of imbalance between MMPs and TIMPs. TIMP-3 is involved significantly in regulation of MMPs as well as progression of canine mammary tumor. OBJECTIVE: The present study was conducted to identify the structural and functional relationship between TIMP-3 and MMP which can aid in identifying the role of these proteins in canine mammary tumor...
February 17, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28205368/cancer-as-a-contagious-disease
#3
REVIEW
H V Siddle
Contagious cancers are malignant cells that are physically transferred between individuals as a natural allograft, forming new clonal tumours. These cancers are highly unusual, but have emerged in 2 mammalian species, the dog and the Tasmanian devil, as well as 4 species of bivalve. The transfer of malignant cells in mammals should initiate a robust immune response and although invertebrates have a less complex immune system, these species still have mechanisms that should prevent engraftment and protect against cellular parasitism...
February 15, 2017: HLA
https://www.readbyqxmd.com/read/28202530/therapeutic-potential-of-bacteria-against-solid-tumors
#4
Haralampos Hatzikirou, Juan Carlos Lopez Alfonso, Sara Leschner, Siegfried Weiss, Michael Meyer-Hermann
Intentional bacterial infections can produce efficacious anti-tumor responses in mice, rats, dogs and humans. However, low overall success rates and intense side-effects prevent such approaches from being employed clinically. In this work, we titered bacteria and/or the pro-inflammatory cytokine TNF-α in a set of established murine models of cancer. To interpret the experiments conducted, we considered and calibrated a tumor-effector cell recruitment model under the influence of functional tumor-associated vasculature...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28185388/characteristics-of-extracellular-cyclic-amp-dependent-protein-kinase-as-a-biomarker-of-cancer-in-dogs
#5
D H Bhang, U S Choi, B G Kim, S-N Lee, S Lee, H-S Roh, W-J Chung, K O Jeon, W J Song, H-Y Youn, K-H Baek
OBJECTIVE: Early and proper diagnosis of cancer is the most critical factor for the survival and treatment of veterinary cancer patients. In this study, we evaluated extracellular cyclic AMP-dependent protein kinase A (ECPKA) level in serum as a useful cancer biomarker in dogs. METHODS: ECPKA levels were detected in sera from dogs with cancers (n = 48), benign tumours (n = 18), and non-tumour diseases (n = 102) as well as healthy control dogs (n = 54) utilizing enzyme-linked immunosorbent assay (ELISA)...
February 9, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28185344/incidental-and-nonincidental-canine-thyroid-tumors-assessed-by-multidetector-row-computed-tomography-a-single-centre-cross-sectional-study-in-4520-dogs
#6
Giovanna Bertolini, Michele Drigo, Luca Angeloni, Marco Caldin
Thyroid nodules are common in dogs and are increasingly likely to be detected with the increased use of advanced imaging modalities. An unsuspected, nonpalpable, asymptomatic lesion, defined as a thyroid incidentaloma, may be discovered on an imaging study unrelated to the thyroid gland. The objective of this single-center cross-sectional study was to assess the prevalence and computed tomography (CT) characteristics of incidental and nonincidental thyroid tumors in a large population of dogs, using prospective recruitment of patients undergoing CT examination for various reasons during the period of 2005-2015...
February 9, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28163271/intestinal-gastrointestinal-stromal-tumor-in-a-cat
#7
Akihisa Suwa, Tetsuya Shimoda
A 12-year-old, 3.6-kg, spayed female domestic shorthaired cat had a 2-month history of anorexia and weight loss. Abdominal ultrasonography and computed tomography revealed an exophytic mass originating from the jejunum with very poor central and poor peripheral contrast enhancement. On day 14, surgical resection of the jejunum and mass with 5-cm margins and an end-to-end anastomosis were performed. Histopathological examination revealed the mass was a transmural, invasive cancer showing exophytic growth and originating from the small intestinal muscle layer...
February 4, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28159233/expression-and-activation-of-platelet-derived-growth-factor-%C3%AE-receptor-mitogen-activated-protein-extracellular-signal-regulated-kinase-kinase-mek-and-extracellular-signal-regulated-kinase-erk-in-canine-mammary-tumours
#8
Gennaro Altamura, Barbara Degli Uberti, Giorgio Galiero, Manuela Martano, Antonella Pirro, Marco Russo, Giuseppe Borzacchiello
Canine mammary tumours are frequent neoplasms mostly affecting intact female dogs, for which no 100% efficient therapy is available. Platelet derived growth factor β receptor (PDGFβR) is a tyrosine kinase receptor (TKR) with a potential role in human breast cancer and a series of canine tumours. In this study we demonstrated, for the first time, expression of PDGFβR and its downstream transduction molecules, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) and extracellular signal-regulated kinase (ERK), as well as their activated forms in canine mammary tumours by both biochemical analysis and immunohistochemistry...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28156488/new-primary-palliative-care-pc-model-for-community-cancer-clinics-ccc
#9
Deborah Gray, Stephanie Struve, Carol Huibregtse, Qiaofang Chen
: 159 Background: Our CCC serving a mixed rural/urban population is part of a large integrated healthcare system in Eastern WI. The closest PC specialist/team is 45 miles away at one of the tertiary care facilities. To fill this service gap we implemented a primary PC model. An initial outpatient palliative care family conference (OFC) and use of cancer nurse navigators (CNN)are hallmarks of this program. METHODS: The VLCC, housed in a standalone facility is staffed by two medical oncologists and one radiation oncologist and has an infusion center and a full-fledged radiation oncology unit with support staff, including cancer nurse navigators, research nurses, social workers, a clinical psychologist, a pharmacist, a nutritionist, a therapy dog and a chaplain...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150469/targeting-canine-mammary-tumours-via-gold-nanoparticles-functionalized-with-promising-co-ii-and-zn-ii-compounds
#10
L R Raposo, C Roma-Rodrigues, J Jesus, L M D R S Martins, A J Pombeiro, P V Baptista, A R Fernandes
BACKGROUND: Despite continuous efforts, the treatment of canine cancer has still to deliver effective strategies. For example, traditional chemotherapy with doxorubicin and/or docetaxel does not significantly increase survival in dogs with canine mammary tumors (CMTs). AIMS: Evaluate the efficiency of two metal compounds [Zn(DION)2 ]Cl (TS262, DION = 1,10-phenanthroline-5,6-dione) and [CoCl(H2 O)(DION)2 ][BF4 ] (TS265) and novel nanovectorizations designed to improve the anti-cancer efficacy of these compounds in a new CMT derived cell line (FR37-CMT)...
February 2, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28143530/a-first-immunohistochemistry-study-of-transketolase-and-transketolase-like-1-expression-in-canine-hyperplastic-and-neoplastic-mammary-lesions
#11
Giovanni Pietro Burrai, Alessandro Tanca, Tiziana Cubeddu, Marcello Abbondio, Marta Polinas, Maria Filippa Addis, Elisabetta Antuofermo
BACKGROUND: Canine mammary tumors represent the most common neoplasm in female dogs, and the discovery of cancer biomarkers and their translation to clinical relevant assays is a key requirement in the war on cancer. Since the description of the 'Warburg effect', the reprogramming of metabolic pathways is considered a hallmark of pathological changes in cancer cells. In this study, we investigate the expression of two cancer-related metabolic enzymes, transketolase (TKT) and transketolase-like 1 (TKTL1), involved in the pentose phosphate pathway (PPP), an alternative metabolic pathway for glucose breakdown that could promote cancer by providing the precursors and energy required for rapidly growing cells...
January 31, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28133886/somatic-snps-of-the-brca2-gene-at-the-fragments-encoding-rad51-binding-sites-of-canine-mammary-tumors
#12
O Ozmen, S Kul, A Risvanli, G Ozalp, A Sabuncu, O Kul
Mammary tumors are the most common tumor type both in women and in female dogs. In women, heritable breast cancers have been linked mutations in the breast cancer susceptibility gene BRCA2 and it contains eight BRC repeats in exon 11 that bind to RAD51. In this study, we investigated the sequence variations of BRC1-BRC8 and C-terminus of canine BRCA2 gene. From a total of 64 canine patients with mammary tumors, 31 mammary tumors with benign and malign carcinomas and the 3 normal mammary glands were used for the study...
January 30, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28133740/toxicity-of-metronomic-cyclophosphamide-chemotherapy-in-a-uk-population-of-cancer-bearing-dogs-a-retrospective-study
#13
A Harper, L Blackwood
OBJECTIVES: The objective of this study was to assess the incidence of toxicity in a group of cancer-bearing dogs treated with metronomic chemotherapy. MATERIALS AND METHODS: Retrospective review of dogs treated with metronomic doses of cyclophosphamide: between 5 and 15 mg/m(2) /day or every other day for treatment of neoplasia. RESULTS: Of the 65 dogs included, there were signs of, mostly mild, toxicity in 32 (49%). The most common toxicities were sterile haemorrhagic cystitis (n=16) and gastrointestinal disorders (n=12)...
January 30, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28127390/weird-genotypes-don-t-discard-them-transmissible-cancer-could-be-an-explanation
#14
Florentine Riquet, Alexis Simon, Nicolas Bierne
Genetic chimerism is rarely considered in the analysis of population genetics data, because assumed to be an exceptionally rare, mostly benign, developmental accident. An unappreciated source of chimerism is transmissible cancer, when malignant cells have become independent parasites and can infect other individuals. Parasitic cancers were thought to be rare exceptions, only reported in dogs (Murgia et al., Cell, 2006, 126, 477; Rebbeck et al., Evolution, 2009, 63, 2340), Tasmanian devils (Pearse and Swift, Nature, 2006, 439, 549; Pye et al...
February 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28123715/antiproliferative-effect-of-berberine-on-canine-mammary-gland-cancer-cell-culture
#15
Reyhaneh Sefidabi, Pejman Mortazavi, Saeed Hosseini
Canine mammary gland tumors are the most frequent cause of cancer in female dogs. Numerous studies using cancer cell lines and clinical trials have indicated that various natural products and antioxidants reduce or possibly prevent the development of cancer. Berberine (BBR), the most important alkaloid in the Berberidaceae, which exerts a wide range of pharmacological and biochemical effects, has drawn much attention due to its particularly high antitumor activity in vitro and in animal studies. The aim of the present study was to investigate the antiproliferative effect of BBR against a canine mammary gland carcinoma cell line (CF41...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28122528/a-non-invasive-tool-for-detecting-cervical-cancer-odor-by-trained-scent-dogs
#16
Héctor Guerrero-Flores, Teresa Apresa-García, Ónix Garay-Villar, Alejandro Sánchez-Pérez, David Flores-Villegas, Artfy Bandera-Calderón, Raúl García-Palacios, Teresita Rojas-Sánchez, Pablo Romero-Morelos, Verónica Sánchez-Albor, Osvaldo Mata, Víctor Arana-Conejo, Jesús Badillo-Romero, Keiko Taniguchi, Daniel Marrero-Rodríguez, Mónica Mendoza-Rodríguez, Miriam Rodríguez-Esquivel, Víctor Huerta-Padilla, Andrea Martínez-Castillo, Irma Hernández-Gallardo, Ricardo López-Romero, Cindy Bandala, Juan Rosales-Guevara, Mauricio Salcedo
BACKGROUND: Cervical Cancer (CC) has become a public health concern of alarming proportions in many developing countries such as Mexico, particularly in low income sectors and marginalized regions. As such, an early detection is a key medical factor in improving not only their population's quality of life but also its life expectancy. Interestingly, there has been an increase in the number of reports describing successful attempts at detecting cancer cells in human tissues or fluids using trained (sniffer) dogs...
January 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28120417/pd-1-expression-by-canine-t-cells-and-functional-effects-of-pd-1-blockade
#17
J Coy, A Caldwell, L Chow, A Guth, S Dow
The co-inhibitory checkpoint molecule programmed death receptor 1 (PD-1) can trigger T cell functional exhaustion upon binding to its ligand PD-L1 expressed on tumour cells or macrophages. PD-1 blocking antibodies have generated remarkable results in human cancer patients, including inducing durable responses in a number of advanced cancers. Therefore, monoclonal antibodies specific for canine PD-1 were assessed for T cell binding and induction of functional activation. A total of 5-10% of CD4 T cells and 20-25% of CD8 T cells from healthy dogs expressed PD-1, and PD-1 expression was upregulated on T cells from dogs with cancer...
January 25, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28109246/sensitivity-of-osteosarcoma-cells-to-hdac-inhibitor-ar-42-mediated-apoptosis
#18
Sridhar Murahari, Aimee L Jalkanen, Samuel K Kulp, Ching-Shih Chen, Jaime F Modiano, Cheryl A London, William C Kisseberth
BACKGROUND: Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs and is the second leading cause of cancer related deaths in children and young adults. Limb sparing surgery along with chemotherapy has been the mainstay of treatment for OS. Many patients are not cured with current therapies, presenting a real need for developing new treatments. Histone deacetylase (HDAC) inhibitors are a promising new class of anticancer agents. In this study, we investigated the activity of the novel HDAC inhibitor AR-42 in a panel of human and canine OS cell lines...
January 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28105582/-control-of-opisthorchis-viverrini-infection-for-cholangiocarcinoma-prevention
#19
Y Buisson
The International Agency for Research on Cancer (IARC) has classified two liver flukes as carcinogenic to humans (Group 1): Opisthorchis viverrini in 1994 and Clonorchis sinensis in 2009. This review is focused on O. viverrini, the most studied of these two trematodes, which infects nearly 10 million people in Southeast Asia. The life cycle involves two intermediate hosts living in fresh water: a snail of the genus Bithynia and a ciprinid fish. The definitive hosts (human, cat, dog) become infected by ingesting raw fish containing metacercariae, the infective stage of the parasite...
January 19, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28088915/evaluation-of-microrna-stability-in-plasma-and-serum-from-healthy-dogs
#20
Lars Enelund, Lise Nikolic Nielsen, Susanna Cirera
BACKGROUND: Early and specific detection of cancer is of great importance for successful treatment of the disease. New biomarkers, like microRNAs, could improve treatment efficiency and survival ratio. In human medicine, deregulation of microRNA profiles in circulation has shown great potential as a new type of biomarker for cancer diagnostics. There are, however, few studies of circulating microRNAs in dogs. Extracellular circulating microRNAs have shown a high level of stability in human blood and other body fluids...
January 13, 2017: MicroRNA
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