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https://www.readbyqxmd.com/read/29137329/development-of-a-radiolabeled-caninized-anti-egfr-antibody-for-comparative-oncology-trials
#1
Judit Fazekas-Singer, Neydher Berroterán-Infante, Christina Rami-Mark, Monika Dumanic, Miroslawa Matz, Michael Willmann, Fritz Andreae, Josef Singer, Wolfgang Wadsak, Markus Mitterhauser, Erika Jensen-Jarolim
Due to large homology of human and canine EGFR, dogs suffering from spontaneous EGFR+ cancer can be considered as ideal translational models. Thereby, novel immunotherapeutic compounds can be developed for both human and veterinary patients. This study describes the radiolabeling of a canine anti-EGFR IgG antibody (can225IgG) with potential diagnostic and therapeutic value in comparative clinical settings. Can225IgG was functionalized with DTPA for subsequent chelation with the radionuclide (99m)Tc. Successful coupling of 10 DTPA molecules per antibody on average was proven by significant mass increase in MALDI-TOF spectroscopy, gel electrophoresis and immunoblots...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134653/association-between-environmental-factors-including-second-hand-smoke-and-primary-lung-cancer-in-dogs
#2
A Zierenberg-Ripoll, R E Pollard, S L Stewart, S D Allstadt, L E Barrett, J M Gillem, K A Skorupski
OBJECTIVES: To estimate prevalence of exposure to environmental tobacco smoke and other environmental toxins in dogs with primary lung tumours and to analyse association between exposure and lung tumour development. MATERIALS AND METHODS: In this case-control study, an owner survey was developed to collect data on patient characteristics, general health care and environmental exposures. Dogs diagnosed with primary lung carcinomas formed the Case group. Dogs diagnosed with mast cell tumours served as Control Group 1 and dogs diagnosed with neurologic disease served as Control Group 2...
November 14, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29127382/birth-of-clones-of-the-world-s-first-cloned-dog
#3
Min Jung Kim, Hyun Ju Oh, Geon A Kim, Erif Maha Nugraha Setyawan, Yoo Bin Choi, Seok Hee Lee, Simon M Petersen-Jones, CheMyong J Ko, Byeong Chun Lee
Animal cloning has gained popularity as a method to produce genetically identical animals or superior animals for research or industrial uses. However, the long-standing question of whether a cloned animal undergoes an accelerated aging process is yet to be answered. As a step towards answering this question, we compared longevity and health of Snuppy, the world's first cloned dog, and its somatic cell donor, Tai, a male Afghan hound. Briefly, both Snuppy and Tai were generally healthy until both developed cancer to which they succumbed at the ages of 10 and 12 years, respectively...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119511/a-method-for-cross-species-visualization-and-analysis-of-rna-sequence-data
#4
Stephen A Ramsey
In this methods article, I describe a computational workflow for cross-species visualization and comparison of mRNA-seq transcriptome profiling data. The workflow is based on gene set variation analysis (GSVA) and is illustrated using commands in the R programming language. I provide a complete step-by-step procedure for the workflow using mRNA-seq data sets from dog and human bladder cancer as an example.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29116175/sniffer-mice-discriminate-urine-odours-of-patients-with-bladder-cancer-a-proof-of-principle-study-for-non-invasive-diagnosis-of-cancer-induced-odours
#5
Takaaki Sato, Yoji Katsuoka, Kimihiko Yoneda, Mitsuo Nonomura, Shinya Uchimoto, Reiko Kobayakawa, Ko Kobayakawa, Yoichi Mizutani
Similar to fingerprints, humans have unique, genetically determined body odours. In case of urine, the odour can change due to variations in diet as well as upon infection or tumour formation. We investigated the use of mice in a manner similar to "sniffer dogs" to detect changes in urine odour in patients with bladder cancer. We measured the odour discrimination thresholds of mice in a Y-maze, using urine mixtures from patients with bladder cancer (Stage I) and healthy volunteers (dietary variations) as well as occult blood- or antibiotic drug metabolite-modulated samples...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115935/microrna-expression-patterns-in-canine-mammary-cancer-show-significant-differences-between-metastatic-and-non-metastatic-tumours
#6
Malgorzata Bulkowska, Agata Rybicka, Kerem Mert Senses, Katarzyna Ulewicz, Katarzyna Witt, Joanna Szymanska, Bartlomiej Taciak, Robert Klopfleisch, Eva Hellmén, Izabella Dolka, Ali O Gure, Joanna Mucha, Mariusz Mikow, Slawomir Gizinski, Magdalena Krol
BACKGROUND: MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have been found for canine mammary cancer and human breast cancer. On account of this, large-scale profiling of microRNA expression in canine mammary cancer seems to be important for both dogs and humans. METHODS: Expression profiles of 317 microRNAs in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases) and in 25 control samples were evaluated...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29113646/effects-of-recombinant-canine-interferon-%C3%AE-injected-before-general-anesthesia-with-propofol-and-isoflurane-on-natural-killer-cytotoxic-activity-during-anesthesia-in-dogs
#7
Hirotaka Matsumoto, Takuma Miyata, Tomoko Ohkusa, Takahiro Teshima, Hidekazu Koyama
We aimed to determine whether subcutaneous injection of recombinant canine interferon-γ (rCaIFN-γ) 1h before general anesthesia with a combination of propofol and isoflurane (P-I) changes the cytotoxic activity of natural killer (NK) cells during anesthesia in dogs. Nine clinically healthy beagles were assigned to one of two groups: rCaIFN-γ-treated group (n=5) and control group (no treatment, n=4). One hour before P-I anesthesia, rCaIFN-γ was subcutaneously injected at a dose of 1×10(4)U/kg body weight for the test group and physiologic saline was subcutaneously injected for the control group...
October 26, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29113289/synergistic-and-targeted-therapy-with-a-procaspase-3-activator-and-temozolomide-extends-survival-in-glioma-rodent-models-and-is-feasible-for-the-treatment-of-canine-malignant-glioma-patients
#8
Avadhut D Joshi, Rachel C Botham, Lisa J Schlein, Howard S Roth, Antonella Mangraviti, Alexandra Borodovsky, Betty Tyler, Steve Joslyn, Jayme S Looper, Michael Podell, Timothy M Fan, Paul J Hergenrother, Gregory J Riggins
Purpose: Glioblastoma is a deadly brain cancer with a median survival time of ∼15 months. Ionizing radiation plus the DNA alkylator temozolomide (TMZ) is the current standard therapy. PAC-1, a procaspase-3 activating small molecule, is blood-brain barrier penetrant and has previously demonstrated ability to synergize with diverse pro-apoptotic chemotherapeutics. We studied if PAC-1 could enhance the activity of TMZ, and whether addition of PAC-1 to standard treatment would be feasible in spontaneous canine malignant gliomas...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105159/a-6-bp-deletion-variant-in-a-novel-canine-glutathione-s-transferase-gene-gstt5-leads-to-loss-of-enzyme-function
#9
S Craft, J Ekena, J Sacco, K Luethcke, L Trepanier
OBJECTIVES: Glutathione-S-transferases (GSTs) detoxify reactive xenobiotics, and defective GST gene polymorphisms increase cancer risk in humans. A low activity GST-theta variant was previously found in research beagles. The purpose of our study was to determine the molecular basis for this phenotype and its allele frequency in pet dogs. METHODS: Banked livers from 45 dogs of various breeds were screened for low GST-theta activity by the substrate 1,2-dichloro-4-nitrobenzene (DCNB), and were genotyped for variants in a novel canine GST gene, GSTT5...
November 3, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29098941/efflux-transporter-breast-cancer-resistance-protein-dominantly-expresses-on-the-membrane-of-red-blood-cells-hinders-partitioning-of-its-substrates-into-the-cells-and-alters-drug-drug-interaction-profiles
#10
Pu Shi, Mingxiang Liao, Bei-Ching Chuang, Robert Griffin, Judy Shi, Marc Hyer, John K Fallon, Philip C Smith, Chao Li, Cindy Q Xia
1. Red blood cell (RBC) partitioning is important in determining pharmacokinetic and pharmacodynamic properties of a compound; however, active transport across RBC membranes is not well understood, particularly without transporter-related cell membrane proteomics data. 2. In this study, we quantified breast cancer resistance protein (BCRP/Bcrp) and MDR1/P-glycoprotein (P-gp) protein expression in RBCs from humans, monkeys, dogs, rats, and mice using nanoLC/MS/MS, and evaluated their effect on RBC partitioning and plasma exposure of their substrates...
November 3, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29090969/expression-of-cat-podoplanin-in-feline-squamous-cell-carcinomas
#11
Shunsuke Itai, Shinji Yamada, Mika K Kaneko, Hiroyuki Harada, Yumiko Kagawa, Satoru Konnai, Yukinari Kato
Oral squamous cell carcinoma is an aggressive tumor in cats; however, molecular-targeted therapies against this tumor, including antibody therapy, have not been developed. Sensitive and specific monoclonal antibodies (mAbs) against highly expressed membrane proteins are needed to develop antibody therapies. Podoplanin, a type I transmembrane glycoprotein, is expressed in many human malignant tumors, including brain tumor, esophageal cancer, lung cancer, mesothelioma, and oral cancer. Podoplanin binds to C-type lectin-like receptor-2 (CLEC-2) and activates platelet aggregation, which is involved in cancer metastasis...
November 1, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29080252/clinical-evaluation-of-tavocept-to-decrease-diuresis-time-and-volume-in-dogs-with-bladder-cancer-receiving-cisplatin
#12
C J Henry, B K Flesner, S A Bechtel, J N Bryan, D J Tate, K A Selting, J C Lattimer, M E Bryan, L Grubb, F Hausheer
BACKGROUND: Transitional cell carcinoma is the most common bladder cancer of dogs. Cisplatin combined with piroxicam provides superior response rates, but unacceptable rates of nephrotoxicity. Tavocept is a chemoprotectant that has mitigated cisplatin toxicity and decreased the required infusion/diuresis volume in clinical trials in humans. HYPOTHESIS/OBJECTIVES: We hypothesized that Tavocept would decrease diuresis volume and time and facilitate safe administration of a cisplatin/piroxicam protocol to dogs with bladder cancer...
October 27, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29076241/oncolytic-reovirus-therapy-pilot-study-in-dogs-with-spontaneously-occurring-tumours
#13
C C Hwang, M Igase, M Sakurai, T Haraguchi, K Tani, K Itamoto, T Shimokawa, M Nakaichi, Y Nemoto, S Noguchi, M Coffey, M Okuda, T Mizuno
Oncolytic virotherapy is a novel treatment involving replication-competent virus in the elimination of cancer. We have previously reported the oncolytic effects of reovirus in various canine cancer cell lines. This study aims to establish the safety profile of reovirus in dogs with spontaneously occurring tumours and to determine a recommended dosing regimen. Nineteen dogs with various tumours, mostly of advanced stages, were treated with reovirus, ranging from 1.0 × 10(8) to 5.0 × 10(9) TCID50 given as intratumour injection (IT) or intravenous infusion (IV) daily for up to 5 consecutive days in 1 or multiple treatment cycles...
October 27, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29069885/internal-mammary-artery-perforator-flap-for-immediate-volume-replacement-following-wide-local-excision-of-breast-cancer
#14
Martine A van Huizum, J Joris Hage, Hester A Oldenburg, Marije J Hoornweg
Background: Breast-conserving therapy is defined as a breast-conserving wide local excision (WLE) of a mammary tumour combined with postoperative radiotherapy. Immediate restoration of the mammary shape by use of breast reduction techniques (volume displacement) or tissue replacement techniques (volume replacement) is gaining popularity to prevent breast malformation. Methods: To date, using the internal mammary artery perforator (IMAP) flap has been suggested for immediate volume replacement after WLE, but has never been evaluated in a published study...
October 26, 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29067210/pilot-study-of-safety-and-feasibility-of-dna-microseeding-for-treatment-of-spontaneous-canine-melanoma
#15
Cindy L Zuleger, Chulhi Kang, Erik A Ranheim, Ilene D Kurzman, Michael D Macklin, Michael A Newton, Jedd D Wolchok, David M Vail, Elof Eriksson, Mark R Albertini
Spontaneous canine malignant melanoma provides an excellent pre-clinical model to study DNA vaccines for melanoma immunotherapy. A USDA-approved xenogeneic human tyrosinase (huTYR) plasmid DNA vaccine delivered intramuscularly induces detectable immune responses and has clinical activity in some dogs with melanoma. The objective of this pilot study was to evaluate the feasibility, safety and immunogenicity of huTYR plasmid DNA administered to the skin via microseeding in dogs with spontaneous melanoma. DNA microseeding utilizes a modified tattooing device as an alternate and potentially more potent delivery method for DNA immunization...
August 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29066513/comparative-transcriptome-analysis-quantifies-immune-cell-transcript-levels-metastatic-progression-and-survival-in-osteosarcoma
#16
Milcah C Scott, Nuri A Temiz, Anne E Sarver, Rebecca S LaRue, Susan K Rathe, Jyotika Varshney, Natalie K Wolf, Branden S Moriarity, Timothy D O'Brien, Logan G Spector, David A Largaespada, Jaime F Modiano, Subbaya Subramanian, Aaron L Sarver
Overall survival of patients with osteosarcoma (OS) has improved little in the past three decades and better models for study are needed. OS is common in large dog breeds and is genetically inducible in mice, making the disease ideal for comparative genomic analyses across species. Understanding the level of conservation of inter-tumor transcriptional variation across species and how it is associated with progression to metastasis will enable us to more efficiently develop effective strategies to manage OS and improve therapy...
October 24, 2017: Cancer Research
https://www.readbyqxmd.com/read/29065898/comparative-review-of-human-and-canine-osteosarcoma-morphology-epidemiology-prognosis-treatment-and-genetics
#17
REVIEW
Siobhan Simpson, Mark David Dunning, Simone de Brot, Llorenç Grau-Roma, Nigel Patrick Mongan, Catrin Sian Rutland
Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA survival rates in people not having improved in decades. For dogs, 1 year survival rates are only around ~ 45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease...
October 24, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29063312/canine-invasive-mammary-carcinomas-as-models-of-human-breast-cancer-part-2-immunophenotypes-and-prognostic-significance
#18
Jérôme Abadie, Frédérique Nguyen, Delphine Loussouarn, Laura Peña, Adelina Gama, Natascha Rieder, Anton Belousov, Ingrid Bemelmans, Laëtitia Jaillardon, Catherine Ibisch, Mario Campone
PURPOSE: Relevant animal models of human breast cancer are currently needed, especially for the aggressive triple-negative breast cancer subtype. Recent studies and our results (Part 1) indicate that spontaneous canine invasive mammary carcinomas (CMCs) resemble human breast cancer by clinics and pathology as well as behavior and prognostic indicators. We hypothesized that the current molecular classifications of human breast cancer, used for therapeutic decision, could be relevant to dogs...
October 23, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29046813/single-nucleotide-polymorphisms-and-microsatellites-in-the-canine-glutathione-s-transferase-pi-1-gstp1-gene-promoter
#19
James Sacco, Sarah Mann, Keller Toral
BACKGROUND: Genetic polymorphisms within the glutathione S-transferase P1 (GSTP1) gene affect the elimination of toxic xenobiotics by the GSTP1 enzyme. In dogs, exposure to environmental chemicals that may be GSTP1 substrates is associated with cancer. The objectives of this study were to investigate the genetic variability in the GSTP1 promoter in a diverse population of 278 purebred dogs, compare the incidence of any variants found between breeds, and predict their effects on gene expression...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/29027689/oral-mucosa-model-for-electrochemotherapy-treatment-of-dog-mouth-cancer-ex-vivo-in-silico-and-in-vivo-experiments
#20
Daniela O H Suzuki, José A Berkenbrock, Marisa J S Frederico, Fátima R M B Silva, Marcelo M M Rangel
Electrochemotherapy (EQT) is a local cancer treatment well established to cutaneous and subcutaneous tumors. Electric fields are applied to biological tissue in order to improve membrane permeability for cytotoxic drugs. This phenomenon is called electroporation or electropermeabilization. Studies have reported that tissue conductivity is electric field dependent. Electroporation numerical models of biological tissues are essential in treatment planning. Tumors of the mouth are very common in dogs. Inadequate EQT treatment of oral tumor may be caused by significant anatomic variations between dogs and tumor position...
October 13, 2017: Artificial Organs
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