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https://www.readbyqxmd.com/read/27906156/biomimetic-sniffing-improves-the-detection-performance-of-a-3d-printed-nose-of-a-dog-and-a-commercial-trace-vapor-detector
#1
Matthew E Staymates, William A MacCrehan, Jessica L Staymates, Roderick R Kunz, Thomas Mendum, Ta-Hsuan Ong, Geoffrey Geurtsen, Greg J Gillen, Brent A Craven
Unlike current chemical trace detection technology, dogs actively sniff to acquire an odor sample. Flow visualization experiments with an anatomically-similar 3D printed dog's nose revealed the external aerodynamics during canine sniffing, where ventral-laterally expired air jets entrain odorant-laden air toward the nose, thereby extending the "aerodynamic reach" for inspiration of otherwise inaccessible odors. Chemical sampling and detection experiments quantified two modes of operation with the artificial nose-active sniffing and continuous inspiration-and demonstrated an increase in odorant detection by a factor of up to 18 for active sniffing...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893789/characterization-of-the-canine-mhc-class-i-dla-88-50101-peptide-binding-motif-as-a-prerequisite-for-canine-t-cell-immunotherapy
#2
Sharon M Barth, Christian M Schreitmüller, Franziska Proehl, Kathrin Oehl, Leonie M Lumpp, Daniel J Kowalewski, Moreno Di Marco, Theo Sturm, Linus Backert, Heiko Schuster, Stefan Stevanović, Hans-Georg Rammensee, Oliver Planz
There are limitations in pre-clinical settings using mice as a basis for clinical development in humans. In cancer, similarities exist between humans and dogs; thus, the dog patient can be a link in the transition from laboratory research on mouse models to clinical trials in humans. Knowledge of the peptides presented on MHC molecules is fundamental for the development of highly specific T cell-based immunotherapies. This information is available for human MHC molecules but is absent for the canine MHC. In the present study, we characterized the binding motif of dog leukocyte antigen (DLA) class I allele DLA-88*50101, using human C1R and K562 transfected cells expressing the DLA-88*50101 heavy chain...
2016: PloS One
https://www.readbyqxmd.com/read/27890405/platelets-inhibit-migration-of-canine-osteosarcoma-cells
#3
S C Bulla, P R Badial, R C Silva, K Lunsford, C Bulla
The interaction between platelets and tumour cells is important for tumour growth and metastasis. Thrombocytopenia or antiplatelet treatment negatively impact on cancer metastasis, demonstrating potentially important roles for platelets in tumour progression. To our knowledge, there is no information regarding the role of platelets in cancer progression in dogs. This study was designed to test whether canine platelets affected the migratory behaviour of three canine osteosarcoma cell lines and to give insights of molecular mechanisms...
November 24, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27886411/dog-ownership-and-physical-activity-among-breast-prostate-and-colorectal-cancer-survivors
#4
Cynthia C Forbes, Chris M Blanchard, W Kerry Mummery, Kerry S Courneya
BACKGROUND: Dog ownership has been associated with higher rates of physical activity (PA) in several populations but no study to date has focused on cancer survivors. The purpose of this study was to examine the associations between dog ownership and PA among cancer survivors; and to examine correlates of dog ownership. METHODS: A stratified random sample of 2062 breast (BCS), prostate (PCS), and colorectal cancer survivors (CRCS) was mailed a questionnaire assessing PA, social-cognitive, dog ownership, demographic, and medical variables...
November 25, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27879443/skeletal-metastasis-of-canine-urothelial-carcinoma-pathologic-and-computed-tomographic-features
#5
V A Charney, M A Miller, H G Heng, H Y Weng, D W Knapp
Invasive urothelial (transitional cell) carcinoma (UC) is the most common cancer in the canine urinary tract. Prolonged survival of dogs with UC due to better management of the primary tumor and prevention of urethral obstruction might have contributed to an apparent increase in distant metastasis. Metastasis to bone is particularly concerning because the ensuing pain often leads to euthanasia; however, little is known of the frequency, site, or nature of UC skeletal metastasis. In a retrospective analysis, 17 (9%) of 188 canine UC cases had histologically confirmed skeletal metastasis, mainly to the vertebrae...
November 22, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27863558/development-of-an-autologous-canine-cancer-vaccine-system-for-resectable-malignant-tumors-in-dogs
#6
J R Yannelli, R Wouda, T J Masterson, M G Avdiushko, D A Cohen
While conventional therapies exist for canine cancer, immunotherapies need to be further explored and applied to the canine setting. We have developed an autologous cancer vaccine (K9-ACV), which is available for all dogs with resectable disease. K9-ACV was evaluated for safety and immunogenicity for a variety of cancer types in a cohort of companion dogs under veterinary care. The autologous vaccine was prepared by enzymatic digestion of solid tumor biopsies. The resultant single cell suspensions were then UV-irradiated resulting in immunogenic cell death of the tumor cells...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27856424/eradication-of-canine-diffuse-large-b-cell-lymphoma-in-a-murine-xenograft-model-with-cd47-blockade-and-anti-cd20
#7
Kipp Weiskopf, Katie L Anderson, Daisuke Ito, Peter J Schnorr, Hirotaka Tomiyasu, Aaron M Ring, Kristin Bloink, Jem Efe, Sarah Rue, David Lowery, Amira Barkal, Susan Prohaska, Kelly M McKenna, Ingrid Cornax, Timothy D O'Brien, M Gerard O'Sullivan, Irving L Weissman, Jaime F Modiano
Cancer immunotherapies hold much promise, but their potential in veterinary settings has not yet been fully appreciated. Canine lymphomas are among the most common tumors of dogs and bear remarkable similarity to human disease. In this study, we examined the combination of CD47 blockade with anti-CD20 passive immunotherapy for canine lymphoma. The CD47/SIRPα axis is an immune checkpoint that regulates macrophage activation. In humans, CD47 is expressed on cancer cells and enables evasion from phagocytosis...
November 14, 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27843708/prospective-preliminary-in-vitro-investigation-of-a-magnetic-iron-oxide-nanoparticle-conjugated-with-ligand-cd80-and-vegf-antibody-as-a-targeted-drug-delivery-system-for-the-induction-of-cell-death-in-rodent-osteosarcoma-cells
#8
AnneMarie Kay Kovach, Jen M Gambino, Vina Nguyen, Zach Nelson, Taylor Szasz, Jun Liao, Lakiesha Williams, Sandra Bulla, Raj Prabhu
Target drug deliveries using nanotechnology are a novel consideration in the treatment of cancer. We present herein an in vitro mouse model for the preliminary investigation of the efficacy of an iron oxide nanoparticle complex conjugated to vascular endothelial growth factor (VEGF) antibody and ligand cluster of differentiation 80 (CD80) for the purpose of eventual translational applications in the treatment of human osteosarcoma (OSA). The 35 nm diameter iron oxide magnetic nanoparticles are functionalized with an n-hydroxysuccinimide biocompatible coating and are conjugated on the surface to proteins VEGF antibody and ligand CD80...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27843665/a-dog-is-a-doctor-s-best-friend-the-use-of-a-service-dog-as-a-perioperative-assistant
#9
Shannon Tew, Brad M Taicher
Service dogs are beneficial in providing assistance to people with multiple types of disabilities and medical disorders including visual impairment, physical disabilities, seizure disorders, diabetes, and mental illness. Some service animals have been trained as a screening tool for cancer. We review a case involving a 6-year-old female with a history of mast cell mediator release and immediate hypersensitivity due to the urticaria pigmentosa variant of cutaneous mastocytosis who underwent a cystourethroscopy...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27821712/btk-small-molecule-inhibitors-induce-a-distinct-pancreatic-toxicity-in-rats
#10
Rebecca I Erickson, Leah K Schutt, Jacqueline Tarrant, Michelle McDowell, Lichuan Liu, Adam R Johnson, Sock-Cheng Lewin-Koh, Maj Hedehus, Jed Ross, Richard A D Carano, Karin Staflin, Fiona Zhong, James Crawford, Shelly Zhong, Karin Reif, Arna Katewa, Harvey Wong, Wendy Young, Donna Dambach, Dinah Misner
Bruton's tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule inhibitors of BTK are being investigated for treatment of several hematological cancers and autoimmune diseases. GDC-0853 is a selective and reversible oral small molecule BTK inhibitor in development for the treatment of rheumatoid arthritis and systemic lupus erythematosus. In Sprague-Dawley (SD) rats, administration of GDC-0853 and other structurally diverse BTK inhibitors for 7 days or longer caused pancreatic lesions consisting of multifocal islet-centered hemorrhage, inflammation, fibrosis, and pigment-laden macrophages with adjacent lobular exocrine acinar cell atrophy, degeneration, and inflammation...
November 7, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27796918/pulmonary-artery-reconstruction-with-a-tailor-made-bovine-pericardial-conduit-following-sleeve-resection-of-a-long-segmental-pulmonary-artery-for-the-treatment-of-lung-cancer-technical-details-of-the-dog-ear-method-for-adjusting-diameter-during-vascular-anastomosis
#11
Kimihiro Shimizu, Toshiteru Nagashima, Yoichi Ohtaki, Toru Takahashi, Akira Mogi, Hiroyuki Kuwano
Sleeve resection of the pulmonary artery (PA) is always required for lung-sparing operations in which half or more of the vessel circumference is infiltrated by the primary tumor or metastatic hilar nodes. Following sleeve resection, conduit reconstruction may be indicated if there is excessive distance between the two vascular stumps, because there is a high degree of tension when repaired by direct anastomosis. We herein present a case of PA reconstruction using a tailor-made bovine pericardial conduit after sleeve resection of PA during lung cancer surgery...
October 31, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27792895/a-case-report-of-a-complete-degloving-injury-of-the-penile-skin
#12
Helena Aineskog, Fredrik Huss
INTRODUCTION: Male genital degloving injuries are unusual and rarely caused by animal bite. Usually patients attend health care immediately if bitten in the genital area. Prophylactic antibiotics is routinely used (Gomes et al., 2000). A penile degloving usually begins just proximal of the coronal line and progress down to the base of the shaft. Deep erectile tissue and the spermatic cord are seldom damaged and the endogenous skin of glans usually survives (Brown and Fryer, 1957; Morey et al...
October 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27790682/detection-of-skin-cancer-odours-using-dogs-a-step-forward-in-melanoma-detection-training-and-research-methodologies
#13
EDITORIAL
K R Elliker, H C Williams
No abstract text is available yet for this article.
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27789548/hot-dog-lymphadenopathy-of-prostate-cancer
#14
Simon Takada, Masahiro Nishimura, Kyouichi Yamaguchi, Yasuharu Tokuda
No abstract text is available yet for this article.
October 27, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27767430/a-systematic-review-of-adverse-event-reporting-in-companion-animal-clinical-trials-evaluating-cancer-treatment
#15
Michelle A Giuffrida
OBJECTIVE To evaluate methods used to ascertain, define, and report adverse events (AEs) in companion animal clinical trials involving cancer treatment. DESIGN Systematic review. SAMPLE English-language articles describing prospective clinical trials involving dogs and cats with naturally occurring cancer published in peer-reviewed journals between 2008 and 2014. PROCEDURES Reports were identified via MEDLINE and CAB database searches combined with a hand-searching strategy. General article characteristics were abstracted and summarized...
November 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27764139/prevalence-of-glomerulopathies-in-canine-mammary-carcinoma
#16
Leandro Z Crivellenti, Gyl E B Silva, Sofia Borin-Crivellenti, Rachel Cianciolo, Christopher A Adin, Márcio Dantas, Denner S Dos Anjos, Mirela Tinucci-Costa, Aureo E Santana
The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy...
2016: PloS One
https://www.readbyqxmd.com/read/27747218/the-current-state-of-clinical-application-of-serum-biomarkers-for-canine-lymphoma
#17
Jeffrey N Bryan
Serum biomarkers of canine lymphoma activity for diagnosis, prognosis, and therapy monitoring have been of clinical interest for more than a decade. Tumor products, biochemical enzymes, cytokines, metabolic profiling, leakage enzymes, as well as serum proteins have been studied as biomarkers for lymphoma. Multiple biomarkers combined have been shown to be most sensitive and specific. C-reactive protein, thymidine kinase 1, and haptoglobin have been most extensively studied and commercialized in diagnostic tests, the TK Canine Cancer Panel and the Canine Lymphoma Blood Test...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27744530/expression-of-hif-1%C3%AE-odd-domain-fused-canine-caspase-3-by-egfr-promoter-driven-adenovirus-vector-induces-cytotoxicity-in-canine-breast-tumor-cells-under-hypoxia
#18
Mariko Okamoto, Ai Asamura, Ko Tanaka, Takefumi Soeda, Kyo Watanabe, Hiroyuki Mizuguchi, Teruo Ikeda
Adenovirus (Ad) vectors are widely used in cancer gene therapies. However, compared to human patients, relatively limited information is available on gene transduction efficiency or cell-specific cytotoxicity in canine tumor cells transduced with Ad vectors. Since epidermal growth factor receptor (EGFR) is highly expressed on canine breast tumor cells, we sought to develop an Ad vector based on the RGD fiber-mutant adenovirus vector (AdRGD) that expresses canine caspase 3 under the control of EGFR promoter...
October 16, 2016: Veterinary Research Communications
https://www.readbyqxmd.com/read/27732569/comparison-of-volatile-organic-compounds-from-lung-cancer-patients-and-healthy-controls-challenges-and-limitations-of-an-observational-study
#19
Kristin Schallschmidt, Roland Becker, Christian Jung, Wolfram Bremser, Thorsten Walles, Jens Neudecker, Gunda Leschber, Steffen Frese, Irene Nehls
This paper outlines the design and performance of an observational study on the profiles of volatile organic compounds (VOCs) in the breath of 37 lung cancer patients and 23 healthy controls of similar age. The need to quantify each VOC considered as a potential disease marker on the basis of individual calibration is elaborated, and the quality control measures required to maintain reproducibility in breath sampling and subsequent instrumental trace VOC analysis using solid phase microextraction-gas chromatography-mass spectrometry over a study period of 14 months are described...
October 12, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27723224/pretreatment-leukocyte-ratios-and-concentrations-as-predictors-of-outcome-in-dogs-with-cutaneous-mast-cell-tumours
#20
O Skor, A Fuchs-Baumgartinger, A Tichy, M Kleiter, I Schwendenwein
Leukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance in mast cell tumour (MCT). The aim of the study was to evaluate the prognostic significance of pretreatment leukocyte concentrations and their ratios in dogs with MCT for survival. Medical records of 92 dogs with MCT were retrospectively reviewed. Tumour diagnosis was made by tumour biopsy or fine-needle aspirate. Only dogs without prior treatment were included. Eosinophil, lymphocyte, monocyte and neutrophil concentration were obtained by ADVIA 2120™ (Siemens Healthcare, Vienna, Austria)...
October 9, 2016: Veterinary and Comparative Oncology
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