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Abdominal Obesity

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https://www.readbyqxmd.com/read/28651075/modulation-of-natriuretic-peptide-receptors-in-human-adipose-tissue-molecular-mechanisms-behind-the-natriuretic-handicap-in-morbidly-obese-patients
#1
A Gentili, M R Frangione, E Albini, C Vacca, M A Ricci, S De Vuono, M Boni, F Rondelli, L Rotelli, G Lupattelli, C Orabona
The B-type natriuretic peptide (BNP) hormone plays a crucial role in the regulation of cardiovascular and energy homeostasis. Obesity is associated with low circulating levels of BNP, a condition known as "natriuretic handicap." Recent evidences suggest an altered expression of BNP receptors-both the signaling natriuretic peptide receptors (NPR)-A and the clearance NPR-C receptor-in adipose tissue (AT) as one of the putative causes of natriuretic handicap. The current study aims at clarifying the molecular mechanisms behind the natriuretic handicap, focusing on NPR modulation in the AT of obese and control subjects...
June 10, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28650669/visceral-adiposity-and-expression-of-clock-genes-in-peripheral-blood-mononuclear-cells-a-pilot-study
#2
Sue Kim, Hye-Sun Lee, Hyun-Ki Park, John A Linton, Ji-Won Lee, Hyangkyu Lee
Increasing evidence suggests a close interrelationship between disrupted circadian rhythms and obesity and metabolic disturbances. In particular, abdominal obesity, which contributes to the pathogenesis of metabolic disease, is associated with disrupted clock gene expression. However, little is known about the relationship between clock gene expression and accurate computed tomography (CT)-based measurements of visceral adiposity. Therefore, we examined the relationship between expression of clock genes in peripheral blood mononuclear cells (PBMCs) with visceral and subcutaneous adiposity in 75 healthy overweight or obese individuals...
June 26, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28649807/microrna-196-regulates-hox-gene-expression-in-human-gluteal-adipose-tissue
#3
Adeline Divoux, Hui Xie, Jian-Liang Li, Kalypso Karastergiou, Ranjan J Perera, R Jeffrey Chang, Susan K Fried, Steven R Smith
OBJECTIVE: Lower body fat is associated with diminishing cardiometabolic risk. Physiological differences between gluteofemoral and abdominal subcutaneous adipocyte functions are known, but the molecular basis for depot differences in adipocyte function is poorly understood. The objective of this study was to identify depot differences in microRNA (miRNA) expression in human abdominal and gluteofemoral subcutaneous adipose tissues and their implication in gene regulation. METHODS: Abdominal and gluteofemoral adipose tissue aspirates obtained from 18 participants (9 male and 9 female, age 30 ± 1...
June 25, 2017: Obesity
https://www.readbyqxmd.com/read/28649655/gene-expression-in-breast-and-adipose-tissue-after-12-months-of-weight-loss-and-vitamin-d-supplementation-in-postmenopausal-women
#4
Caitlin Mason, Lei Wang, Catherine Duggan, Ikuyo Imayama, Sushma S Thomas, Ching-Yun Wang, Larissa A Korde, Anne McTiernan
Adipose tissue is involved in the etiology of postmenopausal breast cancer, possibly through increased sex steroid hormone production, inflammation, and altered adipokines. Vitamin D may affect these pathways but its effect on gene expression in different tissues has not been examined. Within a double-blind, 12-month placebo-controlled randomized trial, we compared 2000 IU/day oral vitamin D3 supplementation (N = 39) vs. placebo (N = 40) on the expression of 5 genes in breast and adipose tissue in overweight/obese postmenopausal women (50-75 years)...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28647969/-knowledge-attitude-and-practice-to-chronic-diseases-and-associated-influencing-factors-in-uygur-population-in-kashgar-area-of-xinjiang-uygur-autonomous-region
#5
Z B Zhang, Z X Xue, M M Ma, Y H Li, D M Luo, X L Song, X F Chao, G Wang, Nurmamat Nazibam, Bawudun Ayxamgul, Mahat Sulayman, X J Wu, Z Y Zhou, B S Sun, Y Z Wang, M Wang
Objective: To investigate the knowledge, attitude and practice (KAP) to chronic diseases and associated influencing factors in Uygur adults in Kashgar of southern Xinjiang, and provide basic information for developing ethnic specific prevention and control strategies for chronic diseases. Methods: With stratified cluster random sampling, investigations, including questionnaire survey, physical examination and laboratory tests were performed among local residents who were aged ≥18 years and selected in Shufu county in southern Xinjiang...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647967/-prevalence-of-dyslipidemia-and-normal-blood-lipids-level-in-uygur-population-in-kashgar-area-of-xinjiang-uygur-autonomous-region
#6
Z B Zhang, Z X Xue, X J Wu, T M Wang, Y H Li, X L Song, X F Chao, G Wang, Nurmamat Nazibam, Bawudun Ayxamgul, Elyas Gulbahar, Z Y Zhou, B S Sun, Y Z Wang, M Wang
Objective: To understand the prevalence of dyslipidemia and normal blood lipids level in Uygur diabetes patients in Kashgar prefecture in southern area of Xinjiang. Methods: A total of 5 078 local residents aged ≥18 years (42.56% were men) selected through cluster random sampling in Kashgar were surveyed by means of questionnaire survey, physical examination and laboratory test, and 521 diabetes patients were screened. Results: The overall prevalence of dyslipidemia in diabetes patients was 59.50% (310/521) with adjusted rate as 49...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647503/exogenous-glucagon-like-peptide-1-reduces-body-weight-and-cholecystokinin-8-enhances-this-reduction-in-diet-induced-obese-male-rats
#7
Thaer R Mhalhal, Martha C Washington, Kayla Newman, John C Heath, Ayman I Sayegh
The sites of action regulating meal size (MS) and intermeal interval (IMI) length by glucagon like peptide-1 (7-36) (GLP-1 (7-36)) and cholecystokinin-8 (CCK-8) reside in the areas supplied by the two major branches of the abdominal aorta, celiac and cranial mesenteric arteries. We hypothesized that infusing GLP-1 near those sites reduces body weight (BW) and adding CCK-8 to this infusion enhances the reduction. Here, we measured BW in diet-induced obese (DIO) male rats maintained and tested on normal rat chow and infused with saline, GLP-1 (0...
June 21, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28647293/dynapenic-obesity-as-an-associated-factor-to-lipid-and-glucose-metabolism-disorders-and-metabolic-syndrome-in-older-adults%C3%A2-%C3%A2-findings-from-sabe-study
#8
Tiago da Silva Alexandre, Mylène Aubertin-Leheudre, Lívia Pinheiro Carvalho, Roberta de Oliveira Máximo, Ligiana Pires Corona, Tábatta Renata Pereira de Brito, Daniella Pires Nunes, Jair Licio Ferreira Santos, Yeda Aparecida de Oliveira Duarte, Maria Lúcia Lebrão
BACKGROUND & AIMS: There is little evidence showing that dynapenic obesity is associated with lipid and glucose metabolism disorders, high blood pressure, chronic disease and metabolic syndrome. Our aim was to analyze whether dynapenic abdominal obesity can be associated with lipid and glucose metabolism disorders, high blood pressure, metabolic syndrome and cardiovascular diseases in older adults living in São Paulo. METHODS: This cross-sectional study included 833 older adults who took part of the third wave of the Health, Well-being and Aging Study in 2010...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28646121/at1-receptor-blockade-attenuates-outward-aortic-remodeling-associated-with-diet-induced-obesity-in-mice
#9
Friedrich Krueger, Kai Kappert, Anna Foryst-Ludwig, Frederike Kramer, Markus Clemenz, Aleksandra Grzesiak, Manuela Sommerfeld, Jan Paul Bernhard Frese, Andreas Greiner, Ulrich Kintscher, Thomas Unger, Elena Kaschina
The renin-angiotensin-system and obesity have been implicated in vascular outward remodeling, including aneurysms, but the precise mechanisms are yet not understood. We investigated the effect of the angiotensin AT1-receptor antagonist telmisartan on aortic outward remodeling in a diet-induced obesity-model in mice. C57/Black6J mice were fed with either a low-fat diet (LFD), or a high-fat diet (HFD) for 14 weeks. One group of HFD-mice was additionally exposed to telmisartan (3mg/kg/d) for the last 4 weeks. HFD led to aortic outward remodeling, characterized by increased proteolysis, along with structural changes, such as fragmentation of elastic fibres, and decreased elastin content...
June 23, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28645552/mortality-following-augmentation-cystoplasty-a-transitional-urologist-s-viewpoint
#10
REVIEW
D A Husmann
INTRODUCTION: Three complications have been hypothesized to increase patient mortality following enterocystoplasty: spontaneous bladder perforation, bladder neoplasia, and chronic renal failure (CRF). The present study examined risk of their occurrence and discussed ways to improve the quality of care. MATERIALS AND METHODS: The present transitional clinic followed 385 patients with a history of bladder augmentation using either ileal, sigmoid, or ascending colon...
June 3, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28643300/-advantages-and-disadvantages-of-minimally-invasive-surgery-in-colorectal-cancer-surgery
#11
Minhua Zheng, Junjun Ma
Since the emergence of minimally invasive technology twenty years ago, as a surgical concept and surgical technique for colorectal cancer surgery, its obvious advantages have been recognized. Laparoscopic technology, as one of the most important technology platform, has got a lot of evidence-based support for the oncological safety and effectiveness in colorectal cancer surgery Laparoscopic technique has advantages in terms of identification of anatomic plane and autonomic nerve, protection of pelvic structure, and fine dissection of vessels...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28643234/body-mass-disorders-in-healthy-short-children-and-in-children-with-growth-hormone-deficiency
#12
Paweł Tomaszewski, Katarzyna Milde, Anna Majcher, Beata Pyrżak, Gul Tiryaki-Sonmez, Brad J Schoenfeld
The aim of the study was to determine the degree of adiposity and the incidence of body mass disorders, including abdominal obesity, in healthy short children and children with growth hormone deficiency. The study included 134 short children (height < 10th percentile) aged 7-15. In this cohort there were 63 (31 boys and 32 girls) children without diagnosed hormonal disorders and 71 patients (35 boys and 36 girls) with growth hormone deficiency. Basic somatic features were assessed and the study participants were categorized according to the percentage of body fat (%FAT), body mass index (BMI), and waist-to-height ratio (WHtR)...
June 23, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28643191/role-of-obesity-variables-in-detecting-hypertension-in-an-iranian-population
#13
Patricia Khashayar, Hamidreza Aghaei Meybodi, Mohsen Rezaei Hemami, Bagher Larijani
INTRODUCTION: As the high incidence of hypertension has been in conjunction with dramatic increase in the prevalence of obesity, many studies have suggested obesity as its underlying cause in diverse race and ethnic groups. AIM: The present study was designed to quantify the relationship between obesity variables and hypertension in Iranian population. A ROC curve analysis was also used to determine an optimal BMI cutoff for obesity with the aim of representing elevated incidence of hypertension in this population...
June 22, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28643028/polycystic-ovary-syndrome-adipose-tissue-and-metabolic-syndrome
#14
REVIEW
Alessandro P Delitala, Giampiero Capobianco, Giuseppe Delitala, Pier Luigi Cherchi, Salvatore Dessole
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD). METHODS: A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome...
June 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28641594/relationship-between-abdominal-obesity-and-alcohol-drinking-pattern-in-normal-weight-middle-aged-adults-the-korea-national-health-and-nutrition-examination-survey-2008-2013
#15
Kye-Yeung Park, Hoon-Ki Park, Hwan-Sik Hwang
OBJECTIVE: Abdominal obesity is associated with obesity-related health risks regardless of body weight. The present study aimed to determine whether alcohol drinking pattern is associated with abdominal obesity in normal-weight, middle-aged adults. DESIGN: Cross-sectional study using complex sampling design analyses. SETTING: The Korea National Health and Nutrition Examination Survey, which was conducted from 2008 to 2013. SUBJECTS: Normal-weight participants aged 40-69 years with BMI of 18·5-25·0 kg/m2 (n 11 289, 4491 men and 6798 women) were included...
June 23, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28640157/association-of-visceral-fat-area-with-the-presence-of-depressive-symptoms-in-chinese-postmenopausal-women-with-normal-glucose-tolerance
#16
Qin Xiong, Xiang Hu, Yiting Xu, Xueli Zhang, Xiaoping Pan, Yunfeng Xiao, Xiaojing Ma, Yuqian Bao, Weiping Jia
OBJECTIVE: Depression is one of the most common mental disorders, and women are more vulnerable to depression than men, particularly during stages of hormonal fluctuations. After menopause, fat accumulation shifts from the subcutaneous area to the visceral area, and the risk of metabolic disorder increases in parallel. The present study aimed to evaluate the association between abdominal fat distribution and the presence of depressive symptoms in postmenopausal women. METHODS: Visceral fat area (VFA) was detected by magnetic resonance imaging...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28638930/-different-adipose-tissue-depots-and-metabolic-syndrome-in-human
#17
Ran Wang, Xiao-Nan Li
Obesity is characterized by abnormal and excessive adipose tissue accumulated in the body. Compared with peripheral obesity (the accumulation of subcutaneous adipose tissue), abdominal obesity (the accumulation of visceral adipose tissue) is associated with increased risk of the metabolic syndrome, such as diabetes, hypertension, atherosclerosis, and dyslipidemia. Adipose tissue is a highly heterogeneous endocrine organ. Adipose tissue depots differ significantly in anatomy, cell biology, glucose and lipid metabolism as well as in endocrine regulation...
June 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28638251/what-is-the-importance-of-body-composition-in-obesity-related-depression
#18
Ulkuhan Iner Koksal, Zeynep Erturk, Ali Riza Koksal, Ekmel Burak Ozsenel, Ozlem Harmankaya Kaptanogullari
OBJECTIVE: It is known that depression is common in obese individuals. Besides the effects of obesity, pathogenic effects of increase in visceral and abdominal fat mass on depression are also being investigated. Our study aimed to show the relationship between visceral fat percentage detected with practical methods and the presence and severity of depression. MATERIALS AND METHODS: Our study included 104 obese patients and 50 healthy controls. In all individuals, the severity of depression was assessed using the Beck Depression Inventory (BDI)...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28637359/decreased-paraoxonase-2-enzymatic-activity-in-monocyte-macrophages-cells-a-comparative-in-vivo-and-in-vitro-study-for-diabetes
#19
D Lixandru, P Alexandru, A Mihai, A Roşca, C Ionescu-Tîrgovişte, L I Braşoveanu, B Manuel-Y-Keenoy
Aim To investigate peripheral blood monocytes/macrophages (Mo/Mø) paraoxonase2 (PON2) in diabetes and the factors modulating its activity. Methods 118 patients with newly diagnosed uncomplicated type 2 diabetes mellitus were compared regarding clinical, biochemical and oxidative stress parameters with 80 healthy subjects. The capacity of the peripheral blood mononuclear cells (PBMNC) to release pro-oxidants and to neutralize them was determined by measuring the respiratory burst (RB) and the intracellular antioxidant enzyme PON2...
June 21, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28637274/association-of-bariatric-surgery-with-risk-of-infectious-diseases-a-self-controlled-case-series-analysis
#20
Tadahiro Goto, Atsushi Hirayama, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
Background: Although emerging data demonstrate that obesity is a risk factor for infectious diseases, no study has investigated the relationship of bariatric surgery with the risk of infectious diseases among obese adults. Methods: We conducted a self-controlled case series analysis using data from the State Emergency Department Database and State Inpatient Database of three US states (California, Florida, and Nebraska) from 2005 through 2011. We included obese adults who underwent bariatric surgery as an instrument of weight reduction...
June 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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