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Tetsuo Nakabayashi, Ayako Hara, Hirofumi Minami
A substantial and variable placebo response can cause unreliable findings in clinical trials designed to demonstrate the efficacy of antidepressants, and the high rate of failed trials represents a major obstacle in the development of new drugs for major depressive disorder (MDD). However, the influence of demographic and symptom factors on the antidepressant effect remains to be established. The purpose of this study was to estimate the magnitude of this influence. A patient-level meta-analysis of data from double-blind, randomized, placebo-controlled trials involving the use of antidepressants for adults with MDD was performed...
January 3, 2018: Journal of Psychiatric Research
Mitesh Badiwala, Terrence Yau
PURPOSE OF REVIEW: As ventricular assist device (VAD) therapy in patients with advanced heart failure continues to grow, experience with concomitant valvular diseases present either before or after VAD implantation continues to accrue. In this review, we discuss recent data and current practice as it pertains to the subject of concomitant valvular disease in patients requiring VADs. RECENT FINDINGS: Persistent aortic valve closure has been identified as a potential contributor to aortic valve 'disuse atrophy' resulting in valve degeneration...
January 13, 2018: Current Opinion in Cardiology
André T Sugawara, Vinícius D Ramos, Fábio M Alfieri, Linamara R Battistella
PURPOSE: To investigate the levels and factors that influence the abandonment of assistive products by users of a local reference rehabilitation center. METHODS: This observational study involved users who received services and assistive products provided by our center of rehabilitation. Users were identified using the records of the center and their responses about the abandonment were collected through face-to-face interviews. RESULTS: The abandonment level of assistive products was 19...
January 15, 2018: Disability and Rehabilitation. Assistive Technology
Hardeep Singh, Janelle Unger, José Zariffa, Maureen Pakosh, Susan Jaglal, B Catharine Craven, Kristin E Musselman
Abstact Purpose: To provide an overview of the feasibility and outcomes of robotic-assisted upper extremity training for individuals with cervical spinal cord injury (SCI), and to identify gaps in current research and articulate future research directions. MATERIALS AND METHODS: A systematic search was conducted using Medline, Embase, PsycINFO, CCTR, CDSR, CINAHL and PubMed on June 7, 2017. Search terms included 3 themes: (1) robotics; (2) SCI; (3) upper extremity. Studies using robots for upper extremity rehabilitation among individuals with cervical SCI were included...
January 15, 2018: Disability and Rehabilitation. Assistive Technology
Zongyao Li, Yujin Cho, Xiang Li, Xinyu Li, Akihisa Aimi, Yoshiyuki Inaguma, Jose Antonio Alonso, Maria Teresa Fernandez-Diaz, Jiaqiang Yan, Michael C Downer, Graeme Henkelman, John B Goodenough, Jianshi Zhou
Perovskite oxides hosting ferroelectricity are particularly important materials for modern technologies. The ferroelectric transition in the well-known oxides BaTiO3 and PbTiO3 is realized by softening of a vibration mode in the cubic perovskite structure. For most perovskite oxides, octahedral-site tilting systems are developed to accommodate the bonding mismatch due to a geometric tolerance factor t = (A-O)/[√2(B-O)] < 1. In the absence of cations having lone-pair electrons, e.g. Bi3+ and Pb2+, all simple and complex A-site and B-site ordered perovskite oxides with a t < 1 show a variety of tilting systems and none of them become ferroelectric...
January 15, 2018: Journal of the American Chemical Society
Xuewei Fu, Chunhui Li, Yu Wang, Lucas Paul Kovatch, Louis Scudiero, Jin Liu, Wei-Hong Zhong
Solid polymer electrolytes play a critical role in the development of safe, flexible and all-solid-state energy storage devices. However, the low ion-conductivity has been the primary challenge impeding them from practical applications. Here, we propose a new biotechnology to fabricate novel protein-ceramic hybrid nanofillers for simultaneously boosting the ionic conductivity, mechanical properties and even adhesion properties of solid polymer electrolytes. This hybrid nanofiller is fabricated by coating ion-conductive soy-proteins onto TiO2 nanoparticles via a controlled denaturation process in appropriate solvent and conditions...
January 15, 2018: ACS Applied Materials & Interfaces
Dongyue Jiang, Seunguk Lee, Sung Woo Bae, Sung-Yong Park
With the increasing capabilities and ubiquity of smartphones and their associated digital cameras, this study presents a smartphone integrated optoelectrowetting (SiOEW) device as a simple, portable tool capable of on-chip water sample preparation and microscopic detection of the target cells in water samples, which significantly reduce the detection time and the labor cost required for water quality monitoring. A commercially available smartphone is used as a low-intensity portable light source to perform optoelectrowetting (OEW)-based microfluidic operations such as droplet transportation, merging, mixing, and immobilization on a hydrophobic detection zone...
January 15, 2018: Lab on a Chip
Toufik Sadi, Adnan Mehonic, Luca Montesi, Mark Buckwell, Anthony Kenyon, Asen Asenov
We employ an advanced three-dimensional (3D) electro-thermal simulator to explore the physics and potential of oxide-based resistive random-access memory (RRAM) cells. The physical simulation model has been developed recently, and couples a kinetic Monte Carlo study of electron and ionic transport to the self-heating phenomenon while accounting carefully for the physics of vacancy generation and recombination, and trapping mechanisms. The simulation framework successfully captures resistance switching, including the electroforming, set and reset processes, by modeling the dynamics of conductive filaments in the 3D space...
January 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Chengliang Zhang, Yanan Liu, Wei Li, Ping Gao, Dong Xiang, Xiuhua Ren, Dong Liu
A bilayered mucoadhesive buccal film containing a combination of ornidazole (OD) and dexamethasone sodium phosphate (DEX) was prepared using solvent casting to treat oral ulcers. Films were systematically evaluated in vitro to obtain the optimum formulation. The therapeutic effects of these films were investigated in the rabbit oral ulcer model and the in vivo release of OD and DEX in the human oral cavity was also evaluated. The backing layer contained ethyl cellulose and an optimal mucoadhesive layer containing both OD and DEX was produced...
January 15, 2018: Pharmaceutical Development and Technology
Marian Suarez-Escobar, Elizabeth Rendon-Velez
PURPOSE: This article aims to clarify the current state-of-the-art of robotic/mechanical devices for post-stroke thumb rehabilitation as well as the anatomical characteristics and motions of the thumb that are crucial for the development of any device that aims to support its motion. METHODS: A systematic literature search was conducted to identify robotic/mechanical devices for post-stroke thumb rehabilitation. Specific electronic databases and well-defined search terms and inclusion/exclusion criteria were used for such purpose...
January 15, 2018: Disability and Rehabilitation. Assistive Technology
Jan Filipovský, Jitka Seidlerová, Jiří Ceral, Petra Vysočanová, Jiří Špác, Miroslav Souček, Ivan Řiháček, Markéta Mateřánková, Petr König, Hana Rosolová
AIMS: Unattended automated office blood pressure (uAutoOBP) may eliminate white-coat effect. In the present study, we studied its relationships to attended office blood pressure (BP) and ambulatory BP monitoring (ABPM). MATERIAL AND METHODS: Stable treated hypertensive subjects were examined in four Czech academic hypertension centres. uAutoOBP was measured with the BP Tru device; attended BP was measured six times: three times with auscultatory method (AuscOBP) by the physician followed optionally by three oscillometric measurements (OscOBP)...
January 15, 2018: Blood Pressure
Xuan Cao, Gang Lei, Jingjing Feng, Qi Pan, Xiaodong Wen, Yan He
Creating color difference and improving the color resolution in digital imaging is crucial for better application of color analy-sis. Herein, a novel color modulation analysis strategy was developed by using a homemade tunable multiband laser illumi-nation device, in which the portions of R, G, and B components of the illumination light are discretionarily adjustable, and hence the sample color could be visually modulated continuously in the RGB color space. Through this strategy, the color appearance of single gold nanorods (AuNRs) under dark-field microscopy, was migrated from the spectrally insensitive red region to the spectrally sensitive green-yellow-red region...
January 15, 2018: Analytical Chemistry
Hyunjae Lee, Yongseok Joseph Hong, Seungmin Baik, Taeghwan Hyeon, Dae-Hyeong Kim
Blood glucose concentration is a key indicator of patients' health, particularly for symptoms associated with diabetes mellitus. Because of the large number of diabetic patients, many approaches for glucose measurement have been studied to enable continuous and accurate glucose level monitoring. Among them, electrochemical analysis is prominent because it is simple and quantitative. This technology has been incorporated into commercialized and research-level devices from simple test strips to wearable devices and implantable systems...
January 15, 2018: Advanced Healthcare Materials
Xuxu Yang, Chengrui An, Shuting Liu, Tingyu Cheng, Varitsara Bunpetch, Yixiao Liu, Shurong Dong, Shijian Li, Xiaohui Zou, Tiefeng Li, Hongwei Ouyang, Zhaohui Wu, Wei Yang
Developing soft devices for invasive procedures bears great importance for human health. The softness and large strain actuation of responsive hydrogels promise the potential to fabricate soft devices, which can attach on and assist to the function of organs. The key challenges lie in the fabrication of soft devices with robust actuating ability and biocompatibility to the attached organ. This paper presents a solution that integrates the thermoresponsive hydrogel membrane with flexible electronics and silk scaffold into a balloon-like soft device...
January 15, 2018: Advanced Healthcare Materials
Ines Verner, Torello Lotti
AGA is a common disorder. Different treatments are available to prevent hair loss and achieve hair growth with variable results. The purpose of the present study was to evaluate the efficacy and safety of a novel fractional radiofrequency (RF) device (HairLux, Innogen Technologies Ltd., Yokneam, Israel), to prevent hair loss and induce hair growth. Twenty-five patients received 10 fractional RF treatments every 2 weeks, and were followed up 2 months after the last treatment. All patients were evaluated by global photography...
January 15, 2018: Dermatologic Therapy
Zhenghui Luo, Haijun Bin, Tao Liu, Zhi-Guo Zhang, Yankang Yang, Cheng Zhong, Beibei Qiu, Guanghao Li, Wei Gao, Dongjun Xie, Kailong Wu, Yanming Sun, Feng Liu, Yongfang Li, Chuluo Yang
A novel small molecule acceptor MeIC with a methylated end-capping group is developed. Compared to unmethylated counterparts (ITCPTC), MeIC exhibits a higher lowest unoccupied molecular orbital (LUMO) level value, tighter molecular packing, better crystallites quality, and stronger absorption in the range of 520-740 nm. The MeIC-based polymer solar cells (PSCs) with J71 as donor, achieve high power conversion efficiency (PCE), up to 12.54% with a short-circuit current (JSC ) of 18.41 mA cm-2 , significantly higher than that of the device based on J71:ITCPTC (11...
January 15, 2018: Advanced Materials
Li Li, Yichuan Guo, Yuping Sun, Long Yang, Liang Qin, Shouliang Guan, Jinfen Wang, Xiaohui Qiu, Hongbian Li, Yuanyuan Shang, Ying Fang
The capability to directly build atomically thin transition metal dichalcogenide (TMD) devices by chemical synthesis offers important opportunities to achieve large-scale electronics and optoelectronics with seamless interfaces. Here, a general approach for the chemical synthesis of a variety of TMD (e.g., MoS2 , WS2 , and MoSe2 ) device arrays over large areas is reported. During chemical vapor deposition, semiconducting TMD channels and metallic TMD/carbon nanotube (CNT) hybrid electrodes are simultaneously formed on CNT-patterned substrate, and then coalesce into seamless devices...
January 15, 2018: Advanced Materials
Yejing Dai, Xingfu Wang, Wenbo Peng, Cheng Xu, Changsheng Wu, Kai Dong, Ruiyuan Liu, Zhong Lin Wang
Cadmium sulfide (CdS) has received widespread attention as the building block of optoelectronic devices due to its extraordinary optoelectronic properties, low work function, and excellent thermal and chemical stability. Here, a self-powered flexible photodetector (PD) based on p-Si/n-CdS nanowires heterostructure is fabricated. By introducing the pyro-phototronic effect derived from wurtzite structured CdS, the self-powered PD shows a broadband response range, even beyond the bandgap limitation, from UV (325 nm) to near infrared (1550 nm) under zero bias with fast response speed...
January 15, 2018: Advanced Materials
Shaowei Shi, Xubo Liu, Yanan Li, Xuefei Wu, Dong Wang, Joe Forth, Thomas P Russell
Using the interfacial jamming of cellulose nanocrystal (CNC) surfactants, a new concept, termed all-liquid molding, is introduced to produce all-liquid objects that retain the shape and details of the mold with high fidelity, yet remain all liquid and are responsive to external stimuli. This simple process, where the viscosity of the CNC dispersion can range from that of water to a crosslinked gel, opens tremendous opportunities for encapsulation, delivery systems, and unique microfluidic devices. The process described is generally applicable to any functionalized nanoparticles dispersed in one liquid and polymer ligands having complementary functionality dissolved in a second immiscible liquid...
January 15, 2018: Advanced Materials
Baosong Li, Baojuan Xi, Zhenyu Feng, Yue Lin, Jincheng Liu, Jinkui Feng, Yitai Qian, Shenglin Xiong
Sodium-ion batteries (SIBs) are considered promising next-generation energy storage devices. However, a lack of appropriate high-performance anode materials has prevented further improvements. Here, a hierarchical porous hybrid nanosheet composed of interconnected uniform TiO2 nanoparticles and nitrogen-doped graphene layer networks (TiO2 @NFG HPHNSs) that are synthesized using dual-functional C3 N4 nanosheets as both the self-sacrificing template and hybrid carbon source is reported. These HPHNSs deliver high reversible capacities of 146 mA h g-1 at 5 C for 8000 cycles, 129 mA h g-1 at 10 C for 20 000 cycles, and 116 mA h g-1 at 20 C for 10 000 cycles, as well as an ultrahigh rate capability up to 60 C with a capacity of 101 mA h g-1 ...
January 15, 2018: Advanced Materials
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