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Poly-l-lactic acid

Zhinan Fu, Kai Chen, Li Li, Fang Zhao, Yan Wang, Mingwei Wang, Yue Shen, Haixin Cui, Dianhua Liu, Xuhong Guo
Southern root-knot nematode ( Meloidogyne incognita ) is a biotrophic parasite, causing enormous loss in global crop production annually. Abamectin (Abm) is a biological and high-efficiency pesticide against Meloidogyne incognita . In this study, a powerful method, flash nanoprecipitation (FNP), was adopted to successfully produce Abm-loaded nanoparticle suspensions with high drug loading capacity (>40%) and encapsulation efficiency (>95%), where amphiphilic block copolymers (BCPs) poly(lactic-co-glycolic acid)- b -poly(ethylene glycol) (PLGA- b -PEG), poly(d,l-lactide)- b -poly(ethylene glycol) (PLA- b -PEG), or poly(caprolactone)- b -poly(ethylene glycol) (PCL- b -PEG) were used as the stabilizer to prevent the nanoparticles from aggregation...
June 20, 2018: Nanomaterials
Michele Pascali, Davide Quarato, Francesco Carinci
The ideal perioral and lip rejuvenation technique provides the longest period of efficacy, lowest complication rate, and best aesthetic results. Genetics, intrinsic aging, sun exposure and repetitive muscle twitching of the orbicularis oris produce angular, radial, and vertical lines of the perioral lines and, for this reason, the needs of patients in the treatment of this anatomical area can range from simple lip enhancement to a broader and more comprehensive treatment with simultaneous correction of perioral wrinkles...
June 18, 2018: Rejuvenation Research
Jun Harada, Takeshi Yamada, Surya Giri, Masako Hamada, Masaru K Nobu, Takashi Narihiro, Hideto Tsuji, Hiroyuki Daimon
Moorella sp. strain Hama-1 was isolated from a thermophilic anaerobic digestion reactor treating poly(l-lactic acid). The strain is a thermophilic acetogen capable of lactate oxidation under anaerobic conditions. Here, we report the draft genome sequence of strain Hama-1, comprising 3.27 Mb in 48 contigs, with a G+C content of 56.6%.
June 14, 2018: Genome Announcements
Hui-Yi Hsiao, Chin-Yu Yang, Jia-Wei Liu, Eric M Brey, Ming-Huei Cheng
Periosteal osteogenic capacity can be exploited to enhance bone formation in the fields of tissue engineering and regenerative medicine. Despite this importance, there have been no studies examining the composition, structure and osteogenic capacity of periostea from different bone sources. In this study, structure and osteogenic factor content were compared among periostea from calvarial, rib, femoral and tibial bone, in which the native bones of these four regions were harvested and subjected to histological analysis...
June 14, 2018: Tissue Engineering. Part A
Oyetunde Oyeyemi, Olajumoke Morenkeji, Funmilayo Afolayan, Kabiru Dauda, Zulaikha Busari, Jairam Meena, Amulya Panda
Mainstay chemotherapy for malaria is often faced with the problem of instability and poor bio-distribution thus resulting in impaired pharmacokinetics. Nanomedicine has been acclaimed for its success in drug delivery and improved efficacy. The aim of the study was to assess the antiplasmodial efficacy and safety of curcumin-artesunate co-entrapped nanoparticle in mice model. Curcumin (C) and artesunate (A) were loaded in poly (d,l-lactic- co -glycolic acid) (PLGA) using solvent evaporation from oil-in-water single emulsion method...
2018: Frontiers in Pharmacology
Bin Hu, Yan Li, Mohan Wang, Youming Zhu, Yong Zhou, Baiyan Sui, Yu Tan, Yujie Ning, Jie Wang, Jiacai He, Chi Yang, Duohong Zou
A considerable amount of research has focused on improving regenerative therapy strategies for repairing defects in load-bearing bones. The enhancement of tissue regeneration with microRNAs (miRNAs) is being developed because miRNAs can simultaneously regulate multiple signaling pathways in an endogenous manner. In this study, we developed a miR-210-based bone repair strategy. We identified a miRNA (miR-210-3p) that can simultaneously up-regulate the expression of multiple key osteogenic genes in vitro. This process resulted in enhanced bone formation in a subcutaneous mouse model with a miR-210-3p/poly-L-lactic acid (PLLA)/bone marrow-derived stem cell (BMSC) construct...
June 10, 2018: Acta Biomaterialia
David J Goldberg, Lawrence M Bass, Rebecca Fitzgerald, Miles H Graivier, Z Paul Lorenc
Loss of facial volume and soft-tissue support are common to types of facial aging. Restoration of a youthful appearance relies upon correction of this loss, and can be achieved in various capacities through use of biostimulatory or hyaluronic acids (HA) injectable fillers. Here, the authors discuss the versatility of calcium hydroxylapatite (CaHA) in volume replacement and the applications and facial regions for which CaHA, poly-L-lactic acid (PLLA), and HA fillers are best suited.
April 6, 2018: Aesthetic Surgery Journal
Rebecca Fitzgerald, Lawrence M Bass, David J Goldberg, Miles H Graivier, Z Paul Lorenc
Poly-L-lactic acid (PLLA) is a synthetic, biocompatible, biodegradable polymer. For soft-tissue augmentation, the size and chemical attributes of the PLLA microparticles are central to this agent's ability to promote a subclinical inflammatory response that stimulates deposition of collagen in the extracellular matrix. The resultant restoration of facial volume occurs in a controlled, predictable manner and is long lasting. The unique physiochemical and biostimulatory properties of PLLA differentiate it from other available treatments and are the foundation of the unique treatment methodology required for optimal results...
April 6, 2018: Aesthetic Surgery Journal
Yongjiu Lv, Haisheng He, Jianping Qi, Yi Lu, Weili Zhao, Xiaochun Dong, Wei Wu
Entrapment efficiency (EE) is a crucial parameter for the evaluation of nanocarriers. The accurate measurement of EE demands clear separation of nanocarriers from free drugs, which so far has not been clearly validated due to a lack of functional tools to identify nanocarriers. Herein, an environment-responsive water-quenching fluorophore was employed to label and identify model nanocarriers, polycaprolactone nanoparticles (PN), methoxy polyethylene glycol-poly(d,l-lactic acid) polymeric micelles (PM) and solid lipid nanoparticles (SLN)...
June 9, 2018: International Journal of Pharmaceutics
Yuqian Du, Chutong Tian, Menglin Wang, Di Huang, Wei Wei, Yan Liu, Lin Li, Bingjun Sun, Longfa Kou, Qiming Kan, Kexin Liu, Cong Luo, Jin Sun, Zhonggui He
Oligopeptide transporter 1 (PepT1) has been a striking prodrug-designing target. However, the underlying mechanism of PepT1 as a target to facilitate the oral absorption of nanoparticles (NPs) remains unclear. Herein, we modify Poly (lactic-co-glycolic acid) (PLGA) NPs with the conjugates of dipeptides (L-valine-valine, L-valine-phenylalanine) and polyoxyethylene (PEG Mw: 1000, 2000) stearate to facilitate oral delivery of docetaxel (DTX) to investigate the oral absorption mechanism and regulatory effects on PepT1 of the dipeptide-modified NPs...
November 2018: Drug Delivery
Qian Chen, Lu Cao, Jielin Wang, Libo Jiang, Hang Zhao, Mumingjiang Yishake, Yiqun Ma, Hao Zhou, Hong Lin, Jian Dong, Zhongyong Fan
Compared to pure poly(L-lactic acid) (PLLA), PLLA/nano-sized β-tricalcium phosphate (PLLA/nβ-TCP) composites show both superior interfacial compatibility and osteoinductive, and consequently hold great potential for bone defect repair applications. However, their dismal osteointegration limits their further development in bone regeneration, adding the need for tailored modification. In this study, a bioinspired modification approach was proposed to construct gelatinhydroxyapatite (GEL/HAP) coating onto PLLA/nβ-TCP composites by combining chemical grafting with in situ reaction methods...
May 1, 2018: Journal of Biomedical Nanotechnology
Elisabetta Pancani, Mario Menendez-Miranda, Alexandra Pastor, François Brisset, Marie-Françoise Bernet-Camard, Didier Desmaële, Ruxandra Gref
Nowadays, biodegradable polymers such as poly(lactic acid) (PLA), poly(D,L-lactic- co -glycolic acid) (PLGA) and poly( ε -caprolactone) (PCL) remain the most common biomaterials to produce drug-loaded nanoparticles (NPs). Pipemidic acid (PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL...
May 2018: Acta Pharmaceutica Sinica. B
Yong Xu, Ping Wu, Pei Feng, Wang Guo, Wenjing Yang, Cijun Shuai
The weak interfacial interaction between polymer and bioceramic leads to a low reinforcing effect, even though polymer/bioceramic scaffolds are considered potential implants. In this work, a porous poly-l-lactic acid (PLLA) scaffold containing polydopamine-modified mesoporous bioactive glass (p-MBG) was fabricated by selective laser sintering. The polydopamine was introduced as a cross-linking bridge between MBG and PLLA to improve the interfacial interaction between of them. On the one hand, the amine groups of polydopamine formed strong hydrogen bonds with the hydroxyl groups of MBG...
May 29, 2018: Colloids and Surfaces. B, Biointerfaces
Edyta Swider, Khalid Daoudi, Alexander H J Staal, Olga Koshkina, N Koen van Riessen, Eric van Dinther, I Jolanda M de Vries, Chris L de Korte, Mangala Srinivas
Photoacoustic imaging (PAI) is an emerging biomedical imaging technique that is now coming to the clinic. It has a penetration depth of a few centimeters and generates useful endogenous contrast, particularly from melanin and oxy-/deoxyhemoglobin. Indocyanine green (ICG) is a Food and Drug Administration-approved contrast agents for human applications, which can be also used in PAI. It is a small molecule dye with limited applications due to its fast clearance, rapid protein binding, and bleaching effect. Methods: Here, we entrap ICG in a poly(lactic- co -glycolic acid) nanoparticles together with a perfluorocarbon (PFC) using single emulsion method...
2018: Nanotheranostics
Luíse L Chaves, Sofia A Costa Lima, Alexandre C C Vieira, Luísa Barreiros, Marcela A Segundo, Domingos Ferreira, Bruno Sarmento, Salette Reis
The aim of this work was to assess the feasibility of drug nanosystems combination for oral therapy of multibacillary leprosy. The anti-leprotic drugs dapsone (DAP) and clofazimine (CLZ) were incorporated within polymeric nanosystems and studied per se and in combination. DAP was loaded in Eudragit L100 nanoparticles (NPs-DAP) while CLZ was loaded in (poly(lactic-co-glycolic acid) (NPs-CLZ). The nanosystems exhibited around 200 nm in size and a drug loading of 12% for each drug. In vitro cytotoxicity on intestinal Caco-2 cells revealed that after 8 h incubation, DAP alone and within NPs were not toxic up to 100 μg mL-1 , while CLZ per se was toxic, reducing cell viability to 30% at 50 μg mL-1 ...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Miroslav L Djordjevic, Uros Bumbasirevic, Borko Stojanovic, Tamara Kravic Stevovic, Tamara Martinovic, Marta Bizic, Vladimir Kojovic
Autologous tissue engineering using biodegradable scaffolds as a carrier is a well-known procedure for penile girth enhancement. We evaluated a group of previously treated patients with the aim to analyze histomorphometric changes after tissue remodeling and to estimate the benefits of repeated procedure. Between February 2012 and December 2016, a group of 21 patients, aged 22-37 (mean 28.0) years, underwent a repeated penile girth enhancement procedure with biodegradable scaffolds. Procedure included insertion of two poly-lactic-co-glycolic acid scaffolds seeded with laboratory-prepared fibroblasts from scrotal tissue specimens...
June 1, 2018: Asian Journal of Andrology
Jegarubee Bavananthasivam, Tamiru N Alkie, Jake Astill, Mohamed Faizal Abdul-Careem, Sarah K Wootton, Shahriar Behboudi, Alexander Yitbarek, Shayan Sharif
One of the economically important diseases in the poultry industry is Marek's disease (MD) which is caused by Marek's disease virus (MDV). The use of current vaccines provides protection against clinical signs of MD in chickens. However, these vaccines do not prevent the transmission of MDV to susceptible hosts, hence they may promote the development of new virulent strains of MDV. This issue persuaded us to explore alternative approaches to control MD in chickens. Induction of innate responses at the early stage of life in the chicken may help to prevent or reduce MDV infection...
May 30, 2018: Vaccine
Anwarul Hasan, Sherif Soliman, Fatima El Hajj, Yuan-Tsan Tseng, Huseyin C Yalcin, Hany Elsayed Marei
Heart valve diseases are among the leading causes of cardiac failure around the globe. Nearly 90,000 heart valve replacements occur in the USA annually. Currently, available options for heart valve replacement include bioprosthetic and mechanical valves, both of which have severe limitations. Bioprosthetic valves can last for only 10-20 years while patients with mechanical valves always require blood-thinning medications throughout the remainder of the patient's life. Tissue engineering has emerged as a promising solution for the development of a viable, biocompatible and durable heart valve; however, a human implantable tissue engineered heart valve is yet to be achieved...
May 29, 2018: Scientific Reports
C V Sijla Rosely, Baku Nagendra, Sivaprasad Vijayan Pillai, E Bhoje Gowd
This work reports on the impact of delaminated boron nitride nanosheets (BNNSs) on the crystallization behavior and crystalline structure of melt-crystallized poly-L-lactic acid (PLLA). Wide-angle X-ray diffraction and scanning electron microscopy data revealed that the addition of lower loadings of BNNSs (∼0.5 wt %) resulted in the highly dispersed PLLA nanocomposites, whereas the higher loading of BNNSs (∼ 1 wt %) leads to the agglomerated nanocomposites. It is shown that the presence of lower loadings of the BNNSs (∼0...
May 29, 2018: Journal of Physical Chemistry. B
Satoru Mitomo, Azeem Latib, Richard J Jabbour, Ozan Demir, Juan F Granada, Antonio Colombo
No abstract text is available yet for this article.
May 29, 2018: EuroIntervention
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