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Poly-l-lactic acid

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https://www.readbyqxmd.com/read/28822864/tailoring-the-wettability-and-mechanical-properties-of-electrospun-poly-l-lactic-acid-poly-glycerol-sebacate-core-shell-membranes-for-biomedical-applications
#1
Yi Yan, Vitor Sencadas, Tiantian Jin, Xufeng Huang, Jun Chen, Dongbin Wei, Zhengyi Jiang
Tissue and biomedical engineering fields are in constant mutation and in searching for innovative processing techniques capable to tailor the material properties. In this work, poly(l-lactic acid) (PLLA) and elastomeric poly(glycerol sebacate) (PGS) were dissolved in the same solvents and electrospun together, in a single needle system. A core-shell structure where the hydrophilic PGS was placed onto the surface of the hydrophobic PLLA fibre was obtained for elastomeric concentrations up to 25wt%. It was found that the PLLA:PGS blends are immiscible and the blends present the melting temperatures of the individual polymers...
August 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28819120/dual-delivery-of-fgf-2-ctgf-from-silk-fibroin-plcl-peo-coaxial-fibers-enhances-msc-proliferation-and-fibrogenesis
#2
Ruodan Xu, Huiling Zhao, Hanif Muhammad, Mingdong Dong, Flemming Besenbacher, Menglin Chen
The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolactone)-polyethylene oxide (SF/PLCL-PEO) enhanced fibrogenic lineage differentiation of MSCs. The core-shell structure was confirmed by transmission electron microscopy (TEM), fluorescence microscopy and attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814864/controlled-release-of-lovastatin-from-poly-lactic-co-glycolic-acid-nanoparticles-for-direct-pulp-capping-in-rat-teeth
#3
Hung-Pin Lin, Han-Ping Tu, Yu-Ping Hsieh, Bor-Shiunn Lee
Statin at appropriate concentrations has been shown to induce odontoblastic differentiation, dentinogenesis, and angiogenesis. However, using a carrier to control statin release might reduce toxicity and enhance its therapeutic effects. The aim of this study was to prepare poly(d,l-lactide-co-glycolide acid) (PLGA) nanoparticles that contain lovastatin for application in direct pulp capping. The PLGA-lovastatin particle size was determined using dynamic light scattering measurements and transmission electron microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28814832/combinatorial-and-sequential-delivery-of-gemcitabine-and-oseltamivir-phosphate-from-implantable-poly-d-l-lactic-co-glycolic-acid-cylinders-disables-human-pancreatic-cancer-cell-survival
#4
Stephanie Allison Logan, Amanda J Brissenden, Myron R Szewczuk, Ronald J Neufeld
Combination therapies against multiple targets are currently being developed to prevent resistance to a single chemotherapeutic agent and to extirpate pre-existing resistance in heterogeneous cancer cells in tumors due to selective pressure from the single agent. Gemcitabine (GEM), a chemotherapeutic agent, is the current standard of care for patients with pancreatic cancer. Patients with pancreatic cancer receiving GEM have a low progression-free survival. Given the poor response rate to GEM, cancer cells are known to develop rapid resistance to this drug...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28805713/polyaspartamide-based-nanoparticles-loaded-with-fluticasone-propionate-and-the-in-vitro-evaluation-towards-cigarette-smoke-effects
#5
Emanuela Fabiola Craparo, Maria Ferraro, Elisabetta Pace, Maria Luisa Bondì, Gaetano Giammona, Gennara Cavallaro
This paper describes the evaluation of polymeric nanoparticles (NPs) as a potential carrier for lung administration of fluticasone propionate (FP). The chosen polymeric material to produce NPs was a copolymer based on α,β-poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA) whose backbone was derivatised with different molecules, such as poly(lactic acid) (PLA) and polyethylenglycol (PEG). The chosen method to produce NPs from PHEA-PLA-PEG2000 was the method based on high-pressure homogenization and subsequent solvent evaporation by adding Pluronic F68 during the process and trehalose before lyophilisation...
August 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28805551/bone-targeted-cabazitaxel-nanoparticles-for-metastatic-prostate-cancer-skeletal-lesions-and-pain
#6
Andrew S Gdowski, Amalendu Ranjan, Marjana R Sarker, Jamboor K Vishwanatha
AIM: The aim of this study was to develop a novel cabazitaxel bone targeted nanoparticle (NP) system for improved drug delivery to the bone microenvironment. MATERIALS & METHODS: Nanoparticles were developed using poly(D,L-lactic-co-glycolic acid) and cabazitaxel as the core with amino-bisphosphonate surface conjugation. Optimization of nanoparticle physiochemical properties, in vitro evaluation in prostate cancer cell lines and in vivo testing in an intraosseous model of metastatic prostate cancer was performed...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28804684/bioresorbable-scaffold-as-a-dermal-substitute
#7
Lenon Cardoso, Marília Colturato Cleto, Maria Lourdes Peris Barbo, Andréa Rodrigues Esposito, Flavio Stillitano Orgaes, Eliana Aparecida de Rezende Duek
INTRODUCTION: Bioresorbable polymers are often used in medical procedures. Since they are biocompatible, this class of materials is a viable alternative for cases in which tissue regeneration is strongly compromised. Bioresorbable synthetic polymers may be used as membranes to support and guide cell growth through the process of tissue repair. OBJECTIVE: To assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28803028/novel-poly-l-lactide-graphene-oxide-films-with-improved-mechanical-flexibility-and-antibacterial-activity
#8
Zhijun Yang, Chen Sun, Liang Wang, Huixin Chen, Ji He, Yuan Chen
Poly(l-lactic acid) (PLLA) is a biocompatible polyester derived from renewable sources. It is desirable to reduce its brittleness and introduce antibacterial activity for biomedical applications by using graphene oxide (GO) as a structural and antibacterial agent. However, commonly used polymer/GO composite synthesis methods, such as physical mixing and covalent functionalization, either cause phase segregation or compromise the intrinsic properties of GO. Here, a novel approach is demonstrated to synthesize PLLA/GO films...
August 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28798869/a-novel-akermanite-poly-lactic-co-glycolic-acid-porous-composite-scaffold-fabricated-via-a-solvent-casting-particulate-leaching-method-improved-by-solvent-self-proliferating-process
#9
Yao Deng, Mengjiao Zhang, Xianchun Chen, Ximing Pu, Xiaoming Liao, Zhongbing Huang, Guangfu Yin
Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitable microenvironments mimicked the extracellular matrices for desired cellular interactions and to provide supports for the formation of new tissues. In this work, a kind of slightly soluble bioactive ceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix, a novel l-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold was fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28798866/in-vitro-and-in-vivo-degradation-behavior-of-poly-trimethylene-carbonate-co-d-l-lactic-acid-copolymer
#10
Zhengyu Ma, Yi Wu, Jing Wang, Changsheng Liu
We present P(TMC-co-DLLA) copolymer with the molar ratio of TMC: DLLA = 15: 85 was used to systematic study of in vivo and in vitro degradation behaviors. Dense homogeneous copolymer specimens were prepared by compression molding method. The in vitro and in vivo degradation were, respectively, performed at simulative body condition and implanted into rat's subcutaneous condition. Investigations were followed via physicochemical and histological analysis such as SEM, GPC, DSC, FTIR and H&E stain. The results demonstrate that copolymeric material can degrade in phosphate buffer solution (PBS) and in rat's body, and the in vivo degradation rate is faster...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28782391/in-vitro-expansion-of-cd-133-cells-derived-from-umbilical-cord-blood-in-poly-l-lactic-acid-plla-scaffold-coated-with-fibronectin-and-collagen
#11
Maryam Islami, Yousef Mortazavi, Masoud Soleimani, Samad Nadri
CONTEXT: Due to their renewal and potency, umbilical cord blood (UCB) stem cells have the ability to proliferate and serve as an attractive alternative source for bone marrow transplantation. However, insufficient number of haematopoietic stem cells (HSCs) in UCB is still a major constraint in clinical applications. OBJECTIVE: In vitro expansion of stem cells on fibronectin (Fn)-coated poly-L-lactic acid (PLLA) scaffold can be a proper way to overcome this limitation...
August 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28782240/electrophoretic-deposition-of-mgo-nanoparticles-imparts-antibacterial-properties-to-poly-l-lactic-acid-for-orthopedic-applications
#12
Daniel J Hickey, Divya Muthusamy, Thomas J Webster
Bacterial infection of implanted biomaterials is a serious problem that increases health care costs and negatively affects a considerable fraction of orthopedic procedures. In this field, magnesium oxide nanoparticles (MgO NPs) have emerged as a promising material to combat bacterial infection while maintaining or improving bone cell functions. Here, MgO NPs were electrophoretically deposited onto poly-L-lactic acid (PLLA) sheets to achieve a coating of highly exposed MgO NPs that directly influenced cell-substrate interactions at short time scales...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28773210/performance-of-poly-lactic-acid-surface-modified-films-for-food-packaging-application
#13
Valentina Siracusa, Marco Dalla Rosa, Alexey L Iordanskii
Five Poly(lactic acid) (PLA) film samples were analyzed to study the gas barrier behavior, thermal stability and mechanical performance for food packaging application. O₂, CO₂, N₂, N₂O, and C₂H₄ pure gases; Air; and Modified Atmosphere (MA, 79% N₂O/21% O₂) were used to analyze the influence of the chemical structure, storage temperature and crystalline phase on the gas barrier behavior. The kinetic of the permeation process was investigated at different temperatures, ranging from 5 °C to 40 °C...
July 25, 2017: Materials
https://www.readbyqxmd.com/read/28772552/preparation-and-investigation-of-amphiphilic-block-copolymers-fullerene-nanocomposites-as-nanocarriers-for-hydrophobic-drug
#14
Qinggang Tan, Yanyan Chu, Min Bie, Zihao Wang, Xiaoyan Xu
Biopolymer/inorganic material nanocomposites have attracted increasing interest as nanocarriers for delivering drugs owing to the combined advantages of both biopolymer and inorganic materials. Here, amphiphilic block copolymer/fullerene nanocomposites were prepared as nanocarriers for hydrophobic drug by incorporation of C60 in the core of methoxy polyethylene glycol-poly(d,l-lactic acid) (MPEG-PDLLA) micelles. The structure and morphology of MPEG-PDLLA/C60 nanocomposites were characterized using transmission electron microscopy, dynamic light scattering, high-resolution transmission electron microscopy, and thermal gravimetric analysis...
February 16, 2017: Materials
https://www.readbyqxmd.com/read/28770986/coffee-grounds-to-multifunctional-quantum-dots-extreme-nanoenhancers-of-polymer-biocomposites
#15
Huan Xu, Lan Xie, Jinlai Li, Minna Hakkarainen
Central to the design and execution of nanocomposite strategies is the invention of polymer-affinitive and multifunctional nanoreinforcements amenable to economically viable processing. Here, a microwave-assisted approach enabled gram-scale fabrication of polymer-affinitive luminescent quantum dots (QDs) from spent coffee grounds. The ultrasmall dimensions (approaching 20 nm), coupled with richness of diverse oxygen functional groups, conferred the zero-dimensional QDs with proper exfoliation and uniform dispersion in poly(l-lactic acid) (PLLA) matrix...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28769562/mithramycin-loaded-mpeg-plga-nanoparticles-exert-potent-antitumor-efficacy-against-pancreatic-carcinoma
#16
Xu-Jie Liu, Liang Li, Xiu-Jun Liu, Yi Li, Chun-Yan Zhao, Rui-Qi Wang, Yong-Su Zhen
Previous studies have shown that mithramycin A (MIT) is a promising candidate for the treatment of pancreatic carcinoma through inhibiting transcription factor Sp1. However, systemic toxicities may limit its clinical application. Here, we report a rationally designed formulation of MIT-loaded nanoparticles (MIT-NPs) with a small size and sustained release for improved passive targeting and enhanced therapeutic efficacy. Nearly spherical MIT-NPs with a mean particle size of 25.0±4.6 nm were prepared by encapsulating MIT into methoxy poly(ethylene glycol)-block-poly(d,l-lactic-co-glycolic acid) (mPEG-PLGA) nanoparticles (NPs) with drug loading of 2...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28761339/systemic-delivery-of-the-anticancer-agent-arenobufagin-using-polymeric-nanomicelles
#17
Xue Yuan, Qian Xie, Keyu Su, Zhijie Li, Dong Dong, Baojian Wu
Arenobufagin (ABG) is a major active component of toad venom, a traditional Chinese medicine used for cancer therapy. However, poor aqueous solubility limits its pharmacological studies in vivo due to administration difficulties. In this study, we aimed to develop a polymeric nanomicelle (PN) system to enhance the solubility of ABG for effective intravenous delivery. ABG-loaded PNs (ABG-PNs) were prepared with methoxy poly (ethylene glycol)-block-poly (d,l-lactic-co-glycolic acid) (mPEG-PLGA) using the solvent-diffusion technique...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28760079/preparation-of-cell-aggregates-incorporating-gelatin-hydrogel-microspheres-containing-bone-morphogenic-protein-2-with-different-degradabilities
#18
Shuhei Tajima, Yasuhiko Tabata
The objective of this study is to evaluate the survival and functions of cells in cell aggregates incorporating gelatin hydrogel microspheres (GM) containing bone morphogenic protein-2 (BMP2). Gelatin was dehydrothermally crosslinked in a water-in-oil emulsion state at 140 °C for various time periods to prepare GM with different degradabilities. BMP2 was dropped onto the GM freeze dried, followed by leaving at 25 °C to obtain GM containing BMP2 (GM-BMP2). MC3T3-E1 cells were cultured with GM-BMP2 and GM in round U-bottom wells of 96-multiwell microplates which had been coated with poly (vinyl alcohol) (PVA), to allow to form cell aggregates containing GM-BMP2 and GM, respectively...
July 31, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28753895/oestradiol-releasing-biodegradable-mesh-stimulates-collagen-production-and-angiogenesis-an-approach-to-improving-biomaterial-integration-in-pelvic-floor-repair
#19
Naşide Mangır, Christopher J Hillary, Christopher R Chapple, Sheila MacNeil
BACKGROUND: Polypropylene meshes cause severe complications in some patients. Materials that are biomechanically compatible and can better integrate into host tissues are urgently needed. OBJECTIVE: To design an oestradiol-releasing electrospun poly-l-lactic acid (PLA) mesh and evaluate its ability to stimulate new extracellular matrix and new blood vessel formation. DESIGN, SETTING, AND PARTICIPANTS: Human adipose derived mesenchymal cells (ADMSC) were isolated from fat...
June 3, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28746182/plumbagin-loaded-aptamer-targeted-poly-d-l-lactic-co-glycolic-acid-b-polyethylene-glycol-nanoparticles-for-prostate-cancer-therapy
#20
Minjie Pan, Weifeng Li, Jun Yang, Zhiqin Li, Jun Zhao, Yajun Xiao, Yifei Xing, Xiaoping Zhang, Wen Ju
Plumbagin inhibits the growth, metastasis, and invasion of prostate cancer (PCa). However, its lower bioavailability limits biopharmaceutical properties due to insolubility in water. Prostate-specific membrane antigen (PSMA) aptamer-targeted nanoparticles (NPs) significantly enhanced cytotoxicity in prostate epithelial cells. This study aimed to investigate the effects of plumbagin-loaded prostate-specific membrane antigen (PSMA) aptamer-targeted poly D,L-lactic-co-glycolic acid-b-polyethylene glycol (PLGA-PEG) nanoparticles (NPs) on prostate cancer (PCa) in vitro...
July 2017: Medicine (Baltimore)
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