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Poly-l-lactic acid

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https://www.readbyqxmd.com/read/29051810/controlled-dexamethasone-delivery-via-double-walled-microspheres-to-enhance-long-term-adipose-tissue-retention
#1
Arta Kelmendi-Doko, J Peter Rubin, Katarina Klett, Christopher Mahoney, Sheri Wang, Kacey G Marra
Current materials used for adipose tissue reconstruction have critical shortcomings such as suboptimal volume retention, donor-site morbidity, and poor biocompatibility. The aim of this study was to examine a controlled delivery system of dexamethasone to generate stable adipose tissue when mixed with disaggregated human fat in an athymic mouse model for 6 months. The hypothesis that the continued release of dexamethasone from polymeric microspheres would enhance both adipogenesis and angiogenesis more significantly when compared to the single-walled microsphere model, resulting in long-term adipose volume retention, was tested...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29037044/porous-pcl-plla-semi-ipns-as-superior-defect-specific-scaffolds-with-potential-for-cranial-bone-defect-repair
#2
Lindsay N Woodard, Kevin T Kmetz, Abigail A Roth, Vanessa M Page, Melissa A Grunlan
The treatment of irregular cranial bone defects is currently limited due to the graft resorption that can occur when an ill-fitting interface exists between an autograft and the surrounding tissue. A tissue engineering scaffold able to achieve defect-specific geometries could improve healing. This work reports a macroporous, shape memory polymer (SMP) scaffold composed of a semi-interpenetrating network (semi-IPN) of thermoplastic poly(L-lactic acid) (PLLA) within cross-linked poly(ε-caprolactone) diacrylate (PCL-DA) that is capable of conformal fit within a defect...
October 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29025656/dual-delivery-of-vegf-and-ngf-by-emulsion-electrospun-nanofibrous-scaffold-for-peripheral-nerve-regeneration
#3
Bin Xia, Yonggang Lv
Controlled delivery of multiple therapeutic agents can be considered an effective approach in nerve injury due to its multifunction. In this study, recombinant human vascular endothelial growth factor (VEGF) and recombinant human nerve growth factor (NGF) were loaded on the surface and in the core of emulsion electrospun poly (l-lactic acid) (PLLA) nanofibrous scaffold, respectively. The in vitro studies showed that VEGF and NGF had a sequential release pattern in which most of the VEFG was released in the first few days but the NGF could be continuously released for >1month...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024376/evaluation-of-collagen-foam-poly-l-lactic-acid-nanofiber-mesh-and-decellularized-matrices-for-corneal-regeneration
#4
Bahar Aslan, Selcan Guler, Atakan Tevlek, Halil Murat Aydin
Corneal tissue engineering efforts to obtain corneal tissue matrices through various types of materials for the replacement of damaged tissues. In this study, three different corneal constructs were prepared and evaluated in terms of morphological, optical, and biological characteristics. Type-I collagen was used to obtain collagen foam scaffolds through dehydrothermal crosslinking, while poly(l-lactic acid) (PLLA) was used to produce both random and aligned oriented electrospun corneal constructs. Bovine corneas were decellularized as third matrix...
October 12, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29022110/monitoring-bone-tissue-engineered-bte-constructs-based-on-the-shifting-metabolism-of-differentiating-stem-cells
#5
Aaron D Simmons, Vassilios I Sikavitsas
Ever-increasing demand for bone grafts necessitates the realization of clinical implementation of bone tissue engineered constructs. The predominant hurdle to implementation remains to be securing FDA approval, based on the lack of viable methods for the rigorous monitoring of said constructs. The study presented herein details a method for such monitoring based on the shifting metabolism of mesenchymal stem cells (MSCs) as they differentiate into osteoblasts. To that end, rat MSCs seeded on 85% porous spunbonded poly(L-lactic acid) scaffolds were cultured in flow perfusion bioreactors with baseline or osteoinductive media, and levels of key physio-metabolic markers (oxygen, glucose, osteoprotegerin, and osteocalcin) were monitored throughout culture...
October 11, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28992774/treatment-of-a-burn-animal-model-with-functionalized-tridimensional-electrospun-biomaterials
#6
Daniela Steffens, Monica Beatriz Mathor, Paula Rigon da Luz Soster, Gustavo Vergani, Dayane Piffer Luco, Patricia Pranke
Laminin-functionalized poly-d,l-lactic acid scaffolds were produced. Following this, mesenchymal stem cells and keratinocytes were seeded on biomaterials for the in vivo experiments, where the biomaterials with or without cells were implanted. The analysis is comprised of the visual aspect and mean size of the lesion plus the histology and gene expression. The results showed that the cells occupied all the structure of the scaffolds in all the groups. After nine days of in vivo experiments, the defect size did not show statistical difference among the groups, although the groups with the poly-d,l-lactic acid/Lam biomaterial had the lowest lesion size and presented the best visual aspect of the wound...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28986980/metabolic-engineering-of-bacillus-subtilis-for-production-of-d-lactic-acid
#7
Deepika Awasthi, Liang Wang Mun Su Rhee, Qingzhao Wang, Diane Chauliac, Lonnie O Ingram, K T Shanmugam
Poly lactic acid (PLA) based plastics is renewable, bio-based and biodegradable. Although present day PLA is composed of mainly L-LA, an L- and D- LA copolymer is expected to improve the quality of PLA and expand its use. To increase the number of thermotolerant microbial biocatalysts that produce D-LA, a derivative of Bacillus subtilis strain 168 that grows at 50°C was metabolically engineered. Since B. subtilis lacks a gene encoding D-lactate dehydrogenase (ldhA), five heterologous ldhA genes (B. coagulans ldhA and gldA101 and ldhA from three Lactobacillus delbrueckii) were evaluated...
October 7, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28982129/the-tyrosine-kinase-inhibitor-imatinib-mesylate-suppresses-uric-acid-crystal-induced-acute-gouty-arthritis-in-mice
#8
Laurent L Reber, Philipp Starkl, Bianca Balbino, Riccardo Sibilano, Nicolas Gaudenzio, Stephan Rogalla, Steven Sensarn, Dongmin Kang, Harini Raghu, Jeremy Sokolove, William H Robinson, Christopher H Contag, Mindy Tsai, Stephen J Galli
Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current therapies. Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of antibody-dependent arthritis and in rheumatoid arthritis in humans, but to date, the potential effects of such inhibitors on gouty arthritis has not been evaluated. Here we demonstrate that treatment with the tyrosine kinase inhibitor imatinib mesylate (imatinib) can suppress inflammation induced by injection of MSU crystals into subcutaneous air pouches or into the ankle joint of wild type mice...
2017: PloS One
https://www.readbyqxmd.com/read/28980278/do-we-need-retarded-delivery-of-bone-growth-factors-in-facial-bone-repair-an-experimental-study-in-rats
#9
N Moser, N Lohse, J Golstein, P Kauffmann, B Sven, M Epple, H Schliephake
The aim of the present study was to evaluate the effect of different dosages of retarded vs. rapid release of bone morphogenic protein 2 (BMP2) at different recipient sites. Porous composite poly(D,L-lactic acid) (PDLLA)/CaCO3 scaffolds were loaded with three different dosages of rhBMP2 (24 µg, 48 µg and 96 µg) and implanted, together with blank controls, both into non-healing defects of the mandibles and into the gluteal muscles of 24 adult male Wistar rats. After 26 weeks, bone formation and expression of bone specific markers [alkaline phosphatase (AP) and Runx2] were evaluated by histomorphometry and immunohistochemistry...
October 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28974108/l-carnitine-conjugated-nanoparticles-to-promote-permeation-across-blood-brain-barrier-and-to-target-glioma-cells-for-drug-delivery-via-the-novel-organic-cation-carnitine-transporter-octn2
#10
Longfa Kou, Yanxian Hou, Qing Yao, Weiling Guo, Gang Wang, Menglin Wang, Qiang Fu, Zhonggui He, Vadivel Ganapathy, Jin Sun
Overcoming blood-brain barrier (BBB) and targeting tumor cells are two key steps for glioma chemotherapy. By taking advantage of the specific expression of Na(+)-coupled carnitine transporter 2 (OCTN2) on both brain capillary endothelial cells and glioma cells, l-carnitine conjugated poly(lactic-co-glycolic acid) nanoparticles (LC-PLGA NPs) were prepared to enable enhanced BBB permeation and glioma-cell targeting. Conjugation of l-carnitine significantly enhanced the uptake of PLGA nanoparticles in the BBB endothelial cell line hCMEC/D3 and the glioma cell line T98G...
October 3, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28963019/an-epigenetic-bioactive-composite-scaffold-with-well-aligned-nanofibers-for-functional-tendon-tissue-engineering
#11
Can Zhang, Xianliu Wang, Erchen Zhang, Long Yang, Huihua Yuan, Wenjing Tu, Huilan Zhang, Zi Yin, Weiliang Shen, Xiao Chen, Yanzhong Zhang, Hongwei Ouyang
Poor tendon repair is often a clinical challenge due to the lack of ideal biomaterials. Electrospun aligned fibers, resembling the ultrastructure of tendon, have been previously reported to promote tenogenesis. However, the underlying mechanism is unclear and the aligned fibers alone are not capable enough to commit teno-differentiation of stem cells. Here, based on our observation of reduced expression of histone deacetylases (HDACs) in tendon stem/progenitor cells (TSPCs) cultured on aligned fibers, we proposed a strategy to enhance the tenogenesis effect of aligned fibers by using a small molecule Trichostatin A (TSA), an HDAC inhibitor...
September 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28959053/synergistic-effect-of-a-drug-loaded-electrospun-patch-and-systemic-chemotherapy-in-pancreatic-cancer-xenograft
#12
Eunsung Jun, Song Cheol Kim, Chan Mi Lee, Juyun Oh, Song Lee, In Kyong Shim
Pancreatic cancer has a high rate of local recurrence and poor prognosis even with adjuvant chemotherapy after curative resection. The aim of this study was to investigate if local drug delivery combined with low dose systemic chemotherapy can increase the therapeutic effect of chemotherapy while reducing systemic toxicities. Poly-L-lactic acid-based 5-FU releasing patch was fabricated by electrospinning, and its tumour killing effects were first confirmed in vitro. The 5-FU patch directly adhered to the tumour in subcutaneous and orthotopic murine models, and induced a significant decrease in tumour size...
September 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28948511/sn38-peg-plga-verapamil-nanoparticles-inhibit-proliferation-and-downregulate-drug-transporter-abcg2-gene-expression-in-colorectal-cancer-cells
#13
Zahra Nagheh, Shiva Irani, Reza Mirfakhraie, Rassoul Dinarvand
Nowadays, nanoparticle-based drug delivery systems are recognized to reduce the therapeutic side effects. One of the common problems in cancer treatment is cancer drug resistance, resulting from the over-expression of one energy-dependent transporter that enhances drug efflux. Irinotecan is used for metastatic colorectal cancer. The involvement of ABCG2 transporter in irinotecan resistance has been established. The current study was designed to characterize SN38-loaded pegylated (polyethylene glycol) PLGA [poly(lactic-co-glycolic acid)]-verapamil nanoparticles (NPs), and to distinguish the cytotoxic effect of SN38-PEG-PLGA-Ver NPs and the ability of SN38-PEG-PLGA-Ver NPs to inhibit drug resistance through the inhibition of ABCG2 expression...
September 25, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28946289/effect-of-nanoencapsulation-using-plga-on-antioxidant-and-antimicrobial-activities-of-guabiroba-fruit-phenolic-extract
#14
Marina C Pereira, Daniela A Oliveira, Laura E Hill, Rui Carlos Zambiazi, Caroline D Borges, Marcia Vizzotto, Susanne Mertens-Talcott, Stephen Talcott, Carmen L Gomes
Guabiroba fruit has been highlighted for its high phytochemical content, particularly of phenolic compounds. The stability, bioavailability, and bioactivity of these compounds can be enhanced by nanoencapsulation, to improve functionality. Poly(d,l-lactic-co-glycolic) acid (PLGA) nanoparticles containing phenolic extract of guabiroba (GPE) were synthesized by an adapted emulsion-evaporation method and their physico-chemical and functional properties were studied at two lactic to glycolic acid ratios (50:50 and 65:35)...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28936502/effects-of-stereo-regularity-on-the-single-chain-mechanics-of-polylactic-acid-and-its-implications-on-the-physical-properties-of-bulk-materials
#15
Bo Cheng, Lu Qian, Hu-Jun Qian, Zhong-Yuan Lu, Shuxun Cui
The material properties of polylactic acid (PLA) are largely determined by its stereo-regularity (tacticity). To find out the origin at the molecular level, the single-chain mechanics of poly-l-lactic acid (PLLA) and poly-d,l-lactide (PDLLA) were comparatively investigated by single-molecule atomic force microscopy (AFM). At a low concentration, PLLA adopted a random-coil conformation in a good solvent. At a high concentration, however, the PLLA chain can be induced into a helix, which consumed additional energy during unfolding by further stretching...
October 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28935254/design-of-gefitinib-loaded-poly-l-lactic-acid-microspheres-via-a-supercritical-anti-solvent-process-for-dry-powder-inhalation
#16
Qing Lin, Guijin Liu, Ziyi Zhao, Dongwei Wei, Jiafeng Pang, Yanbin Jiang
To develop a safer, more stable and potent formulation of gefitinib (GFB), micro-spheres of GFB encapsulated into poly (l-lactic acid) (PLLA) have been prepared by supercritical anti-solvent (SAS) technology in this study. Operating factors were optimized using a selected OA16 (4(5)) orthogonal array design, and the properties of the raw material and SAS processed samples were characterized by different methods The results show that the GFB-loaded PLLA particles prepared were spherical, having a smaller and narrower particle size compared with raw GFB...
September 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28932197/antiplasmodial-activity-and-toxicological-assessment-of-curcumin-plga-encapsulated-nanoparticles
#17
Zulaikha A Busari, Kabiru A Dauda, Olajumoke A Morenikeji, Funmilayo Afolayan, Oyetunde T Oyeyemi, Jairam Meena, Debasis Sahu, Amulya K Panda
Curcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the ancient Indian and Chinese medicine. The antiplasmodial activity of curcumin is often hampered by its fast metabolism and poor water solubility, thus its incorporation into a delivery system could circumvent this problem. This study aimed to evaluate the in vivo antiplasmodial activity and the toxicity assessment of curcumin incorporated into poly (lactic-co-glycolic) acid (PLGA) nanoparticles...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28917913/microparticle-embedded-fibroin-alginate-beads-for-prolonged-local-release-of-simvastatin-hydroxyacid-to-mesenchymal-stem-cells
#18
F Ungaro, O Catanzano, I d'Angelo, L Diaz-Gomez, A Concheiro, A Miro, C Alvarez-Lorenzo, F Quaglia
In the present work, we propose silk fibroin/alginate (SF/Alg) beads embedding simvastatin-loaded biodegradable microparticles as a versatile platform capable of tuning SVA release and in so doing osteogenic effects. In a first part of the study, microparticles of poly(lactic-co-glycolic) acid incorporating simvastatin either as lactone (SVL) or as hydroxyacid form (SVA) were prepared by spray-drying. While SVA-loaded microparticles released the drug in three days, long-term release of SVA could be obtained from SVL-loaded microparticles...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28915914/paradoxical-tunnel-enlargement-after-acl-reconstruction-with-hamstring-autografts-when-using-%C3%AE-tcp-containing-interference-screws-for-tibial-aperture-fixation-prospectively-comparative-study
#19
Joon Ho Wang, Eun Su Lee, Byung Hoon Lee
BACKGROUND: Tibial aperture fixation with a bioabsorbable interference screw is a popular fixation method in anterior cruciate ligament reconstruction (ACLR). An interference screw containing β-tricalcium phosphate (β-TCP) to improve bony integration and biocompatibility was recently introduced. This study aims to compare the clinical outcomes and radiological results of tunnel enlargement effect between the 2 bioabsorbable fixative devices of pure poly-L-lactic acid (PLLA) interference screws and β-TCP-containing screws, for tibial interference fixation in ACLR using hamstring autografts...
September 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28911889/-benefits-of-volumetric-to-facial-rejuvenation-part-2-dermal-fillers
#20
P Bui, A Pons Guiraud, C Lepage
Injectable substances known as fillers are used to palliate age-related atrophy and ptosis, and for their so-called "pseudo-lifting" action. They do not replace face and neck lift, but allow it to be postponed or, when injected after surgical lifting, make the result durable. Hyaluronic acid has a predominant and unchallenged place among fillers, well ahead of poly-L-lactic acid or calcium hydroxyapatite. Approaches and injection methods are the same for all fillers, corresponding to those for autologous fat injection, the reference substance, with a few particularities...
September 11, 2017: Annales de Chirurgie Plastique et Esthétique
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