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Poly-l-lactic acid

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https://www.readbyqxmd.com/read/29210434/nano-confinement-driven-enhanced-magnetic-relaxivity-of-spions-for-targeted-tumor-bioimaging
#1
Tuyen Duong Thanh Nguyen, Arunkumar Pitchaimani, Colin Ferrel, Ravindra Thakkar, Santosh Aryal
Superparamagnetic iron oxide nanoparticles (SPIONs) are highly biocompatible and have a versatile synthetic technique based on coprecipitation, reduction-precipitation, and hydrothermal methods, where Fe3+ and Fe2+ react in aqueous solutions; both these ions are present in our body and have clear metabolic pathways; therefore, they have attracted extensive research interest and development in the field of diagnostic imaging and therapy. However, most SPION-based clinical diagnostic contrast agents are discontinued due to severe pain, low transverse magnetic relaxivity range of 80-180 mM-1 s-1, shorter circulation half-life, and lack of disease specificity...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29208286/one-pot-biocatalytic-synthesis-of-a-biodegradable-electroactive-macromonomer-based-on-3-4-ethylenedioxytiophene-and-poly-l-lactic-acid
#2
Aruã C da Silva, Tatiana Augusto, Leandro H Andrade, Susana I Córdoba de Torresi
A novel electroactive macromonomer based on poly(l-lactic acid) (PLLA) with (3,4-ethylenedioxythiophene) (EDOT) functional end groups, was prepared by a traditional approach of organometallic polymerization with stannous octanoate [Sn(oct2)] and enzymatic polymerization using immobilized Candida antarctica Lipase B (CAL-B) and Amano lipase Pseudomonas cepacia(PS-IM), as catalysts. In the synthetic strategy, (2,3-dihydrothieno[3,4-b] dioxin-2-yl)methanol (EDOT-OH) was used to initiate the ring opening polymerization of lactide to yield PLLA with EDOT end group...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29207038/interaction-of-ipsc-derived-neural-stem-cells-on-poly-l-lactic-acid-nanofibrous-scaffolds-for-possible-use-in-neural-tissue-engineering
#3
Chengkai Lin, Chang Liu, Liangming Zhang, Zhi Huang, Peipei Zhao, Ruiqiang Chen, Mao Pang, Zhenxiang Chen, Liumin He, Chunxiao Luo, Limin Rong, Bin Liu
Tissue engineering is a rapidly growing technological area for the regeneration and reconstruction of damage to the central nervous system. By combining seed cells with appropriate biomaterial scaffolds, tissue engineering has the ability to improve nerve regeneration and functional recovery. In the present study, mouse induced pluripotent stem cells (iPSCs) were generated from mouse embryonic fibroblasts (MEFs) with the non-integrating episomal vectors pCEP4-EO2S-ET2K and pCEP4-miR-302-367 cluster, and differentiated into neural stem cells (NSCs) as transplanting cells...
November 30, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29200507/removal-of-retained-electrospinning-solvent-prolongs-drug-release-from-electrospun-plla-fibers
#4
Anthony R D'Amato, Nicholas J Schaub, Jesus M Cardenas, Andrew S Fiumara, Paul M Troiano, Andrea Fischetti, Ryan J Gilbert
A major challenge in developing drug-releasing electrospun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small molecule drugs from electrospun poly-L-lactic acid (PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication methods altered the release characteristics of a model small molecule drug, 6-aminonicotinamide (6AN), from PLLA fibers...
August 11, 2017: Polymer
https://www.readbyqxmd.com/read/29192697/mapping-piezoelectric-response-in-nanomaterials-using-a-dedicated-non-destructive-scanning-probe-technique
#5
Yonatan Calahorra, Michael Smith, Anuja Datta, Hadas Benisty, Sohini Kar-Narayan
There has been tremendous interest in piezoelectricity at the nanoscale, for example in nanowires and nanofibers where piezoelectric properties may be enhanced or controllably tuned, thus necessitating robust characterization techniques of piezoelectric response in nanomaterials. Piezo-response force microscopy (PFM) is a well-established scanning probe technique routinely used to image piezoelectric/ferroelectric domains in thin films, however, its applicability to nanoscale objects is limited due to the requirement for physical contact with an atomic force microscope (AFM) tip that may cause dislocation or damage, particularly to soft materials, during scanning...
December 1, 2017: Nanoscale
https://www.readbyqxmd.com/read/29190066/micro-pore-geometry-manipulation-by-macroscopic-deformation-based-on-shape-memory-effect-in-porous-plla-membrane-and-its-enhanced-separation-performance
#6
Jingxin Zhao, Qiucheng Yang, Tao Wang, Lian Wang, Jichun You, Yongjin Li
An effective strategy to tailor the micro-porous structures has been developed based on the shape memory effect in porous poly(L-lactic acid) membranes in which tiny crystals and amorphous matrix play the roles of shape-fixed phase and reversible-phase respectively. Our results indicate that not only PLLA membranes but micro-pores exhibit shape memory properties. The proportional deformations on two scales have been achieved by uniaxial or biaxial tension, providing a facile way to manipulate continuously the size and the orientation degree of pores on micro-scale...
November 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29187125/nitro-oleic-acid-no2oa-release-enhances-regional-angiogenesis-in-a-rat-abdominal-wall-defect-model
#7
Antonio D'Amore, Marco Fazzari, Hongbin Jiang, Samuel K Luketich, Michael E Luketich, Richard F Hoff, Daniel L Jacobs, Xinzhu Gu, Stephen F Badylak, Bruce A Freeman, William R Wagner
Ventral hernia is often addressed surgically by the placement of prosthetic materials, either synthetic or from allogeneic and xenogeneic biologic sources. Despite advances in surgical approaches and device design, a number of postsurgical limitations remain, including hernia recurrence, mesh encapsulation, and reduced vascularity of the implanted volume. The in situ controlled release of angiogenic factors from a scaffold facilitating abdominal wall repair might address some of these issues associated with sub-optimal tissue reconstruction...
November 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29186202/enhanced-cell-proliferation-and-osteogenic-differentiation-in-electrospun-plga-hydroxyapatite-nanofibre-scaffolds-incorporated-with-graphene-oxide
#8
Chuan Fu, Haotian Bai, Jiaqi Zhu, Zhihao Niu, Yu Wang, Jianan Li, Xiaoyu Yang, Yunshen Bai
One of the goals of bone tissue engineering is to mimic native ECM in architecture and function, creating scaffolds with excellent biocompatibility, osteoinductive ability and mechanical properties. The aim of this study was to fabricate nanofibrous matrices by electrospinning a blend of poly (L-lactic-co-glycolic acid) (PLGA), hydroxyapatite (HA), and grapheme oxide (GO) as a favourable platform for bone tissue engineering. The morphology, biocompatibility, mechanical properties, and biological activity of all nanofibrous matrices were compared...
2017: PloS One
https://www.readbyqxmd.com/read/29181293/increasing-the-stability-of-dna-nanostructure-templates-by-atomic-layer-deposition-of-al2o3-and-its-application-in-imprinting-lithography
#9
Hyojeong Kim, Kristin Arbutina, Anqin Xu, Haitao Liu
We present a method to increase the stability of DNA nanostructure templates through conformal coating with a nanometer-thin protective inorganic oxide layer created using atomic layer deposition (ALD). DNA nanotubes and origami triangles were coated with ca. 2 nm to ca. 20 nm of Al2O3. Nanoscale features of the DNA nanostructures were preserved after the ALD coating and the patterns are resistive to UV/O3 oxidation. The ALD-coated DNA templates were used for a direct pattern transfer to poly(L-lactic acid) films...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29173590/gene-expression-profiling-of-chicken-cecal-tonsils-and-ileum-following-oral-exposure-to-soluble-and-plga-encapsulated-cpg-odn-and-lysate-of-campylobacter-jejuni
#10
Khaled Taha-Abdelaziz, Tamiru Negash Alkie, Douglas C Hodgins, Alexander Yitbarek, Bahram Shojadoost, Shayan Sharif
Campylobacter jejuni (C. jejuni) is a leading bacterial cause of food-borne illness in humans. Contaminated chicken meat is an important source of infection for humans. Chickens are not clinically affected by colonization, and immune responses following natural infection have limited effects on bacterial load in the gut. Induction of intestinal immune responses may possibly lead to a breakdown of the commensal relationship of chickens with Campylobacter. We have recently shown that soluble and poly D, L-lactic-co-glycolic acid (PLGA)-encapsulated CpG oligodeoxynucleotide (ODN) as well as C...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29172838/in-vitro-schistosomicidal-activity-of-the-lignan-6-6-dinitrohinokinin-dnhk-loaded-into-poly-lactic-co-glycolic-acid-nanoparticles-against-schistosoma-mansoni
#11
Thaís C Lima, Rodrigo Lucarini, Priscilla P Luz, Emerson H de Faria, Liziane Marçal, Lizandra G Magalhães, Fernanda R Badoco, Viviane R Esperandim, Eduardo F Molina, Rosangela S Laurentz, Regiane G Lima, Wilson R Cunha, Jairo K Bastos, Marcio L Andrade Silva
CONTEXT: (-)-6,6'-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation. OBJECTIVE: Incorporation of DNHK in poly lactic-co-glycolic acid (PLGA) nanoparticles aiming to improve its biological activities. MATERIALS AND METHODS: Synthesis, characterization and incorporation of DNHK into glycolic acid (PLGA) nanoparticles by nanoprecipitation method. The nanoparticles were characterized by ultraviolet-visible spectroscopy, X-ray diffraction, field emission electron microscopic scanning mansoni (FESEM), and dynamic light scattering (DLS)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29171974/co-existence-effect-of-tricalcium-phosphate-and-bioactive-glass-on-biological-and-biodegradation-characteristic-of-poly-l-lactic-acid-plla-in-trinary-composite%C3%A2-scaffold-form
#12
Abbas Ghasemi, Babak Hashemi
The purpose of this study is to analyze the co-existence effect of 30 wt.% TCP-BG phases on degradation and precipitation behaviors of PLLA based composite scaffold in biological media. First, phase separation method was used to synthesize of the pure PLLA and the trinary composite scaffolds, and second they were immersed in SBF solution for 45 days. Subsequently, the degradation and precipitation characteristic were investigated by analyzing of pH value and weight changes of the immersed samples, the ability of biological products formation and the change of relative molecular weight of PLLA matrix as function of the degradation time...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29170140/a-novel-controlled-release-formulation-of-the-pin1-inhibitor-atra-to-improve-liver-cancer-therapy-by-simultaneously-blocking-multiple-cancer-pathways
#13
Dayun Yang, Wensong Luo, Jichuang Wang, Min Zheng, Xin-Hua Liao, Nan Zhang, Wenxian Lu, Long Wang, Ai-Zheng Chen, Wen-Guo Wu, Hekun Liu, Shi-Bin Wang, Xiao Zhen Zhou, Kun Ping Lu
Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide largely due to lack of effective targeted drugs to simultaneously block multiple cancer-driving pathways. The identification of all-trans retinoic acid (ATRA) as a potent Pin1 inhibitor provides a promising candidate for HCC targeted therapy because Pin1 is overexpressed in most HCC and activates numerous cancer-driving pathways. However, the efficacy of ATRA against solid tumors is limited due to its short half-life of 45min in humans...
November 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29165072/mpeg-pla-micelle-for-delivery-of-effective-parts-of-andrographis-paniculata
#14
Hailu Yao, Shiyong Song, Xiaolu Miao, Xiao Liu, Zhen Wang, Xiaoting Shao, Yu Zhang, Guang Han
Many studies have shown that Andrographis paniculata (Burm. f.) Nees has a good anti-tumor effect, but poor solubility in water and poor bioavailability hinder the modernization of it. To formulate the effective parts (mainly diterpene lactones) of Andrographis paniculata (AEP) into targeting drug delivery system, a series of poly(ethylene glycol)-poly(D.L-lactic acid)(mPEG-PLA) with different ratio of hydrophilic and hydrophobic segment were synthetized to encapsulate AEP. AEP micelles were prepared by a simple solvent-evaporation method...
November 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164777/formulation-and-characterization-of-poly-propylacrylic-acid-poly-lactic-co-glycolic-acid-blend-microparticles-for-ph-dependent-membrane-disruption-and-cytosolic-delivery
#15
Lawrence P Fernando, Jamal S Lewis, Brian C Evans, Craig L Duvall, Benjamin G Keselowsky
Poly(lactic-co-glycolic acid) (PLGA) is widely used as a vehicle for delivery of pharmaceutically relevant payloads. PLGA is readily fabricated as a nano- or microparticle (MP) matrix to load both hydrophobic and hydrophilic small molecular drugs as well as biomacromolecules such as nucleic acids and proteins. However, targeting such payloads to the cell cytosol is often limited by MP entrapment and degradation within acidic endolysosomes. Poly(propylacrylic acid) (PPAA) is a polyelectrolyte polymer with membrane disruptive capability triggered at low pH...
November 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29163995/delayed-tibial-osteomyelitis-after-anterior-cruciate-ligament-reconstruction-with-hamstrings-autograft-and-bioabsorbable-interference-screw-a-case-report-and-review-of-the-literature
#16
Kevin S Weiss, Justin M Weatherall, Jen Eick, James R Ross
Osteomyelitis following arthroscopically assisted anterior cruciate ligament (ACL) reconstruction has rarely been reported in the literature. We report a case of a 20-year-old female who had delayed tibial osteomyelitis and a pretibial cyst with culture-positive, oxacillin sensitive Staphylococcus epidermidis 15 months after an ACL reconstruction with hamstring autograft. Soft tissue fixation within the tibial tunnel was with a poly-L-D-lactic acid (PLDLA) bioabsorbable interference screw. The patient underwent surgical treatment with curettage, debridement, hardware removal, and bone grafting of the tibial tunnel followed by a course of intravenous antibiotics...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29158830/sustained-release-talazoparib-implants-for-localized-treatment-of-brca1-deficient-breast-cancer
#17
Jodi E Belz, Rajiv Kumar, Paige Baldwin, Noelle Castilla Ojo, Ana S Leal, Darlene B Royce, Di Zhang, Anne L van de Ven, Karen T Liby, Srinivas Sridhar
Talazoparib, a potent PARP inhibitor, has shown promising clinical and pre-clinical activity by inducing synthetic lethality in cancers with germline Brca1/2 mutations. Conventional oral delivery of Talazoparib is associated with significant off-target effects, therefore we sought to develop new delivery systems in the form of an implant loaded with Talazoparib for localized, slow and sustained release of the drug at the tumor site in Brca1-deficient breast cancer. Poly(lactic-co-glycolic acid) (PLGA) implants (0...
2017: Theranostics
https://www.readbyqxmd.com/read/29156133/harnessing-sphingosine-1-phosphate-signaling-and-nanotopographical-cues-to-regulate-skeletal-muscle-maturation-and-vascularization
#18
Jonathan Hung Tsui, Kajohnkiart Janebodin, Nicholas Ieronimakis, David Michael Patrick Yama, Hee Seok Yang, Rakchanok Chavanachat, Aislinn L Hays, Haeshin Lee, Morayma Reyes, Deok-Ho Kim
Despite possessing substantial regenerative capacity, skeletal muscle can suffer from loss of function due to catastrophic traumatic injury or degenerative disease. In such cases, engineered tissue grafts hold the potential to restore function and improve patient quality of life. Requirements for successful integration of engineered tissue grafts with the host musculature include cell alignment that mimics host tissue architecture and directional functionality, as well as vascularization to ensure tissue survival...
November 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29155154/poly-l-lactic-acid-nanofibers-containing-cissus-quadrangularis-induced-osteogenic-differentiation-in-vitro
#19
K Parvathi, Amit G Krishnan, A Anitha, R Jayakumar, Manitha B Nair
Cissus quadrangularis (CQ) is known as "bone setter" because of its ability to enhance fracture healing. Polymers incorporated with CQ at lower concentration have shown to enhance osteogenic differentiation of mesenchymal stem cells (MSCs) in vitro. However, for the healing of clinically relevant critical sized bone defects, large amount of CQ would be required. Based on this perception, a herbal fibrous sheet containing high weight percentage of CQ [20,40 and 60wt/wt% in poly (L-lactic acid) (PLLA)] was fabricated through electrospinning...
November 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29149727/surface-modification-of-electrospun-poly-l-lactic-acid-scaffolds-by-reactive-magnetron-sputtering
#20
E N Bolbasov, P V Maryin, K S Stankevich, A I Kozelskaya, E V Shesterikov, Yu I Khodyrevskaya, M V Nasonova, D K Shishkova, Yu A Kudryavtseva, Y G Anissimov, S I Tverdokhlebov
In this study, we modified the surface of bioresorbable electrospun poly-(l-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity...
November 12, 2017: Colloids and Surfaces. B, Biointerfaces
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