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Poly-l-lactic acid

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https://www.readbyqxmd.com/read/29675859/fabrication-of-superparamagnetic-nanofibrous-poly-l-lactic-acid-%C3%AE-fe-2-o-3-microspheres-for-cell-carriers
#1
Moyuan Qu, Wenqian Xiao, Jiarong Tian, Song Wang, Hong Li, Xue Liu, Xiaoling Yang, Bo Li, Xiaoling Liao
Nanofibrous poly(l-lactic acid) (PLLA) microspheres are extensively studied to be used as cell carriers in the field of tissue engineering because the unique structure can promote cell proliferation and migration. But as injectable scaffold materials, PLLA microspheres easily run off to the soft tissue space because of the lack of cohesive force. It will affect the treatment efficiency and even cause additional inflammatory response. In order to overcome this disadvantage, superparamagnetic γ-Fe2 O3 nanoparticles assisted with oxidative polymerization of dopamine were used for surface modification of PLLA microspheres in this study...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29674231/photoinduced-peg-deshielding-from-ros-sensitive-linkage-bridged-block-copolymer-based-nanocarriers-for-on-demand-drug-delivery
#2
Jie Li, Chunyang Sun, Wei Tao, Ziyang Cao, Haisheng Qian, Xianzhu Yang, Jun Wang
Controlling poly(ethylene glycol) (PEG) shielding/deshielding at the desired site of action exhibits great advantages for nanocarrier-based on-demand drug delivery in vivo. However, the current PEG deshielding strategies were mainly designed for anticancer drug delivery; even so, their applications are also limited by tumor heterogeneity. As a proof-of-concept, we explored a photoinduced PEG deshielding nanocarrier TK-NPCe6&PTX to circumvent the aforementioned challenge. The TK-NPCe6&PTX encapsulating chlorin e6 (Ce6) and paclitaxel (PTX) was self-assembled from an innovative thioketal (TK) linkage-bridged diblock copolymer of PEG with poly(d,l-lactic acid) (PEG-TK-PLA)...
April 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29674103/determination-of-the-cell-wall-polysaccharide-and-teichoic-acid-structures-from-lactococcus-lactis-il1403
#3
Evgeny Vinogradov, Irina Sadovskaya, Pascal Courtin, Saulius Kulakauskas, Thierry Grard, Jennifer Mahony, Douwe van Sinderen, Marie-Pierre Chapot-Chartier
In the lactic acid bacterium Lactococcus lactis, a cell wall polysaccharide (CWPS) is the bacterial receptor of the majority of infecting bacteriophages. The diversity of CWPS structures between strains explains, at least partially, the narrow host range of lactococcal phages. In the present work, we studied the polysaccharide components of the cell wall of the prototype L. lactis subsp. lactis strain IL1403. We identified a rhamnose-rich complex polysaccharide, carrying a glycerophosphate substitution, as the major component...
April 12, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29673840/versatile-effects-of-magnesium-hydroxide-nanoparticles-in-plga-scaffold-mediated-chondrogenesis
#4
Kwang-Sook Park, Byoung-Ju Kim, Eugene Lih, Wooram Park, Soo-Hong Lee, Yoon Ki Joung, Dong Keun Han
Artificial scaffolds made up of various synthetic biodegradable polymers have been reported to have many advantages including cheap manufacturing, easy scale up, high mechanical strength, convenient manipulation, and molding into an unlimited variety of shapes. However, the synthetic biodegradable polymers still have the insufficiency for cartilage regeneration owing to their acidic degradation products. To reduce acidification by degradation of synthetic polymers, we incorporated magnesium hydroxide (MH) nanoparticles into porous polymer scaffold not only to effectively neutralize the acidic hydrolysate but also to minimize the structural disturbance of scaffolds...
April 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29673188/novel-chlorhexidine-loaded-polymeric-nanoparticles-for-root-canal-treatment
#5
Gina Quiram, Francisco Montagner, Kelli L Palmer, Mihaela C Stefan, Katherine E Washington, Danieli C Rodrigues
Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs...
April 17, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29670329/preparation-and-in-vitro-in-vivo-evaluation-of-plga-microspheres-containing-norquetiapine-for-long-acting-injection
#6
Chun-Woong Park, Hyo-Jung Lee, Dong-Won Oh, Ji-Hyun Kang, Chang-Soo Han, Dong-Wook Kim
Background: Norquetiapine ( N -desalkyl quetiapine, NQ) is an active metabolite of quetiapine with stable pharmacokinetic and pharmacological properties. However, its short half-life is a drawback for clinical applications, and long-acting formulations are required. Purpose: The objectives of this study were to prepare improved entrapment efficiency NQ freebase microspheres by the solvent evaporation method with poly(d,l-lactic-co-glycolic acid) (PLGA) as a release modulator and to evaluate their physicochemical and in vitro/in vivo release properties...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29669198/surface-layer-modification-of-plga-nanoparticles-with-targeting-peptide-a-convenient-synthetic-route-for-pluronic-f127-tuftsin-conjugate
#7
Kata Horváti, Gergo Gyulai, Antal Csámpai, János Rohonczy, Eva Kiss, Szilvia Erika Bosze
Nanoparticles consist of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) are promising carriers for drug molecules to improve the treatment of tuberculosis. Surface modifiers, such as Pluronic F127, are essential for biocompatibility and for the protection against particle aggregation. This study demonstrates a successful approach to conjugate Pluronic F127 coated PLGA nanoparticles with Tuftsin, which has been reported as a macrophage-targeting peptide. Transformation of Pluronic F127 hydroxyl groups - which have limited reactivity - into aldehyde groups provide a convenient way to bind aminooxy-peptide derivatives in one step reaction...
April 18, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#8
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29664420/controlled-release-of-18-%C3%AE-glycyrrhetic-acid-by-nanodelivery-systems-increases-cytotoxicity-on-oral-carcinoma-cell-line
#9
Ilaria Cacciotti, Laura Chronopoulou, Cleofe Palocci, Adriana Amalfitano, Monica Cantiani, Massimo Cordaro, Carlo Lajolo, Cinzia Callà, Alma Boninsegna, Donatella Lucchetti, Patrizia Gallenzi, Alessandro Sgambato, Giuseppina Nocca, Alessandro Arcovito
The topical treatment for oral mucosal diseases is often based on products optimized for dermatologic applications; consequently, a lower therapeutic effect may be present.
 18-β-Glycyrrhetic Acid (GA) is extracted from Glycirrhiza glabra. The first aim of this study was to test the cytotoxicity of GA on PE/CA-PJ15 cells. The second aim was to propose and test two different delivery systems, i.e. nanoparticles and fibers, to guarantee a controlled release of GA in vitro. We used chitosan and poly(lactic-co-glycolic) acid based nanoparticles and polylactic acid fibers...
April 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29663927/encapsulation-of-5-flurouracil-into-plga-nanofibers-and-enhanced-anticancer-effect-in-combination-with-ajwa-dates-extract-phoenix-dactylifera-l
#10
Fazal Khan, Musab Aldhahri, Mohammad Asif Hussain, Kalamegam Gauthaman, Adnan Memic, Adel Abuzenadah, Taha Kumosani, Elie Barbour, Nazeeh Shuja Alothmany, Rabah Wasil Aldhaheri
Side effects connected with chemotherapeutic agents used in cancer treatment has led to alternative modalities of combinatorial therapies in an attempt to reduce the drug dosage and associated risks. In the current study we evaluated the potential use of Ajwa Dates Extract (ADE), reported to have anti-cancer effects, as an adjuvant therapy in combination with 5-flurouracil (5FU) against the human-breast-adenocarcinoma cell line (MFC-7) in vitro. The effects of ADE alone and in combination with 5-FU were evaluated in terms of cell viability and cytotoxicity...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29655516/plga-%C3%AE-tcp-composite-scaffold-incorporating-salvianolic-acid-b-promotes-bone-fusion-by-angiogenesis-and-osteogenesis-in-a-rat-spinal-fusion-model
#11
Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tricalcium phosphate (PLGA/β-TCP) were fabricated with low-temperature rapid prototyping technique, which incorporated SB at low (SB-L), middle (SB-M), high (SB-H) doses, and pure PLGA/β-TCP as blank control (Con)...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29644706/preparation-and-evaluation-of-188-re-sulfide-colloidal-nanoparticles-loaded-biodegradable-poly-l-lactic-acid-microspheres-for-radioembolization-therapy
#12
Mina Jamre, Mojtaba Shamsaei, Mostafa Erfani, Sodeh Sadjadi, Mohammad Ghannadi Maragheh
Radioembolization with radioactive microspheres has been an effective method for the treatment of liver lesions. The aim of this study was to prepare carrier-free 188 Re loaded poly (L-lactic acid) (PLLA) microspheres through 188 Re sulfide colloidal nanoparticles (188 Re-SC nanoparticles). The formation of 188 Re-SC nanoparticles was confirmed by ultraviolet-visible spectrophotometry. The labeling yield of 188 Re-SC nanoparticles was verified using the RTLC method. Effects of synthesis parameters on morphology and size of prepared 188 Re-sulfide colloidal-PLLA microspheres (188 Re-SC-PLLA microspheres) were studied by scanning electron microscopy...
April 12, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29627682/electrically-polarized-plla-nanofibers-as-neural-tissue-engineering-scaffolds-with-improved-neuritogenesis
#13
Nathalie Barroca, Ana Marote, Sandra I Vieira, Abílio Almeida, Maria H V Fernandes, Paula M Vilarinho, Odete A B da Cruz E Silva
Tissue engineering is evolving towards the production of smart platforms exhibiting stimulatory cues to guide tissue regeneration. This work explores the benefits of electrical polarization to produce more efficient neural tissue engineering platforms. Poly (l-lactic) acid (PLLA)-based scaffolds were prepared as solvent cast films and electrospun aligned nanofibers, and electrically polarized by an in-lab built corona poling device. The characterization of the platforms by thermally stimulated depolarization currents reveals a polarization of 60 × 10-10 C cm-2 that is stable on poled electrospun nanofibers for up to 6 months...
March 30, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29627542/effect-of-different-carbon-sources-on-denitrification-performance-microbial-community-structure-and-denitrification-genes
#14
Zhongshuo Xu, Xiaohu Dai, Xiaoli Chai
Solid and liquid organic substances as carbon sources for denitrification process were deeply explored. In this study, the effect of three carbon sources, referred to as poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic acid) (PHBV/PLA) polymer, glucose and CH3 COONa, on denitrification performance, microbial community and functional genes were investigated. It was found that maximum denitrification rates of 0.37, 0.46 and 0.39gN/(L·d) were achieved in PHBV/PLA, glucose and CH3 COONa supported denitrification systems, respectively...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29622085/l-inermis-loaded-nanofibrous-scaffolds-for-wound-dressing-applications
#15
Saeid Vakilian, Mohammad Norouzi, Mahsa Soufi-Zomorrod, Iman Shabani, Simzar Hosseinzadeh, Masoud Soleimani
Since ancient times, some herbal medicines have been extensively used for burn and wound treatments, showing preference to the common synthetic medications by virtue of having less side effects and faster healing rate. In this study, hybrid nanofibrous scaffolds of poly-l-lactic-acid (PLLA) and gelatin incorporated L. inermis were fabricated via electrospinning technique. Morphology and characteristics of the scaffolds were studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively...
April 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29615957/local-delivery-is-critical-for-monocyte-chemotactic-protein-1-mediated-site-specific-murine-aneurysm-healing
#16
Siham Hourani, Kartik Motwani, Daisuke Wajima, Hanain Fazal, Chad H Jones, Sylvain Doré, Koji Hosaka, Brian L Hoh
Background: Local delivery of monocyte chemotactic protein-1 (MCP-1/CCL2) via our drug-eluting coil has been shown to promote intrasaccular aneurysm healing via an inflammatory pathway. Objective: In this study, we validate the importance of local MCP-1 in murine aneurysm healing. Whether systemic, rather than local, delivery of MCP-1 can direct site-specific aneurysm healing has significant translational implications. If systemic MCP-1 is effective, then MCP-1 could be administered as a pill rather than by endovascular procedure...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29607627/safety-and-complications-of-absorbable-threads-made-of-poly-l-lactic-acid-and-poly-lactide-glycolide-experience-with-148-consecutive-patients
#17
Sukran Sarigul Guduk, Nezih Karaca
BACKGROUND: Thread lifting is a minimally invasive procedure for lifting and repositioning tissues. Few articles with absorbable sutures exist in the literature. Furthermore there is no study focusing on complications of absorbable sutures. OBJECTIVE: To describe complications of thread lifting using a totally absorbable suture composed of poly-L-lactic acid affixed with poly lactide/glycolide cones. METHODS: Data regarding complications were analyzed retrospectively for 148 patients underwent thread lifting between June 2014 and February 2017...
April 1, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29603878/bone-morphogenetic-protein-2-release-profile-modulates-bone-formation-in-phosphorylated-hydrogel
#18
Maurits G L Olthof, Diederik H R Kempen, Xifeng Liu, Mahrokh Dadsetan, Marianna A Tryfonidou, Michael J Yaszemski, Wouter J A Dhert, Lichun Lu
The optimal release profile of locally delivered BMP-2 for safe and effective clinical application is unknown. In this work, the effect of differential BMP-2 release on bone formation was investigated using a novel biomaterial oligo[(polyethylene glycol) fumarate] bis[2-(methacryloyloxy) ethyl] phosphate hydrogel (OPF-BP) containing poly(lactic-co-glycolic acid) microspheres. Three composite implants with same biomaterial chemistry and structure but different BMP-loading methods were created: BMP-2 encapsulated in microspheres (OPF-BP-Msp), BMP-2 encapsulated in microspheres and adsorbed on the phosphorylated hydrogel (OPF-BP-Cmb), and BMP-2 adsorbed on the phosphorylated hydrogel (OPF-BP-Ads)...
March 31, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29602280/air-water-interfacial-properties-of-water-spread-poly-d-l-lactic-acid-co-glycolic-acid-block-ethylene-glycol-plga-peg
#19
Hyun Chang Kim, Davis Q Arick, You-Yeon Won
Polymers at fluid-fluid interfaces are used for a number of applications that include coatings, electronics, separation, energy, cosmetics, and medicines. Here we present a fundamental study on an amphiphilic block copolymer, poly(D,L-lactic acid-co-glycolic acid-block-ethylene glycol) (PLGA-PEG), at the air-water interface. PLGA-PEG at the air-water interface prepared by using an organic spreading solvent exhibits an extremely high surface pressure without the occurrence of desorption, making it an attractive candidate for a variety of uses in the areas mentioned above...
March 30, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29600843/entanglement-based-thermoplastic-shape-memory-polymeric-particles-with-photothermal-actuation-for-biomedical-applications
#20
Qiongyu Guo, Corey J Bishop, Randall A Meyer, David R Wilson, Lauren Olasov, Daphne E Schlesinger, Patrick T Mather, James B Spicer, Jennifer H Elisseeff, Jordan J Green
Triggering shape memory functionality under clinical hyperthermia temperatures could enable the control and actuation of shape memory systems in clinical practice. For this purpose, we developed light-inducible shape memory microparticles composed of a poly (D,L-lactic acid) (PDLLA) matrix encapsulating gold nanoparticles (Au@PDLLA hybrid microparticles). This shape memory polymeric system for the first time demonstrates the capability of maintaining an anisotropic shape at body temperature with triggered shape memory effect back to a spherical shape at a narrow temperature range above body temperature with a proper shape recovery speed (37 ˚C < T < 45 ˚C)...
March 30, 2018: ACS Applied Materials & Interfaces
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