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Poly-l-lactic acid

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https://www.readbyqxmd.com/read/27931162/influence-of-the-structure-of-poly-l-lactic-acid-electrospun-fibers-on-the-bioactivity-of-endothelial-cells-proliferation-and-inflammatory-cytokines-expression
#1
Xiaoyan Liu, Xiazhi Zhang, Keke Wu, Wufeng Yang, Yanpeng Jiao, Changren Zhou
Electrospinning has been used to fabricate random and aligned poly (L-lactic acid) (PLLA) fibers with three kinds of diameter under optimal conditions. The main purpose of this paper was to investigate the influence of the diameter and orientation of fibers on the bioactivity of endothelial cells, especially on the inflammatory cytokines expression. The morphology of electrospun fibers and the cells on the fibers after 3 and 6 days culture were observed by scanning electron microscopy. Also the cell proliferation activity and cell cycle were tested and the results showed that the random fibers were more favorable for endothelial cells growth...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27930884/the-effect-of-branching-star-architecture-on-poly-d-l-lactide-pdlla-degradation-and-drug-delivery
#2
Jason Burke, Roberto Donno, Richard d'Arcy, Sarah Cartmell, Nicola Tirelli
This study focuses on the comparative evaluation of star (branched) and linear poly(L,D-lactic acid) (PDLLA) as degradable materials employed in controlled release. The polymers were prepared via ring-opening polymerization initiated by decanol (linear), pentaerythritol (4-armed star) and dipentaerythritol (6-armed star), and processed both in the form of films and nanoparticles. Independently on the length or number of their arms, star polymers degrade slower than linear polymers, possibly through a surface (vs...
December 8, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27928002/adjuvanting-an-siv-vaccine-with-tlr-ligands-encapsulated-in-nanoparticles-induces-persistent-antibody-responses-and-enhanced-protection-in-trim5%C3%AE-restrictive-macaques
#3
Sudhir Pai Kasturi, Pamela A Kozlowski, Helder I Nakaya, Matheus C Burger, Pedro Russo, Mathew Pham, Yevgeniy Kovalenkov, Eduardo L V Silveira, Colin Havenar-Daughton, Samantha L Burton, Katie M Kilgore, Mathew J Johnson, Rafiq Nabi, Traci Legere, Zarpheen Jinnah Sher, Xuemin Chen, Rama R Amara, Eric Hunter, Steven E Bosinger, Paul Spearman, Shane Crotty, Francois Villinger, Cynthia A Derdeyn, Jens Wrammert, Bali Pulendran
: Our previous work has shown that antigens adjuvanted with specific ligands for toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in poly (lactic-co-glycolic acid) (PLGA) based nanoparticles (NP), induced robust and durable immune responses in mice and macaques. We investigated the efficacy of these NP adjuvants in inducing protective immunity against simian immunodeficiency virus (SIV). Rhesus macaques (RMs) were immunized with NP containing TLR4 and TLR7/8 agonists mixed with soluble recombinant SIVmac239 derived envelope (Env) gp140 and Gag p55 (Protein), or with virus like particles (VLP) containing SIVmac239 Env and Gag...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27909870/erratum-to-evaluation-of-the-effect-of-nt-3-and-biodegradable-poly-l-lactic-acid-nanofiber-scaffolds-on-differentiation-of-rat-hair-follicle-stem-cells-into-neural-cells-in-vitro
#4
Fatemeh Moghani Ghoroghi, Leila Beygom Hejazian, Banafshe Esmaeilzade, Masumeh Dodel, Masoud Roudbari, Maliheh Nobakht
No abstract text is available yet for this article.
December 1, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27909462/difluoroboron-%C3%AE-diketonate-materials-with-long-lived-phosphorescence-enable-lifetime-based-oxygen-imaging-with-a-portable-cost-effective-camera
#5
Alexander S Mathew, Christopher A DeRosa, James N Demas, Cassandra L Fraser
Lifetime-based oxygen imaging is useful in many biological applications but instrumentation can be stationary, expensive, and complex. Herein, we present a portable, cost effective, simple alternative with high spatiotemporal resolution that uses a complementary metal oxide silicon (CMOS) camera to measure oxygen sensitive lifetimes on the millisecond scale. We demonstrate its compatibility with difluoroboron β-diketonate poly(lactic acid) (BF2bdkPLA) polymers which are nontoxic and exhibit long-lived oxygen sensitive phosphorescence...
April 21, 2016: Analytical Methods: Advancing Methods and Applications
https://www.readbyqxmd.com/read/27908574/reconstruction-of-a-post-traumatic-maxillary-ridge-using-a-radial-forearm-free-flap-and-immediate-tissue-engineering-bone-morphogenetic-protein-bone-marrow-aspirate-concentrate-and-cortical-cancellous-bone-case-report
#6
James C Melville, Ramzey Tursun, J Marshall Green, Robert E Marx
The purpose of this article is to describe reconstruction of the maxillary alveolar ridge by use of a microvascular free flap combined with an immediate tissue-engineered bone graft. This novel surgical technique involved the use of a radial forearm free flap and immediate allogeneic avascular bone graft augmented with bone morphogenetic protein and bone marrow aspirate concentrate. A poly-d,l-lactic acid mesh was used a containment unit for the bone graft. The patient was successfully treated with a viable radial forearm free flap for soft tissue and regeneration of bone with adequate height and width, which allowed the placement of 3 dental implants with excellent arch coordination...
November 9, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27906085/tissue-engineered-cardiac-patch-seeded-with-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-promoted-the-regeneration-of-host-cardiomyocytes-in-a-rat-model
#7
Tadahisa Sugiura, Narutoshi Hibino, Christopher K Breuer, Toshiharu Shinoka
BACKGROUND: Thousands of babies are born with congenital heart defects that require surgical repair involving a prosthetic implant. Lack of growth in prosthetic grafts is especially detrimental in pediatric surgery. Cell seeded biodegradable tissue engineered grafts are a novel solution to this problem. The purpose of the present study is to evaluate the feasibility of seeding human induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) onto a biodegradable cardiac patch. METHODS: The hiPS-CMs were cultured on a biodegradable patch composed of a polyglycolic acid (PGA) and a 50:50 poly (l-lactic-co-ε-caprolactone) copolymer (PLCL) for 1 week...
December 1, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27904276/late-onset-complication-of-fillers-paraffinoma-of-the-lower-eyelids-clinically-mimicking-xanthelasma
#8
Min-Woo Kim, Hyun-Sun Park, Hyun-Sun Yoon, Soyun Cho
Injectable poly-L-lactic acid (PLLA) is world-famous filler used in lipoatrophy and facial rejuvenation because of its collagen neogenesis effect which leads to gradual volume restoration. Until recently, quite a number of unwanted adverse events of PLLA have been reported. However, to the best of our knowledge, paraffinoma as a complication of PLLA has never been reported. We herein describe the first case of paraffinoma after Sculptra® injection and propose its possible mechanism.
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27900494/semi-industrial-scale-30%C3%A2-m-3-fed-batch-fermentation-for-the-production-of-d-lactate-by-escherichia-coli-strain-hbut-d15
#9
Xiangmin Fu, Yongze Wang, Jinhua Wang, Erin Garza, Ryan Manow, Shengde Zhou
D(-)-lactic acid is needed for manufacturing of stereo-complex poly-lactic acid polymer. Large scale D-lactic acid fermentation, however, has yet to be demonstrated. A genetically engineered Escherichia coli strain, HBUT-D, was adaptively evolved in a 15% calcium lactate medium for improved lactate tolerance. The resulting strain, HBUT-D15, was tested at a lab scale (7 L) by fed-batch fermentation with up to 200 g L(-1) of glucose, producing 184-191 g L(-1) of D-lactic acid, with a volumetric productivity of 4...
November 29, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27886655/gas-permeability-and-permselectivity-of-poly-l-lactic-acid-siox-film-and-its-application-in-equilibrium-modified-atmosphere-packaging-for-chilled-meat
#10
Tungalag Dong, Shuxin Song, Min Liang, Yu Wang, Xiaojing Qi, Yuqin Zhang, Xueyan Yun, Ye Jin
A layer of SiOx was deposited on the surface of poly(L-lactic acid) (PLLA) film to fabricate a PLLA/SiOx layered film, by plasma-enhanced chemical vapor deposition (PECVD) process. PLLA/SiOx film showed Young's modulus and tensile strength increased by 119.2% and 91.6%, respectively, over those of neat PLLA film. At 5 °C, the oxygen (O2 ) and carbon dioxide (CO2 ) permeability of PLLA/SiOx film decreased by 78.7% and 71.7%, respectively, and the CO2 /O2 permselectivity increased by 32.5%, compared to that of the neat PLLA film...
November 25, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27885823/novel-functionalization-strategies-of-polymeric-nanoparticles-as-carriers-for-brain-medications
#11
Corinne Portioli, Michele Bovi, Donatella Benati, Marta Donini, Massimiliano Perduca, Alessandro Romeo, Stefano Dusi, Hugo L Monaco, Marina Bentivoglio
For targeted brain delivery, nanoparticles (NPs) should bypass the blood-brain barrier (BBB). Novel functionalization strategies, based on low-density lipoprotein receptor (LDLR) binding domain, have been here tested to increase the brain targeting efficacy of poly d,l-lactic-co-glycolic acid (PLGA) NPs, biodegradable and suited for biomedical applications. Custom-made PLGA NPs were functionalized with an apolipoprotein E modified peptide (pep-apoE) responsible for LDLR binding, or with lipocalin-type prostaglandin-d-synthase (L-PGDS), highly expressed in the brain...
November 5, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27884808/biodegradable-nano-polymers-as-delivery-vehicles-for-therapeutic-small-non-coding-ribonucleic-acids
#12
REVIEW
Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Hashemi, Maryam Hejazi, Vahedeh Hosseini, Miguel de la Guardia, Mohammad Ramezani
Nowadays, small non-coding Ribo Nucleic Acids (sncRNAs) such as siRNA, miRNA and shRNA are extremely serving to gene regulation. They are involved in many biological processes and in an increasing number of studies regarding a variety of application of sncRNAs toward human health and relieving diseases ranging from metabolic disorders to those involving various organ systems as well as different types of cancer. One of the most severe limitations for applying RNA interference technology is the absence of safe and effective carriers for in vivo delivery, including localizing the molecules to a specific site of interest and sustaining the presentation of the payloads for a controlled period of time...
November 22, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27877876/enhanced-cellular-uptake-of-lactosomes-using-cell-penetrating-peptides
#13
Akiya Akahoshi, Eiji Matsuura, Eiichi Ozeki, Hayato Matsui, Kazunori Watanabe, Takashi Ohtsuki
Polymeric micelles that are composed of synthetic polymers are generally size controllable and can be easily modified for various applications. Lactosomes (A3B-type) are biodegradable polymeric micelles composed of an amphipathic polymer, including three poly(sarcosine) blocks and a poly(l-lactic acid) block. Lactosomes accumulate in tumors in vivo through the enhanced permeability and retention (EPR) effect, even on frequently administering them. However, lactosomes cannot be efficiently internalized by cells...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27877111/polymerizing-pyrrole-coated-poly-l-lactic-acid-co-%C3%AE%C2%B5-caprolactone-plcl-conductive-nanofibrous-conduit-combined-with-electric-stimulation-for-long-range-peripheral-nerve-regeneration
#14
Jialin Song, Binbin Sun, Shen Liu, Wei Chen, Yuanzheng Zhang, Chunyang Wang, Xiumei Mo, Junyi Che, Yuanming Ouyang, Weien Yuan, Cunyi Fan
Electrospinning and electric stimulation (ES) are both promising methods to support neuron adhesion and guide extension of neurons for nerve regeneration. Concurrently, all studies focus on either electrospinning for conduits material or ES in vitro study to accelerate nerve regeneration; few work on the combined use of these two strategies or ES in vivo study. Therefore, this study aimed to investigate the abilities of direct current ES through electrospinning conductive polymer composites composed of polypyrrole and Poly (l-lactic acid-co-ε-caprolactone) (PPY/PLCL) in peripheral nerve regeneration...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27875933/comparison-between-protein-repulsions-by-diblock-pla-peo-and-albumin-nanocoatings-using-owls
#15
Laurent Leclercq, Michel Vert
A previous investigation suggested that a surface bearing a rinsing-resistant depot (nanocoating) of albumin is more protein-repulsive than the same surface physically pegylated by a poly(D,L-lactic acid)-poly(ethylene oxide) diblock copolymer. To complement the study, Optical Waveguide Lightmode Spectroscopy was used to compare the mass and the thickness of protein depots from different systems, namely albumin alone at different concentrations, a mixture of albumin + fibrinogen + γ-globulin at their physiological concentrations, and sheep serum...
November 30, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27863662/surface-assembled-poly-i-c-on-pegylated-plga-microspheres-as-vaccine-adjuvant-apc-activation-and-bystander-cell-stimulation
#16
Annina M Hafner, Blaise Corthésy, Marcus Textor, Hans P Merkle
Biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres are potential vehicles to deliver antigens for vaccination. Because they lack the full capacity to activate professional antigen presenting cells (APCs), combination with an immunostimulatory adjuvant may be considered. A candidate is the synthetic TLR3 ligand polyriboinosinic acid-polyribocytidylic acid, poly(I:C), which drives cell-mediated immunity. However, poly(I:C) has also been linked to the pathogenesis of autoimmunity, as affected by widespread stimulation of non-hematopoietic bystander cells...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27860265/osmogen-mediated-one-step-technique-of-fabricating-hollow-microparticles-for-encapsulation-and-delivery-of-bioactive-molecules
#17
Sharad Kharel, Wei Li Lee, Xuan Yi Lee, Say Chye Joachim Loo
Microparticulate systems composed of biodegradable polymers, such as poly(d,l-lactic-co-glycolic acid) (PLGA), are widely used for controlled release of bioactive molecules. However, the acidic microenvironment within these microparticles, as they degrade, has been reported to perturb the configuration of most encapsulated proteins. In addition, these polymer particles are also reported to suffer from unrealistically slow and incomplete release of proteins. To address these drawbacks, hollow PLGA microparticles are fabricated through a novel one-step oil-in-water emulsion solvent evaporation technique, by capitalizing on the osmotic property of an osmogen...
November 16, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27858218/bleomycin-coated-microneedles-for-treatment-of-warts
#18
Han Sol Lee, Ha Ryeong Ryu, Joo Young Roh, Jung-Hwan Park
PURPOSE: Bleomycin-coated microneedles were devised for delivery of bleomycin into the sub-epidermal skin layer for the treatment of warts in order to provide patient convenience and reduce patient pain and fear. METHOD: Poly-lactic-acid (L-PLA) microneedles were fabricated by a molding process and then the tips were partially coated using a dip-coating method based on a microstructure well. The mechanical strength of the pre-coated polymer microneedles was observed by inserting them in porcine foot and back skin...
November 17, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27833174/thienyl-difluoroboron-%C3%AE-diketonates-in-solution-and-polylactide-media
#19
Milena Kolpaczynska, Christopher A DeRosa, William A Morris, Cassandra L Fraser
Difluoroboron β-diketonates have impressive optical properties in both solution and the solid state. In particular, both fluorescence and room-temperature phosphorescence are present when the dyes are confined to a rigid matrix, such as poly(lactic acid) (PLA). To expand current knowledge and color range capabilities of this unique type of multi-emitting chromophore, a series of thienyl-substituted BF2bdk complexes have been synthesized. The photophysical properties were investigated in methylene chloride solution and in the solid state as dye/PLA blends...
2016: Australian Journal of Chemistry
https://www.readbyqxmd.com/read/27825822/hydrophilic-poly-ethylene-glycol-capped-poly-lactic-co-glycolic-acid-nanoparticles-for-subcutaneous-delivery-of-insulin-in-diabetic-rats
#20
Saravanan S, Malathi S, Sesh P S L, Selvasubramanian S, Balasubramanian S, Pandiyan V
The aim of the present study is to evaluate the effect of insulin loaded poly(ethylene glycol) capped poly(lactic-co-glycolic)acid nanoparticles (ISPPLG NPs) by subcutaneous administration in diabetic rats. A series of biodegradable low molecular weight PLGA [90/10 (PLG2) and 80/20 (PLG4)] copolymers were synthesized by melt polycondensation and their ISPPLG NPs were synthesized by water-oil-water (W/O/W) emulsion solvent evaporation method. The PLGA copolymers and their nanoparticles were characterized. The maximum encapsulation efficiency of ISPPLG4 NPs is 66% and the diameter of the nanoparticles is about 140nm...
November 4, 2016: International Journal of Biological Macromolecules
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