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Poly-l-lactic acid

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https://www.readbyqxmd.com/read/28730531/comparing-different-tissue-engineered-repair-materials-for-the-treatment-of-pelvic-organ-prolapse-and-urinary-incontinence-which-material-is-better
#1
Xiaojuan Wang, Yisong Chen, Zhongyong Fan, Keqin Hua
INTRODUCTION AND HYPOTHESIS: Synthetic non-absorbable meshes are widely used to augment surgical repair of pelvic organ prolapse (POP) and stress urinary incontinence (SUI), but these meshes are associated with serious complications. This study compares the attachment and extracellular matrix (ECM) production of adipose-derived stem cells (ADSCs) on different biodegradable nanomaterials to develop tissue engineered repair materials. METHODS: Rat ADSCs were isolated and cultured on electrospun poly-L-lactic acid (PLA) and electrospun poly(L-lactide)-trimethylene carbonate-gycolide (PLTG) terpolymers for 1 and 2 weeks...
July 20, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28724314/developing-combination-of-artesunate-with-paclitaxel-loaded-into-poly-d-l-lactic-co-glycolic-acid-nanoparticle-for-systemic-delivery-to-exhibit-synergic-chemotherapeutic-response
#2
Bao Ngoc Tran, Hanh Thuy Nguyen, Jong Oh Kim, Chul Soon Yong, Chien Ngoc Nguyen
OBJECTIVES: Paclitaxel (PTX) has been indicated for treatment of a variety of solid tumors, while artesunate (ART) has been reported to have the potential for use in combination chemotherapy. In this study, the combination of ART and PTX was prepared in nanoparticle to induce the synergic effect and improve therapeutic efficiency in treatment of breast cancer Methods: Dual anti-cancer agents (PTX and ART) were loaded into Poly-D,L-lactic-co-glycolic acid (PLGA) nanoparticle (NP) by solvent evaporation technique from oil in water emulsion, stabilized with Tween 80...
July 20, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28722126/investigating-the-effect-of-poly-l-lactic-acid-nanoparticles-carrying-hypericin-on-the-flow-biased-diffusive-motion-of-hela-cell-organelles
#3
Rozhin Penjweini, Sarah Deville, Omid Haji Maghsoudi, Kristof Notelaers, Anitha Ethirajan, Marcel Ameloot
OBJECTIVES: In this study, we investigate in human cervical epithelial HeLa cells the intracellular dynamics and the mutual interaction with the organelles of the poly-l-lactic acid nanoparticles (PLLA NPs) carrying the naturally occurring hydrophobic photosensitizer hypericin. METHODS: Temporal and spatiotemporal image correlation spectroscopy was used for the assessment of the intracellular diffusion and directed motion of the nanocarriers by tracking the hypericin fluorescence...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28718615/development-of-nanofiber-sponges-containing-nerve-guidance-conduit-for-peripheral-nerve-regeneration-in-vivo
#4
Binbin Sun, Zi-Fei Zhou, Tong Wu, Weiming Chen, Dawei Li, Hao Zheng, Hany El-Hamshary, Salem S Al-Deyab, Xiumei Mo, Yinxian Yu
In the study of hollow nerve guidance conduit (NGC), the dispersion of regenerated axons always confused the researchers. To address this problem, filler-containing NGC was prepared, which showed better effect in the application of nerve tissue engineering. In this study, nanofiber sponges with abundant macro-pores, high porosity, and superior compressive strength were fabricated by electrospinning and freeze-drying. Poly (l-lactic acid-co-ε-caprolactone)/silk fibroin (PLCL/SF) nanofiber sponges were used as filler to prepare three-dimensional nanofiber sponges-containing (NS-containing) NGC...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28713015/folate-conjugated-and-ph-responsive-polymeric-micelles-for-target-cell-specific-anticancer-drug-delivery
#5
Jiao Guan, Zun-Qiang Zhou, Mao-Hua Chen, Hui-Yan Li, Da-Nian Tong, Jun Yang, Jing Yao, Zheng-Yun Zhang
In this study, we developed a folate (FA)-conjugated and pH-responsive active targeting micellar system for anti-cancer drug delivery. In this system, FA was attached to the terminal of the hydrophilic segment of poly(lactic acid)-poly(L-lysine) (PLA-PLL), and PLL was modified by a citric acid group. The FA receptor-mediated active targeting and electrostatic interaction between micelles and cell membrane due to a negative-to-positive charge reversal was combined in one micellar anti-cancer drug delivery system to enhance the tumour targeting and cellular internalisation of micelles...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28707999/development-of-a-membrane-of-poly-l-co-d-l-lactic-acid-co-trimethylene-carbonate-with-aloe-vera-an-alternative-biomaterial-designed-to-improve-skin-healing
#6
Daniel Komatsu, Daniel V Mistura, Adriana Motta, Juliana A Domingues, Moema A Hausen, Eliana Duek
The search for new therapies and drugs that act as topical agents to relieve pain and control the infectious processes in burns always attracted interest in clinical trials. As an alternative to synthetic drugs, the use of natural extracts is useful in the development of new strategies and formulations for improving the life quality. The aim of this study was to develop a wound dressing using Poly(L-co-D,L lactic acid-co-TMC) (PLDLA-co-TMC) containing aloe vera (AV). This natural plant extract is known for its modulatory effects under healing process...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28701488/comparative-biomechanical-behavior-and-healing-profile-of-a-novel-thinned-wall-ultrahigh-molecular-weight-amorphous-poly-l-lactic-acid-sirolimus-eluting-bioresorbable-coronary-scaffold
#7
Yanping Cheng, Pawel Gasior, Jing-Gang Xia, Kamal Ramzipoor, Chang Lee, Edward A Estrada, Daniell Dokko, Jenn C McGregor, Gerard B Conditt, Thomas McAndrew, Greg L Kaluza, Juan F Granada
BACKGROUND: Mechanical strength of bioresorbable scaffolds (BRS) is highly dependent on strut dimensions and polymer features. To date, the successful development of thin-walled BRS has been challenging. We compared the biomechanical behavior and vascular healing profile of a novel thin-walled (115 µm) sirolimus-eluting ultrahigh molecular weight amorphous poly-l-lactic acid-based BRS (APTITUDE, Amaranth Medical [AMA]) to Absorb (bioresorbable vascular scaffold [BVS]) using different experimental models...
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28698065/the-effect-of-poly-lactic-co-glycolic-acid-composition-on-the-mechanical-properties-of-electrospun-fibrous-mats
#8
X Liu, J Aho, S Baldursdottir, A Bohr, H Qu, L P Christensen, J Rantanen, M Yang
The aim of this study was to investigate the influence of polymer molecular structure on the electrospinnability and mechanical properties of electrospun fibrous mats (EFMs). Polymers with similar molecular weight but different composition ratios (lactic acid (LA) and glycolic acid (GA)) were dissolved in binary mixtures of N,N-dimethylformamide (DMF) and tetrahydrofuran (THF). The intrinsic viscosity and rheological properties of polymer solutions were investigated prior to electrospinning. The morphology and mechanical properties of the resulting EFMs were characterized by scanning electron microscope (SEM) and dynamic mechanical analysis (DMA)...
July 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28697660/neuroprotective-effects-of-a-biodegradable-poly-lactic-co-glycolic-acid-ginsenoside-rg3-nanoformulation-a-potential-nanotherapy-for-alzheimer-s-disease
#9
Ravikumar Aalinkeel, Hilliard L Kutscher, Ajay Singh, Katherine Cwiklinski, Noor Khechen, Stanley A Schwartz, Paras N Prasad, Supriya D Mahajan
It is well established that overproduction and accumulation of the β-amyloid (Aβ) peptide 1-42 (Aβ(1-42)) is a trigger of the pathological cascade in Alzheimer's disease (AD) that manifests as cognitive impairment. Ginsenoside Rg3 is an important constituent of ginseng, plays an essential role in memory and improved cognition, and is known to produce antioxidant effects via the reduction of free radicals. Therefore, ginsenoside Rg3 may be a promising candidate as a neuroprotective agent for the treatment of AD...
July 12, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28692437/codelivery-of-salinomycin-and-docetaxel-using-poly-d-l-lactic-co-glycolic-acid-poly-ethylene-glycol-nanoparticles-to-target-both-gastric-cancer-cells-and-cancer-stem-cells
#10
Lan Li, Dejun Cui, Limin Ye, Yu Li, Liyi Zhu, Lanqun Yang, Banjun Bai, Zhao Nie, Jie Gao, Yu Cao
Cancer stem cells (CSCs) in gastric cancer (GC) have been established recently as key therapeutic targets for the successful treatment of GC. Emerging evidence suggests that both CSCs and cancer cells should be eradicated to achieve optimal therapeutic efficacy. In the present study, salinomycin, which has been reported to kill CSCs, was used in combination with docetaxel, a chemotherapeutic drug that is used as first-line therapy in GC, to eradicate both GC stem cells (SCs) and cancer cells. Salinomycin and docetaxel were loaded separately into poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles of ∼140 nm with a narrow size distribution, high drug loading, and sustained drug release...
July 7, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28691484/nitric-oxide-nanosensors-for-predicting-the-development-of-osteoarthritis-in-rat-model
#11
Pan Jin, Christian Wiraja, Jinmin Zhao, Jinlu Zhang, Li Zheng, Chenjie Xu
Osteoarthritis (OA) is a chronic arthritic disease with the overproduction of inflammatory factors such as nitric oxide (NO). This study develops a NO nanosensor to predict the OA development. The nanosensor is synthesized by encapsulating NO sensing molecules (i.e. 4-amino-5-methylamino-2',7'-difluorofluorescein Diaminofluorescein-FM, DAF-FM) within biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles. In vitro, the nanosensor allows the monitoring of NO release in IL-1β-stimulated chondrocytes and the alleviative effect of NG-Monomethyl-L-arginine (L-NMMA, a NO inhibitor) and Andrographolide (an anti-inflammatory agent)...
July 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28684775/controllable-microfluidic-production-of-drug-loaded-plga-nanoparticles-using-partially-water-miscible-mixed-solvent-microdroplets-as-a-precursor
#12
Jiang Xu, Shusheng Zhang, Anais Machado, Sébastien Lecommandoux, Olivier Sandre, Frank Gu, Annie Colin
We present a versatile continuous microfluidic flow-focusing method for the production of Doxorubicin (DOX) or Tamoxifen (TAM)-loaded poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). We use a partially water-miscible solvent mixture (dimethyl sulfoxide DMSO+ dichloromethane DCM) as precursor drug/polymer solution for NPs nucleation. We extrude this partially water-miscible solution into an aqueous medium and synthesized uniform PLGA NPs with higher drug loading ability and longer sustained-release ability than conventional microfluidic or batch preparation methods...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676873/design-preparation-and-performance-of-a-novel-drug-eluting-stent-with-multiple-layer-coatings
#13
Tingzhang Hu, Song Lin, Ruolin Du, Meiling Fu, Qiong Rao, Tieying Yin, Yan Huang, Guixue Wang
Drug-eluting stents (DESs) can effectively control the harmful effects of coronary artery disease, because of their excellent ability to reduce in-stent restenosis. However, delayed re-endothelialization and late stent thrombosis have caused concern over the safety of DESs. In this study, according to time-ordered pathological responses after stent implantation, a hierarchical multiple drug-eluting stent was designed and prepared to overcome the existing DES limitations. A platelet membrane glycoprotein IIIa monoclonal antibody (SZ-21) and a vascular endothelial growth factor (VEGF121) were loaded into the inner coating of 316L stainless steel (316L SS) stents to inhibit thrombosis and promote re-endothelialization; rapamycin (RAPA) was loaded into the third layer to inhibit intima hyperplasia; a drug-free poly-l-lactic acid coating was located on the second and fourth layers and used as sustained release layers...
July 5, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28672962/enhanced-regeneration-of-large-cortical-bone-defects-with-electrospun-nanofibrous-membranes-and-low-intensity-pulsed-ultrasound
#14
Leyi Huang, Youzhi Cai, Honghua Hu, Peng Guo, Zengfeng Xin
Poly-L-lactic acid (PLLA) nanofibrous membranes are widely utilized for tissue regeneration. Low intensity pulsed ultrasound (LIPUS) has been considered as a feasible modality for bone union. The aim of the present study was to investigate the potential synergistic effect of LIPUS and PLLA electrospun nanofibrous membranes on large cortical bone defects in rabbits in vivo. The bilateral rabbit tibia defect model was constructed using 18 adult NZ rabbits and the defect sites were treated with the nanofibrous membranes combined with LIPUS or nanofibrous membranes alone...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28666885/sandwich-type-plla-nanosheets-loaded-with-bmp-2-induce-bone-regeneration-in-critical-sized-mouse-calvarial-defects
#15
Kuo-Chin Huang, Fumiko Yano, Yasutaka Murahashi, Shuta Takano, Yoshiaki Kitaura, Song Ho Chang, Kazuhito Soma, Steve W N Ueng, Sakae Tanaka, Kazuhiko Ishihara, Yosuke Okamura, Toru Moro, Taku Saito
To overcome serious clinical problems caused by large bone defects, various approaches to bone regeneration have been researched, including tissue engineering, biomaterials, stem cells and drug screening. Previously, we developed a free-standing biodegradable polymer nanosheet composed of poly(L-lactic acid) (PLLA) using a simple fabrication process consisting of spin-coating and peeling techniques. Here, we loaded recombinant human bone morphogenetic protein-2 (rhBMP-2) between two 60-nm-thick PLLA nanosheets, and investigated these sandwich-type nanosheets in bone regeneration applications...
June 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28663141/electrospun-conductive-nanofibrous-scaffolds-for-engineering-cardiac-tissue-and-3d-bioactuators
#16
Ling Wang, Yaobin Wu, Tianli Hu, Baolin Guo, Peter X Ma
Mimicking the nanofibrous structure similar to extracellular matrix and conductivity for electrical propagation of native myocardium would be highly beneficial for cardiac tissue engineering and cardiomyocytes-based bioactuators. Herein, we developed conductive nanofibrous sheets with electrical conductivity and nanofibrous structure composed of poly(L-lactic acid) (PLA) blending with polyaniline (PANI) for cardiac tissue engineering and cardiomyocytes-based 3D bioactuators. Incorporating of varying contents of PANI from 0 wt% to 3 wt% into the PLA polymer, the electrospun nanofibrous sheets showed enhanced conductivity while maintaining the same fiber diameter...
June 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28661032/cotransporting-ion-is-a-trigger-for-cellular-endocytosis-of-transporter-targeting-nanoparticles-a-case-study-of-high-efficiency-slc22a5-octn2-mediated-carnitine-conjugated-nanoparticles-for-oral-delivery-of-therapeutic-drugs
#17
Longfa Kou, Qing Yao, Mengchi Sun, Chunnuan Wu, Jia Wang, Qiuhua Luo, Gang Wang, Yuqian Du, Qiang Fu, Jian Wang, Zhonggui He, Vadivel Ganapathy, Jin Sun
OCTN2 (SLC22A5) is a Na(+) -coupled absorption transporter for l-carnitine in small intestine. This study tests the potential of this transporter for oral delivery of therapeutic drugs encapsulated in l-carnitine-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticles (LC-PLGA NPs) and discloses the molecular mechanism for cellular endocytosis of transporter-targeting nanoparticles. Conjugation of l-carnitine to a surface of PLGA-NPs enhances the cellular uptake and intestinal absorption of encapsulated drug...
June 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28659922/a-poly-lactic-co-glycolic-acid-nanovaccine-based-on-chimeric-peptides-from-different-leishmania-infantum-proteins-induces-dendritic-cells-maturation-and-promotes-peptide-specific-ifn%C3%AE-producing-cd8-t-cells-essential-for-the-protection-against-experimental-visceral
#18
Evita Athanasiou, Maria Agallou, Spyros Tastsoglou, Olga Kammona, Artemis Hatzigeorgiou, Costas Kiparissides, Evdokia Karagouni
Visceral leishmaniasis, caused by Leishmania (L.) donovani and L. infantum protozoan parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates. An effective vaccine against the disease must rely on the generation of a strong and long-lasting T cell immunity, mediated by CD4(+) TH1 and CD8(+) T cells. Multi-epitope peptide-based vaccine development is manifesting as the new era of vaccination strategies against Leishmania infection. In this study, we designed chimeric peptides containing HLA-restricted epitopes from three immunogenic L...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28658997/evaluation-of-the-potential-of-kartogenin-encapsulated-poly-l-lactic-acid-co-caprolactone-collagen-nanofibers-for-tracheal-cartilage-regeneration
#19
Haiyue Yin, Juan Wang, Ziqi Gu, Wenhao Feng, Manchen Gao, Yu Wu, Hao Zheng, Xiaomin He, Xiumei Mo
Tracheal stenosis is one of major challenging issues in clinical medicine because of the poor intrinsic ability of tracheal cartilage for repair. Tissue engineering provides an alternative method for the treatment of tracheal defects by generating replacement tracheal structures. In this study, we fabricated coaxial electrospun fibers using poly(L-lactic acid-co-caprolactone) and collagen solution as shell fluid and kartogenin solution as core fluid. Scanning electron microscope and transmission electron microscope images demonstrated that nanofibers had uniform and smooth structure...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28653337/hardystonite-coated-poly-l-lactide-nanofibrous-scaffold-and-efficient-osteogenic-differentiation-of-adipose-derived-mesenchymal-stem-cells
#20
Banafsheh Tavangar, Shaghayegh Arasteh, Haleh Edalatkhah, Ali Salimi, Ali Doostmohammadi, Ehsan Seyedjafari
In this study, a ceramic-coated nanofibrous scaffold has been fabricated to biomimic the microstructure of natural extracellular matrix and the stiffening inorganic compartment of bone. Poly-l-lactic acid (PLLA) nanofibers were electrospun and exposed to oxygen plasma to induce hydrophilicity and promote ceramic adsorption. Hardystonite (HS), which possesses superior osteoinduction potential over hydroxyapatite, was coated on plasma-treated PLLA nanofibers by drenching the nanofibers in HS suspension. Pure and composite PLLA-based scaffolds were characterized in terms of physical and biological properties...
June 27, 2017: Artificial Organs
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